|
Name |
Accession |
Description |
Interval |
E-value |
| INB |
smart00187 |
Integrin beta subunits (N-terminal portion of extracellular region); Portion of beta integrins ... |
72-488 |
0e+00 |
|
Integrin beta subunits (N-terminal portion of extracellular region); Portion of beta integrins that lies N-terminal to their EGF-like repeats. Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Beta integrins are proposed to have a von Willebrand factor type-A "insert" or "I" -like domain (although this remains to be confirmed).
:
Pssm-ID: 197563 [Multi-domain] Cd Length: 423 Bit Score: 617.03 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311584 72 SCTECVRVDKDCAYCTDEMFRDR---RCNTQAELLAAGCQRESIVVMESSFQITEETQID---TTLRRSQMSPQGLRVRL 145
Cdd:smart00187 1 SCEECIQSGPNCAWCTDENFTSGgsaRCDTRANLLAKGCSPESIENPASSAEVLEDKPLSdkgSGGQAVQVSPQRVRLKL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311584 146 RPGEERHFELEVFEPLESPVDLYILMDFSNSMSDDLDNLKKMGQNLARVLSQLTSDYTIGFGKFVDKVSVPQTDMRPEKL 225
Cdd:smart00187 81 RPGEPQNFTLTVRQAEDYPVDLYYLMDLSYSMKDDLDNLKSLGDDLAREMKGLTSNFRLGFGSFVDKTVSPFVSTHPEKL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311584 226 KEPWPN----SDPPFSFKNVISLTEDVDEFRNKLQGERISGNLDAPEGGFDAILQTAVCTRDIGWRPDSTHLLVFSTESA 301
Cdd:smart00187 161 ENPCPNynktCEPPYGFKHVLSLTDDTDEFNEEVGKQRISGNLDAPEGGFDAIMQAAVCTEQIGWREDARRLLVFSTDAG 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311584 302 FHYEADGAnvLAGIMSRNDERCHLDTTGTYTQYRTQDYPSVPTLVRLLAKHNIIPIFAVTNYSYSYYEKLHTYFPVSSLG 381
Cdd:smart00187 241 FHFAGDGK--LGGIVTPNDGQCHLDNNGEYTMSTTQDYPSIGQLAQKLAENNINPIFAVTKKQVSLYKELSALIPGSSVG 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311584 382 VLQEDSSNIVELLEEAFNRIRSNLDIRALDSPRGLRTEVTSkMFQKTRTGSFHirRGEVGIYQVQLRALEHVDGTHVCQl 461
Cdd:smart00187 319 ELSEDSSNVVELIKDAYNKISSRVELEDNALPEGVSVTYTS-SCPGGVTGPGT--RKCEGVKIGDTVSFEVTVTATKCP- 394
|
410 420
....*....|....*....|....*...
gi 2217311584 462 PEDQKGNIHLKP-SFSDGLKMDAGIICD 488
Cdd:smart00187 395 PEDQEQSIRIRPvGFSETLEVEVTFLCD 422
|
|
| Integrin_B_tail |
pfam07965 |
Integrin beta tail domain; This is the beta tail domain of the Integrin protein. Integrins are ... |
661-744 |
2.06e-27 |
|
Integrin beta tail domain; This is the beta tail domain of the Integrin protein. Integrins are receptors which are involved in cell-cell and cell-extracellular matrix interactions.
:
Pssm-ID: 462325 Cd Length: 84 Bit Score: 106.98 E-value: 2.06e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311584 661 CEDLRSCVQCQAWGTGEKKGRTC-EECNFKVKMVDELKRAEE-VVVRCSFRDEdDDCTYSYTMEGDgaPGPNSTVLVHKK 738
Cdd:pfam07965 1 CEEKKSCVECQAFKTGPLKEKNCsRNCKFEIILVEVLKEDEEpGAVLCSFKDE-DDCWFTFTYYED--ESGKYVVHVQKE 77
|
....*.
gi 2217311584 739 KDCPPG 744
Cdd:pfam07965 78 RECPPG 83
|
|
| Calx-beta |
pfam03160 |
Calx-beta domain; |
1025-1119 |
3.62e-25 |
|
Calx-beta domain;
:
Pssm-ID: 397326 [Multi-domain] Cd Length: 91 Bit Score: 101.17 E-value: 3.62e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311584 1025 DVVSFEQPEFSVSRGDQVARIPVIRRVLD-GGKSQVSYRTQDGTAQGNRDYIPVEGELLFQPGEAWKELQVKLLElqevD 1103
Cdd:pfam03160 2 GVIGFEPPTYQVSENDGVAEVCVVRMSGTlRRTVVVPYRTEDGTATAGDDYEPVEGELVFGPGETEKCINVTIID----D 77
|
90
....*....|....*.
gi 2217311584 1104 SLLRGRqvRRFHVQLS 1119
Cdd:pfam03160 78 DVYEGD--ENFFVLLS 91
|
|
| fn3 |
pfam00041 |
Fibronectin type III domain; |
1730-1815 |
2.86e-21 |
|
Fibronectin type III domain;
:
Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 89.78 E-value: 2.86e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311584 1730 SAPGPLVFTALSPDSLQLSWERPRRPNGDIVGYLVTCEMAQGGGPATAFRVDGDspESRLTVPGLSENVPYKFKVQARTT 1809
Cdd:pfam00041 1 SAPSNLTVTDVTSTSLTVSWTPPPDGNGPITGYEVEYRPKNSGEPWNEITVPGT--TTSVTLTGLKPGTEYEVRVQAVNG 78
|
....*.
gi 2217311584 1810 EGFGPE 1815
Cdd:pfam00041 79 GGEGPP 84
|
|
| fn3 |
pfam00041 |
Fibronectin type III domain; |
1617-1699 |
2.18e-19 |
|
Fibronectin type III domain;
:
Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 84.39 E-value: 2.18e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311584 1617 DTPTRLVFSALGPTSLRVSWQEPR-CERPLQGYSVEYQLLNGGE-LHRLNIPNPaQTSVVVEDLLPNHSYVFRVRAQSQE 1694
Cdd:pfam00041 1 SAPSNLTVTDVTSTSLTVSWTPPPdGNGPITGYEVEYRPKNSGEpWNEITVPGT-TTSVTLTGLKPGTEYEVRVQAVNGG 79
|
....*
gi 2217311584 1695 GWGRE 1699
Cdd:pfam00041 80 GEGPP 84
|
|
| fn3 |
pfam00041 |
Fibronectin type III domain; |
1163-1243 |
6.98e-16 |
|
Fibronectin type III domain;
:
Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 74.37 E-value: 6.98e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311584 1163 GAPQNPNAKAAGSRKIHFNWLPP---SGKPMGYRVKYWIQGDSESEAHLLDSKVP-SVELTNLYPYCDYEMKVCAYGAQG 1238
Cdd:pfam00041 1 SAPSNLTVTDVTSTSLTVSWTPPpdgNGPITGYEVEYRPKNSGEPWNEITVPGTTtSVTLTGLKPGTEYEVRVQAVNGGG 80
|
....*
gi 2217311584 1239 EGPYS 1243
Cdd:pfam00041 81 EGPPS 85
|
|
| fn3 |
pfam00041 |
Fibronectin type III domain; |
1256-1344 |
3.68e-14 |
|
Fibronectin type III domain;
:
Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 69.37 E-value: 3.68e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311584 1256 SEPGRLAFNVVSSTVTQLSWAEPAETNGEITAYEVCYGLVNDdnrpIGPMKKVLVDNPKNRMLLiENLRESQPYRYTVKA 1335
Cdd:pfam00041 1 SAPSNLTVTDVTSTSLTVSWTPPPDGNGPITGYEVEYRPKNS----GEPWNEITVPGTTTSVTL-TGLKPGTEYEVRVQA 75
|
....*....
gi 2217311584 1336 RNGAGWGPE 1344
Cdd:pfam00041 76 VNGGGEGPP 84
|
|
| I-EGF_1 |
pfam18372 |
Integrin beta epidermal growth factor like domain 1; This is the I-EGF 1 domain found in ... |
492-520 |
1.76e-10 |
|
Integrin beta epidermal growth factor like domain 1; This is the I-EGF 1 domain found in several integrin betas such as integrin beta 1-7. Structural analysis reveal an epidermal growth factor-like (I-EGF) domains 1 and 2. EGF1 lacks one disulfide (C2-C4) relative to the integrin EGF 2, 3, and 4 domains, this allows the C-terminal end of EGF1 to flex remarkably relative to its N-terminal end.
:
Pssm-ID: 465729 Cd Length: 29 Bit Score: 57.11 E-value: 1.76e-10
10 20
....*....|....*....|....*....
gi 2217311584 492 CELQKEVRSARCSFNGDFVCGQCVCSEGW 520
Cdd:pfam18372 1 CEKQAEPNSPRCSGNGTFVCGVCVCNPGY 29
|
|
| EGF_2 |
pfam07974 |
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins. |
585-608 |
1.16e-03 |
|
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
:
Pssm-ID: 400365 Cd Length: 26 Bit Score: 38.10 E-value: 1.16e-03
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| INB |
smart00187 |
Integrin beta subunits (N-terminal portion of extracellular region); Portion of beta integrins ... |
72-488 |
0e+00 |
|
Integrin beta subunits (N-terminal portion of extracellular region); Portion of beta integrins that lies N-terminal to their EGF-like repeats. Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Beta integrins are proposed to have a von Willebrand factor type-A "insert" or "I" -like domain (although this remains to be confirmed).
Pssm-ID: 197563 [Multi-domain] Cd Length: 423 Bit Score: 617.03 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311584 72 SCTECVRVDKDCAYCTDEMFRDR---RCNTQAELLAAGCQRESIVVMESSFQITEETQID---TTLRRSQMSPQGLRVRL 145
Cdd:smart00187 1 SCEECIQSGPNCAWCTDENFTSGgsaRCDTRANLLAKGCSPESIENPASSAEVLEDKPLSdkgSGGQAVQVSPQRVRLKL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311584 146 RPGEERHFELEVFEPLESPVDLYILMDFSNSMSDDLDNLKKMGQNLARVLSQLTSDYTIGFGKFVDKVSVPQTDMRPEKL 225
Cdd:smart00187 81 RPGEPQNFTLTVRQAEDYPVDLYYLMDLSYSMKDDLDNLKSLGDDLAREMKGLTSNFRLGFGSFVDKTVSPFVSTHPEKL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311584 226 KEPWPN----SDPPFSFKNVISLTEDVDEFRNKLQGERISGNLDAPEGGFDAILQTAVCTRDIGWRPDSTHLLVFSTESA 301
Cdd:smart00187 161 ENPCPNynktCEPPYGFKHVLSLTDDTDEFNEEVGKQRISGNLDAPEGGFDAIMQAAVCTEQIGWREDARRLLVFSTDAG 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311584 302 FHYEADGAnvLAGIMSRNDERCHLDTTGTYTQYRTQDYPSVPTLVRLLAKHNIIPIFAVTNYSYSYYEKLHTYFPVSSLG 381
Cdd:smart00187 241 FHFAGDGK--LGGIVTPNDGQCHLDNNGEYTMSTTQDYPSIGQLAQKLAENNINPIFAVTKKQVSLYKELSALIPGSSVG 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311584 382 VLQEDSSNIVELLEEAFNRIRSNLDIRALDSPRGLRTEVTSkMFQKTRTGSFHirRGEVGIYQVQLRALEHVDGTHVCQl 461
Cdd:smart00187 319 ELSEDSSNVVELIKDAYNKISSRVELEDNALPEGVSVTYTS-SCPGGVTGPGT--RKCEGVKIGDTVSFEVTVTATKCP- 394
|
410 420
....*....|....*....|....*...
gi 2217311584 462 PEDQKGNIHLKP-SFSDGLKMDAGIICD 488
Cdd:smart00187 395 PEDQEQSIRIRPvGFSETLEVEVTFLCD 422
|
|
| Integrin_beta |
pfam00362 |
Integrin beta chain VWA domain; Integrins have been found in animals and their homologs have ... |
160-405 |
2.97e-149 |
|
Integrin beta chain VWA domain; Integrins have been found in animals and their homologs have also been found in cyanobacteria, probably due to horizontal gene transfer. This domain corresponds to the integrin beta VWA domain.
Pssm-ID: 459781 Cd Length: 248 Bit Score: 459.27 E-value: 2.97e-149
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311584 160 PLESPVDLYILMDFSNSMSDDLDNLKKMGQNLARVLSQLTSDYTIGFGKFVDKVSVPQTDMRPEKLKEPWPNS----DPP 235
Cdd:pfam00362 1 AEDYPVDLYYLMDLSYSMKDDLDNLKKLGNDLAEEMRNITSNFRLGFGSFVDKPVMPYISTRPEKLKNPCPGEneqcDPP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311584 236 FSFKNVISLTEDVDEFRNKLQGERISGNLDAPEGGFDAILQTAVCTRDIGWRPDSTHLLVFSTESAFHYEADGAnvLAGI 315
Cdd:pfam00362 81 FGFRHVLSLTNDIEEFTEEVQKQRISGNLDAPEGGFDAIMQAAVCKDQIGWRNEARRLLVFSTDAGFHYAGDGK--LAGI 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311584 316 MSRNDERCHLDTTGTYTQYRTQDYPSVPTLVRLLAKHNIIPIFAVTNYSYSYYEKLHTYFPVSSLGVLQEDSSNIVELLE 395
Cdd:pfam00362 159 VTPNDGQCHLDSNGEYTKSTEQDYPSLGQLVRKLSENNINPIFAVTEEQYSLYEKLSKLIPGSSVGVLSEDSSNIVQLIK 238
|
250
....*....|
gi 2217311584 396 EAFNRIRSNL 405
Cdd:pfam00362 239 EAYEKIRSKV 248
|
|
| Integrin_B_tail |
pfam07965 |
Integrin beta tail domain; This is the beta tail domain of the Integrin protein. Integrins are ... |
661-744 |
2.06e-27 |
|
Integrin beta tail domain; This is the beta tail domain of the Integrin protein. Integrins are receptors which are involved in cell-cell and cell-extracellular matrix interactions.
Pssm-ID: 462325 Cd Length: 84 Bit Score: 106.98 E-value: 2.06e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311584 661 CEDLRSCVQCQAWGTGEKKGRTC-EECNFKVKMVDELKRAEE-VVVRCSFRDEdDDCTYSYTMEGDgaPGPNSTVLVHKK 738
Cdd:pfam07965 1 CEEKKSCVECQAFKTGPLKEKNCsRNCKFEIILVEVLKEDEEpGAVLCSFKDE-DDCWFTFTYYED--ESGKYVVHVQKE 77
|
....*.
gi 2217311584 739 KDCPPG 744
Cdd:pfam07965 78 RECPPG 83
|
|
| Calx-beta |
pfam03160 |
Calx-beta domain; |
1025-1119 |
3.62e-25 |
|
Calx-beta domain;
Pssm-ID: 397326 [Multi-domain] Cd Length: 91 Bit Score: 101.17 E-value: 3.62e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311584 1025 DVVSFEQPEFSVSRGDQVARIPVIRRVLD-GGKSQVSYRTQDGTAQGNRDYIPVEGELLFQPGEAWKELQVKLLElqevD 1103
Cdd:pfam03160 2 GVIGFEPPTYQVSENDGVAEVCVVRMSGTlRRTVVVPYRTEDGTATAGDDYEPVEGELVFGPGETEKCINVTIID----D 77
|
90
....*....|....*.
gi 2217311584 1104 SLLRGRqvRRFHVQLS 1119
Cdd:pfam03160 78 DVYEGD--ENFFVLLS 91
|
|
| Calx_beta |
smart00237 |
Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin ... |
1026-1119 |
2.89e-23 |
|
Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin subunit beta4 (and some cyanobacterial proteins)
Pssm-ID: 197594 [Multi-domain] Cd Length: 90 Bit Score: 95.40 E-value: 2.89e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311584 1026 VVSFEQPEFSVSRGDQVARIPVIRRVLDGGKSQVSYRTQDGTAQGNRDYIPVEGELLFQPGEAWKELQVKLLelqeVDSL 1105
Cdd:smart00237 3 SVGFEQPVYTVSESDGEVEVCVVRTGGARGPVVVPYSTEDGTATAGSDYEPVPGELTFPPGETEKEIRIKII----DDDI 78
|
90
....*....|....
gi 2217311584 1106 LRGrqVRRFHVQLS 1119
Cdd:smart00237 79 YEK--DETFYVRLS 90
|
|
| fn3 |
pfam00041 |
Fibronectin type III domain; |
1730-1815 |
2.86e-21 |
|
Fibronectin type III domain;
Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 89.78 E-value: 2.86e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311584 1730 SAPGPLVFTALSPDSLQLSWERPRRPNGDIVGYLVTCEMAQGGGPATAFRVDGDspESRLTVPGLSENVPYKFKVQARTT 1809
Cdd:pfam00041 1 SAPSNLTVTDVTSTSLTVSWTPPPDGNGPITGYEVEYRPKNSGEPWNEITVPGT--TTSVTLTGLKPGTEYEVRVQAVNG 78
|
....*.
gi 2217311584 1810 EGFGPE 1815
Cdd:pfam00041 79 GGEGPP 84
|
|
| fn3 |
pfam00041 |
Fibronectin type III domain; |
1617-1699 |
2.18e-19 |
|
Fibronectin type III domain;
Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 84.39 E-value: 2.18e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311584 1617 DTPTRLVFSALGPTSLRVSWQEPR-CERPLQGYSVEYQLLNGGE-LHRLNIPNPaQTSVVVEDLLPNHSYVFRVRAQSQE 1694
Cdd:pfam00041 1 SAPSNLTVTDVTSTSLTVSWTPPPdGNGPITGYEVEYRPKNSGEpWNEITVPGT-TTSVTLTGLKPGTEYEVRVQAVNGG 79
|
....*
gi 2217311584 1695 GWGRE 1699
Cdd:pfam00041 80 GEGPP 84
|
|
| FN3 |
cd00063 |
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
1616-1697 |
2.52e-19 |
|
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 84.47 E-value: 2.52e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311584 1616 PDTPTRLVFSALGPTSLRVSWQEPRCE-RPLQGYSVEYQLLNGGELHRLNIPNPAQTSVVVEDLLPNHSYVFRVRAQSQE 1694
Cdd:cd00063 1 PSPPTNLRVTDVTSTSVTLSWTPPEDDgGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGG 80
|
...
gi 2217311584 1695 GWG 1697
Cdd:cd00063 81 GES 83
|
|
| FN3 |
cd00063 |
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
1729-1814 |
4.79e-17 |
|
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 77.92 E-value: 4.79e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311584 1729 PSAPGPLVFTALSPDSLQLSWERPRRPNGDIVGYLVTCEMAQGGGPATAFRVDGDspESRLTVPGLSENVPYKFKVQART 1808
Cdd:cd00063 1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSGDWKEVEVTPGS--ETSYTLTGLKPGTEYEFRVRAVN 78
|
....*.
gi 2217311584 1809 TEGFGP 1814
Cdd:cd00063 79 GGGESP 84
|
|
| fn3 |
pfam00041 |
Fibronectin type III domain; |
1163-1243 |
6.98e-16 |
|
Fibronectin type III domain;
Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 74.37 E-value: 6.98e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311584 1163 GAPQNPNAKAAGSRKIHFNWLPP---SGKPMGYRVKYWIQGDSESEAHLLDSKVP-SVELTNLYPYCDYEMKVCAYGAQG 1238
Cdd:pfam00041 1 SAPSNLTVTDVTSTSLTVSWTPPpdgNGPITGYEVEYRPKNSGEPWNEITVPGTTtSVTLTGLKPGTEYEVRVQAVNGGG 80
|
....*
gi 2217311584 1239 EGPYS 1243
Cdd:pfam00041 81 EGPPS 85
|
|
| FN3 |
smart00060 |
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ... |
1616-1697 |
2.55e-15 |
|
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.
Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 72.65 E-value: 2.55e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311584 1616 PDTPTRLVFSALGPTSLRVSWQEPRcERPLQGYSVEYQLLNGGELHRLN--IPNPAQTSVVVEDLLPNHSYVFRVRAQSQ 1693
Cdd:smart00060 1 PSPPSNLRVTDVTSTSVTLSWEPPP-DDGITGYIVGYRVEYREEGSEWKevNVTPSSTSYTLTGLKPGTEYEFRVRAVNG 79
|
....
gi 2217311584 1694 EGWG 1697
Cdd:smart00060 80 AGEG 83
|
|
| FN3 |
smart00060 |
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ... |
1729-1813 |
1.31e-14 |
|
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.
Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 70.72 E-value: 1.31e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311584 1729 PSAPGPLVFTALSPDSLQLSWERPRRPNGDivGYLVTCEMAQGGGPATAFRVDGDSPESRLTVPGLSENVPYKFKVQART 1808
Cdd:smart00060 1 PSPPSNLRVTDVTSTSVTLSWEPPPDDGIT--GYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVN 78
|
....*
gi 2217311584 1809 TEGFG 1813
Cdd:smart00060 79 GAGEG 83
|
|
| fn3 |
pfam00041 |
Fibronectin type III domain; |
1256-1344 |
3.68e-14 |
|
Fibronectin type III domain;
Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 69.37 E-value: 3.68e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311584 1256 SEPGRLAFNVVSSTVTQLSWAEPAETNGEITAYEVCYGLVNDdnrpIGPMKKVLVDNPKNRMLLiENLRESQPYRYTVKA 1335
Cdd:pfam00041 1 SAPSNLTVTDVTSTSLTVSWTPPPDGNGPITGYEVEYRPKNS----GEPWNEITVPGTTTSVTL-TGLKPGTEYEVRVQA 75
|
....*....
gi 2217311584 1336 RNGAGWGPE 1344
Cdd:pfam00041 76 VNGGGEGPP 84
|
|
| FN3 |
cd00063 |
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
1255-1348 |
4.63e-14 |
|
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 69.45 E-value: 4.63e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311584 1255 PSEPGRLAFNVVSSTVTQLSWAEPAETNGEITAYEVCYGLVNDDNrpigpMKKVLVDNPKNRMLLIENLRESQPYRYTVK 1334
Cdd:cd00063 1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSGD-----WKEVEVTPGSETSYTLTGLKPGTEYEFRVR 75
|
90
....*....|....
gi 2217311584 1335 ARNGAGWGPEREAI 1348
Cdd:cd00063 76 AVNGGGESPPSESV 89
|
|
| FN3 |
COG3401 |
Fibronectin type 3 domain [General function prediction only]; |
1615-1834 |
5.94e-14 |
|
Fibronectin type 3 domain [General function prediction only];
Pssm-ID: 442628 [Multi-domain] Cd Length: 603 Bit Score: 76.96 E-value: 5.94e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311584 1615 VPDTPTRLVFSALGPTSLRVSWQEPRcERPLQGYSVEYQLLNGGELHRlnIPNPAQTSVVVEDLLPNHSYVFRVRAQSQE 1694
Cdd:COG3401 232 PPSAPTGLTATADTPGSVTLSWDPVT-ESDATGYRVYRSNSGDGPFTK--VATVTTTSYTDTGLTNGTTYYYRVTAVDAA 308
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311584 1695 GwgreregvitIESqvhPQSPlcplPGSAFT-LSTPSAPGPLVFTALSPDSLQLSWERPrrPNGDIVGYLVTcemaQGGG 1773
Cdd:COG3401 309 G----------NES---APSN----VVSVTTdLTPPAAPSGLTATAVGSSSITLSWTAS--SDADVTGYNVY----RSTS 365
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2217311584 1774 PATAFRVDGDSP-ESRLTVPGLSENVPYKFKVQARTTEGFGPEREGIITIESQDGGPFPQLG 1834
Cdd:COG3401 366 GGGTYTKIAETVtTTSYTDTGLTPGTTYYYKVTAVDAAGNESAPSEEVSATTASAASGESLT 427
|
|
| FN3 |
cd00063 |
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
1163-1250 |
3.44e-13 |
|
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 67.14 E-value: 3.44e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311584 1163 GAPQNPNAKAAGSRKIHFNWLPPS---GKPMGYRVKYWIQGDSE-SEAHLLDSKVPSVELTNLYPYCDYEMKVCAYGAQG 1238
Cdd:cd00063 2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDwKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81
|
90
....*....|..
gi 2217311584 1239 EGPYSSLVSCRT 1250
Cdd:cd00063 82 ESPPSESVTVTT 93
|
|
| I-EGF_1 |
pfam18372 |
Integrin beta epidermal growth factor like domain 1; This is the I-EGF 1 domain found in ... |
492-520 |
1.76e-10 |
|
Integrin beta epidermal growth factor like domain 1; This is the I-EGF 1 domain found in several integrin betas such as integrin beta 1-7. Structural analysis reveal an epidermal growth factor-like (I-EGF) domains 1 and 2. EGF1 lacks one disulfide (C2-C4) relative to the integrin EGF 2, 3, and 4 domains, this allows the C-terminal end of EGF1 to flex remarkably relative to its N-terminal end.
Pssm-ID: 465729 Cd Length: 29 Bit Score: 57.11 E-value: 1.76e-10
10 20
....*....|....*....|....*....
gi 2217311584 492 CELQKEVRSARCSFNGDFVCGQCVCSEGW 520
Cdd:pfam18372 1 CEKQAEPNSPRCSGNGTFVCGVCVCNPGY 29
|
|
| caca |
TIGR00845 |
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ... |
1027-1141 |
5.97e-10 |
|
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]
Pssm-ID: 273296 [Multi-domain] Cd Length: 928 Bit Score: 64.43 E-value: 5.97e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311584 1027 VSFEQPEFSVSRGDQVARIPVIRRVLDGGKS-QVSYRTQDGTAQGNRDYIPVEGELLFQPGEAWKELQVKLL--ELQEVD 1103
Cdd:TIGR00845 402 IFFEPGHYTCLENCGTVALTVVRRGGDLTNTvYVDYRTEDGTANAGSDYEFTEGTLVFKPGETQKEFRIGIIddDIFEED 481
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 2217311584 1104 sllrgrqvRRFHVQLSNPKFG--------------AHLGQPHSTTIIIRDPD 1141
Cdd:TIGR00845 482 --------EHFYVRLSNLRVGsedgileanhvsavAQLASPNTATVTILDDD 525
|
|
| FN3 |
smart00060 |
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ... |
1163-1240 |
2.15e-09 |
|
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.
Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 55.70 E-value: 2.15e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311584 1163 GAPQNPNAKAAGSRKIHFNWLPP-SGKPMGYRVKYWIQGDSESEA---HLLDSKVPSVELTNLYPYCDYEMKVCAYGAQG 1238
Cdd:smart00060 2 SPPSNLRVTDVTSTSVTLSWEPPpDDGITGYIVGYRVEYREEGSEwkeVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81
|
..
gi 2217311584 1239 EG 1240
Cdd:smart00060 82 EG 83
|
|
| FN3 |
smart00060 |
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ... |
1255-1342 |
2.86e-09 |
|
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.
Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 55.70 E-value: 2.86e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311584 1255 PSEPGRLAFNVVSSTVTQLSWAEPAETNGeiTAYEVCYGLVNddnRPIGPMKKVLVDNPKNRMLLIENLRESQPYRYTVK 1334
Cdd:smart00060 1 PSPPSNLRVTDVTSTSVTLSWEPPPDDGI--TGYIVGYRVEY---REEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVR 75
|
....*...
gi 2217311584 1335 ARNGAGWG 1342
Cdd:smart00060 76 AVNGAGEG 83
|
|
| FN3 |
COG3401 |
Fibronectin type 3 domain [General function prediction only]; |
1667-1811 |
3.67e-08 |
|
Fibronectin type 3 domain [General function prediction only];
Pssm-ID: 442628 [Multi-domain] Cd Length: 603 Bit Score: 58.48 E-value: 3.67e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311584 1667 NPAQTSVVVEDLLPNHSYVFRVRAQSQEGWGREREGVitiesqvhpqsplcplpgSAFTLST-PSAPGPLVFTALSPDSL 1745
Cdd:COG3401 188 TSTTLVDGGGDIEPGTTYYYRVAATDTGGESAPSNEV------------------SVTTPTTpPSAPTGLTATADTPGSV 249
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2217311584 1746 QLSWERPrrPNGDIVGYLVtcemAQGGGPATAFRVDGDSPESRLTVPGLSENVPYKFKVQARTTEG 1811
Cdd:COG3401 250 TLSWDPV--TESDATGYRV----YRSNSGDGPFTKVATVTTTSYTDTGLTNGTTYYYRVTAVDAAG 309
|
|
| FN3 |
COG3401 |
Fibronectin type 3 domain [General function prediction only]; |
1181-1340 |
2.15e-06 |
|
Fibronectin type 3 domain [General function prediction only];
Pssm-ID: 442628 [Multi-domain] Cd Length: 603 Bit Score: 52.70 E-value: 2.15e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311584 1181 NWLPPSGKPMGYRVKYWIQGDSESEAHLLDSKVPSVELTNLYPYCDYEMKVCAYGAQGEGPYSSLVSCRTHQEVPSEPGR 1260
Cdd:COG3401 159 TASSVAGAGVVVSPDTSATAAVATTSLTVTSTTLVDGGGDIEPGTTYYYRVAATDTGGESAPSNEVSVTTPTTPPSAPTG 238
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311584 1261 LAFNVVSSTVTQLSWAEPAETNgeITAYEVCYGLVNDdnrpiGPMKKvlVDNPKNRMLLIENLRESQPYRYTVKARNGAG 1340
Cdd:COG3401 239 LTATADTPGSVTLSWDPVTESD--ATGYRVYRSNSGD-----GPFTK--VATVTTTSYTDTGLTNGTTYYYRVTAVDAAG 309
|
|
| EGF_2 |
pfam07974 |
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins. |
585-608 |
1.16e-03 |
|
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
Pssm-ID: 400365 Cd Length: 26 Bit Score: 38.10 E-value: 1.16e-03
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| INB |
smart00187 |
Integrin beta subunits (N-terminal portion of extracellular region); Portion of beta integrins ... |
72-488 |
0e+00 |
|
Integrin beta subunits (N-terminal portion of extracellular region); Portion of beta integrins that lies N-terminal to their EGF-like repeats. Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Beta integrins are proposed to have a von Willebrand factor type-A "insert" or "I" -like domain (although this remains to be confirmed).
Pssm-ID: 197563 [Multi-domain] Cd Length: 423 Bit Score: 617.03 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311584 72 SCTECVRVDKDCAYCTDEMFRDR---RCNTQAELLAAGCQRESIVVMESSFQITEETQID---TTLRRSQMSPQGLRVRL 145
Cdd:smart00187 1 SCEECIQSGPNCAWCTDENFTSGgsaRCDTRANLLAKGCSPESIENPASSAEVLEDKPLSdkgSGGQAVQVSPQRVRLKL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311584 146 RPGEERHFELEVFEPLESPVDLYILMDFSNSMSDDLDNLKKMGQNLARVLSQLTSDYTIGFGKFVDKVSVPQTDMRPEKL 225
Cdd:smart00187 81 RPGEPQNFTLTVRQAEDYPVDLYYLMDLSYSMKDDLDNLKSLGDDLAREMKGLTSNFRLGFGSFVDKTVSPFVSTHPEKL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311584 226 KEPWPN----SDPPFSFKNVISLTEDVDEFRNKLQGERISGNLDAPEGGFDAILQTAVCTRDIGWRPDSTHLLVFSTESA 301
Cdd:smart00187 161 ENPCPNynktCEPPYGFKHVLSLTDDTDEFNEEVGKQRISGNLDAPEGGFDAIMQAAVCTEQIGWREDARRLLVFSTDAG 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311584 302 FHYEADGAnvLAGIMSRNDERCHLDTTGTYTQYRTQDYPSVPTLVRLLAKHNIIPIFAVTNYSYSYYEKLHTYFPVSSLG 381
Cdd:smart00187 241 FHFAGDGK--LGGIVTPNDGQCHLDNNGEYTMSTTQDYPSIGQLAQKLAENNINPIFAVTKKQVSLYKELSALIPGSSVG 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311584 382 VLQEDSSNIVELLEEAFNRIRSNLDIRALDSPRGLRTEVTSkMFQKTRTGSFHirRGEVGIYQVQLRALEHVDGTHVCQl 461
Cdd:smart00187 319 ELSEDSSNVVELIKDAYNKISSRVELEDNALPEGVSVTYTS-SCPGGVTGPGT--RKCEGVKIGDTVSFEVTVTATKCP- 394
|
410 420
....*....|....*....|....*...
gi 2217311584 462 PEDQKGNIHLKP-SFSDGLKMDAGIICD 488
Cdd:smart00187 395 PEDQEQSIRIRPvGFSETLEVEVTFLCD 422
|
|
| Integrin_beta |
pfam00362 |
Integrin beta chain VWA domain; Integrins have been found in animals and their homologs have ... |
160-405 |
2.97e-149 |
|
Integrin beta chain VWA domain; Integrins have been found in animals and their homologs have also been found in cyanobacteria, probably due to horizontal gene transfer. This domain corresponds to the integrin beta VWA domain.
Pssm-ID: 459781 Cd Length: 248 Bit Score: 459.27 E-value: 2.97e-149
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311584 160 PLESPVDLYILMDFSNSMSDDLDNLKKMGQNLARVLSQLTSDYTIGFGKFVDKVSVPQTDMRPEKLKEPWPNS----DPP 235
Cdd:pfam00362 1 AEDYPVDLYYLMDLSYSMKDDLDNLKKLGNDLAEEMRNITSNFRLGFGSFVDKPVMPYISTRPEKLKNPCPGEneqcDPP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311584 236 FSFKNVISLTEDVDEFRNKLQGERISGNLDAPEGGFDAILQTAVCTRDIGWRPDSTHLLVFSTESAFHYEADGAnvLAGI 315
Cdd:pfam00362 81 FGFRHVLSLTNDIEEFTEEVQKQRISGNLDAPEGGFDAIMQAAVCKDQIGWRNEARRLLVFSTDAGFHYAGDGK--LAGI 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311584 316 MSRNDERCHLDTTGTYTQYRTQDYPSVPTLVRLLAKHNIIPIFAVTNYSYSYYEKLHTYFPVSSLGVLQEDSSNIVELLE 395
Cdd:pfam00362 159 VTPNDGQCHLDSNGEYTKSTEQDYPSLGQLVRKLSENNINPIFAVTEEQYSLYEKLSKLIPGSSVGVLSEDSSNIVQLIK 238
|
250
....*....|
gi 2217311584 396 EAFNRIRSNL 405
Cdd:pfam00362 239 EAYEKIRSKV 248
|
|
| Integrin_B_tail |
pfam07965 |
Integrin beta tail domain; This is the beta tail domain of the Integrin protein. Integrins are ... |
661-744 |
2.06e-27 |
|
Integrin beta tail domain; This is the beta tail domain of the Integrin protein. Integrins are receptors which are involved in cell-cell and cell-extracellular matrix interactions.
Pssm-ID: 462325 Cd Length: 84 Bit Score: 106.98 E-value: 2.06e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311584 661 CEDLRSCVQCQAWGTGEKKGRTC-EECNFKVKMVDELKRAEE-VVVRCSFRDEdDDCTYSYTMEGDgaPGPNSTVLVHKK 738
Cdd:pfam07965 1 CEEKKSCVECQAFKTGPLKEKNCsRNCKFEIILVEVLKEDEEpGAVLCSFKDE-DDCWFTFTYYED--ESGKYVVHVQKE 77
|
....*.
gi 2217311584 739 KDCPPG 744
Cdd:pfam07965 78 RECPPG 83
|
|
| Calx-beta |
pfam03160 |
Calx-beta domain; |
1025-1119 |
3.62e-25 |
|
Calx-beta domain;
Pssm-ID: 397326 [Multi-domain] Cd Length: 91 Bit Score: 101.17 E-value: 3.62e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311584 1025 DVVSFEQPEFSVSRGDQVARIPVIRRVLD-GGKSQVSYRTQDGTAQGNRDYIPVEGELLFQPGEAWKELQVKLLElqevD 1103
Cdd:pfam03160 2 GVIGFEPPTYQVSENDGVAEVCVVRMSGTlRRTVVVPYRTEDGTATAGDDYEPVEGELVFGPGETEKCINVTIID----D 77
|
90
....*....|....*.
gi 2217311584 1104 SLLRGRqvRRFHVQLS 1119
Cdd:pfam03160 78 DVYEGD--ENFFVLLS 91
|
|
| Calx_beta |
smart00237 |
Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin ... |
1026-1119 |
2.89e-23 |
|
Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin subunit beta4 (and some cyanobacterial proteins)
Pssm-ID: 197594 [Multi-domain] Cd Length: 90 Bit Score: 95.40 E-value: 2.89e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311584 1026 VVSFEQPEFSVSRGDQVARIPVIRRVLDGGKSQVSYRTQDGTAQGNRDYIPVEGELLFQPGEAWKELQVKLLelqeVDSL 1105
Cdd:smart00237 3 SVGFEQPVYTVSESDGEVEVCVVRTGGARGPVVVPYSTEDGTATAGSDYEPVPGELTFPPGETEKEIRIKII----DDDI 78
|
90
....*....|....
gi 2217311584 1106 LRGrqVRRFHVQLS 1119
Cdd:smart00237 79 YEK--DETFYVRLS 90
|
|
| fn3 |
pfam00041 |
Fibronectin type III domain; |
1730-1815 |
2.86e-21 |
|
Fibronectin type III domain;
Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 89.78 E-value: 2.86e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311584 1730 SAPGPLVFTALSPDSLQLSWERPRRPNGDIVGYLVTCEMAQGGGPATAFRVDGDspESRLTVPGLSENVPYKFKVQARTT 1809
Cdd:pfam00041 1 SAPSNLTVTDVTSTSLTVSWTPPPDGNGPITGYEVEYRPKNSGEPWNEITVPGT--TTSVTLTGLKPGTEYEVRVQAVNG 78
|
....*.
gi 2217311584 1810 EGFGPE 1815
Cdd:pfam00041 79 GGEGPP 84
|
|
| fn3 |
pfam00041 |
Fibronectin type III domain; |
1617-1699 |
2.18e-19 |
|
Fibronectin type III domain;
Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 84.39 E-value: 2.18e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311584 1617 DTPTRLVFSALGPTSLRVSWQEPR-CERPLQGYSVEYQLLNGGE-LHRLNIPNPaQTSVVVEDLLPNHSYVFRVRAQSQE 1694
Cdd:pfam00041 1 SAPSNLTVTDVTSTSLTVSWTPPPdGNGPITGYEVEYRPKNSGEpWNEITVPGT-TTSVTLTGLKPGTEYEVRVQAVNGG 79
|
....*
gi 2217311584 1695 GWGRE 1699
Cdd:pfam00041 80 GEGPP 84
|
|
| FN3 |
cd00063 |
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
1616-1697 |
2.52e-19 |
|
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 84.47 E-value: 2.52e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311584 1616 PDTPTRLVFSALGPTSLRVSWQEPRCE-RPLQGYSVEYQLLNGGELHRLNIPNPAQTSVVVEDLLPNHSYVFRVRAQSQE 1694
Cdd:cd00063 1 PSPPTNLRVTDVTSTSVTLSWTPPEDDgGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGG 80
|
...
gi 2217311584 1695 GWG 1697
Cdd:cd00063 81 GES 83
|
|
| FN3 |
cd00063 |
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
1729-1814 |
4.79e-17 |
|
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 77.92 E-value: 4.79e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311584 1729 PSAPGPLVFTALSPDSLQLSWERPRRPNGDIVGYLVTCEMAQGGGPATAFRVDGDspESRLTVPGLSENVPYKFKVQART 1808
Cdd:cd00063 1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSGDWKEVEVTPGS--ETSYTLTGLKPGTEYEFRVRAVN 78
|
....*.
gi 2217311584 1809 TEGFGP 1814
Cdd:cd00063 79 GGGESP 84
|
|
| fn3 |
pfam00041 |
Fibronectin type III domain; |
1163-1243 |
6.98e-16 |
|
Fibronectin type III domain;
Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 74.37 E-value: 6.98e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311584 1163 GAPQNPNAKAAGSRKIHFNWLPP---SGKPMGYRVKYWIQGDSESEAHLLDSKVP-SVELTNLYPYCDYEMKVCAYGAQG 1238
Cdd:pfam00041 1 SAPSNLTVTDVTSTSLTVSWTPPpdgNGPITGYEVEYRPKNSGEPWNEITVPGTTtSVTLTGLKPGTEYEVRVQAVNGGG 80
|
....*
gi 2217311584 1239 EGPYS 1243
Cdd:pfam00041 81 EGPPS 85
|
|
| FN3 |
smart00060 |
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ... |
1616-1697 |
2.55e-15 |
|
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.
Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 72.65 E-value: 2.55e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311584 1616 PDTPTRLVFSALGPTSLRVSWQEPRcERPLQGYSVEYQLLNGGELHRLN--IPNPAQTSVVVEDLLPNHSYVFRVRAQSQ 1693
Cdd:smart00060 1 PSPPSNLRVTDVTSTSVTLSWEPPP-DDGITGYIVGYRVEYREEGSEWKevNVTPSSTSYTLTGLKPGTEYEFRVRAVNG 79
|
....
gi 2217311584 1694 EGWG 1697
Cdd:smart00060 80 AGEG 83
|
|
| FN3 |
smart00060 |
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ... |
1729-1813 |
1.31e-14 |
|
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.
Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 70.72 E-value: 1.31e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311584 1729 PSAPGPLVFTALSPDSLQLSWERPRRPNGDivGYLVTCEMAQGGGPATAFRVDGDSPESRLTVPGLSENVPYKFKVQART 1808
Cdd:smart00060 1 PSPPSNLRVTDVTSTSVTLSWEPPPDDGIT--GYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVN 78
|
....*
gi 2217311584 1809 TEGFG 1813
Cdd:smart00060 79 GAGEG 83
|
|
| fn3 |
pfam00041 |
Fibronectin type III domain; |
1256-1344 |
3.68e-14 |
|
Fibronectin type III domain;
Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 69.37 E-value: 3.68e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311584 1256 SEPGRLAFNVVSSTVTQLSWAEPAETNGEITAYEVCYGLVNDdnrpIGPMKKVLVDNPKNRMLLiENLRESQPYRYTVKA 1335
Cdd:pfam00041 1 SAPSNLTVTDVTSTSLTVSWTPPPDGNGPITGYEVEYRPKNS----GEPWNEITVPGTTTSVTL-TGLKPGTEYEVRVQA 75
|
....*....
gi 2217311584 1336 RNGAGWGPE 1344
Cdd:pfam00041 76 VNGGGEGPP 84
|
|
| FN3 |
cd00063 |
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
1255-1348 |
4.63e-14 |
|
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 69.45 E-value: 4.63e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311584 1255 PSEPGRLAFNVVSSTVTQLSWAEPAETNGEITAYEVCYGLVNDDNrpigpMKKVLVDNPKNRMLLIENLRESQPYRYTVK 1334
Cdd:cd00063 1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSGD-----WKEVEVTPGSETSYTLTGLKPGTEYEFRVR 75
|
90
....*....|....
gi 2217311584 1335 ARNGAGWGPEREAI 1348
Cdd:cd00063 76 AVNGGGESPPSESV 89
|
|
| FN3 |
COG3401 |
Fibronectin type 3 domain [General function prediction only]; |
1615-1834 |
5.94e-14 |
|
Fibronectin type 3 domain [General function prediction only];
Pssm-ID: 442628 [Multi-domain] Cd Length: 603 Bit Score: 76.96 E-value: 5.94e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311584 1615 VPDTPTRLVFSALGPTSLRVSWQEPRcERPLQGYSVEYQLLNGGELHRlnIPNPAQTSVVVEDLLPNHSYVFRVRAQSQE 1694
Cdd:COG3401 232 PPSAPTGLTATADTPGSVTLSWDPVT-ESDATGYRVYRSNSGDGPFTK--VATVTTTSYTDTGLTNGTTYYYRVTAVDAA 308
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311584 1695 GwgreregvitIESqvhPQSPlcplPGSAFT-LSTPSAPGPLVFTALSPDSLQLSWERPrrPNGDIVGYLVTcemaQGGG 1773
Cdd:COG3401 309 G----------NES---APSN----VVSVTTdLTPPAAPSGLTATAVGSSSITLSWTAS--SDADVTGYNVY----RSTS 365
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2217311584 1774 PATAFRVDGDSP-ESRLTVPGLSENVPYKFKVQARTTEGFGPEREGIITIESQDGGPFPQLG 1834
Cdd:COG3401 366 GGGTYTKIAETVtTTSYTDTGLTPGTTYYYKVTAVDAAGNESAPSEEVSATTASAASGESLT 427
|
|
| FN3 |
cd00063 |
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
1163-1250 |
3.44e-13 |
|
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 67.14 E-value: 3.44e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311584 1163 GAPQNPNAKAAGSRKIHFNWLPPS---GKPMGYRVKYWIQGDSE-SEAHLLDSKVPSVELTNLYPYCDYEMKVCAYGAQG 1238
Cdd:cd00063 2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDwKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81
|
90
....*....|..
gi 2217311584 1239 EGPYSSLVSCRT 1250
Cdd:cd00063 82 ESPPSESVTVTT 93
|
|
| PSI_integrin |
pfam17205 |
Integrin plexin domain; This short disulphide rich domain is found at the N-terminus of ... |
63-108 |
8.03e-11 |
|
Integrin plexin domain; This short disulphide rich domain is found at the N-terminus of integrin beta chains.
Pssm-ID: 465380 Cd Length: 47 Bit Score: 58.71 E-value: 8.03e-11
10 20 30 40
....*....|....*....|....*....|....*....|....*...
gi 2217311584 63 NRCKKApVKSCTECVRVDKDCAYCTDEMF--RDRRCNTQAELLAAGCQ 108
Cdd:pfam17205 1 NRCTSA-STSCEECIQSGPDCAWCTDENFtsGSPRCDTRENLLARGCS 47
|
|
| I-EGF_1 |
pfam18372 |
Integrin beta epidermal growth factor like domain 1; This is the I-EGF 1 domain found in ... |
492-520 |
1.76e-10 |
|
Integrin beta epidermal growth factor like domain 1; This is the I-EGF 1 domain found in several integrin betas such as integrin beta 1-7. Structural analysis reveal an epidermal growth factor-like (I-EGF) domains 1 and 2. EGF1 lacks one disulfide (C2-C4) relative to the integrin EGF 2, 3, and 4 domains, this allows the C-terminal end of EGF1 to flex remarkably relative to its N-terminal end.
Pssm-ID: 465729 Cd Length: 29 Bit Score: 57.11 E-value: 1.76e-10
10 20
....*....|....*....|....*....
gi 2217311584 492 CELQKEVRSARCSFNGDFVCGQCVCSEGW 520
Cdd:pfam18372 1 CEKQAEPNSPRCSGNGTFVCGVCVCNPGY 29
|
|
| FN3 |
COG3401 |
Fibronectin type 3 domain [General function prediction only]; |
1164-1340 |
1.98e-10 |
|
Fibronectin type 3 domain [General function prediction only];
Pssm-ID: 442628 [Multi-domain] Cd Length: 603 Bit Score: 65.79 E-value: 1.98e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311584 1164 APQNPNAKAAGSRKIHFNWLPPSGKP-MGYRVKYWIQGDSESEahlldsKVPSVELTNlypYCD--------YEMKVCAY 1234
Cdd:COG3401 235 APTGLTATADTPGSVTLSWDPVTESDaTGYRVYRSNSGDGPFT------KVATVTTTS---YTDtgltngttYYYRVTAV 305
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311584 1235 GAQG-EGPYSSLVSCRTHQEVPSEPGRLAFNVVSSTVTQLSWAEPaeTNGEITAYEVCYglvndDNRPIGPMKKVlVDNP 1313
Cdd:COG3401 306 DAAGnESAPSNVVSVTTDLTPPAAPSGLTATAVGSSSITLSWTAS--SDADVTGYNVYR-----STSGGGTYTKI-AETV 377
|
170 180
....*....|....*....|....*..
gi 2217311584 1314 KNRMLLIENLRESQPYRYTVKARNGAG 1340
Cdd:COG3401 378 TTTSYTDTGLTPGTTYYYKVTAVDAAG 404
|
|
| caca |
TIGR00845 |
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ... |
1027-1141 |
5.97e-10 |
|
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]
Pssm-ID: 273296 [Multi-domain] Cd Length: 928 Bit Score: 64.43 E-value: 5.97e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311584 1027 VSFEQPEFSVSRGDQVARIPVIRRVLDGGKS-QVSYRTQDGTAQGNRDYIPVEGELLFQPGEAWKELQVKLL--ELQEVD 1103
Cdd:TIGR00845 402 IFFEPGHYTCLENCGTVALTVVRRGGDLTNTvYVDYRTEDGTANAGSDYEFTEGTLVFKPGETQKEFRIGIIddDIFEED 481
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 2217311584 1104 sllrgrqvRRFHVQLSNPKFG--------------AHLGQPHSTTIIIRDPD 1141
Cdd:TIGR00845 482 --------EHFYVRLSNLRVGsedgileanhvsavAQLASPNTATVTILDDD 525
|
|
| FN3 |
smart00060 |
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ... |
1163-1240 |
2.15e-09 |
|
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.
Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 55.70 E-value: 2.15e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311584 1163 GAPQNPNAKAAGSRKIHFNWLPP-SGKPMGYRVKYWIQGDSESEA---HLLDSKVPSVELTNLYPYCDYEMKVCAYGAQG 1238
Cdd:smart00060 2 SPPSNLRVTDVTSTSVTLSWEPPpDDGITGYIVGYRVEYREEGSEwkeVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81
|
..
gi 2217311584 1239 EG 1240
Cdd:smart00060 82 EG 83
|
|
| FN3 |
smart00060 |
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ... |
1255-1342 |
2.86e-09 |
|
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.
Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 55.70 E-value: 2.86e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311584 1255 PSEPGRLAFNVVSSTVTQLSWAEPAETNGeiTAYEVCYGLVNddnRPIGPMKKVLVDNPKNRMLLIENLRESQPYRYTVK 1334
Cdd:smart00060 1 PSPPSNLRVTDVTSTSVTLSWEPPPDDGI--TGYIVGYRVEY---REEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVR 75
|
....*...
gi 2217311584 1335 ARNGAGWG 1342
Cdd:smart00060 76 AVNGAGEG 83
|
|
| FN3 |
COG3401 |
Fibronectin type 3 domain [General function prediction only]; |
1667-1811 |
3.67e-08 |
|
Fibronectin type 3 domain [General function prediction only];
Pssm-ID: 442628 [Multi-domain] Cd Length: 603 Bit Score: 58.48 E-value: 3.67e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311584 1667 NPAQTSVVVEDLLPNHSYVFRVRAQSQEGWGREREGVitiesqvhpqsplcplpgSAFTLST-PSAPGPLVFTALSPDSL 1745
Cdd:COG3401 188 TSTTLVDGGGDIEPGTTYYYRVAATDTGGESAPSNEV------------------SVTTPTTpPSAPTGLTATADTPGSV 249
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2217311584 1746 QLSWERPrrPNGDIVGYLVtcemAQGGGPATAFRVDGDSPESRLTVPGLSENVPYKFKVQARTTEG 1811
Cdd:COG3401 250 TLSWDPV--TESDATGYRV----YRSNSGDGPFTKVATVTTTSYTDTGLTNGTTYYYRVTAVDAAG 309
|
|
| FN3 |
COG3401 |
Fibronectin type 3 domain [General function prediction only]; |
1181-1340 |
2.15e-06 |
|
Fibronectin type 3 domain [General function prediction only];
Pssm-ID: 442628 [Multi-domain] Cd Length: 603 Bit Score: 52.70 E-value: 2.15e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311584 1181 NWLPPSGKPMGYRVKYWIQGDSESEAHLLDSKVPSVELTNLYPYCDYEMKVCAYGAQGEGPYSSLVSCRTHQEVPSEPGR 1260
Cdd:COG3401 159 TASSVAGAGVVVSPDTSATAAVATTSLTVTSTTLVDGGGDIEPGTTYYYRVAATDTGGESAPSNEVSVTTPTTPPSAPTG 238
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311584 1261 LAFNVVSSTVTQLSWAEPAETNgeITAYEVCYGLVNDdnrpiGPMKKvlVDNPKNRMLLIENLRESQPYRYTVKARNGAG 1340
Cdd:COG3401 239 LTATADTPGSVTLSWDPVTESD--ATGYRVYRSNSGD-----GPFTK--VATVTTTSYTDTGLTNGTTYYYRVTAVDAAG 309
|
|
| caca |
TIGR00845 |
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ... |
1013-1122 |
2.20e-06 |
|
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]
Pssm-ID: 273296 [Multi-domain] Cd Length: 928 Bit Score: 52.87 E-value: 2.20e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311584 1013 LVNITIIKEQARDVVSFEQPEFSVSRGDQVARIPVIRRVLDGGKSQVSYRTQDGTAQ-GNRDYIPVEGELLFQPGEAWKE 1091
Cdd:TIGR00845 516 TATVTILDDDHAGIFTFEEDVFHVSESIGIMEVKVLRTSGARGTVIVPYRTVEGTARgGGKDFEDTCGELEFENDETEKT 595
|
90 100 110
....*....|....*....|....*....|.
gi 2217311584 1092 LQVKLLELQEVDsllrgRQVrRFHVQLSNPK 1122
Cdd:TIGR00845 596 IRVKIVDDEEYE-----KND-TFFIELGEPR 620
|
|
| EGF_2 |
pfam07974 |
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins. |
585-608 |
1.16e-03 |
|
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
Pssm-ID: 400365 Cd Length: 26 Bit Score: 38.10 E-value: 1.16e-03
|
| |
