NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|2217328693|ref|XP_047300644|]
View 

dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform X4 [Homo sapiens]

Protein Classification

calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1( domain architecture ID 10763433)

calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1 (PDE1) is a cyclic nucleotide phosphodiesterase with a dual specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
PDEase_I pfam00233
3'5'-cyclic nucleotide phosphodiesterase;
246-467 1.85e-108

3'5'-cyclic nucleotide phosphodiesterase;


:

Pssm-ID: 459723  Cd Length: 238  Bit Score: 324.50  E-value: 1.85e-108
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217328693 246 YHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAY 325
Cdd:pfam00233   1 YHNWRHAFDVTQTMYYLLKTGKLKEVLTDLEILALLIAALCHDVDHPGTNNAFLIKTKSPLAILYNDSSVLENHHCATAF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217328693 326 RLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKT--------MSLILHAADISH 397
Cdd:pfam00233  81 QILQDEECNIFSNLSDEEYKEVRKLIISLILATDMAKHFELLKKFKSLLESKKTLDFLENeedrrlllLSMLIKAADISN 160

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2217328693 398 PAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDR-KSTMVAQSQIGFIDFIVEPTFSLLTDSTEKI 467
Cdd:pfam00233 161 PTRPWEISKKWADLVAEEFFRQGDLEKELGLPVSPLMDReKKTSLPKSQIGFIDFIVLPLFEALAKLFPEL 231
PDEase_I_N pfam08499
3'5'-cyclic nucleotide phosphodiesterase N-terminal; This domain is found to the N-terminus of ...
 101-161 2.15e-29

3'5'-cyclic nucleotide phosphodiesterase N-terminal; This domain is found to the N-terminus of the calcium/calmodulin-dependent 3'5'-cyclic nucleotide phosphodiesterase domain (pfam00233).


:

Pssm-ID: 462497 [Multi-domain]  Cd Length: 61  Bit Score: 110.12  E-value: 2.15e-29
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2217328693 101 RLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVER 161
Cdd:pfam08499   1 RLLDEEDELSEIQSDAVPSEVRDWLASTFTRQMAAHKRRSEEKPKFRSVAHAVQAGIFVER 61
 
Name Accession Description Interval E-value
PDEase_I pfam00233
3'5'-cyclic nucleotide phosphodiesterase;
246-467 1.85e-108

3'5'-cyclic nucleotide phosphodiesterase;


Pssm-ID: 459723  Cd Length: 238  Bit Score: 324.50  E-value: 1.85e-108
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217328693 246 YHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAY 325
Cdd:pfam00233   1 YHNWRHAFDVTQTMYYLLKTGKLKEVLTDLEILALLIAALCHDVDHPGTNNAFLIKTKSPLAILYNDSSVLENHHCATAF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217328693 326 RLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKT--------MSLILHAADISH 397
Cdd:pfam00233  81 QILQDEECNIFSNLSDEEYKEVRKLIISLILATDMAKHFELLKKFKSLLESKKTLDFLENeedrrlllLSMLIKAADISN 160

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2217328693 398 PAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDR-KSTMVAQSQIGFIDFIVEPTFSLLTDSTEKI 467
Cdd:pfam00233 161 PTRPWEISKKWADLVAEEFFRQGDLEKELGLPVSPLMDReKKTSLPKSQIGFIDFIVLPLFEALAKLFPEL 231
PDEase_I_N pfam08499
3'5'-cyclic nucleotide phosphodiesterase N-terminal; This domain is found to the N-terminus of ...
 101-161 2.15e-29

3'5'-cyclic nucleotide phosphodiesterase N-terminal; This domain is found to the N-terminus of the calcium/calmodulin-dependent 3'5'-cyclic nucleotide phosphodiesterase domain (pfam00233).


Pssm-ID: 462497 [Multi-domain]  Cd Length: 61  Bit Score: 110.12  E-value: 2.15e-29
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2217328693 101 RLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVER 161
Cdd:pfam08499   1 RLLDEEDELSEIQSDAVPSEVRDWLASTFTRQMAAHKRRSEEKPKFRSVAHAVQAGIFVER 61
HDc cd00077
Metal dependent phosphohydrolases with conserved 'HD' motif
 246-417 9.99e-13

Metal dependent phosphohydrolases with conserved 'HD' motif


Pssm-ID: 238032 [Multi-domain]  Cd Length: 145  Bit Score: 65.82  E-value: 9.99e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217328693 246 YHNLIHAADVTQTVHYIMLHTGimhwLTELEILAMVFAAAIHDYEHTGTTNNFhiqtrsdvailYNDRSVLENHHVSAAY 325
Cdd:cd00077     1 EHRFEHSLRVAQLARRLAEELG----LSEEDIELLRLAALLHDIGKPGTPDAI-----------TEEESELEKDHAIVGA 65

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217328693 326 RLmqeeemnilinLSKDDWRDLRNLVIEMVLSTDMSgHFQQIKniRNSLQQPEGIDRAKTMSLILHAADISHPAK--SWK 403
Cdd:cd00077    66 EI-----------LRELLLEEVIKLIDELILAVDAS-HHERLD--GLGYPDGLKGEEITLEARIVKLADRLDALRrdSRE 131

                         170
                  ....*....|....
gi 2217328693 404 LHYRWTMALMEEFF 417
Cdd:cd00077   132 KRRRIAEEDLEELL 145
HDc smart00471
Metal dependent phosphohydrolases with conserved 'HD' motif; Includes eukaryotic cyclic ...
 244-408 2.66e-11

Metal dependent phosphohydrolases with conserved 'HD' motif; Includes eukaryotic cyclic nucleotide phosphodiesterases (PDEc). This profile/HMM does not detect HD homologues in bacterial glycine aminoacyl-tRNA synthetases (beta subunit).


Pssm-ID: 214679 [Multi-domain]  Cd Length: 124  Bit Score: 61.16  E-value: 2.66e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217328693  244 NPYHNLIHAADVTQTVHYIMLHTGimhwltELEILAMVFAAAIHDYEHTGTTNNFHIQTrsdvailyndrSVLENHHVSA 323
Cdd:smart00471   1 SDYHVFEHSLRVAQLAAALAEELG------LLDIELLLLAALLHDIGKPGTPDSFLVKT-----------SVLEDHHFIG 63

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217328693  324 AYRLMQEEEMNILINLskddwrdlrnlviemvLSTDMSGHFQQIKnirnslqqPEGIDRAKTMSLILHAADISHPAKSWK 403
Cdd:smart00471  64 AEILLEEEEPRILEEI----------------LRTAILSHHERPD--------GLRGEPITLEARIVKVADRLDALRADR 119


                   ....*
gi 2217328693  404 LHYRW 408
Cdd:smart00471 120 RYRRV 124
 
Name Accession Description Interval E-value
PDEase_I pfam00233
3'5'-cyclic nucleotide phosphodiesterase;
246-467 1.85e-108

3'5'-cyclic nucleotide phosphodiesterase;


Pssm-ID: 459723  Cd Length: 238  Bit Score: 324.50  E-value: 1.85e-108
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217328693 246 YHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAY 325
Cdd:pfam00233   1 YHNWRHAFDVTQTMYYLLKTGKLKEVLTDLEILALLIAALCHDVDHPGTNNAFLIKTKSPLAILYNDSSVLENHHCATAF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217328693 326 RLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKT--------MSLILHAADISH 397
Cdd:pfam00233  81 QILQDEECNIFSNLSDEEYKEVRKLIISLILATDMAKHFELLKKFKSLLESKKTLDFLENeedrrlllLSMLIKAADISN 160

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2217328693 398 PAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDR-KSTMVAQSQIGFIDFIVEPTFSLLTDSTEKI 467
Cdd:pfam00233 161 PTRPWEISKKWADLVAEEFFRQGDLEKELGLPVSPLMDReKKTSLPKSQIGFIDFIVLPLFEALAKLFPEL 231
PDEase_I_N pfam08499
3'5'-cyclic nucleotide phosphodiesterase N-terminal; This domain is found to the N-terminus of ...
 101-161 2.15e-29

3'5'-cyclic nucleotide phosphodiesterase N-terminal; This domain is found to the N-terminus of the calcium/calmodulin-dependent 3'5'-cyclic nucleotide phosphodiesterase domain (pfam00233).


Pssm-ID: 462497 [Multi-domain]  Cd Length: 61  Bit Score: 110.12  E-value: 2.15e-29
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2217328693 101 RLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVER 161
Cdd:pfam08499   1 RLLDEEDELSEIQSDAVPSEVRDWLASTFTRQMAAHKRRSEEKPKFRSVAHAVQAGIFVER 61
HDc cd00077
Metal dependent phosphohydrolases with conserved 'HD' motif
 246-417 9.99e-13

Metal dependent phosphohydrolases with conserved 'HD' motif


Pssm-ID: 238032 [Multi-domain]  Cd Length: 145  Bit Score: 65.82  E-value: 9.99e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217328693 246 YHNLIHAADVTQTVHYIMLHTGimhwLTELEILAMVFAAAIHDYEHTGTTNNFhiqtrsdvailYNDRSVLENHHVSAAY 325
Cdd:cd00077     1 EHRFEHSLRVAQLARRLAEELG----LSEEDIELLRLAALLHDIGKPGTPDAI-----------TEEESELEKDHAIVGA 65

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217328693 326 RLmqeeemnilinLSKDDWRDLRNLVIEMVLSTDMSgHFQQIKniRNSLQQPEGIDRAKTMSLILHAADISHPAK--SWK 403
Cdd:cd00077    66 EI-----------LRELLLEEVIKLIDELILAVDAS-HHERLD--GLGYPDGLKGEEITLEARIVKLADRLDALRrdSRE 131

                         170
                  ....*....|....
gi 2217328693 404 LHYRWTMALMEEFF 417
Cdd:cd00077   132 KRRRIAEEDLEELL 145
HDc smart00471
Metal dependent phosphohydrolases with conserved 'HD' motif; Includes eukaryotic cyclic ...
 244-408 2.66e-11

Metal dependent phosphohydrolases with conserved 'HD' motif; Includes eukaryotic cyclic nucleotide phosphodiesterases (PDEc). This profile/HMM does not detect HD homologues in bacterial glycine aminoacyl-tRNA synthetases (beta subunit).


Pssm-ID: 214679 [Multi-domain]  Cd Length: 124  Bit Score: 61.16  E-value: 2.66e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217328693  244 NPYHNLIHAADVTQTVHYIMLHTGimhwltELEILAMVFAAAIHDYEHTGTTNNFHIQTrsdvailyndrSVLENHHVSA 323
Cdd:smart00471   1 SDYHVFEHSLRVAQLAAALAEELG------LLDIELLLLAALLHDIGKPGTPDSFLVKT-----------SVLEDHHFIG 63

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217328693  324 AYRLMQEEEMNILINLskddwrdlrnlviemvLSTDMSGHFQQIKnirnslqqPEGIDRAKTMSLILHAADISHPAKSWK 403
Cdd:smart00471  64 AEILLEEEEPRILEEI----------------LRTAILSHHERPD--------GLRGEPITLEARIVKVADRLDALRADR 119


                   ....*
gi 2217328693  404 LHYRW 408
Cdd:smart00471 120 RYRRV 124
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH