![](files/infoQ.gif)
spermatogenesis-associated protein 21 isoform X2 [Homo sapiens]
EF-hand domain-containing protein( domain architecture ID 10040236)
EF-hand (EFh) domain-containing protein may be involved in binding intracellular calcium and in calcium signal transduction
List of domain hits
![](files/help.png)
Name | Accession | Description | Interval | E-value | ||||
EFh | cd00051 | EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal ... |
452-511 | 3.98e-10 | ||||
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to the activation or inactivation of target proteins. EF-hands tend to occur in pairs or higher copy numbers. : Pssm-ID: 238008 [Multi-domain] Cd Length: 63 Bit Score: 56.02 E-value: 3.98e-10
|
||||||||
PHA03247 super family | cl33720 | large tegument protein UL36; Provisional |
159-384 | 6.22e-05 | ||||
large tegument protein UL36; Provisional The actual alignment was detected with superfamily member PHA03247: Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 46.47 E-value: 6.22e-05
|
||||||||
Name | Accession | Description | Interval | E-value | ||||
EFh | cd00051 | EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal ... |
452-511 | 3.98e-10 | ||||
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to the activation or inactivation of target proteins. EF-hands tend to occur in pairs or higher copy numbers. Pssm-ID: 238008 [Multi-domain] Cd Length: 63 Bit Score: 56.02 E-value: 3.98e-10
|
||||||||
PTZ00184 | PTZ00184 | calmodulin; Provisional |
449-511 | 4.06e-08 | ||||
calmodulin; Provisional Pssm-ID: 185504 [Multi-domain] Cd Length: 149 Bit Score: 52.84 E-value: 4.06e-08
|
||||||||
Dockerin_1 | pfam00404 | Dockerin type I domain; The dockerin repeat is the binding partner of the cohesin domain ... |
460-510 | 4.38e-05 | ||||
Dockerin type I domain; The dockerin repeat is the binding partner of the cohesin domain pfam00963. The cohesin-dockerin interaction is the crucial interaction for complex formation in the cellulosome. The dockerin repeats, each bearing homology to the EF-hand calcium-binding loop bind calcium. This family contains two copies of the repeat. Pssm-ID: 459805 [Multi-domain] Cd Length: 56 Bit Score: 41.40 E-value: 4.38e-05
|
||||||||
PHA03247 | PHA03247 | large tegument protein UL36; Provisional |
159-384 | 6.22e-05 | ||||
large tegument protein UL36; Provisional Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 46.47 E-value: 6.22e-05
|
||||||||
FRQ1 | COG5126 | Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]; |
448-512 | 6.62e-05 | ||||
Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]; Pssm-ID: 444056 [Multi-domain] Cd Length: 137 Bit Score: 43.24 E-value: 6.62e-05
|
||||||||
EFh | smart00054 | EF-hand, calcium binding motif; EF-hands are calcium-binding motifs that occur at least in ... |
485-511 | 2.36e-03 | ||||
EF-hand, calcium binding motif; EF-hands are calcium-binding motifs that occur at least in pairs. Links between disease states and genes encoding EF-hands, particularly the S100 subclass, are emerging. Each motif consists of a 12 residue loop flanked on either side by a 12 residue alpha-helix. EF-hands undergo a conformational change unpon binding calcium ions. Pssm-ID: 197492 [Multi-domain] Cd Length: 29 Bit Score: 35.82 E-value: 2.36e-03
|
||||||||
Name | Accession | Description | Interval | E-value | |||||
EFh | cd00051 | EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal ... |
452-511 | 3.98e-10 | |||||
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to the activation or inactivation of target proteins. EF-hands tend to occur in pairs or higher copy numbers. Pssm-ID: 238008 [Multi-domain] Cd Length: 63 Bit Score: 56.02 E-value: 3.98e-10
|
|||||||||
PTZ00184 | PTZ00184 | calmodulin; Provisional |
449-511 | 4.06e-08 | |||||
calmodulin; Provisional Pssm-ID: 185504 [Multi-domain] Cd Length: 149 Bit Score: 52.84 E-value: 4.06e-08
|
|||||||||
PTZ00183 | PTZ00183 | centrin; Provisional |
434-511 | 6.53e-07 | |||||
centrin; Provisional Pssm-ID: 185503 [Multi-domain] Cd Length: 158 Bit Score: 49.30 E-value: 6.53e-07
|
|||||||||
PTZ00184 | PTZ00184 | calmodulin; Provisional |
442-510 | 4.24e-06 | |||||
calmodulin; Provisional Pssm-ID: 185504 [Multi-domain] Cd Length: 149 Bit Score: 47.06 E-value: 4.24e-06
|
|||||||||
Dockerin_1 | pfam00404 | Dockerin type I domain; The dockerin repeat is the binding partner of the cohesin domain ... |
460-510 | 4.38e-05 | |||||
Dockerin type I domain; The dockerin repeat is the binding partner of the cohesin domain pfam00963. The cohesin-dockerin interaction is the crucial interaction for complex formation in the cellulosome. The dockerin repeats, each bearing homology to the EF-hand calcium-binding loop bind calcium. This family contains two copies of the repeat. Pssm-ID: 459805 [Multi-domain] Cd Length: 56 Bit Score: 41.40 E-value: 4.38e-05
|
|||||||||
PHA03247 | PHA03247 | large tegument protein UL36; Provisional |
159-384 | 6.22e-05 | |||||
large tegument protein UL36; Provisional Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 46.47 E-value: 6.22e-05
|
|||||||||
FRQ1 | COG5126 | Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]; |
448-512 | 6.62e-05 | |||||
Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]; Pssm-ID: 444056 [Multi-domain] Cd Length: 137 Bit Score: 43.24 E-value: 6.62e-05
|
|||||||||
EF-hand_7 | pfam13499 | EF-hand domain pair; |
449-511 | 1.15e-04 | |||||
EF-hand domain pair; Pssm-ID: 463900 [Multi-domain] Cd Length: 67 Bit Score: 40.70 E-value: 1.15e-04
|
|||||||||
PHA03247 | PHA03247 | large tegument protein UL36; Provisional |
151-426 | 5.42e-04 | |||||
large tegument protein UL36; Provisional Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 43.39 E-value: 5.42e-04
|
|||||||||
EF-hand_8 | pfam13833 | EF-hand domain pair; |
463-512 | 2.24e-03 | |||||
EF-hand domain pair; Pssm-ID: 404678 [Multi-domain] Cd Length: 54 Bit Score: 36.52 E-value: 2.24e-03
|
|||||||||
EFh | smart00054 | EF-hand, calcium binding motif; EF-hands are calcium-binding motifs that occur at least in ... |
485-511 | 2.36e-03 | |||||
EF-hand, calcium binding motif; EF-hands are calcium-binding motifs that occur at least in pairs. Links between disease states and genes encoding EF-hands, particularly the S100 subclass, are emerging. Each motif consists of a 12 residue loop flanked on either side by a 12 residue alpha-helix. EF-hands undergo a conformational change unpon binding calcium ions. Pssm-ID: 197492 [Multi-domain] Cd Length: 29 Bit Score: 35.82 E-value: 2.36e-03
|
|||||||||
PHA03247 | PHA03247 | large tegument protein UL36; Provisional |
205-397 | 2.41e-03 | |||||
large tegument protein UL36; Provisional Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 41.46 E-value: 2.41e-03
|
|||||||||
PTZ00183 | PTZ00183 | centrin; Provisional |
456-513 | 3.14e-03 | |||||
centrin; Provisional Pssm-ID: 185503 [Multi-domain] Cd Length: 158 Bit Score: 38.90 E-value: 3.14e-03
|
|||||||||
PRK05641 | PRK05641 | putative acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated |
305-393 | 3.20e-03 | |||||
putative acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated Pssm-ID: 235540 [Multi-domain] Cd Length: 153 Bit Score: 38.69 E-value: 3.20e-03
|
|||||||||
EFh_calglandulin_like | cd16252 | EF-hand, calcium binding motif, found in uncharacterized calglandulin-like proteins; The ... |
435-511 | 3.45e-03 | |||||
EF-hand, calcium binding motif, found in uncharacterized calglandulin-like proteins; The family corresponds to a group of uncharacterized calglandulin-like proteins. Although their biological function remain unclear, they show high sequence similarity with human calglandulin-like protein GAGLP, which is an ortholog of calglandulin from the venom glands of Bothrops insularis snake. Both GAGLP and calglandulin are putative Ca2+-binding proteins with four EF-hand motifs. However, members in this family contain only three EF-hand motifs. In this point, they may belong to the parvalbumin-like EF-hand family, which is characterized by the presence of three consecutive EF-hand motifs (helix-loop-helix). Pssm-ID: 319995 [Multi-domain] Cd Length: 106 Bit Score: 37.51 E-value: 3.45e-03
|
|||||||||
EF-hand_1 | pfam00036 | EF hand; The EF-hands can be divided into two classes: signalling proteins and buffering ... |
486-513 | 4.82e-03 | |||||
EF hand; The EF-hands can be divided into two classes: signalling proteins and buffering/transport proteins. The first group is the largest and includes the most well-known members of the family such as calmodulin, troponin C and S100B. These proteins typically undergo a calcium-dependent conformational change which opens a target binding site. The latter group is represented by calbindin D9k and do not undergo calcium dependent conformational changes. Pssm-ID: 425435 [Multi-domain] Cd Length: 29 Bit Score: 35.07 E-value: 4.82e-03
|
|||||||||
PRK14954 | PRK14954 | DNA polymerase III subunits gamma and tau; Provisional |
330-404 | 9.69e-03 | |||||
DNA polymerase III subunits gamma and tau; Provisional Pssm-ID: 184918 [Multi-domain] Cd Length: 620 Bit Score: 39.16 E-value: 9.69e-03
|
|||||||||
Blast search parameters | ||||
|