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Conserved domains on  [gi|2462507031|ref|XP_054191543|]
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E3 ubiquitin-protein ligase UBR4 isoform X11 [Homo sapiens]

Protein Classification

E3 ubiquitin-protein ligase UBR4 family protein( domain architecture ID 18340960)

E3 ubiquitin-protein ligase UBR4 family protein similar to mammalian E3 ubiquitin-protein ligase UBR4 that is a a component of the N-end rule pathway; it recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
E3_UBR4_N super family cl44844
E3 ubiquitin-protein ligase UBR4 N-terminal; This entry represents the N-terminal of E3 ...
69-1650 0e+00

E3 ubiquitin-protein ligase UBR4 N-terminal; This entry represents the N-terminal of E3 ubiquitin-protein ligases UBR4 (POE or PUSHOVER in Drosophila), which are components of the N-rule pathway, identified as noncanonical N-recognins implicated in bulk lysosomal degradation and autophagy. These are extraordinarily large proteins that recognize and bind to proteins with N-terminal destabilising residues according to the N-end rule leading them to their ubiquitination and degradation. These proteins share a UBR box (pfam02207) with others E3-ligases UBR box proteins but UBR4 lacks the ubiquitylation domain, suggesting that it may interact with other catalytic proteins.


The actual alignment was detected with superfamily member pfam19423:

Pssm-ID: 466074  Cd Length: 1598  Bit Score: 2597.99  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462507031   69 QYEPFYSSFVALSTHYITTVCSLIPRNQLQSVAAACKVLIEFSLLRLENPDEACAVSQKHLILLIKGLCTGCSRLDRTEI 148
Cdd:pfam19423    1 QYEPFYSSFVALASHYISTVAGSVPRNQLGSVSSACRVLLKFLLLRLQNPDDACAVSQKHLMMLIKALCTGCSRLDKADV 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462507031  149 ITFTAMMKSAKLPQTVKTLSDvEDQKELASPVSPELRQKEVQMNFLNQLTSVFNPRTVAS---QPISTQTLVEGENDEQS 225
Cdd:pfam19423   81 ITFTAMLRSAKAPQTIKELDT-EDQKELASEVQPELRQKETGMDIFDQLTSVFNEVSVSSphkAEPVVDPLAEGDTDHQR 159
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462507031  226 StdQASAIKTKNVFIAQNVASLQELGGSEKLLRVCLNLPYFLRYINRFQDAVLANSFfIMPATVADATAVRNGFHSLVID 305
Cdd:pfam19423  160 H--QASSEKLKNAFGKRNVSSLLQLDGSEILVDVCLNLTFLLRYSQRFKDAVAGNSF-IMPATLADALTVRNSYQSLLID 236
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462507031  306 VTMALDTLSLPVLEPLNPSRLQDVTVLSLSCLYAGVSVATCMAILHVGSAQQVRtgSTSSKEDDYESDAATIVQKCLEIY 385
Cdd:pfam19423  237 ISIAWRAFSLPVLEPLTPKRLEKITVITLSCLYASVSVAMCNAVLALTSTQPAK--STSSKDEEIDNYGATIVQKSLEIF 314
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462507031  386 DMIGQAISSSRRAGGEHYQNFQLLGAWCLLNSLFLILNLSPTALADKGKEKDPLAALRVRDILSRTKEGVGSPKLGPGKG 465
Cdd:pfam19423  315 NMISQAISNSTRAGGNHYQNLNLLGAWLLLNGLQLILNLTPTTLLERGKEKDPLAALRPSDIGTKTKEGQGSPKLGPKSG 394
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462507031  466 HQGFGVLSVILANHAIKLLTSLFQDLQVEALHK---GWETDGPPAALSIMAQSTSIQRIQRLIDSVPLMNLLLTLLSTSY 542
Cdd:pfam19423  395 HQGFGVLSVILANKAVQLLTELLQDLQVEGLHPdlgGWAPDGPPAVLTIMAQSTAIQRVQKLIDSVPLTDLLFTLVSTSF 474
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462507031  543 RKACVLQRQRKGSMSSDASASTDS--NTYYEDDFSSTEEDSSQDDDSEPILGQWFEETISPSKEKAAPPPPPPPPPLESS 620
Cdd:pfam19423  475 RKASVLQRLKQGSESSEASSSSASdsNTFYEDDFSSTEESSDEDEDSEPILGQWFEETISPSKTKVAPPPPPPPPPLEDS 554
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462507031  621 PRVKSPSKQAPGEKGNILASRKDPELFLGLASNILNFITSSMLNSRNNFIRNYLSVSLSEHHMATLASIIKEVDKDGLKG 700
Cdd:pfam19423  555 PREKSPSKQSPGDSGNILPDKKDPEGFVGLASDILNFLSQSFLNSRDNELQKYLSSSLNEDHMATLASLIKELDRDCIKG 634
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462507031  701 SSDEE---FAAALYHFNHSLVTSDLQSPNLQNTLLQQLGVAPFSEGPWPLYIHPQSLSVLSRLLLIWQHK---ASAQGDP 774
Cdd:pfam19423  635 SSDKVfdgLSIALAKFNHNLISSGLLSPNLQDTLLQQLGVAPFAVGPWPLTIHPRTLAVLAELLLLKQQKereAKLQKSQ 714
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462507031  775 DVPECLKVWDRFLSTMKQNAL-QGVVPSETeDLNVEHLQMLLLIFHNFTETGRRAILSLFVQIIQE-LSVNMDAQMRFVP 852
Cdd:pfam19423  715 SEAAVIKVWVRFITTLKSNIIlDGQVDSED-DINVEHLQLLLFLFHSLPLMGKKSLLLQLAQNIIAiNEMDIEKLENMVP 793
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462507031  853 LILARLLLIFDYLLHQYSKAPVYLFEQVQHNLLSPPFGWASGSQDSNSRRAttPLYHGFKEVEENWSKHFS----SDAVP 928
Cdd:pfam19423  794 LPLTRLLLVFEYLLHYFYDPPPELFEQVRWNLFTPPAQTASGEQDGLSRRQ--TLFFGCREVEENYRRHLTaqeiSDAVQ 871
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462507031  929 HPRFYCVLSPEASEDDLNRLDSVACDVLFSKL--VKYDELYAALTALLAAGSQLDTVRRKENKNVTALEACALQYYFLIL 1006
Cdd:pfam19423  872 QPRFYNLGPPEVNEQDTPKVDGLACSFLLSSAdvVKYNELYDACISLLMAGSQCDTVRRKENKKLSILDACALHYHFLVL 951
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462507031 1007 WRILGILPPSKTYINQLSMNSPEMSECDILHTLRWSSRLRISSYVNWIKDHLIKQGMKAEHASSLLELASTtKCSSVKYD 1086
Cdd:pfam19423  952 WRLLACLPPSIQYLRMLESGELDMSNSDILHTLRWSSRLRHKVFVNWMKDHLVKQGLTTQQAESLLTSANK-KCNNVKYD 1030
                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462507031 1087 VEIVEEYFARQISSFCSIDCTTILQLHEIPSLQSIYTLDAAISKVQVSLDEHFSKMAAETDPHKSSEITKNLLPATLQLI 1166
Cdd:pfam19423 1031 VRLAEEFLARQISSFLSIDPKEILPLTDLPGLQSVYTLDAVIAKVQVSLEETFTKAMADIDPHKAMEIAKNLLPATLQLI 1110
                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462507031 1167 DTYASFTRAYLLQNFNEEGTTE-KPSKEKLQGFAAVLAIGSSRCKANT-LGPTLVQNLPSSVQTVCESWNNINTNEFPNI 1244
Cdd:pfam19423 1111 ETYTVFVRSCILHQLKEEGDTEmVLTPEKLDGYGAVLSIGSTRPSKVSvLGADIMQTLPRPVQLACEKWNSITTNEFPSI 1190
                         1210      1220      1230      1240      1250      1260      1270      1280
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462507031 1245 GSWRNAFANDTIPSESYISAVQAAHLGTLCSQSLPLAASLKHTLLSLVRLTGDLIVWSDEMNPPQVIRTLLPLLLESSTE 1324
Cdd:pfam19423 1191 GAWRNAFANDIIPSESYIDAVQAAHLGTLSEQSFPIAASLKHTLLSLVRFTSDLIVWCPETNPKEMIRVMFPLLLDASTA 1270
                         1290      1300      1310      1320      1330      1340      1350      1360
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462507031 1325 SVAEISSNSLERILGPAESDEFLARVYEKLITGCYNILANHADPNSGLDESILEECLQYLEKQLESSQARKAMEEFFSDS 1404
Cdd:pfam19423 1271 YVADMSSQSLERFLGPVDSDEFMERTYEYLFSVCYDLCANHSEPQSGLDESVLEECLKFMENHIEKSQERKAFEEFFSES 1350
                         1370      1380      1390      1400      1410      1420      1430      1440
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462507031 1405 GELVQIMMATANENLSAKFCNRVLKFFTKLFQLTEKSPNPSLLHLCGSLAQLACVEPVRLQAWLTRMtTSPPKDSDQLDV 1484
Cdd:pfam19423 1351 GDLVQLMLSTAKENLSAKFCNRVLRFFTKLFQLTEKSPDKSYEVLCGSLSQLACVDPSRLQNWLTKM-IAPSEDSEQLNT 1429
                         1450      1460      1470      1480      1490      1500      1510      1520
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462507031 1485 IQENRQLLQLLTTYIVRENSQVGEGVCAVLLGTLTPMATEMLANGDG--TGFPELMVVMATLASAGQGAGHLQLHNAAVD 1562
Cdd:pfam19423 1430 LQENRQLLRTLTTHIVKENSQVSEKVCLVLLCTLIPMGTILLAGGDGeiTGFPELMMVMHTLAGAGQGAGHLQLFQAATD 1509
                         1530      1540      1550      1560      1570      1580      1590      1600
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462507031 1563 WLSRCKKYLSQKNVVEKLNANVMHGKHVMILECTCHIMSYLADVTNALSQSNGQGPSHLSVDGEERAIEV-DSDWVEELA 1641
Cdd:pfam19423 1510 WLDRCKKYLNKKEVLEKMTSNNGHGKHPAVLDCLCCILSYLGEILGALKQSSGQGGSSLPVDGDEAAPEVgDSDWVEDLT 1589

