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Conserved domains on  [gi|2462489227|ref|XP_054185450|]
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pyruvate kinase PKLR isoform X2 [Homo sapiens]

Protein Classification

pyruvate kinase( domain architecture ID 10084586)

pyruvate kinase catalyzes the phosphorylation of pyruvate to form phosphoenolpyruvate and functions in regulating glycolysis

CATH:  2.40.33.10|3.20.20.60|3.40.1380.20
EC:  2.7.1.40
Gene Ontology:  GO:0004743|GO:0006096|GO:0005524|GO:0030955|GO:0000287
PubMed:  31342570
SCOP:  4003255|4002474|4000500

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Pyruvate_Kinase cd00288
Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of ...
 21-509 0e+00

Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low affinity T state. PK exists as several different isozymes, depending on organism and tissue type. In mammals, there are four PK isozymes: R, found in red blood cells, L, found in liver, M1, found in skeletal muscle, and M2, found in kidney, adipose tissue, and lung. PK forms a homotetramer, with each subunit containing three domains. The T state to R state transition of PK is more complex than in most allosteric enzymes, involving a concerted rotation of all 3 domains of each monomer in the homotetramer.


:

Pssm-ID: 238178 [Multi-domain]  Cd Length: 480  Bit Score: 811.16  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462489227  21 ARSTSIIATIGPASRSVERLKEMIKAGMNIARLNFSHGSHEYHAESIANVREAVESFAGsplsyrPVAIALDTKGPEIRT 100
Cdd:cd00288     1 LRRTKIVCTIGPATDSVENLKKLIKAGMNVARMNFSHGSHEYHQSRIDNVREAAEKTGG------PVAIALDTKGPEIRT 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462489227 101 GILQGGpeSEVELVKGSQVLVTVDPAfRTRGNANTVWVDYPNIVRVVPVGGRIYIDDGLISLVVQKIGPE-GLVTQVENG 179
Cdd:cd00288    75 GLFKGG--KDISLKAGDKFLVTTDPA-AKKGTKEKIYVDYKNLTKDVSPGNTILVDDGLLSLKVLSKDDDkTLVCEVLNG 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462489227 180 GVLGSRKGVNLPGAQVDLPGLSEQDVRDLRFGVEHGVDIVFASFVRKASDVAAVRAALGPEGHGIKIISKIENHEGVKRF 259
Cdd:cd00288   152 GVLGSRKGVNLPGTDVDLPALSEKDKADLRFGVEQGVDMIFASFVRKASDVLEIREVLGEKGKDIKIIAKIENQEGVNNF 231

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462489227 260 DEILEVSDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNLAGKPVVCATQMLESMITKPRPTRAETSDVANAVLDGADCIM 339
Cdd:cd00288   232 DEILEASDGIMVARGDLGVEIPAEEVFLAQKMLIAKCNLAGKPVITATQMLESMIYNPRPTRAEVSDVANAVLDGTDCVM 311

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462489227 340 LSGETAKGNFPVEAVKMQHAIAREAEAAVYHRQLFEELRRAAPLSRDPTEVTAIGAVEAAFKCCAAAIIVLTTTGRSAQL 419
Cdd:cd00288   312 LSGETAKGKYPVEAVKAMARICLEAEKALSHRVLFNEMRRLTPRPTSTTEAVAMSAVRAAFELGAKAIVVLTTSGRTARL 391

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462489227 420 LSRYRPRAAVIAVTRSAQAARQVHLCRGVFPLLYREPPEaIWADDVDRRVQFGIESGKLRGFLRVGDLVIVVTGWRPGSG 499
Cdd:cd00288   392 VSKYRPNAPIIAVTRNEQTARQLHLYRGVYPVLFEEPKP-GWQEDTDARLKAAVNVAKEKGLLKKGDLVVVVQGWPVGSG 470

                         490
                  ....*....|
gi 2462489227 500 YTNIMRVLSI 509
Cdd:cd00288   471 STNTMRILTV 480
 
Name Accession Description Interval E-value
Pyruvate_Kinase cd00288
Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of ...
 21-509 0e+00

Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low affinity T state. PK exists as several different isozymes, depending on organism and tissue type. In mammals, there are four PK isozymes: R, found in red blood cells, L, found in liver, M1, found in skeletal muscle, and M2, found in kidney, adipose tissue, and lung. PK forms a homotetramer, with each subunit containing three domains. The T state to R state transition of PK is more complex than in most allosteric enzymes, involving a concerted rotation of all 3 domains of each monomer in the homotetramer.


Pssm-ID: 238178 [Multi-domain]  Cd Length: 480  Bit Score: 811.16  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462489227  21 ARSTSIIATIGPASRSVERLKEMIKAGMNIARLNFSHGSHEYHAESIANVREAVESFAGsplsyrPVAIALDTKGPEIRT 100
Cdd:cd00288     1 LRRTKIVCTIGPATDSVENLKKLIKAGMNVARMNFSHGSHEYHQSRIDNVREAAEKTGG------PVAIALDTKGPEIRT 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462489227 101 GILQGGpeSEVELVKGSQVLVTVDPAfRTRGNANTVWVDYPNIVRVVPVGGRIYIDDGLISLVVQKIGPE-GLVTQVENG 179
Cdd:cd00288    75 GLFKGG--KDISLKAGDKFLVTTDPA-AKKGTKEKIYVDYKNLTKDVSPGNTILVDDGLLSLKVLSKDDDkTLVCEVLNG 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462489227 180 GVLGSRKGVNLPGAQVDLPGLSEQDVRDLRFGVEHGVDIVFASFVRKASDVAAVRAALGPEGHGIKIISKIENHEGVKRF 259
Cdd:cd00288   152 GVLGSRKGVNLPGTDVDLPALSEKDKADLRFGVEQGVDMIFASFVRKASDVLEIREVLGEKGKDIKIIAKIENQEGVNNF 231

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462489227 260 DEILEVSDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNLAGKPVVCATQMLESMITKPRPTRAETSDVANAVLDGADCIM 339
Cdd:cd00288   232 DEILEASDGIMVARGDLGVEIPAEEVFLAQKMLIAKCNLAGKPVITATQMLESMIYNPRPTRAEVSDVANAVLDGTDCVM 311

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462489227 340 LSGETAKGNFPVEAVKMQHAIAREAEAAVYHRQLFEELRRAAPLSRDPTEVTAIGAVEAAFKCCAAAIIVLTTTGRSAQL 419
Cdd:cd00288   312 LSGETAKGKYPVEAVKAMARICLEAEKALSHRVLFNEMRRLTPRPTSTTEAVAMSAVRAAFELGAKAIVVLTTSGRTARL 391

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462489227 420 LSRYRPRAAVIAVTRSAQAARQVHLCRGVFPLLYREPPEaIWADDVDRRVQFGIESGKLRGFLRVGDLVIVVTGWRPGSG 499
Cdd:cd00288   392 VSKYRPNAPIIAVTRNEQTARQLHLYRGVYPVLFEEPKP-GWQEDTDARLKAAVNVAKEKGLLKKGDLVVVVQGWPVGSG 470

                         490
                  ....*....|
gi 2462489227 500 YTNIMRVLSI 509
Cdd:cd00288   471 STNTMRILTV 480
pyruv_kin TIGR01064
pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of ...
 22-506 0e+00

pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of fructose-1,6-bisphosphate or similar phosphorylated sugars. [Energy metabolism, Glycolysis/gluconeogenesis]


Pssm-ID: 273424 [Multi-domain]  Cd Length: 472  Bit Score: 676.69  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462489227  22 RSTSIIATIGPASRSVERLKEMIKAGMNIARLNFSHGSHEYHAESIANVREAVESFAgsplsyRPVAIALDTKGPEIRTG 101
Cdd:TIGR01064   1 RRTKIVCTIGPATNSPEMLKKLLDAGMNVARLNFSHGSHEEHGKRIENVREAAEKLG------RPVAILLDTKGPEIRTG 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462489227 102 ILQGGPeseVELVKGSQVLVTVDPAFRTrGNANTVWVDYPNIVRVVPVGGRIYIDDGLISLVVQKIGPEGLVTQVENGGV 181
Cdd:TIGR01064  75 EIKGGE---VKLKKGDKVIITTDDIKGE-GDEEKVYVDYKGLTKDVVEGDKILVDDGKISLVVVSVEGDKVICEVLNGGT 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462489227 182 LGSRKGVNLPGAQVDLPGLSEQDVRDLRFGVEHGVDIVFASFVRKASDVAAVRAALGPEGHG-IKIISKIENHEGVKRFD 260
Cdd:TIGR01064 151 LKSKKGVNLPGADVDLPALSEKDKKDLKFGVEQGVDMVAASFVRTAEDVLEVREVLGEKGAKdVKIIAKIENQEGVDNID 230

