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Conserved domains on  [gi|2462559356|ref|XP_054174059|]
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small G protein signaling modulator 2 isoform X22 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RUN super family cl45896
RUN domain; RUN domain, named after RPIP8 (Rap2 interacting protein 8), UNC-14 and NESCA (new ...
 18-243 1.49e-121

RUN domain; RUN domain, named after RPIP8 (Rap2 interacting protein 8), UNC-14 and NESCA (new molecule containing SH3 at the carboxyl-terminus), is a less conserved protein motif that comprises six conserved regions, which in some proteins have considerable insertions between them. The domain core is thought to take up a predominantly alpha fold, with basic amino acids in regions A and D possibly playing a functional role in interactions with Ras GTPases. RUN domains are often found in proteins linked particularly to the functions of GTPases in the Rap and Rab families, suggesting the RUN domain may be involved in Rab-mediated membrane trafficking, possibly as a Rab-binding site. RUN domain-containing proteins could hence play important roles in multiple Ras-like GTPase signalling pathways.


The actual alignment was detected with superfamily member cd17704:

Pssm-ID: 459241  Cd Length: 180  Bit Score: 353.85  E-value: 1.49e-121
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462559356  18 KEVKQIMEEAVTRKFVHEDSSHIIALCaadphqgltrcqtpftvqgngsdkmdrvsaagayillgrqtgnkcaSAVEACL 97
Cdd:cd17704     1 KEVKQIMEEAVTRKFVHEDSSHIIALC----------------------------------------------GVVEACL 34

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462559356  98 LHQLRRRAAGFLRSDKMAALFTKVGKTCPVAGEICHKVQELQQQAEGRKPSGVSQEALRRQGSASGKAPALSPQALKHVW 177
Cdd:cd17704    35 LHLLKRRAAGFLRSDKVAALFTKVGKTYPTAGDICKKVQELQQQVEGRKNTQSTQEELRRQSSTTSKTPPLTPQAIKHIW 114

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462559356 178 VRTALIEKVLDKVVQYLAENCSKYYEKEALLADPVFGPILASLLVGPCALEYTKLKTADHYWTDPS 243
Cdd:cd17704   115 VRTALIEKVLDKIVQYIVDNCSKYYEKEALMSDPVCGPILASLLVGPCALEYTKLKTADHYWTDPS 180
PH_RUTBC cd15784
Rab-binding Pleckstrin homology domain (PH) of small G-protein signaling modulator 1 and ...
 302-470 2.59e-103

Rab-binding Pleckstrin homology domain (PH) of small G-protein signaling modulator 1 and similar proteins; Small G-protein signaling modulator 1, or RUN and TBC1 domain containing 2 (RUTBC2), as well as RUTBC1, bind to Rab9A via their Pleckstrin homology (PH) domain. They do not seem to act as GAP proteins that stimulate GTP hydrolysis by Rab9A, and RUTBC2 has been shown to also interact with Rab9B, most likely in a similar manner. RUTBC1 does stimulate GTP hydrolysis by Rab32 and Rab33B, however, while RUTBC2 appears to be a GAP for Rab36. Rab9A and associated proteins control the recycling of mannose-6-phosphate receptors from late endosomes to the trans-Golgi.


:

Pssm-ID: 275431  Cd Length: 176  Bit Score: 307.34  E-value: 2.59e-103
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462559356 302 TRLLYGKNHVLVQPKEDMEAVPGYLSLHQSA-ESLTLKWTPNQLMNGTLGDS-----ELEKSVYWDYALVVPFSQVVCIH 375
Cdd:cd15784     1 STLLYGKNNVLVQPRDDKEPIKGYLSLHQTGrGNLTLKWTPNQLMNGSSQASsaksnSLDSSVYWDYALSVNLDDIVYIH 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462559356 376 CHQQ-KSGGTLVLVSQDGIQRPPLHFPQGGHLLSFLSCLENGLLPQGQLEPPLWTQQGKGKVFPKLRKRSSIRSVDMEEM 454
Cdd:cd15784    81 CHQQdDSGGTVVLVGQDGVQRPPLHFPQGGHLLAFLSCLENGLLPHGQLDPPLWSQRGKGKVLPKLRKRSSLTSSKLSEV 160

