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Conserved domains on  [gi|2462497869|ref|XP_054187674|]
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low-density lipoprotein receptor-related protein 6 isoform X1 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 215-256 1.73e-12

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 63.00  E-value: 1.73e-12
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 2462497869   215 VLVNTSLGWPNGLALDYDEGKIYWGDAKTDKIEVMNTDGTGR 256
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 129-169 4.34e-12

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 61.85  E-value: 4.34e-12
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 2462497869   129 VVTAQIAHPDGIAVDWVARNLYWTDTGTDRIEVTRLNGTMR 169
Cdd:smart00135    3 LLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1058-1092 4.63e-12

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 61.45  E-value: 4.63e-12
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 2462497869 1058 CLIDQFRCANGQCIGKHKKCDHNVDCSDKSDELDC 1092
Cdd:cd00112      1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 324-359 4.97e-12

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


:

Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 61.49  E-value: 4.97e-12
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 2462497869  324 CAEENGGCSHLCLYRPQGLRCACPIGFELISDMKTC 359
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 190-231 6.58e-12

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


:

Pssm-ID: 459654  Cd Length: 42  Bit Score: 61.02  E-value: 6.58e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 2462497869  190 GYMYWTDWGEIPKIERAALDGSDRVVLVNTSLGWPNGLALDY 231
Cdd:pfam00058    1 GRLYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1020-1054 7.69e-12

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 60.68  E-value: 7.69e-12
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 2462497869 1020 CSESQFQCASGQCIDGALRCNGDANCQDKSDEKNC 1054
Cdd:cd00112      1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 429-471 2.40e-11

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 59.54  E-value: 2.40e-11
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 2462497869   429 EHVVEFGLDYPEGMAVDWLGKNLYWADTGTNRIEVSKLDGQHR 471
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
386-545 6.43e-11

DNA-binding beta-propeller fold protein YncE [General function prediction only];


:

Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 63.94  E-value: 6.43e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462497869  386 VAIPLTGVKEASALDFDVTDNRIYWTDISLKTISRAFMNGSALEHVVEFGlDYPEGMAVDWLGKNLYWADTGTNRieVSK 465
Cdd:COG3391     60 LGLGAAAVADADGADAGADGRRLYVANSGSGRVSVIDLATGKVVATIPVG-GGPRGLAVDPDGGRLYVADSGNGR--VSV 136

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462497869  466 LDGQHRQVL-VWKDLDSPRALALDPAEGFMYWTEWGGKP------KIDRAAMdgsERTTLVPNVGRANGLTIDYAKRRLY 538
Cdd:COG3391    137 IDTATGKVVaTIPVGAGPHGIAVDPDGKRLYVANSGSNTvsvivsVIDTATG---KVVATIPVGGGPVGVAVSPDGRRLY 213


                   ....*..
gi 2462497869  539 WTDLDTN 545
Cdd:COG3391    214 VANRGSN 220
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 18-55 7.52e-11

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


:

Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 58.02  E-value: 7.52e-11
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 2462497869   18 CGIDNGGCSHLCLMSPVKpfYQCACPTGVKLLENGKTC 55
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGG--YTCSCPEGYELQDDGRTC 36
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 625-661 8.88e-11

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


:

Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 58.02  E-value: 8.88e-11
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 2462497869  625 CASSNGHCSHLCLAVPvGGFVCGCPAHYSLNADNRTC 661
Cdd:pfam14670    1 CSVNNGGCSHLCLNTP-GGYTCSCPEGYELQDDGRTC 36
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 981-1017 4.18e-10

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 56.06  E-value: 4.18e-10
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 2462497869  981 CSPQQFTCFTGEidCIPVAWRCDGFTECEDHSDELNC 1017
Cdd:cd00112      1 CPPNEFRCANGR--CIPSSWVCDGEDDCGDGSDEENC 35
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 939-975 3.05e-08

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


:

Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 50.70  E-value: 3.05e-08
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 2462497869  939 CAQDNGGCSHICLVKGDGTTrCSCPMHLVLLQDELSC 975
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYT-CSCPEGYELQDDGRTC 36
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 85-125 2.09e-07

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 48.37  E-value: 2.09e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 2462497869    85 VLQLEDIRHAIAIDYDPVEGYIYWTDDEVRAIRRSFIDGSG 125
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTN 42
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 826-868 3.72e-07

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 47.60  E-value: 3.72e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 2462497869   826 EVLFFSGLSKPIALALDSRLGKLFWADSDLRRIESSDLSGANR 868
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 559-598 5.24e-05

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 41.82  E-value: 5.24e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 2462497869   559 VIADDLPHPFGLT--QYQDYIYWTDWSRRSIERANKTsGQNR 598
Cdd:smart00135    3 LLSSGLGHPNGLAvdWIEGRLYWTDWGLDVIEVANLD-GTNR 43
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 690-730 1.77e-04

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 40.28  E-value: 1.77e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 2462497869   690 ILPIHSLRNVRAIDYDPLDKQLYWIDSRQNMIRKAQEDGSQ 730
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTN 42
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 257-290 1.92e-04

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 40.28  E-value: 1.92e-04
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 2462497869   257 RVLVEDKIPHIFGFTL--LGDYVYWTDWQRRSIERV 290
Cdd:smart00135    1 RTLLSSGLGHPNGLAVdwIEGRLYWTDWGLDVIEVA 36
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
700-807 5.20e-04

DNA-binding beta-propeller fold protein YncE [General function prediction only];


:

Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 43.14  E-value: 5.20e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462497869  700 RAIDYDPLDKQLYWIDSRQNMIRKAqeDGSQGftVVVSSVPsqnLEIQPYDLSIDIYSRYIYWTCEATN---VInVTRLD 776
Cdd:COG3391    113 RGLAVDPDGGRLYVADSGNGRVSVI--DTATG--KVVATIP---VGAGPHGIAVDPDGKRLYVANSGSNtvsVI-VSVID 184

                           90       100       110
                   ....*....|....*....|....*....|...
gi 2462497869  777 GRSvGVVLK--GEQDRPRAVVVNPEKGYMYFTN 807
Cdd:COG3391    185 TAT-GKVVAtiPVGGGPVGVAVSPDGRRLYVAN 216
 
Name Accession Description Interval E-value
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 215-256 1.73e-12

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 63.00  E-value: 1.73e-12
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 2462497869   215 VLVNTSLGWPNGLALDYDEGKIYWGDAKTDKIEVMNTDGTGR 256
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 129-169 4.34e-12

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 61.85  E-value: 4.34e-12
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 2462497869   129 VVTAQIAHPDGIAVDWVARNLYWTDTGTDRIEVTRLNGTMR 169
Cdd:smart00135    3 LLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1058-1092 4.63e-12

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 61.45  E-value: 4.63e-12
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 2462497869 1058 CLIDQFRCANGQCIGKHKKCDHNVDCSDKSDELDC 1092
Cdd:cd00112      1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 324-359 4.97e-12

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 61.49  E-value: 4.97e-12
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 2462497869  324 CAEENGGCSHLCLYRPQGLRCACPIGFELISDMKTC 359
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 190-231 6.58e-12

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 61.02  E-value: 6.58e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 2462497869  190 GYMYWTDWGEIPKIERAALDGSDRVVLVNTSLGWPNGLALDY 231
Cdd:pfam00058    1 GRLYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1020-1054 7.69e-12

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 60.68  E-value: 7.69e-12
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 2462497869 1020 CSESQFQCASGQCIDGALRCNGDANCQDKSDEKNC 1054
Cdd:cd00112      1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 429-471 2.40e-11

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 59.54  E-value: 2.40e-11
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 2462497869   429 EHVVEFGLDYPEGMAVDWLGKNLYWADTGTNRIEVSKLDGQHR 471
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
386-545 6.43e-11

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 63.94  E-value: 6.43e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462497869  386 VAIPLTGVKEASALDFDVTDNRIYWTDISLKTISRAFMNGSALEHVVEFGlDYPEGMAVDWLGKNLYWADTGTNRieVSK 465
Cdd:COG3391     60 LGLGAAAVADADGADAGADGRRLYVANSGSGRVSVIDLATGKVVATIPVG-GGPRGLAVDPDGGRLYVADSGNGR--VSV 136

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462497869  466 LDGQHRQVL-VWKDLDSPRALALDPAEGFMYWTEWGGKP------KIDRAAMdgsERTTLVPNVGRANGLTIDYAKRRLY 538
Cdd:COG3391    137 IDTATGKVVaTIPVGAGPHGIAVDPDGKRLYVANSGSNTvsvivsVIDTATG---KVVATIPVGGGPVGVAVSPDGRRLY 213


                   ....*..
gi 2462497869  539 WTDLDTN 545
Cdd:COG3391    214 VANRGSN 220
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 18-55 7.52e-11

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 58.02  E-value: 7.52e-11
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 2462497869   18 CGIDNGGCSHLCLMSPVKpfYQCACPTGVKLLENGKTC 55
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGG--YTCSCPEGYELQDDGRTC 36
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 170-213 7.90e-11

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 58.00  E-value: 7.90e-11
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 2462497869   170 KILISEDLEEPRAIVLDPMVGYMYWTDWGEiPKIERAALDGSDR 213
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGL-DVIEVANLDGTNR 43
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 625-661 8.88e-11

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 58.02  E-value: 8.88e-11
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 2462497869  625 CASSNGHCSHLCLAVPvGGFVCGCPAHYSLNADNRTC 661
Cdd:pfam14670    1 CSVNNGGCSHLCLNTP-GGYTCSCPEGYELQDDGRTC 36
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
1020-1054 1.61e-10

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 57.26  E-value: 1.61e-10
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 2462497869 1020 CSESQFQCASGQCIDGALRCNGDANCQDKSDEKNC 1054
Cdd:pfam00057    3 CSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 981-1017 4.18e-10

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 56.06  E-value: 4.18e-10
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 2462497869  981 CSPQQFTCFTGEidCIPVAWRCDGFTECEDHSDELNC 1017
Cdd:cd00112      1 CPPNEFRCANGR--CIPSSWVCDGEDDCGDGSDEENC 35
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 1020-1051 8.16e-10

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 54.95  E-value: 8.16e-10
                            10        20        30
                    ....*....|....*....|....*....|..
gi 2462497869  1020 CSESQFQCASGQCIDGALRCNGDANCQDKSDE 1051
Cdd:smart00192    2 CPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 1058-1089 1.12e-09

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 54.56  E-value: 1.12e-09
                            10        20        30
                    ....*....|....*....|....*....|..
gi 2462497869  1058 CLIDQFRCANGQCIGKHKKCDHNVDCSDKSDE 1089
Cdd:smart00192    2 CPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 980-1014 2.82e-09

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 53.41  E-value: 2.82e-09
                            10        20        30
                    ....*....|....*....|....*....|....*
gi 2462497869   980 TCSPQQFTCFTGEidCIPVAWRCDGFTECEDHSDE 1014
Cdd:smart00192    1 TCPPGEFQCDNGR--CIPSSWVCDGVDDCGDGSDE 33
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 93-255 6.96e-09

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 58.48  E-value: 6.96e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462497869   93 HAIAIDYDpveGYIYWTDDEVRAIRR-----SFIDGSGSQFVVTAQIAHPDGIAVDwVARNLYWTDTGTDRIEVTRLNGT 167
Cdd:cd05819     58 AGVAVDSD---GNLYVADTGNHRIQKfdpdgNFLASFGGSGDGDGEFNGPRGIAVD-SSGNIYVADTGNHRIQKFDPDGE 133

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462497869  168 MRKIL-----ISEDLEEPRAIVLDPmVGYMYWTDWgeipkieraaldGSDRVVLVNT----------------SLGWPNG 226
Cdd:cd05819    134 FLTTFgsggsGPGQFNGPTGVAVDS-DGNIYVADT------------GNHRIQVFDPdgnflttfgstgtgpgQFNYPTG 200

                          170       180
                   ....*....|....*....|....*....
gi 2462497869  227 LALDyDEGKIYWGDAKTDKIEVMNTDGTG 255
Cdd:cd05819    201 IAVD-SDGNIYVADSGNNRVQVFDPDGAG 228
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
980-1017 1.01e-08

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 51.87  E-value: 1.01e-08
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 2462497869  980 TCSPQQFTCFTGEidCIPVAWRCDGFTECEDHSDELNC 1017
Cdd:pfam00057    2 TCSPNEFQCGSGE--CIPRSWVCDGDPDCGDGSDEENC 37
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 472-515 1.59e-08

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 51.83  E-value: 1.59e-08
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 2462497869   472 QVLVWKDLDSPRALALDPAEGFMYWTEWgGKPKIDRAAMDGSER 515
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDW-GLDVIEVANLDGTNR 43
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
93-260 1.77e-08

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 56.63  E-value: 1.77e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462497869   93 HAIAIDYDPVEGYIYWTDDEVRAIrrSFIDGSGSQFVVT-AQIAHPDGIAVDWVARNLYWTDTGTDRieVTRLNGTMRKI 171
Cdd:COG3391     69 DADGADAGADGRRLYVANSGSGRV--SVIDLATGKVVATiPVGGGPRGLAVDPDGGRLYVADSGNGR--VSVIDTATGKV 144

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462497869  172 LISEDL-EEPRAIVLDPMVGYMYWTDWG--EIPKIErAALDGSDRVVLVNTSLG-WPNGLALDYDEGKIYWGDAKTDKie 247
Cdd:COG3391    145 VATIPVgAGPHGIAVDPDGKRLYVANSGsnTVSVIV-SVIDTATGKVVATIPVGgGPVGVAVSPDGRRLYVANRGSNT-- 221

                          170
                   ....*....|...
gi 2462497869  248 vmnTDGTGRRVLV 260
Cdd:COG3391    222 ---SNGGSNTVSV 231
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
1058-1092 1.98e-08

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 51.10  E-value: 1.98e-08
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 2462497869 1058 CLIDQFRCANGQCIGKHKKCDHNVDCSDKSDELDC 1092
Cdd:pfam00057    3 CSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 939-975 3.05e-08

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 50.70  E-value: 3.05e-08
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 2462497869  939 CAQDNGGCSHICLVKGDGTTrCSCPMHLVLLQDELSC 975
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYT-CSCPEGYELQDDGRTC 36
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 147-187 5.76e-08

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 49.85  E-value: 5.76e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 2462497869  147 RNLYWTDTGTD-RIEVTRLNGTMRKILISEDLEEPRAIVLDP 187
Cdd:pfam00058    1 GRLYWTDSSLRaSISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 85-125 2.09e-07

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 48.37  E-value: 2.09e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 2462497869    85 VLQLEDIRHAIAIDYDPVEGYIYWTDDEVRAIRRSFIDGSG 125
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTN 42
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 826-868 3.72e-07

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 47.60  E-value: 3.72e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 2462497869   826 EVLFFSGLSKPIALALDSRLGKLFWADSDLRRIESSDLSGANR 868
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 492-532 9.05e-07

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 46.77  E-value: 9.05e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 2462497869  492 GFMYWTEWGGKPKIDRAAMDGSER-TTLVPNVGRANGLTIDY 532
Cdd:pfam00058    1 GRLYWTDSSLRASISSADLNGSDRkTLFTDDLQHPNAIAVDP 42
NHL_PKND_like cd14952
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ...
 431-545 1.11e-05

NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271322 [Multi-domain]  Cd Length: 247  Bit Score: 48.36  E-value: 1.11e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462497869  431 VVEF-GLDYPEGMAVDWLGkNLYWADTGTNRieVSKLD-GQHRQ-VLVWKDLDSPRALALDPAeGFMYWTEWGGKPKIDR 507
Cdd:cd14952      3 VLPFtGLDGPGGVAVDAAG-NVYVADSGNNR--VLKLAaGSTTQtVLPFTGLYQPQGVAVDAA-GTVYVTDFGNNRVLKL 78

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 2462497869  508 AAmdGSERTTLVP--NVGRANGLTIDyAKRRLYWTDLDTN 545
Cdd:cd14952     79 AA--GSTTQTVLPftGLNDPTGVAVD-AAGNVYVADTGNN 115
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 450-489 2.84e-05

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 42.53  E-value: 2.84e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 2462497869  450 NLYWADTGT-NRIEVSKLDGQHRQVLVWKDLDSPRALALDP 489
Cdd:pfam00058    2 RLYWTDSSLrASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 559-598 5.24e-05

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 41.82  E-value: 5.24e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 2462497869   559 VIADDLPHPFGLT--QYQDYIYWTDWSRRSIERANKTsGQNR 598
Cdd:smart00135    3 LLSSGLGHPNGLAvdWIEGRLYWTDWGLDVIEVANLD-GTNR 43
DUF5050 pfam16472
Domain of unknown function (DUF5050);
105-281 1.33e-04

Domain of unknown function (DUF5050);


Pssm-ID: 465128 [Multi-domain]  Cd Length: 282  Bit Score: 45.31  E-value: 1.33e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462497869  105 YIYWTDDEVRAIRRSFIDGSGSQFVVTAQIAHPDgIAVDWVarnlYWTDTGTD-RIEVTRLNGTMRKILISEDLEEPraI 183
Cdd:pfam16472  111 YQHYDNSDGGTLYKIKIDGKEKTKLSDEPISPAS-VSDGWI----YYSGTSDDhYIYKLNTDGDSISKLYDGNSYMP--N 183

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462497869  184 VLDpmvGYMYWTDWGEIPKIERAALDGSDRVVLVNTSLGWPNglaldYDEGKIYWGDAKTD-KIEVMNTDGTGRRVLVED 262
Cdd:pfam16472  184 VNG---DYIYYIDLSNNYALYRMNLSGGEKEVLTDDRVDNYN-----VYGNWIYYQNNGDDnKLYRINTDGSNKEKLAEG 255

                          170
                   ....*....|....*....
gi 2462497869  263 KIPHIfgfTLLGDYVYWTD 281
Cdd:pfam16472  256 NYTNI---NITSDYIYFTD 271
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 690-730 1.77e-04

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 40.28  E-value: 1.77e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 2462497869   690 ILPIHSLRNVRAIDYDPLDKQLYWIDSRQNMIRKAQEDGSQ 730
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTN 42
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 257-290 1.92e-04

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 40.28  E-value: 1.92e-04
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 2462497869   257 RVLVEDKIPHIFGFTL--LGDYVYWTDWQRRSIERV 290
Cdd:smart00135    1 RTLLSSGLGHPNGLAVdwIEGRLYWTDWGLDVIEVA 36
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 104-144 2.51e-04

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 39.84  E-value: 2.51e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 2462497869  104 GYIYWTDDEVRA-IRRSFIDGSGSQFVVTAQIAHPDGIAVDW 144
Cdd:pfam00058    1 GRLYWTDSSLRAsISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
700-807 5.20e-04

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 43.14  E-value: 5.20e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462497869  700 RAIDYDPLDKQLYWIDSRQNMIRKAqeDGSQGftVVVSSVPsqnLEIQPYDLSIDIYSRYIYWTCEATN---VInVTRLD 776
Cdd:COG3391    113 RGLAVDPDGGRLYVADSGNGRVSVI--DTATG--KVVATIP---VGAGPHGIAVDPDGKRLYVANSGSNtvsVI-VSVID 184

                           90       100       110
                   ....*....|....*....|....*....|...
gi 2462497869  777 GRSvGVVLK--GEQDRPRAVVVNPEKGYMYFTN 807
Cdd:COG3391    185 TAT-GKVVAtiPVGGGPVGVAVSPDGRRLYVAN 216
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 846-886 7.87e-04

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 38.29  E-value: 7.87e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 2462497869  846 GKLFWADSDLR-RIESSDLSGANRIVLEDSNILQPVGLTVFE 886
Cdd:pfam00058    1 GRLYWTDSSLRaSISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 436-502 4.32e-03

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 40.76  E-value: 4.32e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2462497869  436 LDYPEGMAVDWLGkNLYWADTGTNRIevSKLDGQHRQVLVW-------KDLDSPRALALDPAeGFMYWTEWGGK 502
Cdd:cd05819     54 FNEPAGVAVDSDG-NLYVADTGNHRI--QKFDPDGNFLASFggsgdgdGEFNGPRGIAVDSS-GNIYVADTGNH 123
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 747-780 7.04e-03

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 35.66  E-value: 7.04e-03
                            10        20        30
                    ....*....|....*....|....*....|....
gi 2462497869   747 QPYDLSIDIYSRYIYWTCEATNVINVTRLDGRSV 780
Cdd:smart00135   10 HPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
 
Name Accession Description Interval E-value
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 215-256 1.73e-12

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 63.00  E-value: 1.73e-12
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 2462497869   215 VLVNTSLGWPNGLALDYDEGKIYWGDAKTDKIEVMNTDGTGR 256
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 129-169 4.34e-12

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 61.85  E-value: 4.34e-12
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 2462497869   129 VVTAQIAHPDGIAVDWVARNLYWTDTGTDRIEVTRLNGTMR 169
Cdd:smart00135    3 LLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1058-1092 4.63e-12

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 61.45  E-value: 4.63e-12
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 2462497869 1058 CLIDQFRCANGQCIGKHKKCDHNVDCSDKSDELDC 1092
Cdd:cd00112      1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 324-359 4.97e-12

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 61.49  E-value: 4.97e-12
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 2462497869  324 CAEENGGCSHLCLYRPQGLRCACPIGFELISDMKTC 359
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 190-231 6.58e-12

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 61.02  E-value: 6.58e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 2462497869  190 GYMYWTDWGEIPKIERAALDGSDRVVLVNTSLGWPNGLALDY 231
Cdd:pfam00058    1 GRLYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1020-1054 7.69e-12