                   ....*....
gi 2462507031 1642 VEEEDSQAE 1650
Cdd:pfam19423 1590 VEEDDSQGE 1598
E3_UbLigase_R4 pfam13764
E3 ubiquitin-protein ligase UBR4; This is a family of E3 ubiquitin ligase enzymes.
4396-5192 0e+00

E3 ubiquitin-protein ligase UBR4; This is a family of E3 ubiquitin ligase enzymes.


:

Pssm-ID: 433459  Cd Length: 807  Bit Score: 1339.21  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462507031 4396 MPGNPYSSNEPGIGPLMRDIKNKICQDCDLVALLEDDSGMELLVNNKIISLDLPVAEVYKKVWCTT-NEGEPMRIVYRMR 4474
Cdd:pfam13764    1 MLGNPYSSNEPGLGPLMRDVKNKICQDCELVALLEDDNGMELLVNNKIISLDLPVKDVYEKVWKKEnNEGEPMRVVYRMR 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462507031 4475 GLLGDATEEFIESLDSTTDEEEDEEEVYKMAGVMAQCGGLECMLNRLAGIRDFKQGRHLLTVLLKLFSYCVKVKVNRQQL 4554
Cdd:pfam13764   81 GLDGDATEEFIEELEDDSEEEVDPEEEYKMANVMAECGGLEVMLSRLATIRDLSSGRELLQVLLKLLSYCVKIKVNRQAL 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462507031 4555 vkLEMNTLNVMLGTLNLALVAEQEskdsgGAAVAEQVLSIMEIILDESNAEPLSEDKGNLLLT------GDKDQLVMLLD 4628
Cdd:pfam13764  161 --LKLGALGVLLETLKLAFSAEQE-----GPEIAEQLLLIMESILSEANESDLEGSTQSSLTThekrgeGAKEQVLMLLD 233
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462507031 4629 QINSTFVRSNPSVLQGLLRIIPYLSFGEVEKMQILVERFKPYCNFDKYDE--DHSGDDKVFLDCFCKIAAGIKNNSNGHQ 4706
Cdd:pfam13764  234 RLNSPFVRKNQSVLQALTRIIPFLTYGEEEKMAALVDHFKPYLNFEKFDElqSHTAEQQFHLECFCRIAEGIENNSNGNR 313
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462507031 4707 LKDLILQKGITQNALDYMKKHIPSAKNL---DADIWKKFLSRPALPFILRLLRGLAIQHPGTQVLIGTDSIPNLHKLEQV 4783
Cdd:pfam13764  314 LKDLILEKGIVKSALDYLLEHFPEVKQAlftDSDEWKEFLSKPSLPYILRLLTGLAMGHEPTQLCVAETIIPLLHRLEQV 393
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462507031 4784 SSDEGIGTLAENLLEALRE-HPDVNKKIDAARRETRAEKKRMAMAMRQKALGTLGMTTNEKGQVVTKTALLKQMEELIEE 4862
Cdd:pfam13764  394 SSEEHIGSLAENLLEALAEkNPKVAEKIEEVRKETRDEKKRLAMAKREKQLGALGMRTNDGGQVIVSPSILEQLEDLEEE 473
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462507031 4863 PGLTCCICREGYKFQPTKVLGIYTFTKRVALEELENKPRKQQGYSTVSHFNIVHYDCHLAAVR---LARGREEWESAALQ 4939
Cdd:pfam13764  474 DGLTCMICREGYKFQPTKVLGIYTFSKRVNLEEFETKPRKTYGYTTVSHFNVIHFDCHQSAVRadaLARPRDEWEGAALR 553
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462507031 4940 NANTKCNGLLPVWGPHVPESAFATCLARHNTYLQECTGQREPTYQLNIHDIKLLFLRFAMEQSFSADTGGGGRESNIHLI 5019
Cdd:pfam13764  554 NANTKCNGLLPLWGPSVPESAFASCLDRHWTYLQECTRARGPRYRLLTHDLKLLLLRFATEASFSEDSGGGGRESNMRLL 633
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462507031 5020 PYIIHTVLYVLNTTRATSREEKNLQGFL-EQPKEKWVESAFEVDGPYYFTVLALHILPPEQWRATRVEILRRLLVTSQAR 5098
Cdd:pfam13764  634 PYLIHMALYLLNTTRSRPREEKSLSAYLrPPPPEKWVESAYEVEGPLYMLVLSLLLESYDSWKEHRLNFLRRLLVYAQTR 713
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462507031 5099 AVAPGGATRLTDKAVKDYSAYRSSLLFWALVDLIYNMFKKVPTSNTEGGWSCSLAEYIRHNDMPIYEAADKALKTFQEEF 5178
Cdd:pfam13764  714 HTSPSGTNRLSDKKVKLYSIYKPMLIFFGLIDKLYNIFKKKVSVSSLEGWEVSLAEYLRHNDEAMLEFSKKLLSWLEEEL 793
                          810
                   ....*....|....
gi 2462507031 5179 MPVETFSEFLDVAG 5192
Cdd:pfam13764  794 LPCEDFQEFCDVTG 807
UBR-box_UBR4 cd19680
UBR-box found in RING-type E3 ubiquitin-protein ligase UBR4 and similar proteins; UBR4 (EC 2.3. ...
1660-1730 6.08e-56

