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Conserved domains on  [gi|2462579527|ref|XP_054179012|]
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RIPOR family member 3 isoform X8 [Homo sapiens]

Protein Classification

RIPOR family protein( domain architecture ID 11239740)

RIPOR family protein similar to human Rho family-interacting cell polarization regulator 2 (RIPOR2) that acts as an inhibitor of the small GTPase RHOA and plays several roles in the regulation of myoblast and hair cell differentiation, lymphocyte T proliferation and neutrophil polarization

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PL48 pfam15903
Filopodia upregulated, FAM65; PL48 is associated with cytotrophoblast and lineage-specific ...
 23-367 0e+00

Filopodia upregulated, FAM65; PL48 is associated with cytotrophoblast and lineage-specific HL-60 cell differentiation. The N-terminal part of the family is found to induce the formation of filopodia. It is found in vertebrates.


:

Pssm-ID: 464930  Cd Length: 297  Bit Score: 557.40  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462579527  23 VGRSASFAGFSSAQSRRIAKSINRNSVRSRMPAKSSKMY-GTLRKGSVCADPKPQQVKKIFEALKRGLKEYLCVQQAELD 101
Cdd:pfam15903   1 ITRSQSFAGFSSAQERRNLSSFSRPSLRSKPPSKSSRMFtSSHKSGPPPKVPQPERVDRVYEALKKGLKEYLEVHQAELD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462579527 102 HLSGRHKDTRRNSRLAFYYDLDKQTRCVERHIRKMEFHISKvdelyedyciqcrlrdgassmqrafarcppsraareslq 181
Cdd:pfam15903  81 KLSRQQKDTKRNSRLGFLYDLDKQIKSVERYIRRLEFHISK--------------------------------------- 121

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462579527 182 elgrslhecaeDMWLIEGALEVHLGEFHIRMKGLVGYARLCPGDHYEVLMRLGRQRWKLKGRIESDDSQTWDEEEKAFIP 261
Cdd:pfam15903 122 -----------DMCLLEGELENLLGEFHIKMKGLAGFARLCPGDQYEVLMRYGRQRWKLRGRIETDDKQVWDEEEMVFLP 190

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462579527 262 TLHENLDIKVTELRGLGS-LAVGAVTCDIADFFTTRPQVIVVDITELGTIKLQLEVQWNPFDTESFLVSPSPTGKFSMGS 340
Cdd:pfam15903 191 LIHENFEIKVTELKGLANhVLVGSVTCETKDLFAARPQVVAVDINDLGTIKLQLEVTWNPFDKEDQLPSASSVSKASVVS 270

                         330       340
                  ....*....|....*....|....*..
gi 2462579527 341 RKGSLYNWTPPSTPSFRERYYLSVLQQ 367
Cdd:pfam15903 271 RRGSVYSWTPPDTPSFREKYFLSMLRQ 297
 
Name Accession Description Interval E-value
PL48 pfam15903
Filopodia upregulated, FAM65; PL48 is associated with cytotrophoblast and lineage-specific ...
 23-367 0e+00

Filopodia upregulated, FAM65; PL48 is associated with cytotrophoblast and lineage-specific HL-60 cell differentiation. The N-terminal part of the family is found to induce the formation of filopodia. It is found in vertebrates.


Pssm-ID: 464930  Cd Length: 297  Bit Score: 557.40  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462579527  23 VGRSASFAGFSSAQSRRIAKSINRNSVRSRMPAKSSKMY-GTLRKGSVCADPKPQQVKKIFEALKRGLKEYLCVQQAELD 101
Cdd:pfam15903   1 ITRSQSFAGFSSAQERRNLSSFSRPSLRSKPPSKSSRMFtSSHKSGPPPKVPQPERVDRVYEALKKGLKEYLEVHQAELD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462579527 102 HLSGRHKDTRRNSRLAFYYDLDKQTRCVERHIRKMEFHISKvdelyedyciqcrlrdgassmqrafarcppsraareslq 181
Cdd:pfam15903  81 KLSRQQKDTKRNSRLGFLYDLDKQIKSVERYIRRLEFHISK--------------------------------------- 121

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462579527 182 elgrslhecaeDMWLIEGALEVHLGEFHIRMKGLVGYARLCPGDHYEVLMRLGRQRWKLKGRIESDDSQTWDEEEKAFIP 261
Cdd:pfam15903 122 -----------DMCLLEGELENLLGEFHIKMKGLAGFARLCPGDQYEVLMRYGRQRWKLRGRIETDDKQVWDEEEMVFLP 190

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462579527 262 TLHENLDIKVTELRGLGS-LAVGAVTCDIADFFTTRPQVIVVDITELGTIKLQLEVQWNPFDTESFLVSPSPTGKFSMGS 340
Cdd:pfam15903 191 LIHENFEIKVTELKGLANhVLVGSVTCETKDLFAARPQVVAVDINDLGTIKLQLEVTWNPFDKEDQLPSASSVSKASVVS 270

                         330       340
                  ....*....|....*....|....*..
gi 2462579527 341 RKGSLYNWTPPSTPSFRERYYLSVLQQ 367
Cdd:pfam15903 271 RRGSVYSWTPPDTPSFREKYFLSMLRQ 297
 
Name Accession Description Interval E-value
PL48 pfam15903
Filopodia upregulated, FAM65; PL48 is associated with cytotrophoblast and lineage-specific ...
 23-367 0e+00

Filopodia upregulated, FAM65; PL48 is associated with cytotrophoblast and lineage-specific HL-60 cell differentiation. The N-terminal part of the family is found to induce the formation of filopodia. It is found in vertebrates.


Pssm-ID: 464930  Cd Length: 297  Bit Score: 557.40  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462579527  23 VGRSASFAGFSSAQSRRIAKSINRNSVRSRMPAKSSKMY-GTLRKGSVCADPKPQQVKKIFEALKRGLKEYLCVQQAELD 101
Cdd:pfam15903   1 ITRSQSFAGFSSAQERRNLSSFSRPSLRSKPPSKSSRMFtSSHKSGPPPKVPQPERVDRVYEALKKGLKEYLEVHQAELD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462579527 102 HLSGRHKDTRRNSRLAFYYDLDKQTRCVERHIRKMEFHISKvdelyedyciqcrlrdgassmqrafarcppsraareslq 181
Cdd:pfam15903  81 KLSRQQKDTKRNSRLGFLYDLDKQIKSVERYIRRLEFHISK--------------------------------------- 121

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462579527 182 elgrslhecaeDMWLIEGALEVHLGEFHIRMKGLVGYARLCPGDHYEVLMRLGRQRWKLKGRIESDDSQTWDEEEKAFIP 261
Cdd:pfam15903 122 -----------DMCLLEGELENLLGEFHIKMKGLAGFARLCPGDQYEVLMRYGRQRWKLRGRIETDDKQVWDEEEMVFLP 190

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462579527 262 TLHENLDIKVTELRGLGS-LAVGAVTCDIADFFTTRPQVIVVDITELGTIKLQLEVQWNPFDTESFLVSPSPTGKFSMGS 340
Cdd:pfam15903 191 LIHENFEIKVTELKGLANhVLVGSVTCETKDLFAARPQVVAVDINDLGTIKLQLEVTWNPFDKEDQLPSASSVSKASVVS 270

                         330       340
                  ....*....|....*....|....*..
gi 2462579527 341 RKGSLYNWTPPSTPSFRERYYLSVLQQ 367
Cdd:pfam15903 271 RRGSVYSWTPPDTPSFREKYFLSMLRQ 297
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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