                         170
                  ....*....|....*.
gi 2462559356 455 GTGRATDYVFRIIYPG 470
Cdd:cd15784   161 KEEQATDYVFRIIYPG 176
 
Name Accession Description Interval E-value
RUN_SGSM2 cd17704
RUN domain found in small G protein signaling modulator 2 (SGSM2) and similar proteins; SGSM2, ...
 18-243 1.49e-121

RUN domain found in small G protein signaling modulator 2 (SGSM2) and similar proteins; SGSM2, also called RUN and TBC1 domain-containing protein 1 (RUTBC1), is a GTPase-activating protein for Rab32/38, and regulates melanogenic enzyme trafficking in melanocytes. It also acts as a Rab9A effector that activates GTP hydrolysis by Rab32 and Rab33B proteins. This model contains the RUN domain of SGSM2.


Pssm-ID: 439066  Cd Length: 180  Bit Score: 353.85  E-value: 1.49e-121
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462559356  18 KEVKQIMEEAVTRKFVHEDSSHIIALCaadphqgltrcqtpftvqgngsdkmdrvsaagayillgrqtgnkcaSAVEACL 97
Cdd:cd17704     1 KEVKQIMEEAVTRKFVHEDSSHIIALC----------------------------------------------GVVEACL 34

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462559356  98 LHQLRRRAAGFLRSDKMAALFTKVGKTCPVAGEICHKVQELQQQAEGRKPSGVSQEALRRQGSASGKAPALSPQALKHVW 177
Cdd:cd17704    35 LHLLKRRAAGFLRSDKVAALFTKVGKTYPTAGDICKKVQELQQQVEGRKNTQSTQEELRRQSSTTSKTPPLTPQAIKHIW 114

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462559356 178 VRTALIEKVLDKVVQYLAENCSKYYEKEALLADPVFGPILASLLVGPCALEYTKLKTADHYWTDPS 243
Cdd:cd17704   115 VRTALIEKVLDKIVQYIVDNCSKYYEKEALMSDPVCGPILASLLVGPCALEYTKLKTADHYWTDPS 180
PH_RUTBC cd15784
Rab-binding Pleckstrin homology domain (PH) of small G-protein signaling modulator 1 and ...
 302-470 2.59e-103

Rab-binding Pleckstrin homology domain (PH) of small G-protein signaling modulator 1 and similar proteins; Small G-protein signaling modulator 1, or RUN and TBC1 domain containing 2 (RUTBC2), as well as RUTBC1, bind to Rab9A via their Pleckstrin homology (PH) domain. They do not seem to act as GAP proteins that stimulate GTP hydrolysis by Rab9A, and RUTBC2 has been shown to also interact with Rab9B, most likely in a similar manner. RUTBC1 does stimulate GTP hydrolysis by Rab32 and Rab33B, however, while RUTBC2 appears to be a GAP for Rab36. Rab9A and associated proteins control the recycling of mannose-6-phosphate receptors from late endosomes to the trans-Golgi.


Pssm-ID: 275431  Cd Length: 176  Bit Score: 307.34  E-value: 2.59e-103
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462559356 302 TRLLYGKNHVLVQPKEDMEAVPGYLSLHQSA-ESLTLKWTPNQLMNGTLGDS-----ELEKSVYWDYALVVPFSQVVCIH 375
Cdd:cd15784     1 STLLYGKNNVLVQPRDDKEPIKGYLSLHQTGrGNLTLKWTPNQLMNGSSQASsaksnSLDSSVYWDYALSVNLDDIVYIH 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462559356 376 CHQQ-KSGGTLVLVSQDGIQRPPLHFPQGGHLLSFLSCLENGLLPQGQLEPPLWTQQGKGKVFPKLRKRSSIRSVDMEEM 454
Cdd:cd15784    81 CHQQdDSGGTVVLVGQDGVQRPPLHFPQGGHLLAFLSCLENGLLPHGQLDPPLWSQRGKGKVLPKLRKRSSLTSSKLSEV 160

                         170
                  ....*....|....*.
gi 2462559356 455 GTGRATDYVFRIIYPG 470
Cdd:cd15784   161 KEEQATDYVFRIIYPG 176
PH_RBD pfam12068
Rab-binding domain (RBD); This domain has been called the Rab-binding domain (RBD). The domain ...
 303-438 1.03e-52

Rab-binding domain (RBD); This domain has been called the Rab-binding domain (RBD). The domain adopts a Ph-like fold. This domain is found associated with pfam00566.


Pssm-ID: 432305  Cd Length: 149  Bit Score: 175.39  E-value: 1.03e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462559356 303 RLLYGKNHVLVQPKEDMEAVPGYLSLHQ-SAESLTLKWTPNQLMN-------GTLGDSELE---KSVYWDYALVVPFSQV 371
Cdd:pfam12068   1 RLLYGKNNVFVYPSDIGKPIKGYLSLHQnDKGSVFLKWTPNQLMKsssqpssASSDSEELQspdGKNPWSWAINVNVKEL 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2462559356 372 VCIHCHQQK--SGGTLVLVSQDGIQRPPLHFPQGGHLLSFLSCLENGLLPQGQLEPPLWTQQGKGKVFP 438
Cdd:pfam12068  81 KYIHKHQPNegSPSYIILVTQDGGQFPPLHFPHGGHLLLFLSCLESGLFPVVRLDPPLSRSLSKGKLFP 149
RUN pfam02759
RUN domain; This domain is present in several proteins that are linked to the functions of ...
 90-235 1.62e-31

RUN domain; This domain is present in several proteins that are linked to the functions of GTPases in the Rap and Rab families. They could hence play important roles in multiple Ras-like GTPase signalling pathways. The domain is comprises six conserved regions, which in some proteins have considerable insertions between them. The domain core is thought to take up a predominantly alpha fold, with basic amino acids in regions A and D possibly playing a functional role in interactions with Ras GTPases.


Pssm-ID: 460679  Cd Length: 134  Bit Score: 118.15  E-value: 1.62e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462559356  90 ASAVEACLLHQLRR------RAAGFLRSDKMAALFTKVGKTCPVAGEICHKVQELQQQAEGRkpsgvsqealrrqgsasg 163
Cdd:pfam02759   3 CAALEALLSHGLKRssllilRAAGLLPERSFWALLERVGKLVPPAEELLSSVQELEQIHTPY------------------ 64

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2462559356 164 kapalSPQALKHVWVRTALIEKVLDKVVQYLAENC---SKYYEKEALLADPVFGPILASLLVGPCALEYTKLKTA 235
Cdd:pfam02759  65 -----SPDGRGRAWIRLALNEKLLDQWLKLLLSNKellSEYYEPWALLADPEFGEILLGLLVGLSALDFNLCLKL 134
RUN smart00593
domain involved in Ras-like GTPase signaling;
174-230 1.02e-14

domain involved in Ras-like GTPase signaling;


Pssm-ID: 214736 [Multi-domain]  Cd Length: 64  Bit Score: 68.79  E-value: 1.02e-14
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462559356  174 KHVWVRTALIEKVLDKVVQYLAENC---SKYYEKEALLADPVFGPILASLLVGPCALEYT 230
Cdd:smart00593   1 FRAWIRLALNEKLLSSWLNLLLSDEellSKYYEPWAFLRDPEEGEQLLGLLVGLSALDFN 60
 
Name Accession Description Interval E-value
RUN_SGSM2 cd17704
RUN domain found in small G protein signaling modulator 2 (SGSM2) and similar proteins; SGSM2, ...
 18-243 1.49e-121

RUN domain found in small G protein signaling modulator 2 (SGSM2) and similar proteins; SGSM2, also called RUN and TBC1 domain-containing protein 1 (RUTBC1), is a GTPase-activating protein for Rab32/38, and regulates melanogenic enzyme trafficking in melanocytes. It also acts as a Rab9A effector that activates GTP hydrolysis by Rab32 and Rab33B proteins. This model contains the RUN domain of SGSM2.


Pssm-ID: 439066  Cd Length: 180  Bit Score: 353.85  E-value: 1.49e-121
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462559356  18 KEVKQIMEEAVTRKFVHEDSSHIIALCaadphqgltrcqtpftvqgngsdkmdrvsaagayillgrqtgnkcaSAVEACL 97
Cdd:cd17704     1 KEVKQIMEEAVTRKFVHEDSSHIIALC----------------------------------------------GVVEACL 34

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462559356  98 LHQLRRRAAGFLRSDKMAALFTKVGKTCPVAGEICHKVQELQQQAEGRKPSGVSQEALRRQGSASGKAPALSPQALKHVW 177
Cdd:cd17704    35 LHLLKRRAAGFLRSDKVAALFTKVGKTYPTAGDICKKVQELQQQVEGRKNTQSTQEELRRQSSTTSKTPPLTPQAIKHIW 114