UBR-box found in RING-type E3 ubiquitin-protein ligase UBR4 and similar proteins; UBR4 (EC 2.3.2.27; also called 600 kDa retinoblastoma protein-associated factor, N-recognin-4, retinoblastoma-associated factor of 600 kDa, RBAF600, p600, or zinc finger UBR1-type protein 1) is a RING-type E3 ubiquitin ligase of the Arg/N-end rule degradation pathway. It recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. UBR4 acts as a multifunctional protein with roles in anoikis, viral transformation, and protein degradation, as well as in neurogenesis, neuronal migration, neuronal signaling, and survival.


:

Pssm-ID: 439078  Cd Length: 71  Bit Score: 189.59  E-value: 6.08e-56
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462507031 1660 KLCTFTITQKEFMNQHWYHCHTCKMVDGVGVCTVCAKVCHKDHEISYAKYGSFFCDCGAKEDGSCLALVKR 1730
Cdd:cd19680      1 KLCTFTITQKEFMNQHWYHCHTCKMVDGVGVCSVCAKVCHKDHDLSYAKYGSFFCDCGAKEDGSCQALVKR 71
DZR pfam12773
Double zinc ribbon; This family consists of a pair of zinc ribbon domains.
3689-3733 1.41e-04

Double zinc ribbon; This family consists of a pair of zinc ribbon domains.


:

Pssm-ID: 432773 [Multi-domain]  Cd Length: 45  Bit Score: 42.36  E-value: 1.41e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 2462507031 3689 CPRCSASVPANPGVCGNCGENV--YQCHKCRSINyDEKDPFlCNACG 3733
Cdd:pfam12773    1 CPNCGHPNPPGAKFCPACGTPLkpDRCPNCGAPV-PPNARF-CPYCG 45
 
Name Accession Description Interval E-value
E3_UBR4_N pfam19423
E3 ubiquitin-protein ligase UBR4 N-terminal; This entry represents the N-terminal of E3 ...
69-1650 0e+00

E3 ubiquitin-protein ligase UBR4 N-terminal; This entry represents the N-terminal of E3 ubiquitin-protein ligases UBR4 (POE or PUSHOVER in Drosophila), which are components of the N-rule pathway, identified as noncanonical N-recognins implicated in bulk lysosomal degradation and autophagy. These are extraordinarily large proteins that recognize and bind to proteins with N-terminal destabilising residues according to the N-end rule leading them to their ubiquitination and degradation. These proteins share a UBR box (pfam02207) with others E3-ligases UBR box proteins but UBR4 lacks the ubiquitylation domain, suggesting that it may interact with other catalytic proteins.


Pssm-ID: 466074  Cd Length: 1598  Bit Score: 2597.99  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462507031   69 QYEPFYSSFVALSTHYITTVCSLIPRNQLQSVAAACKVLIEFSLLRLENPDEACAVSQKHLILLIKGLCTGCSRLDRTEI 148
Cdd:pfam19423    1 QYEPFYSSFVALASHYISTVAGSVPRNQLGSVSSACRVLLKFLLLRLQNPDDACAVSQKHLMMLIKALCTGCSRLDKADV 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462507031  149 ITFTAMMKSAKLPQTVKTLSDvEDQKELASPVSPELRQKEVQMNFLNQLTSVFNPRTVAS---QPISTQTLVEGENDEQS 225
Cdd:pfam19423   81 ITFTAMLRSAKAPQTIKELDT-EDQKELASEVQPELRQKETGMDIFDQLTSVFNEVSVSSphkAEPVVDPLAEGDTDHQR 159
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462507031  226 StdQASAIKTKNVFIAQNVASLQELGGSEKLLRVCLNLPYFLRYINRFQDAVLANSFfIMPATVADATAVRNGFHSLVID 305
Cdd:pfam19423  160 H--QASSEKLKNAFGKRNVSSLLQLDGSEILVDVCLNLTFLLRYSQRFKDAVAGNSF-IMPATLADALTVRNSYQSLLID 236
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462507031  306 VTMALDTLSLPVLEPLNPSRLQDVTVLSLSCLYAGVSVATCMAILHVGSAQQVRtgSTSSKEDDYESDAATIVQKCLEIY 385
Cdd:pfam19423  237 ISIAWRAFSLPVLEPLTPKRLEKITVITLSCLYASVSVAMCNAVLALTSTQPAK--STSSKDEEIDNYGATIVQKSLEIF 314
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462507031  386 DMIGQAISSSRRAGGEHYQNFQLLGAWCLLNSLFLILNLSPTALADKGKEKDPLAALRVRDILSRTKEGVGSPKLGPGKG 465
Cdd:pfam19423  315 NMISQAISNSTRAGGNHYQNLNLLGAWLLLNGLQLILNLTPTTLLERGKEKDPLAALRPSDIGTKTKEGQGSPKLGPKSG 394
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462507031  466 HQGFGVLSVILANHAIKLLTSLFQDLQVEALHK---GWETDGPPAALSIMAQSTSIQRIQRLIDSVPLMNLLLTLLSTSY 542
Cdd:pfam19423  395 HQGFGVLSVILANKAVQLLTELLQDLQVEGLHPdlgGWAPDGPPAVLTIMAQSTAIQRVQKLIDSVPLTDLLFTLVSTSF 474
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462507031  543 RKACVLQRQRKGSMSSDASASTDS--NTYYEDDFSSTEEDSSQDDDSEPILGQWFEETISPSKEKAAPPPPPPPPPLESS 620
Cdd:pfam19423  475 RKASVLQRLKQGSESSEASSSSASdsNTFYEDDFSSTEESSDEDEDSEPILGQWFEETISPSKTKVAPPPPPPPPPLEDS 554
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462507031  621 PRVKSPSKQAPGEKGNILASRKDPELFLGLASNILNFITSSMLNSRNNFIRNYLSVSLSEHHMATLASIIKEVDKDGLKG 700
Cdd:pfam19423  555 PREKSPSKQSPGDSGNILPDKKDPEGFVGLASDILNFLSQSFLNSRDNELQKYLSSSLNEDHMATLASLIKELDRDCIKG 634
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462507031  701 SSDEE---FAAALYHFNHSLVTSDLQSPNLQNTLLQQLGVAPFSEGPWPLYIHPQSLSVLSRLLLIWQHK---ASAQGDP 774
Cdd:pfam19423  635 SSDKVfdgLSIALAKFNHNLISSGLLSPNLQDTLLQQLGVAPFAVGPWPLTIHPRTLAVLAELLLLKQQKereAKLQKSQ 714
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462507031  775 DVPECLKVWDRFLSTMKQNAL-QGVVPSETeDLNVEHLQMLLLIFHNFTETGRRAILSLFVQIIQE-LSVNMDAQMRFVP 852
Cdd:pfam19423  715 SEAAVIKVWVRFITTLKSNIIlDGQVDSED-DINVEHLQLLLFLFHSLPLMGKKSLLLQLAQNIIAiNEMDIEKLENMVP 793
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462507031  853 LILARLLLIFDYLLHQYSKAPVYLFEQVQHNLLSPPFGWASGSQDSNSRRAttPLYHGFKEVEENWSKHFS----SDAVP 928
Cdd:pfam19423  794 LPLTRLLLVFEYLLHYFYDPPPELFEQVRWNLFTPPAQTASGEQDGLSRRQ--TLFFGCREVEENYRRHLTaqeiSDAVQ 871
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462507031  929 HPRFYCVLSPEASEDDLNRLDSVACDVLFSKL--VKYDELYAALTALLAAGSQLDTVRRKENKNVTALEACALQYYFLIL 1006
Cdd:pfam19423  872 QPRFYNLGPPEVNEQDTPKVDGLACSFLLSSAdvVKYNELYDACISLLMAGSQCDTVRRKENKKLSILDACALHYHFLVL 951
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462507031 1007 WRILGILPPSKTYINQLSMNSPEMSECDILHTLRWSSRLRISSYVNWIKDHLIKQGMKAEHASSLLELASTtKCSSVKYD 1086
Cdd:pfam19423  952 WRLLACLPPSIQYLRMLESGELDMSNSDILHTLRWSSRLRHKVFVNWMKDHLVKQGLTTQQAESLLTSANK-KCNNVKYD 1030
                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462507031 1087 VEIVEEYFARQISSFCSIDCTTILQLHEIPSLQSIYTLDAAISKVQVSLDEHFSKMAAETDPHKSSEITKNLLPATLQLI 1166
Cdd:pfam19423 1031 VRLAEEFLARQISSFLSIDPKEILPLTDLPGLQSVYTLDAVIAKVQVSLEETFTKAMADIDPHKAMEIAKNLLPATLQLI 1110
                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462507031 1167 DTYASFTRAYLLQNFNEEGTTE-KPSKEKLQGFAAVLAIGSSRCKANT-LGPTLVQNLPSSVQTVCESWNNINTNEFPNI 1244
Cdd:pfam19423 1111 ETYTVFVRSCILHQLKEEGDTEmVLTPEKLDGYGAVLSIGSTRPSKVSvLGADIMQTLPRPVQLACEKWNSITTNEFPSI 1190
                         1210      1220      1230      1240      1250      1260      1270      1280
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462507031 1245 GSWRNAFANDTIPSESYISAVQAAHLGTLCSQSLPLAASLKHTLLSLVRLTGDLIVWSDEMNPPQVIRTLLPLLLESSTE 1324
Cdd:pfam19423 1191 GAWRNAFANDIIPSESYIDAVQAAHLGTLSEQSFPIAASLKHTLLSLVRFTSDLIVWCPETNPKEMIRVMFPLLLDASTA 1270
                         1290      1300      1310      1320      1330      1340      1350      1360
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462507031 1325 SVAEISSNSLERILGPAESDEFLARVYEKLITGCYNILANHADPNSGLDESILEECLQYLEKQLESSQARKAMEEFFSDS 1404
Cdd:pfam19423 1271 YVADMSSQSLERFLGPVDSDEFMERTYEYLFSVCYDLCANHSEPQSGLDESVLEECLKFMENHIEKSQERKAFEEFFSES 1350
                         1370      1380      1390      1400      1410      1420      1430      1440
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462507031 1405 GELVQIMMATANENLSAKFCNRVLKFFTKLFQLTEKSPNPSLLHLCGSLAQLACVEPVRLQAWLTRMtTSPPKDSDQLDV 1484
Cdd:pfam19423 1351 GDLVQLMLSTAKENLSAKFCNRVLRFFTKLFQLTEKSPDKSYEVLCGSLSQLACVDPSRLQNWLTKM-IAPSEDSEQLNT 1429
                         1450      1460      1470      1480      1490      1500      1510      1520
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462507031 1485 IQENRQLLQLLTTYIVRENSQVGEGVCAVLLGTLTPMATEMLANGDG--TGFPELMVVMATLASAGQGAGHLQLHNAAVD 1562
Cdd:pfam19423 1430 LQENRQLLRTLTTHIVKENSQVSEKVCLVLLCTLIPMGTILLAGGDGeiTGFPELMMVMHTLAGAGQGAGHLQLFQAATD 1509
                         1530      1540      1550      1560      1570      1580      1590      1600
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462507031 1563 WLSRCKKYLSQKNVVEKLNANVMHGKHVMILECTCHIMSYLADVTNALSQSNGQGPSHLSVDGEERAIEV-DSDWVEELA 1641
Cdd:pfam19423 1510 WLDRCKKYLNKKEVLEKMTSNNGHGKHPAVLDCLCCILSYLGEILGALKQSSGQGGSSLPVDGDEAAPEVgDSDWVEDLT 1589

                   ....*....
gi 2462507031 1642 VEEEDSQAE 1650
Cdd:pfam19423 1590 VEEDDSQGE 1598
E3_UbLigase_R4 pfam13764
E3 ubiquitin-protein ligase UBR4; This is a family of E3 ubiquitin ligase enzymes.
4396-5192 0e+00

E3 ubiquitin-protein ligase UBR4; This is a family of E3 ubiquitin ligase enzymes.


Pssm-ID: 433459  Cd Length: 807  Bit Score: 1339.21  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462507031 4396 MPGNPYSSNEPGIGPLMRDIKNKICQDCDLVALLEDDSGMELLVNNKIISLDLPVAEVYKKVWCTT-NEGEPMRIVYRMR 4474
Cdd:pfam13764    1 MLGNPYSSNEPGLGPLMRDVKNKICQDCELVALLEDDNGMELLVNNKIISLDLPVKDVYEKVWKKEnNEGEPMRVVYRMR 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462507031 4475 GLLGDATEEFIESLDSTTDEEEDEEEVYKMAGVMAQCGGLECMLNRLAGIRDFKQGRHLLTVLLKLFSYCVKVKVNRQQL 4554
Cdd:pfam13764   81 GLDGDATEEFIEELEDDSEEEVDPEEEYKMANVMAECGGLEVMLSRLATIRDLSSGRELLQVLLKLLSYCVKIKVNRQAL 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462507031 4555 vkLEMNTLNVMLGTLNLALVAEQEskdsgGAAVAEQVLSIMEIILDESNAEPLSEDKGNLLLT------GDKDQLVMLLD 4628
Cdd:pfam13764  161 --LKLGALGVLLETLKLAFSAEQE-----GPEIAEQLLLIMESILSEANESDLEGSTQSSLTThekrgeGAKEQVLMLLD 233
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462507031 4629 QINSTFVRSNPSVLQGLLRIIPYLSFGEVEKMQILVERFKPYCNFDKYDE--DHSGDDKVFLDCFCKIAAGIKNNSNGHQ 4706
Cdd:pfam13764  234 RLNSPFVRKNQSVLQALTRIIPFLTYGEEEKMAALVDHFKPYLNFEKFDElqSHTAEQQFHLECFCRIAEGIENNSNGNR 313
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462507031 4707 LKDLILQKGITQNALDYMKKHIPSAKNL---DADIWKKFLSRPALPFILRLLRGLAIQHPGTQVLIGTDSIPNLHKLEQV 4783
Cdd:pfam13764  314 LKDLILEKGIVKSALDYLLEHFPEVKQAlftDSDEWKEFLSKPSLPYILRLLTGLAMGHEPTQLCVAETIIPLLHRLEQV 393
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462507031 4784 SSDEGIGTLAENLLEALRE-HPDVNKKIDAARRETRAEKKRMAMAMRQKALGTLGMTTNEKGQVVTKTALLKQMEELIEE 4862
Cdd:pfam13764  394 SSEEHIGSLAENLLEALAEkNPKVAEKIEEVRKETRDEKKRLAMAKREKQLGALGMRTNDGGQVIVSPSILEQLEDLEEE 473
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462507031 4863 PGLTCCICREGYKFQPTKVLGIYTFTKRVALEELENKPRKQQGYSTVSHFNIVHYDCHLAAVR---LARGREEWESAALQ 4939
Cdd:pfam13764  474 DGLTCMICREGYKFQPTKVLGIYTFSKRVNLEEFETKPRKTYGYTTVSHFNVIHFDCHQSAVRadaLARPRDEWEGAALR 553
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462507031 4940 NANTKCNGLLPVWGPHVPESAFATCLARHNTYLQECTGQREPTYQLNIHDIKLLFLRFAMEQSFSADTGGGGRESNIHLI 5019
Cdd:pfam13764  554 NANTKCNGLLPLWGPSVPESAFASCLDRHWTYLQECTRARGPRYRLLTHDLKLLLLRFATEASFSEDSGGGGRESNMRLL 633
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462507031 5020 PYIIHTVLYVLNTTRATSREEKNLQGFL-EQPKEKWVESAFEVDGPYYFTVLALHILPPEQWRATRVEILRRLLVTSQAR 5098
Cdd:pfam13764  634 PYLIHMALYLLNTTRSRPREEKSLSAYLrPPPPEKWVESAYEVEGPLYMLVLSLLLESYDSWKEHRLNFLRRLLVYAQTR 713
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462507031 5099 AVAPGGATRLTDKAVKDYSAYRSSLLFWALVDLIYNMFKKVPTSNTEGGWSCSLAEYIRHNDMPIYEAADKALKTFQEEF 5178
Cdd:pfam13764  714 HTSPSGTNRLSDKKVKLYSIYKPMLIFFGLIDKLYNIFKKKVSVSSLEGWEVSLAEYLRHNDEAMLEFSKKLLSWLEEEL 793
                          810
                   ....*....|....
gi 2462507031 5179 MPVETFSEFLDVAG 5192
Cdd:pfam13764  794 LPCEDFQEFCDVTG 807
UBR-box_UBR4 cd19680
UBR-box found in RING-type E3 ubiquitin-protein ligase UBR4 and similar proteins; UBR4 (EC 2.3. ...
1660-1730 6.08e-56

UBR-box found in RING-type E3 ubiquitin-protein ligase UBR4 and similar proteins; UBR4 (EC 2.3.2.27; also called 600 kDa retinoblastoma protein-associated factor, N-recognin-4, retinoblastoma-associated factor of 600 kDa, RBAF600, p600, or zinc finger UBR1-type protein 1) is a RING-type E3 ubiquitin ligase of the Arg/N-end rule degradation pathway. It recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. UBR4 acts as a multifunctional protein with roles in anoikis, viral transformation, and protein degradation, as well as in neurogenesis, neuronal migration, neuronal signaling, and survival.


