NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|2462564909|ref|XP_054176750|]
View 

hyaluronan synthase 1 isoform X1 [Homo sapiens]

Protein Classification

glycosyltransferase family protein( domain architecture ID 27718)

glycosyltransferase family protein may synthesize oligosaccharides, polysaccharides, and glycoconjugates by transferring the sugar moiety from an activated nucleotide-sugar donor to an acceptor molecule, which may be a growing oligosaccharide, a lipid, or a protein

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Glyco_tranf_GTA_type super family cl11394
Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a ...
 96-310 6.36e-40

Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Glycosyltransferases (GTs) are enzymes that synthesize oligosaccharides, polysaccharides, and glycoconjugates by transferring the sugar moiety from an activated nucleotide-sugar donor to an acceptor molecule, which may be a growing oligosaccharide, a lipid, or a protein. Based on the stereochemistry of the donor and acceptor molecules, GTs are classified as either retaining or inverting enzymes. To date, all GT structures adopt one of two possible folds, termed GT-A fold and GT-B fold. This hierarchy includes diverse families of glycosyl transferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. The majority of the proteins in this superfamily are Glycosyltransferase family 2 (GT-2) proteins. But it also includes families GT-43, GT-6, GT-8, GT13 and GT-7; which are evolutionarily related to GT-2 and share structure similarities.


The actual alignment was detected with superfamily member cd06434:

Pssm-ID: 472172 [Multi-domain]  Cd Length: 235  Bit Score: 140.08  E-value: 6.36e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462564909  96 SVALTISAYQEDPAYLRQCLASARALlyprARLRVLMVVDGNRAEDLYMVdmfrevfadedpatyvwdgnyhqpwepaaa 175
Cdd:cd06434     1 DVTVIIPVYDEDPDVFRECLRSILRQ----KPLEIIVVTDGDDEPYLSIL------------------------------ 46

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462564909 176 gavgagayreveaedpgrlavEALVRTRRCVCVAQRWGGKREVMYTAFKALgdSVDYVQVCDSDTRLDPMALLELVRVLd 255
Cdd:cd06434    47 ---------------------SQTVKYGGIFVITVPHPGKRRALAEGIRHV--TTDIVVLLDSDTVWPPNALPEMLKPF- 102

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2462564909 256 EDPRVGAVGGDVRILNPLDSWVSFLSSLRYWVAFNVERACQSYFHCVSCISGPLG 310
Cdd:cd06434   103 EDPKVGGVGTNQRILRPRDSKWSFLAAEYLERRNEEIRAAMSYDGGVPCLSGRTA 157
 
Name Accession Description Interval E-value
GT2_HAS cd06434
Hyaluronan synthases catalyze polymerization of hyaluronan; Hyaluronan synthases (HASs) are ...
 96-310 6.36e-40

Hyaluronan synthases catalyze polymerization of hyaluronan; Hyaluronan synthases (HASs) are bi-functional glycosyltransferases that catalyze polymerization of hyaluronan. HASs transfer both GlcUA and GlcNAc in beta-(1,3) and beta-(1,4) linkages, respectively to the hyaluronan chain using UDP-GlcNAc and UDP-GlcUA as substrates. HA is made as a free glycan, not attached to a protein or lipid. HASs do not need a primer for HA synthesis; they initiate HA biosynthesis de novo with only UDP-GlcNAc, UDP-GlcUA, and Mg2+. Hyaluronan (HA) is a linear heteropolysaccharide composed of (1-3)-linked beta-D-GlcUA-beta-D-GlcNAc disaccharide repeats. It can be found in vertebrates and a few microbes and is typically on the cell surface or in the extracellular space, but is also found inside mammalian cells. Hyaluronan has several physiochemical and biological functions such as space filling, lubrication, and providing a hydrated matrix through which cells can migrate.


Pssm-ID: 133056 [Multi-domain]  Cd Length: 235  Bit Score: 140.08  E-value: 6.36e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462564909  96 SVALTISAYQEDPAYLRQCLASARALlyprARLRVLMVVDGNRAEDLYMVdmfrevfadedpatyvwdgnyhqpwepaaa 175
Cdd:cd06434     1 DVTVIIPVYDEDPDVFRECLRSILRQ----KPLEIIVVTDGDDEPYLSIL------------------------------ 46

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462564909 176 gavgagayreveaedpgrlavEALVRTRRCVCVAQRWGGKREVMYTAFKALgdSVDYVQVCDSDTRLDPMALLELVRVLd 255
Cdd:cd06434    47 ---------------------SQTVKYGGIFVITVPHPGKRRALAEGIRHV--TTDIVVLLDSDTVWPPNALPEMLKPF- 102

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2462564909 256 EDPRVGAVGGDVRILNPLDSWVSFLSSLRYWVAFNVERACQSYFHCVSCISGPLG 310
Cdd:cd06434   103 EDPKVGGVGTNQRILRPRDSKWSFLAAEYLERRNEEIRAAMSYDGGVPCLSGRTA 157
Chitin_synth_2 pfam03142
Chitin synthase; Members of this family are fungal chitin synthase EC:2.4.1.16 enzymes. They ...
 228-307 3.68e-08

Chitin synthase; Members of this family are fungal chitin synthase EC:2.4.1.16 enzymes. They catalyze chitin synthesis as follows: UDP-N-acetyl-D-glucosamine + {(1,4)-(N-acetyl-beta-D-glucosaminyl)}(N) <=> UDP + {(1,4)-(N-acetyl-beta-D-glucosaminyl)}(N+1).


Pssm-ID: 367353 [Multi-domain]  Cd Length: 527  Bit Score: 54.77  E-value: 3.68e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462564909 228 DSVDYVQVCDSDTRLDPMALLELVRVLDEDPRVGAVGGDVRILNPLDSWVSFLSSLRYWVAFNVERACQSYFHCVSCISG 307
Cdd:pfam03142 200 DFYEYVLMVDADTKVFPDSLTRMVACMVDDPEIMGLCGETKIANKRQSWVTAIQVFEYYISHHLSKAFESVFGGVTCLPG 279
BcsA COG1215
Glycosyltransferase, catalytic subunit of cellulose synthase and poly-beta-1, ...
 62-265 4.93e-07

Glycosyltransferase, catalytic subunit of cellulose synthase and poly-beta-1,6-N-acetylglucosamine synthase [Cell motility];


Pssm-ID: 440828 [Multi-domain]  Cd Length: 303  Bit Score: 50.51  E-value: 4.93e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462564909  62 FLSAHLVAQSLFAYLehrrvaAAARGPLDAATARSVALTISAYQEdPAYLRQCLASARALLYPRARLRVLMVVDGNRAEd 141
Cdd:COG1215     2 LLLLALLALLYLLLL------ALARRRRAPADLPRVSVIIPAYNE-EAVIEETLRSLLAQDYPKEKLEVIVVDDGSTDE- 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462564909 142 lyMVDMFREVFADEDPATYVwdgnyhqpwepaaagavgagayreveaedpgrlavealvrtrrcvcVAQRWGGKREVMYT 221
Cdd:COG1215    74 --TAEIARELAAEYPRVRVI----------------------------------------------ERPENGGKAAALNA 105

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 2462564909 222 AFKAlgDSVDYVQVCDSDTRLDPMALLELVRVLdEDPRVGAVGG 265
Cdd:COG1215   106 GLKA--ARGDIVVFLDADTVLDPDWLRRLVAAF-ADPGVGASGA 146
 
Name Accession Description Interval E-value
GT2_HAS cd06434
Hyaluronan synthases catalyze polymerization of hyaluronan; Hyaluronan synthases (HASs) are ...
 96-310 6.36e-40

Hyaluronan synthases catalyze polymerization of hyaluronan; Hyaluronan synthases (HASs) are bi-functional glycosyltransferases that catalyze polymerization of hyaluronan. HASs transfer both GlcUA and GlcNAc in beta-(1,3) and beta-(1,4) linkages, respectively to the hyaluronan chain using UDP-GlcNAc and UDP-GlcUA as substrates. HA is made as a free glycan, not attached to a protein or lipid. HASs do not need a primer for HA synthesis; they initiate HA biosynthesis de novo with only UDP-GlcNAc, UDP-GlcUA, and Mg2+. Hyaluronan (HA) is a linear heteropolysaccharide composed of (1-3)-linked beta-D-GlcUA-beta-D-GlcNAc disaccharide repeats. It can be found in vertebrates and a few microbes and is typically on the cell surface or in the extracellular space, but is also found inside mammalian cells. Hyaluronan has several physiochemical and biological functions such as space filling, lubrication, and providing a hydrated matrix through which cells can migrate.