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462559356 178 VRTALIEKVLDKVVQYLAENCSKYYEKEALLADPVFGPILASLLVGPCALEYTKLKTADHYWTDPS 243
Cdd:cd17704   115 VRTALIEKVLDKIVQYIVDNCSKYYEKEALMSDPVCGPILASLLVGPCALEYTKLKTADHYWTDPS 180
PH_RUTBC cd15784
Rab-binding Pleckstrin homology domain (PH) of small G-protein signaling modulator 1 and ...
 302-470 2.59e-103

Rab-binding Pleckstrin homology domain (PH) of small G-protein signaling modulator 1 and similar proteins; Small G-protein signaling modulator 1, or RUN and TBC1 domain containing 2 (RUTBC2), as well as RUTBC1, bind to Rab9A via their Pleckstrin homology (PH) domain. They do not seem to act as GAP proteins that stimulate GTP hydrolysis by Rab9A, and RUTBC2 has been shown to also interact with Rab9B, most likely in a similar manner. RUTBC1 does stimulate GTP hydrolysis by Rab32 and Rab33B, however, while RUTBC2 appears to be a GAP for Rab36. Rab9A and associated proteins control the recycling of mannose-6-phosphate receptors from late endosomes to the trans-Golgi.


Pssm-ID: 275431  Cd Length: 176  Bit Score: 307.34  E-value: 2.59e-103
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462559356 302 TRLLYGKNHVLVQPKEDMEAVPGYLSLHQSA-ESLTLKWTPNQLMNGTLGDS-----ELEKSVYWDYALVVPFSQVVCIH 375
Cdd:cd15784     1 STLLYGKNNVLVQPRDDKEPIKGYLSLHQTGrGNLTLKWTPNQLMNGSSQASsaksnSLDSSVYWDYALSVNLDDIVYIH 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462559356 376 CHQQ-KSGGTLVLVSQDGIQRPPLHFPQGGHLLSFLSCLENGLLPQGQLEPPLWTQQGKGKVFPKLRKRSSIRSVDMEEM 454
Cdd:cd15784    81 CHQQdDSGGTVVLVGQDGVQRPPLHFPQGGHLLAFLSCLENGLLPHGQLDPPLWSQRGKGKVLPKLRKRSSLTSSKLSEV 160

                         170
                  ....*....|....*.
gi 2462559356 455 GTGRATDYVFRIIYPG 470
Cdd:cd15784   161 KEEQATDYVFRIIYPG 176
RUN_SGSM1 cd17703
RUN domain found in small G protein signaling modulator 1 (SGSM1) and similar proteins; SGSM1, ...
 18-243 5.50e-96

RUN domain found in small G protein signaling modulator 1 (SGSM1) and similar proteins; SGSM1, also called RUN and TBC1 domain-containing protein 2 (RUTBC2), interacts with numerous Rab family members, functioning as Rab effector for some, and as GTPase activator for others. It is a Rab9A effector and GTPase-activating protein for Rab36, and links Rab9A function to Rab36 function in the endosomal system. This model contains the RUN domain of SGSM1.


Pssm-ID: 439065  Cd Length: 177  Bit Score: 288.45  E-value: 5.50e-96
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462559356  18 KEVKQIMEEAVTRKFVHEDSSHIIALCAAdphqgltrcqtpftvqgngsdkmdrvsaagayillgrqtgnkcasaVEACL 97
Cdd:cd17703     1 KEVKQIMEEAVTRKFVHEDSSHIISFCAA----------------------------------------------VEACV 34

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462559356  98 LHQLRRRAAGFLRSDKMAALFTKVGKTCPVAGEICHKVQELQQQAEGRKPSG-VSQEALRRqgsaSGKAPALSPQALKHV 176
Cdd:cd17703    35 LHGLKRRAAGFLRSNKIAALFMKVGKSFPPAEELCRKVQELEQLLENKRNQMqGLQENVRK----MPKLPNLSPQAIKHL 110

