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Conserved domains on  [gi|2462585569|ref|XP_054181942|]
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clathrin heavy chain 2 isoform X14 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CLH smart00299
Clathrin heavy chain repeat homology;
921-1061 9.43e-33

Clathrin heavy chain repeat homology;


:

Pssm-ID: 128594 [Multi-domain]  Cd Length: 140  Bit Score: 124.31  E-value: 9.43e-33
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462585569   921 LSETRDPEEISVTVKAFMTADLPNELIELLEKIVLDNSvfsEHRNLQNLLILTAIKADRTRVMEYISR-LDNYDALDIAS 999
Cdd:smart00299    1 LLEVSDPIDVSEVVELFEKRNLLEELIPYLESALKLNS---ENPALQTKLIELYAKYDPQKEIERLDNkSNHYDIEKVGK 77

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462585569  1000 IAVSSALYEEAFTVFHKFDMNASAIQVLIEHIGNLDRAYEFAERCNEPAVWSQLAQAQLQKD 1061
Cdd:smart00299   78 LCEKAKLYEEAVELYKKDGNFKDAIVTLIEHLGNYEKAIEYFVKQNNPELWAEVLKALLDKP 139
CLH smart00299
Clathrin heavy chain repeat homology;
628-766 2.09e-32

Clathrin heavy chain repeat homology;


:

Pssm-ID: 128594 [Multi-domain]  Cd Length: 140  Bit Score: 123.15  E-value: 2.09e-32
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462585569   628 ASKYHEQLGTQALVELFESFKSYKGLFYFLGSIVNF-SQDPDVHLKYIQAACKTGQIKEVERICRESSCYNPERVKNFLK 706
Cdd:smart00299    1 LLEVSDPIDVSEVVELFEKRNLLEELIPYLESALKLnSENPALQTKLIELYAKYDPQKEIERLDNKSNHYDIEKVGKLCE 80

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462585569   707 EAKLTDQLPLIIVCDRFgFVHDLVLYLYR-NNLQRYIEIYVQKVNPSRTPAVIGGLLDVDC 766
Cdd:smart00299   81 KAKLYEEAVELYKKDGN-FKDAIVTLIEHlGNYEKAIEYFVKQNNPELWAEVLKALLDKPR 140
Clathrin pfam00637
Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are ...
 1070-1209 1.94e-29

Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are composed of multiple alpha helical repeats. They occur in the arm region of the Clathrin heavy chain.


:

Pssm-ID: 459884 [Multi-domain]  Cd Length: 142  Bit Score: 114.66  E-value: 1.94e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462585569 1070 YIRGDDPSSYLEVVQSASRSNNWEDLVKFLQMARKKGRE--SYIETELIFALAKTSRVSELEDFINGPNNAHIQQVGDRC 1147
Cdd:pfam00637    1 LIESTDPIDVSRVVKLFEKAGLLEELISYLESALKEDSRenPALQTALIELYAKYDDPEELEEFLKKNNNYDLEKVAKLC 80

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462585569 1148 YEEGMYEAAKLLYSNVSNFARLASTLVHLGEYQAAVDNSRKASSTRTWKEVCFACMDGQEFR 1209
Cdd:pfam00637   81 EKADLYEEAVILYKKIGNWKEAISLLKKLGDYKDAIEYAVKSSNPELWEELLEALLDNGRFE 142
CLH smart00299
Clathrin heavy chain repeat homology;
483-616 1.00e-28

Clathrin heavy chain repeat homology;


:

Pssm-ID: 128594 [Multi-domain]  Cd Length: 140  Bit Score: 112.75  E-value: 1.00e-28
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462585569   483 EPLANISQIVDIFMENSLIQQCTSFLLDALKNNrPAEGLLQTWLLEMNLVHAPQVADAILGNkMFTHYDRAHIAQLCEKA 562
Cdd:smart00299    5 SDPIDVSEVVELFEKRNLLEELIPYLESALKLN-SENPALQTKLIELYAKYDPQKEIERLDN-KSNHYDIEKVGKLCEKA 82

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....*..
gi 2462585569   563 GLLQQALEHYTDLYDIKRAVVHT--HLLNPEWLVNFFGS-LSVEDSVECLHAMLSAN 616
Cdd:smart00299   83 KLYEEAVELYKKDGNFKDAIVTLieHLGNYEKAIEYFVKqNNPELWAEVLKALLDKP 139
CLH smart00299
Clathrin heavy chain repeat homology;
1216-1358 1.80e-28

Clathrin heavy chain repeat homology;


:

Pssm-ID: 128594 [Multi-domain]  Cd Length: 140  Bit Score: 111.98  E-value: 1.80e-28
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462585569  1216 LHIVIHADELEELMCYYQDRGYFEELILLLEAALGLERAHMGVFTELAILYSKFKPQKMLEHLELFWSRVNIPKVLRAAE 1295
Cdd:smart00299    1 LLEVSDPIDVSEVVELFEKRNLLEELIPYLESALKLNSENPALQTKLIELYAKYDPQKEIERLDNKSNHYDIEKVGKLCE 80

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462585569  1296 QAHLWAELVFLYDKYEEYDNAVLTMMSHPTEAwkeGQFKDIITKVANVELCYRALQFYLDYKP 1358
Cdd:smart00299   81 KAKLYEEAVELYKKDGNFKDAIVTLIEHLGNY---EKAIEYFVKQNNPELWAEVLKALLDKPR 140
CLH smart00299
Clathrin heavy chain repeat homology;
775-902 2.90e-27

Clathrin heavy chain repeat homology;


:

Pssm-ID: 128594 [Multi-domain]  Cd Length: 140  Bit Score: 108.52  E-value: 2.90e-27
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462585569   775 IMAVRGQFSTDELVAEVEKRNRLKLLLPWLESQIQEGCEEPATHNALAKIYIDSNNSP--ECFLRENAYYDSSVVGRYCE 852
Cdd:smart00299    1 LLEVSDPIDVSEVVELFEKRNLLEELIPYLESALKLNSENPALQTKLIELYAKYDPQKeiERLDNKSNHYDIEKVGKLCE 80

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|..
gi 2462585569   853 KRDPH-LACVAYERGQCDLELIKVCNENS-LFKSEARYLVCRKDPELWAHVL 902
Cdd:smart00299   81 KAKLYeEAVELYKKDGNFKDAIVTLIEHLgNYEKAIEYFVKQNNPELWAEVL 132
Clathrin_H_link pfam13838
Clathrin-H-link; This short domain is found on clathrins, and often appears on proteins ...
 298-363 9.67e-20

Clathrin-H-link; This short domain is found on clathrins, and often appears on proteins directly downstream from the Clathrin-link domain pfam09268.


:

Pssm-ID: 463995  Cd Length: 66  Bit Score: 84.18  E-value: 9.67e-20
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462585569  298 NLAGAEKLFVRKFNTLFAQGSYAEAAKVAASAPKGILRTRETVQKFQSIPAQSGQASPLLQYFGIL 363
Cdd:pfam13838    1 GLPGADDLYFQQFNQLLNQGDYAEAAKVAANSPRGALRTPETIQRFKQLPAQPGQLSPILQYFGTL 66
Clathrin-link pfam09268
Clathrin, heavy-chain linker; Members of this family adopt a structure consisting of ...
 273-296 5.88e-08

Clathrin, heavy-chain linker; Members of this family adopt a structure consisting of alpha-alpha superhelix. They are predominantly found in clathrin, where they act as a heavy-chain linker domain.


:

Pssm-ID: 462732  Cd Length: 24  Bit Score: 49.75  E-value: 5.88e-08
                           10        20
                   ....*....|....*....|....
gi 2462585569  273 EDNIVNYATNVLQNPDLGLRLAVR 296
Cdd:pfam09268    1 EDNIIPYILNTLQNPDLALRLASR 24
Clathrin_propel pfam01394
Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that ...
 198-234 8.53e-06

Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that surrounds coated vesicles. The soluble assembly unit, a triskelion, contains three heavy chains and three light chains in an extended three-legged structure. Each leg contains one heavy and one light chain. The N-terminus of the heavy chain is known as the globular domain, and is composed of seven repeats which form a beta propeller.


:

Pssm-ID: 460192  Cd Length: 37  Bit Score: 43.94  E-value: 8.53e-06
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 2462585569  198 AAAFAEFKMEGNAKPATLFCFAVRNPTGGKLHIIEVG 234
Cdd:pfam01394    1 NAISAIIIFPTATMESWLFIIAINGTKKGQVQIVDVE 37
Clathrin_propel pfam01394
Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that ...
 19-55 7.67e-04

Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that surrounds coated vesicles. The soluble assembly unit, a triskelion, contains three heavy chains and three light chains in an extended three-legged structure. Each leg contains one heavy and one light chain. The N-terminus of the heavy chain is known as the globular domain, and is composed of seven repeats which form a beta propeller.


:

Pssm-ID: 460192  Cd Length: 37  Bit Score: 38.17  E-value: 7.67e-04
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 2462585569   19 GINPANIGFSTLTMESDKFICIREKVGeQAQVTIIDM 55
Cdd:pfam01394    1 NAISAIIIFPTATMESWLFIIAINGTK-KGQVQIVDV 36
 
Name Accession Description Interval E-value
CLH smart00299
Clathrin heavy chain repeat homology;
921-1061 9.43e-33

Clathrin heavy chain repeat homology;


Pssm-ID: 128594 [Multi-domain]  Cd Length: 140  Bit Score: 124.31  E-value: 9.43e-33
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462585569   921 LSETRDPEEISVTVKAFMTADLPNELIELLEKIVLDNSvfsEHRNLQNLLILTAIKADRTRVMEYISR-LDNYDALDIAS 999
Cdd:smart00299    1 LLEVSDPIDVSEVVELFEKRNLLEELIPYLESALKLNS---ENPALQTKLIELYAKYDPQKEIERLDNkSNHYDIEKVGK 77

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462585569  1000 IAVSSALYEEAFTVFHKFDMNASAIQVLIEHIGNLDRAYEFAERCNEPAVWSQLAQAQLQKD 1061
Cdd:smart00299   78 LCEKAKLYEEAVELYKKDGNFKDAIVTLIEHLGNYEKAIEYFVKQNNPELWAEVLKALLDKP 139
CLH smart00299
Clathrin heavy chain repeat homology;
628-766 2.09e-32

Clathrin heavy chain repeat homology;


Pssm-ID: 128594 [Multi-domain]  Cd Length: 140  Bit Score: 123.15  E-value: 2.09e-32
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462585569   628 ASKYHEQLGTQALVELFESFKSYKGLFYFLGSIVNF-SQDPDVHLKYIQAACKTGQIKEVERICRESSCYNPERVKNFLK 706
Cdd:smart00299    1 LLEVSDPIDVSEVVELFEKRNLLEELIPYLESALKLnSENPALQTKLIELYAKYDPQKEIERLDNKSNHYDIEKVGKLCE 80

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462585569   707 EAKLTDQLPLIIVCDRFgFVHDLVLYLYR-NNLQRYIEIYVQKVNPSRTPAVIGGLLDVDC 766
Cdd:smart00299   81 KAKLYEEAVELYKKDGN-FKDAIVTLIEHlGNYEKAIEYFVKQNNPELWAEVLKALLDKPR 140
Clathrin pfam00637
Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are ...
 921-1061 4.12e-30

Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are composed of multiple alpha helical repeats. They occur in the arm region of the Clathrin heavy chain.


Pssm-ID: 459884 [Multi-domain]  Cd Length: 142  Bit Score: 116.59  E-value: 4.12e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462585569  921 LSETRDPEEISVTVKAFMTADLPNELIELLEKIVLDNSvfSEHRNLQNLLILTAIKADR-TRVMEYISRLDNYDALDIAS 999
Cdd:pfam00637    1 LIESTDPIDVSRVVKLFEKAGLLEELISYLESALKEDS--RENPALQTALIELYAKYDDpEELEEFLKKNNNYDLEKVAK 78

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462585569 1000 IAVSSALYEEAFTVFHKFDMNASAIqVLIEHIGNLDRAYEFAERCNEPAVWSQLAQAQLQKD 1061
Cdd:pfam00637   79 LCEKADLYEEAVILYKKIGNWKEAI-SLLKKLGDYKDAIEYAVKSSNPELWEELLEALLDNG 139
Clathrin pfam00637
Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are ...
 1070-1209 1.94e-29

Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are composed of multiple alpha helical repeats. They occur in the arm region of the Clathrin heavy chain.


Pssm-ID: 459884 [Multi-domain]  Cd Length: 142  Bit Score: 114.66  E-value: 1.94e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462585569 1070 YIRGDDPSSYLEVVQSASRSNNWEDLVKFLQMARKKGRE--SYIETELIFALAKTSRVSELEDFINGPNNAHIQQVGDRC 1147
Cdd:pfam00637    1 LIESTDPIDVSRVVKLFEKAGLLEELISYLESALKEDSRenPALQTALIELYAKYDDPEELEEFLKKNNNYDLEKVAKLC 80

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462585569 1148 YEEGMYEAAKLLYSNVSNFARLASTLVHLGEYQAAVDNSRKASSTRTWKEVCFACMDGQEFR 1209
Cdd:pfam00637   81 EKADLYEEAVILYKKIGNWKEAISLLKKLGDYKDAIEYAVKSSNPELWEELLEALLDNGRFE 142
CLH smart00299
Clathrin heavy chain repeat homology;
1070-1207 2.44e-29

Clathrin heavy chain repeat homology;


Pssm-ID: 128594 [Multi-domain]  Cd Length: 140  Bit Score: 114.29  E-value: 2.44e-29
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462585569  1070 YIRGDDPSSYLEVVQSASRSNNWEDLVKFLQMARKKGRE-SYIETELIFALAKTSRVSELEDFINGPNNAHIQQVGDRCY 1148
Cdd:smart00299    1 LLEVSDPIDVSEVVELFEKRNLLEELIPYLESALKLNSEnPALQTKLIELYAKYDPQKEIERLDNKSNHYDIEKVGKLCE 80

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462585569  1149 EEGMYEAAKLLYSNVSNFARLASTLV-HLGEYQAAVDNSRKASSTRTWKEVCFACMDGQE 1207
Cdd:smart00299   81 KAKLYEEAVELYKKDGNFKDAIVTLIeHLGNYEKAIEYFVKQNNPELWAEVLKALLDKPR 140
CLH smart00299
Clathrin heavy chain repeat homology;
483-616 1.00e-28

Clathrin heavy chain repeat homology;


Pssm-ID: 128594 [Multi-domain]  Cd Length: 140  Bit Score: 112.75  E-value: 1.00e-28
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462585569   483 EPLANISQIVDIFMENSLIQQCTSFLLDALKNNrPAEGLLQTWLLEMNLVHAPQVADAILGNkMFTHYDRAHIAQLCEKA 562
Cdd:smart00299    5 SDPIDVSEVVELFEKRNLLEELIPYLESALKLN-SENPALQTKLIELYAKYDPQKEIERLDN-KSNHYDIEKVGKLCEKA 82

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....*..
gi 2462585569   563 GLLQQALEHYTDLYDIKRAVVHT--HLLNPEWLVNFFGS-LSVEDSVECLHAMLSAN 616
Cdd:smart00299   83 KLYEEAVELYKKDGNFKDAIVTLieHLGNYEKAIEYFVKqNNPELWAEVLKALLDKP 139
CLH smart00299
Clathrin heavy chain repeat homology;
1216-1358 1.80e-28

Clathrin heavy chain repeat homology;


Pssm-ID: 128594 [Multi-domain]  Cd Length: 140  Bit Score: 111.98  E-value: 1.80e-28
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462585569  1216 LHIVIHADELEELMCYYQDRGYFEELILLLEAALGLERAHMGVFTELAILYSKFKPQKMLEHLELFWSRVNIPKVLRAAE 1295
Cdd:smart00299    1 LLEVSDPIDVSEVVELFEKRNLLEELIPYLESALKLNSENPALQTKLIELYAKYDPQKEIERLDNKSNHYDIEKVGKLCE 80

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462585569  1296 QAHLWAELVFLYDKYEEYDNAVLTMMSHPTEAwkeGQFKDIITKVANVELCYRALQFYLDYKP 1358
Cdd:smart00299   81 KAKLYEEAVELYKKDGNFKDAIVTLIEHLGNY---EKAIEYFVKQNNPELWAEVLKALLDKPR 140
CLH smart00299
Clathrin heavy chain repeat homology;
775-902 2.90e-27

Clathrin heavy chain repeat homology;


Pssm-ID: 128594 [Multi-domain]  Cd Length: 140  Bit Score: 108.52  E-value: 2.90e-27
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462585569   775 IMAVRGQFSTDELVAEVEKRNRLKLLLPWLESQIQEGCEEPATHNALAKIYIDSNNSP--ECFLRENAYYDSSVVGRYCE 852
Cdd:smart00299    1 LLEVSDPIDVSEVVELFEKRNLLEELIPYLESALKLNSENPALQTKLIELYAKYDPQKeiERLDNKSNHYDIEKVGKLCE 80

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|..
gi 2462585569   853 KRDPH-LACVAYERGQCDLELIKVCNENS-LFKSEARYLVCRKDPELWAHVL 902
Cdd:smart00299   81 KAKLYeEAVELYKKDGNFKDAIVTLIEHLgNYEKAIEYFVKQNNPELWAEVL 132
Clathrin pfam00637
Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are ...
 630-768 4.49e-25

Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are composed of multiple alpha helical repeats. They occur in the arm region of the Clathrin heavy chain.


Pssm-ID: 459884 [Multi-domain]  Cd Length: 142  Bit Score: 102.33  E-value: 4.49e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462585569  630 KYHEQLGTQALVELFESFKSYKGLFYFLGSIVNFS--QDPDVHLKYIQAACKTGQIKEVERICRESSCYNPERVKNFLKE 707
Cdd:pfam00637    3 ESTDPIDVSRVVKLFEKAGLLEELISYLESALKEDsrENPALQTALIELYAKYDDPEELEEFLKKNNNYDLEKVAKLCEK 82

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462585569  708 AKLTDQLPLIIVCdrFGFVHDLV-LYLYRNNLQRYIEIYVQKVNPSRTPAVIGGLLDVDCSE 768
Cdd:pfam00637   83 ADLYEEAVILYKK--IGNWKEAIsLLKKLGDYKDAIEYAVKSSNPELWEELLEALLDNGRFE 142
Clathrin pfam00637
Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are ...
 785-912 1.37e-24

Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are composed of multiple alpha helical repeats. They occur in the arm region of the Clathrin heavy chain.


Pssm-ID: 459884 [Multi-domain]  Cd Length: 142  Bit Score: 100.79  E-value: 1.37e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462585569  785 DELVAEVEKRNRLKLLLPWLESQIQEG-CEEPATHNALAKIYIDSN--NSPECFLRENAYYDSSVVGRYCEKRDPH-LAC 860
Cdd:pfam00637   11 SRVVKLFEKAGLLEELISYLESALKEDsRENPALQTALIELYAKYDdpEELEEFLKKNNNYDLEKVAKLCEKADLYeEAV 90

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 2462585569  861 VAYERGQCDLELIKVCNENSLFKSEARYLVCRKDPELWAHVLEETNPSRRQL 912
Cdd:pfam00637   91 ILYKKIGNWKEAISLLKKLGDYKDAIEYAVKSSNPELWEELLEALLDNGRFE 142
Clathrin pfam00637
Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are ...
 483-620 4.69e-23

Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are composed of multiple alpha helical repeats. They occur in the arm region of the Clathrin heavy chain.


Pssm-ID: 459884 [Multi-domain]  Cd Length: 142  Bit Score: 96.56  E-value: 4.69e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462585569  483 EPLANISQIVDIFMENSLIQQCTSFLLDALKNNRPAEGLLQTWLLEMNLVHAP-QVADAILgnKMFTHYDRAHIAQLCEK 561
Cdd:pfam00637    5 TDPIDVSRVVKLFEKAGLLEELISYLESALKEDSRENPALQTALIELYAKYDDpEELEEFL--KKNNNYDLEKVAKLCEK 82

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462585569  562 AGLLQQALEHYTDLYDIKRAV-VHTHLLNPEWLVNFFGSLSVEDSVECLHAMLSANIRQN 620
Cdd:pfam00637   83 ADLYEEAVILYKKIGNWKEAIsLLKKLGDYKDAIEYAVKSSNPELWEELLEALLDNGRFE 142
Clathrin_H_link pfam13838
Clathrin-H-link; This short domain is found on clathrins, and often appears on proteins ...
 298-363 9.67e-20

Clathrin-H-link; This short domain is found on clathrins, and often appears on proteins directly downstream from the Clathrin-link domain pfam09268.


Pssm-ID: 463995  Cd Length: 66  Bit Score: 84.18  E-value: 9.67e-20
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462585569  298 NLAGAEKLFVRKFNTLFAQGSYAEAAKVAASAPKGILRTRETVQKFQSIPAQSGQASPLLQYFGIL 363
Cdd:pfam13838    1 GLPGADDLYFQQFNQLLNQGDYAEAAKVAANSPRGALRTPETIQRFKQLPAQPGQLSPILQYFGTL 66
Clathrin pfam00637
Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are ...
 1216-1358 2.20e-19

Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are composed of multiple alpha helical repeats. They occur in the arm region of the Clathrin heavy chain.


Pssm-ID: 459884 [Multi-domain]  Cd Length: 142  Bit Score: 85.77  E-value: 2.20e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462585569 1216 LHIVIHADELEELMCYYQDRGYFEELILL-LEAALGLERAHMGVFTELAILYSKF-KPQKMLEHLELFWSrVNIPKVLRA 1293
Cdd:pfam00637    1 LIESTDPIDVSRVVKLFEKAGLLEELISYlESALKEDSRENPALQTALIELYAKYdDPEELEEFLKKNNN-YDLEKVAKL 79

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2462585569 1294 AEQAHLWAELVFLYDKYEEYDNAVltMMSHPTEAWKEGQfkDIITKVANVELCYRALQFYLDYKP 1358
Cdd:pfam00637   80 CEKADLYEEAVILYKKIGNWKEAI--SLLKKLGDYKDAI--EYAVKSSNPELWEELLEALLDNGR 140
Clathrin-link pfam09268
Clathrin, heavy-chain linker; Members of this family adopt a structure consisting of ...
 273-296 5.88e-08

Clathrin, heavy-chain linker; Members of this family adopt a structure consisting of alpha-alpha superhelix. They are predominantly found in clathrin, where they act as a heavy-chain linker domain.


Pssm-ID: 462732  Cd Length: 24  Bit Score: 49.75  E-value: 5.88e-08
                           10        20
                   ....*....|....*....|....
gi 2462585569  273 EDNIVNYATNVLQNPDLGLRLAVR 296
Cdd:pfam09268    1 EDNIIPYILNTLQNPDLALRLASR 24
Clathrin_propel pfam01394
Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that ...
 198-234 8.53e-06

Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that surrounds coated vesicles. The soluble assembly unit, a triskelion, contains three heavy chains and three light chains in an extended three-legged structure. Each leg contains one heavy and one light chain. The N-terminus of the heavy chain is known as the globular domain, and is composed of seven repeats which form a beta propeller.


Pssm-ID: 460192  Cd Length: 37  Bit Score: 43.94  E-value: 8.53e-06
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 2462585569  198 AAAFAEFKMEGNAKPATLFCFAVRNPTGGKLHIIEVG 234
Cdd:pfam01394    1 NAISAIIIFPTATMESWLFIIAINGTKKGQVQIVDVE 37
Coatomer_WDAD_beta-like cd22947
Coatomer WD Associated Region from Coatomer Subunit Beta and Beta'; Coatomer subunit beta', ...
 1006-1107 5.29e-05

Coatomer WD Associated Region from Coatomer Subunit Beta and Beta'; Coatomer subunit beta', also called beta'-coat protein; beta'-COP; p102, is a component of the coatomer, which is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complexes are hetero-oligomers composed of at least an alpha, beta, beta', gamma, delta, epsilon and zeta subunit. It is a heptameric complex that can polymerize into a cage to deform the membrane into a bud. This model corresponds to the WD-associated (WDAD) region found in coatomer subunits beta and beta' and is composed of a beta-propeller and an alpha-solenoid. The WD40 domain is found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly. It typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40. Between the GH and WD lies a conserved core. It forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet. Each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade. The last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure. The residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands allowing them to bind either stably or reversibly.


Pssm-ID: 438572  Cd Length: 475  Bit Score: 47.46  E-value: 5.29e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462585569 1006 LYEEAFTVF----HKFDMnasAIQvliehIGNLDRAYEFAERCNEPAVWSQLAQAQLQKDLVKEAINSYIRGDDPSSYLE 1081
Cdd:cd22947    327 LKELALEVStdpdHKFEL---ALQ-----LGDLDLALEIARESESESKWKQLGDLALSKGDFDLAEECLKKAGDLSGLLL 398

                           90       100
                   ....*....|....*....|....*.
gi 2462585569 1082 VvqsASRSNNWEDLVKFLQMARKKGR 1107
Cdd:cd22947    399 L---YSSTGDKEGLEELAELAEAAGK 421
Clathrin_propel pfam01394
Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that ...
 19-55 7.67e-04

Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that surrounds coated vesicles. The soluble assembly unit, a triskelion, contains three heavy chains and three light chains in an extended three-legged structure. Each leg contains one heavy and one light chain. The N-terminus of the heavy chain is known as the globular domain, and is composed of seven repeats which form a beta propeller.


Pssm-ID: 460192  Cd Length: 37  Bit Score: 38.17  E-value: 7.67e-04
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 2462585569   19 GINPANIGFSTLTMESDKFICIREKVGeQAQVTIIDM 55
Cdd:pfam01394    1 NAISAIIIFPTATMESWLFIIAINGTK-KGQVQIVDV 36
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 1032-1189 3.84e-03

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 40.87  E-value: 3.84e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462585569 1032 GNLDRAYEFAERC-----NEPAVWSQLAQAQLQKDLVKEAINSY-----IRGDDPSSYLEVVQSASRSNNWEDLVKFLQM 1101
Cdd:COG2956     56 GEYDRAIRIHQKLlerdpDRAEALLELAQDYLKAGLLDRAEELLeklleLDPDDAEALRLLAEIYEQEGDWEKAIEVLER 135

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462585569 1102 ARK-KGRESYIETELIFALAKTSR----VSELEDFING-PNNAHIQ-QVGDRCYEEGMYEAAKLLY--------SNVSNF 1166
Cdd:COG2956    136 LLKlGPENAHAYCELAELYLEQGDydeaIEALEKALKLdPDCARALlLLAELYLEQGDYEEAIAALeraleqdpDYLPAL 215

                          170       180
                   ....*....|....*....|...
gi 2462585569 1167 ARLASTLVHLGEYQAAVDNSRKA 1189
Cdd:COG2956    216 PRLAELYEKLGDPEEALELLRKA 238
 
Name Accession Description Interval E-value
CLH smart00299
Clathrin heavy chain repeat homology;
921-1061 9.43e-33

Clathrin heavy chain repeat homology;


Pssm-ID: 128594 [Multi-domain]  Cd Length: 140  Bit Score: 124.31  E-value: 9.43e-33
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462585569   921 LSETRDPEEISVTVKAFMTADLPNELIELLEKIVLDNSvfsEHRNLQNLLILTAIKADRTRVMEYISR-LDNYDALDIAS 999
Cdd:smart00299    1 LLEVSDPIDVSEVVELFEKRNLLEELIPYLESALKLNS---ENPALQTKLIELYAKYDPQKEIERLDNkSNHYDIEKVGK 77

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462585569  1000 IAVSSALYEEAFTVFHKFDMNASAIQVLIEHIGNLDRAYEFAERCNEPAVWSQLAQAQLQKD 1061
Cdd:smart00299   78 LCEKAKLYEEAVELYKKDGNFKDAIVTLIEHLGNYEKAIEYFVKQNNPELWAEVLKALLDKP 139
CLH smart00299
Clathrin heavy chain repeat homology;
628-766 2.09e-32

Clathrin heavy chain repeat homology;


Pssm-ID: 128594 [Multi-domain]  Cd Length: 140  Bit Score: 123.15  E-value: 2.09e-32
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462585569   628 ASKYHEQLGTQALVELFESFKSYKGLFYFLGSIVNF-SQDPDVHLKYIQAACKTGQIKEVERICRESSCYNPERVKNFLK 706
Cdd:smart00299    1 LLEVSDPIDVSEVVELFEKRNLLEELIPYLESALKLnSENPALQTKLIELYAKYDPQKEIERLDNKSNHYDIEKVGKLCE 80

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462585569   707 EAKLTDQLPLIIVCDRFgFVHDLVLYLYR-NNLQRYIEIYVQKVNPSRTPAVIGGLLDVDC 766
Cdd:smart00299   81 KAKLYEEAVELYKKDGN-FKDAIVTLIEHlGNYEKAIEYFVKQNNPELWAEVLKALLDKPR 140
Clathrin pfam00637
Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are ...
 921-1061 4.12e-30

Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are composed of multiple alpha helical repeats. They occur in the arm region of the Clathrin heavy chain.


Pssm-ID: 459884 [Multi-domain]  Cd Length: 142  Bit Score: 116.59  E-value: 4.12e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462585569  921 LSETRDPEEISVTVKAFMTADLPNELIELLEKIVLDNSvfSEHRNLQNLLILTAIKADR-TRVMEYISRLDNYDALDIAS 999
Cdd:pfam00637    1 LIESTDPIDVSRVVKLFEKAGLLEELISYLESALKEDS--RENPALQTALIELYAKYDDpEELEEFLKKNNNYDLEKVAK 78

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462585569 1000 IAVSSALYEEAFTVFHKFDMNASAIqVLIEHIGNLDRAYEFAERCNEPAVWSQLAQAQLQKD 1061
Cdd:pfam00637   79 LCEKADLYEEAVILYKKIGNWKEAI-SLLKKLGDYKDAIEYAVKSSNPELWEELLEALLDNG 139
Clathrin pfam00637
Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are ...
 1070-1209 1.94e-29

Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are composed of multiple alpha helical repeats. They occur in the arm region of the Clathrin heavy chain.


Pssm-ID: 459884 [Multi-domain]  Cd Length: 142  Bit Score: 114.66  E-value: 1.94e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462585569 1070 YIRGDDPSSYLEVVQSASRSNNWEDLVKFLQMARKKGRE--SYIETELIFALAKTSRVSELEDFINGPNNAHIQQVGDRC 1147
Cdd:pfam00637    1 LIESTDPIDVSRVVKLFEKAGLLEELISYLESALKEDSRenPALQTALIELYAKYDDPEELEEFLKKNNNYDLEKVAKLC 80

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462585569 1148 YEEGMYEAAKLLYSNVSNFARLASTLVHLGEYQAAVDNSRKASSTRTWKEVCFACMDGQEFR 1209
Cdd:pfam00637   81 EKADLYEEAVILYKKIGNWKEAISLLKKLGDYKDAIEYAVKSSNPELWEELLEALLDNGRFE 142
CLH smart00299
Clathrin heavy chain repeat homology;
1070-1207 2.44e-29

Clathrin heavy chain repeat homology;


Pssm-ID: 128594 [Multi-domain]  Cd Length: 140  Bit Score: 114.29  E-value: 2.44e-29
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462585569  1070 YIRGDDPSSYLEVVQSASRSNNWEDLVKFLQMARKKGRE-SYIETELIFALAKTSRVSELEDFINGPNNAHIQQVGDRCY 1148
Cdd:smart00299    1 LLEVSDPIDVSEVVELFEKRNLLEELIPYLESALKLNSEnPALQTKLIELYAKYDPQKEIERLDNKSNHYDIEKVGKLCE 80

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462585569  1149 EEGMYEAAKLLYSNVSNFARLASTLV-HLGEYQAAVDNSRKASSTRTWKEVCFACMDGQE 1207
Cdd:smart00299   81 KAKLYEEAVELYKKDGNFKDAIVTLIeHLGNYEKAIEYFVKQNNPELWAEVLKALLDKPR 140
CLH smart00299
Clathrin heavy chain repeat homology;
483-616 1.00e-28

Clathrin heavy chain repeat homology;


Pssm-ID: 128594 [Multi-domain]  Cd Length: 140  Bit Score: 112.75  E-value: 1.00e-28
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462585569   483 EPLANISQIVDIFMENSLIQQCTSFLLDALKNNrPAEGLLQTWLLEMNLVHAPQVADAILGNkMFTHYDRAHIAQLCEKA 562
Cdd:smart00299    5 SDPIDVSEVVELFEKRNLLEELIPYLESALKLN-SENPALQTKLIELYAKYDPQKEIERLDN-KSNHYDIEKVGKLCEKA 82

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....*..
gi 2462585569   563 GLLQQALEHYTDLYDIKRAVVHT--HLLNPEWLVNFFGS-LSVEDSVECLHAMLSAN 616
Cdd:smart00299   83 KLYEEAVELYKKDGNFKDAIVTLieHLGNYEKAIEYFVKqNNPELWAEVLKALLDKP 139
CLH smart00299
Clathrin heavy chain repeat homology;
1216-1358 1.80e-28

Clathrin heavy chain repeat homology;


Pssm-ID: 128594 [Multi-domain]  Cd Length: 140  Bit Score: 111.98  E-value: 1.80e-28
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462585569  1216 LHIVIHADELEELMCYYQDRGYFEELILLLEAALGLERAHMGVFTELAILYSKFKPQKMLEHLELFWSRVNIPKVLRAAE 1295
Cdd:smart00299    1 LLEVSDPIDVSEVVELFEKRNLLEELIPYLESALKLNSENPALQTKLIELYAKYDPQKEIERLDNKSNHYDIEKVGKLCE 80

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462585569  1296 QAHLWAELVFLYDKYEEYDNAVLTMMSHPTEAwkeGQFKDIITKVANVELCYRALQFYLDYKP 1358
Cdd:smart00299   81 KAKLYEEAVELYKKDGNFKDAIVTLIEHLGNY---EKAIEYFVKQNNPELWAEVLKALLDKPR 140
CLH smart00299
Clathrin heavy chain repeat homology;
775-902 2.90e-27

Clathrin heavy chain repeat homology;


Pssm-ID: 128594 [Multi-domain]  Cd Length: 140  Bit Score: 108.52  E-value: 2.90e-27
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462585569   775 IMAVRGQFSTDELVAEVEKRNRLKLLLPWLESQIQEGCEEPATHNALAKIYIDSNNSP--ECFLRENAYYDSSVVGRYCE 852
Cdd:smart00299    1 LLEVSDPIDVSEVVELFEKRNLLEELIPYLESALKLNSENPALQTKLIELYAKYDPQKeiERLDNKSNHYDIEKVGKLCE 80

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|..
gi 2462585569   853 KRDPH-LACVAYERGQCDLELIKVCNENS-LFKSEARYLVCRKDPELWAHVL 902
Cdd:smart00299   81 KAKLYeEAVELYKKDGNFKDAIVTLIEHLgNYEKAIEYFVKQNNPELWAEVL 132
Clathrin pfam00637
Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are ...
 630-768 4.49e-25

Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are composed of multiple alpha helical repeats. They occur in the arm region of the Clathrin heavy chain.


Pssm-ID: 459884 [Multi-domain]  Cd Length: 142  Bit Score: 102.33  E-value: 4.49e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462585569  630 KYHEQLGTQALVELFESFKSYKGLFYFLGSIVNFS--QDPDVHLKYIQAACKTGQIKEVERICRESSCYNPERVKNFLKE 707
Cdd:pfam00637    3 ESTDPIDVSRVVKLFEKAGLLEELISYLESALKEDsrENPALQTALIELYAKYDDPEELEEFLKKNNNYDLEKVAKLCEK 82

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462585569  708 AKLTDQLPLIIVCdrFGFVHDLV-LYLYRNNLQRYIEIYVQKVNPSRTPAVIGGLLDVDCSE 768
Cdd:pfam00637   83 ADLYEEAVILYKK--IGNWKEAIsLLKKLGDYKDAIEYAVKSSNPELWEELLEALLDNGRFE 142
Clathrin pfam00637
Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are ...
 785-912 1.37e-24

Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are composed of multiple alpha helical repeats. They occur in the arm region of the Clathrin heavy chain.


Pssm-ID: 459884 [Multi-domain]  Cd Length: 142  Bit Score: 100.79  E-value: 1.37e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462585569  785 DELVAEVEKRNRLKLLLPWLESQIQEG-CEEPATHNALAKIYIDSN--NSPECFLRENAYYDSSVVGRYCEKRDPH-LAC 860
Cdd:pfam00637   11 SRVVKLFEKAGLLEELISYLESALKEDsRENPALQTALIELYAKYDdpEELEEFLKKNNNYDLEKVAKLCEKADLYeEAV 90

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 2462585569  861 VAYERGQCDLELIKVCNENSLFKSEARYLVCRKDPELWAHVLEETNPSRRQL 912
Cdd:pfam00637   91 ILYKKIGNWKEAISLLKKLGDYKDAIEYAVKSSNPELWEELLEALLDNGRFE 142
Clathrin pfam00637
Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are ...
 483-620 4.69e-23

Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are composed of multiple alpha helical repeats. They occur in the arm region of the Clathrin heavy chain.


Pssm-ID: 459884 [Multi-domain]  Cd Length: 142  Bit Score: 96.56  E-value: 4.69e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462585569  483 EPLANISQIVDIFMENSLIQQCTSFLLDALKNNRPAEGLLQTWLLEMNLVHAP-QVADAILgnKMFTHYDRAHIAQLCEK 561
Cdd:pfam00637    5 TDPIDVSRVVKLFEKAGLLEELISYLESALKEDSRENPALQTALIELYAKYDDpEELEEFL--KKNNNYDLEKVAKLCEK 82

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462585569  562 AGLLQQALEHYTDLYDIKRAV-VHTHLLNPEWLVNFFGSLSVEDSVECLHAMLSANIRQN 620
Cdd:pfam00637   83 ADLYEEAVILYKKIGNWKEAIsLLKKLGDYKDAIEYAVKSSNPELWEELLEALLDNGRFE 142
Clathrin_H_link pfam13838
Clathrin-H-link; This short domain is found on clathrins, and often appears on proteins ...
 298-363 9.67e-20

Clathrin-H-link; This short domain is found on clathrins, and often appears on proteins directly downstream from the Clathrin-link domain pfam09268.


Pssm-ID: 463995  Cd Length: 66  Bit Score: 84.18  E-value: 9.67e-20
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462585569  298 NLAGAEKLFVRKFNTLFAQGSYAEAAKVAASAPKGILRTRETVQKFQSIPAQSGQASPLLQYFGIL 363
Cdd:pfam13838    1 GLPGADDLYFQQFNQLLNQGDYAEAAKVAANSPRGALRTPETIQRFKQLPAQPGQLSPILQYFGTL 66
Clathrin pfam00637
Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are ...
 1216-1358 2.20e-19

Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are composed of multiple alpha helical repeats. They occur in the arm region of the Clathrin heavy chain.


Pssm-ID: 459884 [Multi-domain]  Cd Length: 142  Bit Score: 85.77  E-value: 2.20e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462585569 1216 LHIVIHADELEELMCYYQDRGYFEELILL-LEAALGLERAHMGVFTELAILYSKF-KPQKMLEHLELFWSrVNIPKVLRA 1293
Cdd:pfam00637    1 LIESTDPIDVSRVVKLFEKAGLLEELISYlESALKEDSRENPALQTALIELYAKYdDPEELEEFLKKNNN-YDLEKVAKL 79

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2462585569 1294 AEQAHLWAELVFLYDKYEEYDNAVltMMSHPTEAWKEGQfkDIITKVANVELCYRALQFYLDYKP 1358
Cdd:pfam00637   80 CEKADLYEEAVILYKKIGNWKEAI--SLLKKLGDYKDAI--EYAVKSSNPELWEELLEALLDNGR 140
Clathrin-link pfam09268
Clathrin, heavy-chain linker; Members of this family adopt a structure consisting of ...
 273-296 5.88e-08

Clathrin, heavy-chain linker; Members of this family adopt a structure consisting of alpha-alpha superhelix. They are predominantly found in clathrin, where they act as a heavy-chain linker domain.


Pssm-ID: 462732  Cd Length: 24  Bit Score: 49.75  E-value: 5.88e-08
                           10        20
                   ....*....|....*....|....
gi 2462585569  273 EDNIVNYATNVLQNPDLGLRLAVR 296
Cdd:pfam09268    1 EDNIIPYILNTLQNPDLALRLASR 24
Clathrin_propel pfam01394
Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that ...
 198-234 8.53e-06

Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that surrounds coated vesicles. The soluble assembly unit, a triskelion, contains three heavy chains and three light chains in an extended three-legged structure. Each leg contains one heavy and one light chain. The N-terminus of the heavy chain is known as the globular domain, and is composed of seven repeats which form a beta propeller.


Pssm-ID: 460192  Cd Length: 37  Bit Score: 43.94  E-value: 8.53e-06
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 2462585569  198 AAAFAEFKMEGNAKPATLFCFAVRNPTGGKLHIIEVG 234
Cdd:pfam01394    1 NAISAIIIFPTATMESWLFIIAINGTKKGQVQIVDVE 37
Coatomer_WDAD pfam04053
Coatomer WD associated region; This region is composed of WD40 repeats.
 1015-1109 4.51e-05

Coatomer WD associated region; This region is composed of WD40 repeats.


Pssm-ID: 427679  Cd Length: 439  Bit Score: 47.61  E-value: 4.51e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462585569 1015 HKFDMnasAIQvliehIGNLDRAYEFAERCNEPAVWSQLAQAQLQKDLVKEAINSYIRGDDPS--SYLevvqsASRSNNW 1092
Cdd:pfam04053  319 TRFDL---ALE-----LGNLDVALEIAKELDDPAKWKRLGDAALSQGNIKLAEEAYQKAKDFDklLLL-----YLSTGNM 385

                           90
                   ....*....|....*..
gi 2462585569 1093 EDLVKFLQMARKKGRES 1109
Cdd:pfam04053  386 EKLKKLAKIAEKRGDYN 402
Coatomer_WDAD_beta-like cd22947
Coatomer WD Associated Region from Coatomer Subunit Beta and Beta'; Coatomer subunit beta', ...
 1006-1107 5.29e-05

Coatomer WD Associated Region from Coatomer Subunit Beta and Beta'; Coatomer subunit beta', also called beta'-coat protein; beta'-COP; p102, is a component of the coatomer, which is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complexes are hetero-oligomers composed of at least an alpha, beta, beta', gamma, delta, epsilon and zeta subunit. It is a heptameric complex that can polymerize into a cage to deform the membrane into a bud. This model corresponds to the WD-associated (WDAD) region found in coatomer subunits beta and beta' and is composed of a beta-propeller and an alpha-solenoid. The WD40 domain is found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly. It typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40. Between the GH and WD lies a conserved core. It forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet. Each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade. The last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure. The residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands allowing them to bind either stably or reversibly.


Pssm-ID: 438572  Cd Length: 475  Bit Score: 47.46  E-value: 5.29e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462585569 1006 LYEEAFTVF----HKFDMnasAIQvliehIGNLDRAYEFAERCNEPAVWSQLAQAQLQKDLVKEAINSYIRGDDPSSYLE 1081
Cdd:cd22947    327 LKELALEVStdpdHKFEL---ALQ-----LGDLDLALEIARESESESKWKQLGDLALSKGDFDLAEECLKKAGDLSGLLL 398

                           90       100
                   ....*....|....*....|....*.
gi 2462585569 1082 VvqsASRSNNWEDLVKFLQMARKKGR 1107
Cdd:cd22947    399 L---YSSTGDKEGLEELAELAEAAGK 421
Clathrin_propel pfam01394
Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that ...
 19-55 7.67e-04

Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that surrounds coated vesicles. The soluble assembly unit, a triskelion, contains three heavy chains and three light chains in an extended three-legged structure. Each leg contains one heavy and one light chain. The N-terminus of the heavy chain is known as the globular domain, and is composed of seven repeats which form a beta propeller.


Pssm-ID: 460192  Cd Length: 37  Bit Score: 38.17  E-value: 7.67e-04
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 2462585569   19 GINPANIGFSTLTMESDKFICIREKVGeQAQVTIIDM 55
Cdd:pfam01394    1 NAISAIIIFPTATMESWLFIIAINGTK-KGQVQIVDV 36
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 1032-1189 3.84e-03

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 40.87  E-value: 3.84e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462585569 1032 GNLDRAYEFAERC-----NEPAVWSQLAQAQLQKDLVKEAINSY-----IRGDDPSSYLEVVQSASRSNNWEDLVKFLQM 1101
Cdd:COG2956     56 GEYDRAIRIHQKLlerdpDRAEALLELAQDYLKAGLLDRAEELLeklleLDPDDAEALRLLAEIYEQEGDWEKAIEVLER 135

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462585569 1102 ARK-KGRESYIETELIFALAKTSR----VSELEDFING-PNNAHIQ-QVGDRCYEEGMYEAAKLLY--------SNVSNF 1166
Cdd:COG2956    136 LLKlGPENAHAYCELAELYLEQGDydeaIEALEKALKLdPDCARALlLLAELYLEQGDYEEAIAALeraleqdpDYLPAL 215

                          170       180
                   ....*....|....*....|...
gi 2462585569 1167 ARLASTLVHLGEYQAAVDNSRKA 1189
Cdd:COG2956    216 PRLAELYEKLGDPEEALELLRKA 238
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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