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462489227 261 EILEVSDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNLAGKPVVCATQMLESMITKPRPTRAETSDVANAVLDGADCIML 340
Cdd:TIGR01064 231 EIAEASDGIMVARGDLGVEIPAEEVPIAQKKMIRKCNRAGKPVITATQMLDSMIKNPRPTRAEVSDVANAVLDGTDAVML 310

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462489227 341 SGETAKGNFPVEAVKMQHAIAREAEAAVYHRQLFEELRRAAPLSRDPTEVTAIGAVEAAFKCCAAAIIVLTTTGRSAQLL 420
Cdd:TIGR01064 311 SGETAKGKYPVEAVQMMAKIAKEAEKALAYLTNFNDRKNSDPKPSTITEAIALSAVEAAEKLDAKAIVVLTESGRTARLL 390

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462489227 421 SRYRPRAAVIAVTRSAQAARQVHLCRGVFPLLYREppeaiWADDVDRRVQFGIESGKLRGFLRVGDLVIVVTG-WRPGSG 499
Cdd:TIGR01064 391 SKYRPNAPIIAVTPNERVARQLALYWGVFPFLVDE-----EPSDTDARVNKALELLKEKGIVKKGDLVVVIQGgPIGGEG 465


                  ....*..
gi 2462489227 500 YTNIMRV 506
Cdd:TIGR01064 466 GTNTIRV 472
PykF COG0469
Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the ...
 22-509 0e+00

Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the Pathway/BioSystem: Glycolysis


Pssm-ID: 440237 [Multi-domain]  Cd Length: 471  Bit Score: 638.23  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462489227  22 RSTSIIATIGPASRSVERLKEMIKAGMNIARLNFSHGSHEYHAESIANVREAVESFAgsplsyRPVAIALDTKGPEIRTG 101
Cdd:COG0469     3 RRTKIVATLGPASDSPEVLRKLIEAGMDVARLNFSHGDHEEHRERIELIREAAKELG------RPVAILLDLQGPKIRTG 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462489227 102 ILQGGPeseVELVKGSQVLVTVDPafrTRGNANTVWVDYPNIVRVVPVGGRIYIDDGLISLVVQKIGPEGLVTQVENGGV 181
Cdd:COG0469    77 KFKEGP---VELKKGDTFTLTTDD---VEGDAERVSVTYPELPEDVKPGDRILLDDGKIELRVEEVEGDEVVCEVVNGGV 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462489227 182 LGSRKGVNLPGAQVDLPGLSEQDVRDLRFGVEHGVDIVFASFVRKASDVAAVRAALGPEGHGIKIISKIENHEGVKRFDE 261
Cdd:COG0469   151 LSSRKGVNLPGVGLSLPALTEKDREDLKFALELGVDFIALSFVRSAEDVLEARELLEEAGGRAPIIAKIEKPEAVENLDE 230

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462489227 262 ILEVSDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNLAGKPVVCATQMLESMITKPRPTRAETSDVANAVLDGADCIMLS 341
Cdd:COG0469   231 IIEASDGIMVARGDLGVEIPLEEVPLIQKRIIRKARRAGKPVITATQMLESMIENPRPTRAEVSDVANAVLDGTDAVMLS 310

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462489227 342 GETAKGNFPVEAVKMQHAIAREAEAAVYHRQLFEELRRAAPlsRDPTEVTAIGAVEAAFKCCAAAIIVLTTTGRSAQLLS 421
Cdd:COG0469   311 GETAVGKYPVEAVETMARIAEEAEKSLDYRRILDRLRDEPE--RTITDAIARAAVELAEDLGAKAIVAFTESGSTARRIS 388

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462489227 422 RYRPRAAVIAVTRSAQAARQVHLCRGVFPLLYREppeaiwADDVDRRVQFGIESGKLRGFLRVGDLVIVVTGWRPG-SGY 500
Cdd:COG0469   389 RYRPKVPILALTPNERTARRLALVWGVYPVLVDD------VESTDEMIEEAVEALLEEGLVKPGDLVVITAGVPVGvPGT 462


                  ....*....
gi 2462489227 501 TNIMRVLSI 509
Cdd:COG0469   463 TNTLKVHRV 471
PK pfam00224
Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain ...
 21-374 0e+00

Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain nested within a larger TIM barrel. The active site is found in a cleft between the two domains.


Pssm-ID: 395168 [Multi-domain]  Cd Length: 348  Bit Score: 619.00  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462489227  21 ARSTSIIATIGPASRSVERLKEMIKAGMNIARLNFSHGSHEYHAESIANVREAVESFAGSplsyrpVAIALDTKGPEIRT 100
Cdd:pfam00224   1 LRRTKIVCTIGPASNSVENLEKLIEAGANVARMNFSHGSHEYHQSRIDNVREAEEKTGGT------VAIALDTKGPEIRT 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462489227 101 GILQGGPeSEVELVKGSQVLVTVDPAFRTRGNANTVWVDYPNIVRVVPVGGRIYIDDGLISLVVQKIGPE-GLVTQVENG 179
Cdd:pfam00224  75 GNTKDGK-KDIELKAGDEMIVSTDAKYKGACDDEMIYVDYKNIVKDVSVGGTILVDDGLLSLKVLSKDDDkTLVVEVLNG 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462489227 180 GVLGSRKGVNLPGAQVDLPGLSEQDVRDLRFGVEHGVDIVFASFVRKASDVAAVRAALGPEGHGIKIISKIENHEGVKRF 259
Cdd:pfam00224 154 GVIGSRKGVNLPGTDVDLPALSEKDKADLRFGVKNGVDMIFASFVRKASDVLEIREVLGEAGKNIQIIAKIENQEGVNNF 233

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462489227 260 DEILEVSDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNLAGKPVVCATQMLESMITKPRPTRAETSDVANAVLDGADCIM 339
Cdd:pfam00224 234 DEILEATDGIMVARGDLGIEIPAEEVFLAQKMLIAKCNLAGKPVITATQMLESMIYNPRPTRAEVSDVANAVLDGTDCVM 313

                         330       340       350
                  ....*....|....*....|....*....|....*
gi 2462489227 340 LSGETAKGNFPVEAVKMQHAIAREAEAAVYHRQLF 374
Cdd:pfam00224 314 LSGETAKGNYPVEAVRMMHEICLEAEKALPHRNLF 348
PRK05826 PRK05826
pyruvate kinase; Provisional
 22-493 0e+00

pyruvate kinase; Provisional


Pssm-ID: 235619 [Multi-domain]  Cd Length: 465  Bit Score: 538.20  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462489227  22 RSTSIIATIGPASRSVERLKEMIKAGMNIARLNFSHGSHEYHAESIANVREAVESfAGsplsyRPVAIALDTKGPEIRTG 101
Cdd:PRK05826    4 RRTKIVATLGPASDSPENLEKLIEAGVNVVRLNFSHGSHEEHGKRAALVREIAAK-LG-----RPVAILLDLKGPKIRVG 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462489227 102 ILQGGPeseVELVKGSQVLVTVDPAFRtrGNANTVWVDYPNIVRVVPVGGRIYIDDGLISLVVQKIGPEGLVTQVENGGV 181
Cdd:PRK05826   78 KFKEGK---ITLKTGDKFTLDTDQKEE--GDKERVGVDYKGLPKDVKPGDILLLDDGKLQLKVVEVDGDEVETEVKNGGP 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462489227 182 LGSRKGVNLPGAQVDLPGLSEQDVRDLRFGVEHGVDIVFASFVRKASDVAAVRAAL---GpeGHGIKIISKIENHEGVKR 258
Cdd:PRK05826  153 LSNNKGINIPGGGLSLPALTEKDKADIKFAAEQGVDYIAVSFVRSAEDVEEARRLLreaG--CPHAKIIAKIERAEAVDN 230

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462489227 259 FDEILEVSDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNLAGKPVVCATQMLESMITKPRPTRAETSDVANAVLDGADCI 338
Cdd:PRK05826  231 IDEIIEASDGIMVARGDLGVEIPDEEVPGLQKKIIRKAREAGKPVITATQMLESMIENPRPTRAEVSDVANAVLDGTDAV 310

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462489227 339 MLSGETAKGNFPVEAVKMQHAIAREAEAAVYHRQLFEELRRAaplSRDPTEVTAIGAVEAAFK-CCAAAIIVLTTTGRSA 417
Cdd:PRK05826  311 MLSGETAAGKYPVEAVEAMARICKGAEKEFSINLSKHRLDRQ---FDRIDEAIAMSAMYAANHlKGVKAIVALTESGRTA 387

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462489227 418 QLLSRYRPRAAVIAVTRSAQAARQVHLCRGVFPLLYREPPEAIWADDVDrrvqfgIESGKLRGFLRVGDLVIVVTG 493
Cdd:PRK05826  388 RLISRFRPGAPIFAVTRDEKTQRRLALYRGVYPVLFDSAADTDDAAEEA------LRLLLEKGLVESGDLVVVTSG 457
 
Name Accession Description Interval E-value
Pyruvate_Kinase cd00288
Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of ...
 21-509 0e+00

Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low affinity T state. PK exists as several different isozymes, depending on organism and tissue type. In mammals, there are four PK isozymes: R, found in red blood cells, L, found in liver, M1, found in skeletal muscle, and M2, found in kidney, adipose tissue, and lung. PK forms a homotetramer, with each subunit containing three domains. The T state to R state transition of PK is more complex than in most allosteric enzymes, involving a concerted rotation of all 3 domains of each monomer in the homotetramer.


Pssm-ID: 238178 [Multi-domain]  Cd Length: 480  Bit Score: 811.16  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462489227  21 ARSTSIIATIGPASRSVERLKEMIKAGMNIARLNFSHGSHEYHAESIANVREAVESFAGsplsyrPVAIALDTKGPEIRT 100
Cdd:cd00288     1 LRRTKIVCTIGPATDSVENLKKLIKAGMNVARMNFSHGSHEYHQSRIDNVREAAEKTGG------PVAIALDTKGPEIRT 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462489227 101 GILQGGpeSEVELVKGSQVLVTVDPAfRTRGNANTVWVDYPNIVRVVPVGGRIYIDDGLISLVVQKIGPE-GLVTQVENG 179
Cdd:cd00288    75 GLFKGG--KDISLKAGDKFLVTTDPA-AKKGTKEKIYVDYKNLTKDVSPGNTILVDDGLLSLKVLSKDDDkTLVCEVLNG 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462489227 180 GVLGSRKGVNLPGAQVDLPGLSEQDVRDLRFGVEHGVDIVFASFVRKASDVAAVRAALGPEGHGIKIISKIENHEGVKRF 259
Cdd:cd00288   152 GVLGSRKGVNLPGTDVDLPALSEKDKADLRFGVEQGVDMIFASFVRKASDVLEIREVLGEKGKDIKIIAKIENQEGVNNF 231

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462489227 260 DEILEVSDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNLAGKPVVCATQMLESMITKPRPTRAETSDVANAVLDGADCIM 339
Cdd:cd00288   232 DEILEASDGIMVARGDLGVEIPAEEVFLAQKMLIAKCNLAGKPVITATQMLESMIYNPRPTRAEVSDVANAVLDGTDCVM 311

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462489227 340 LSGETAKGNFPVEAVKMQHAIAREAEAAVYHRQLFEELRRAAPLSRDPTEVTAIGAVEAAFKCCAAAIIVLTTTGRSAQL 419
Cdd:cd00288   312 LSGETAKGKYPVEAVKAMARICLEAEKALSHRVLFNEMRRLTPRPTSTTEAVAMSAVRAAFELGAKAIVVLTTSGRTARL 391

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462489227 420 LSRYRPRAAVIAVTRSAQAARQVHLCRGVFPLLYREPPEaIWADDVDRRVQFGIESGKLRGFLRVGDLVIVVTGWRPGSG 499
Cdd:cd00288   392 VSKYRPNAPIIAVTRNEQTARQLHLYRGVYPVLFEEPKP-GWQEDTDARLKAAVNVAKEKGLLKKGDLVVVVQGWPVGSG 470

                         490
                  ....*....|
gi 2462489227 500 YTNIMRVLSI 509
Cdd:cd00288   471 STNTMRILTV 480
pyruv_kin TIGR01064
pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of ...
 22-506 0e+00

pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of fructose-1,6-bisphosphate or similar phosphorylated sugars. [Energy metabolism, Glycolysis/gluconeogenesis]


Pssm-ID: 273424 [Multi-domain]  Cd Length: 472  Bit Score: 676.69  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462489227  22 RSTSIIATIGPASRSVERLKEMIKAGMNIARLNFSHGSHEYHAESIANVREAVESFAgsplsyRPVAIALDTKGPEIRTG 101
Cdd:TIGR01064   1 RRTKIVCTIGPATNSPEMLKKLLDAGMNVARLNFSHGSHEEHGKRIENVREAAEKLG------RPVAILLDTKGPEIRTG 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462489227 102 ILQGGPeseVELVKGSQVLVTVDPAFRTrGNANTVWVDYPNIVRVVPVGGRIYIDDGLISLVVQKIGPEGLVTQVENGGV 181
Cdd:TIGR01064  75 EIKGGE---VKLKKGDKVIITTDDIKGE-GDEEKVYVDYKGLTKDVVEGDKILVDDGKISLVVVSVEGDKVICEVLNGGT 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462489227 182 LGSRKGVNLPGAQVDLPGLSEQDVRDLRFGVEHGVDIVFASFVRKASDVAAVRAALGPEGHG-IKIISKIENHEGVKRFD 260
Cdd:TIGR01064 151 LKSKKGVNLPGADVDLPALSEKDKKDLKFGVEQGVDMVAASFVRTAEDVLEVREVLGEKGAKdVKIIAKIENQEGVDNID 230

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462489227 261 EILEVSDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNLAGKPVVCATQMLESMITKPRPTRAETSDVANAVLDGADCIML 340
Cdd:TIGR01064 231 EIAEASDGIMVARGDLGVEIPAEEVPIAQKKMIRKCNRAGKPVITATQMLDSMIKNPRPTRAEVSDVANAVLDGTDAVML 310

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462489227 341 SGETAKGNFPVEAVKMQHAIAREAEAAVYHRQLFEELRRAAPLSRDPTEVTAIGAVEAAFKCCAAAIIVLTTTGRSAQLL 420
Cdd:TIGR01064 311 SGETAKGKYPVEAVQMMAKIAKEAEKALAYLTNFNDRKNSDPKPSTITEAIALSAVEAAEKLDAKAIVVLTESGRTARLL 390

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462489227 421 SRYRPRAAVIAVTRSAQAARQVHLCRGVFPLLYREppeaiWADDVDRRVQFGIESGKLRGFLRVGDLVIVVTG-WRPGSG 499
Cdd:TIGR01064 391 SKYRPNAPIIAVTPNERVARQLALYWGVFPFLVDE-----EPSDTDARVNKALELLKEKGIVKKGDLVVVIQGgPIGGEG 465


                  ....*..
gi 2462489227 500 YTNIMRV 506
Cdd:TIGR01064 466 GTNTIRV 472
PykF COG0469
Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the ...
 22-509 0e+00

Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the Pathway/BioSystem: Glycolysis


Pssm-ID: 440237 [Multi-domain]  Cd Length: 471  Bit Score: 638.23  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462489227  22 RSTSIIATIGPASRSVERLKEMIKAGMNIARLNFSHGSHEYHAESIANVREAVESFAgsplsyRPVAIALDTKGPEIRTG 101
Cdd:COG0469     3 RRTKIVATLGPASDSPEVLRKLIEAGMDVARLNFSHGDHEEHRERIELIREAAKELG------RPVAILLDLQGPKIRTG 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462489227 102 ILQGGPeseVELVKGSQVLVTVDPafrTRGNANTVWVDYPNIVRVVPVGGRIYIDDGLISLVVQKIGPEGLVTQVENGGV 181
Cdd:COG0469    77 KFKEGP---VELKKGDTFTLTTDD---VEGDAERVSVTYPELPEDVKPGDRILLDDGKIELRVEEVEGDEVVCEVVNGGV 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462489227 182 LGSRKGVNLPGAQVDLPGLSEQDVRDLRFGVEHGVDIVFASFVRKASDVAAVRAALGPEGHGIKIISKIENHEGVKRFDE 261
Cdd:COG0469   151 LSSRKGVNLPGVGLSLPALTEKDREDLKFALELGVDFIALSFVRSAEDVLEARELLEEAGGRAPIIAKIEKPEAVENLDE 230

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462489227 262 ILEVSDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNLAGKPVVCATQMLESMITKPRPTRAETSDVANAVLDGADCIMLS 341
Cdd:COG0469   231 IIEASDGIMVARGDLGVEIPLEEVPLIQKRIIRKARRAGKPVITATQMLESMIENPRPTRAEVSDVANAVLDGTDAVMLS 310

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462489227 342 GETAKGNFPVEAVKMQHAIAREAEAAVYHRQLFEELRRAAPlsRDPTEVTAIGAVEAAFKCCAAAIIVLTTTGRSAQLLS 421
Cdd:COG0469   311 GETAVGKYPVEAVETMARIAEEAEKSLDYRRILDRLRDEPE--RTITDAIARAAVELAEDLGAKAIVAFTESGSTARRIS 388

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462489227 422 RYRPRAAVIAVTRSAQAARQVHLCRGVFPLLYREppeaiwADDVDRRVQFGIESGKLRGFLRVGDLVIVVTGWRPG-SGY 500
Cdd:COG0469   389 RYRPKVPILALTPNERTARRLALVWGVYPVLVDD------VESTDEMIEEAVEALLEEGLVKPGDLVVITAGVPVGvPGT 462


                  ....*....
gi 2462489227 501 TNIMRVLSI 509
Cdd:COG0469   463 TNTLKVHRV 471
PK pfam00224
Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain ...
 21-374 0e+00

Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain nested within a larger TIM barrel. The active site is found in a cleft between the two domains.


Pssm-ID: 395168 [Multi-domain]  Cd Length: 348  Bit Score: 619.00  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462489227  21 ARSTSIIATIGPASRSVERLKEMIKAGMNIARLNFSHGSHEYHAESIANVREAVESFAGSplsyrpVAIALDTKGPEIRT 100
Cdd:pfam00224   1 LRRTKIVCTIGPASNSVENLEKLIEAGANVARMNFSHGSHEYHQSRIDNVREAEEKTGGT------VAIALDTKGPEIRT 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462489227 101 GILQGGPeSEVELVKGSQVLVTVDPAFRTRGNANTVWVDYPNIVRVVPVGGRIYIDDGLISLVVQKIGPE-GLVTQVENG 179
Cdd:pfam00224  75 GNTKDGK-KDIELKAGDEMIVSTDAKYKGACDDEMIYVDYKNIVKDVSVGGTILVDDGLLSLKVLSKDDDkTLVVEVLNG 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462489227 180 GVLGSRKGVNLPGAQVDLPGLSEQDVRDLRFGVEHGVDIVFASFVRKASDVAAVRAALGPEGHGIKIISKIENHEGVKRF 259
Cdd:pfam00224 154 GVIGSRKGVNLPGTDVDLPALSEKDKADLRFGVKNGVDMIFASFVRKASDVLEIREVLGEAGKNIQIIAKIENQEGVNNF 233

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462489227 260 DEILEVSDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNLAGKPVVCATQMLESMITKPRPTRAETSDVANAVLDGADCIM 339
Cdd:pfam00224 234 DEILEATDGIMVARGDLGIEIPAEEVFLAQKMLIAKCNLAGKPVITATQMLESMIYNPRPTRAEVSDVANAVLDGTDCVM 313

                         330       340       350
                  ....*....|....*....|....*....|....*
gi 2462489227 340 LSGETAKGNFPVEAVKMQHAIAREAEAAVYHRQLF 374
Cdd:pfam00224 314 LSGETAKGNYPVEAVRMMHEICLEAEKALPHRNLF 348
PRK05826 PRK05826
pyruvate kinase; Provisional
 22-493 0e+00

pyruvate kinase; Provisional


Pssm-ID: 235619 [Multi-domain]  Cd Length: 465  Bit Score: 538.20  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462489227  22 RSTSIIATIGPASRSVERLKEMIKAGMNIARLNFSHGSHEYHAESIANVREAVESfAGsplsyRPVAIALDTKGPEIRTG 101
Cdd:PRK05826    4 RRTKIVATLGPASDSPENLEKLIEAGVNVVRLNFSHGSHEEHGKRAALVREIAAK-LG-----RPVAILLDLKGPKIRVG 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462489227 102 ILQGGPeseVELVKGSQVLVTVDPAFRtrGNANTVWVDYPNIVRVVPVGGRIYIDDGLISLVVQKIGPEGLVTQVENGGV 181
Cdd:PRK05826   78 KFKEGK---ITLKTGDKFTLDTDQKEE--GDKERVGVDYKGLPKDVKPGDILLLDDGKLQLKVVEVDGDEVETEVKNGGP 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462489227 182 LGSRKGVNLPGAQVDLPGLSEQDVRDLRFGVEHGVDIVFASFVRKASDVAAVRAAL---GpeGHGIKIISKIENHEGVKR 258
Cdd:PRK05826  153 LSNNKGINIPGGGLSLPALTEKDKADIKFAAEQGVDYIAVSFVRSAEDVEEARRLLreaG--CPHAKIIAKIERAEAVDN 230

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462489227 259 FDEILEVSDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNLAGKPVVCATQMLESMITKPRPTRAETSDVANAVLDGADCI 338
Cdd:PRK05826  231 IDEIIEASDGIMVARGDLGVEIPDEEVPGLQKKIIRKAREAGKPVITATQMLESMIENPRPTRAEVSDVANAVLDGTDAV 310

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462489227 339 MLSGETAKGNFPVEAVKMQHAIAREAEAAVYHRQLFEELRRAaplSRDPTEVTAIGAVEAAFK-CCAAAIIVLTTTGRSA 417
Cdd:PRK05826  311 MLSGETAAGKYPVEAVEAMARICKGAEKEFSINLSKHRLDRQ---FDRIDEAIAMSAMYAANHlKGVKAIVALTESGRTA 387

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462489227 418 QLLSRYRPRAAVIAVTRSAQAARQVHLCRGVFPLLYREPPEAIWADDVDrrvqfgIESGKLRGFLRVGDLVIVVTG 493
Cdd:PRK05826  388 RLISRFRPGAPIFAVTRDEKTQRRLALYRGVYPVLFDSAADTDDAAEEA------LRLLLEKGLVESGDLVVVTSG 457
PLN02461 PLN02461
Probable pyruvate kinase
 24-491 0e+00

Probable pyruvate kinase


Pssm-ID: 215255 [Multi-domain]  Cd Length: 511  Bit Score: 530.32  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462489227  24 TSIIATIGPASRSVERLKEMIKAGMNIARLNFSHGSHEYHAESIANVREAVESfagsplSYRPVAIALDTKGPEIRTGIL 103
Cdd:PLN02461   23 TKIVCTLGPASRSVPMLEKLLRAGMNVARFNFSHGSHEYHQETLDNLRQAMAN------TGILCAVMLDTKGPEIRTGFL 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462489227 104 Q-GGPeseVELVKGSQVLVTVDpaFRTRGNANTVWVDYPNIVRVVPVGGRIYIDDGLISLVVQKIGPE-GLVT-QVENGG 180
Cdd:PLN02461   97 KdGKP---VQLKQGQEITITTD--YSIKGDENMIAMSYKKLAVDVKPGSVILCADGTITLTVLSCDVEaGTVRcRCENSA 171

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462489227 181 VLGSRKGVNLPGAQVDLPGLSEQDVRD-LRFGVEHGVDIVFASFVRKASDVAAVRAALGPEGHGIKIISKIENHEGVKRF 259
Cdd:PLN02461  172 MLGERKNVNLPGVVVDLPTLTEKDKEDiLQWGVPNKIDFIALSFVRKGSDLVEVRKVLGEHAKSILLISKVENQEGLDNF 251

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462489227 260 DEILEVSDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNLAGKPVVCATQMLESMITKPRPTRAETSDVANAVLDGADCIM 339
Cdd:PLN02461  252 DDILAESDAFMVARGDLGMEIPIEKIFLAQKMMIYKCNLAGKPVVTATQMLESMIKSPRPTRAEATDVANAVLDGTDCVM 331

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462489227 340 LSGETAKGNFPVEAVKMQHAIAREAEAAVYHRQLFEELRRAAPLSRDPTEVTAIGAVEAAFKCCAAAIIVLTTTGRSAQL 419
Cdd:PLN02461  332 LSGETAAGAYPELAVKTMARICREAEASLDYGALFKEIMRSAPLPMSPLESLASSAVRTANKVKASLIVVLTRGGTTARL 411

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462489227 420 LSRYRPRAAVIAV------TRSAQ-------AARQVHLCRGVFPLLYREPPEAIWADDVDRRVQFGIESGKLRGFLRVGD 486
Cdd:PLN02461  412 VAKYRPAVPILSVvvpeitTDSFDwscsdeaPARHSLIYRGLIPVLAEGSAKATDSESTEEILEAAIEHAKKKGLCKPGD 491


                  ....*
gi 2462489227 487 LVIVV 491
Cdd:PLN02461  492 SVVAL 496
PRK09206 PRK09206
pyruvate kinase PykF;
22-506 6.22e-178

pyruvate kinase PykF;


Pssm-ID: 181699 [Multi-domain]  Cd Length: 470  Bit Score: 508.44  E-value: 6.22e-178
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462489227  22 RSTSIIATIGPASRSVERLKEMIKAGMNIARLNFSHGSHEYHAESIANVREAVESfagsplSYRPVAIALDTKGPEIRTG 101
Cdd:PRK09206    2 KKTKIVCTIGPKTESEEMLTKLLDAGMNVMRLNFSHGDYAEHGQRIKNLRNVMSK------TGKKAAILLDTKGPEIRTM 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462489227 102 ILQGGpeSEVELVKGSQVLVTVDPAFRtrGNANTVWVDYPNIVRVVPVGGRIYIDDGLISLVVQKIGPEGLVTQVENGGV 181
Cdd:PRK09206   76 KLEGG--NDVSLKAGQTFTFTTDKSVV--GNKERVAVTYEGFTADLSVGNTVLVDDGLIGMEVTAITGNEVICKVLNNGD 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462489227 182 LGSRKGVNLPGAQVDLPGLSEQDVRDLRFGVEHGVDIVFASFVRKASDVAAVRAALGPE-GHGIKIISKIENHEGVKRFD 260
Cdd:PRK09206  152 LGENKGVNLPGVSIALPALAEKDKQDLIFGCEQGVDFVAASFIRKRSDVLEIREHLKAHgGENIQIISKIENQEGLNNFD 231

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462489227 261 EILEVSDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNLAGKPVVCATQMLESMITKPRPTRAETSDVANAVLDGADCIML 340
Cdd:PRK09206  232 EILEASDGIMVARGDLGVEIPVEEVIFAQKMMIEKCNRARKVVITATQMLDSMIKNPRPTRAEAGDVANAILDGTDAVML 311

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462489227 341 SGETAKGNFPVEAVKMQHAIAREAEAAVYHRqlFEELRRAAPLsrDPTEVTAIGAVEAAFKCCAAAIIVLTTTGRSAQLL 420
Cdd:PRK09206  312 SGESAKGKYPLEAVSIMATICERTDRVMNSR--LESNNDNRKL--RITEAVCRGAVETAEKLDAPLIVVATQGGKSARSV 387

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462489227 421 SRYRPRAAVIAVTRSAQAARQVHLCRGVFPLLYREPpeaiwaDDVDRRVQFGIESGKLRGFLRVGDLVIVVTGWRPGSGY 500
Cdd:PRK09206  388 RKYFPDATILALTTNEKTARQLVLSKGVVPQLVKEI------ASTDDFYRLGKELALQSGLAQKGDVVVMVSGALVPSGT 461


                  ....*.
gi 2462489227 501 TNIMRV 506
Cdd:PRK09206  462 TNTASV 467
PRK06354 PRK06354
pyruvate kinase; Provisional
 22-506 3.94e-175

pyruvate kinase; Provisional


Pssm-ID: 235784 [Multi-domain]  Cd Length: 590  Bit Score: 505.62  E-value: 3.94e-175
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462489227  22 RSTSIIATIGPASRSVERLKEMIKAGMNIARLNFSHGSHEYHAESIANVREAVESFAgsplsyRPVAIALDTKGPEIRTG 101
Cdd:PRK06354    8 RRTKIVATIGPASESPEKLRQLIEAGATTARLNFSHGDHEEHGARIKNIREASKKLG------KTVGILQDLQGPKIRLG 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462489227 102 ILQGGPeseVELVKGSQVLVTVDPafrTRGNANTVWVDYPNIVRVVPVGGRIYIDDGLISLVVQKIGPEG--LVTQVENG 179
Cdd:PRK06354   82 RFEDGP---IELKTGDEFILTSRE---VLGTQEKFSVTYDGLADEVPVGSRILLDDGLIELEVEEVDKADgeLHCKVLVG 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462489227 180 GVLGSRKGVNLPGAQVDLPGLSEQDVRDLRFGVEHGVDIVFASFVRKASDVAAVRAALGPE-GHGIKIISKIENHEGVKR 258
Cdd:PRK06354  156 GVLSNKKGVNFPGVSLSLPAITEKDREDLIFGLEQGVDWIALSFVRNPSDVLEIRELIEEHnGKHIPIIAKIEKQEAIDN 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462489227 259 FDEILEVSDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNLAGKPVVCATQMLESMITKPRPTRAETSDVANAVLDGADCI 338
Cdd:PRK06354  236 IDAILELCDGLMVARGDLGVEIPAEEVPLLQKRLIKKANRLGKPVITATQMLDSMQRNPRPTRAEASDVANAILDGTDAV 315

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462489227 339 MLSGETAKGNFPVEAVKMQHAIAREAEAAVYHRQLFEELRRAaplsrDPTEVTAIG-AV-EAAFKCCAAAIIVLTTTGRS 416
Cdd:PRK06354  316 MLSNETAAGDYPVEAVQTMATIAVRIEKDLPYRDILSKRPEF-----TTTITNAISqAVsHIALQLDAAAIVTLTKSGAT 390

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462489227 417 AQLLSRYRPRAAVIAVTRSAQAARQVHLCRGVFPLLYREPPEAiwaddvDRRVQFGIESGKLRGFLRVGDLVIVVTGWRP 496
Cdd:PRK06354  391 ARNVSKYRPKTPILAVTPNESVARRLQLVWGVTPLLVLDAPST------DETFDAAINVAQESGLLKQGDLVVITAGTLV 464

                         490
                  ....*....|.
gi 2462489227 497 G-SGYTNIMRV 506
Cdd:PRK06354  465 GeSGSTDLMKV 475
PTZ00300 PTZ00300
pyruvate kinase; Provisional
 48-510 5.94e-173

pyruvate kinase; Provisional


Pssm-ID: 140321 [Multi-domain]  Cd Length: 454  Bit Score: 494.95  E-value: 5.94e-173
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462489227  48 MNIARLNFSHGSHEYHAESIANVREAVESFAGSplsyrpVAIALDTKGPEIRTGILQGGpesEVELVKGSQVLVTVDPAF 127
Cdd:PTZ00300    1 MSVARMNFSHGSHEYHQTTINNVRQAAAELGVN------IAIALDTKGPEIRTGLFVGG---EAVMERGATCYVTTDPAF 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462489227 128 RTRGNANTVWVDYPNIVRVVPVGGRIYIDDGLISLVVQKIGPE-GLVTQVENGGVLGSRKGVNLPGAQVDLPGLSEQDVR 206
Cdd:PTZ00300   72 ADKGTKDKFYIDYQNLSKVVRPGGYIYIDDGILILHVQSHEDEqTLKCTVTNAHTISDRRGVNLPGCDVDLPAVSAKDCA 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462489227 207 DLRFGVEHGVDIVFASFVRKASDVAAVRAALGPEGHGIKIISKIENHEGVKRFDEILEVSDGIMVARGDLGIEIPAEKVF 286
Cdd:PTZ00300  152 DLQFGVEQGVDMIFASFIRSAEQVGEVRKALGAKGGDIMIICKIENHQGVQNIDSIIEESDGIMVARGDLGVEIPAEKVV 231

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462489227 287 LAQKMMIGRCNLAGKPVVCATQMLESMITKPRPTRAETSDVANAVLDGADCIMLSGETAKGNFPVEAVKMQHAIAREAEA 366
Cdd:PTZ00300  232 VAQKILISKCNVAGKPVICATQMLESMTYNPRPTRAEVSDVANAVFNGADCVMLSGETAKGKYPNEVVQYMARICLEAQS 311

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462489227 367 AVYHRQLFEELRRAAPLSRDPTEVTAIGAVEAAFKCCAAAIIVLTTTGRSAQLLSRYRPRAAVIAVTRSAQAARQVHLCR 446
Cdd:PTZ00300  312 AVNEYVFFNSIKKLQPIPMSAEEAVCSSAVNSVYETKAKALVVLSNTGRSARLVAKYRPNCPIVCVTTRLQTCRQLNITQ 391

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2462489227 447 GVFPLLYrePPEAIWADD-VDRRVQFGIESGKLRGFLRVGDLVIVVTGWRPGSGYTNIMRVLSIS 510
Cdd:PTZ00300  392 GVESVFF--DAERLGHDEgKEQRVAMGVGFAKSKGYVQSGDLMVVVHADHKVKGYANQTRIILVS 454
PTZ00066 PTZ00066
pyruvate kinase; Provisional
 3-509 1.06e-167

pyruvate kinase; Provisional


Pssm-ID: 173361 [Multi-domain]  Cd Length: 513  Bit Score: 483.88  E-value: 1.06e-167
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462489227   3 DTFLEHLCLLDIDSepvaaRSTSIIATIGPASRSVERLKEMIKAGMNIARLNFSHGSHEYHAESIANVREAVESfagspl 82
Cdd:PTZ00066   24 DKILEPISDNDLRQ-----KKTHIVCTMGPACKNVETLVKLIDAGMNICRFNFSHGDHESHKKTLNNVREAAKA------ 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462489227  83 syRP---VAIALDTKGPEIRTGILQGGpeSEVELVKGSQVLVTVDPAFRtrGNANTVWVDYPNIVRVVPVGGRIYIDDGL 159
Cdd:PTZ00066   93 --RPnanLGILLDTKGPEIRTGFLKNH--KPITLKEGQTLKITTDYTFL--GDETCISCSYKKLPQSVKVGNIILIADGS 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462489227 160 ISLVVQKIGPEGLVTQVENGGVLGSRKGVNLPGAQVDLPGLSEQDVRD-LRFGVEHGVDIVFASFVRKASDVAAVRAALG 238
Cdd:PTZ00066  167 LSCKVLEVHDDYIITKVLNNATIGERKNMNLPGVKVELPVIGEKDKNDiLNFAIPMGCDFIALSFVQSADDVRLCRQLLG 246

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462489227 239 PEGHGIKIISKIENHEGVKRFDEILEVSDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNLAGKPVVCATQMLESMITKPR 318
Cdd:PTZ00066  247 ERGRHIKIIPKIENIEGLINFDEILAESDGIMVARGDLGMEIPPEKVFLAQKMMISKCNVAGKPVITATQMLESMIKNPR 326

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462489227 319 PTRAETSDVANAVLDGADCIMLSGETAKGNFPVEAVKMQHAIAREAEAAVYHRQLFEELRRAAPLSRDPTEVTAIGAVEA 398
Cdd:PTZ00066  327 PTRAESTDVANAVLDGTDCVMLSGETANGKFPVEAVNIMAKICFEAETCIDYRVLYHAIHLAVPTPVSVQEAVARSAVET 406

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462489227 399 AFKCCAAAIIVLTTTGRSAQLLSRYRPRAAVIAVTRSAQAARQVHLCRGVFPLLYREppeaiwADDVDRRVQFGIESGKL 478
Cdd:PTZ00066  407 AEDINAKLIIALTETGNTARLISKYRPSCTILALSASPSVVKSLSVARGVTTYVVNS------FQGTDVVIRNAIALAKE 480

                         490       500       510
                  ....*....|....*....|....*....|..
gi 2462489227 479 RGFLRVGDLVIVVTGWRPG-SGYTNIMRVLSI 509
Cdd:PTZ00066  481 RGLVESGDSAIAVHGVKEEvAGSSNLMKVVKI 512
PRK06247 PRK06247
pyruvate kinase; Provisional
 21-510 5.54e-142

pyruvate kinase; Provisional


Pssm-ID: 180487 [Multi-domain]  Cd Length: 476  Bit Score: 417.02  E-value: 5.54e-142
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462489227  21 ARSTSIIATIGPASRSVERLKEMIKAGMNIARLNFSHGSHEYHAESIANVREaVESFAGsplsyRPVAIALDTKGPEIRT 100
Cdd:PRK06247    4 NRRVKILATLGPASSSEDMIRKLVEAGADVFRLNFSHGDHDDHRELYKRIRE-VEDETG-----RPIGILADLQGPKLRL 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462489227 101 GILQGGPeseVELVKGSQVLVTVDPafrTRGNANTVWVDYPNIVRVVPVGGRIYIDDGLISLVVQKIGPEGLVTQVENGG 180
Cdd:PRK06247   78 GRFADGK---VQLANGQTFRLDVDD---APGDHDRVSLPHPEIAAALKPGDRLLVDDGKVRLVVEACDGDDVVCRVVEGG 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462489227 181 VLGSRKGVNLPGAQVDLPGLSEQDVRDLRFGVEHGVDIVFASFVRKASDVAAVRAAlgpEGHGIKIISKIENHEGVKRFD 260
Cdd:PRK06247  152 PVSDRKGVSLPGTVLSVSALTEKDRADLEFALELGVDWVALSFVQRPEDVEEVRKI---IGGRVPVMAKIEKPQAIDRLE 228

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462489227 261 EILEVSDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNLAGKPVVCATQMLESMITKPRPTRAETSDVANAVLDGADCIML 340
Cdd:PRK06247  229 AIVEASDAIMVARGDLGVEVPLEQVPLIQKRIIRAARRAGKPVVVATQMLESMIENPVPTRAEVSDVATAVLDGADAVML 308

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462489227 341 SGETAKGNFPVEAVKMQHAIAREAEAAVYHRQLFEelrraapLSRDPTEVTAIGAVEAAFKCCA-----AAIIVLTTTGR 415
Cdd:PRK06247  309 SAETASGKYPVEAVRTMARIIRQVERDPTYPPLIH-------AQRPQPEATKRDAISYAARDIAerldlAALVAYTSSGD 381

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462489227 416 SAQLLSRYRPRAAVIAVTRSAQAARQVHLCRGVFPLLYREppeaiwADDVDRRVQFGIESGKLRGFLRVGDLVIVVTGWR 495
Cdd:PRK06247  382 TALRAARERPPLPILALTPNPETARRLALTWGVHCVVVDD------ARDTDDMVRRADRIALAEGFYKRGDRVVIVAGVP 455

                         490
                  ....*....|....*.
gi 2462489227 496 PG-SGYTNIMRVLSIS 510
Cdd:PRK06247  456 PGtPGSTNMLRIAYIG 471
PLN02765 PLN02765
pyruvate kinase
 24-490 4.57e-117

pyruvate kinase


Pssm-ID: 215409 [Multi-domain]  Cd Length: 526  Bit Score: 354.75  E-value: 4.57e-117
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462489227  24 TSIIATIGPASRSVERLKEMIKAGMNIARLNFSHGSHEYHAESIANVREAVESfagsplSYRPVAIALDTKGPEIrtgIL 103
Cdd:PLN02765   30 TKIVGTLGPKSRSVEVIEACLKAGMSVARFDFSWGDAEYHQETLENLKIAVKN------TKKLCAVMLDTVGPEL---QV 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462489227 104 QGGPESEVELVKGSQVLVTVD---PAfrtrgNANTVWVDYPNIVRVVPVGGRIYIDDGLIS--------LVVQKIGPEGL 172
Cdd:PLN02765  101 INKTEKPISLKAGNTVTLTPDqskEA-----SSEVLPINFPGLAKAVKPGDTIFVGQYLFTgsettsvwLEVDEVKGDDV 175

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462489227 173 VTQVENGGVL-GSRKGVNLPGAQVDLPGLSEQDVRDLR-FGVEHGVDIVFASFVRKASDVAAVRAALGPEG-HGIKIISK 249
Cdd:PLN02765  176 VCTVKNSATLaGSLFTLHVSQVRIDLPTLSEKDKEVIStWGVPNKIDFLSLSYTRHAEDVREAREFLSSLGlSQTQIFAK 255

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462489227 250 IENHEGVKRFDEILEVSDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNLAGKPVVcATQMLESMITKPRPTRAETSDVAN 329
Cdd:PLN02765  256 IENVEGLTHFDEILQEADGIILSRGNLGIDLPPEKVFLFQKAALYKCNMAGKPAV-VTRVVDSMTDNLRPTRAEATDVAN 334

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462489227 330 AVLDGADCIMLSGETAKGNFPVEAVKMQHAIAREAEaAVYHRQLFeeLRRAAPLSRDP---TEVTAIGAVEAAFKCCAAA 406
Cdd:PLN02765  335 AVLDGADAILLGAETLRGLYPVETISTVGRICAEAE-KVFNQDLY--FKKTVKYVGEPmshLESIASSAVRAAIKVKASV 411

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462489227 407 IIVLTTTGRSAQLLSRYRPRAAVIAVT-------------RSAQAARQVHLCRGVFPLLY--REPPEAIWADDvDRRVQF 471
Cdd:PLN02765  412 IIVFTSSGRAARLIAKYRPTMPVLSVViprlktnqlkwsfTGAFQARQCLIVRGLFPMLAdpRHSAESTSATN-ESVLKV 490

                         490
                  ....*....|....*....
gi 2462489227 472 GIESGKLRGFLRVGDLVIV 490
Cdd:PLN02765  491 ALDHGKAAGVIKSHDRVVV 509
PLN02623 PLN02623
pyruvate kinase
 16-505 5.12e-103

pyruvate kinase


Pssm-ID: 215334 [Multi-domain]  Cd Length: 581  Bit Score: 320.34  E-value: 5.12e-103
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462489227  16 SEPVAARSTSIIATIGPASRSVERLKEMIKAGMNIARLNFSHGSHEYHAESIANVREAVESFAGSPlsyrpVAIALDTKG 95
Cdd:PLN02623  104 SKPSVRRKTKIVCTIGPSTNTREMIWKLAEAGMNVARLNMSHGDHASHQKVIDLVKEYNAQSKDNV-----IAIMLDTKG 178

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462489227  96 PEIRTGILqggPESeVELVKGSQVLVTVDpafRTRGNANTVWVDYPNIVRVVPVGGRIYIDDGLISLVVQKIGPEGLVTQ 175
Cdd:PLN02623  179 PEVRSGDL---PQP-IMLEEGQEFTFTIK---RGVSTEDCVSVNYDDFVNDVEVGDMLLVDGGMMSLAVKSKTSDSVKCE 251

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462489227 176 VENGGVLGSRKGVNLPGAQVDLPGLSEQDVRDLRFGVEHGVDIVFASFVRKASDVAAVRAALGPEGHGIKIISKIENHEG 255
Cdd:PLN02623  252 VVDGGELKSRRHLNVRGKSATLPSITEKDWEDIKFGVENKVDFYAVSFVKDAQVVHELKDYLKSCNADIHVIVKIESADS 331

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462489227 256 VKRFDEILEVSDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNLAGKPVVCATQMLESMITKPRPTRAETSDVANAVLDGA 335
Cdd:PLN02623  332 IPNLHSIITASDGAMVARGDLGAELPIEEVPLLQEEIIRRCRSMGKPVIVATNMLESMIVHPTPTRAEVSDIAIAVREGA 411

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462489227 336 DCIMLSGETAKGNFPVEAVKMQHAIAREAEAAVYHRQLFEELRRAAPlsRDPTEVTAIGAVEAAfKCCAAAIIVLTTTGR 415
Cdd:PLN02623  412 DAVMLSGETAHGKFPLKAVKVMHTVALRTEATLPEGTTPPNLGQAFK--NHMSEMFAFHATMMA-NTLGTSIIVFTRTGF 488

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462489227 416 SAQLLSRYRPRAAVIAVTRSAQAARQVHLCRGVFPlLYREppeaiWADDVDRRVQFGIESGKLRGFLRVGDLVIVVTgwr 495
Cdd:PLN02623  489 MAILLSHYRPSGTIFAFTNEKRIQQRLALYQGVCP-IYMQ-----FSDDAEETFARALSLLLNKGMVKEGEEVALVQ--- 559

                         490
                  ....*....|
gi 2462489227 496 pgSGYTNIMR 505
Cdd:PLN02623  560 --SGRQPIWR 567
PRK06739 PRK06739
pyruvate kinase; Validated
 27-365 6.59e-95

pyruvate kinase; Validated


Pssm-ID: 180676 [Multi-domain]  Cd Length: 352  Bit Score: 291.85  E-value: 6.59e-95
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462489227  27 IATIGPASRSVERLKEMIKAGMNIARLNFSHGSHEYHAESIANVREAVESfagsplsyrpVAIALDTKGPEIRTGILQGg 106
Cdd:PRK06739    6 ICTIGPASNNKETLAQLINNGMKIVRLNLSHGTHESHKDIIRLVKSLDDS----------IKILGDVQGPKIRLGEIKG- 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462489227 107 peSEVELVKGSQVLVTVDPafrTRGNANTVWVDYPNIVRVVPVGGRIYIDDGLISLVVQKIGPEGLVTQVENGGVLGSRK 186
Cdd:PRK06739   75 --EQITLQAGDSFILHTQP---VTGSSTEASVDYEGIANDVKVGSRILMNDGEVELIVEKVSTDKIETKVKTGGNISSHK 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462489227 187 GVNLPGAQVDLPGLSEQDVRDLRFGVEHGVDIVFASFVRKASDVAAVRAALGP-EGHGIKIISKIENHEGVKRFDEILEV 265
Cdd:PRK06739  150 GVNLPGAIVRLPAITEKDKKDIQFLLEEDVDFIACSFVRKPSHIKEIRDFIQQyKETSPNLIAKIETMEAIENFQDICKE 229

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462489227 266 SDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNLAGKPVVCATQMLESMITKPRPTRAETSDVANAVLDGADCIMLSGETA 345
Cdd:PRK06739  230 ADGIMIARGDLGVELPYQFIPLLQKMMIQECNRTNTYVITATQMLQSMVDHSIPTRAEVTDVFQAVLDGTNAVMLSAESA 309

                         330       340
                  ....*....|....*....|
gi 2462489227 346 KGNFPVEAVKMQHAIAREAE 365
Cdd:PRK06739  310 SGEHPIESVSTLRLVSEFAE 329
PLN02762 PLN02762
pyruvate kinase complex alpha subunit
 21-503 8.03e-89

pyruvate kinase complex alpha subunit


Pssm-ID: 215407 [Multi-domain]  Cd Length: 509  Bit Score: 281.63  E-value: 8.03e-89
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462489227  21 ARSTSIIATIGPASRSVERLKEMIKAGMNIARLNFSHGSHEYHAESIANVRE--AVESFAgsplsyrpVAIALDTKGPEI 98
Cdd:PLN02762   24 TRRTKLVCTIGPACCGFEQLEALAMGGMNVARLNMCHGTREWHRDVIRRVRRlnEEKGFA--------VAVMMDTEGSEI 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462489227  99 RTGILQGGPESEVElvKGSQVLVTVDpAFRTRGNANTVWVDYPNIVRVVPVGGRIYIDDGLISL-VVQKIGPEgLVTQVE 177
Cdd:PLN02762   96 HMGDLGGASSAKAE--DGEEWTFTVR-KFDGSRPEFTIQVNYDGFAEDVKVGDELVVDGGMVRFeVIEKIGPD-VKCKCT 171

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462489227 178 NGGVLGSRKGVNL--PGAQVD-----LPGLSEQDVRDLRFGVEHGVDIVFASFVRKASDVAAVR---AALGPEgHGIKII 247
Cdd:PLN02762  172 DPGLLLPRANLTFwrDGSLVRernamLPTISSKDWLDIDFGISEGVDFIAVSFVKSAEVIKHLKsyiAARSRD-SDIGVI 250

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462489227 248 SKIENHEGVKRFDEILEVSDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNLAGKPVVCATQMLESMITKPRPTRAETSDV 327
Cdd:PLN02762  251 AKIESLDSLKNLEEIIRASDGAMVARGDLGAQIPLEQVPSVQEKIVRLCRQLNKPVIVASQLLESMIEYPTPTRAEVADV 330

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462489227 328 ANAVLDGADCIMLSGETAKGNFPVEAVKMQHAIAREAEAAVYHRQLFEELRR---AAPLSRDPTEVTAIGAVEAAFKCCA 404
Cdd:PLN02762  331 SEAVRQRADALMLSGESAMGLYPEKALSVLRSVSLRMELWSREEKRHEALELpqlSSSLSDRISEEICNSAAKMANNLGV 410

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462489227 405 AAIIVLTTTGRSAQLLSRYRPRAAVIAVTRSAQAARQVHLCRGVFPLLYReppeaiWADDVDRRVQFGIESGKLRGFLRV 484
Cdd:PLN02762  411 DAIFVYTKHGHMASLLSRNRPDCPIFAFTDTTSVRRRLNLQWGLIPFRLD------FSDDMESNLNKTFSLLKARGMIKS 484

                         490
                  ....*....|....*....
gi 2462489227 485 GDLVIVVTGWRPGSGYTNI 503
Cdd:PLN02762  485 GDLVIAVSDLTPSSMLQSI 503
PRK08187 PRK08187
pyruvate kinase; Validated
 17-354 1.03e-56

pyruvate kinase; Validated


Pssm-ID: 236178  Cd Length: 493  Bit Score: 196.39  E-value: 1.03e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462489227  17 EPVAARSTSIIATI-GPASRSVERLKEMIKAGMNIARLNFSHGSHEYHAESIANVREAVESfAGsplsyRPVAIALDTKG 95
Cdd:PRK08187  128 PRPAARRTRIMVTLpSEAADDPDFVLRLAERGMDCARINCAHDDPAAWQAMIGHLRQAERA-TG-----RRCKILMDLAG 201

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462489227  96 PEIRTGILqGGPESEVELVKGSQVLVTVDPAF-RTRGNANTVWVDYPNIVRVVPVGGRIYIDDGLISLVVQKIGPEGLVT 174
Cdd:PRK08187  202 PKIRTGAV-AGPLGKTRLYTGDRLALVAQGPPrRIDEEHFQVTCTLPEILARLAVGARVWIDDGKLGARVERVGPGGALL 280

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462489227 175 QV----ENGGVLGSRKGVNLPGAQVDLPGLSEQDVRDLRFGVEHGvDIVFASFVRKASDVAAVRAAL----GPEGHGIKI 246
Cdd:PRK08187  281 EVtharPKGLKLKPEKGLNFPDTALDLPALTEKDRADLDFVARHA-DLVGYSFVQSPGDVEALQAALaarrPDDWRKLGL 359

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462489227 247 ISKIENHEGVKRFDEILEVSDG-----IMVARGDLGIEIPAEKVFLAQKMMIGRCNLAGKPVVCATQMLESMITKPRPTR 321
Cdd:PRK08187  360 VLKIETPRAVANLPELIVQAAGrqpfgVMIARGDLAVEIGFERLAEMQEEILWLCEAAHVPVIWATQVLEGLVKKGLPSR 439

                         330       340       350
                  ....*....|....*....|....*....|...
gi 2462489227 322 AETSDVANAvlDGADCIMLSgetaKGNFPVEAV 354
Cdd:PRK08187  440 AEMTDAAMA--ARAECVMLN----KGPYLVEAV 466
PRK14725 PRK14725
pyruvate kinase; Provisional
 37-379 1.29e-42

pyruvate kinase; Provisional


Pssm-ID: 237804  Cd Length: 608  Bit Score: 160.12  E-value: 1.29e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462489227  37 VERLkemIKAGMNIARLNFSHGSHEYHAESIANVREAVESFAgsplsyRPVAIALDTKGPEIRTGILQGGPE-------- 108
Cdd:PRK14725  158 VRRL---LAAGMDIARINCAHDDPEAWRAMIANVRTAEEELG------RRCRIAMDLAGPKLRTGPIAPGPRviklrptr 228

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462489227 109 ---------SEVELVKGS---------QVLVTVDPAF-------------RTRG-------------------------- 131
Cdd:PRK14725  229 dalgrvltpARLWLTASEspppspppgPVGLPVDPEWlarlepgdelrftDARGkkrkltvtevddegvlaegsqtayla 308

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462489227 132 NANTVWVDY-------------------------------------------------PNIVRVVPVGGRIYIDDGLISL 162
Cdd:PRK14725  309 NGTLLRLGRhdstrvgglppveqklrlkvgdrlvltrddapgdpaqgdapparisctlPEAFRAARVGERVWFDDGKIGA 388

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462489227 163 VVQKIGPEGL---VTQVENGGV-LGSRKGVNLPGAQVDLPGLSEQDVRDLRFGVEHGvDIVFASFVRKASDVAAVRAALg 238
Cdd:PRK14725  389 VVVKVEADEVelrITHARPGGSkLKAGKGINLPDSHLPLPALTDKDLEDLAFVAKHA-DIVALSFVRSPEDVRLLLDAL- 466

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462489227 239 pEGHGIK---IISKIENHEGVKRFDEIL-----EVSDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNLAGKPVVCATQML 310
Cdd:PRK14725  467 -EKLGADdlgVVLKIETRRAFENLPRILleamrHPRFGVMIARGDLAVEVGFERLAEVQEEILWLCEAAHVPVIWATQVL 545

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2462489227 311 ESMITKPRPTRAETSDVANAVLdgADCIMLSgetaKGNFPVEAVKMQHAIAREAEAavYHRQLFEELRR 379
Cdd:PRK14725  546 ESLAKKGLPSRAEITDAAMALR--AECVMLN----KGPHIVEAVRVLDDILRRMEE--HQRKKRSLLRR 606
PykA2 COG3848
Phosphohistidine swiveling domain of PEP-utilizing enzymes [Signal transduction mechanisms];
295-506 2.16e-40

Phosphohistidine swiveling domain of PEP-utilizing enzymes [Signal transduction mechanisms];


Pssm-ID: 443058  Cd Length: 321  Bit Score: 148.12  E-value: 2.16e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462489227 295 RCNLAGKPVVCATQMLESMITKPRPTRAETSDVANAVLDGADCIMLSGETAKGNFPVEAVKMQHAIAREAEAAVYHRqlf 374
Cdd:COG3848     1 KCNAAGKPVITATQMLDSMMRNPRPTRAEAADVANAIFDGTDAIMLSGETAAGKYPVEAVVTMVRIAERAEEDLEYR--- 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462489227 375 eELRRAAPLSRDPTEVTAIG--AVEAAFKCCAAAIIVLTTTGRSAQLLSRYRPRAAVIAVTRSAQAARQVHLCRGVFPLL 452
Cdd:COG3848    78 -EQRVPRAKESSTTITDAIShaVATTAADLGAAAIITATESGATARMVSKYRPKAPIIAVTPSERVARQLSLVWGVYPLL 156

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2462489227 453 YREPPEAIwaDDVDRRVQFGIESgklrGFLRVGDLVIVVTGWRPG-SGYTNIMRV 506
Cdd:COG3848   157 VEESASTD--EMFAVAVALALEA----GLVKDGDLVVITAGVPVGvSGTTNLLKV 205
PK_C pfam02887
Pyruvate kinase, alpha/beta domain; As well as being found in pyruvate kinase this family is ...
 389-507 2.09e-35

Pyruvate kinase, alpha/beta domain; As well as being found in pyruvate kinase this family is found as an isolated domain in some bacterial proteins.


Pssm-ID: 460738 [Multi-domain]  Cd Length: 114  Bit Score: 127.98  E-value: 2.09e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462489227 389 EVTAIGAVEAAFKCCAAAIIVLTTTGRSAQLLSRYRPRAAVIAVTRSAQAARQVHLCRGVFPLLYREppeaiwADDVDRR 468
Cdd:pfam02887   1 EAIAHAAVEAAEELGAKAIVVLTESGYTARLISRYRPGVPIIAVTPNELTARQLALYWGVYPVLFDE------AETTDEM 74

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 2462489227 469 VQFGIESGKLRGFLRVGDLVIVVTGWRPG-SGYTNIMRVL 507
Cdd:pfam02887  75 LRRAVKVAKEAGLVKKGDLVVITAGVPFGvSGTTNTLKVI 114
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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