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Conserved domains on  [gi|2280259481|ref|XP_049668666|]
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WD repeat domain phosphoinositide-interacting protein 3 [Accipiter gentilis]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 13234759)

WD40 repeat domain-containing protein folds into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome; similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
Gene Ontology:  GO:0005515
PubMed:  10322433|8090199|30069656|29026209
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
152-264 6.34e-10

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 59.92  E-value: 6.34e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2280259481 152 NNSLLAFpGTHTGHVQIVDLAnTEKPPVDIPAHEGVLSCIALNLQGTRIATASEKGTlIRIFDTSSGHLIQELRRGSQAa 231
Cdd:COG2319   215 DGKLLAS-GSADGTVRLWDLA-TGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGT-VRLWDLATGELLRTLTGHSGG- 290

                          90       100       110
                  ....*....|....*....|....*....|...
gi 2280259481 232 nIYCINFNQDASLICVSSDHGTVHIFAAEDPKR 264
Cdd:COG2319   291 -VNSVAFSPDGKLLASGSDDGTVRLWDLATGKL 322
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 45-257 2.42e-09

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 57.34  E-value: 2.42e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2280259481  45 EKQEFLEGGVGHVEMLFRC------NYLALVGGGKKpkyppnkVMIWDDLKKKTVIEIE-FSTEVKAVKLRRDRIVVV-- 115
Cdd:cd00200    39 ETGELLRTLKGHTGPVRDVaasadgTYLASGSSDKT-------IRLWDLETGECVRTLTgHTSYVSSVAFSPDGRILSss 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2280259481 116 -LDSMIKVFTFTHNPhQLHVFETCynPKGLCVLCPNSNNSLLAFpGTHTGHVQIVDLaNTEKPPVDIPAHEGVLSCIALN 194
Cdd:cd00200   112 sRDKTIKVWDVETGK-CLTTLRGH--TDWVNSVAFSPDGTFVAS-SSQDGTIKLWDL-RTGKCVATLTGHTGEVNSVAFS 186

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2280259481 195 LQGTRIATASEKGTlIRIFDTSSGHLIQELRrgSQAANIYCINFNQDASLICVSSDHGTVHIF 257
Cdd:cd00200   187 PDGEKLLSSSSDGT-IKLWDLSTGKCLGTLR--GHENGVNSVAFSPDGYLLASGSEDGTIRVW 246
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
152-264 6.34e-10

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 59.92  E-value: 6.34e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2280259481 152 NNSLLAFpGTHTGHVQIVDLAnTEKPPVDIPAHEGVLSCIALNLQGTRIATASEKGTlIRIFDTSSGHLIQELRRGSQAa 231
Cdd:COG2319   215 DGKLLAS-GSADGTVRLWDLA-TGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGT-VRLWDLATGELLRTLTGHSGG- 290

                          90       100       110
                  ....*....|....*....|....*....|...
gi 2280259481 232 nIYCINFNQDASLICVSSDHGTVHIFAAEDPKR 264
Cdd:COG2319   291 -VNSVAFSPDGKLLASGSDDGTVRLWDLATGKL 322
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 45-257 2.42e-09

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 57.34  E-value: 2.42e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2280259481  45 EKQEFLEGGVGHVEMLFRC------NYLALVGGGKKpkyppnkVMIWDDLKKKTVIEIE-FSTEVKAVKLRRDRIVVV-- 115
Cdd:cd00200    39 ETGELLRTLKGHTGPVRDVaasadgTYLASGSSDKT-------IRLWDLETGECVRTLTgHTSYVSSVAFSPDGRILSss 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2280259481 116 -LDSMIKVFTFTHNPhQLHVFETCynPKGLCVLCPNSNNSLLAFpGTHTGHVQIVDLaNTEKPPVDIPAHEGVLSCIALN 194
Cdd:cd00200   112 sRDKTIKVWDVETGK-CLTTLRGH--TDWVNSVAFSPDGTFVAS-SSQDGTIKLWDL-RTGKCVATLTGHTGEVNSVAFS 186

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2280259481 195 LQGTRIATASEKGTlIRIFDTSSGHLIQELRrgSQAANIYCINFNQDASLICVSSDHGTVHIF 257
Cdd:cd00200   187 PDGEKLLSSSSDGT-IKLWDLSTGKCLGTLR--GHENGVNSVAFSPDGYLLASGSEDGTIRVW 246
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 141-263 3.73e-09

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 56.96  E-value: 3.73e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2280259481 141 PKGLCVLCPNSNNSLLAFpGTHTGHVQIVDLaNTEKPPVDIPAHEGVLSCIALNLQGTRIATASEKGTlIRIFDTSSGHL 220
Cdd:cd00200     9 TGGVTCVAFSPDGKLLAT-GSGDGTIKVWDL-ETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKT-IRLWDLETGEC 85

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 2280259481 221 IQELRrGSQAAnIYCINFNQDASLICVSSDHGTVHIFAAEDPK 263
Cdd:cd00200    86 VRTLT-GHTSY-VSSVAFSPDGRILSSSSRDKTIKVWDVETGK 126
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
152-264 6.34e-10

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 59.92  E-value: 6.34e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2280259481 152 NNSLLAFpGTHTGHVQIVDLAnTEKPPVDIPAHEGVLSCIALNLQGTRIATASEKGTlIRIFDTSSGHLIQELRRGSQAa 231
Cdd:COG2319   215 DGKLLAS-GSADGTVRLWDLA-TGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGT-VRLWDLATGELLRTLTGHSGG- 290

                          90       100       110
                  ....*....|....*....|....*....|...
gi 2280259481 232 nIYCINFNQDASLICVSSDHGTVHIFAAEDPKR 264
Cdd:COG2319   291 -VNSVAFSPDGKLLASGSDDGTVRLWDLATGKL 322
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 45-257 2.42e-09

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 57.34  E-value: 2.42e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2280259481  45 EKQEFLEGGVGHVEMLFRC------NYLALVGGGKKpkyppnkVMIWDDLKKKTVIEIE-FSTEVKAVKLRRDRIVVV-- 115
Cdd:cd00200    39 ETGELLRTLKGHTGPVRDVaasadgTYLASGSSDKT-------IRLWDLETGECVRTLTgHTSYVSSVAFSPDGRILSss 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2280259481 116 -LDSMIKVFTFTHNPhQLHVFETCynPKGLCVLCPNSNNSLLAFpGTHTGHVQIVDLaNTEKPPVDIPAHEGVLSCIALN 194
Cdd:cd00200   112 sRDKTIKVWDVETGK-CLTTLRGH--TDWVNSVAFSPDGTFVAS-SSQDGTIKLWDL-RTGKCVATLTGHTGEVNSVAFS 186

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2280259481 195 LQGTRIATASEKGTlIRIFDTSSGHLIQELRrgSQAANIYCINFNQDASLICVSSDHGTVHIF 257
Cdd:cd00200   187 PDGEKLLSSSSDGT-IKLWDLSTGKCLGTLR--GHENGVNSVAFSPDGYLLASGSEDGTIRVW 246
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 25-258 2.49e-09

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 57.34  E-value: 2.49e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2280259481  25 FACGMENGFRVYNADplKEKEKQEFleggVGHVEMLFRCNYLA----LVGGGKKpkyppNKVMIWDDLKKKTVIEIEFST 100
Cdd:cd00200    67 ASGSSDKTIRLWDLE--TGECVRTL----TGHTSYVSSVAFSPdgriLSSSSRD-----KTIKVWDVETGKCLTTLRGHT 135

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2280259481 101 E-VKAVKLRRDRIVVV---LDSMIKVF---------TFTHnpHQLHVFETCYNPKGLCVLCpnsnnsllafpGTHTGHVQ 167
Cdd:cd00200   136 DwVNSVAFSPDGTFVAsssQDGTIKLWdlrtgkcvaTLTG--HTGEVNSVAFSPDGEKLLS-----------SSSDGTIK 202

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2280259481 168 IVDLaNTEKPPVDIPAHEGVLSCIALNLQGTRIATASEKGTlIRIFDTSSGHLIQELRrGSQAAnIYCINFNQDASLICV 247
Cdd:cd00200   203 LWDL-STGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGT-IRVWDLRTGECVQTLS-GHTNS-VTSLAWSPDGKRLAS 278

                         250
                  ....*....|.
gi 2280259481 248 SSDHGTVHIFA 258
Cdd:cd00200   279 GSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
160-277 2.96e-09

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 58.00  E-value: 2.96e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2280259481 160 GTHTGHVQIVDLAnTEKPPVDIPAHEGVLSCIALNLQGTRIATASEKGTlIRIFDTSSGHLIQELRRGSQAanIYCINFN 239
Cdd:COG2319   180 GSDDGTVRLWDLA-TGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGT-VRLWDLATGKLLRTLTGHSGS--VRSVAFS 255

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 2280259481 240 QDASLICVSSDHGTVHIFAAEDPKRNK-----QSSLASASFLP 277
Cdd:COG2319   256 PDGRLLASGSADGTVRLWDLATGELLRtltghSGGVNSVAFSP 298
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 141-263 3.73e-09

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 56.96  E-value: 3.73e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2280259481 141 PKGLCVLCPNSNNSLLAFpGTHTGHVQIVDLaNTEKPPVDIPAHEGVLSCIALNLQGTRIATASEKGTlIRIFDTSSGHL 220
Cdd:cd00200     9 TGGVTCVAFSPDGKLLAT-GSGDGTIKVWDL-ETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKT-IRLWDLETGEC 85

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 2280259481 221 IQELRrGSQAAnIYCINFNQDASLICVSSDHGTVHIFAAEDPK 263
Cdd:cd00200    86 VRTLT-GHTSY-VSSVAFSPDGRILSSSSRDKTIKVWDVETGK 126
WD40 COG2319
WD40 repeat [General function prediction only];
152-261 3.47e-08

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 54.53  E-value: 3.47e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2280259481 152 NNSLLAFpGTHTGHVQIVDLAnTEKPPVDIPAHEGVLSCIALNLQGTRIATASEKGTlIRIFDTSSGHLIQELRRGSQAa 231
Cdd:COG2319   299 DGKLLAS-GSDDGTVRLWDLA-TGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGT-VRLWDLATGELLRTLTGHTGA- 374

                          90       100       110
                  ....*....|....*....|....*....|
gi 2280259481 232 nIYCINFNQDASLICVSSDHGTVHIFAAED 261
Cdd:COG2319   375 -VTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
160-277 4.11e-08

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 54.53  E-value: 4.11e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2280259481 160 GTHTGHVQIVDLAnTEKPPVDIPAHEGVLSCIALNLQGTRIATASEKGTlIRIFDTSSGHLIQELRRGSQAanIYCINFN 239
Cdd:COG2319    96 ASADGTVRLWDLA-TGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGT-VRLWDLATGKLLRTLTGHSGA--VTSVAFS 171

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 2280259481 240 QDASLICVSSDHGTVHIFAAEDPK-----RNKQSSLASASFLP 277
Cdd:COG2319   172 PDGKLLASGSDDGTVRLWDLATGKllrtlTGHTGAVRSVAFSP 214
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 117-316 2.71e-06

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 48.10  E-value: 2.71e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2280259481 117 DSMIKVFTFTHNpHQLHVFETCYNPKGLCVLCPNSNnSLLA--FPGThtghVQIVDLaNTEKPPVDIPAHEGVLSCIALN 194
Cdd:cd00200    30 DGTIKVWDLETG-ELLRTLKGHTGPVRDVAASADGT-YLASgsSDKT----IRLWDL-ETGECVRTLTGHTSYVSSVAFS 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2280259481 195 LQGTRIATASEKGTlIRIFDTSSGHLIQELRrgSQAANIYCINFNQDASLICVSSDHGTVHIFAAEDPKRNK-----QSS 269
Cdd:cd00200   103 PDGRILSSSSRDKT-IKVWDVETGKCLTTLR--GHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVAtltghTGE 179

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2280259481 270 LASASFLP---KYFSS-------KWSFSKFQvpsgspCICAFGTEPNAVIAICADGS 316
Cdd:cd00200   180 VNSVAFSPdgeKLLSSssdgtikLWDLSTGK------CLGTLRGHENGVNSVAFSPD 230
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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