NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|2217302432|ref|XP_047288936|]
View 

thrombospondin-1 isoform X1 [Homo sapiens]

Protein Classification

TSPN and TSP_C domain-containing protein( domain architecture ID 10641979)

protein containing domains TSPN, VWC, TSP1, and TSP_C

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
TSP_C pfam05735
Thrombospondin C-terminal region; This region is found at the C-terminus of thrombospondin and ...
 972-1169 2.97e-117

Thrombospondin C-terminal region; This region is found at the C-terminus of thrombospondin and related proteins.


:

Pssm-ID: 461725  Cd Length: 198  Bit Score: 361.18  E-value: 2.97e-117
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217302432  972 QNDPNWVVRHQGKELVQTVNCDPGLAVGYDEFNAVDFSGTFFINTERDDDYAGFVFGYQSSSRFYVVMWKQVTQSYWDTN 1051
Cdd:pfam05735    1 QIDPIWVIRNQGREIQQTDNSDPGLAIGFDRFGSVDFSGTFFVNTDDDDDYIGFVFGYQSNSKFYVVMWKQVNQSYWPFK 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217302432 1052 PTRAQGYSGLSVKVVNSTTGPGEHLRNALWHTGNTPGQVRTLWHDPRHIGWKDFTAYRWRLSHRPKTGFIRVVMYEGKKI 1131
Cdd:pfam05735   81 PFRATGLKGIQLKVVKSTTGPGENLRNALWHTGDTTNQVRLLWHDPTWRGWKDRTAYRWHLQHRPSIGLIRVRVYEGITL 160

                          170       180       190
                   ....*....|....*....|....*....|....*...
gi 2217302432 1132 MADSGPIYDKTYAGGRLGLFVFSQEMVFFSDLKYECRD 1169
Cdd:pfam05735  161 LADSGNVYDTTIRGGRLGVFCFSQENVIWSDLKYKCLD 198
TSPN smart00210
Thrombospondin N-terminal -like domains; Heparin-binding and cell adhesion domain of ...
 26-221 1.15e-49

Thrombospondin N-terminal -like domains; Heparin-binding and cell adhesion domain of thrombospondin


:

Pssm-ID: 214560  Cd Length: 184  Bit Score: 174.08  E-value: 1.15e-49
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217302432    26 GDNSVFDIFELTGAARKGSGRRlvkgpdPSSPAFRIEDanliPPVPDDKFQDLVDaVRAEKGFLLLASLRQMKKTRGTLL 105
Cdd:smart00210    3 DLLQVFDLPSLSFAIRQVVGPE------PGSPAYRLGD----PALVPQPTRDLFP-SGLPEDFSLLTTFRQTPKSRGVLF 71

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217302432   106 ALERKDhSGQVFSVVSNGKAGTLDLS-LTVQGKQHVVSVEEALLATGQWKSITLFVQEDRAQLYIDCEKMENAELDVPIQ 184
Cdd:smart00210   72 AIYDAQ-NVRQFGLEVDGRANTLLLRyQGVDGKQHTVSFRNLPLADGQWHKLALSVSGSSATLYVDCNEIDSRPLDRPGQ 150

                           170       180       190
                    ....*....|....*....|....*....|....*..
gi 2217302432   185 svfTRDLASIARLRIAKGGVNDNFQGVLQNVRFVFGT 221
Cdd:smart00210  151 ---PPIDTDGIEVRGAQAADRKPFQGDLQQLKIVCDP 184
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 438-490 3.43e-18

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


:

Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 79.17  E-value: 3.43e-18
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|...
gi 2217302432   438 WSHWSPWSSCSVTCGDGVITRIRLCNSPSPQMNGKPCEGEARETKACKKDACP 490
Cdd:smart00209    1 WSEWSEWSPCSVTCGGGVQTRTRSCCSPPPQNGGGPCTGEDVETRACNEQPCP 53
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 495-547 4.78e-18

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


:

Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 78.78  E-value: 4.78e-18
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|...
gi 2217302432   495 WGPWSPWDICSVTCGGGVQKRSRLCNNPTPQFGGKDCVGDVTENQICNKQDCP 547
Cdd:smart00209    1 WSEWSEWSPCSVTCGGGVQTRTRSCCSPPPQNGGGPCTGEDVETRACNEQPCP 53
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 318-372 2.23e-17

