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GATOR1 complex protein DEPDC5 isoform X10 [Homo sapiens]
IML1 and DEP domain-containing protein( domain architecture ID 11192789)
IML1 and DEP domain-containing protein
List of domain hits
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Name | Accession | Description | Interval | E-value | |||||
IML1 | pfam12257 | Vacuolar membrane-associated protein Iml1; Proteins in this family contain a DEP domain, which ... |
101-381 | 1.09e-160 | |||||
Vacuolar membrane-associated protein Iml1; Proteins in this family contain a DEP domain, which is a globular domain of about 80 residues. This entry includes vacuolar membrane-associated protein Iml1 and DEP domain-containing protein 5/DDB_G0279099. In Saccharomyces cerevisiae, Iml1 is a subunit of both the SEA (Seh1-associated) and Iml1 complexes (Iml1-Npr2-Npr3). SEA complex is associates dynamically with the vacuole and is involved in autophagy. Iml1 complex is required for non-nitrogen-starvation (NNS)-induced autophagy. : Pssm-ID: 463510 Cd Length: 278 Bit Score: 481.62 E-value: 1.09e-160
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DEP super family | cl02442 | DEP domain, named after Dishevelled, Egl-10, and Pleckstrin, where this domain was first ... |
1179-1232 | 1.05e-18 | |||||
DEP domain, named after Dishevelled, Egl-10, and Pleckstrin, where this domain was first discovered. The function of this domain is still not clear, but it is believed to be important for the membrane association of the signaling proteins in which it is present. New studies show that the DEP domain of Sst2, a yeast RGS protein is necessary and sufficient for receptor interaction. The actual alignment was detected with superfamily member cd04449: Pssm-ID: 470580 Cd Length: 83 Bit Score: 81.94 E-value: 1.05e-18
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Name | Accession | Description | Interval | E-value | |||||
IML1 | pfam12257 | Vacuolar membrane-associated protein Iml1; Proteins in this family contain a DEP domain, which ... |
101-381 | 1.09e-160 | |||||
Vacuolar membrane-associated protein Iml1; Proteins in this family contain a DEP domain, which is a globular domain of about 80 residues. This entry includes vacuolar membrane-associated protein Iml1 and DEP domain-containing protein 5/DDB_G0279099. In Saccharomyces cerevisiae, Iml1 is a subunit of both the SEA (Seh1-associated) and Iml1 complexes (Iml1-Npr2-Npr3). SEA complex is associates dynamically with the vacuole and is involved in autophagy. Iml1 complex is required for non-nitrogen-starvation (NNS)-induced autophagy. Pssm-ID: 463510 Cd Length: 278 Bit Score: 481.62 E-value: 1.09e-160
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DEP_DEPDC5-like | cd04449 | DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in DEPDC5-like proteins. DEPDC5, in ... |
1179-1232 | 1.05e-18 | |||||
DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in DEPDC5-like proteins. DEPDC5, in human also known as KIAA0645, is a DEP domain containing protein of unknown function. Pssm-ID: 239896 Cd Length: 83 Bit Score: 81.94 E-value: 1.05e-18
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DEP | smart00049 | Domain found in Dishevelled, Egl-10, and Pleckstrin; Domain of unknown function present in ... |
1187-1232 | 3.10e-05 | |||||
Domain found in Dishevelled, Egl-10, and Pleckstrin; Domain of unknown function present in signalling proteins that contain PH, rasGEF, rhoGEF, rhoGAP, RGS, PDZ domains. DEP domain in Drosophila dishevelled is essential to rescue planar polarity defects and induce JNK signalling (Cell 94, 109-118). Pssm-ID: 214489 Cd Length: 77 Bit Score: 43.43 E-value: 3.10e-05
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DEP | pfam00610 | Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP); The DEP domain is responsible for ... |
1190-1232 | 1.60e-03 | |||||
Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP); The DEP domain is responsible for mediating intracellular protein targeting and regulation of protein stability in the cell. The DEP domain is present in a number of signaling molecules, including Regulator of G protein Signaling (RGS) proteins, and has been implicated in membrane targeting. New findings in yeast, however, demonstrate a major role for a DEP domain in mediating the interaction of an RGS protein to the C-terminal tail of a GPCR, thus placing RGS in close proximity with its substrate G protein alpha subunit. Pssm-ID: 459867 Cd Length: 71 Bit Score: 38.34 E-value: 1.60e-03
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Name | Accession | Description | Interval | E-value | |||||
IML1 | pfam12257 | Vacuolar membrane-associated protein Iml1; Proteins in this family contain a DEP domain, which ... |
101-381 | 1.09e-160 | |||||
Vacuolar membrane-associated protein Iml1; Proteins in this family contain a DEP domain, which is a globular domain of about 80 residues. This entry includes vacuolar membrane-associated protein Iml1 and DEP domain-containing protein 5/DDB_G0279099. In Saccharomyces cerevisiae, Iml1 is a subunit of both the SEA (Seh1-associated) and Iml1 complexes (Iml1-Npr2-Npr3). SEA complex is associates dynamically with the vacuole and is involved in autophagy. Iml1 complex is required for non-nitrogen-starvation (NNS)-induced autophagy. Pssm-ID: 463510 Cd Length: 278 Bit Score: 481.62 E-value: 1.09e-160
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DEP_DEPDC5-like | cd04449 | DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in DEPDC5-like proteins. DEPDC5, in ... |
1179-1232 | 1.05e-18 | |||||
DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in DEPDC5-like proteins. DEPDC5, in human also known as KIAA0645, is a DEP domain containing protein of unknown function. Pssm-ID: 239896 Cd Length: 83 Bit Score: 81.94 E-value: 1.05e-18
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DEP | cd04371 | DEP domain, named after Dishevelled, Egl-10, and Pleckstrin, where this domain was first ... |
1179-1232 | 4.36e-06 | |||||
DEP domain, named after Dishevelled, Egl-10, and Pleckstrin, where this domain was first discovered. The function of this domain is still not clear, but it is believed to be important for the membrane association of the signaling proteins in which it is present. New studies show that the DEP domain of Sst2, a yeast RGS protein is necessary and sufficient for receptor interaction. Pssm-ID: 239836 Cd Length: 81 Bit Score: 45.79 E-value: 4.36e-06
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DEP | smart00049 | Domain found in Dishevelled, Egl-10, and Pleckstrin; Domain of unknown function present in ... |
1187-1232 | 3.10e-05 | |||||
Domain found in Dishevelled, Egl-10, and Pleckstrin; Domain of unknown function present in signalling proteins that contain PH, rasGEF, rhoGEF, rhoGAP, RGS, PDZ domains. DEP domain in Drosophila dishevelled is essential to rescue planar polarity defects and induce JNK signalling (Cell 94, 109-118). Pssm-ID: 214489 Cd Length: 77 Bit Score: 43.43 E-value: 3.10e-05
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DEP | pfam00610 | Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP); The DEP domain is responsible for ... |
1190-1232 | 1.60e-03 | |||||
Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP); The DEP domain is responsible for mediating intracellular protein targeting and regulation of protein stability in the cell. The DEP domain is present in a number of signaling molecules, including Regulator of G protein Signaling (RGS) proteins, and has been implicated in membrane targeting. New findings in yeast, however, demonstrate a major role for a DEP domain in mediating the interaction of an RGS protein to the C-terminal tail of a GPCR, thus placing RGS in close proximity with its substrate G protein alpha subunit. Pssm-ID: 459867 Cd Length: 71 Bit Score: 38.34 E-value: 1.60e-03
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