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2462559356 177 WVRTALIEKVLDKVVQYLAENCSKYYEKEALLADPVFGPILASLLVGPCALEYTKLKTADHYWTDPS 243
Cdd:cd17703   111 WIRTALFEKVLDKIVHYLVENSSKYYEKEALLMDPVDGPILASLLVGPCALEYTKMKTADHFWTDPS 177
RUN_SGSM1_like cd17687
RUN domain found in small G protein signaling modulators, SGSM1, SGSM2, and similar proteins; ...
 18-231 6.68e-78

RUN domain found in small G protein signaling modulators, SGSM1, SGSM2, and similar proteins; SGSM1, also called RUN and TBC1 domain-containing protein 2 (RUTBC2), interacts with numerous Rab family members, functioning as Rab effector for some, and as GTPase activator for others. It is a Rab9A effector and GTPase-activating protein for Rab36, and links Rab9A function to Rab36 function in the endosomal system. SGSM2, also called RUN and TBC1 domain-containing protein 1 (RUTBC1), is a GTPase-activating protein for Rab32/38, and regulates melanogenic enzyme trafficking in melanocytes. It also acts as a Rab9A effector that activates GTP hydrolysis by Rab32 and Rab33B proteins. This model contains the RUN domain of SGSM1 and SGSM2.


Pssm-ID: 439049  Cd Length: 161  Bit Score: 241.42  E-value: 6.68e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462559356  18 KEVKQIMEEAVTRKFVHEDSSHIIALCAAdphqgltrcqtpftvqgngsdkmdrvsaagayillgrqtgnkcasaVEACL 97
Cdd:cd17687     1 KEVKQLMEEAVTRKFIHEDSSSVTSLCGA----------------------------------------------VDACL 34

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462559356  98 LHQLRRRAAGFLRSDKMAALFTKVGKTCPVAGEICHKVQELQQQAEGRKPSGVSqealrrqGSASGKAPALSPQALKHVW 177
Cdd:cd17687    35 LHGLRKRALGLFRSSSTFSLLQKVAKSCPPAADILRKVQEIENLSENKRSSSSS-------GSNSSNSHGNSSSNRKILW 107

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2462559356 178 VRTALIEKVLDKVVQYLAENCSKYYEKEALLADPVFGPILASLLVGPCALEYTK 231
Cdd:cd17687   108 IRIALFEKVLDKIVDYLVENASKYYEKEALMADPVDGPLLASLLVGPCALDYTK 161
PH_RBD pfam12068
Rab-binding domain (RBD); This domain has been called the Rab-binding domain (RBD). The domain ...
 303-438 1.03e-52

Rab-binding domain (RBD); This domain has been called the Rab-binding domain (RBD). The domain adopts a Ph-like fold. This domain is found associated with pfam00566.


Pssm-ID: 432305  Cd Length: 149  Bit Score: 175.39  E-value: 1.03e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462559356 303 RLLYGKNHVLVQPKEDMEAVPGYLSLHQ-SAESLTLKWTPNQLMN-------GTLGDSELE---KSVYWDYALVVPFSQV 371
Cdd:pfam12068   1 RLLYGKNNVFVYPSDIGKPIKGYLSLHQnDKGSVFLKWTPNQLMKsssqpssASSDSEELQspdGKNPWSWAINVNVKEL 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2462559356 372 VCIHCHQQK--SGGTLVLVSQDGIQRPPLHFPQGGHLLSFLSCLENGLLPQGQLEPPLWTQQGKGKVFP 438
Cdd:pfam12068  81 KYIHKHQPNegSPSYIILVTQDGGQFPPLHFPHGGHLLLFLSCLESGLFPVVRLDPPLSRSLSKGKLFP 149
RUN pfam02759
RUN domain; This domain is present in several proteins that are linked to the functions of ...
 90-235 1.62e-31

RUN domain; This domain is present in several proteins that are linked to the functions of GTPases in the Rap and Rab families. They could hence play important roles in multiple Ras-like GTPase signalling pathways. The domain is comprises six conserved regions, which in some proteins have considerable insertions between them. The domain core is thought to take up a predominantly alpha fold, with basic amino acids in regions A and D possibly playing a functional role in interactions with Ras GTPases.


Pssm-ID: 460679  Cd Length: 134  Bit Score: 118.15  E-value: 1.62e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462559356  90 ASAVEACLLHQLRR------RAAGFLRSDKMAALFTKVGKTCPVAGEICHKVQELQQQAEGRkpsgvsqealrrqgsasg 163
Cdd:pfam02759   3 CAALEALLSHGLKRssllilRAAGLLPERSFWALLERVGKLVPPAEELLSSVQELEQIHTPY------------------ 64

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2462559356 164 kapalSPQALKHVWVRTALIEKVLDKVVQYLAENC---SKYYEKEALLADPVFGPILASLLVGPCALEYTKLKTA 235
Cdd:pfam02759  65 -----SPDGRGRAWIRLALNEKLLDQWLKLLLSNKellSEYYEPWALLADPEFGEILLGLLVGLSALDFNLCLKL 134
RUN smart00593
domain involved in Ras-like GTPase signaling;
174-230 1.02e-14

domain involved in Ras-like GTPase signaling;


Pssm-ID: 214736 [Multi-domain]  Cd Length: 64  Bit Score: 68.79  E-value: 1.02e-14
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462559356  174 KHVWVRTALIEKVLDKVVQYLAENC---SKYYEKEALLADPVFGPILASLLVGPCALEYT 230
Cdd:smart00593   1 FRAWIRLALNEKLLSSWLNLLLSDEellSKYYEPWAFLRDPEEGEQLLGLLVGLSALDFN 60
RUN cd17671
RUN domain; RUN domain, named after RPIP8 (Rap2 interacting protein 8), UNC-14 and NESCA (new ...
 91-227 1.32e-12

RUN domain; RUN domain, named after RPIP8 (Rap2 interacting protein 8), UNC-14 and NESCA (new molecule containing SH3 at the carboxyl-terminus), is a less conserved protein motif that comprises six conserved regions, which in some proteins have considerable insertions between them. The domain core is thought to take up a predominantly alpha fold, with basic amino acids in regions A and D possibly playing a functional role in interactions with Ras GTPases. RUN domains are often found in proteins linked particularly to the functions of GTPases in the Rap and Rab families, suggesting the RUN domain may be involved in Rab-mediated membrane trafficking, possibly as a Rab-binding site. RUN domain-containing proteins could hence play important roles in multiple Ras-like GTPase signalling pathways.


Pssm-ID: 439038  Cd Length: 154  Bit Score: 65.52  E-value: 1.32e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462559356  91 SAVEACLLHQLRRRAAGFLRSDkmaalftkvgktcpvageICHKVQELQQQAEGRKPSGVSQEA--LRRQGSASGKApal 168
Cdd:cd17671    36 AALEAILSHGLKPKRFGGGKVS------------------FWDFLEALEKLLPAPSLKQAIRDInsLSNVKTDDGRG--- 94

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462559356 169 spqalkHVWVRTALIEKVLDKVVQYLAEN---CSKYYEKEALLADPVFGPILASLLVGPCAL 227
Cdd:cd17671    95 ------RAWIRLALNEKSLESYLAALLSDqslLRKYYEPWALLRDPEEAELFLSLLVGLSSL 150
PH-like cd00900
Pleckstrin homology-like domain; The PH-like family includes the PH domain, both the Shc-like ...
 308-413 2.28e-07

Pleckstrin homology-like domain; The PH-like family includes the PH domain, both the Shc-like and IRS-like PTB domains, the ran-binding domain, the EVH1 domain, a domain in neurobeachin and the third domain of FERM. All of these domains have a PH fold, but lack significant sequence similarity. They are generally involved in targeting to protein to the appropriate cellular location or interacting with a binding partner. This domain family possesses multiple functions including the ability to bind inositol phosphates and to other proteins.


Pssm-ID: 275390  Cd Length: 89  Bit Score: 48.55  E-value: 2.28e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462559356 308 KNHVLVQPKEDMEAVPGYLSLHQSaeslTLKWTPNQLMngtlgdseleksvywDYALVVPFSQVVCIHCHQQ-KSGGTLV 386
Cdd:cd00900     2 KFRAVRVYREPTKRVEGTLYITSD----RLILRDKNDG---------------GLELSIPISDIVNVNVSPQgPSSRYLV 62

                          90       100
                  ....*....|....*....|....*..
gi 2462559356 387 LVSQDGIQRPPLHFPQGGHLLSFLSCL 413
Cdd:cd00900    63 LVLKDRGEFVGFSFPKEEDAIEISDAL 89
RUN_RUFY3 cd17696
RUN domain found in RUN and FYVE domain-containing protein 3 (RUFY3) and similar proteins; ...
 93-223 1.83e-03

RUN domain found in RUN and FYVE domain-containing protein 3 (RUFY3) and similar proteins; RUFY3, also called Rap2-interacting protein x (RIPx or RPIPx), or single axon-regulated protein (singar), is an N-terminal RUN domain and a C-terminal FYVE domain containing protein predominantly expressed in the brain. It suppresses formation of surplus axons for neuronal polarity. Unlike other RUFY proteins, RUFY3 can associate with the GTP-bound active form of Rab5. This model represents the RUN domain of RUFY3.


Pssm-ID: 439058  Cd Length: 156  Bit Score: 39.21  E-value: 1.83e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462559356  93 VEACLLHQLRRRAAGFLRSDKMAALFTKVGKTCPVAGEICHKVQELqqqaegrkpsgvsqealrrqgsasgkaPAL-SPQ 171
Cdd:cd17696    41 MEHCLKHGLKAKKTFLGQNKSFWGPLELVEKLVPEAAEITASVKDL---------------------------PGLkTPV 93

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2462559356 172 ALKHVWVRTALIEKVLDKVVQYL---AENCSKYYEKEALLADPVfGPILASLLVG 223
Cdd:cd17696    94 GRGRAWLRLALMQKKLSEYMKALinrKDLLSEFYEPNALMMEEE-GAIIAGLLVG 147
RUN_RUFY2 cd17695
RUN domain found in RUN and FYVE domain-containing protein 2 (RUFY2) and similar proteins; ...
 93-223 2.97e-03

RUN domain found in RUN and FYVE domain-containing protein 2 (RUFY2) and similar proteins; RUFY2, also called Rab4-interacting protein related, is a novel embryonic factor that contains an N-terminal RUN domain and a C-terminal FYVE domain with two coiled-coil domains in-between. It is present in the nucleus at early stages of embryonic development. It may have both endosomal functions in the cytoplasm and nuclear functions. This model represents the RUN domain of RUFY2.


Pssm-ID: 439057  Cd Length: 156  Bit Score: 38.42  E-value: 2.97e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462559356  93 VEACLLHQLRRRAAGFLRSDKMAALFTKVGKTCPVAGEICHKVQELqqqaegrkpsgvsqealrrqgsasgkaPAL-SPQ 171
Cdd:cd17695    41 MEHCLKHGLKVRKSFLSYNKTIWGPLELVEKLCPEAEEIAASVRDL---------------------------PGLkTPL 93

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2462559356 172 ALKHVWVRTALIEKvldKVVQYL------AENCSKYYEKEALLADPVfGPILASLLVG 223
Cdd:cd17695    94 GRARAWLRLALMQK---KLADYLrcliirRDLLSEFYEYHALMMEEE-GAVIVGLLVG 147
RUN_RUFY4_like cd17682
RUN domain found in RUN and FYVE domain-containing protein 4 (RUFY4), FYVE and coiled-coil ...
 178-221 9.97e-03

RUN domain found in RUN and FYVE domain-containing protein 4 (RUFY4), FYVE and coiled-coil domain-containing protein 1 (FYCO1), and similar proteins; The family includes RUFY4 and FYCO1. RUFY4 acts as a positive regulator that enhances autophagy and lysosome tethering in response to Interleukin-4. It is expressed in a cell-specific manner or under specific immunological conditions associated with IL4 expression such as allergic asthma. FYCO1, also called zinc finger FYVE domain-containing protein 7 (ZFYVE7), is a multidomain autophagy adaptor protein that interacts with kinesin motor proteins and with the autophagosomal membrane components microtubule-associated protein 1 light chain 3 (LC3), Rab7, and phosphatidylinositol 3-phosphate (PI3P), to mediate microtubule plus-end-directed autophagosome transport. Both RUFY4 and FYCO1 contain an N-terminal RUN domain and a C-terminal FYVE domain with two coiled-coil domains in-between; this model represents the RUN domain.


Pssm-ID: 439044  Cd Length: 150  Bit Score: 36.82  E-value: 9.97e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 2462559356 178 VRTALIEKVLDKVVQYLAEN---CSKYYEKEALLADPVFGPILASLL 221
Cdd:cd17682    94 IRYALNKKCLHDPVQQLVKNpklLSDYYSPDSILGNEILSEILLSLL 140
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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