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Conserved domains on  [gi|2217423609|ref|XP_047299038|]
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double homeobox protein 4 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Homeodomain pfam00046
Homeodomain;
95-149 3.33e-21

Homeodomain;


:

Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 86.40  E-value: 3.33e-21
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2217423609  95 RRKRTAVTGSQTALLLRAFEKDRFPGIAAREELARETGLPESRIQIWFQNRRARH 149
Cdd:pfam00046   1 RRKRTTFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKW 55
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 25-78 5.92e-17

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


:

Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 74.59  E-value: 5.92e-17
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2217423609  25 VWTPSQSEALRACFERNPYPGIATRERLAQAIGIPEPRVQIWFQNERSRQLRQH 78
Cdd:cd00086     6 RFTPEQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRAKLKRSE 59
PRK07764 super family cl35613
DNA polymerase III subunits gamma and tau; Validated
 141-319 5.05e-06

DNA polymerase III subunits gamma and tau; Validated


The actual alignment was detected with superfamily member PRK07764:

Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 48.83  E-value: 5.05e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217423609 141 WFQNRRARHPGQGGRAPAQAGglcsAAPGGGHPAPSwvAFAHTGAWGTGLPAPHVPCAPGALPQGAFVSQAARAAPALQP 220
Cdd:PRK07764  606 SGPPEEAARPAAPAAPAAPAA----PAPAGAAAAPA--EASAAPAPGVAAPEHHPKHVAVPDASDGGDGWPAKAGGAAPA 679

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217423609 221 SQAAPAEGISQPAPARGDFAYAAPAPPDGALSHPQAPRWPPHPGKSREDRDPQRDGLPGPCAVAQPGPAQAGPQGQGVLA 300
Cdd:PRK07764  680 APPPAPAPAAPAAPAGAAPAQPAPAPAATPPAGQADDPAAQPPQAAQGASAPSPAADDPVPLPPEPDDPPDPAGAPAQPP 759

                         170
                  ....*....|....*....
gi 2217423609 301 PPTSQGSPwWGWGRGPQVA 319
Cdd:PRK07764  760 PPPAPAPA-AAPAAAPPPS 777
 
Name Accession Description Interval E-value
Homeodomain pfam00046
Homeodomain;
95-149 3.33e-21

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 86.40  E-value: 3.33e-21
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2217423609  95 RRKRTAVTGSQTALLLRAFEKDRFPGIAAREELARETGLPESRIQIWFQNRRARH 149
Cdd:pfam00046   1 RRKRTTFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKW 55
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 95-149 2.30e-19

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 81.14  E-value: 2.30e-19
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2217423609  95 RRKRTAVTGSQTALLLRAFEKDRFPGIAAREELARETGLPESRIQIWFQNRRARH 149
Cdd:cd00086     1 RRKRTRFTPEQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRAKL 55
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 94-149 2.36e-19

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 81.14  E-value: 2.36e-19
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 2217423609   94 GRRKRTAVTGSQTALLLRAFEKDRFPGIAAREELARETGLPESRIQIWFQNRRARH 149
Cdd:smart00389   1 KRRKRTSFTPEQLEELEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQNRRAKW 56
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 25-78 5.92e-17

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 74.59  E-value: 5.92e-17
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2217423609  25 VWTPSQSEALRACFERNPYPGIATRERLAQAIGIPEPRVQIWFQNERSRQLRQH 78
Cdd:cd00086     6 RFTPEQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRAKLKRSE 59
Homeodomain pfam00046
Homeodomain;
27-74 6.96e-16

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 71.38  E-value: 6.96e-16
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 2217423609  27 TPSQSEALRACFERNPYPGIATRERLAQAIGIPEPRVQIWFQNERSRQ 74
Cdd:pfam00046   8 TPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKW 55
COG5576 COG5576
Homeodomain-containing transcription factor [Transcription];
86-148 1.65e-15

Homeodomain-containing transcription factor [Transcription];


Pssm-ID: 227863 [Multi-domain]  Cd Length: 156  Bit Score: 73.62  E-value: 1.65e-15
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2217423609  86 PGRRGPPEGRRKRTavTGSQTALLLRAFEKDRFPGIAAREELARETGLPESRIQIWFQNRRAR 148
Cdd:COG5576    45 QDGSSPPKSKRRRT--TDEQLMVLEREFEINPYPSSITRIKLSLLLNMPPKSVQIWFQNKRAK 105
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 25-74 5.15e-15

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 68.82  E-value: 5.15e-15
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 2217423609   25 VWTPSQSEALRACFERNPYPGIATRERLAQAIGIPEPRVQIWFQNERSRQ 74
Cdd:smart00389   7 SFTPEQLEELEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQNRRAKW 56
COG5576 COG5576
Homeodomain-containing transcription factor [Transcription];
30-102 3.78e-12

Homeodomain-containing transcription factor [Transcription];


Pssm-ID: 227863 [Multi-domain]  Cd Length: 156  Bit Score: 63.99  E-value: 3.78e-12
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2217423609  30 QSEALRACFERNPYPGIATRERLAQAIGIPEPRVQIWFQNERSRqLRQHRRESRpwpGRRGPPEGRRKRTAVT 102
Cdd:COG5576    62 QLMVLEREFEINPYPSSITRIKLSLLLNMPPKSVQIWFQNKRAK-EKKKRSGKV---EQRPGEEEADLAKIGS 130
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 141-319 5.05e-06

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 48.83  E-value: 5.05e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217423609 141 WFQNRRARHPGQGGRAPAQAGglcsAAPGGGHPAPSwvAFAHTGAWGTGLPAPHVPCAPGALPQGAFVSQAARAAPALQP 220
Cdd:PRK07764  606 SGPPEEAARPAAPAAPAAPAA----PAPAGAAAAPA--EASAAPAPGVAAPEHHPKHVAVPDASDGGDGWPAKAGGAAPA 679

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217423609 221 SQAAPAEGISQPAPARGDFAYAAPAPPDGALSHPQAPRWPPHPGKSREDRDPQRDGLPGPCAVAQPGPAQAGPQGQGVLA 300
Cdd:PRK07764  680 APPPAPAPAAPAAPAGAAPAQPAPAPAATPPAGQADDPAAQPPQAAQGASAPSPAADDPVPLPPEPDDPPDPAGAPAQPP 759

                         170
                  ....*....|....*....
gi 2217423609 301 PPTSQGSPwWGWGRGPQVA 319
Cdd:PRK07764  760 PPPAPAPA-AAPAAAPPPS 777
SPS1 COG0515
Serine/threonine protein kinase [Signal transduction mechanisms];
91-324 1.98e-03

Serine/threonine protein kinase [Signal transduction mechanisms];


Pssm-ID: 440281 [Multi-domain]  Cd Length: 482  Bit Score: 40.38  E-value: 1.98e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217423609  91 PPEGRRKRTAVTGSQTALLLRAFEKD---RFPG----IAAREELARETGLPESRIQIWFQNRRARHPGQGGRAPAQAGGL 163
Cdd:COG0515   225 PPPPSELRPDLPPALDAIVLRALAKDpeeRYQSaaelAAALRAVLRSLAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA 304

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217423609 164 CSAAPGGGHPAPSWVAFAHTGAWGTGLPAPHVPCAPGALPQGAFVSQAARAAPALQPSQAAPAEGISQPAPARGDFAYAA 243
Cdd:COG0515   305 AAAAAAAAAAAAAAAAAAPAAAAAAAAAAAALAAAAAAAAAAAAAALLAAAAALAAAAAAAAAAAAAAAAAAAAAAAAAA 384

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217423609 244 PAPPDGALSHPQAPRWPPHPGKSREDRDPQRDGLPGPCAVAQPGPAQAGPQGQGVLAPPTSQGSPWWGWGRGPQVAGAAW 323
Cdd:COG0515   385 LAAAAAAAAAAAAAALAAAAAAAAAAAAAAAAAAALAAAAAAAAAAAAAAAAAAAAAARLLAAAAAAAAAAAAAPLLAAL 464


                  .
gi 2217423609 324 E 324
Cdd:COG0515   465 L 465
PAT1 pfam09770
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
 208-423 4.20e-03

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 39.63  E-value: 4.20e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217423609 208 VSQAARAAPALQPSQAAPAegISQPAPARGDF----------AYAAPAPPDGALSHPQAPRWPPHPgksredrdpqrdgl 277
Cdd:pfam09770 165 VAPKKAAAPAPAPQPAAQP--ASLPAPSRKMMsleeveaamrAQAKKPAQQPAPAPAQPPAAPPAQ-------------- 228

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217423609 278 pgpcavAQPGPAQAGPQGQGVLAPPTSQGSPWWGWGRGPQVAgAAWEPQAGAAPPPQPAPPDASASARQGQMQGIPAPSQ 357
Cdd:pfam09770 229 ------QAQQQQQFPPQIQQQQQPQQQPQQPQQHPGQGHPVT-ILQRPQSPQPDPAQPSIQPQAQQFHQQPPPVPVQPTQ 301

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2217423609 358 ALQEPAPWSALPCGLLLDELLASPEFLQQAQPLLETEAPGELEASEEAASLeAPLSEEEYRALLEE 423
Cdd:pfam09770 302 ILQNPNRLSAARVGYPQNPQPGVQPAPAHQAHRQQGSFGRQAPIITHPQQL-AQLSEEEKAAYLDE 366
 
Name Accession Description Interval E-value
Homeodomain pfam00046
Homeodomain;
95-149 3.33e-21

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 86.40  E-value: 3.33e-21
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2217423609  95 RRKRTAVTGSQTALLLRAFEKDRFPGIAAREELARETGLPESRIQIWFQNRRARH 149
Cdd:pfam00046   1 RRKRTTFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKW 55
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 95-149 2.30e-19

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 81.14  E-value: 2.30e-19
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2217423609  95 RRKRTAVTGSQTALLLRAFEKDRFPGIAAREELARETGLPESRIQIWFQNRRARH 149
Cdd:cd00086     1 RRKRTRFTPEQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRAKL 55
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 94-149 2.36e-19

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 81.14  E-value: 2.36e-19
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 2217423609   94 GRRKRTAVTGSQTALLLRAFEKDRFPGIAAREELARETGLPESRIQIWFQNRRARH 149
Cdd:smart00389   1 KRRKRTSFTPEQLEELEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQNRRAKW 56
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 25-78 5.92e-17

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 74.59  E-value: 5.92e-17
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2217423609  25 VWTPSQSEALRACFERNPYPGIATRERLAQAIGIPEPRVQIWFQNERSRQLRQH 78
Cdd:cd00086     6 RFTPEQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRAKLKRSE 59
Homeodomain pfam00046
Homeodomain;
27-74 6.96e-16

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 71.38  E-value: 6.96e-16
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 2217423609  27 TPSQSEALRACFERNPYPGIATRERLAQAIGIPEPRVQIWFQNERSRQ 74
Cdd:pfam00046   8 TPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKW 55
COG5576 COG5576
Homeodomain-containing transcription factor [Transcription];
86-148 1.65e-15

Homeodomain-containing transcription factor [Transcription];


Pssm-ID: 227863 [Multi-domain]  Cd Length: 156  Bit Score: 73.62  E-value: 1.65e-15
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2217423609  86 PGRRGPPEGRRKRTavTGSQTALLLRAFEKDRFPGIAAREELARETGLPESRIQIWFQNRRAR 148
Cdd:COG5576    45 QDGSSPPKSKRRRT--TDEQLMVLEREFEINPYPSSITRIKLSLLLNMPPKSVQIWFQNKRAK 105
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 25-74 5.15e-15

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 68.82  E-value: 5.15e-15
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 2217423609   25 VWTPSQSEALRACFERNPYPGIATRERLAQAIGIPEPRVQIWFQNERSRQ 74
Cdd:smart00389   7 SFTPEQLEELEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQNRRAKW 56
COG5576 COG5576
Homeodomain-containing transcription factor [Transcription];
30-102 3.78e-12

Homeodomain-containing transcription factor [Transcription];


Pssm-ID: 227863 [Multi-domain]  Cd Length: 156  Bit Score: 63.99  E-value: 3.78e-12
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2217423609  30 QSEALRACFERNPYPGIATRERLAQAIGIPEPRVQIWFQNERSRqLRQHRRESRpwpGRRGPPEGRRKRTAVT 102
Cdd:COG5576    62 QLMVLEREFEINPYPSSITRIKLSLLLNMPPKSVQIWFQNKRAK-EKKKRSGKV---EQRPGEEEADLAKIGS 130
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 141-319 5.05e-06

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 48.83  E-value: 5.05e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217423609 141 WFQNRRARHPGQGGRAPAQAGglcsAAPGGGHPAPSwvAFAHTGAWGTGLPAPHVPCAPGALPQGAFVSQAARAAPALQP 220
Cdd:PRK07764  606 SGPPEEAARPAAPAAPAAPAA----PAPAGAAAAPA--EASAAPAPGVAAPEHHPKHVAVPDASDGGDGWPAKAGGAAPA 679

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217423609 221 SQAAPAEGISQPAPARGDFAYAAPAPPDGALSHPQAPRWPPHPGKSREDRDPQRDGLPGPCAVAQPGPAQAGPQGQGVLA 300
Cdd:PRK07764  680 APPPAPAPAAPAAPAGAAPAQPAPAPAATPPAGQADDPAAQPPQAAQGASAPSPAADDPVPLPPEPDDPPDPAGAPAQPP 759

                         170
                  ....*....|....*....
gi 2217423609 301 PPTSQGSPwWGWGRGPQVA 319
Cdd:PRK07764  760 PPPAPAPA-AAPAAAPPPS 777
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 201-322 7.23e-05

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 44.98  E-value: 7.23e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217423609 201 ALPQGAFVSQAARAAPALQPSQAAPAEGisqPAPARGDFAYAAPAPPDGALSHPQAPRWPPHPGKSREDRDPQRDGLPGP 280
Cdd:PRK07764  380 RLERRLGVAGGAGAPAAAAPSAAAAAPA---AAPAPAAAAPAAAAAPAPAAAPQPAPAPAPAPAPPSPAGNAPAGGAPSP 456

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 2217423609 281 CAVAQPgPAQAGPQGQGVLAPPTSQGSPWWGWGRGPQVAGAA 322
Cdd:PRK07764  457 PPAAAP-SAQPAPAPAAAPEPTAAPAPAPPAAPAPAAAPAAP 497
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 145-274 3.29e-04

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 43.05  E-value: 3.29e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217423609 145 RRARHPGQGGRAPAQAGGLCSAAPGGGHPAPSWVAFAHTGAWGTGLPAPHVPCAPGALPQGAFVSQAARAAPALQPSQAA 224
Cdd:PRK07764  383 RRLGVAGGAGAPAAAAPSAAAAAPAAAPAPAAAAPAAAAAPAPAAAPQPAPAPAPAPAPPSPAGNAPAGGAPSPPPAAAP 462

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2217423609 225 PAEGISQPAPARGDFAYAAPAPPDGALS--HPQAPRWPPHPGKSREDRDPQR 274
Cdd:PRK07764  463 SAQPAPAPAAAPEPTAAPAPAPPAAPAPaaAPAAPAAPAAPAGADDAATLRE 514
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
155-347 5.59e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 42.17  E-value: 5.59e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217423609 155 RAPAQAGGLCSAAPGGGHPAPSWVAFAHTGAWGTGLPAPhvpcAPGALPqGAFVSQAARAAPALQPSQAAPAEGISQPAP 234
Cdd:PRK12323  390 AAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSP----APEALA-AARQASARGPGGAPAPAPAPAAAPAAAARP 464

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217423609 235 argdfAYAAPAPPDGALSHPQAPRWPPHPGKSREDRDPQRDGLPGPCAVAQPGPAQAGPQGQGVLAPPTSQGSPWWGWGR 314
Cdd:PRK12323  465 -----AAAGPRPVAAAAAAAPARAAPAAAPAPADDDPPPWEELPPEFASPAPAQPDAAPAGWVAESIPDPATADPDDAFE 539

                         170       180       190
                  ....*....|....*....|....*....|...
gi 2217423609 315 GPQVAGAAWEPQAGAAPPPQPAPPDASASARQG 347
Cdd:PRK12323  540 TLAPAPAAAPAPRAAAATEPVVAPRPPRASASG 572
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 191-311 6.35e-04

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 42.01  E-value: 6.35e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217423609 191 PAPHVPCAPGALPQGAFVSQAARAAPALQPSQAAPAEGISQPAPARGDFAYAAPAPPDGALSHPQAPRWPPHPGKSREDR 270
Cdd:PRK14951  381 PARPEAAAPAAAPVAQAAAAPAPAAAPAAAASAPAAPPAAAPPAPVAAPAAAAPAAAPAAAPAAVALAPAPPAQAAPETV 460

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 2217423609 271 DPQRDGLPGPcAVAQPGPAQAgPQGQGVLAPPTSQGSPWWG 311
Cdd:PRK14951  461 AIPVRVAPEP-AVASAAPAPA-AAPAAARLTPTEEGDVWHA 499
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 209-411 6.74e-04

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 41.90  E-value: 6.74e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217423609 209 SQAARAAPALQPSQAAPAEGISQPAPARgdfAYAAPAPPDGALSHPQAPRWPPHPGKSREDRDPQRDGLPGPCAVAQPGP 288
Cdd:PRK07764  592 PGAAGGEGPPAPASSGPPEEAARPAAPA---APAAPAAPAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDASDGGDG 668

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217423609 289 AQAGPQGQGVLAPPTSQGSPWWGWGRGPQVAGAAWEPQAGAAPPPQPAPPDASASARQGQMQGIPAPSQALQEPAPWSAL 368
Cdd:PRK07764  669 WPAKAGGAAPAAPPPAPAPAAPAAPAGAAPAQPAPAPAATPPAGQADDPAAQPPQAAQGASAPSPAADDPVPLPPEPDDP 748

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 2217423609 369 PCGLLLDELLASPEFLQQAQPLLETEAPGELEASEEAASLEAP 411
Cdd:PRK07764  749 PDPAGAPAQPPPPPAPAPAAAPAAAPPPSPPSEEEEMAEDDAP 791
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
150-372 1.38e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 41.01  E-value: 1.38e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217423609 150 PGQGGRAPAQAGGLCSAAPGGGHPAPSWVAFAHTGAWGTGLPAPHVPCAPGALPQGAFVSQAARAAPALQPSQAAPAEGI 229
Cdd:PRK12323  374 PATAAAAPVAQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAARQASARGPGGAPAPAPA 453

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217423609 230 SQPAPARGDF-AYAAPAPPDGALSHPQAPRWPPHPGKSREDRDPQRDGLPGPCAVAQPGPAQAGPQGQGVLAPPTSQGSp 308
Cdd:PRK12323  454 PAAAPAAAARpAAAGPRPVAAAAAAAPARAAPAAAPAPADDDPPPWEELPPEFASPAPAQPDAAPAGWVAESIPDPATA- 532

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2217423609 309 wwgwgrgpQVAGAAWEPQAGAAPPPQPAPPDASASARQGQMQGIPAPSQALQEPAPWSALPCGL 372
Cdd:PRK12323  533 --------DPDDAFETLAPAPAAAPAPRAAAATEPVVAPRPPRASASGLPDMFDGDWPALAARL 588
SPS1 COG0515
Serine/threonine protein kinase [Signal transduction mechanisms];
91-324 1.98e-03

Serine/threonine protein kinase [Signal transduction mechanisms];


Pssm-ID: 440281 [Multi-domain]  Cd Length: 482  Bit Score: 40.38  E-value: 1.98e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217423609  91 PPEGRRKRTAVTGSQTALLLRAFEKD---RFPG----IAAREELARETGLPESRIQIWFQNRRARHPGQGGRAPAQAGGL 163
Cdd:COG0515   225 PPPPSELRPDLPPALDAIVLRALAKDpeeRYQSaaelAAALRAVLRSLAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA 304

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217423609 164 CSAAPGGGHPAPSWVAFAHTGAWGTGLPAPHVPCAPGALPQGAFVSQAARAAPALQPSQAAPAEGISQPAPARGDFAYAA 243
Cdd:COG0515   305 AAAAAAAAAAAAAAAAAAPAAAAAAAAAAAALAAAAAAAAAAAAAALLAAAAALAAAAAAAAAAAAAAAAAAAAAAAAAA 384

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217423609 244 PAPPDGALSHPQAPRWPPHPGKSREDRDPQRDGLPGPCAVAQPGPAQAGPQGQGVLAPPTSQGSPWWGWGRGPQVAGAAW 323
Cdd:COG0515   385 LAAAAAAAAAAAAAALAAAAAAAAAAAAAAAAAAALAAAAAAAAAAAAAAAAAAAAAARLLAAAAAAAAAAAAAPLLAAL 464


                  .
gi 2217423609 324 E 324
Cdd:COG0515   465 L 465
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
156-369 2.37e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 40.22  E-value: 2.37e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217423609 156 APAQAGGlcsAAPGGGHPAPswvafahtgawgtglpaphvpcAPGALPQGafvsqAARAAPALQPSQAAPAEGISQPAPA 235
Cdd:PRK07003  359 EPAVTGG---GAPGGGVPAR----------------------VAGAVPAP-----GARAAAAVGASAVPAVTAVTGAAGA 408

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217423609 236 RGDFAYAAPAPPDGALSHPQAPRwPPHPGKSREDRDPQRDGLPGPCAVAQPGPAQAGPQGQGVLAPPTSQGSPWwgwgrG 315
Cdd:PRK07003  409 ALAPKAAAAAAATRAEAPPAAPA-PPATADRGDDAADGDAPVPAKANARASADSRCDERDAQPPADSGSASAPA-----S 482

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2217423609 316 PQVAGAAWEPQAGAAPPPQPAPPDASASARQGQMQGIPAPSqALQEPAPWSALP 369
Cdd:PRK07003  483 DAPPDAAFEPAPRAAAPSAATPAAVPDARAPAAASREDAPA-AAAPPAPEARPP 535
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 191-369 2.81e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 39.97  E-value: 2.81e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217423609 191 PAPHVPCAPGALPQGAFVSQAARAAPALQPSQAAPAEGISQPAPARGDFAYAAPAPPDGALSHPQAPRWPPHPGKSREDR 270
Cdd:PRK07764  590 PAPGAAGGEGPPAPASSGPPEEAARPAAPAAPAAPAAPAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDASDGGDGW 669

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217423609 271 dPQRDGLPGPCAVAQPGPAQAGPQGQGVLAPPTSQGSPW--------WGWGRGPQVAGAAWEPQAGAAPPPqPAPPDASA 342
Cdd:PRK07764  670 -PAKAGGAAPAAPPPAPAPAAPAAPAGAAPAQPAPAPAAtppagqadDPAAQPPQAAQGASAPSPAADDPV-PLPPEPDD 747

                         170       180
                  ....*....|....*....|....*..
gi 2217423609 343 SARQGQMQGIPAPSQALQEPAPWSALP 369
Cdd:PRK07764  748 PPDPAGAPAQPPPPPAPAPAAAPAAAP 774
Homeobox_KN pfam05920
Homeobox KN domain; This is a homeobox transcription factor KN domain conserved from fungi to ...
 124-148 3.00e-03

Homeobox KN domain; This is a homeobox transcription factor KN domain conserved from fungi to human and plants. They were first identified as TALE homeobox genes in eukaryotes, (including KNOX and MEIS genes). They have been recently classified.


Pssm-ID: 428673  Cd Length: 39  Bit Score: 35.18  E-value: 3.00e-03
                          10        20
                  ....*....|....*....|....*
gi 2217423609 124 REELARETGLPESRIQIWFQNRRAR 148
Cdd:pfam05920  15 KAELAKETGLSRKQISNWFINARRR 39
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
200-398 3.76e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 39.47  E-value: 3.76e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217423609 200 GALPQGAFVSQAARAAPALQPSQAAPAEGISQPAPARGDFAYAAPAPPDGALSHPQAP-RWPPHPGKSREDRDPQRDGLP 278
Cdd:PRK12323  371 GAGPATAAAAPVAQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPaPEALAAARQASARGPGGAPAP 450

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217423609 279 GPCAVAQPGPAQAgPQGQGVLAPPTSQGSPWWGWGRGPQVAGAA-----WEPQAGAAPPPQPAPPDASASARQGQMQGIP 353
Cdd:PRK12323  451 APAPAAAPAAAAR-PAAAGPRPVAAAAAAAPARAAPAAAPAPADddpppWEELPPEFASPAPAQPDAAPAGWVAESIPDP 529

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2217423609 354 APSQ------ALQEPAPWSALPCGLLLDELLASPEFLQQAQPLLETEAPGE 398
Cdd:PRK12323  530 ATADpddafeTLAPAPAAAPAPRAAAATEPVVAPRPPRASASGLPDMFDGD 580
PAT1 pfam09770
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
 208-423 4.20e-03

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 39.63  E-value: 4.20e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217423609 208 VSQAARAAPALQPSQAAPAegISQPAPARGDF----------AYAAPAPPDGALSHPQAPRWPPHPgksredrdpqrdgl 277
Cdd:pfam09770 165 VAPKKAAAPAPAPQPAAQP--ASLPAPSRKMMsleeveaamrAQAKKPAQQPAPAPAQPPAAPPAQ-------------- 228

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217423609 278 pgpcavAQPGPAQAGPQGQGVLAPPTSQGSPWWGWGRGPQVAgAAWEPQAGAAPPPQPAPPDASASARQGQMQGIPAPSQ 357
Cdd:pfam09770 229 ------QAQQQQQFPPQIQQQQQPQQQPQQPQQHPGQGHPVT-ILQRPQSPQPDPAQPSIQPQAQQFHQQPPPVPVQPTQ 301

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2217423609 358 ALQEPAPWSALPCGLLLDELLASPEFLQQAQPLLETEAPGELEASEEAASLeAPLSEEEYRALLEE 423
Cdd:pfam09770 302 ILQNPNRLSAARVGYPQNPQPGVQPAPAHQAHRQQGSFGRQAPIITHPQQL-AQLSEEEKAAYLDE 366
PHA03247 PHA03247
large tegument protein UL36; Provisional
 91-414 4.51e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 39.54  E-value: 4.51e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217423609   91 PPEGRRKRTAVTGSQTALLLRAFEKDRFPGIAAREELARETGLPEsriqiwfQNRRARHPGQGGRAPAQAGGLCSAAPGG 170
Cdd:PHA03247  2627 PPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLG-------RAAQASSPPQRPRRRAARPTVGSLTSLA 2699

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217423609  171 GHPAPSWVAFAHTGAWGTGLPAPHVPCAPGALPQGAFVSQAARAAPALQPSQAAPAEGISQPAPArgdfAYAAPAPPDGA 250
Cdd:PHA03247  2700 DPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTA----GPPAPAPPAAP 2775

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217423609  251 LSHPQaPRWPPHPGKS----REDRDPQRDGLPGPCAVAQPGPAQAGPQGQGVLAPPTSQGSP------------WWGWGR 314
Cdd:PHA03247  2776 AAGPP-RRLTRPAVASlsesRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPtapppppgppppSLPLGG 2854

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217423609  315 GPQVAGAAWEPQAGAAPPPQPAPPDASASARQGQMQGIPAPSQALQEPAPWSALPCGLLLDELLASPEFLQQAQPLLETE 394
Cdd:PHA03247  2855 SVAPGGDVRRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPP 2934

                          330       340
                   ....*....|....*....|
gi 2217423609  395 APGELEASEEAASLEAPLSE 414
Cdd:PHA03247  2935 PPPRPQPPLAPTTDPAGAGE 2954
PRK14959 PRK14959
DNA polymerase III subunits gamma and tau; Provisional
 165-265 6.74e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 184923 [Multi-domain]  Cd Length: 624  Bit Score: 38.89  E-value: 6.74e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217423609 165 SAAPGGGHPAPswvafahtgAWGTGLPAPHVPCAPGALPQGAFVSQAARAAPALQPSQAAPAEGISQPAPA-RGDFAYAA 243
Cdd:PRK14959  370 SLRPSGGGASA---------PSGSAAEGPASGGAATIPTPGTQGPQGTAPAAGMTPSSAAPATPAPSAAPSpRVPWDDAP 440

                          90       100
                  ....*....|....*....|....*
gi 2217423609 244 PAPPDGALSHPQAPRWP---PHPGK 265
Cdd:PRK14959  441 PAPPRSGIPPRPAPRMPeasPVPGA 465
Homeobox_KN pfam05920
Homeobox KN domain; This is a homeobox transcription factor KN domain conserved from fungi to ...
 41-73 6.74e-03

Homeobox KN domain; This is a homeobox transcription factor KN domain conserved from fungi to human and plants. They were first identified as TALE homeobox genes in eukaryotes, (including KNOX and MEIS genes). They have been recently classified.


Pssm-ID: 428673  Cd Length: 39  Bit Score: 34.41  E-value: 6.74e-03
                          10        20        30
                  ....*....|....*....|....*....|...
gi 2217423609  41 NPYPGIATRERLAQAIGIPEPRVQIWFQNERSR 73
Cdd:pfam05920   7 NPYPSEEEKAELAKETGLSRKQISNWFINARRR 39
kgd PRK12270
multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine ...
 175-274 7.64e-03

multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit;


Pssm-ID: 237030 [Multi-domain]  Cd Length: 1228  Bit Score: 38.72  E-value: 7.64e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217423609  175 PSWVA-FAHTGAWGTGLPAPHVPCAPGALPQGAFVSQAARAAPAlQPSQAAPAEGISQPAPARgdfAYAAPAPPDGALSH 253
Cdd:PRK12270    27 PSWREfFADYGPGSTAAPTAAAAAAAAAASAPAAAPAAKAPAAP-APAPPAAAAPAAPPKPAA---AAAAAAAPAAPPAA 102

                           90       100
                   ....*....|....*....|.
gi 2217423609  254 PQAPrwPPHPGKSREDRDPQR 274
Cdd:PRK12270   103 AAAA--APAAAAVEDEVTPLR 121
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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