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


:

Pssm-ID: 278520  Cd Length: 57  Bit Score: 77.08  E-value: 2.23e-17
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 2217302432  318 CYHNGVQYRNNEEWTVDSCTECHCQNSVTICKKVSCPIMPCSNAT--VPDGECCPRC 372
Cdd:pfam00093    1 CVQNGVVYENGETWKPDLCTICTCDDGKVLCDKIICPPLDCPNPRleIPPGECCPVC 57
TSP_1 pfam00090
Thrombospondin type 1 domain;
383-428 1.05e-12

Thrombospondin type 1 domain;


:

Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 63.59  E-value: 1.05e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 2217302432  383 SPWSEWTSCSTSCGNGIQQRGRSCDSL---NNRCEGSSVQTRTCHIQEC 428
Cdd:pfam00090    1 SPWSPWSPCSVTCGKGIQVRQRTCKSPfpgGEPCTGDDIETQACKMDKC 49
TSP_3 pfam02412
Thrombospondin type 3 repeat; The thrombospondin repeat is a short aspartate rich repeat which ...
 846-882 2.33e-09

Thrombospondin type 3 repeat; The thrombospondin repeat is a short aspartate rich repeat which binds to calcium ions. The repeat was initially identified in thrombospondin proteins that contained 7 of these repeats. The repeat lacks defined secondary structure.


:

Pssm-ID: 367074  Cd Length: 36  Bit Score: 53.52  E-value: 2.33e-09
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 2217302432  846 DSDSDRIGDTCDNnqDIDEDGHQNNLDNCPYVPNANQ 882
Cdd:pfam02412    2 DSDSDGVGDACDN--DFDNDGVPDLLDNCPNNANIDQ 36
TSP_3 pfam02412
Thrombospondin type 3 repeat; The thrombospondin repeat is a short aspartate rich repeat which ...
 786-821 1.36e-08

Thrombospondin type 3 repeat; The thrombospondin repeat is a short aspartate rich repeat which binds to calcium ions. The repeat was initially identified in thrombospondin proteins that contained 7 of these repeats. The repeat lacks defined secondary structure.


:

Pssm-ID: 367074  Cd Length: 36  Bit Score: 51.60  E-value: 1.36e-08
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 2217302432  786 ADTDNNGEGDACAADIDGDGILNERDNCQYVYNVDQ 821
Cdd:pfam02412    1 TDSDSDGVGDACDNDFDNDGVPDLLDNCPNNANIDQ 36
TSP_3 pfam02412
Thrombospondin type 3 repeat; The thrombospondin repeat is a short aspartate rich repeat which ...
 919-952 2.19e-07

Thrombospondin type 3 repeat; The thrombospondin repeat is a short aspartate rich repeat which binds to calcium ions. The repeat was initially identified in thrombospondin proteins that contained 7 of these repeats. The repeat lacks defined secondary structure.


:

Pssm-ID: 367074  Cd Length: 36  Bit Score: 48.13  E-value: 2.19e-07
                           10        20        30
                   ....*....|....*....|....*....|....
gi 2217302432  919 KDSDGDGRGDACKDDFDHDSVPDIDDICPENVDI 952
Cdd:pfam02412    1 TDSDSDGVGDACDNDFDNDGVPDLLDNCPNNANI 34
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 650-689 1.21e-06

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


:

Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 46.05  E-value: 1.21e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 2217302432  650 CTDGTHDCNKNAKCNYlghySDPMYRCECKPGYAGNGIIC 689
Cdd:pfam12947    1 CSDNNGGCHPNATCTN----TGGSFTCTCNDGYTGDGVTC 36
 
Name Accession Description Interval E-value
TSP_C pfam05735
Thrombospondin C-terminal region; This region is found at the C-terminus of thrombospondin and ...
 972-1169 2.97e-117

Thrombospondin C-terminal region; This region is found at the C-terminus of thrombospondin and related proteins.


Pssm-ID: 461725  Cd Length: 198  Bit Score: 361.18  E-value: 2.97e-117
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217302432  972 QNDPNWVVRHQGKELVQTVNCDPGLAVGYDEFNAVDFSGTFFINTERDDDYAGFVFGYQSSSRFYVVMWKQVTQSYWDTN 1051
Cdd:pfam05735    1 QIDPIWVIRNQGREIQQTDNSDPGLAIGFDRFGSVDFSGTFFVNTDDDDDYIGFVFGYQSNSKFYVVMWKQVNQSYWPFK 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217302432 1052 PTRAQGYSGLSVKVVNSTTGPGEHLRNALWHTGNTPGQVRTLWHDPRHIGWKDFTAYRWRLSHRPKTGFIRVVMYEGKKI 1131
Cdd:pfam05735   81 PFRATGLKGIQLKVVKSTTGPGENLRNALWHTGDTTNQVRLLWHDPTWRGWKDRTAYRWHLQHRPSIGLIRVRVYEGITL 160

                          170       180       190
                   ....*....|....*....|....*....|....*...
gi 2217302432 1132 MADSGPIYDKTYAGGRLGLFVFSQEMVFFSDLKYECRD 1169
Cdd:pfam05735  161 LADSGNVYDTTIRGGRLGVFCFSQENVIWSDLKYKCLD 198
TSPN smart00210
Thrombospondin N-terminal -like domains; Heparin-binding and cell adhesion domain of ...
 26-221 1.15e-49

Thrombospondin N-terminal -like domains; Heparin-binding and cell adhesion domain of thrombospondin


Pssm-ID: 214560  Cd Length: 184  Bit Score: 174.08  E-value: 1.15e-49
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217302432    26 GDNSVFDIFELTGAARKGSGRRlvkgpdPSSPAFRIEDanliPPVPDDKFQDLVDaVRAEKGFLLLASLRQMKKTRGTLL 105
Cdd:smart00210    3 DLLQVFDLPSLSFAIRQVVGPE------PGSPAYRLGD----PALVPQPTRDLFP-SGLPEDFSLLTTFRQTPKSRGVLF 71

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217302432   106 ALERKDhSGQVFSVVSNGKAGTLDLS-LTVQGKQHVVSVEEALLATGQWKSITLFVQEDRAQLYIDCEKMENAELDVPIQ 184
Cdd:smart00210   72 AIYDAQ-NVRQFGLEVDGRANTLLLRyQGVDGKQHTVSFRNLPLADGQWHKLALSVSGSSATLYVDCNEIDSRPLDRPGQ 150

                           170       180       190
                    ....*....|....*....|....*....|....*..
gi 2217302432   185 svfTRDLASIARLRIAKGGVNDNFQGVLQNVRFVFGT 221
Cdd:smart00210  151 ---PPIDTDGIEVRGAQAADRKPFQGDLQQLKIVCDP 184
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 438-490 3.43e-18

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 79.17  E-value: 3.43e-18
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|...
gi 2217302432   438 WSHWSPWSSCSVTCGDGVITRIRLCNSPSPQMNGKPCEGEARETKACKKDACP 490
Cdd:smart00209    1 WSEWSEWSPCSVTCGGGVQTRTRSCCSPPPQNGGGPCTGEDVETRACNEQPCP 53
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 495-547 4.78e-18

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 78.78  E-value: 4.78e-18
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|...
gi 2217302432   495 WGPWSPWDICSVTCGGGVQKRSRLCNNPTPQFGGKDCVGDVTENQICNKQDCP 547
Cdd:smart00209    1 WSEWSEWSPCSVTCGGGVQTRTRSCCSPPPQNGGGPCTGEDVETRACNEQPCP 53
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 318-372 2.23e-17

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 77.08  E-value: 2.23e-17
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 2217302432  318 CYHNGVQYRNNEEWTVDSCTECHCQNSVTICKKVSCPIMPCSNAT--VPDGECCPRC 372
Cdd:pfam00093    1 CVQNGVVYENGETWKPDLCTICTCDDGKVLCDKIICPPLDCPNPRleIPPGECCPVC 57
TSP_1 pfam00090
Thrombospondin type 1 domain;
439-489 1.90e-16

Thrombospondin type 1 domain;


Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 73.99  E-value: 1.90e-16
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 2217302432  439 SHWSPWSSCSVTCGDGVITRIRLCNSPSPQmnGKPCEGEARETKACKKDAC 489
Cdd:pfam00090    1 SPWSPWSPCSVTCGKGIQVRQRTCKSPFPG--GEPCTGDDIETQACKMDKC 49
TSP_1 pfam00090
Thrombospondin type 1 domain;
496-546 1.02e-14

Thrombospondin type 1 domain;


Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 69.37  E-value: 1.02e-14
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 2217302432  496 GPWSPWDICSVTCGGGVQKRSRLCNNPTPqfGGKDCVGDVTENQICNKQDC 546
Cdd:pfam00090    1 SPWSPWSPCSVTCGKGIQVRQRTCKSPFP--GGEPCTGDDIETQACKMDKC 49
VWC smart00214
von Willebrand factor (vWF) type C domain;
318-372 1.73e-14

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214564  Cd Length: 59  Bit Score: 69.08  E-value: 1.73e-14
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*....
gi 2217302432   318 CYHNGVQYRNNEEWTVDSCTECHCQNSVTI-CKKVSCPIMP-CSNAT--VPDGECCPRC 372
Cdd:smart00214    1 CVHNGRVYNDGETWKPDPCQICTCLDGTTVlCDPVECPPPPdCPNPErvKPPGECCPRC 59
TSP_1 pfam00090
Thrombospondin type 1 domain;
383-428 1.05e-12

Thrombospondin type 1 domain;


Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 63.59  E-value: 1.05e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 2217302432  383 SPWSEWTSCSTSCGNGIQQRGRSCDSL---NNRCEGSSVQTRTCHIQEC 428
Cdd:pfam00090    1 SPWSPWSPCSVTCGKGIQVRQRTCKSPfpgGEPCTGDDIETQACKMDKC 49
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 382-429 3.24e-12

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 62.22  E-value: 3.24e-12
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|...
gi 2217302432   382 WSPWSEWTSCSTSCGNGIQQRGRSCDSLNNR-----CEGSSVQTRTCHIQECD 429
Cdd:smart00209    1 WSEWSEWSPCSVTCGGGVQTRTRSCCSPPPQngggpCTGEDVETRACNEQPCP 53
TSP_3 pfam02412
Thrombospondin type 3 repeat; The thrombospondin repeat is a short aspartate rich repeat which ...
 846-882 2.33e-09

Thrombospondin type 3 repeat; The thrombospondin repeat is a short aspartate rich repeat which binds to calcium ions. The repeat was initially identified in thrombospondin proteins that contained 7 of these repeats. The repeat lacks defined secondary structure.


Pssm-ID: 367074  Cd Length: 36  Bit Score: 53.52  E-value: 2.33e-09
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 2217302432  846 DSDSDRIGDTCDNnqDIDEDGHQNNLDNCPYVPNANQ 882
Cdd:pfam02412    2 DSDSDGVGDACDN--DFDNDGVPDLLDNCPNNANIDQ 36
TSP_3 pfam02412
Thrombospondin type 3 repeat; The thrombospondin repeat is a short aspartate rich repeat which ...
 786-821 1.36e-08

Thrombospondin type 3 repeat; The thrombospondin repeat is a short aspartate rich repeat which binds to calcium ions. The repeat was initially identified in thrombospondin proteins that contained 7 of these repeats. The repeat lacks defined secondary structure.


Pssm-ID: 367074  Cd Length: 36  Bit Score: 51.60  E-value: 1.36e-08
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 2217302432  786 ADTDNNGEGDACAADIDGDGILNERDNCQYVYNVDQ 821
Cdd:pfam02412    1 TDSDSDGVGDACDNDFDNDGVPDLLDNCPNNANIDQ 36
TSP_3 pfam02412
Thrombospondin type 3 repeat; The thrombospondin repeat is a short aspartate rich repeat which ...
 919-952 2.19e-07

Thrombospondin type 3 repeat; The thrombospondin repeat is a short aspartate rich repeat which binds to calcium ions. The repeat was initially identified in thrombospondin proteins that contained 7 of these repeats. The repeat lacks defined secondary structure.


Pssm-ID: 367074  Cd Length: 36  Bit Score: 48.13  E-value: 2.19e-07
                           10        20        30
                   ....*....|....*....|....*....|....
gi 2217302432  919 KDSDGDGRGDACKDDFDHDSVPDIDDICPENVDI 952
Cdd:pfam02412    1 TDSDSDGVGDACDNDFDNDGVPDLLDNCPNNANI 34
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 650-689 1.21e-06

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 46.05  E-value: 1.21e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 2217302432  650 CTDGTHDCNKNAKCNYlghySDPMYRCECKPGYAGNGIIC 689
Cdd:pfam12947    1 CSDNNGGCHPNATCTN----TGGSFTCTCNDGYTGDGVTC 36
PTZ00441 PTZ00441
sporozoite surface protein 2 (SSP2); Provisional
 496-517 2.60e-03

sporozoite surface protein 2 (SSP2); Provisional


Pssm-ID: 240420 [Multi-domain]  Cd Length: 576  Bit Score: 41.87  E-value: 2.60e-03
                           10        20
                   ....*....|....*....|..
gi 2217302432  496 GPWSPWDICSVTCGGGVQKRSR 517
Cdd:PTZ00441   241 GPWDEWTPCSVTCGKGTHSRSR 262
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 124-217 5.79e-03

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 38.17  E-value: 5.79e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217302432  124 KAGTLDLSLTVQGKQHVVSVEEALLATGQWKSITLFVQEDRAQLYID-CEKMENAELDVPIQSVFTRDL---ASIARLRI 199
Cdd:pfam02210   26 VNGRLVLRYDLGSGPESLLSSGKNLNDGQWHSVRVERNGNTLTLSVDgQTVVSSLPPGESLLLNLNGPLylgGLPPLLLL 105

                           90
                   ....*....|....*...
gi 2217302432  200 AKGGVNDNFQGVLQNVRF 217
Cdd:pfam02210  106 PALPVRAGFVGCIRDVRV 123
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 124-217 9.33e-03

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 38.17  E-value: 9.33e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217302432  124 KAGTLDLSLTVQGKQHVVSVEEaLLATGQWKSITLFVQEDRAQLYIDCEKMENAELDVPIQSVFTRDL----ASIARLRI 199
Cdd:cd00110     54 EDGRLVLRYDLGSGSLVLSSKT-PLNDGQWHSVSVERNGRSVTLSVDGERVVESGSPGGSALLNLDGPlylgGLPEDLKS 132

                           90
                   ....*....|....*...
gi 2217302432  200 AKGGVNDNFQGVLQNVRF 217
Cdd:cd00110    133 PGLPVSPGFVGCIRDLKV 150
 
Name Accession Description Interval E-value
TSP_C pfam05735
Thrombospondin C-terminal region; This region is found at the C-terminus of thrombospondin and ...
 972-1169 2.97e-117

Thrombospondin C-terminal region; This region is found at the C-terminus of thrombospondin and related proteins.


Pssm-ID: 461725  Cd Length: 198  Bit Score: 361.18  E-value: 2.97e-117
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217302432  972 QNDPNWVVRHQGKELVQTVNCDPGLAVGYDEFNAVDFSGTFFINTERDDDYAGFVFGYQSSSRFYVVMWKQVTQSYWDTN 1051
Cdd:pfam05735    1 QIDPIWVIRNQGREIQQTDNSDPGLAIGFDRFGSVDFSGTFFVNTDDDDDYIGFVFGYQSNSKFYVVMWKQVNQSYWPFK 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217302432 1052 PTRAQGYSGLSVKVVNSTTGPGEHLRNALWHTGNTPGQVRTLWHDPRHIGWKDFTAYRWRLSHRPKTGFIRVVMYEGKKI 1131
Cdd:pfam05735   81 PFRATGLKGIQLKVVKSTTGPGENLRNALWHTGDTTNQVRLLWHDPTWRGWKDRTAYRWHLQHRPSIGLIRVRVYEGITL 160

                          170       180       190
                   ....*....|....*....|....*....|....*...
gi 2217302432 1132 MADSGPIYDKTYAGGRLGLFVFSQEMVFFSDLKYECRD 1169
Cdd:pfam05735  161 LADSGNVYDTTIRGGRLGVFCFSQENVIWSDLKYKCLD 198
TSPN smart00210
Thrombospondin N-terminal -like domains; Heparin-binding and cell adhesion domain of ...
 26-221 1.15e-49

Thrombospondin N-terminal -like domains; Heparin-binding and cell adhesion domain of thrombospondin


Pssm-ID: 214560  Cd Length: 184  Bit Score: 174.08  E-value: 1.15e-49
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217302432    26 GDNSVFDIFELTGAARKGSGRRlvkgpdPSSPAFRIEDanliPPVPDDKFQDLVDaVRAEKGFLLLASLRQMKKTRGTLL 105
Cdd:smart00210    3 DLLQVFDLPSLSFAIRQVVGPE------PGSPAYRLGD----PALVPQPTRDLFP-SGLPEDFSLLTTFRQTPKSRGVLF 71

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217302432   106 ALERKDhSGQVFSVVSNGKAGTLDLS-LTVQGKQHVVSVEEALLATGQWKSITLFVQEDRAQLYIDCEKMENAELDVPIQ 184
Cdd:smart00210   72 AIYDAQ-NVRQFGLEVDGRANTLLLRyQGVDGKQHTVSFRNLPLADGQWHKLALSVSGSSATLYVDCNEIDSRPLDRPGQ 150

                           170       180       190
                    ....*....|....*....|....*....|....*..
gi 2217302432   185 svfTRDLASIARLRIAKGGVNDNFQGVLQNVRFVFGT 221
Cdd:smart00210  151 ---PPIDTDGIEVRGAQAADRKPFQGDLQQLKIVCDP 184
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 438-490 3.43e-18

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 79.17  E-value: 3.43e-18
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|...
gi 2217302432   438 WSHWSPWSSCSVTCGDGVITRIRLCNSPSPQMNGKPCEGEARETKACKKDACP 490
Cdd:smart00209    1 WSEWSEWSPCSVTCGGGVQTRTRSCCSPPPQNGGGPCTGEDVETRACNEQPCP 53
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 495-547 4.78e-18

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 78.78  E-value: 4.78e-18
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|...
gi 2217302432   495 WGPWSPWDICSVTCGGGVQKRSRLCNNPTPQFGGKDCVGDVTENQICNKQDCP 547
Cdd:smart00209    1 WSEWSEWSPCSVTCGGGVQTRTRSCCSPPPQNGGGPCTGEDVETRACNEQPCP 53
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 318-372 2.23e-17

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 77.08  E-value: 2.23e-17
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 2217302432  318 CYHNGVQYRNNEEWTVDSCTECHCQNSVTICKKVSCPIMPCSNAT--VPDGECCPRC 372
Cdd:pfam00093    1 CVQNGVVYENGETWKPDLCTICTCDDGKVLCDKIICPPLDCPNPRleIPPGECCPVC 57
TSP_1 pfam00090
Thrombospondin type 1 domain;
439-489 1.90e-16

Thrombospondin type 1 domain;


Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 73.99  E-value: 1.90e-16
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 2217302432  439 SHWSPWSSCSVTCGDGVITRIRLCNSPSPQmnGKPCEGEARETKACKKDAC 489
Cdd:pfam00090    1 SPWSPWSPCSVTCGKGIQVRQRTCKSPFPG--GEPCTGDDIETQACKMDKC 49
TSP_1 pfam00090
Thrombospondin type 1 domain;
496-546 1.02e-14

Thrombospondin type 1 domain;


Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 69.37  E-value: 1.02e-14
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 2217302432  496 GPWSPWDICSVTCGGGVQKRSRLCNNPTPqfGGKDCVGDVTENQICNKQDC 546
Cdd:pfam00090    1 SPWSPWSPCSVTCGKGIQVRQRTCKSPFP--GGEPCTGDDIETQACKMDKC 49
VWC smart00214
von Willebrand factor (vWF) type C domain;
318-372 1.73e-14

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214564  Cd Length: 59  Bit Score: 69.08  E-value: 1.73e-14
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*....
gi 2217302432   318 CYHNGVQYRNNEEWTVDSCTECHCQNSVTI-CKKVSCPIMP-CSNAT--VPDGECCPRC 372
Cdd:smart00214    1 CVHNGRVYNDGETWKPDPCQICTCLDGTTVlCDPVECPPPPdCPNPErvKPPGECCPRC 59
TSP_1 pfam00090
Thrombospondin type 1 domain;
383-428 1.05e-12

Thrombospondin type 1 domain;


Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 63.59  E-value: 1.05e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 2217302432  383 SPWSEWTSCSTSCGNGIQQRGRSCDSL---NNRCEGSSVQTRTCHIQEC 428
Cdd:pfam00090    1 SPWSPWSPCSVTCGKGIQVRQRTCKSPfpgGEPCTGDDIETQACKMDKC 49
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 382-429 3.24e-12

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 62.22  E-value: 3.24e-12
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|...
gi 2217302432   382 WSPWSEWTSCSTSCGNGIQQRGRSCDSLNNR-----CEGSSVQTRTCHIQECD 429
Cdd:smart00209    1 WSEWSEWSPCSVTCGGGVQTRTRSCCSPPPQngggpCTGEDVETRACNEQPCP 53
TSP_3 pfam02412
Thrombospondin type 3 repeat; The thrombospondin repeat is a short aspartate rich repeat which ...
 846-882 2.33e-09

Thrombospondin type 3 repeat; The thrombospondin repeat is a short aspartate rich repeat which binds to calcium ions. The repeat was initially identified in thrombospondin proteins that contained 7 of these repeats. The repeat lacks defined secondary structure.


Pssm-ID: 367074  Cd Length: 36  Bit Score: 53.52  E-value: 2.33e-09
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 2217302432  846 DSDSDRIGDTCDNnqDIDEDGHQNNLDNCPYVPNANQ 882
Cdd:pfam02412    2 DSDSDGVGDACDN--DFDNDGVPDLLDNCPNNANIDQ 36
TSP1_spondin pfam19028
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 439-489 4.17e-09

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


Pssm-ID: 465948  Cd Length: 52  Bit Score: 53.44  E-value: 4.17e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 2217302432  439 SHWSPWSSCSVTCGDGVITRIRLCNSPsPQMNGKPCeGEARETKACKKDAC 489
Cdd:pfam19028    4 SEWSEWSECSVTCGGGVQTRTRTVIVE-PQNGGRPC-PELLERRPCNLPPC 52
TSP1_spondin pfam19028
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 496-546 7.51e-09

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


Pssm-ID: 465948  Cd Length: 52  Bit Score: 52.67  E-value: 7.51e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 2217302432  496 GPWSPWDICSVTCGGGVQKRSRLCNNPtPQFGGKDCvGDVTENQICNKQDC 546
Cdd:pfam19028    4 SEWSEWSECSVTCGGGVQTRTRTVIVE-PQNGGRPC-PELLERRPCNLPPC 52
TSP_3 pfam02412
Thrombospondin type 3 repeat; The thrombospondin repeat is a short aspartate rich repeat which ...
 786-821 1.36e-08

Thrombospondin type 3 repeat; The thrombospondin repeat is a short aspartate rich repeat which binds to calcium ions. The repeat was initially identified in thrombospondin proteins that contained 7 of these repeats. The repeat lacks defined secondary structure.


Pssm-ID: 367074  Cd Length: 36  Bit Score: 51.60  E-value: 1.36e-08
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 2217302432  786 ADTDNNGEGDACAADIDGDGILNERDNCQYVYNVDQ 821
Cdd:pfam02412    1 TDSDSDGVGDACDNDFDNDGVPDLLDNCPNNANIDQ 36
TSP_3 pfam02412
Thrombospondin type 3 repeat; The thrombospondin repeat is a short aspartate rich repeat which ...
 919-952 2.19e-07

Thrombospondin type 3 repeat; The thrombospondin repeat is a short aspartate rich repeat which binds to calcium ions. The repeat was initially identified in thrombospondin proteins that contained 7 of these repeats. The repeat lacks defined secondary structure.


Pssm-ID: 367074  Cd Length: 36  Bit Score: 48.13  E-value: 2.19e-07
                           10        20        30
                   ....*....|....*....|....*....|....
gi 2217302432  919 KDSDGDGRGDACKDDFDHDSVPDIDDICPENVDI 952
Cdd:pfam02412    1 TDSDSDGVGDACDNDFDNDGVPDLLDNCPNNANI 34
TSP1_spondin pfam19028
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 383-428 5.65e-07

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


Pssm-ID: 465948  Cd Length: 52  Bit Score: 47.27  E-value: 5.65e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 2217302432  383 SPWSEWTSCSTSCGNGIQQR-----------GRSCDSLnnrcegssVQTRTCHIQEC 428
Cdd:pfam19028    4 SEWSEWSECSVTCGGGVQTRtrtvivepqngGRPCPEL--------LERRPCNLPPC 52
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 650-689 1.21e-06

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 46.05  E-value: 1.21e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 2217302432  650 CTDGTHDCNKNAKCNYlghySDPMYRCECKPGYAGNGIIC 689
Cdd:pfam12947    1 CSDNNGGCHPNATCTN----TGGSFTCTCNDGYTGDGVTC 36
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 496-546 8.41e-05

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 41.28  E-value: 8.41e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 2217302432  496 GPWSPwdiCSVTCGGGVQKRSRLCNNPTPQ--FGGKDCVGDV--TENQICNKQDC 546
Cdd:pfam19030    4 GPWGE---CSVTCGGGVQTRLVQCVQKGGGsiVPDSECSAQKkpPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 443-489 1.21e-03

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 38.20  E-value: 1.21e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 2217302432  443 PWSSCSVTCGDGVITRIRLCNSPSPQ--MNGKPCEGEAR--ETKACKKDAC 489
Cdd:pfam19030    5 PWGECSVTCGGGVQTRLVQCVQKGGGsiVPDSECSAQKKppETQSCNLKPC 55
PTZ00441 PTZ00441
sporozoite surface protein 2 (SSP2); Provisional
 496-517 2.60e-03

sporozoite surface protein 2 (SSP2); Provisional


Pssm-ID: 240420 [Multi-domain]  Cd Length: 576  Bit Score: 41.87  E-value: 2.60e-03
                           10        20
                   ....*....|....*....|..
gi 2217302432  496 GPWSPWDICSVTCGGGVQKRSR 517
Cdd:PTZ00441   241 GPWDEWTPCSVTCGKGTHSRSR 262
VWC_out smart00215
von Willebrand factor (vWF) type C domain;
318-385 3.19e-03

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214565  Cd Length: 67  Bit Score: 37.16  E-value: 3.19e-03
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2217302432   318 CYHNGVQYRNNEEWtVDSCTECHCQNSVTICKKVSCPIMPCSNATVpDGECCPRCWPSDSADDGWSPW 385
Cdd:smart00215    1 CWNNGSYYPPGAKW-DDDCNRCTCLNGRVSCTKVWCGPKPCLLHNL-SGECPLGQGCVPSLSDCLSSP 66
Amnionless pfam14828
Amnionless; The amnionless protein forms a complex with cubilin. This complex is necessary for ...
 324-372 5.67e-03

Amnionless; The amnionless protein forms a complex with cubilin. This complex is necessary for vitamin B12 uptake.


Pssm-ID: 464340  Cd Length: 449  Bit Score: 40.45  E-value: 5.67e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 2217302432  324 QYRNNEEWTVDS-----CTECHCQNSVT---ICKKVS--CPIMPCSNATVPDGECCPRC 372
Cdd:pfam14828  177 QFHGAGALRVGPeacsdPSGCGCGNDENlerICANVLqrCPPPHCLSPLRPEGHCCDVC 235
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 124-217 5.79e-03

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 38.17  E-value: 5.79e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217302432  124 KAGTLDLSLTVQGKQHVVSVEEALLATGQWKSITLFVQEDRAQLYID-CEKMENAELDVPIQSVFTRDL---ASIARLRI 199
Cdd:pfam02210   26 VNGRLVLRYDLGSGPESLLSSGKNLNDGQWHSVRVERNGNTLTLSVDgQTVVSSLPPGESLLLNLNGPLylgGLPPLLLL 105

                           90
                   ....*....|....*...
gi 2217302432  200 AKGGVNDNFQGVLQNVRF 217
Cdd:pfam02210  106 PALPVRAGFVGCIRDVRV 123
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 124-217 9.33e-03

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 38.17  E-value: 9.33e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217302432  124 KAGTLDLSLTVQGKQHVVSVEEaLLATGQWKSITLFVQEDRAQLYIDCEKMENAELDVPIQSVFTRDL----ASIARLRI 199
Cdd:cd00110     54 EDGRLVLRYDLGSGSLVLSSKT-PLNDGQWHSVSVERNGRSVTLSVDGERVVESGSPGGSALLNLDGPlylgGLPEDLKS 132

                           90
                   ....*....|....*...
gi 2217302432  200 AKGGVNDNFQGVLQNVRF 217
Cdd:cd00110    133 PGLPVSPGFVGCIRDLKV 150
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH