|
Name |
Accession |
Description |
Interval |
E-value |
| HECTc |
cd00078 |
HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It ... |
4060-4413 |
4.22e-161 |
|
HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ubiquitin molecules to the end of growing ubiquitin chains.
:
Pssm-ID: 238033 [Multi-domain] Cd Length: 352 Bit Score: 502.48 E-value: 4.22e-161
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217390770 4060 VHVRRDHVFEDSYRELHRKSPEEMKNRLYIVFEGEEGQDAGGLLREWYMIISREMFNPMYALFRTSPGDRVTYTINPSSH 4139
Cdd:cd00078 3 ITVRRDRILEDALRQLSKVSSSDLKKVLEVEFVGEEGIDAGGVTREFFTLVSKELFNPSYGLFRYTPDDSGLLYPNPSSF 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217390770 4140 CNPNHLSYFKFVGRIVAKAVYDNRLLECYFTRSFYKHILGKSVRYTDMESEDYHFYQGLVYLLENDVSTLGYDLTFSTEV 4219
Cdd:cd00078 83 ADEDHLKLFRFLGRLLGKALYEGRLLDLPFSRAFYKKLLGKPLSLEDLEELDPELYKSLKELLDNDGDEDDLELTFTIEL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217390770 4220 QE-FGVCEVRDLKPNGANILVTEENKKEYVHLVCQMRMTGAIRKQLAAFLEGFYEIIPKRLISIFTEQELELLISGLPTI 4298
Cdd:cd00078 163 DSsFGGAVTVELKPGGRDIPVTNENKEEYVDLYVDYRLNKGIEEQVEAFRDGFSEVIPEELLSLFTPEELELLICGSEDI 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217390770 4299 DIDDLKSNTEY-HKYQSNSIQIQWFWRALRSFDQADRAKFLQFVTGTSKVPLQGFAALEgmngiQKFQIHRDDRSTDRLP 4377
Cdd:cd00078 243 DLEDLKKNTEYkGGYSSDSPTIQWFWEVLESFTNEERKKFLQFVTGSSRLPVGGFADLN-----PKFTIRRVGSPDDRLP 317
|
330 340 350
....*....|....*....|....*....|....*.
gi 2217390770 4378 SAHTCFNQLDLPAYESFEKLRHMLLLAIQECsEGFG 4413
Cdd:cd00078 318 TAHTCFNLLKLPPYSSKEILREKLLYAINEG-AGFG 352
|
|
| DUF913 |
pfam06025 |
Domain of Unknown Function (DUF913); Members of this family are found in various ubiquitin ... |
438-904 |
1.18e-95 |
|
Domain of Unknown Function (DUF913); Members of this family are found in various ubiquitin protein ligases.
:
Pssm-ID: 461803 Cd Length: 369 Bit Score: 315.32 E-value: 1.18e-95
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217390770 438 RAVRVVD-LITNLD--MAAFQSHSGLSIFIYRLEHEVDLCRKECpfvikpkiqrpnttQEGEEMETDMdvadvamessPG 514
Cdd:pfam06025 1 RAVQFLDtLIYNFQdaFQAFRNAGGLDAIIDRIVHEVDSALELA--------------EAGKGTPSEY----------KS 56
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217390770 515 SSISMEhrldvelrasgsssstnissgpspgpspgpgtgpgpgpgpgpgpgpgpgpgpgpgpgpgpgpgprpgvqcIP-Q 593
Cdd:pfam06025 57 SVVDYE----------------------------------------------------------------------IPyY 66
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217390770 594 RAALLKSMLNFLKKAIQ--DPAFSDGIRHVMDGS-LPTSLKHIISNAEYYGPSLFLLATEVVTVFVFQEPSLLSSLQDNG 670
Cdd:pfam06025 67 RQQLLKWLLKFIHHMMQhsGGGTDRLLRNLIDSSqLLGSLRKIIENAKVFGSSVWSLAVNILSDFIHNEPTSFAVIQEAG 146
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217390770 671 LTDVMLHALLIKDVPATREVLGSLPNVFSALCLNARGLQSFVQCQPFERLFKVLLSPDYLPAMRrrrssdPLGDTASNLG 750
Cdd:pfam06025 147 LSKAFLEAVLAKGILPSSEAINSIPNAFGAICLNNAGLELFKSSNALESFFEIFESPDHVKAME------TDGELASNLG 220
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217390770 751 SAVDELMRHQPTLKTDATTAIIKLLEEICNLGRDP--------KYICQKPSIQKADGTATAPPPRSNHAAEEASSEDEEE 822
Cdd:pfam06025 221 SSFDELVRHHPSLKPAIINAVIDMLARVVELGSTKaepdgwgaKLWVGCSSSSSFSPASSGSLPMETDGESGDESSSDED 300
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217390770 823 EEVQAMQSFNSTQQNETEPNQQvvgteeripiPLMDYILNVMKFVESILSNNTtddHCQEFVNQKGLLPLVTILGLPNLP 902
Cdd:pfam06025 301 VEMEDAPDTDSTEETEPESHGN----------SLTDYIDNVARFLEAFFSNNS---HCSDFIEKGGIELLLDLATLPSLP 367
|
..
gi 2217390770 903 ID 904
Cdd:pfam06025 368 YD 369
|
|
| DUF908 super family |
cl20318 |
Domain of Unknown Function (DUF908); |
92-374 |
4.86e-23 |
|
Domain of Unknown Function (DUF908);
The actual alignment was detected with superfamily member pfam06012:
Pssm-ID: 428721 Cd Length: 351 Bit Score: 103.95 E-value: 4.86e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217390770 92 LLLAVLNFTALLIEYSFSRHLYSSIEHLTTLLASSDMQVVLAVLNLLYVFSKR-SNYITRLGSDKRTP-----------L 159
Cdd:pfam06012 5 LVEAILRFTRLLLENCGNRSIYNSSEHLNDLLNTTSLDVLLAALRLLLRLAQRySASNSRRGSAPRHIqqsllanhyniD 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217390770 160 LTRLQHLAESWG------------------GKENGFGLAECCRDLHmmKYPPS-ATTLHFEFYADPGAEVKIEK------ 214
Cdd:pfam06012 85 LDRLLKLAQPFPkppppdstdpapsttknsANEYANDLVSLAKEDS--KVLPSeWGSVKFTYYPSSSSDEAPTSskssts 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217390770 215 -----------------------------------RTTSNTLHYIHIEQLDKISESPSEIMESLtkMYSIPKDKQMLLFT 259
Cdd:pfam06012 163 snsspstptplrrsstlgtspdspsspststpssaADSDEGLRTFEIPESKVASKSLEDILAKA--IEDLPKESRFELLH 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217390770 260 HIRLAHGFSNHR--KRLQAVQARLHAISILVFVSPFAVYSNALQESANSILYnglieELVDVLQITDKQLMEIKAASLRT 337
Cdd:pfam06012 241 RIRIAKALNSSSeeSRQQLLAIRLLAIANLAYIHPESTFQTKLFEYDPDLVY-----QLAELIHPDTEVPLELQTAALYA 315
|
330 340 350
....*....|....*....|....*....|....*..
gi 2217390770 338 LTSIVHleRTPKLSSIIDCTGTASYHGFLPVLVRNCI 374
Cdd:pfam06012 316 LEALAR--HRAKLSDVLSALGANVNHGILLYVLRKAV 350
|
|
| UBA_HUWE1 |
cd14288 |
UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins; HUWE1, ... |
1407-1446 |
5.66e-15 |
|
UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins; HUWE1, also called ARF-binding protein 1 (ARF-BP1), HECT, UBA and WWE domain-containing protein 1, homologous to E6AP carboxyl terminus homologs protein 9 (HectH9), large structure of UREB1 (LASU1), Mcl-1 ubiquitin ligase E3 (Mule), upstream regulatory element-binding protein 1 (URE-B1), or URE-binding protein 1, may function as a ubiquitin-protein ligase that involves in the ubiquitination cascade that targets specific substrate proteins in proteolysis. It can ubiquitylate DNA polymerase beta (Pol beta), the major BER DNA polymerase and modulates base excision repair (BER). HUWE1 also acts as a critical mediator of both the p53-independent and p53-dependent tumor suppressor functions of ARF tumor suppressor in p53 regulation. Moreover, HUWE1 is both required and sufficient for the polyubiquitination of Mcl-1, an anti-apoptotic Bcl-2 family member involving in DNA damage-induced apoptosis. Furthermore, HUWE1 plays an important role in the regulation of Cdc6 stability after DNA damage. In addition, HUWE1 works as a partner of N-Myc oncoprotein in neural cells. It ubiquitinates N-Myc and primes it for proteasomal-mediated degradation. HUWE1 contains a ubiquitin-associated (UBA) domain, a WWE domain, and a Bcl-2 homology region 3 (BH3) domain at the N-terminus and a HECT domain at the C-terminus. WWE domain plays a role in the regulation of specific protein-protein interactions in a ubiquitin conjugation system. BH3 domain is responsible for the specific binding to Mcl-1. HECT domain involves in the inhibition of the transcriptional activity of p53 via a ubiquitin-dependent degradation pathway. It also controls neural differentiation and proliferation by destabilizing the N-Myc oncoprotein.
:
Pssm-ID: 270474 Cd Length: 40 Bit Score: 71.28 E-value: 5.66e-15
10 20 30 40
....*....|....*....|....*....|....*....|
gi 2217390770 1407 VNQQQLQQLMDMGFTREHAMEALLNTSTMEQATEYLLTHP 1446
Cdd:cd14288 1 VNEAHLQQLMDMGFTREHALEALLHTSTLEQATEYLLTHP 40
|
|
| WWE |
pfam02825 |
WWE domain; The WWE domain is named after three of its conserved residues and is predicted to ... |
1707-1768 |
4.50e-14 |
|
WWE domain; The WWE domain is named after three of its conserved residues and is predicted to mediate specific protein- protein interactions in ubiquitin and ADP ribose conjugation systems.
:
Pssm-ID: 460715 [Multi-domain] Cd Length: 66 Bit Score: 69.63 E-value: 4.50e-14
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2217390770 1707 WRWFDDRsGRWCSYSASNNSTIDSAWKSGETSV--RFTAGRRRYTVQFTTMVQVNEETGNRRPV 1768
Cdd:pfam02825 2 WEWEDDN-GGWHPYDPEVSSLIEEAYQKGKPSVdlSITTAGFPYTIDFKSMTQTNKDTGTTRPV 64
|
|
| UBM |
pfam14377 |
Ubiquitin binding region; This family contains repetitive element (RE) from a subgroup of HECT ... |
3066-3099 |
9.97e-08 |
|
Ubiquitin binding region; This family contains repetitive element (RE) from a subgroup of HECT E3 ubiquitin ligases and the Y-family translesion polymerases, including human HUWE1 and Arabidopsis UPL1. Each of these repetitive elements are approximately 20 amino acids in length and contain two predicted helical segments separated by a Leu-Pro motif. The REs from the Y-family polymerases were shown to bind ubiquitin and were the basis for a novel ubiquitin-binding domain called the ubiquitin-binding motif (UBM).
:
Pssm-ID: 464159 [Multi-domain] Cd Length: 34 Bit Score: 50.58 E-value: 9.97e-08
10 20 30
....*....|....*....|....*....|....
gi 2217390770 3066 GNPGVTEVSPEFLAALPPAIQEEVLAQQRAEQQR 3099
Cdd:pfam14377 1 AAPPPEGIDPSFLAALPPDLRQEVLAQQDDERLR 34
|
|
| PHA03247 super family |
cl33720 |
large tegument protein UL36; Provisional |
2791-3122 |
1.77e-06 |
|
large tegument protein UL36; Provisional
The actual alignment was detected with superfamily member PHA03247:
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 54.94 E-value: 1.77e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217390770 2791 SDGTPMPDSYPTTPSSTDAAtSESKETLGTLQSSQQQPTLPTPPALGEVPQELQSPAGeggSSTQLLMPVEPEELGPTRP 2870
Cdd:PHA03247 2637 EPDPHPPPTVPPPERPRDDP-APGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTVG---SLTSLADPPPPPPTPEPAP 2712
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217390770 2871 SGEAETTQMELSPAPTITSLSPERAEDSDALTAVSSQLEGSPMDTSSLASctleeavgdTSAAGSSEQPRAgsstPGDAP 2950
Cdd:PHA03247 2713 HALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPT---------TAGPPAPAPPAA----PAAGP 2779
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217390770 2951 PAVAEVQGRSDGSGESAQPPEDSSPPASSESSSTRDSAVAISGADSRGileEPLPSTSSEEEDPLAGISLPEGVDPSFLA 3030
Cdd:PHA03247 2780 PRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGP---LPPPTSAQPTAPPPPPGPPPPSLPLGGSV 2856
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217390770 3031 ALPDDIRREVLQNQLGIRPPTRTAPSTNS-SAPAVVGNPGVTEVSPEFLAALP-PAIQEEVLAQQRAEQQRRE---LAQN 3105
Cdd:PHA03247 2857 APGGDVRRRPPSRSPAAKPAAPARPPVRRlARPAVSRSTESFALPPDQPERPPqPQAPPPPQPQPQPPPPPQPqppPPPP 2936
|
330
....*....|....*..
gi 2217390770 3106 ASSDTPMDPVTFIQTLP 3122
Cdd:PHA03247 2937 PRPQPPLAPTTDPAGAG 2953
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| HECTc |
cd00078 |
HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It ... |
4060-4413 |
4.22e-161 |
|
HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ubiquitin molecules to the end of growing ubiquitin chains.
Pssm-ID: 238033 [Multi-domain] Cd Length: 352 Bit Score: 502.48 E-value: 4.22e-161
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217390770 4060 VHVRRDHVFEDSYRELHRKSPEEMKNRLYIVFEGEEGQDAGGLLREWYMIISREMFNPMYALFRTSPGDRVTYTINPSSH 4139
Cdd:cd00078 3 ITVRRDRILEDALRQLSKVSSSDLKKVLEVEFVGEEGIDAGGVTREFFTLVSKELFNPSYGLFRYTPDDSGLLYPNPSSF 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217390770 4140 CNPNHLSYFKFVGRIVAKAVYDNRLLECYFTRSFYKHILGKSVRYTDMESEDYHFYQGLVYLLENDVSTLGYDLTFSTEV 4219
Cdd:cd00078 83 ADEDHLKLFRFLGRLLGKALYEGRLLDLPFSRAFYKKLLGKPLSLEDLEELDPELYKSLKELLDNDGDEDDLELTFTIEL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217390770 4220 QE-FGVCEVRDLKPNGANILVTEENKKEYVHLVCQMRMTGAIRKQLAAFLEGFYEIIPKRLISIFTEQELELLISGLPTI 4298
Cdd:cd00078 163 DSsFGGAVTVELKPGGRDIPVTNENKEEYVDLYVDYRLNKGIEEQVEAFRDGFSEVIPEELLSLFTPEELELLICGSEDI 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217390770 4299 DIDDLKSNTEY-HKYQSNSIQIQWFWRALRSFDQADRAKFLQFVTGTSKVPLQGFAALEgmngiQKFQIHRDDRSTDRLP 4377
Cdd:cd00078 243 DLEDLKKNTEYkGGYSSDSPTIQWFWEVLESFTNEERKKFLQFVTGSSRLPVGGFADLN-----PKFTIRRVGSPDDRLP 317
|
330 340 350
....*....|....*....|....*....|....*.
gi 2217390770 4378 SAHTCFNQLDLPAYESFEKLRHMLLLAIQECsEGFG 4413
Cdd:cd00078 318 TAHTCFNLLKLPPYSSKEILREKLLYAINEG-AGFG 352
|
|
| HECTc |
smart00119 |
Domain Homologous to E6-AP Carboxyl Terminus with; E3 ubiquitin-protein ligases. Can bind to ... |
4084-4412 |
3.70e-159 |
|
Domain Homologous to E6-AP Carboxyl Terminus with; E3 ubiquitin-protein ligases. Can bind to E2 enzymes.
Pssm-ID: 214523 Cd Length: 328 Bit Score: 495.99 E-value: 3.70e-159
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217390770 4084 KNRLYIVFEGEEGQDAGGLLREWYMIISREMFNPMYALFRTSPGDRVTYTINPSSHCNPNHLSYFKFVGRIVAKAVYDNR 4163
Cdd:smart00119 4 KRVLEIEFEGEEGLDGGGVTREFFFLLSKELFNPDYGLFRYSPNDYLLYPNPRSGFANEEHLSYFRFIGRVLGKALYDNR 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217390770 4164 LLECYFTRSFYKHILGKSVRYTDMESEDYHFYQGLVYL-LENDVSTLgYDLTFSTEVQE-FGVCEVRDLKPNGANILVTE 4241
Cdd:smart00119 84 LLDLFFARPFYKKLLGKPVTLHDLESLDPELYKSLKWLlLNNDTSEE-LDLTFSIVLTSeFGQVKVVELKPGGSNIPVTE 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217390770 4242 ENKKEYVHLVCQMRMTGAIRKQLAAFLEGFYEIIPKRLISIFTEQELELLISGLPTIDIDDLKSNTEY-HKYQSNSIQIQ 4320
Cdd:smart00119 163 ENKKEYVHLVIEYRLNKGIEKQLEAFREGFSEVIPENLLKLFDPEELELLICGSPEIDVDDLKSNTEYkGGYSANSQTIK 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217390770 4321 WFWRALRSFDQADRAKFLQFVTGTSKVPLQGFAALEGmngiqKFQIHRDDRSTDRLPSAHTCFNQLDLPAYESFEKLRHM 4400
Cdd:smart00119 243 WFWEVVESFTNEERRKLLQFVTGSSRLPVGGFAALSP-----KFTIRKAGSDDERLPTAHTCFNRLKLPPYSSKEILREK 317
|
330
....*....|..
gi 2217390770 4401 LLLAIQECsEGF 4412
Cdd:smart00119 318 LLLAINEG-KGF 328
|
|
| HUL4 |
COG5021 |
Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]; |
3998-4415 |
6.66e-147 |
|
Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones];
Pssm-ID: 227354 [Multi-domain] Cd Length: 872 Bit Score: 482.73 E-value: 6.66e-147
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217390770 3998 RFAETHRTVLNQILRQSTTHL--ADGPFAVLVDYIRVLDFDVKRKYFRQeleRLDEGLRKEDMAVH--VRRDHVFEDSYR 4073
Cdd:COG5021 454 RLNNLYRFYFVEHRKKTLTKNdsRLGSFISLNKLDIRRIKEDKRRKLFY---SLKQKAKIFDPYLHikVRRDRVFEDSYR 530
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217390770 4074 ELHRKSPEEMKNRLYIVFEGEEGQDAGGLLREWYMIISREMFNPMYALFRTSPGDRVTYTINPSSHCNPNHLSYFKFVGR 4153
Cdd:COG5021 531 EIMDESGDDLKKTLEIEFVGEEGIDAGGLTREWLFLLSKEMFNPDYGLFEYITEDLYTLPINPLSSINPEHLSYFKFLGR 610
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217390770 4154 IVAKAVYDNRLLECYFTRSFYKHILGKSVRYTDMESEDYHFYQGLVYLLENDVSTLGYDLTFSTEVQEFGVCEVRDLKPN 4233
Cdd:COG5021 611 VIGKAIYDSRILDVQFSKAFYKKLLGKPVSLVDLESLDPELYRSLVWLLNNDIDETILDLTFTVEDDSFGESRTVELIPN 690
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217390770 4234 GANILVTEENKKEYVHLVCQMRMTGAIRKQLAAFLEGFYEIIPKRLISIFTEQELELLISGLPT-IDIDDLKSNTEYHKY 4312
Cdd:COG5021 691 GRNISVTNENKKEYVKKVVDYKLNKRVEKQFSAFKSGFSEIIPPDLLQIFDESELELLIGGIPEdIDIDDWKSNTAYHGY 770
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217390770 4313 QSNSIQIQWFWRALRSFDQADRAKFLQFVTGTSKVPLQGFAALEGMNGIQKFQIHRDDRSTDRLPSAHTCFNQLDLPAYE 4392
Cdd:COG5021 771 TEDSPIIVWFWEIISEFDFEERAKLLQFVTGTSRIPINGFKDLQGSDGVRKFTIEKGGTDDDRLPSAHTCFNRLKLPEYS 850
|
410 420
....*....|....*....|...
gi 2217390770 4393 SFEKLRHMLLLAIQECSeGFGLA 4415
Cdd:COG5021 851 SKEKLRSKLLTAINEGA-GFGLL 872
|
|
| HECT |
pfam00632 |
HECT-domain (ubiquitin-transferase); The name HECT comes from Homologous to the E6-AP Carboxyl ... |
4109-4415 |
2.04e-120 |
|
HECT-domain (ubiquitin-transferase); The name HECT comes from Homologous to the E6-AP Carboxyl Terminus.
Pssm-ID: 459880 Cd Length: 304 Bit Score: 383.88 E-value: 2.04e-120
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217390770 4109 IISREMFNPMYALFRTSPGDRVTYTINPSSHCNPNH--LSYFKFVGRIVAKAVYDNRLLECYFTRSFYKHILGKSVRYTD 4186
Cdd:pfam00632 2 LLSKELFDPNYGLFEYETEDDRTYWFNPSSSESPDLelLDYFKFLGKLLGKAIYNGILLDLPFPPFFYKKLLGEPLTLED 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217390770 4187 MESEDYHFYQGLVYLLENDVSTLG-YDLTFSteVQEFGVCEVRDLKPNGANILVTEENKKEYVHLVCQMRMTGAIRKQLA 4265
Cdd:pfam00632 82 LESIDPELYKSLKSLLNMDNDDDEdLGLTFT--IPVFGESKTIELIPNGRNIPVTNENKEEYIRLYVDYRLNKSIEPQLE 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217390770 4266 AFLEGFYEIIPKRLISIFTEQELELLISGLPTIDIDDLKSNTEY-HKYQSNSIQIQWFWRALRSFDQADRAKFLQFVTGT 4344
Cdd:pfam00632 160 AFRKGFYSVIPKEALSLFTPEELELLICGSPEIDVEDLKKNTEYdGGYTKNSPTIQWFWEILEEFSPEQRRLFLKFVTGS 239
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2217390770 4345 SKVPLQGFAALegmngiQKFQIHR-DDRSTDRLPSAHTCFNQLDLPAYESFEKLRHMLLLAIQECsEGFGLA 4415
Cdd:pfam00632 240 SRLPVGGFKSL------PKFTIVRkGGDDDDRLPTAHTCFNRLKLPDYSSKEILKEKLLIAIEEG-EGFGLS 304
|
|
| DUF913 |
pfam06025 |
Domain of Unknown Function (DUF913); Members of this family are found in various ubiquitin ... |
438-904 |
1.18e-95 |
|
Domain of Unknown Function (DUF913); Members of this family are found in various ubiquitin protein ligases.
Pssm-ID: 461803 Cd Length: 369 Bit Score: 315.32 E-value: 1.18e-95
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217390770 438 RAVRVVD-LITNLD--MAAFQSHSGLSIFIYRLEHEVDLCRKECpfvikpkiqrpnttQEGEEMETDMdvadvamessPG 514
Cdd:pfam06025 1 RAVQFLDtLIYNFQdaFQAFRNAGGLDAIIDRIVHEVDSALELA--------------EAGKGTPSEY----------KS 56
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217390770 515 SSISMEhrldvelrasgsssstnissgpspgpspgpgtgpgpgpgpgpgpgpgpgpgpgpgpgpgpgpgprpgvqcIP-Q 593
Cdd:pfam06025 57 SVVDYE----------------------------------------------------------------------IPyY 66
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217390770 594 RAALLKSMLNFLKKAIQ--DPAFSDGIRHVMDGS-LPTSLKHIISNAEYYGPSLFLLATEVVTVFVFQEPSLLSSLQDNG 670
Cdd:pfam06025 67 RQQLLKWLLKFIHHMMQhsGGGTDRLLRNLIDSSqLLGSLRKIIENAKVFGSSVWSLAVNILSDFIHNEPTSFAVIQEAG 146
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217390770 671 LTDVMLHALLIKDVPATREVLGSLPNVFSALCLNARGLQSFVQCQPFERLFKVLLSPDYLPAMRrrrssdPLGDTASNLG 750
Cdd:pfam06025 147 LSKAFLEAVLAKGILPSSEAINSIPNAFGAICLNNAGLELFKSSNALESFFEIFESPDHVKAME------TDGELASNLG 220
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217390770 751 SAVDELMRHQPTLKTDATTAIIKLLEEICNLGRDP--------KYICQKPSIQKADGTATAPPPRSNHAAEEASSEDEEE 822
Cdd:pfam06025 221 SSFDELVRHHPSLKPAIINAVIDMLARVVELGSTKaepdgwgaKLWVGCSSSSSFSPASSGSLPMETDGESGDESSSDED 300
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217390770 823 EEVQAMQSFNSTQQNETEPNQQvvgteeripiPLMDYILNVMKFVESILSNNTtddHCQEFVNQKGLLPLVTILGLPNLP 902
Cdd:pfam06025 301 VEMEDAPDTDSTEETEPESHGN----------SLTDYIDNVARFLEAFFSNNS---HCSDFIEKGGIELLLDLATLPSLP 367
|
..
gi 2217390770 903 ID 904
Cdd:pfam06025 368 YD 369
|
|
| DUF908 |
pfam06012 |
Domain of Unknown Function (DUF908); |
92-374 |
4.86e-23 |
|
Domain of Unknown Function (DUF908);
Pssm-ID: 428721 Cd Length: 351 Bit Score: 103.95 E-value: 4.86e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217390770 92 LLLAVLNFTALLIEYSFSRHLYSSIEHLTTLLASSDMQVVLAVLNLLYVFSKR-SNYITRLGSDKRTP-----------L 159
Cdd:pfam06012 5 LVEAILRFTRLLLENCGNRSIYNSSEHLNDLLNTTSLDVLLAALRLLLRLAQRySASNSRRGSAPRHIqqsllanhyniD 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217390770 160 LTRLQHLAESWG------------------GKENGFGLAECCRDLHmmKYPPS-ATTLHFEFYADPGAEVKIEK------ 214
Cdd:pfam06012 85 LDRLLKLAQPFPkppppdstdpapsttknsANEYANDLVSLAKEDS--KVLPSeWGSVKFTYYPSSSSDEAPTSskssts 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217390770 215 -----------------------------------RTTSNTLHYIHIEQLDKISESPSEIMESLtkMYSIPKDKQMLLFT 259
Cdd:pfam06012 163 snsspstptplrrsstlgtspdspsspststpssaADSDEGLRTFEIPESKVASKSLEDILAKA--IEDLPKESRFELLH 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217390770 260 HIRLAHGFSNHR--KRLQAVQARLHAISILVFVSPFAVYSNALQESANSILYnglieELVDVLQITDKQLMEIKAASLRT 337
Cdd:pfam06012 241 RIRIAKALNSSSeeSRQQLLAIRLLAIANLAYIHPESTFQTKLFEYDPDLVY-----QLAELIHPDTEVPLELQTAALYA 315
|
330 340 350
....*....|....*....|....*....|....*..
gi 2217390770 338 LTSIVHleRTPKLSSIIDCTGTASYHGFLPVLVRNCI 374
Cdd:pfam06012 316 LEALAR--HRAKLSDVLSALGANVNHGILLYVLRKAV 350
|
|
| UBA_HUWE1 |
cd14288 |
UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins; HUWE1, ... |
1407-1446 |
5.66e-15 |
|
UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins; HUWE1, also called ARF-binding protein 1 (ARF-BP1), HECT, UBA and WWE domain-containing protein 1, homologous to E6AP carboxyl terminus homologs protein 9 (HectH9), large structure of UREB1 (LASU1), Mcl-1 ubiquitin ligase E3 (Mule), upstream regulatory element-binding protein 1 (URE-B1), or URE-binding protein 1, may function as a ubiquitin-protein ligase that involves in the ubiquitination cascade that targets specific substrate proteins in proteolysis. It can ubiquitylate DNA polymerase beta (Pol beta), the major BER DNA polymerase and modulates base excision repair (BER). HUWE1 also acts as a critical mediator of both the p53-independent and p53-dependent tumor suppressor functions of ARF tumor suppressor in p53 regulation. Moreover, HUWE1 is both required and sufficient for the polyubiquitination of Mcl-1, an anti-apoptotic Bcl-2 family member involving in DNA damage-induced apoptosis. Furthermore, HUWE1 plays an important role in the regulation of Cdc6 stability after DNA damage. In addition, HUWE1 works as a partner of N-Myc oncoprotein in neural cells. It ubiquitinates N-Myc and primes it for proteasomal-mediated degradation. HUWE1 contains a ubiquitin-associated (UBA) domain, a WWE domain, and a Bcl-2 homology region 3 (BH3) domain at the N-terminus and a HECT domain at the C-terminus. WWE domain plays a role in the regulation of specific protein-protein interactions in a ubiquitin conjugation system. BH3 domain is responsible for the specific binding to Mcl-1. HECT domain involves in the inhibition of the transcriptional activity of p53 via a ubiquitin-dependent degradation pathway. It also controls neural differentiation and proliferation by destabilizing the N-Myc oncoprotein.
Pssm-ID: 270474 Cd Length: 40 Bit Score: 71.28 E-value: 5.66e-15
10 20 30 40
....*....|....*....|....*....|....*....|
gi 2217390770 1407 VNQQQLQQLMDMGFTREHAMEALLNTSTMEQATEYLLTHP 1446
Cdd:cd14288 1 VNEAHLQQLMDMGFTREHALEALLHTSTLEQATEYLLTHP 40
|
|
| WWE |
pfam02825 |
WWE domain; The WWE domain is named after three of its conserved residues and is predicted to ... |
1707-1768 |
4.50e-14 |
|
WWE domain; The WWE domain is named after three of its conserved residues and is predicted to mediate specific protein- protein interactions in ubiquitin and ADP ribose conjugation systems.
Pssm-ID: 460715 [Multi-domain] Cd Length: 66 Bit Score: 69.63 E-value: 4.50e-14
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2217390770 1707 WRWFDDRsGRWCSYSASNNSTIDSAWKSGETSV--RFTAGRRRYTVQFTTMVQVNEETGNRRPV 1768
Cdd:pfam02825 2 WEWEDDN-GGWHPYDPEVSSLIEEAYQKGKPSVdlSITTAGFPYTIDFKSMTQTNKDTGTTRPV 64
|
|
| WWE |
smart00678 |
Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated ... |
1707-1768 |
9.55e-12 |
|
Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis;
Pssm-ID: 128922 [Multi-domain] Cd Length: 73 Bit Score: 63.13 E-value: 9.55e-12
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2217390770 1707 WRW-FDDRSGRWCSYSASNNSTIDSAWKSGETSVRFTAGRRRYTVQFTTMVQVNEETGNRRPV 1768
Cdd:smart00678 1 YVWeYEGRNGKWWPYDPRVSEDIEEAYAAGKKLCELSICGFPYTIDFNAMTQYNQATGTTRKV 63
|
|
| UBM |
pfam14377 |
Ubiquitin binding region; This family contains repetitive element (RE) from a subgroup of HECT ... |
3066-3099 |
9.97e-08 |
|
Ubiquitin binding region; This family contains repetitive element (RE) from a subgroup of HECT E3 ubiquitin ligases and the Y-family translesion polymerases, including human HUWE1 and Arabidopsis UPL1. Each of these repetitive elements are approximately 20 amino acids in length and contain two predicted helical segments separated by a Leu-Pro motif. The REs from the Y-family polymerases were shown to bind ubiquitin and were the basis for a novel ubiquitin-binding domain called the ubiquitin-binding motif (UBM).
Pssm-ID: 464159 [Multi-domain] Cd Length: 34 Bit Score: 50.58 E-value: 9.97e-08
10 20 30
....*....|....*....|....*....|....
gi 2217390770 3066 GNPGVTEVSPEFLAALPPAIQEEVLAQQRAEQQR 3099
Cdd:pfam14377 1 AAPPPEGIDPSFLAALPPDLRQEVLAQQDDERLR 34
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
2791-3122 |
1.77e-06 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 54.94 E-value: 1.77e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217390770 2791 SDGTPMPDSYPTTPSSTDAAtSESKETLGTLQSSQQQPTLPTPPALGEVPQELQSPAGeggSSTQLLMPVEPEELGPTRP 2870
Cdd:PHA03247 2637 EPDPHPPPTVPPPERPRDDP-APGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTVG---SLTSLADPPPPPPTPEPAP 2712
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217390770 2871 SGEAETTQMELSPAPTITSLSPERAEDSDALTAVSSQLEGSPMDTSSLASctleeavgdTSAAGSSEQPRAgsstPGDAP 2950
Cdd:PHA03247 2713 HALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPT---------TAGPPAPAPPAA----PAAGP 2779
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217390770 2951 PAVAEVQGRSDGSGESAQPPEDSSPPASSESSSTRDSAVAISGADSRGileEPLPSTSSEEEDPLAGISLPEGVDPSFLA 3030
Cdd:PHA03247 2780 PRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGP---LPPPTSAQPTAPPPPPGPPPPSLPLGGSV 2856
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217390770 3031 ALPDDIRREVLQNQLGIRPPTRTAPSTNS-SAPAVVGNPGVTEVSPEFLAALP-PAIQEEVLAQQRAEQQRRE---LAQN 3105
Cdd:PHA03247 2857 APGGDVRRRPPSRSPAAKPAAPARPPVRRlARPAVSRSTESFALPPDQPERPPqPQAPPPPQPQPQPPPPPQPqppPPPP 2936
|
330
....*....|....*..
gi 2217390770 3106 ASSDTPMDPVTFIQTLP 3122
Cdd:PHA03247 2937 PRPQPPLAPTTDPAGAG 2953
|
|
| UBM |
pfam14377 |
Ubiquitin binding region; This family contains repetitive element (RE) from a subgroup of HECT ... |
3021-3048 |
1.98e-06 |
|
Ubiquitin binding region; This family contains repetitive element (RE) from a subgroup of HECT E3 ubiquitin ligases and the Y-family translesion polymerases, including human HUWE1 and Arabidopsis UPL1. Each of these repetitive elements are approximately 20 amino acids in length and contain two predicted helical segments separated by a Leu-Pro motif. The REs from the Y-family polymerases were shown to bind ubiquitin and were the basis for a novel ubiquitin-binding domain called the ubiquitin-binding motif (UBM).
Pssm-ID: 464159 [Multi-domain] Cd Length: 34 Bit Score: 47.11 E-value: 1.98e-06
10 20
....*....|....*....|....*...
gi 2217390770 3021 PEGVDPSFLAALPDDIRREVLQNQLGIR 3048
Cdd:pfam14377 5 PEGIDPSFLAALPPDLRQEVLAQQDDER 32
|
|
| Rev1_UBM2 |
cd19318 |
Ubiquitin-Binding Motif 2 (UBM2) of Y-family polymerase Rev1; This model characterizes UBM2, ... |
3024-3042 |
9.63e-03 |
|
Ubiquitin-Binding Motif 2 (UBM2) of Y-family polymerase Rev1; This model characterizes UBM2, the second ubiquitin-binding motif of Rev1, a DNA damage tolerance protein. Rev1 acts as a translesion synthesis (TLS) DNA polymerase and may also recruit other TLS polymerases to the site of DNA damage; in that process the UBMs are essential for Rev1 function, triggering TLS activation via recognition of ubiquitin moieties in PCNA, the proliferating cell nuclear antigen.
Pssm-ID: 412037 Cd Length: 36 Bit Score: 36.43 E-value: 9.63e-03
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| HECTc |
cd00078 |
HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It ... |
4060-4413 |
4.22e-161 |
|
HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ubiquitin molecules to the end of growing ubiquitin chains.
Pssm-ID: 238033 [Multi-domain] Cd Length: 352 Bit Score: 502.48 E-value: 4.22e-161
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217390770 4060 VHVRRDHVFEDSYRELHRKSPEEMKNRLYIVFEGEEGQDAGGLLREWYMIISREMFNPMYALFRTSPGDRVTYTINPSSH 4139
Cdd:cd00078 3 ITVRRDRILEDALRQLSKVSSSDLKKVLEVEFVGEEGIDAGGVTREFFTLVSKELFNPSYGLFRYTPDDSGLLYPNPSSF 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217390770 4140 CNPNHLSYFKFVGRIVAKAVYDNRLLECYFTRSFYKHILGKSVRYTDMESEDYHFYQGLVYLLENDVSTLGYDLTFSTEV 4219
Cdd:cd00078 83 ADEDHLKLFRFLGRLLGKALYEGRLLDLPFSRAFYKKLLGKPLSLEDLEELDPELYKSLKELLDNDGDEDDLELTFTIEL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217390770 4220 QE-FGVCEVRDLKPNGANILVTEENKKEYVHLVCQMRMTGAIRKQLAAFLEGFYEIIPKRLISIFTEQELELLISGLPTI 4298
Cdd:cd00078 163 DSsFGGAVTVELKPGGRDIPVTNENKEEYVDLYVDYRLNKGIEEQVEAFRDGFSEVIPEELLSLFTPEELELLICGSEDI 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217390770 4299 DIDDLKSNTEY-HKYQSNSIQIQWFWRALRSFDQADRAKFLQFVTGTSKVPLQGFAALEgmngiQKFQIHRDDRSTDRLP 4377
Cdd:cd00078 243 DLEDLKKNTEYkGGYSSDSPTIQWFWEVLESFTNEERKKFLQFVTGSSRLPVGGFADLN-----PKFTIRRVGSPDDRLP 317
|
330 340 350
....*....|....*....|....*....|....*.
gi 2217390770 4378 SAHTCFNQLDLPAYESFEKLRHMLLLAIQECsEGFG 4413
Cdd:cd00078 318 TAHTCFNLLKLPPYSSKEILREKLLYAINEG-AGFG 352
|
|
| HECTc |
smart00119 |
Domain Homologous to E6-AP Carboxyl Terminus with; E3 ubiquitin-protein ligases. Can bind to ... |
4084-4412 |
3.70e-159 |
|
Domain Homologous to E6-AP Carboxyl Terminus with; E3 ubiquitin-protein ligases. Can bind to E2 enzymes.
Pssm-ID: 214523 Cd Length: 328 Bit Score: 495.99 E-value: 3.70e-159
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217390770 4084 KNRLYIVFEGEEGQDAGGLLREWYMIISREMFNPMYALFRTSPGDRVTYTINPSSHCNPNHLSYFKFVGRIVAKAVYDNR 4163
Cdd:smart00119 4 KRVLEIEFEGEEGLDGGGVTREFFFLLSKELFNPDYGLFRYSPNDYLLYPNPRSGFANEEHLSYFRFIGRVLGKALYDNR 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217390770 4164 LLECYFTRSFYKHILGKSVRYTDMESEDYHFYQGLVYL-LENDVSTLgYDLTFSTEVQE-FGVCEVRDLKPNGANILVTE 4241
Cdd:smart00119 84 LLDLFFARPFYKKLLGKPVTLHDLESLDPELYKSLKWLlLNNDTSEE-LDLTFSIVLTSeFGQVKVVELKPGGSNIPVTE 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217390770 4242 ENKKEYVHLVCQMRMTGAIRKQLAAFLEGFYEIIPKRLISIFTEQELELLISGLPTIDIDDLKSNTEY-HKYQSNSIQIQ 4320
Cdd:smart00119 163 ENKKEYVHLVIEYRLNKGIEKQLEAFREGFSEVIPENLLKLFDPEELELLICGSPEIDVDDLKSNTEYkGGYSANSQTIK 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217390770 4321 WFWRALRSFDQADRAKFLQFVTGTSKVPLQGFAALEGmngiqKFQIHRDDRSTDRLPSAHTCFNQLDLPAYESFEKLRHM 4400
Cdd:smart00119 243 WFWEVVESFTNEERRKLLQFVTGSSRLPVGGFAALSP-----KFTIRKAGSDDERLPTAHTCFNRLKLPPYSSKEILREK 317
|
330
....*....|..
gi 2217390770 4401 LLLAIQECsEGF 4412
Cdd:smart00119 318 LLLAINEG-KGF 328
|
|
| HUL4 |
COG5021 |
Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]; |
3998-4415 |
6.66e-147 |
|
Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones];
Pssm-ID: 227354 [Multi-domain] Cd Length: 872 Bit Score: 482.73 E-value: 6.66e-147
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217390770 3998 RFAETHRTVLNQILRQSTTHL--ADGPFAVLVDYIRVLDFDVKRKYFRQeleRLDEGLRKEDMAVH--VRRDHVFEDSYR 4073
Cdd:COG5021 454 RLNNLYRFYFVEHRKKTLTKNdsRLGSFISLNKLDIRRIKEDKRRKLFY---SLKQKAKIFDPYLHikVRRDRVFEDSYR 530
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217390770 4074 ELHRKSPEEMKNRLYIVFEGEEGQDAGGLLREWYMIISREMFNPMYALFRTSPGDRVTYTINPSSHCNPNHLSYFKFVGR 4153
Cdd:COG5021 531 EIMDESGDDLKKTLEIEFVGEEGIDAGGLTREWLFLLSKEMFNPDYGLFEYITEDLYTLPINPLSSINPEHLSYFKFLGR 610
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217390770 4154 IVAKAVYDNRLLECYFTRSFYKHILGKSVRYTDMESEDYHFYQGLVYLLENDVSTLGYDLTFSTEVQEFGVCEVRDLKPN 4233
Cdd:COG5021 611 VIGKAIYDSRILDVQFSKAFYKKLLGKPVSLVDLESLDPELYRSLVWLLNNDIDETILDLTFTVEDDSFGESRTVELIPN 690
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217390770 4234 GANILVTEENKKEYVHLVCQMRMTGAIRKQLAAFLEGFYEIIPKRLISIFTEQELELLISGLPT-IDIDDLKSNTEYHKY 4312
Cdd:COG5021 691 GRNISVTNENKKEYVKKVVDYKLNKRVEKQFSAFKSGFSEIIPPDLLQIFDESELELLIGGIPEdIDIDDWKSNTAYHGY 770
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217390770 4313 QSNSIQIQWFWRALRSFDQADRAKFLQFVTGTSKVPLQGFAALEGMNGIQKFQIHRDDRSTDRLPSAHTCFNQLDLPAYE 4392
Cdd:COG5021 771 TEDSPIIVWFWEIISEFDFEERAKLLQFVTGTSRIPINGFKDLQGSDGVRKFTIEKGGTDDDRLPSAHTCFNRLKLPEYS 850
|
410 420
....*....|....*....|...
gi 2217390770 4393 SFEKLRHMLLLAIQECSeGFGLA 4415
Cdd:COG5021 851 SKEKLRSKLLTAINEGA-GFGLL 872
|
|
| HECT |
pfam00632 |
HECT-domain (ubiquitin-transferase); The name HECT comes from Homologous to the E6-AP Carboxyl ... |
4109-4415 |
2.04e-120 |
|
HECT-domain (ubiquitin-transferase); The name HECT comes from Homologous to the E6-AP Carboxyl Terminus.
Pssm-ID: 459880 Cd Length: 304 Bit Score: 383.88 E-value: 2.04e-120
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217390770 4109 IISREMFNPMYALFRTSPGDRVTYTINPSSHCNPNH--LSYFKFVGRIVAKAVYDNRLLECYFTRSFYKHILGKSVRYTD 4186
Cdd:pfam00632 2 LLSKELFDPNYGLFEYETEDDRTYWFNPSSSESPDLelLDYFKFLGKLLGKAIYNGILLDLPFPPFFYKKLLGEPLTLED 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217390770 4187 MESEDYHFYQGLVYLLENDVSTLG-YDLTFSteVQEFGVCEVRDLKPNGANILVTEENKKEYVHLVCQMRMTGAIRKQLA 4265
Cdd:pfam00632 82 LESIDPELYKSLKSLLNMDNDDDEdLGLTFT--IPVFGESKTIELIPNGRNIPVTNENKEEYIRLYVDYRLNKSIEPQLE 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217390770 4266 AFLEGFYEIIPKRLISIFTEQELELLISGLPTIDIDDLKSNTEY-HKYQSNSIQIQWFWRALRSFDQADRAKFLQFVTGT 4344
Cdd:pfam00632 160 AFRKGFYSVIPKEALSLFTPEELELLICGSPEIDVEDLKKNTEYdGGYTKNSPTIQWFWEILEEFSPEQRRLFLKFVTGS 239
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2217390770 4345 SKVPLQGFAALegmngiQKFQIHR-DDRSTDRLPSAHTCFNQLDLPAYESFEKLRHMLLLAIQECsEGFGLA 4415
Cdd:pfam00632 240 SRLPVGGFKSL------PKFTIVRkGGDDDDRLPTAHTCFNRLKLPDYSSKEILKEKLLIAIEEG-EGFGLS 304
|
|
| DUF913 |
pfam06025 |
Domain of Unknown Function (DUF913); Members of this family are found in various ubiquitin ... |
438-904 |
1.18e-95 |
|
Domain of Unknown Function (DUF913); Members of this family are found in various ubiquitin protein ligases.
Pssm-ID: 461803 Cd Length: 369 Bit Score: 315.32 E-value: 1.18e-95
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217390770 438 RAVRVVD-LITNLD--MAAFQSHSGLSIFIYRLEHEVDLCRKECpfvikpkiqrpnttQEGEEMETDMdvadvamessPG 514
Cdd:pfam06025 1 RAVQFLDtLIYNFQdaFQAFRNAGGLDAIIDRIVHEVDSALELA--------------EAGKGTPSEY----------KS 56
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217390770 515 SSISMEhrldvelrasgsssstnissgpspgpspgpgtgpgpgpgpgpgpgpgpgpgpgpgpgpgpgpgprpgvqcIP-Q 593
Cdd:pfam06025 57 SVVDYE----------------------------------------------------------------------IPyY 66
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217390770 594 RAALLKSMLNFLKKAIQ--DPAFSDGIRHVMDGS-LPTSLKHIISNAEYYGPSLFLLATEVVTVFVFQEPSLLSSLQDNG 670
Cdd:pfam06025 67 RQQLLKWLLKFIHHMMQhsGGGTDRLLRNLIDSSqLLGSLRKIIENAKVFGSSVWSLAVNILSDFIHNEPTSFAVIQEAG 146
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217390770 671 LTDVMLHALLIKDVPATREVLGSLPNVFSALCLNARGLQSFVQCQPFERLFKVLLSPDYLPAMRrrrssdPLGDTASNLG 750
Cdd:pfam06025 147 LSKAFLEAVLAKGILPSSEAINSIPNAFGAICLNNAGLELFKSSNALESFFEIFESPDHVKAME------TDGELASNLG 220
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217390770 751 SAVDELMRHQPTLKTDATTAIIKLLEEICNLGRDP--------KYICQKPSIQKADGTATAPPPRSNHAAEEASSEDEEE 822
Cdd:pfam06025 221 SSFDELVRHHPSLKPAIINAVIDMLARVVELGSTKaepdgwgaKLWVGCSSSSSFSPASSGSLPMETDGESGDESSSDED 300
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217390770 823 EEVQAMQSFNSTQQNETEPNQQvvgteeripiPLMDYILNVMKFVESILSNNTtddHCQEFVNQKGLLPLVTILGLPNLP 902
Cdd:pfam06025 301 VEMEDAPDTDSTEETEPESHGN----------SLTDYIDNVARFLEAFFSNNS---HCSDFIEKGGIELLLDLATLPSLP 367
|
..
gi 2217390770 903 ID 904
Cdd:pfam06025 368 YD 369
|
|
| DUF908 |
pfam06012 |
Domain of Unknown Function (DUF908); |
92-374 |
4.86e-23 |
|
Domain of Unknown Function (DUF908);
Pssm-ID: 428721 Cd Length: 351 Bit Score: 103.95 E-value: 4.86e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217390770 92 LLLAVLNFTALLIEYSFSRHLYSSIEHLTTLLASSDMQVVLAVLNLLYVFSKR-SNYITRLGSDKRTP-----------L 159
Cdd:pfam06012 5 LVEAILRFTRLLLENCGNRSIYNSSEHLNDLLNTTSLDVLLAALRLLLRLAQRySASNSRRGSAPRHIqqsllanhyniD 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217390770 160 LTRLQHLAESWG------------------GKENGFGLAECCRDLHmmKYPPS-ATTLHFEFYADPGAEVKIEK------ 214
Cdd:pfam06012 85 LDRLLKLAQPFPkppppdstdpapsttknsANEYANDLVSLAKEDS--KVLPSeWGSVKFTYYPSSSSDEAPTSskssts 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217390770 215 -----------------------------------RTTSNTLHYIHIEQLDKISESPSEIMESLtkMYSIPKDKQMLLFT 259
Cdd:pfam06012 163 snsspstptplrrsstlgtspdspsspststpssaADSDEGLRTFEIPESKVASKSLEDILAKA--IEDLPKESRFELLH 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217390770 260 HIRLAHGFSNHR--KRLQAVQARLHAISILVFVSPFAVYSNALQESANSILYnglieELVDVLQITDKQLMEIKAASLRT 337
Cdd:pfam06012 241 RIRIAKALNSSSeeSRQQLLAIRLLAIANLAYIHPESTFQTKLFEYDPDLVY-----QLAELIHPDTEVPLELQTAALYA 315
|
330 340 350
....*....|....*....|....*....|....*..
gi 2217390770 338 LTSIVHleRTPKLSSIIDCTGTASYHGFLPVLVRNCI 374
Cdd:pfam06012 316 LEALAR--HRAKLSDVLSALGANVNHGILLYVLRKAV 350
|
|
| UBA_HUWE1 |
cd14288 |
UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins; HUWE1, ... |
1407-1446 |
5.66e-15 |
|
UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins; HUWE1, also called ARF-binding protein 1 (ARF-BP1), HECT, UBA and WWE domain-containing protein 1, homologous to E6AP carboxyl terminus homologs protein 9 (HectH9), large structure of UREB1 (LASU1), Mcl-1 ubiquitin ligase E3 (Mule), upstream regulatory element-binding protein 1 (URE-B1), or URE-binding protein 1, may function as a ubiquitin-protein ligase that involves in the ubiquitination cascade that targets specific substrate proteins in proteolysis. It can ubiquitylate DNA polymerase beta (Pol beta), the major BER DNA polymerase and modulates base excision repair (BER). HUWE1 also acts as a critical mediator of both the p53-independent and p53-dependent tumor suppressor functions of ARF tumor suppressor in p53 regulation. Moreover, HUWE1 is both required and sufficient for the polyubiquitination of Mcl-1, an anti-apoptotic Bcl-2 family member involving in DNA damage-induced apoptosis. Furthermore, HUWE1 plays an important role in the regulation of Cdc6 stability after DNA damage. In addition, HUWE1 works as a partner of N-Myc oncoprotein in neural cells. It ubiquitinates N-Myc and primes it for proteasomal-mediated degradation. HUWE1 contains a ubiquitin-associated (UBA) domain, a WWE domain, and a Bcl-2 homology region 3 (BH3) domain at the N-terminus and a HECT domain at the C-terminus. WWE domain plays a role in the regulation of specific protein-protein interactions in a ubiquitin conjugation system. BH3 domain is responsible for the specific binding to Mcl-1. HECT domain involves in the inhibition of the transcriptional activity of p53 via a ubiquitin-dependent degradation pathway. It also controls neural differentiation and proliferation by destabilizing the N-Myc oncoprotein.
Pssm-ID: 270474 Cd Length: 40 Bit Score: 71.28 E-value: 5.66e-15
10 20 30 40
....*....|....*....|....*....|....*....|
gi 2217390770 1407 VNQQQLQQLMDMGFTREHAMEALLNTSTMEQATEYLLTHP 1446
Cdd:cd14288 1 VNEAHLQQLMDMGFTREHALEALLHTSTLEQATEYLLTHP 40
|
|
| WWE |
pfam02825 |
WWE domain; The WWE domain is named after three of its conserved residues and is predicted to ... |
1707-1768 |
4.50e-14 |
|
WWE domain; The WWE domain is named after three of its conserved residues and is predicted to mediate specific protein- protein interactions in ubiquitin and ADP ribose conjugation systems.
Pssm-ID: 460715 [Multi-domain] Cd Length: 66 Bit Score: 69.63 E-value: 4.50e-14
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2217390770 1707 WRWFDDRsGRWCSYSASNNSTIDSAWKSGETSV--RFTAGRRRYTVQFTTMVQVNEETGNRRPV 1768
Cdd:pfam02825 2 WEWEDDN-GGWHPYDPEVSSLIEEAYQKGKPSVdlSITTAGFPYTIDFKSMTQTNKDTGTTRPV 64
|
|
| WWE |
smart00678 |
Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated ... |
1707-1768 |
9.55e-12 |
|
Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis;
Pssm-ID: 128922 [Multi-domain] Cd Length: 73 Bit Score: 63.13 E-value: 9.55e-12
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2217390770 1707 WRW-FDDRSGRWCSYSASNNSTIDSAWKSGETSVRFTAGRRRYTVQFTTMVQVNEETGNRRPV 1768
Cdd:smart00678 1 YVWeYEGRNGKWWPYDPRVSEDIEEAYAAGKKLCELSICGFPYTIDFNAMTQYNQATGTTRKV 63
|
|
| UBM |
pfam14377 |
Ubiquitin binding region; This family contains repetitive element (RE) from a subgroup of HECT ... |
3066-3099 |
9.97e-08 |
|
Ubiquitin binding region; This family contains repetitive element (RE) from a subgroup of HECT E3 ubiquitin ligases and the Y-family translesion polymerases, including human HUWE1 and Arabidopsis UPL1. Each of these repetitive elements are approximately 20 amino acids in length and contain two predicted helical segments separated by a Leu-Pro motif. The REs from the Y-family polymerases were shown to bind ubiquitin and were the basis for a novel ubiquitin-binding domain called the ubiquitin-binding motif (UBM).
Pssm-ID: 464159 [Multi-domain] Cd Length: 34 Bit Score: 50.58 E-value: 9.97e-08
10 20 30
....*....|....*....|....*....|....
gi 2217390770 3066 GNPGVTEVSPEFLAALPPAIQEEVLAQQRAEQQR 3099
Cdd:pfam14377 1 AAPPPEGIDPSFLAALPPDLRQEVLAQQDDERLR 34
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
2791-3122 |
1.77e-06 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 54.94 E-value: 1.77e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217390770 2791 SDGTPMPDSYPTTPSSTDAAtSESKETLGTLQSSQQQPTLPTPPALGEVPQELQSPAGeggSSTQLLMPVEPEELGPTRP 2870
Cdd:PHA03247 2637 EPDPHPPPTVPPPERPRDDP-APGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTVG---SLTSLADPPPPPPTPEPAP 2712
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217390770 2871 SGEAETTQMELSPAPTITSLSPERAEDSDALTAVSSQLEGSPMDTSSLASctleeavgdTSAAGSSEQPRAgsstPGDAP 2950
Cdd:PHA03247 2713 HALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPT---------TAGPPAPAPPAA----PAAGP 2779
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217390770 2951 PAVAEVQGRSDGSGESAQPPEDSSPPASSESSSTRDSAVAISGADSRGileEPLPSTSSEEEDPLAGISLPEGVDPSFLA 3030
Cdd:PHA03247 2780 PRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGP---LPPPTSAQPTAPPPPPGPPPPSLPLGGSV 2856
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217390770 3031 ALPDDIRREVLQNQLGIRPPTRTAPSTNS-SAPAVVGNPGVTEVSPEFLAALP-PAIQEEVLAQQRAEQQRRE---LAQN 3105
Cdd:PHA03247 2857 APGGDVRRRPPSRSPAAKPAAPARPPVRRlARPAVSRSTESFALPPDQPERPPqPQAPPPPQPQPQPPPPPQPqppPPPP 2936
|
330
....*....|....*..
gi 2217390770 3106 ASSDTPMDPVTFIQTLP 3122
Cdd:PHA03247 2937 PRPQPPLAPTTDPAGAG 2953
|
|
| UBM |
pfam14377 |
Ubiquitin binding region; This family contains repetitive element (RE) from a subgroup of HECT ... |
3021-3048 |
1.98e-06 |
|
Ubiquitin binding region; This family contains repetitive element (RE) from a subgroup of HECT E3 ubiquitin ligases and the Y-family translesion polymerases, including human HUWE1 and Arabidopsis UPL1. Each of these repetitive elements are approximately 20 amino acids in length and contain two predicted helical segments separated by a Leu-Pro motif. The REs from the Y-family polymerases were shown to bind ubiquitin and were the basis for a novel ubiquitin-binding domain called the ubiquitin-binding motif (UBM).
Pssm-ID: 464159 [Multi-domain] Cd Length: 34 Bit Score: 47.11 E-value: 1.98e-06
10 20
....*....|....*....|....*...
gi 2217390770 3021 PEGVDPSFLAALPDDIRREVLQNQLGIR 3048
Cdd:pfam14377 5 PEGIDPSFLAALPPDLRQEVLAQQDDER 32
|
|
| Herpes_BLLF1 |
pfam05109 |
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ... |
2778-3014 |
8.91e-06 |
|
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.
Pssm-ID: 282904 [Multi-domain] Cd Length: 886 Bit Score: 52.23 E-value: 8.91e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217390770 2778 TASKSNDSTEQNLSDGTPMPDSYPTTPSSTDAATSESKETLGTlQSSQQQPTLPTPPALGEVPQeLQSPAGEGGSSTqll 2857
Cdd:pfam05109 499 TESKAPDMTSPTSAVTTPTPNATSPTPAVTTPTPNATSPTLGK-TSPTSAVTTPTPNATSPTPA-VTTPTPNATIPT--- 573
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217390770 2858 mpvepeeLGPTRPSgEAETTQMELSPAPTITSLSPERAEDSDALTAVSSqlegSPMDTSSLASCTLEEAVGDTSAAGSSe 2937
Cdd:pfam05109 574 -------LGKTSPT-SAVTTPTPNATSPTVGETSPQANTTNHTLGGTSS----TPVVTSPPKNATSAVTTGQHNITSSS- 640
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2217390770 2938 qpragSSTPGDAPPAVAEVQGRSDGSGESAQPPEDSSPPASSESSSTRDSAVAISGADSRGILEEPLPSTSSEEEDP 3014
Cdd:pfam05109 641 -----TSSMSLRPSSISETLSPSTSDNSTSHMPLLTSAHPTGGENITQVTPASTSTHHVSTSSPAPRPGTTSQASGP 712
|
|
| Herpes_BLLF1 |
pfam05109 |
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ... |
2778-3084 |
1.56e-05 |
|
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.
Pssm-ID: 282904 [Multi-domain] Cd Length: 886 Bit Score: 51.46 E-value: 1.56e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217390770 2778 TASKSNDSTEQNLSDGTPMPDSYPTTPSSTDAATSESKETLGtLQSSQQQPT-LPTPPALGEV--PQELQSPAGEGGSST 2854
Cdd:pfam05109 406 TRTATNATTTTHKVIFSKAPESTTTSPTLNTTGFAAPNTTTG-LPSSTHVPTnLTAPASTGPTvsTADVTSPTPAGTTSG 484
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217390770 2855 QllMPVEP---------EELGP--TRPSGEAET-TQMELSPAPTITSLSPERAEDSDALTAVSSQLEG-SPMDTSSLASC 2921
Cdd:pfam05109 485 A--SPVTPspsprdngtESKAPdmTSPTSAVTTpTPNATSPTPAVTTPTPNATSPTLGKTSPTSAVTTpTPNATSPTPAV 562
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217390770 2922 TLEE------AVGDTS--AAGSSEQPRAGSSTPGDAPPAVAEVQGRSDGSGES---AQPPEDSSPPASSESSSTRDSAVA 2990
Cdd:pfam05109 563 TTPTpnatipTLGKTSptSAVTTPTPNATSPTVGETSPQANTTNHTLGGTSSTpvvTSPPKNATSAVTTGQHNITSSSTS 642
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217390770 2991 ISGADSRGILEEPLPSTS--SEEEDPLAGISLPEGVDPSFLAALPDDIRREVLQNQLGIRPPTRTAPS--TNSSAPAVVG 3066
Cdd:pfam05109 643 SMSLRPSSISETLSPSTSdnSTSHMPLLTSAHPTGGENITQVTPASTSTHHVSTSSPAPRPGTTSQASgpGNSSTSTKPG 722
|
330
....*....|....*...
gi 2217390770 3067 NPGVTEVSPEFLAALPPA 3084
Cdd:pfam05109 723 EVNVTKGTPPKNATSPQA 740
|
|
| DUF5585 |
pfam17823 |
Family of unknown function (DUF5585); This is a family of unknown function found in chordata. |
2760-3095 |
2.97e-05 |
|
Family of unknown function (DUF5585); This is a family of unknown function found in chordata.
Pssm-ID: 465521 [Multi-domain] Cd Length: 506 Bit Score: 49.96 E-value: 2.97e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217390770 2760 ITDKGKEDKENRDQSAQCTASKSNDSTEQNLSDGTPMPDSYPTTPSSTDAATSESKETlgTLQSSQQQPTLPTP-----P 2834
Cdd:pfam17823 29 VLNKMWNGAGKQNASGDAVPRADNKSSEQ*NFCAATAAPAPVTLTKGTSAAHLNSTEV--TAEHTPHGTDLSEPatregA 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217390770 2835 ALGEVPQELQSPAGEGGSSTQLLMPVE---PEELGPTRPSGEAETTQMELSP--------APTITSLSPERAEDSDALTA 2903
Cdd:pfam17823 107 ADGAASRALAAAASSSPSSAAQSLPAAiaaLPSEAFSAPRAAACRANASAAPraaiaaasAPHAASPAPRTAASSTTAAS 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217390770 2904 VSSQLEGSPMDTSSLASCTLEEAVGDTSAAGSSEQPRAGSSTPgdAPPAVAEVQGRSDGSGESAQPPEDSSPPASSESSS 2983
Cdd:pfam17823 187 STTAASSAPTTAASSAPATLTPARGISTAATATGHPAAGTALA--AVGNSSPAAGTVTAAVGTVTPAALATLAAAAGTVA 264
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217390770 2984 TRDSAVAISGADSR-----------GILEEPLPSTSSEEEDPLAGISL--------PEGVDPSFLAALPDDIRREVLQNQ 3044
Cdd:pfam17823 265 SAAGTINMGDPHARrlspakhmpsdTMARNPAAPMGAQAQGPIIQVSTdqpvhntaGEPTPSPSNTTLEPNTPKSVASTN 344
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 2217390770 3045 LGIRPPTRTAPSTNSSAPAVVGNpgvTEVSPEFLAALPPAIQEEVLAQQRA 3095
Cdd:pfam17823 345 LAVVTTTKAQAKEPSASPVPVLH---TSMIPEVEATSPTTQPSPLLPTQGA 392
|
|
| PRK07764 |
PRK07764 |
DNA polymerase III subunits gamma and tau; Validated |
2827-3049 |
4.14e-05 |
|
DNA polymerase III subunits gamma and tau; Validated
Pssm-ID: 236090 [Multi-domain] Cd Length: 824 Bit Score: 49.98 E-value: 4.14e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217390770 2827 QPTLPTPPALGEVPQELQSPAGeggsstqllmPVEPEELGPTRPSGEAeTTQMELSPAPTITSLSPERAEDSDALTAVSS 2906
Cdd:PRK07764 596 GGEGPPAPASSGPPEEAARPAA----------PAAPAAPAAPAPAGAA-AAPAEASAAPAPGVAAPEHHPKHVAVPDASD 664
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217390770 2907 QLEGSPMDTSSLASCTLEEA------VGDTSAAGSSEQPR-------AGSSTPGDAPPAVAEVQGRSDGSGESAQPPEDS 2973
Cdd:PRK07764 665 GGDGWPAKAGGAAPAAPPPApapaapAAPAGAAPAQPAPApaatppaGQADDPAAQPPQAAQGASAPSPAADDPVPLPPE 744
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2217390770 2974 SPPASSESSSTRDSAVAISGADSRGILEEPLPSTSSEEEDPLAgiSLPEGVDPSFLAAlPDDIRREVLQNQLGIRP 3049
Cdd:PRK07764 745 PDDPPDPAGAPAQPPPPPAPAPAAAPAAAPPPSPPSEEEEMAE--DDAPSMDDEDRRD-AEEVAMELLEEELGAKK 817
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
2797-3182 |
5.67e-05 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 49.94 E-value: 5.67e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217390770 2797 PDSYPTTPSSTDAATSESKETLGTLQSSQQQPTLPTPPALGEVPQELQSPAGEG-----------GSSTQLLMPVEPEEL 2865
Cdd:PHA03247 2702 PPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPArparppttagpPAPAPPAAPAAGPPR 2781
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217390770 2866 GPTRPSGEAETTQMELSPAPTITSLSPERAED-SDALTAVSSQLEGSPMDTSSL------------ASCTLEEAV---GD 2929
Cdd:PHA03247 2782 RLTRPAVASLSESRESLPSPWDPADPPAAVLApAAALPPAASPAGPLPPPTSAQptapppppgpppPSLPLGGSVapgGD 2861
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217390770 2930 TSAAGSSEQPRAGSSTPGDaPPAVAEVQGRSDGSGESAQPPEDSSPPASSESSSTRDSAVAISGADSRgilEEPLPSTSS 3009
Cdd:PHA03247 2862 VRRRPPSRSPAAKPAAPAR-PPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQ---PQPPPPPPP 2937
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217390770 3010 EEEDPL------AGISLPEGVDPSFLAALPDDIRREVLQNQLGIRPPTRTAPSTNSSAPAVVGNPGVTEVSpeflaalpp 3083
Cdd:PHA03247 2938 RPQPPLapttdpAGAGEPSGAVPQPWLGALVPGRVAVPRFRVPQPAPSREAPASSTPPLTGHSLSRVSSWA--------- 3008
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217390770 3084 aiqeevlaqqraeqqrRELAQNASSDTPmdPVTFIQTL-PSD---------LRRSVLEDMEDSVLAVMPPD----IAAEA 3149
Cdd:PHA03247 3009 ----------------SSLALHEETDPP--PVSLKQTLwPPDdtedsdadsLFDSDSERSDLEALDPLPPEphdpFAHEP 3070
|
410 420 430
....*....|....*....|....*....|...
gi 2217390770 3150 QALRREQEARQRQLMHerlFGHSSTSALSAILR 3182
Cdd:PHA03247 3071 DPATPEAGARESPSSQ---FGPPPLSANAALSR 3100
|
|
| PHA03169 |
PHA03169 |
hypothetical protein; Provisional |
2766-2969 |
1.47e-04 |
|
hypothetical protein; Provisional
Pssm-ID: 223003 [Multi-domain] Cd Length: 413 Bit Score: 47.66 E-value: 1.47e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217390770 2766 EDKENRDQSAQCTASKSNDSTEQNLSDGTPMPDSYPTTpSSTDAATSESKETLGtlQSSQQQPTLPTPPALGEVPQELQS 2845
Cdd:PHA03169 63 EQGHRQTESDTETAEESRHGEKEERGQGGPSGSGSESV-GSPTPSPSGSAEELA--SGLSPENTSGSSPESPASHSPPPS 139
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217390770 2846 PAGEGGSSTqllmPVEPEELGPT---RPSGEAE-TTQMELSPAPTITSLSPERAEDS-DALTAVSSQLEGSPMDTSSL-A 2919
Cdd:PHA03169 140 PPSHPGPHE----PAPPESHNPSpnqQPSSFLQpSHEDSPEEPEPPTSEPEPDSPGPpQSETPTSSPPPQSPPDEPGEpQ 215
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|.
gi 2217390770 2920 SCTLEEA-VGDTSAAGSSEQPRAGSSTPGDAPPAVAEVQGRSDGSGESAQP 2969
Cdd:PHA03169 216 SPTPQQApSPNTQQAVEHEDEPTEPEREGPPFPGHRSHSYTVVGWKPSTRP 266
|
|
| UBA_atUPL1_2_like |
cd14327 |
UBA domain found in Arabidopsis thaliana E3 ubiquitin-protein ligase UPL1 (atUPL1), UPL2 ... |
1416-1445 |
2.41e-04 |
|
UBA domain found in Arabidopsis thaliana E3 ubiquitin-protein ligase UPL1 (atUPL1), UPL2 (atUPL2) and similar proteins; The family includes two highly similar 405-kDa HECT E3 ubiquitin-protein ligases (UPLs), UPL1 and UPL2, from Arabidopsis thaliana. The HECT E3 UPL family plays a prominent role in the ubiquitination of plant proteins. The biological functions of UPL1 and UPL2 remain unclear. Both of them contain a ubiquitin-associated (UBA) domain and a C-terminal HECT domain. UBA domain may be involved in ubiquitin metabolism. HECT domain is necessary and sufficient for their E3 catalytic activity, but requires ATP, E1 and an E2 of the Arabidopsis UBC8 family to ubiquitinate proteins.
Pssm-ID: 270512 [Multi-domain] Cd Length: 38 Bit Score: 41.13 E-value: 2.41e-04
10 20 30
....*....|....*....|....*....|..
gi 2217390770 1416 MDMGFTREHAMEAL--LNTSTMEQATEYLLTH 1445
Cdd:cd14327 7 VEMGFSRERAEEALraVGTNSVELAMEWLFTN 38
|
|
| PRK07003 |
PRK07003 |
DNA polymerase III subunit gamma/tau; |
2833-3106 |
2.09e-03 |
|
DNA polymerase III subunit gamma/tau;
Pssm-ID: 235906 [Multi-domain] Cd Length: 830 Bit Score: 44.46 E-value: 2.09e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217390770 2833 PPALGEVPQELQSPAGEGGSSTQLLMPVEPEELGPTRPSGEAETTQMELSPAPTITSLSPERAEDSDALTAVSSQLEGSP 2912
Cdd:PRK07003 368 PGGGVPARVAGAVPAPGARAAAAVGASAVPAVTAVTGAAGAALAPKAAAAAAATRAEAPPAAPAPPATADRGDDAADGDA 447
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217390770 2913 MDTSSLASCTLEEAVGDTSAAGSSEQPRAGSSTPGDAPPAVA-EVQGRSDGSGESAQPPEDSSPPASsessstrdsavAI 2991
Cdd:PRK07003 448 PVPAKANARASADSRCDERDAQPPADSGSASAPASDAPPDAAfEPAPRAAAPSAATPAAVPDARAPA-----------AA 516
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217390770 2992 SGADSRGILEEPLPSTSSEEedPLAGISLPEGVDPSflAALpddirrEVLQNQlGIRpptrtAPSTNSSAPAVVGNPGVT 3071
Cdd:PRK07003 517 SREDAPAAAAPPAPEARPPT--PAAAAPAARAGGAA--AAL------DVLRNA-GMR-----VSSDRGARAAAAAKPAAA 580
|
250 260 270
....*....|....*....|....*....|....*.
gi 2217390770 3072 EVSPEFLAALPPAIQEEVL-AQQRAEQQRRELAQNA 3106
Cdd:PRK07003 581 PAAAPKPAAPRVAVQVPTPrARAATGDAPPNGAARA 616
|
|
| PHA03307 |
PHA03307 |
transcriptional regulator ICP4; Provisional |
2798-3075 |
6.00e-03 |
|
transcriptional regulator ICP4; Provisional
Pssm-ID: 223039 [Multi-domain] Cd Length: 1352 Bit Score: 42.85 E-value: 6.00e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217390770 2798 DSYPTTPSSTDAATSESKETLGTLQSSQQQPTLPTPPALGEVPQELQSPAGEGGSSTQLlMPVEPEELGPTRPSGEAETT 2877
Cdd:PHA03307 60 AACDRFEPPTGPPPGPGTEAPANESRSTPTWSLSTLAPASPAREGSPTPPGPSSPDPPP-PTPPPASPPPSPAPDLSEML 138
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217390770 2878 QMELSPAPtitslspeRAEDSDALTAVSSQLEGSPMDTSSLASCTLEeAVGDTSAAGSSEQPRAGSSTPGDAPPAVAEVQ 2957
Cdd:PHA03307 139 RPVGSPGP--------PPAASPPAAGASPAAVASDAASSRQAALPLS-SPEETARAPSSPPAEPPPSTPPAAASPRPPRR 209
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217390770 2958 GRSDGSGesaqppedssppassesssTRDSAVAISGADSRGILEEPLPSTSSEEEDPLAGISLPEGVDPSFLAALPDDIR 3037
Cdd:PHA03307 210 SSPISAS-------------------ASSPAPAPGRSAADDAGASSSDSSSSESSGCGWGPENECPLPRPAPITLPTRIW 270
|
250 260 270 280
....*....|....*....|....*....|....*....|
gi 2217390770 3038 REVLQNQLGIRP-PTRTAPSTNSSAPAVV-GNPGVTEVSP 3075
Cdd:PHA03307 271 EASGWNGPSSRPgPASSSSSPRERSPSPSpSSPGSGPAPS 310
|
|
| PHA03169 |
PHA03169 |
hypothetical protein; Provisional |
2759-3021 |
8.09e-03 |
|
hypothetical protein; Provisional
Pssm-ID: 223003 [Multi-domain] Cd Length: 413 Bit Score: 41.88 E-value: 8.09e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217390770 2759 KITDKGKEDKENRDQSAQCTAS-KSNDSTEQNLSDGTPMPDSYPTTPSSTDAATSE---SKETLGtlQSSQQqptlptpp 2834
Cdd:PHA03169 24 KRHGGTREQAGRRRGTAARAAKpAPPAPTTSGPQVRAVAEQGHRQTESDTETAEESrhgEKEERG--QGGPS-------- 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217390770 2835 alGEVPQELQSP-AGEGGSStqllmPVEPEELGPTRPSGEAETTQMELSPAPTitslspERAEDSDALTAVSSQLEGSPM 2913
Cdd:PHA03169 94 --GSGSESVGSPtPSPSGSA-----EELASGLSPENTSGSSPESPASHSPPPS------PPSHPGPHEPAPPESHNPSPN 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217390770 2914 DT-SSLASCTLEEavGDTSAAGSSEQPRAGSSTPGDAPpavaevqgrsdgSGESAQPPEDSSPPASSESSSTRDSAVAIS 2992
Cdd:PHA03169 161 QQpSSFLQPSHED--SPEEPEPPTSEPEPDSPGPPQSE------------TPTSSPPPQSPPDEPGEPQSPTPQQAPSPN 226
|
250 260
....*....|....*....|....*....
gi 2217390770 2993 GADsrGILEEPLPSTSSEEEDPLAGISLP 3021
Cdd:PHA03169 227 TQQ--AVEHEDEPTEPEREGPPFPGHRSH 253
|
|
| Rev1_UBM2 |
cd19318 |
Ubiquitin-Binding Motif 2 (UBM2) of Y-family polymerase Rev1; This model characterizes UBM2, ... |
3024-3042 |
9.63e-03 |
|
Ubiquitin-Binding Motif 2 (UBM2) of Y-family polymerase Rev1; This model characterizes UBM2, the second ubiquitin-binding motif of Rev1, a DNA damage tolerance protein. Rev1 acts as a translesion synthesis (TLS) DNA polymerase and may also recruit other TLS polymerases to the site of DNA damage; in that process the UBMs are essential for Rev1 function, triggering TLS activation via recognition of ubiquitin moieties in PCNA, the proliferating cell nuclear antigen.
Pssm-ID: 412037 Cd Length: 36 Bit Score: 36.43 E-value: 9.63e-03
|
| |