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 60.68  E-value: 7.69e-12
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 2462497869 1020 CSESQFQCASGQCIDGALRCNGDANCQDKSDEKNC 1054
Cdd:cd00112      1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 429-471 2.40e-11

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 59.54  E-value: 2.40e-11
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 2462497869   429 EHVVEFGLDYPEGMAVDWLGKNLYWADTGTNRIEVSKLDGQHR 471
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
386-545 6.43e-11

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 63.94  E-value: 6.43e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462497869  386 VAIPLTGVKEASALDFDVTDNRIYWTDISLKTISRAFMNGSALEHVVEFGlDYPEGMAVDWLGKNLYWADTGTNRieVSK 465
Cdd:COG3391     60 LGLGAAAVADADGADAGADGRRLYVANSGSGRVSVIDLATGKVVATIPVG-GGPRGLAVDPDGGRLYVADSGNGR--VSV 136

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462497869  466 LDGQHRQVL-VWKDLDSPRALALDPAEGFMYWTEWGGKP------KIDRAAMdgsERTTLVPNVGRANGLTIDYAKRRLY 538
Cdd:COG3391    137 IDTATGKVVaTIPVGAGPHGIAVDPDGKRLYVANSGSNTvsvivsVIDTATG---KVVATIPVGGGPVGVAVSPDGRRLY 213


                   ....*..
gi 2462497869  539 WTDLDTN 545
Cdd:COG3391    214 VANRGSN 220
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 18-55 7.52e-11

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 58.02  E-value: 7.52e-11
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 2462497869   18 CGIDNGGCSHLCLMSPVKpfYQCACPTGVKLLENGKTC 55
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGG--YTCSCPEGYELQDDGRTC 36
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 170-213 7.90e-11

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 58.00  E-value: 7.90e-11
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 2462497869   170 KILISEDLEEPRAIVLDPMVGYMYWTDWGEiPKIERAALDGSDR 213
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGL-DVIEVANLDGTNR 43
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 625-661 8.88e-11

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 58.02  E-value: 8.88e-11
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 2462497869  625 CASSNGHCSHLCLAVPvGGFVCGCPAHYSLNADNRTC 661
Cdd:pfam14670    1 CSVNNGGCSHLCLNTP-GGYTCSCPEGYELQDDGRTC 36
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
1020-1054 1.61e-10

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 57.26  E-value: 1.61e-10
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 2462497869 1020 CSESQFQCASGQCIDGALRCNGDANCQDKSDEKNC 1054
Cdd:pfam00057    3 CSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 981-1017 4.18e-10

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 56.06  E-value: 4.18e-10
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 2462497869  981 CSPQQFTCFTGEidCIPVAWRCDGFTECEDHSDELNC 1017
Cdd:cd00112      1 CPPNEFRCANGR--CIPSSWVCDGEDDCGDGSDEENC 35
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 1020-1051 8.16e-10

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 54.95  E-value: 8.16e-10
                            10        20        30
                    ....*....|....*....|....*....|..
gi 2462497869  1020 CSESQFQCASGQCIDGALRCNGDANCQDKSDE 1051
Cdd:smart00192    2 CPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 1058-1089 1.12e-09

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 54.56  E-value: 1.12e-09
                            10        20        30
                    ....*....|....*....|....*....|..
gi 2462497869  1058 CLIDQFRCANGQCIGKHKKCDHNVDCSDKSDE 1089
Cdd:smart00192    2 CPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 980-1014 2.82e-09

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 53.41  E-value: 2.82e-09
                            10        20        30
                    ....*....|....*....|....*....|....*
gi 2462497869   980 TCSPQQFTCFTGEidCIPVAWRCDGFTECEDHSDE 1014
Cdd:smart00192    1 TCPPGEFQCDNGR--CIPSSWVCDGVDDCGDGSDE 33
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 93-255 6.96e-09

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 58.48  E-value: 6.96e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462497869   93 HAIAIDYDpveGYIYWTDDEVRAIRR-----SFIDGSGSQFVVTAQIAHPDGIAVDwVARNLYWTDTGTDRIEVTRLNGT 167
Cdd:cd05819     58 AGVAVDSD---GNLYVADTGNHRIQKfdpdgNFLASFGGSGDGDGEFNGPRGIAVD-SSGNIYVADTGNHRIQKFDPDGE 133

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462497869  168 MRKIL-----ISEDLEEPRAIVLDPmVGYMYWTDWgeipkieraaldGSDRVVLVNT----------------SLGWPNG 226
Cdd:cd05819    134 FLTTFgsggsGPGQFNGPTGVAVDS-DGNIYVADT------------GNHRIQVFDPdgnflttfgstgtgpgQFNYPTG 200

                          170       180
                   ....*....|....*....|....*....
gi 2462497869  227 LALDyDEGKIYWGDAKTDKIEVMNTDGTG 255
Cdd:cd05819    201 IAVD-SDGNIYVADSGNNRVQVFDPDGAG 228
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
980-1017 1.01e-08

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 51.87  E-value: 1.01e-08
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 2462497869  980 TCSPQQFTCFTGEidCIPVAWRCDGFTECEDHSDELNC 1017
Cdd:pfam00057    2 TCSPNEFQCGSGE--CIPRSWVCDGDPDCGDGSDEENC 37
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 472-515 1.59e-08

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 51.83  E-value: 1.59e-08
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 2462497869   472 QVLVWKDLDSPRALALDPAEGFMYWTEWgGKPKIDRAAMDGSER 515
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDW-GLDVIEVANLDGTNR 43
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
93-260 1.77e-08

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 56.63  E-value: 1.77e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462497869   93 HAIAIDYDPVEGYIYWTDDEVRAIrrSFIDGSGSQFVVT-AQIAHPDGIAVDWVARNLYWTDTGTDRieVTRLNGTMRKI 171
Cdd:COG3391     69 DADGADAGADGRRLYVANSGSGRV--SVIDLATGKVVATiPVGGGPRGLAVDPDGGRLYVADSGNGR--VSVIDTATGKV 144

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462497869  172 LISEDL-EEPRAIVLDPMVGYMYWTDWG--EIPKIErAALDGSDRVVLVNTSLG-WPNGLALDYDEGKIYWGDAKTDKie 247
Cdd:COG3391    145 VATIPVgAGPHGIAVDPDGKRLYVANSGsnTVSVIV-SVIDTATGKVVATIPVGgGPVGVAVSPDGRRLYVANRGSNT-- 221

                          170
                   ....*....|...
gi 2462497869  248 vmnTDGTGRRVLV 260
Cdd:COG3391    222 ---SNGGSNTVSV 231
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
1058-1092 1.98e-08

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 51.10  E-value: 1.98e-08
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 2462497869 1058 CLIDQFRCANGQCIGKHKKCDHNVDCSDKSDELDC 1092
Cdd:pfam00057    3 CSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 939-975 3.05e-08

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 50.70  E-value: 3.05e-08
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 2462497869  939 CAQDNGGCSHICLVKGDGTTrCSCPMHLVLLQDELSC 975
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYT-CSCPEGYELQDDGRTC 36
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 147-187 5.76e-08

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 49.85  E-value: 5.76e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 2462497869  147 RNLYWTDTGTD-RIEVTRLNGTMRKILISEDLEEPRAIVLDP 187
Cdd:pfam00058    1 GRLYWTDSSLRaSISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 515-557 6.07e-08

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 49.91  E-value: 6.07e-08
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 2462497869   515 RTTLVPNVGRANGLTIDYAKRRLYWTDLDTNLIESSNMLGLNR 557
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 85-125 2.09e-07

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 48.37  E-value: 2.09e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 2462497869    85 VLQLEDIRHAIAIDYDPVEGYIYWTDDEVRAIRRSFIDGSG 125
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTN 42
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 826-868 3.72e-07

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 47.60  E-value: 3.72e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 2462497869   826 EVLFFSGLSKPIALALDSRLGKLFWADSDLRRIESSDLSGANR 868
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
93-281 7.44e-07

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 52.00  E-value: 7.44e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462497869   93 HAIAIDYDPVEGYIYWTDDEVRAIRRSFIDGSGSQFVVTAQIAHPDGIAVDWVARNLYWTDTGTDRIEV--TRLNGTMRK 170
Cdd:COG3391     26 AALGLGGGGPLLAAASGGVVGAAVGGGGVALLAGLGLGAAAVADADGADAGADGRRLYVANSGSGRVSVidLATGKVVAT 105

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462497869  171 ILISEDleePRAIVLDPMVGYMYWTDWGEiPKIerAALDGSDRVVLVNTSLG-WPNGLALDYDEGKIYWGDAKTDKI--- 246
Cdd:COG3391    106 IPVGGG---PRGLAVDPDGGRLYVADSGN-GRV--SVIDTATGKVVATIPVGaGPHGIAVDPDGKRLYVANSGSNTVsvi 179

                          170       180       190
                   ....*....|....*....|....*....|....*..
gi 2462497869  247 -EVMNT-DGTGRRVLVEDKIPHIFGFTLLGDYVYWTD 281
Cdd:COG3391    180 vSVIDTaTGKVVATIPVGGGPVGVAVSPDGRRLYVAN 216
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 492-532 9.05e-07

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 46.77  E-value: 9.05e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 2462497869  492 GFMYWTEWGGKPKIDRAAMDGSER-TTLVPNVGRANGLTIDY 532
Cdd:pfam00058    1 GRLYWTDSSLRASISSADLNGSDRkTLFTDDLQHPNAIAVDP 42
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 388-426 2.11e-06

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 45.67  E-value: 2.11e-06
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 2462497869   388 IPLTGVKEASALDFDVTDNRIYWTDISLKTISRAFMNGS 426
Cdd:smart00135    3 LLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGT 41
YvrE COG3386
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase ...
 99-290 4.33e-06

Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


Pssm-ID: 442613 [Multi-domain]  Cd Length: 266  Bit Score: 49.89  E-value: 4.33e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462497869   99 YDPvEGYIYWTDDEVRAIRRSFIDGSGSQFVVTAQiAHPDGIAVD-----WVARN---LYWTDTGTDRIEVtrlngtmrk 170
Cdd:COG3386     15 WDP-DGRLYWVDIPGGRIHRYDPDGGAVEVFAEPS-GRPNGLAFDpdgrlLVADHgrgLVRFDPADGEVTV--------- 83

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462497869  171 ilISEDLEEPRA----IVLDPMvGYMYWTDwgeiPKIERAA-----LDGSDRVVLVNTSLGWPNGLALDYDEGKIYWGDA 241
Cdd:COG3386     84 --LADEYGKPLNrpndGVVDPD-GRLYFTD----MGEYLPTgalyrVDPDGSLRVLADGLTFPNGIAFSPDGRTLYVADT 156

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 2462497869  242 KTDKIEVMNTDGTG----RRVLVEDKIPHIF--GFTLLGD-YVYWTDWQRRSIERV 290
Cdd:COG3386    157 GAGRIYRFDLDADGtlgnRRVFADLPDGPGGpdGLAVDADgNLWVALWGGGGVVRF 212
NHL_PKND_like cd14952
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ...
 431-545 1.11e-05

NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271322 [Multi-domain]  Cd Length: 247  Bit Score: 48.36  E-value: 1.11e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462497869  431 VVEF-GLDYPEGMAVDWLGkNLYWADTGTNRieVSKLD-GQHRQ-VLVWKDLDSPRALALDPAeGFMYWTEWGGKPKIDR 507
Cdd:cd14952      3 VLPFtGLDGPGGVAVDAAG-NVYVADSGNNR--VLKLAaGSTTQtVLPFTGLYQPQGVAVDAA-GTVYVTDFGNNRVLKL 78

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 2462497869  508 AAmdGSERTTLVP--NVGRANGLTIDyAKRRLYWTDLDTN 545
Cdd:cd14952     79 AA--GSTTQTVLPftGLNDPTGVAVD-AAGNVYVADTGNN 115
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 94-246 1.14e-05

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 48.47  E-value: 1.14e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462497869   94 AIAIDYDpveGYIYWTDDEVRAIRR-----SFIDGSGSQFVVTAQIAHPDGIAVDwVARNLYWTDTGTDRIEVTRLNGTm 168
Cdd:cd05819    153 GVAVDSD---GNIYVADTGNHRIQVfdpdgNFLTTFGSTGTGPGQFNYPTGIAVD-SDGNIYVADSGNNRVQVFDPDGA- 227

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2462497869  169 rkilisedleepraivldpmvgymYWTDWGEipkieraaldgsdrVVLVNTSLGWPNGLALDyDEGKIYWGDAKTDKI 246
Cdd:cd05819    228 ------------------------GFGGNGN--------------FLGSDGQFNRPSGLAVD-SDGNLYVADTGNNRI 266
NHL_PKND_like cd14952
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ...
 435-545 1.58e-05

NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271322 [Multi-domain]  Cd Length: 247  Bit Score: 47.97  E-value: 1.58e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462497869  435 GLDYPEGMAVDWLGkNLYWADTGTNRieVSKLDGQH--RQVLVWKDLDSPRALALDPAeGFMYWTEWGGKpKIDRAAMDG 512
Cdd:cd14952     92 GLNDPTGVAVDAAG-NVYVADTGNNR--VLKLAAGSntQTVLPFTGLSNPDGVAVDGA-GNVYVTDTGNN-RVLKLAAGS 166

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 2462497869  513 SERTTLvPNVGRA--NGLTIDyAKRRLYWTDLDTN 545
Cdd:cd14952    167 TTQTVL-PFTGLNspSGVAVD-TAGNVYVTDHGNN 199
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 450-489 2.84e-05

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 42.53  E-value: 2.84e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 2462497869  450 NLYWADTGT-NRIEVSKLDGQHRQVLVWKDLDSPRALALDP 489
Cdd:pfam00058    2 RLYWTDSSLrASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
NHL_like_3 cd14956
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 93-254 4.65e-05

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271326 [Multi-domain]  Cd Length: 274  Bit Score: 46.89  E-value: 4.65e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462497869   93 HAIAIDYDpveGYIYWTDD----------EVRAIRRSFIDGSGSQfvvtaQIAHPDGIAVDwVARNLYWTDTGTDRIEVT 162
Cdd:cd14956     16 RGIAVDAD---DNVYVADArngriqvfdkDGTFLRRFGTTGDGPG-----QFGRPRGLAVD-KDGWLYVADYWGDRIQVF 86

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462497869  163 RLNGTMRKILISE-----DLEEPRAIVLDPMvGYMYWTDWGEiPKIERAALDGSdrvvLVNT---------SLGWPNGLA 228
Cdd:cd14956     87 TLTGELQTIGGSSgsgpgQFNAPRGVAVDAD-GNLYVADFGN-QRIQKFDPDGS----FLRQwggtgiepgSFNYPRGVA 160

                          170       180
                   ....*....|....*....|....*.
gi 2462497869  229 LDyDEGKIYWGDAKTDKIEVMNTDGT 254
Cdd:cd14956    161 VD-PDGTLYVADTYNDRIQVFDNDGA 185
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 559-598 5.24e-05

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 41.82  E-value: 5.24e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 2462497869   559 VIADDLPHPFGLT--QYQDYIYWTDWSRRSIERANKTsGQNR 598
Cdd:smart00135    3 LLSSGLGHPNGLAvdWIEGRLYWTDWGLDVIEVANLD-GTNR 43
YvrE COG3386
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase ...
 405-589 1.11e-04

Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


Pssm-ID: 442613 [Multi-domain]  Cd Length: 266  Bit Score: 45.65  E-value: 1.11e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462497869  405 DNRIYWTDISLKTISRAFMNGSALEHVVEFGlDYPEGMAVDWLGkNLYWADTGtNRIEVSKLDGQHRQVLV---WKDLDS 481
Cdd:COG3386     18 DGRLYWVDIPGGRIHRYDPDGGAVEVFAEPS-GRPNGLAFDPDG-RLLVADHG-RGLVRFDPADGEVTVLAdeyGKPLNR 94

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462497869  482 PRALALDPAeGFMYWT---EWGGKPKIDRAAMDGsERTTLVPNVGRANGLTIDYAKRRLYWTDLDTNLI-----ESSNML 553
Cdd:COG3386     95 PNDGVVDPD-GRLYFTdmgEYLPTGALYRVDPDG-SLRVLADGLTFPNGIAFSPDGRTLYVADTGAGRIyrfdlDADGTL 172

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|
gi 2462497869  554 GlNREVIADDLPHPF---GLTQYQD-YIYWTDWSRRSIER 589
Cdd:COG3386    173 G-NRRVFADLPDGPGgpdGLAVDADgNLWVALWGGGGVVR 211
DUF5050 pfam16472
Domain of unknown function (DUF5050);
105-281 1.33e-04

Domain of unknown function (DUF5050);


Pssm-ID: 465128 [Multi-domain]  Cd Length: 282  Bit Score: 45.31  E-value: 1.33e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462497869  105 YIYWTDDEVRAIRRSFIDGSGSQFVVTAQIAHPDgIAVDWVarnlYWTDTGTD-RIEVTRLNGTMRKILISEDLEEPraI 183
Cdd:pfam16472  111 YQHYDNSDGGTLYKIKIDGKEKTKLSDEPISPAS-VSDGWI----YYSGTSDDhYIYKLNTDGDSISKLYDGNSYMP--N 183

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462497869  184 VLDpmvGYMYWTDWGEIPKIERAALDGSDRVVLVNTSLGWPNglaldYDEGKIYWGDAKTD-KIEVMNTDGTGRRVLVED 262
Cdd:pfam16472  184 VNG---DYIYYIDLSNNYALYRMNLSGGEKEVLTDDRVDNYN-----VYGNWIYYQNNGDDnKLYRINTDGSNKEKLAEG 255

                          170
                   ....*....|....*....
gi 2462497869  263 KIPHIfgfTLLGDYVYWTD 281
Cdd:pfam16472  256 NYTNI---NITSDYIYFTD 271
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 406-446 1.48e-04

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 40.22  E-value: 1.48e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 2462497869  406 NRIYWTDISLK-TISRAFMNGSALEHVVEFGLDYPEGMAVDW 446
Cdd:pfam00058    1 GRLYWTDSSLRaSISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
NHL_PKND_like cd14952
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ...
 134-259 1.66e-04

NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271322 [Multi-domain]  Cd Length: 247  Bit Score: 44.89  E-value: 1.66e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462497869  134 IAHPDGIAVDwVARNLYWTDTGTDRIEVTRLNGTMRKILISEDLEEPRAIVLDPmVGYMYWTDWGEIPKIERAAlDGSDR 213
Cdd:cd14952      9 LDGPGGVAVD-AAGNVYVADSGNNRVLKLAAGSTTQTVLPFTGLYQPQGVAVDA-AGTVYVTDFGNNRVLKLAA-GSTTQ 85

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*.
gi 2462497869  214 VVLVNTSLGWPNGLALDyDEGKIYwgdaktdkieVmnTDGTGRRVL 259
Cdd:cd14952     86 TVLPFTGLNDPTGVAVD-AAGNVY----------V--ADTGNNRVL 118
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 690-730 1.77e-04

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 40.28  E-value: 1.77e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 2462497869   690 ILPIHSLRNVRAIDYDPLDKQLYWIDSRQNMIRKAQEDGSQ 730
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTN 42
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 257-290 1.92e-04

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 40.28  E-value: 1.92e-04
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 2462497869   257 RVLVEDKIPHIFGFTL--LGDYVYWTDWQRRSIERV 290
Cdd:smart00135    1 RTLLSSGLGHPNGLAVdwIEGRLYWTDWGLDVIEVA 36
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 104-144 2.51e-04

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 39.84  E-value: 2.51e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 2462497869  104 GYIYWTDDEVRA-IRRSFIDGSGSQFVVTAQIAHPDGIAVDW 144
Cdd:pfam00058    1 GRLYWTDSSLRAsISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
NHL_like_2 cd14957
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...
 93-254 2.66e-04

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271327 [Multi-domain]  Cd Length: 280  Bit Score: 44.56  E-value: 2.66e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462497869   93 HAIAIDYDpveGYIYWTDDEVRAIR-----RSFIDGSGSQFVVTAQIAHPDGIAVDwVARNLYWTDTGTDRIEV-TRLNG 166
Cdd:cd14957     21 RGIAVDSA---GNIYVADTGNNRIQvftssGVYSYSIGSGGTGSGQFNSPYGIAVD-SNGNIYVADTDNNRIQVfNSSGV 96

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462497869  167 TMRKI----LISEDLEEPRAIVLDPMvGYMYWTDwgeipkieraalDGSDRVVLVNTS----------------LGWPNG 226
Cdd:cd14957     97 YQYSIgtggSGDGQFNGPYGIAVDSN-GNIYVAD------------TGNHRIQVFTSSgtfsysigsggtgpgqFNGPQG 163

                          170       180
                   ....*....|....*....|....*...
gi 2462497869  227 LALDYDeGKIYWGDAKTDKIEVMNTDGT 254
Cdd:cd14957    164 IAVDSD-GNIYVADTGNHRIQVFTSSGT 190
NHL_like_3 cd14956
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 437-517 4.38e-04

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271326 [Multi-domain]  Cd Length: 274  Bit Score: 43.81  E-value: 4.38e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462497869  437 DYPEGMAVDwLGKNLYWADTGTNRIEVSKLDGQH-RQvlVWK------DLDSPRALALDPAEGFMYWTEWGGkpKIDRAA 509
Cdd:cd14956     13 KDPRGIAVD-ADDNVYVADARNGRIQVFDKDGTFlRR--FGTtgdgpgQFGRPRGLAVDKDGWLYVADYWGD--RIQVFT 87


                   ....*...
gi 2462497869  510 MDGSERTT 517
Cdd:cd14956     88 LTGELQTI 95
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
700-807 5.20e-04

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 43.14  E-value: 5.20e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462497869  700 RAIDYDPLDKQLYWIDSRQNMIRKAqeDGSQGftVVVSSVPsqnLEIQPYDLSIDIYSRYIYWTCEATN---VInVTRLD 776
Cdd:COG3391    113 RGLAVDPDGGRLYVADSGNGRVSVI--DTATG--KVVATIP---VGAGPHGIAVDPDGKRLYVANSGSNtvsVI-VSVID 184

                           90       100       110
                   ....*....|....*....|....*....|...
gi 2462497869  777 GRSvGVVLK--GEQDRPRAVVVNPEKGYMYFTN 807
Cdd:COG3391    185 TAT-GKVVAtiPVGGGPVGVAVSPDGRRLYVAN 216
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 801-842 6.22e-04

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 38.68  E-value: 6.22e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 2462497869  801 GYMYFTNLQERsPKIERAALDGTEREVLFFSGLSKPIALALD 842
Cdd:pfam00058    1 GRLYWTDSSLR-ASISSADLNGSDRKTLFTDDLQHPNAIAVD 41
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 133-259 6.73e-04

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 43.08  E-value: 6.73e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462497869  133 QIAHPDGIAVDwVARNLYWTDTGTDRIEVTRLNGTmRKILISED------LEEPRAIVLDPMvGYMYWTDWG--EIPKIe 204
Cdd:cd05819      6 ELNNPQGIAVD-SSGNIYVADTGNNRIQVFDPDGN-FITSFGSFgsgdgqFNEPAGVAVDSD-GNLYVADTGnhRIQKF- 81

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462497869  205 raalDGSDRVVLVNTSLGW-------PNGLALDyDEGKIYWGDAKTDKIEVMNTDGTGRRVL 259
Cdd:cd05819     82 ----DPDGNFLASFGGSGDgdgefngPRGIAVD-SSGNIYVADTGNHRIQKFDPDGEFLTTF 138
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 846-886 7.87e-04

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 38.29  E-value: 7.87e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 2462497869  846 GKLFWADSDLR-RIESSDLSGANRIVLEDSNILQPVGLTVFE 886
Cdd:pfam00058    1 GRLYWTDSSLRaSISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 403-547 7.97e-04

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 43.08  E-value: 7.97e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462497869  403 VTD---NRIYWTDISLKTISRAfmnGSALEHVVEFglDYPEGMAVDWLGkNLYWADTGTNRIEVSKLDGQhrQVLVWKD- 478
Cdd:cd05819    117 VADtgnHRIQKFDPDGEFLTTF---GSGGSGPGQF--NGPTGVAVDSDG-NIYVADTGNHRIQVFDPDGN--FLTTFGSt 188

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462497869  479 ------LDSPRALALDPaEGFMYWTEWGGKpKIDRAAMDGSERTTLVPNVGRAN------GLTIDyAKRRLYWTDLDTNL 546
Cdd:cd05819    189 gtgpgqFNYPTGIAVDS-DGNIYVADSGNN-RVQVFDPDGAGFGGNGNFLGSDGqfnrpsGLAVD-SDGNLYVADTGNNR 265


                   .
gi 2462497869  547 I 547
Cdd:cd05819    266 I 266
NHL_like_3 cd14956
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 435-548 8.39e-04

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271326 [Multi-domain]  Cd Length: 274  Bit Score: 43.04  E-value: 8.39e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462497869  435 GLDYPEGMAVDWLGkNLYWADTGTNRIEVSKLDGqhRQVLVW-------KDLDSPRALALDPAeGFMYWTEWGGKpKIDR 507
Cdd:cd14956    152 SFNYPRGVAVDPDG-TLYVADTYNDRIQVFDNDG--AFLRKWggrgtgpGQFNYPYGIAIDPD-GNVFVADFGNN-RIQK 226

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*...
gi 2462497869  508 AAMDGSERTTlVPNVGRANG-------LTIDyAKRRLYWTDLDTNLIE 548
Cdd:cd14956    227 FTADGTFLTS-WGSPGTGPGqfknpwgVVVD-ADGTVYVADSNNNRVQ 272
SGL pfam08450
SMP-30/Gluconolactonase/LRE-like region; This family describes a region that is found in ...
 99-261 1.14e-03

SMP-30/Gluconolactonase/LRE-like region; This family describes a region that is found in proteins expressed by a variety of eukaryotic and prokaryotic species. These proteins include various enzymes, such as senescence marker protein 30 (SMP-30), gluconolactonase and luciferin-regenerating enzyme (LRE). SMP-30 is known to hydrolyse diisopropyl phosphorofluoridate in the liver, and has been noted as having sequence similarity, in the region described in this family, with PON1 and LRE.


Pssm-ID: 462480 [Multi-domain]  Cd Length: 246  Bit Score: 42.25  E-value: 1.14e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462497869   99 YDPVEGYIYWTDDEVRAIRR-SFIDGSGSQFVVTAQIA----HPDGIAVDWVARNLYWTDTGTdrievtrlnGTMRKILI 173
Cdd:pfam08450    7 WDEEEGALYWVDILGGRIHRlDPATGKETVWDTPGPVGaiapRDDGGLIVALKDGVALLDLAT---------GELTPLAD 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462497869  174 SEDLEEPRAI----VLDP----MVGYMywtDWGEIPKIERAAL---DGSDRVVLVNTSLGWPNGLALDYDEGKIYWGDAK 242
Cdd:pfam08450   78 PEDDDWPLNRfndgKVDPdgrfWFGTM---GDDEAPGGDPGALyrlDPDGKLTRVLDGLTISNGLAWSPDGRTLYFADSP 154

                          170       180
                   ....*....|....*....|....
gi 2462497869  243 TDKIEVMNTDGTG-----RRVLVE 261
Cdd:pfam08450  155 ARKIWAYDYDLDGglisnRRVFAD 178
NHL_like_5 cd14963
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 399-488 1.56e-03

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271333 [Multi-domain]  Cd Length: 268  Bit Score: 41.89  E-value: 1.56e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462497869  399 LDFDVTDNRIYWTDISLKTIsRAFMNGSalEHVVEFG--------LDYPEGMAVDWLGkNLYWADTGTNRIEVSKLDGQH 470
Cdd:cd14963     13 MGVAVSDGRIYVADTNNHRV-QVFDYEG--KFKKSFGgpgtgpgeFKYPYGIAVDSDG-NIYVADLYNGRIQVFDPDGKF 88

                           90       100
                   ....*....|....*....|..
gi 2462497869  471 RQVLVWKD----LDSPRALALD 488
Cdd:cd14963     89 LKYFPEKKdrvkLISPAGLAID 110
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 397-489 2.03e-03

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 41.54  E-value: 2.03e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462497869  397 SALDFDvTDNRIYWTDISLKTISRAFMNGSALEHVVEFG-----LDYPEGMAVDWLGkNLYWADTGTNRIEVSKLDGQHr 471
Cdd:cd05819     58 AGVAVD-SDGNLYVADTGNHRIQKFDPDGNFLASFGGSGdgdgeFNGPRGIAVDSSG-NIYVADTGNHRIQKFDPDGEF- 134

                           90       100
                   ....*....|....*....|....*
gi 2462497869  472 qVLVWK-------DLDSPRALALDP 489
Cdd:cd05819    135 -LTTFGsggsgpgQFNGPTGVAVDS 158
NHL_PKND_like cd14952
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ...
 123-246 2.22e-03

NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271322 [Multi-domain]  Cd Length: 247  Bit Score: 41.42  E-value: 2.22e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462497869  123 GSGSQFVVT-AQIAHPDGIAVDwVARNLYWTDTGTDRIEVTRLNGTMRKILISEDLEEPRAIVLDPmVGYMYWTDWGEiP 201
Cdd:cd14952    123 GSNTQTVLPfTGLSNPDGVAVD-GAGNVYVTDTGNNRVLKLAAGSTTQTVLPFTGLNSPSGVAVDT-AGNVYVTDHGN-N 199

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*
gi 2462497869  202 KIERAALDGSDRVVLVNTSLGWPNGLALDyDEGKIYWGDAKTDKI 246
Cdd:cd14952    200 RVLKLAAGSTTPTVLPFTGLNGPLGVAVD-AAGNVYVADRGNDRV 243
NHL_PKND_like cd14952
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ...
 137-259 2.47e-03

NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271322 [Multi-domain]  Cd Length: 247  Bit Score: 41.04  E-value: 2.47e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462497869  137 PDGIAVDwVARNLYWTDTGTDRieVTRLNG--TMRKILISEDLEEPRAIVLDPmVGYMYWTDWGEiPKIERAALDGSDRV 214
Cdd:cd14952     96 PTGVAVD-AAGNVYVADTGNNR--VLKLAAgsNTQTVLPFTGLSNPDGVAVDG-AGNVYVTDTGN-NRVLKLAAGSTTQT 170

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*
gi 2462497869  215 VLVNTSLGWPNGLALDyDEGKIYwgdaktdkieVmnTDGTGRRVL 259
Cdd:cd14952    171 VLPFTGLNSPSGVAVD-TAGNVY----------V--TDHGNNRVL 202
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
71-159 2.58e-03

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 41.16  E-value: 2.58e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462497869   71 LRRISLDTPDFTDIVLQLEDIR-HAIAIDYDpveGYIYWTDDEVRAIRRsfID---GSGSQFVVTAQIAHPDGIAVDwVA 146
Cdd:COG4257    168 IGRIDPDTGTLTEYALPTPGAGpRGLAVDPD---GNLWVADTGSGRIGR--FDpktGTVTEYPLPGGGARPYGVAVD-GD 241

                           90
                   ....*....|...
gi 2462497869  147 RNLYWTDTGTDRI 159
Cdd:COG4257    242 GRVWFAESGANRI 254
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
374-547 2.95e-03

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 41.16  E-value: 2.95e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462497869  374 IRRISLETNN-NNVAIPlTGVKEASALDFDVtDNRIYWTDISLKTISR---AfmNGSALEHVVEFGLDYPEGMAVDWLGk 449
Cdd:COG4257     82 IGRIDPKTGEiTTFALP-GGGSNPHGIAFDP-DGNLWFTDQGGNRIGRldpA--TGEVTEFPLPTGGAGPYGIAVDPDG- 156

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462497869  450 NLYWADTGTNRI-EVSKLDGQHRQVLVWKDLDSPRALALDPaEGFMYWTEWGGKP--KIDRAamDGSERT-TLVPNVGRA 525
Cdd:COG4257    157 NLWVTDFGANAIgRIDPDTGTLTEYALPTPGAGPRGLAVDP-DGNLWVADTGSGRigRFDPK--TGTVTEyPLPGGGARP 233

                          170       180
                   ....*....|....*....|..
gi 2462497869  526 NGLTIDyAKRRLYWTDLDTNLI 547
Cdd:COG4257    234 YGVAVD-GDGRVWFAESGANRI 254
NHL_like_5 cd14963
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 402-489 3.33e-03

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271333 [Multi-domain]  Cd Length: 268  Bit Score: 41.12  E-value: 3.33e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462497869  402 DVTDNRIYWTDISLKTISRAFMNGsalEHVVEFG--------LDYPEGMAVDWLGkNLYWADTGTNRIEVSKLDGQHRQV 473
Cdd:cd14963    108 AIDDGKLYVSDVKKHKVIVFDLEG---KLLLEFGkpgsepgeLSYPNGIAVDEDG-NIYVADSGNGRIQVFDKNGKFIKE 183

                           90       100
                   ....*....|....*....|.
gi 2462497869  474 LVWKDLDS-----PRALALDP 489
Cdd:cd14963    184 LNGSPDGKsgfvnPRGIAVDP 204
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 436-502 4.32e-03

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 40.76  E-value: 4.32e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2462497869  436 LDYPEGMAVDWLGkNLYWADTGTNRIevSKLDGQHRQVLVW-------KDLDSPRALALDPAeGFMYWTEWGGK 502
Cdd:cd05819     54 FNEPAGVAVDSDG-NLYVADTGNHRI--QKFDPDGNFLASFggsgdgdGEFNGPRGIAVDSS-GNIYVADTGNH 123
NHL_TRIM71_like cd14954
NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; ...
 436-489 6.48e-03

NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; The E3 ubiquitin-protein ligase TRIM71 (LIN-41) is a RING-finger domain containing protein that has been associated with a variety of activities. The NHL repeat domain appears responsible for targeting TRIM71 to mRNAs, and TRIM71 appears responsible for translational repression and mRNA decay. Together with BRAT, TRIM71 may be part of a family of mRNA repressors that regulate proliferation and differentiation. TRIM has been shown to negatively regulate stability of Lin28B, which inhibits the pre-let-7 miRNA precursor from maturing by recruiting the terminal uriyltransferase TUT4. This family also contains the Caenorhabditis elegans NHL repeat containing 1 (NHL-1), a RING-finger-containing protein that was shown to interact with E2 ubiquitin conjugating enzymes in two-hybrid screens. Its domain architecture resembles that of the E3 ubiquitin protein ligases TRIM2, TRIM32, and TRIM71. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271324 [Multi-domain]  Cd Length: 285  Bit Score: 40.22  E-value: 6.48e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 2462497869  436 LDYPEGMAVDWLGkNLYWADTGTNRIEVSKLDGQH-----RQVLVWKDLDSPRALALDP 489
Cdd:cd14954    117 FNYPWGVAVDSEG-RIYVSDTRNHRVQVFDSDGQFirkfgFEGAGPGQLDSPRGVAVNP 174
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 747-780 7.04e-03

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 35.66  E-value: 7.04e-03
                            10        20        30
                    ....*....|....*....|....*....|....
gi 2462497869   747 QPYDLSIDIYSRYIYWTCEATNVINVTRLDGRSV 780
Cdd:smart00135   10 HPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 782-825 7.18e-03

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 35.66  E-value: 7.18e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 2462497869   782 VVLKGEQDRPRAVVVNPEKGYMYFTNLqeRSPKIERAALDGTER 825
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDW--GLDVIEVANLDGTNR 43
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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