NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|2462556247|ref|XP_054172569|]
View 

WD repeat domain phosphoinositide-interacting protein 1 isoform X1 [Homo sapiens]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
2-134 1.21e-11

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 64.93  E-value: 1.21e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462556247   2 KLLKTLldiPANPTGLCALSINHSNSYLAYpGSlTSGEIVLYDGNSLKTVCTIAAHEGTLAAITFNASGSKLASASEKGT 81
Cdd:COG2319   195 KLLRTL---TGHTGAVRSVAFSPDGKLLAS-GS-ADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGT 269

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2462556247  82 ViRVFSVPDGQKLYEFRRGMKRyvtISSLVFSMDSQFLCASSNTETVHIFKLE 134
Cdd:COG2319   270 V-RLWDLATGELLRTLTGHSGG---VNSVAFSPDGKLLASGSDDGTVRLWDLA 318
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
2-134 1.21e-11

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 64.93  E-value: 1.21e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462556247   2 KLLKTLldiPANPTGLCALSINHSNSYLAYpGSlTSGEIVLYDGNSLKTVCTIAAHEGTLAAITFNASGSKLASASEKGT 81
Cdd:COG2319   195 KLLRTL---TGHTGAVRSVAFSPDGKLLAS-GS-ADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGT 269

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2462556247  82 ViRVFSVPDGQKLYEFRRGMKRyvtISSLVFSMDSQFLCASSNTETVHIFKLE 134
Cdd:COG2319   270 V-RLWDLATGELLRTLTGHSGG---VNSVAFSPDGKLLASGSDDGTVRLWDLA 318
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 18-134 2.73e-11

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 63.12  E-value: 2.73e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462556247  18 CALSINHSNSYLAypGSLTSGEIVLYDGNSLKTVCTIAAHEGTLAAITFNASGSKLASASEKGTvIRVFSVPDGQKLYEF 97
Cdd:cd00200   139 NSVAFSPDGTFVA--SSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGT-IKLWDLSTGKCLGTL 215

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 2462556247  98 rRGMKRYVTisSLVFSMDSQFLCASSNTETVHIFKLE 134
Cdd:cd00200   216 -RGHENGVN--SVAFSPDGYLLASGSEDGTIRVWDLR 249
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 47-87 7.02e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 33.83  E-value: 7.02e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 2462556247   47 SLKTVCTIAAHEGTLAAITFNASGSKLASASEKGTvIRVFS 87
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGT-IKLWD 40
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
2-134 1.21e-11

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 64.93  E-value: 1.21e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462556247   2 KLLKTLldiPANPTGLCALSINHSNSYLAYpGSlTSGEIVLYDGNSLKTVCTIAAHEGTLAAITFNASGSKLASASEKGT 81
Cdd:COG2319   195 KLLRTL---TGHTGAVRSVAFSPDGKLLAS-GS-ADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGT 269

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2462556247  82 ViRVFSVPDGQKLYEFRRGMKRyvtISSLVFSMDSQFLCASSNTETVHIFKLE 134
Cdd:COG2319   270 V-RLWDLATGELLRTLTGHSGG---VNSVAFSPDGKLLASGSDDGTVRLWDLA 318
WD40 COG2319
WD40 repeat [General function prediction only];
19-229 2.47e-11

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 63.78  E-value: 2.47e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462556247  19 ALSINHSNSYLAYpGSlTSGEIVLYDGNSLKTVCTIAAHEGTLAAITFNASGSKLASASEKGTViRVFSVPDGQKLYEFR 98
Cdd:COG2319   125 SVAFSPDGKTLAS-GS-ADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTV-RLWDLATGKLLRTLT 201

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462556247  99 RGMKRyvtISSLVFSMDSQFLCASSNTETVHIFKLEqvtnsRPEEPSTWSGymgkmfmaatnylptqvsdmmHQDRAFAT 178
Cdd:COG2319   202 GHTGA---VRSVAFSPDGKLLASGSADGTVRLWDLA-----TGKLLRTLTG---------------------HSGSVRSV 252

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2462556247 179 ArlnFS--GQrnictlstiqklpRLLVASSSGHLYMYNLdpqDGGECVLIKTH 229
Cdd:COG2319   253 A---FSpdGR-------------LLASGSADGTVRLWDL---ATGELLRTLTG 286
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 18-134 2.73e-11

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 63.12  E-value: 2.73e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462556247  18 CALSINHSNSYLAypGSLTSGEIVLYDGNSLKTVCTIAAHEGTLAAITFNASGSKLASASEKGTvIRVFSVPDGQKLYEF 97
Cdd:cd00200   139 NSVAFSPDGTFVA--SSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGT-IKLWDLSTGKCLGTL 215

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 2462556247  98 rRGMKRYVTisSLVFSMDSQFLCASSNTETVHIFKLE 134
Cdd:cd00200   216 -RGHENGVN--SVAFSPDGYLLASGSEDGTIRVWDLR 249
WD40 COG2319
WD40 repeat [General function prediction only];
2-134 1.33e-10

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 61.85  E-value: 1.33e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462556247   2 KLLKTLldiPANPTGLCALSINHSNSYLAYpGSlTSGEIVLYDGNSLKTVCTIAAHEGTLAAITFNASGSKLASASEKGT 81
Cdd:COG2319   279 ELLRTL---TGHSGGVNSVAFSPDGKLLAS-GS-DDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGT 353