Pssm-ID: 133056 [Multi-domain]  Cd Length: 235  Bit Score: 140.08  E-value: 6.36e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462564909  96 SVALTISAYQEDPAYLRQCLASARALlyprARLRVLMVVDGNRAEDLYMVdmfrevfadedpatyvwdgnyhqpwepaaa 175
Cdd:cd06434     1 DVTVIIPVYDEDPDVFRECLRSILRQ----KPLEIIVVTDGDDEPYLSIL------------------------------ 46

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462564909 176 gavgagayreveaedpgrlavEALVRTRRCVCVAQRWGGKREVMYTAFKALgdSVDYVQVCDSDTRLDPMALLELVRVLd 255
Cdd:cd06434    47 ---------------------SQTVKYGGIFVITVPHPGKRRALAEGIRHV--TTDIVVLLDSDTVWPPNALPEMLKPF- 102

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2462564909 256 EDPRVGAVGGDVRILNPLDSWVSFLSSLRYWVAFNVERACQSYFHCVSCISGPLG 310
Cdd:cd06434   103 EDPKVGGVGTNQRILRPRDSKWSFLAAEYLERRNEEIRAAMSYDGGVPCLSGRTA 157
CESA_like cd06423
CESA_like is the cellulose synthase superfamily; The cellulose synthase (CESA) superfamily ...
 213-310 4.72e-20

CESA_like is the cellulose synthase superfamily; The cellulose synthase (CESA) superfamily includes a wide variety of glycosyltransferase family 2 enzymes that share the common characteristic of catalyzing the elongation of polysaccharide chains. The members include cellulose synthase catalytic subunit, chitin synthase, glucan biosynthesis protein and other families of CESA-like proteins. Cellulose synthase catalyzes the polymerization reaction of cellulose, an aggregate of unbranched polymers of beta-1,4-linked glucose residues in plants, most algae, some bacteria and fungi, and even some animals. In bacteria, algae and lower eukaryotes, there is a second unrelated type of cellulose synthase (Type II), which produces acylated cellulose, a derivative of cellulose. Chitin synthase catalyzes the incorporation of GlcNAc from substrate UDP-GlcNAc into chitin, which is a linear homopolymer of beta-(1,4)-linked GlcNAc residues and Glucan Biosynthesis protein catalyzes the elongation of beta-1,2 polyglucose chains of Glucan.


Pssm-ID: 133045 [Multi-domain]  Cd Length: 180  Bit Score: 85.74  E-value: 4.72e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462564909 213 GGKREVMYTAFKALgdSVDYVQVCDSDTRLDPMALLELVRVLDEDPRVGAVGGDVRILNPLDSWVSFLSSLRYWVAFNVE 292
Cdd:cd06423    64 GGKAGALNAGLRHA--KGDIVVVLDADTILEPDALKRLVVPFFADPKVGAVQGRVRVRNGSENLLTRLQAIEYLSIFRLG 141

                          90
                  ....*....|....*...
gi 2462564909 293 RACQSYFHCVSCISGPLG 310
Cdd:cd06423   142 RRAQSALGGVLVLSGAFG 159
Chitin_synth_2 pfam03142
Chitin synthase; Members of this family are fungal chitin synthase EC:2.4.1.16 enzymes. They ...
 228-307 3.68e-08

Chitin synthase; Members of this family are fungal chitin synthase EC:2.4.1.16 enzymes. They catalyze chitin synthesis as follows: UDP-N-acetyl-D-glucosamine + {(1,4)-(N-acetyl-beta-D-glucosaminyl)}(N) <=> UDP + {(1,4)-(N-acetyl-beta-D-glucosaminyl)}(N+1).


Pssm-ID: 367353 [Multi-domain]  Cd Length: 527  Bit Score: 54.77  E-value: 3.68e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462564909 228 DSVDYVQVCDSDTRLDPMALLELVRVLDEDPRVGAVGGDVRILNPLDSWVSFLSSLRYWVAFNVERACQSYFHCVSCISG 307
Cdd:pfam03142 200 DFYEYVLMVDADTKVFPDSLTRMVACMVDDPEIMGLCGETKIANKRQSWVTAIQVFEYYISHHLSKAFESVFGGVTCLPG 279
CESA_like_1 cd06439
CESA_like_1 is a member of the cellulose synthase (CESA) superfamily; This is a subfamily of ...
 90-309 4.38e-08

CESA_like_1 is a member of the cellulose synthase (CESA) superfamily; This is a subfamily of cellulose synthase (CESA) superfamily. CESA superfamily includes a wide variety of glycosyltransferase family 2 enzymes that share the common characteristic of catalyzing the elongation of polysaccharide chains. The members of the superfamily include cellulose synthase catalytic subunit, chitin synthase, glucan biosynthesis protein and other families of CESA-like proteins.


Pssm-ID: 133061 [Multi-domain]  Cd Length: 251  Bit Score: 53.36  E-value: 4.38e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462564909  90 DAATARSVALTISAYQEDpAYLRQCLASARALLYPRARLRVLMVVDGNRaedlymvdmfrevfadedpatyvwDGNYhqp 169
Cdd:cd06439    24 DPAYLPTVTIIIPAYNEE-AVIEAKLENLLALDYPRDRLEIIVVSDGST------------------------DGTA--- 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462564909 170 wepaaagavgaGAYREVEAEDPGRLAVEAlvrtRRcvcvaqrwgGKREVMYTAFKALgdSVDYVQVCDSDTRLDPMALLE 249
Cdd:cd06439    76 -----------EIAREYADKGVKLLRFPE----RR---------GKAAALNRALALA--TGEIVVFTDANALLDPDALRL 129

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462564909 250 LVRVLdEDPRVGAVGGDVRILNPldSWVSFLSSLrYWVAFNVERACQSYFHCVSCISGPL 309
Cdd:cd06439   130 LVRHF-ADPSVGAVSGELVIVDG--GGSGSGEGL-YWKYENWLKRAESRLGSTVGANGAI 185
Chitin_synth_C cd04190
C-terminal domain of Chitin Synthase catalyzes the incorporation of GlcNAc from substrate ...
 213-307 2.36e-07

C-terminal domain of Chitin Synthase catalyzes the incorporation of GlcNAc from substrate UDP-GlcNAc into chitin; Chitin synthase, also called UDP-N-acetyl-D-glucosamine:chitin 4-beta-N-acetylglucosaminyltransferase, catalyzes the incorporation of GlcNAc from substrate UDP-GlcNAc into chitin, which is a linear homopolymer of GlcNAc residues formed by covalent beta-1,4 linkages. Chitin is an important component of the cell wall of fungi and bacteria and it is synthesized on the cytoplasmic surface of the cell membrane by membrane bound chitin synthases. Studies with fungi have revealed that most of them contain more than one chitin synthase gene. At least five subclasses of chitin synthases have been identified.


Pssm-ID: 133033 [Multi-domain]  Cd Length: 244  Bit Score: 51.15  E-value: 2.36e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462564909 213 GGKR--EVMYtaFKALGDSV-----DYVQVCDSDTRLDPMALLELVRVLDEDPRVGAVGGDVRILNPLDSWVSFLSSLRY 285
Cdd:cd04190    52 RGKRdsQLWF--FNYFCRVLfpddpEFILLVDADTKFDPDSIVQLYKAMDKDPEIGGVCGEIHPMGKKQGPLVMYQVFEY 129

                          90       100
                  ....*....|....*....|..
gi 2462564909 286 WVAFNVERACQSYFHCVSCISG 307
Cdd:cd04190   130 AISHWLDKAFESVFGFVTCLPG 151
BcsA COG1215
Glycosyltransferase, catalytic subunit of cellulose synthase and poly-beta-1, ...
 62-265 4.93e-07

Glycosyltransferase, catalytic subunit of cellulose synthase and poly-beta-1,6-N-acetylglucosamine synthase [Cell motility];


Pssm-ID: 440828 [Multi-domain]  Cd Length: 303  Bit Score: 50.51  E-value: 4.93e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462564909  62 FLSAHLVAQSLFAYLehrrvaAAARGPLDAATARSVALTISAYQEdPAYLRQCLASARALLYPRARLRVLMVVDGNRAEd 141
Cdd:COG1215     2 LLLLALLALLYLLLL------ALARRRRAPADLPRVSVIIPAYNE-EAVIEETLRSLLAQDYPKEKLEVIVVDDGSTDE- 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462564909 142 lyMVDMFREVFADEDPATYVwdgnyhqpwepaaagavgagayreveaedpgrlavealvrtrrcvcVAQRWGGKREVMYT 221
Cdd:COG1215    74 --TAEIARELAAEYPRVRVI----------------------------------------------ERPENGGKAAALNA 105

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 2462564909 222 AFKAlgDSVDYVQVCDSDTRLDPMALLELVRVLdEDPRVGAVGG 265
Cdd:COG1215   106 GLKA--ARGDIVVFLDADTVLDPDWLRRLVAAF-ADPGVGASGA 146
Glyco_tranf_2_3 pfam13641
Glycosyltransferase like family 2; Members of this family of prokaryotic proteins include ...
 95-285 5.46e-05

Glycosyltransferase like family 2; Members of this family of prokaryotic proteins include putative glucosyltransferase, which are involved in bacterial capsule biosynthesis.


Pssm-ID: 433372 [Multi-domain]  Cd Length: 230  Bit Score: 43.90  E-value: 5.46e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462564909  95 RSVALTISAYQEDpAYLRQCLASARALLYPRARLRVlmVVDGNRAEDLYMVDMFREVFADEDPATYVwdgnyhqpwepaa 174
Cdd:pfam13641   2 PDVSVVVPAFNED-SVLGRVLEAILAQPYPPVEVVV--VVNPSDAETLDVAEEIAARFPDVRLRVIR------------- 65

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462564909 175 agavgagayrevEAEDPGRlavealvrtrrcvcvaqrwGGKREVMYTAFKALGDsvDYVQVCDSDTRLDPMALLELVRVL 254
Cdd:pfam13641  66 ------------NARLLGP-------------------TGKSRGLNHGFRAVKS--DLVVLHDDDSVLHPGTLKKYVQYF 112

                         170       180       190
                  ....*....|....*....|....*....|.
gi 2462564909 255 DeDPRVGAVGGDVRILNPlDSWVSFLSSLRY 285
Cdd:pfam13641 113 D-SPKVGAVGTPVFSLNR-STMLSALGALEF 141
GT_2_like_c cd04186
Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse ...
 231-267 7.54e-05

Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.


Pssm-ID: 133029 [Multi-domain]  Cd Length: 166  Bit Score: 42.55  E-value: 7.54e-05
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 2462564909 231 DYVQVCDSDTRLDPMALLELVRVLDEDPRVGAVGGDV 267
Cdd:cd04186    76 DYVLLLNPDTVVEPGALLELLDAAEQDPDVGIVGPKV 112
CESA_CelA_like cd06421
CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Family of ...
 95-140 6.45e-04

CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Family of proteins related to Agrobacterium tumefaciens CelA and Gluconacetobacter xylinus BscA. These proteins are involved in the elongation of the glucan chain of cellulose, an aggregate of unbranched polymers of beta-1,4-linked glucose residues. They are putative catalytic subunit of cellulose synthase, which is a glycosyltransferase using UDP-glucose as the substrate. The catalytic subunit is an integral membrane protein with 6 transmembrane segments and it is postulated that the protein is anchored in the membrane at the N-terminal end.


Pssm-ID: 133043 [Multi-domain]  Cd Length: 234  Bit Score: 40.63  E-value: 6.45e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 2462564909  95 RSVALTISAYQEDPAYLRQCLASARALLYPRARLRVLMVVDGNRAE 140
Cdd:cd06421     1 PTVDVFIPTYNEPLEIVRKTLRAALAIDYPHDKLRVYVLDDGRRPE 46
GlcNAc-1-P_transferase cd06436
N-acetyl-glucosamine transferase is involved in the synthesis of Poly-beta-1, ...
 233-303 9.61e-04

N-acetyl-glucosamine transferase is involved in the synthesis of Poly-beta-1,6-N-acetyl-D-glucosamine; N-acetyl-glucosamine transferase is responsible for the synthesis of bacteria Poly-beta-1,6-N-acetyl-D-glucosamine (PGA). Poly-beta-1,6-N-acetyl-D-glucosamine is a homopolymer that serves as an adhesion for the maintenance of biofilm structural stability in diverse eubacteria. N-acetyl-glucosamine transferase is the product of gene pgaC. Genetic analysis indicated that all four genes of the pgaABCD locus were required for the PGA production, pgaC being a glycosyltransferase.


Pssm-ID: 133058 [Multi-domain]  Cd Length: 191  Bit Score: 39.67  E-value: 9.61e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462564909 233 VQVCDSDTRLDPMALlELVRVLDEDPRVGAVGGDVRILNPLDSWVSFLSSLRYWVAFNVERACQSYFHCVS 303
Cdd:cd06436    93 IAVIDADGRLDPNAL-EAVAPYFSDPRVAGTQSRVRMYNRHKNLLTILQDLEFFIIIAATQSLRALTGTVG 162
Glyco_tranf_GTA_type cd00761
Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a ...
 203-270 2.63e-03

Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Glycosyltransferases (GTs) are enzymes that synthesize oligosaccharides, polysaccharides, and glycoconjugates by transferring the sugar moiety from an activated nucleotide-sugar donor to an acceptor molecule, which may be a growing oligosaccharide, a lipid, or a protein. Based on the stereochemistry of the donor and acceptor molecules, GTs are classified as either retaining or inverting enzymes. To date, all GT structures adopt one of two possible folds, termed GT-A fold and GT-B fold. This hierarchy includes diverse families of glycosyl transferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. The majority of the proteins in this superfamily are Glycosyltransferase family 2 (GT-2) proteins. But it also includes families GT-43, GT-6, GT-8, GT13 and GT-7; which are evolutionarily related to GT-2 and share structure similarities.


Pssm-ID: 132997 [Multi-domain]  Cd Length: 156  Bit Score: 37.87  E-value: 2.63e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2462564909 203 RRCVCVAQRWGGKREVMYTAFKALgdSVDYVQVCDSDTRLDPMALLELVRVLDEDPRVGAVGGDVRIL 270
Cdd:cd00761    53 RVIRVINEENQGLAAARNAGLKAA--RGEYILFLDADDLLLPDWLERLVAELLADPEADAVGGPGNLL 118
EpsO_like cd06438
EpsO protein participates in the methanolan synthesis; The Methylobacillus sp EpsO protein is ...
 224-287 3.40e-03

EpsO protein participates in the methanolan synthesis; The Methylobacillus sp EpsO protein is predicted to participate in the methanolan synthesis. Methanolan is an exopolysaccharide (EPS), composed of glucose, mannose and galactose. A 21 genes cluster was predicted to participate in the methanolan synthesis. Gene disruption analysis revealed that EpsO is one of the glycosyltransferase enzymes involved in the synthesis of repeating sugar units onto the lipid carrier.


Pssm-ID: 133060 [Multi-domain]  Cd Length: 183  Bit Score: 37.97  E-value: 3.40e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2462564909 224 KALGDSVDYVQVCDSDTRLDPMALLELVRVLDEDPRVgaVGGDVRILNPLDSWVSFLSSLRYWV 287
Cdd:cd06438    76 LNLADDPDAVVVFDADNLVDPNALEELNARFAAGARV--VQAYYNSKNPDDSWITRLYAFAFLV 137
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH