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Conserved domains on  [gi|2462567413|ref|XP_054177976|]
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zinc finger protein 121 isoform X1 [Homo sapiens]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 11472214)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940
SCOP:  4003583

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
226-388 1.14e-09

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 59.71  E-value: 1.14e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462567413 226 KPYECNECGKAYNRFYLLTEHFKT--HTEE--KPFECKV--CGKSFRSSSCLKNHFRIHTGIKPYKCK--ECGKAFTVSS 297
Cdd:COG5048   288 LPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKllNSSSKFSPLL 367

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462567413 298 ------SLHNHVKIHTgEKPYEC--KDCGKAFATSSQLIEHIRTHTGEKPY--ICKECGKTFRASSHLQKHVRIHTgEKP 367
Cdd:COG5048   368 nneppqSLQQYKDLKN-DKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYncKNPPCSKSFNRHYNLIPHKKIHT-NHA 445

                         170       180
                  ....*....|....*....|.
gi 2462567413 368 YICNECGKAYNRFYLLTKHLK 388
Cdd:COG5048   446 PLLCSILKSFRRDLDLSNHGK 466
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
85-270 1.37e-05

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 47.00  E-value: 1.37e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462567413  85 DKSFEYSDCEEAFVDQSHLQANRITHNGETL-YEQKQCGRAFTYSTSHA--VSVKMHTVE--KPYECKE--CGKFFRYSS 157
Cdd:COG5048   258 SESPRSSLPTASSQSSSPNESDSSSEKGFSLpIKSKQCNISFSRSSPLTrhLRSVNHSGEslKPFSCPYslCGKLFSRND 337

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462567413 158 YLNSHMRTHTGEKPYECK--ECGKCFTVSSH--LVEHVRIHTGEKPYQCKE-----CGRAFAGRSGLTKHVRIHTGEKPY 228
Cdd:COG5048   338 ALKRHILLHTSISPAKEKllNSSSKFSPLLNnePPQSLQQYKDLKNDKKSEtlsnsCIRNFKRDSNLSLHIITHLSFRPY 417

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 2462567413 229 ECN--ECGKAYNRFYLLTEHFKTHTEEKPFECKVCGKSFRSSSC 270
Cdd:COG5048   418 NCKnpPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDL 461
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
226-388 1.14e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 59.71  E-value: 1.14e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462567413 226 KPYECNECGKAYNRFYLLTEHFKT--HTEE--KPFECKV--CGKSFRSSSCLKNHFRIHTGIKPYKCK--ECGKAFTVSS 297
Cdd:COG5048   288 LPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKllNSSSKFSPLL 367

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462567413 298 ------SLHNHVKIHTgEKPYEC--KDCGKAFATSSQLIEHIRTHTGEKPY--ICKECGKTFRASSHLQKHVRIHTgEKP 367
Cdd:COG5048   368 nneppqSLQQYKDLKN-DKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYncKNPPCSKSFNRHYNLIPHKKIHT-NHA 445

                         170       180
                  ....*....|....*....|.
gi 2462567413 368 YICNECGKAYNRFYLLTKHLK 388
Cdd:COG5048   446 PLLCSILKSFRRDLDLSNHGK 466
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
85-270 1.37e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 47.00  E-value: 1.37e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462567413  85 DKSFEYSDCEEAFVDQSHLQANRITHNGETL-YEQKQCGRAFTYSTSHA--VSVKMHTVE--KPYECKE--CGKFFRYSS 157
Cdd:COG5048   258 SESPRSSLPTASSQSSSPNESDSSSEKGFSLpIKSKQCNISFSRSSPLTrhLRSVNHSGEslKPFSCPYslCGKLFSRND 337

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462567413 158 YLNSHMRTHTGEKPYECK--ECGKCFTVSSH--LVEHVRIHTGEKPYQCKE-----CGRAFAGRSGLTKHVRIHTGEKPY 228
Cdd:COG5048   338 ALKRHILLHTSISPAKEKllNSSSKFSPLLNnePPQSLQQYKDLKNDKKSEtlsnsCIRNFKRDSNLSLHIITHLSFRPY 417

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 2462567413 229 ECN--ECGKAYNRFYLLTEHFKTHTEEKPFECKVCGKSFRSSSC 270
Cdd:COG5048   418 NCKnpPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDL 461
zf-H2C2_2 pfam13465
Zinc-finger double domain;
158-182 8.04e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.28  E-value: 8.04e-05
                          10        20
                  ....*....|....*....|....*
gi 2462567413 158 YLNSHMRTHTGEKPYECKECGKCFT 182
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
271-294 6.00e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 6.00e-04
                          10        20
                  ....*....|....*....|....
gi 2462567413 271 LKNHFRIHTGIKPYKCKECGKAFT 294
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFK 25
PHA00733 PHA00733
hypothetical protein
 311-359 4.05e-03

hypothetical protein


Pssm-ID: 177301  Cd Length: 128  Bit Score: 37.16  E-value: 4.05e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 2462567413 311 PYECKDCGKAFATSSQLIEHIRTHTGEKpyICKECGKTFRASSHLQKHV 359
Cdd:PHA00733   73 PYVCPLCLMPFSSSVSLKQHIRYTEHSK--VCPVCGKEFRNTDSTLDHV 119
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
226-388 1.14e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 59.71  E-value: 1.14e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462567413 226 KPYECNECGKAYNRFYLLTEHFKT--HTEE--KPFECKV--CGKSFRSSSCLKNHFRIHTGIKPYKCK--ECGKAFTVSS 297
Cdd:COG5048   288 LPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKllNSSSKFSPLL 367

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462567413 298 ------SLHNHVKIHTgEKPYEC--KDCGKAFATSSQLIEHIRTHTGEKPY--ICKECGKTFRASSHLQKHVRIHTgEKP 367
Cdd:COG5048   368 nneppqSLQQYKDLKN-DKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYncKNPPCSKSFNRHYNLIPHKKIHT-NHA 445

                         170       180
                  ....*....|....*....|.
gi 2462567413 368 YICNECGKAYNRFYLLTKHLK 388
Cdd:COG5048   446 PLLCSILKSFRRDLDLSNHGK 466
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
170-325 2.72e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 52.39  E-value: 2.72e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462567413 170 KPYECKECGKCFTVSSHLVEHVR--IHTGE--KPYQCKE--CGRAFAGRSGLTKHVRIHTGEKPYECNEC-------GKA 236
Cdd:COG5048   288 LPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKLLnssskfsPLL 367

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462567413 237 YNRFYLLTEHFKTHTEEKPFECKV--CGKSFRSSSCLKNHFRIHT--GIKPYKCKECGKAFTVSSSLHNHVKIHTGEKPY 312
Cdd:COG5048   368 NNEPPQSLQQYKDLKNDKKSETLSnsCIRNFKRDSNLSLHIITHLsfRPYNCKNPPCSKSFNRHYNLIPHKKIHTNHAPL 447

                         170
                  ....*....|...
gi 2462567413 313 ECKDCGKAFATSS 325
Cdd:COG5048   448 LCSILKSFRRDLD 460
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
198-358 2.76e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 49.31  E-value: 2.76e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462567413 198 KPYQCKECGRAFAGRSGLTKHVR--IHTGE--KPYECNE--CGKAYNRFYLLTEHFKTHTEEKPFECKVCGKSFRSSSCL 271
Cdd:COG5048   288 LPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLL 367

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462567413 272 KN----HFRIHTGIKPYKCKEC----GKAFTVS---SSLHNHVKIHTGEKPYECKDCGKAFATSSQLIEHIRTHTgEKPY 340
Cdd:COG5048   368 NNeppqSLQQYKDLKNDKKSETlsnsCIRNFKRdsnLSLHIITHLSFRPYNCKNPPCSKSFNRHYNLIPHKKIHT-NHAP 446

                         170
                  ....*....|....*...
gi 2462567413 341 ICKECGKTFRASSHLQKH 358
Cdd:COG5048   447 LLCSILKSFRRDLDLSNH 464
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
85-270 1.37e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 47.00  E-value: 1.37e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462567413  85 DKSFEYSDCEEAFVDQSHLQANRITHNGETL-YEQKQCGRAFTYSTSHA--VSVKMHTVE--KPYECKE--CGKFFRYSS 157
Cdd:COG5048   258 SESPRSSLPTASSQSSSPNESDSSSEKGFSLpIKSKQCNISFSRSSPLTrhLRSVNHSGEslKPFSCPYslCGKLFSRND 337

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462567413 158 YLNSHMRTHTGEKPYECK--ECGKCFTVSSH--LVEHVRIHTGEKPYQCKE-----CGRAFAGRSGLTKHVRIHTGEKPY 228
Cdd:COG5048   338 ALKRHILLHTSISPAKEKllNSSSKFSPLLNnePPQSLQQYKDLKNDKKSEtlsnsCIRNFKRDSNLSLHIITHLSFRPY 417

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 2462567413 229 ECN--ECGKAYNRFYLLTEHFKTHTEEKPFECKVCGKSFRSSSC 270
Cdd:COG5048   418 NCKnpPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDL 461
zf-H2C2_2 pfam13465
Zinc-finger double domain;
158-182 8.04e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.28  E-value: 8.04e-05
                          10        20
                  ....*....|....*....|....*
gi 2462567413 158 YLNSHMRTHTGEKPYECKECGKCFT 182
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
170-279 2.59e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 42.76  E-value: 2.59e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462567413 170 KPYECKECGKCFTVSSHLVEHVRIHTGEKPYQCKECGRA--FAGRSGLTKHVRIHTGEKPYEC----------------N 231
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDksFSRPLELSRHLRTHHNNPSDLNskslplsnskasssslS 111

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 2462567413 232 ECGKAYNRFYLLTEHFKTHTEEKPFECKVCGKSFRSSSCLKNHFRIHT 279
Cdd:COG5048   112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSV 159
zf-H2C2_2 pfam13465
Zinc-finger double domain;
186-210 6.00e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 6.00e-04
                          10        20
                  ....*....|....*....|....*
gi 2462567413 186 HLVEHVRIHTGEKPYQCKECGRAFA 210
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
271-294 6.00e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 6.00e-04
                          10        20
                  ....*....|....*....|....
gi 2462567413 271 LKNHFRIHTGIKPYKCKECGKAFT 294
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
215-239 1.18e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.18e-03
                          10        20
                  ....*....|....*....|....*
gi 2462567413 215 LTKHVRIHTGEKPYECNECGKAYNR 239
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
302-323 2.24e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 2.24e-03
                          10        20
                  ....*....|....*....|..
gi 2462567413 302 HVKIHTGEKPYECKDCGKAFAT 323
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
354-379 3.31e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 3.31e-03
                          10        20
                  ....*....|....*....|....*.
gi 2462567413 354 HLQKHVRIHTGEKPYICNECGKAYNR 379
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
282-339 3.36e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 39.29  E-value: 3.36e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462567413 282 KPYKCKECGKAFTVSSSLHNHVKIHTGEKPYECKD--CGKAFATSSQLIEHIRTHTGEKP 339
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPS 91
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 312-334 3.54e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.58  E-value: 3.54e-03
                          10        20
                  ....*....|....*....|...
gi 2462567413 312 YECKDCGKAFATSSQLIEHIRTH 334
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
243-267 3.77e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 3.77e-03
                          10        20
                  ....*....|....*....|....*
gi 2462567413 243 LTEHFKTHTEEKPFECKVCGKSFRS 267
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 144-166 3.87e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.58  E-value: 3.87e-03
                          10        20
                  ....*....|....*....|...
gi 2462567413 144 YECKECGKFFRYSSYLNSHMRTH 166
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
PHA00733 PHA00733
hypothetical protein
 311-359 4.05e-03

hypothetical protein


Pssm-ID: 177301  Cd Length: 128  Bit Score: 37.16  E-value: 4.05e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 2462567413 311 PYECKDCGKAFATSSQLIEHIRTHTGEKpyICKECGKTFRASSHLQKHV 359
Cdd:PHA00733   73 PYVCPLCLMPFSSSVSLKQHIRYTEHSK--VCPVCGKEFRNTDSTLDHV 119
PHA00733 PHA00733
hypothetical protein
 255-303 4.17e-03

hypothetical protein


Pssm-ID: 177301  Cd Length: 128  Bit Score: 37.16  E-value: 4.17e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 2462567413 255 PFECKVCGKSFRSSSCLKNHFRIHTGIKpyKCKECGKAFTVSSSLHNHV 303
Cdd:PHA00733   73 PYVCPLCLMPFSSSVSLKQHIRYTEHSK--VCPVCGKEFRNTDSTLDHV 119
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
254-319 6.31e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 38.52  E-value: 6.31e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2462567413 254 KPFECKVCGKSFRSSSCLKNHFRIHTGIKPYKC--KECGKAFTVSSSLHNHVKIHTGEKPYECKDCGK 319
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLP 99
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
310-371 6.94e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 38.52  E-value: 6.94e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2462567413 310 KPYECKDCGKAFATSSQLIEHIRTHTGEKPYIC--KECGKTFRASSHLQKHVRIHTGEKPYICN 371
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNS 95
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
338-390 8.13e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 38.14  E-value: 8.13e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2462567413 338 KPYICKECGKTFRASSHLQKHVRIHTGEKPYICN--ECGKAYNRFYLLTKHLKTH 390
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTH 86
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 340-362 9.82e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 33.43  E-value: 9.82e-03
                          10        20
                  ....*....|....*....|...
gi 2462567413 340 YICKECGKTFRASSHLQKHVRIH 362
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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