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2462556247  82 ViRVFSVPDGQKLYEFrRGMKRYVTisSLVFSMDSQFLCASSNTETVHIFKLE 134
Cdd:COG2319   354 V-RLWDLATGELLRTL-TGHTGAVT--SVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 35-134 1.47e-08

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 55.03  E-value: 1.47e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462556247  35 LTSGE---IVLYDGNSLKTVCTIAAHEGTLAAITFNASGSKLASASEKGTvIRVFSVPDGQKLYEFrRGMKRYVTisSLV 111
Cdd:cd00200    67 ASGSSdktIRLWDLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKT-IKVWDVETGKCLTTL-RGHTDWVN--SVA 142

                          90       100
                  ....*....|....*....|...
gi 2462556247 112 FSMDSQFLCASSNTETVHIFKLE 134
Cdd:cd00200   143 FSPDGTFVASSSQDGTIKLWDLR 165
WD40 COG2319
WD40 repeat [General function prediction only];
38-134 3.97e-08

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 54.15  E-value: 3.97e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462556247  38 GEIVLYDGNSLKTVCTIAAHEGTLAAITFNASGSKLASASEKGTViRVFSVPDGQKLYEFrRGMKRYVTisSLVFSMDSQ 117
Cdd:COG2319   100 GTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTV-RLWDLATGKLLRTL-TGHSGAVT--SVAFSPDGK 175

                          90
                  ....*....|....*..
gi 2462556247 118 FLCASSNTETVHIFKLE 134
Cdd:COG2319   176 LLASGSDDGTVRLWDLA 192
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 16-224 9.66e-07

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 49.26  E-value: 9.66e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462556247  16 GLCALSINHSNSYLAyPGSlTSGEIVLYDGNSLKTVCTIAAHEGTLAAITFNASGSKLASASEKGTvIRVFSVPDGQKLY 95
Cdd:cd00200    11 GVTCVAFSPDGKLLA-TGS-GDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKT-IRLWDLETGECVR 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462556247  96 EFrRGMKRYVtiSSLVFSMDSQFLCASSNTETVHIFKLEQVTNSRpeepsTWSGymgkmFMAATNYLPTQVSDMM----H 171
Cdd:cd00200    88 TL-TGHTSYV--SSVAFSPDGRILSSSSRDKTIKVWDVETGKCLT-----TLRG-----HTDWVNSVAFSPDGTFvassS 154

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2462556247 172 QDRafaTARL----------NFSG-QRNICTLSTIQKLPRLLVASSSGHLYMYNLdpqDGGECV 224
Cdd:cd00200   155 QDG---TIKLwdlrtgkcvaTLTGhTGEVNSVAFSPDGEKLLSSSSDGTIKLWDL---STGKCL 212
WD40 COG2319
WD40 repeat [General function prediction only];
2-90 4.39e-05

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 44.90  E-value: 4.39e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462556247   2 KLLKTLldiPANPTGLCALSINHSNSYLAYPGSltSGEIVLYDGNSLKTVCTIAAHEGTLAAITFNASGSKLASASEKGT 81
Cdd:COG2319   321 KLLRTL---TGHTGAVRSVAFSPDGKTLASGSD--DGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGT 395


                  ....*....
gi 2462556247  82 vIRVFSVPD 90
Cdd:COG2319   396 -VRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 51-149 7.05e-05

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 43.86  E-value: 7.05e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462556247  51 VCTIAAHEGTLAAITFNASGSKLASASEKGTvIRVFSVPDGQKLyefRRGMKRYVTISSLVFSMDSQFLCASSNTETVHI 130
Cdd:cd00200     2 RRTLKGHTGGVTCVAFSPDGKLLATGSGDGT-IKVWDLETGELL---RTLKGHTGPVRDVAASADGTYLASGSSDKTIRL 77

                          90
                  ....*....|....*....
gi 2462556247 131 FKLEQvtnsrPEEPSTWSG 149
Cdd:cd00200    78 WDLET-----GECVRTLTG 91
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 2-87 4.09e-04

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 41.55  E-value: 4.09e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462556247   2 KLLKTLldiPANPTGLCALSINHSNSYLAypGSLTSGEIVLYDGNSLKTVCTIAAHEGTLAAITFNASGSKLASASEKGT 81
Cdd:cd00200   210 KCLGTL---RGHENGVNSVAFSPDGYLLA--SGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGT 284


                  ....*.
gi 2462556247  82 vIRVFS 87
Cdd:cd00200   285 -IRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
34-135 1.35e-03

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 40.28  E-value: 1.35e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462556247  34 SLTSGEIVLYDGNSLKTVCTIAAHEGTLAAITFNASGSKLASASEKGTViRVFSVPDGQKLYEFrRGMKRYVTisSLVFS 113
Cdd:COG2319    54 GAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTV-RLWDLATGLLLRTL-TGHTGAVR--SVAFS 129

                          90       100
                  ....*....|....*....|..
gi 2462556247 114 MDSQFLCASSNTETVHIFKLEQ 135
Cdd:COG2319   130 PDGKTLASGSADGTVRLWDLAT 151
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 47-87 7.02e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 33.83  E-value: 7.02e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 2462556247   47 SLKTVCTIAAHEGTLAAITFNASGSKLASASEKGTvIRVFS 87
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGT-IKLWD 40
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH