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Conserved domains on  [gi|2217336293|ref|XP_047296482|]
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Z-DNA-binding protein 1 isoform X3 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
z-alpha super family cl02659
Adenosine deaminase z-alpha domain; This family consists of the N-terminus and thus the ...
 35-78 5.82e-05

Adenosine deaminase z-alpha domain; This family consists of the N-terminus and thus the z-alpha domain of double-stranded RNA-specific adenosine deaminase (ADAR), an RNA- editing enzyme. The z-alpha domain is a Z-DNA binding domain, and binding of this region to B-DNA has been shown to be disfavoured by steric hindrance.


The actual alignment was detected with superfamily member smart00550:

Pssm-ID: 295419  Cd Length: 68  Bit Score: 40.40  E-value: 5.82e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 2217336293   35 EEDIYRFLKDNGPQ--RALVIAQALGMRTaKDVNRDLYRMKSRHLL 78
Cdd:smart00550   8 EEKILEFLENSGDEtsTALQLAKNLGLPK-KEVNRVLYSLEKKGKV 52
 
Name Accession Description Interval E-value
Zalpha smart00550
Z-DNA-binding domain in adenosine deaminases; Helix-turn-helix-containing domain. Also known ...
 35-78 5.82e-05

Z-DNA-binding domain in adenosine deaminases; Helix-turn-helix-containing domain. Also known as Zab.


Pssm-ID: 128823  Cd Length: 68  Bit Score: 40.40  E-value: 5.82e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 2217336293   35 EEDIYRFLKDNGPQ--RALVIAQALGMRTaKDVNRDLYRMKSRHLL 78
Cdd:smart00550   8 EEKILEFLENSGDEtsTALQLAKNLGLPK-KEVNRVLYSLEKKGKV 52
 
Name Accession Description Interval E-value
Zalpha smart00550
Z-DNA-binding domain in adenosine deaminases; Helix-turn-helix-containing domain. Also known ...
 35-78 5.82e-05

Z-DNA-binding domain in adenosine deaminases; Helix-turn-helix-containing domain. Also known as Zab.


Pssm-ID: 128823  Cd Length: 68  Bit Score: 40.40  E-value: 5.82e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 2217336293   35 EEDIYRFLKDNGPQ--RALVIAQALGMRTaKDVNRDLYRMKSRHLL 78
Cdd:smart00550   8 EEKILEFLENSGDEtsTALQLAKNLGLPK-KEVNRVLYSLEKKGKV 52
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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