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Conserved domains on  [gi|2217263308|ref|XP_047295034|]
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AP-4 complex subunit beta-1 isoform X11 [Homo sapiens]

Protein Classification

adaptin family protein( domain architecture ID 13560656)

adaptin family protein is involved in the formation of clathrin-coated pits and vesicles, similar to human AP-4 complex subunit beta-1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
B2-adapt-app_C pfam09066
Beta2-adaptin appendage, C-terminal sub-domain; Members of this family adopt a structure ...
 296-406 2.80e-33

Beta2-adaptin appendage, C-terminal sub-domain; Members of this family adopt a structure consisting of a 5 stranded beta-sheet, flanked by one alpha helix on the outer side, and by two alpha helices on the inner side. This domain is required for binding to clathrin, and its subsequent polymerization. Furthermore, a hydrophobic patch present in the domain also binds to a subset of D-phi-F/W motif-containing proteins that are bound by the alpha-adaptin appendage domain (epsin, AP180, eps15).


:

Pssm-ID: 462667  Cd Length: 111  Bit Score: 120.83  E-value: 2.80e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217263308 296 VPNRQLTADYFEKTWLSLKVAHQQVLPWRGE--FHPDTLQMALQVVNIQTIAMSRAGSRPWKAYLSAQDDTGCLFLTELL 373
Cdd:pfam09066   1 VEDGKLDREVFLETWKSLPDSNELSLTLQNLasVSPDAIEQKLQANNIFTIAKRGVEGPQEKLYFSAKLTNGILFLVELT 80

                          90       100       110
                  ....*....|....*....|....*....|...
gi 2217263308 374 LEPGNSEMQISVKQNEarTETLNSFISVLETVI 406
Cdd:pfam09066  81 INTPGSNVKLSVKSED--PEVAPLFLQLFESIL 111
Adaptin_N super family cl37648
Adaptin N terminal region; This family consists of the N terminal region of various alpha, ...
 55-200 3.14e-10

Adaptin N terminal region; This family consists of the N terminal region of various alpha, beta and gamma subunits of the AP-1, AP-2 and AP-3 adaptor protein complexes. The adaptor protein (AP) complexes are involved in the formation of clathrin-coated pits and vesicles. The N-terminal region of the various adaptor proteins (APs) is constant by comparison to the C-terminal which is variable within members of the AP-2 family; and it has been proposed that this constant region interacts with another uniform component of the coated vesicles.


The actual alignment was detected with superfamily member pfam01602:

Pssm-ID: 396262 [Multi-domain]  Cd Length: 523  Bit Score: 61.87  E-value: 3.14e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217263308  55 DQCVQILTELLGLRQEHITTVVVQTFRDLVWLCPQCTEAVCQALpgCE--ENIQDSEGKQALIWLLGVHGERIPN---AP 129
Cdd:pfam01602 373 EWYLDVLLDLLSLAGSYVVDEIVEVIRDIIQNVPELREYILEHL--CEllEDIESPEALAAALWILGEYGELIPNgssPP 450

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2217263308 130 YVLEDFVENVKSETfPAVKMELLTALL--RLFLSRPAECQDMLGRLLYYCIEEEKDMAVRDRGLFYYRLLLVG 200
Cdd:pfam01602 451 DLLRSILEVFVLES-AKVRAAALTALAklGLTSPEETTQNLIIQLLLTLATQDSLDLEVRDRAVEYLRLLSLA 522
 
Name Accession Description Interval E-value
B2-adapt-app_C pfam09066
Beta2-adaptin appendage, C-terminal sub-domain; Members of this family adopt a structure ...
 296-406 2.80e-33

Beta2-adaptin appendage, C-terminal sub-domain; Members of this family adopt a structure consisting of a 5 stranded beta-sheet, flanked by one alpha helix on the outer side, and by two alpha helices on the inner side. This domain is required for binding to clathrin, and its subsequent polymerization. Furthermore, a hydrophobic patch present in the domain also binds to a subset of D-phi-F/W motif-containing proteins that are bound by the alpha-adaptin appendage domain (epsin, AP180, eps15).


Pssm-ID: 462667  Cd Length: 111  Bit Score: 120.83  E-value: 2.80e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217263308 296 VPNRQLTADYFEKTWLSLKVAHQQVLPWRGE--FHPDTLQMALQVVNIQTIAMSRAGSRPWKAYLSAQDDTGCLFLTELL 373
Cdd:pfam09066   1 VEDGKLDREVFLETWKSLPDSNELSLTLQNLasVSPDAIEQKLQANNIFTIAKRGVEGPQEKLYFSAKLTNGILFLVELT 80

                          90       100       110
                  ....*....|....*....|....*....|...
gi 2217263308 374 LEPGNSEMQISVKQNEarTETLNSFISVLETVI 406
Cdd:pfam09066  81 INTPGSNVKLSVKSED--PEVAPLFLQLFESIL 111
B2-adapt-app_C smart01020
Beta2-adaptin appendage, C-terminal sub-domain; Members of this family adopt a structure ...
 295-407 3.49e-31

Beta2-adaptin appendage, C-terminal sub-domain; Members of this family adopt a structure consisting of a 5 stranded beta-sheet, flanked by one alpha helix on the outer side, and by two alpha helices on the inner side. This domain is required for binding to clathrin, and its subsequent polymerisation. Furthermore, a hydrophobic patch present in the domain also binds to a subset of D-phi-F/W motif-containing proteins that are bound by the alpha-adaptin appendage domain (epsin, AP180, eps15).


Pssm-ID: 198088  Cd Length: 111  Bit Score: 115.10  E-value: 3.49e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217263308  295 LVPNRQLTADYFEKTWLSLKVAHQQVLPWRGE-FHPDTLQMALQVVNIQTIAMSRAGSRpWKAYLSAQDDTGCLFLTELL 373
Cdd:smart01020   1 FVEDGQMEREVFLKTWKSLPESNEQQFQLQPNnLNPDTIIKKLQSNNIFTIAKRNVGNQ-DKLYLSAKLTNGIWILIELT 79

                           90       100       110
                   ....*....|....*....|....*....|....
gi 2217263308  374 LEPGNSEMQISVKQNEarTETLNSFISVLETVIG 407
Cdd:smart01020  80 INPGTPNVTLSVKCDS--PEVIQLFTQVFEKILS 111
Adaptin_N pfam01602
Adaptin N terminal region; This family consists of the N terminal region of various alpha, ...
 55-200 3.14e-10

Adaptin N terminal region; This family consists of the N terminal region of various alpha, beta and gamma subunits of the AP-1, AP-2 and AP-3 adaptor protein complexes. The adaptor protein (AP) complexes are involved in the formation of clathrin-coated pits and vesicles. The N-terminal region of the various adaptor proteins (APs) is constant by comparison to the C-terminal which is variable within members of the AP-2 family; and it has been proposed that this constant region interacts with another uniform component of the coated vesicles.


Pssm-ID: 396262 [Multi-domain]  Cd Length: 523  Bit Score: 61.87  E-value: 3.14e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217263308  55 DQCVQILTELLGLRQEHITTVVVQTFRDLVWLCPQCTEAVCQALpgCE--ENIQDSEGKQALIWLLGVHGERIPN---AP 129
Cdd:pfam01602 373 EWYLDVLLDLLSLAGSYVVDEIVEVIRDIIQNVPELREYILEHL--CEllEDIESPEALAAALWILGEYGELIPNgssPP 450

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2217263308 130 YVLEDFVENVKSETfPAVKMELLTALL--RLFLSRPAECQDMLGRLLYYCIEEEKDMAVRDRGLFYYRLLLVG 200
Cdd:pfam01602 451 DLLRSILEVFVLES-AKVRAAALTALAklGLTSPEETTQNLIIQLLLTLATQDSLDLEVRDRAVEYLRLLSLA 522
PTZ00429 PTZ00429
beta-adaptin; Provisional
 57-208 6.57e-05

beta-adaptin; Provisional


Pssm-ID: 240415 [Multi-domain]  Cd Length: 746  Bit Score: 45.31  E-value: 6.57e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217263308  57 CVQILTELLGLRQEHITTVV------VQTFRDLVWLCPQCTEavCQAlpgceENIQDSEGKQALIWLLGVHGERIPNAPY 130
Cdd:PTZ00429  406 CANLLLQIVDRRPELLPQVVtaakdiVRKYPELLMLDTLVTD--YGA-----DEVVEEEAKVSLLWMLGEYCDFIENGKD 478

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217263308 131 VLEDFVENVKSETfPAVKMELLTALLRLFLSRPAECQDMLGRLLYYCIEEEKDMAVRDRGLFYYRLLL--VGIDEVKRIL 208
Cdd:PTZ00429  479 IIQRFIDTIMEHE-QRVQLAILSAAVKMFLRDPQGMEPQLNRVLETVTTHSDDPDVRDRAFAYWRLLSkgITVAQMKKVV 557
COG5096 COG5096
Vesicle coat complex, various subunits [Intracellular trafficking, secretion, and vesicular ...
 115-212 2.65e-03

Vesicle coat complex, various subunits [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 227427 [Multi-domain]  Cd Length: 757  Bit Score: 40.10  E-value: 2.65e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217263308 115 IWLLGVHGERIPN-APYVLEDFVENVKSETfPAVKMELLTALLRLFLSRP---AECQDMLGR-LLYYCIEEEKDMAVRDR 189
Cdd:COG5096   474 AWLLGEFSDIIPRlEPELLRIAISNFVDET-LEVQYTILMSSVKLIANSIrkaKQCNSELDQdVLRRCFDYVLVPDLRDR 552

                          90       100
                  ....*....|....*....|....
gi 2217263308 190 GLFYYRLLLVGIDE-VKRILCSPK 212
Cdd:COG5096   553 ARMYSRLLSTPLPEfSDPILCEAK 576
 
Name Accession Description Interval E-value
B2-adapt-app_C pfam09066
Beta2-adaptin appendage, C-terminal sub-domain; Members of this family adopt a structure ...
 296-406 2.80e-33

Beta2-adaptin appendage, C-terminal sub-domain; Members of this family adopt a structure consisting of a 5 stranded beta-sheet, flanked by one alpha helix on the outer side, and by two alpha helices on the inner side. This domain is required for binding to clathrin, and its subsequent polymerization. Furthermore, a hydrophobic patch present in the domain also binds to a subset of D-phi-F/W motif-containing proteins that are bound by the alpha-adaptin appendage domain (epsin, AP180, eps15).


Pssm-ID: 462667  Cd Length: 111  Bit Score: 120.83  E-value: 2.80e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217263308 296 VPNRQLTADYFEKTWLSLKVAHQQVLPWRGE--FHPDTLQMALQVVNIQTIAMSRAGSRPWKAYLSAQDDTGCLFLTELL 373
Cdd:pfam09066   1 VEDGKLDREVFLETWKSLPDSNELSLTLQNLasVSPDAIEQKLQANNIFTIAKRGVEGPQEKLYFSAKLTNGILFLVELT 80

                          90       100       110
                  ....*....|....*....|....*....|...
gi 2217263308 374 LEPGNSEMQISVKQNEarTETLNSFISVLETVI 406
Cdd:pfam09066  81 INTPGSNVKLSVKSED--PEVAPLFLQLFESIL 111
B2-adapt-app_C smart01020
Beta2-adaptin appendage, C-terminal sub-domain; Members of this family adopt a structure ...
 295-407 3.49e-31

Beta2-adaptin appendage, C-terminal sub-domain; Members of this family adopt a structure consisting of a 5 stranded beta-sheet, flanked by one alpha helix on the outer side, and by two alpha helices on the inner side. This domain is required for binding to clathrin, and its subsequent polymerisation. Furthermore, a hydrophobic patch present in the domain also binds to a subset of D-phi-F/W motif-containing proteins that are bound by the alpha-adaptin appendage domain (epsin, AP180, eps15).


Pssm-ID: 198088  Cd Length: 111  Bit Score: 115.10  E-value: 3.49e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217263308  295 LVPNRQLTADYFEKTWLSLKVAHQQVLPWRGE-FHPDTLQMALQVVNIQTIAMSRAGSRpWKAYLSAQDDTGCLFLTELL 373
Cdd:smart01020   1 FVEDGQMEREVFLKTWKSLPESNEQQFQLQPNnLNPDTIIKKLQSNNIFTIAKRNVGNQ-DKLYLSAKLTNGIWILIELT 79

                           90       100       110
                   ....*....|....*....|....*....|....
gi 2217263308  374 LEPGNSEMQISVKQNEarTETLNSFISVLETVIG 407
Cdd:smart01020  80 INPGTPNVTLSVKCDS--PEVIQLFTQVFEKILS 111
Adaptin_N pfam01602
Adaptin N terminal region; This family consists of the N terminal region of various alpha, ...
 55-200 3.14e-10

Adaptin N terminal region; This family consists of the N terminal region of various alpha, beta and gamma subunits of the AP-1, AP-2 and AP-3 adaptor protein complexes. The adaptor protein (AP) complexes are involved in the formation of clathrin-coated pits and vesicles. The N-terminal region of the various adaptor proteins (APs) is constant by comparison to the C-terminal which is variable within members of the AP-2 family; and it has been proposed that this constant region interacts with another uniform component of the coated vesicles.


Pssm-ID: 396262 [Multi-domain]  Cd Length: 523  Bit Score: 61.87  E-value: 3.14e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217263308  55 DQCVQILTELLGLRQEHITTVVVQTFRDLVWLCPQCTEAVCQALpgCE--ENIQDSEGKQALIWLLGVHGERIPN---AP 129
Cdd:pfam01602 373 EWYLDVLLDLLSLAGSYVVDEIVEVIRDIIQNVPELREYILEHL--CEllEDIESPEALAAALWILGEYGELIPNgssPP 450

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2217263308 130 YVLEDFVENVKSETfPAVKMELLTALL--RLFLSRPAECQDMLGRLLYYCIEEEKDMAVRDRGLFYYRLLLVG 200
Cdd:pfam01602 451 DLLRSILEVFVLES-AKVRAAALTALAklGLTSPEETTQNLIIQLLLTLATQDSLDLEVRDRAVEYLRLLSLA 522
PTZ00429 PTZ00429
beta-adaptin; Provisional
 57-208 6.57e-05

beta-adaptin; Provisional


Pssm-ID: 240415 [Multi-domain]  Cd Length: 746  Bit Score: 45.31  E-value: 6.57e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217263308  57 CVQILTELLGLRQEHITTVV------VQTFRDLVWLCPQCTEavCQAlpgceENIQDSEGKQALIWLLGVHGERIPNAPY 130
Cdd:PTZ00429  406 CANLLLQIVDRRPELLPQVVtaakdiVRKYPELLMLDTLVTD--YGA-----DEVVEEEAKVSLLWMLGEYCDFIENGKD 478

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217263308 131 VLEDFVENVKSETfPAVKMELLTALLRLFLSRPAECQDMLGRLLYYCIEEEKDMAVRDRGLFYYRLLL--VGIDEVKRIL 208
Cdd:PTZ00429  479 IIQRFIDTIMEHE-QRVQLAILSAAVKMFLRDPQGMEPQLNRVLETVTTHSDDPDVRDRAFAYWRLLSkgITVAQMKKVV 557
COG5096 COG5096
Vesicle coat complex, various subunits [Intracellular trafficking, secretion, and vesicular ...
 115-212 2.65e-03

Vesicle coat complex, various subunits [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 227427 [Multi-domain]  Cd Length: 757  Bit Score: 40.10  E-value: 2.65e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217263308 115 IWLLGVHGERIPN-APYVLEDFVENVKSETfPAVKMELLTALLRLFLSRP---AECQDMLGR-LLYYCIEEEKDMAVRDR 189
Cdd:COG5096   474 AWLLGEFSDIIPRlEPELLRIAISNFVDET-LEVQYTILMSSVKLIANSIrkaKQCNSELDQdVLRRCFDYVLVPDLRDR 552

                          90       100
                  ....*....|....*....|....
gi 2217263308 190 GLFYYRLLLVGIDE-VKRILCSPK 212
Cdd:COG5096   553 ARMYSRLLSTPLPEfSDPILCEAK 576
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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