Pssm-ID: 439078  Cd Length: 71  Bit Score: 189.59  E-value: 6.08e-56
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462507031 1660 KLCTFTITQKEFMNQHWYHCHTCKMVDGVGVCTVCAKVCHKDHEISYAKYGSFFCDCGAKEDGSCLALVKR 1730
Cdd:cd19680      1 KLCTFTITQKEFMNQHWYHCHTCKMVDGVGVCSVCAKVCHKDHDLSYAKYGSFFCDCGAKEDGSCQALVKR 71
ZnF_UBR1 smart00396
Putative zinc finger in N-recognin, a recognition component of the N-end rule pathway; Domain ...
1660-1727 4.18e-16

Putative zinc finger in N-recognin, a recognition component of the N-end rule pathway; Domain is involved in recognition of N-end rule substrates in yeast Ubr1p


Pssm-ID: 197698  Cd Length: 71  Bit Score: 75.94  E-value: 4.18e-16
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2462507031  1660 KLCTFTITQKEFMnqhwYHCHTCKMVDGVGVCTVCA-KVCHKDHEISYA-KYGSFFCDCGAKE----DGSCLAL 1727
Cdd:smart00396    1 DVCGYKFTGGEVI----YRCKTCGLDPTCVLCSDCFrPSCHKGHDVSLKtSRGSGICDCGDKEawneDLKCKAH 70
zf-UBR pfam02207
Putative zinc finger in N-recognin (UBR box); This region is found in E3 ubiquitin ligases ...
1662-1724 3.01e-10

Putative zinc finger in N-recognin (UBR box); This region is found in E3 ubiquitin ligases that recognize N-recognins.


Pssm-ID: 460491  Cd Length: 68  Bit Score: 58.84  E-value: 3.01e-10
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2462507031 1662 CTFTITqkefMNQHWYHCHTCKMVDGVGVCTVCAKVC-HKDHEIS-YAKYGSFFCDCG----AKEDGSC 1724
Cdd:pfam02207    1 CGYVFK----KGQPVYRCLTCSLDPTCVICYSCFINCdHEGHDYElFTSRGGGCCDCGdpeaWKEEGFC 65
DZR pfam12773
Double zinc ribbon; This family consists of a pair of zinc ribbon domains.
3689-3733 1.41e-04

Double zinc ribbon; This family consists of a pair of zinc ribbon domains.


Pssm-ID: 432773 [Multi-domain]  Cd Length: 45  Bit Score: 42.36  E-value: 1.41e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 2462507031 3689 CPRCSASVPANPGVCGNCGENV--YQCHKCRSINyDEKDPFlCNACG 3733
Cdd:pfam12773    1 CPNCGHPNPPGAKFCPACGTPLkpDRCPNCGAPV-PPNARF-CPYCG 45
PHA03018 PHA03018
hypothetical protein; Provisional
4596-4714 1.68e-03

hypothetical protein; Provisional


Pssm-ID: 165317  Cd Length: 174  Bit Score: 42.76  E-value: 1.68e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462507031 4596 EIILDESNAEPLSEDKGNLLL-TGDKDQlvMLLDQIN--STFVRSNPSVLQGLLRIIPYLSFGEVEKMQ--ILVERFKPY 4670
Cdd:PHA03018    35 DIDLDISDYNFDSDDIGLLIInINDKKK--MLVEKIHipDKYLDEDKIKIDKLFDNDKIKSLSEDEKLKdnIFIEIEKQK 112
                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|
gi 2462507031 4671 CNFDkYDEDHSGDDKVFLDCF---CKIAAG---IKNNSNGHQLKDLILQK 4714
Cdd:PHA03018   113 NNFN-YEEDESNDNNLIIDCFpeeCKICNNkikIDNEFNNDNVEMQIICD 161
 
Name Accession Description Interval E-value
E3_UBR4_N pfam19423
E3 ubiquitin-protein ligase UBR4 N-terminal; This entry represents the N-terminal of E3 ...
69-1650 0e+00

E3 ubiquitin-protein ligase UBR4 N-terminal; This entry represents the N-terminal of E3 ubiquitin-protein ligases UBR4 (POE or PUSHOVER in Drosophila), which are components of the N-rule pathway, identified as noncanonical N-recognins implicated in bulk lysosomal degradation and autophagy. These are extraordinarily large proteins that recognize and bind to proteins with N-terminal destabilising residues according to the N-end rule leading them to their ubiquitination and degradation. These proteins share a UBR box (pfam02207) with others E3-ligases UBR box proteins but UBR4 lacks the ubiquitylation domain, suggesting that it may interact with other catalytic proteins.


Pssm-ID: 466074  Cd Length: 1598  Bit Score: 2597.99  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462507031   69 QYEPFYSSFVALSTHYITTVCSLIPRNQLQSVAAACKVLIEFSLLRLENPDEACAVSQKHLILLIKGLCTGCSRLDRTEI 148
Cdd:pfam19423    1 QYEPFYSSFVALASHYISTVAGSVPRNQLGSVSSACRVLLKFLLLRLQNPDDACAVSQKHLMMLIKALCTGCSRLDKADV 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462507031  149 ITFTAMMKSAKLPQTVKTLSDvEDQKELASPVSPELRQKEVQMNFLNQLTSVFNPRTVAS---QPISTQTLVEGENDEQS 225
Cdd:pfam19423   81 ITFTAMLRSAKAPQTIKELDT-EDQKELASEVQPELRQKETGMDIFDQLTSVFNEVSVSSphkAEPVVDPLAEGDTDHQR 159
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462507031  226 StdQASAIKTKNVFIAQNVASLQELGGSEKLLRVCLNLPYFLRYINRFQDAVLANSFfIMPATVADATAVRNGFHSLVID 305
Cdd:pfam19423  160 H--QASSEKLKNAFGKRNVSSLLQLDGSEILVDVCLNLTFLLRYSQRFKDAVAGNSF-IMPATLADALTVRNSYQSLLID 236
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462507031  306 VTMALDTLSLPVLEPLNPSRLQDVTVLSLSCLYAGVSVATCMAILHVGSAQQVRtgSTSSKEDDYESDAATIVQKCLEIY 385
Cdd:pfam19423  237 ISIAWRAFSLPVLEPLTPKRLEKITVITLSCLYASVSVAMCNAVLALTSTQPAK--STSSKDEEIDNYGATIVQKSLEIF 314
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462507031  386 DMIGQAISSSRRAGGEHYQNFQLLGAWCLLNSLFLILNLSPTALADKGKEKDPLAALRVRDILSRTKEGVGSPKLGPGKG 465
Cdd:pfam19423  315 NMISQAISNSTRAGGNHYQNLNLLGAWLLLNGLQLILNLTPTTLLERGKEKDPLAALRPSDIGTKTKEGQGSPKLGPKSG 394
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462507031  466 HQGFGVLSVILANHAIKLLTSLFQDLQVEALHK---GWETDGPPAALSIMAQSTSIQRIQRLIDSVPLMNLLLTLLSTSY 542
Cdd:pfam19423  395 HQGFGVLSVILANKAVQLLTELLQDLQVEGLHPdlgGWAPDGPPAVLTIMAQSTAIQRVQKLIDSVPLTDLLFTLVSTSF 474
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462507031  543 RKACVLQRQRKGSMSSDASASTDS--NTYYEDDFSSTEEDSSQDDDSEPILGQWFEETISPSKEKAAPPPPPPPPPLESS 620
Cdd:pfam19423  475 RKASVLQRLKQGSESSEASSSSASdsNTFYEDDFSSTEESSDEDEDSEPILGQWFEETISPSKTKVAPPPPPPPPPLEDS 554
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462507031  621 PRVKSPSKQAPGEKGNILASRKDPELFLGLASNILNFITSSMLNSRNNFIRNYLSVSLSEHHMATLASIIKEVDKDGLKG 700
Cdd:pfam19423  555 PREKSPSKQSPGDSGNILPDKKDPEGFVGLASDILNFLSQSFLNSRDNELQKYLSSSLNEDHMATLASLIKELDRDCIKG 634
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462507031  701 SSDEE---FAAALYHFNHSLVTSDLQSPNLQNTLLQQLGVAPFSEGPWPLYIHPQSLSVLSRLLLIWQHK---ASAQGDP 774
Cdd:pfam19423  635 SSDKVfdgLSIALAKFNHNLISSGLLSPNLQDTLLQQLGVAPFAVGPWPLTIHPRTLAVLAELLLLKQQKereAKLQKSQ 714
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462507031  775 DVPECLKVWDRFLSTMKQNAL-QGVVPSETeDLNVEHLQMLLLIFHNFTETGRRAILSLFVQIIQE-LSVNMDAQMRFVP 852
Cdd:pfam19423  715 SEAAVIKVWVRFITTLKSNIIlDGQVDSED-DINVEHLQLLLFLFHSLPLMGKKSLLLQLAQNIIAiNEMDIEKLENMVP 793
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462507031  853 LILARLLLIFDYLLHQYSKAPVYLFEQVQHNLLSPPFGWASGSQDSNSRRAttPLYHGFKEVEENWSKHFS----SDAVP 928
Cdd:pfam19423  794 LPLTRLLLVFEYLLHYFYDPPPELFEQVRWNLFTPPAQTASGEQDGLSRRQ--TLFFGCREVEENYRRHLTaqeiSDAVQ 871
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462507031  929 HPRFYCVLSPEASEDDLNRLDSVACDVLFSKL--VKYDELYAALTALLAAGSQLDTVRRKENKNVTALEACALQYYFLIL 1006
Cdd:pfam19423  872 QPRFYNLGPPEVNEQDTPKVDGLACSFLLSSAdvVKYNELYDACISLLMAGSQCDTVRRKENKKLSILDACALHYHFLVL 951
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462507031 1007 WRILGILPPSKTYINQLSMNSPEMSECDILHTLRWSSRLRISSYVNWIKDHLIKQGMKAEHASSLLELASTtKCSSVKYD 1086
Cdd:pfam19423  952 WRLLACLPPSIQYLRMLESGELDMSNSDILHTLRWSSRLRHKVFVNWMKDHLVKQGLTTQQAESLLTSANK-KCNNVKYD 1030
                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462507031 1087 VEIVEEYFARQISSFCSIDCTTILQLHEIPSLQSIYTLDAAISKVQVSLDEHFSKMAAETDPHKSSEITKNLLPATLQLI 1166
Cdd:pfam19423 1031 VRLAEEFLARQISSFLSIDPKEILPLTDLPGLQSVYTLDAVIAKVQVSLEETFTKAMADIDPHKAMEIAKNLLPATLQLI 1110
                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462507031 1167 DTYASFTRAYLLQNFNEEGTTE-KPSKEKLQGFAAVLAIGSSRCKANT-LGPTLVQNLPSSVQTVCESWNNINTNEFPNI 1244
Cdd:pfam19423 1111 ETYTVFVRSCILHQLKEEGDTEmVLTPEKLDGYGAVLSIGSTRPSKVSvLGADIMQTLPRPVQLACEKWNSITTNEFPSI 1190
                         1210      1220      1230      1240      1250      1260      1270      1280
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462507031 1245 GSWRNAFANDTIPSESYISAVQAAHLGTLCSQSLPLAASLKHTLLSLVRLTGDLIVWSDEMNPPQVIRTLLPLLLESSTE 1324
Cdd:pfam19423 1191 GAWRNAFANDIIPSESYIDAVQAAHLGTLSEQSFPIAASLKHTLLSLVRFTSDLIVWCPETNPKEMIRVMFPLLLDASTA 1270
                         1290      1300      1310      1320      1330      1340      1350      1360
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462507031 1325 SVAEISSNSLERILGPAESDEFLARVYEKLITGCYNILANHADPNSGLDESILEECLQYLEKQLESSQARKAMEEFFSDS 1404
Cdd:pfam19423 1271 YVADMSSQSLERFLGPVDSDEFMERTYEYLFSVCYDLCANHSEPQSGLDESVLEECLKFMENHIEKSQERKAFEEFFSES 1350
                         1370      1380      1390      1400      1410      1420      1430      1440
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462507031 1405 GELVQIMMATANENLSAKFCNRVLKFFTKLFQLTEKSPNPSLLHLCGSLAQLACVEPVRLQAWLTRMtTSPPKDSDQLDV 1484
Cdd:pfam19423 1351 GDLVQLMLSTAKENLSAKFCNRVLRFFTKLFQLTEKSPDKSYEVLCGSLSQLACVDPSRLQNWLTKM-IAPSEDSEQLNT 1429
                         1450      1460      1470      1480      1490      1500      1510      1520
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462507031 1485 IQENRQLLQLLTTYIVRENSQVGEGVCAVLLGTLTPMATEMLANGDG--TGFPELMVVMATLASAGQGAGHLQLHNAAVD 1562
Cdd:pfam19423 1430 LQENRQLLRTLTTHIVKENSQVSEKVCLVLLCTLIPMGTILLAGGDGeiTGFPELMMVMHTLAGAGQGAGHLQLFQAATD 1509
                         1530      1540      1550      1560      1570      1580      1590      1600
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462507031 1563 WLSRCKKYLSQKNVVEKLNANVMHGKHVMILECTCHIMSYLADVTNALSQSNGQGPSHLSVDGEERAIEV-DSDWVEELA 1641
Cdd:pfam19423 1510 WLDRCKKYLNKKEVLEKMTSNNGHGKHPAVLDCLCCILSYLGEILGALKQSSGQGGSSLPVDGDEAAPEVgDSDWVEDLT 1589

                   ....*....
gi 2462507031 1642 VEEEDSQAE 1650
Cdd:pfam19423 1590 VEEDDSQGE 1598
E3_UbLigase_R4 pfam13764
E3 ubiquitin-protein ligase UBR4; This is a family of E3 ubiquitin ligase enzymes.
4396-5192 0e+00

E3 ubiquitin-protein ligase UBR4; This is a family of E3 ubiquitin ligase enzymes.


Pssm-ID: 433459  Cd Length: 807  Bit Score: 1339.21  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462507031 4396 MPGNPYSSNEPGIGPLMRDIKNKICQDCDLVALLEDDSGMELLVNNKIISLDLPVAEVYKKVWCTT-NEGEPMRIVYRMR 4474
Cdd:pfam13764    1 MLGNPYSSNEPGLGPLMRDVKNKICQDCELVALLEDDNGMELLVNNKIISLDLPVKDVYEKVWKKEnNEGEPMRVVYRMR 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462507031 4475 GLLGDATEEFIESLDSTTDEEEDEEEVYKMAGVMAQCGGLECMLNRLAGIRDFKQGRHLLTVLLKLFSYCVKVKVNRQQL 4554
Cdd:pfam13764   81 GLDGDATEEFIEELEDDSEEEVDPEEEYKMANVMAECGGLEVMLSRLATIRDLSSGRELLQVLLKLLSYCVKIKVNRQAL 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462507031 4555 vkLEMNTLNVMLGTLNLALVAEQEskdsgGAAVAEQVLSIMEIILDESNAEPLSEDKGNLLLT------GDKDQLVMLLD 4628
Cdd:pfam13764  161 --LKLGALGVLLETLKLAFSAEQE-----GPEIAEQLLLIMESILSEANESDLEGSTQSSLTThekrgeGAKEQVLMLLD 233
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462507031 4629 QINSTFVRSNPSVLQGLLRIIPYLSFGEVEKMQILVERFKPYCNFDKYDE--DHSGDDKVFLDCFCKIAAGIKNNSNGHQ 4706
Cdd:pfam13764  234 RLNSPFVRKNQSVLQALTRIIPFLTYGEEEKMAALVDHFKPYLNFEKFDElqSHTAEQQFHLECFCRIAEGIENNSNGNR 313
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462507031 4707 LKDLILQKGITQNALDYMKKHIPSAKNL---DADIWKKFLSRPALPFILRLLRGLAIQHPGTQVLIGTDSIPNLHKLEQV 4783
Cdd:pfam13764  314 LKDLILEKGIVKSALDYLLEHFPEVKQAlftDSDEWKEFLSKPSLPYILRLLTGLAMGHEPTQLCVAETIIPLLHRLEQV 393
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462507031 4784 SSDEGIGTLAENLLEALRE-HPDVNKKIDAARRETRAEKKRMAMAMRQKALGTLGMTTNEKGQVVTKTALLKQMEELIEE 4862
Cdd:pfam13764  394 SSEEHIGSLAENLLEALAEkNPKVAEKIEEVRKETRDEKKRLAMAKREKQLGALGMRTNDGGQVIVSPSILEQLEDLEEE 473
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462507031 4863 PGLTCCICREGYKFQPTKVLGIYTFTKRVALEELENKPRKQQGYSTVSHFNIVHYDCHLAAVR---LARGREEWESAALQ 4939
Cdd:pfam13764  474 DGLTCMICREGYKFQPTKVLGIYTFSKRVNLEEFETKPRKTYGYTTVSHFNVIHFDCHQSAVRadaLARPRDEWEGAALR 553
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462507031 4940 NANTKCNGLLPVWGPHVPESAFATCLARHNTYLQECTGQREPTYQLNIHDIKLLFLRFAMEQSFSADTGGGGRESNIHLI 5019
Cdd:pfam13764  554 NANTKCNGLLPLWGPSVPESAFASCLDRHWTYLQECTRARGPRYRLLTHDLKLLLLRFATEASFSEDSGGGGRESNMRLL 633
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462507031 5020 PYIIHTVLYVLNTTRATSREEKNLQGFL-EQPKEKWVESAFEVDGPYYFTVLALHILPPEQWRATRVEILRRLLVTSQAR 5098
Cdd:pfam13764  634 PYLIHMALYLLNTTRSRPREEKSLSAYLrPPPPEKWVESAYEVEGPLYMLVLSLLLESYDSWKEHRLNFLRRLLVYAQTR 713
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462507031 5099 AVAPGGATRLTDKAVKDYSAYRSSLLFWALVDLIYNMFKKVPTSNTEGGWSCSLAEYIRHNDMPIYEAADKALKTFQEEF 5178
Cdd:pfam13764  714 HTSPSGTNRLSDKKVKLYSIYKPMLIFFGLIDKLYNIFKKKVSVSSLEGWEVSLAEYLRHNDEAMLEFSKKLLSWLEEEL 793
                          810
                   ....*....|....
gi 2462507031 5179 MPVETFSEFLDVAG 5192
Cdd:pfam13764  794 LPCEDFQEFCDVTG 807
UBR-box_UBR4 cd19680
UBR-box found in RING-type E3 ubiquitin-protein ligase UBR4 and similar proteins; UBR4 (EC 2.3. ...
1660-1730 6.08e-56

UBR-box found in RING-type E3 ubiquitin-protein ligase UBR4 and similar proteins; UBR4 (EC 2.3.2.27; also called 600 kDa retinoblastoma protein-associated factor, N-recognin-4, retinoblastoma-associated factor of 600 kDa, RBAF600, p600, or zinc finger UBR1-type protein 1) is a RING-type E3 ubiquitin ligase of the Arg/N-end rule degradation pathway. It recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. UBR4 acts as a multifunctional protein with roles in anoikis, viral transformation, and protein degradation, as well as in neurogenesis, neuronal migration, neuronal signaling, and survival.


Pssm-ID: 439078  Cd Length: 71  Bit Score: 189.59  E-value: 6.08e-56
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462507031 1660 KLCTFTITQKEFMNQHWYHCHTCKMVDGVGVCTVCAKVCHKDHEISYAKYGSFFCDCGAKEDGSCLALVKR 1730
Cdd:cd19680      1 KLCTFTITQKEFMNQHWYHCHTCKMVDGVGVCSVCAKVCHKDHDLSYAKYGSFFCDCGAKEDGSCQALVKR 71
UBR-box_UBR4_like cd19674
UBR-box found in RING-type E3 ubiquitin-protein ligase UBR4 and similar proteins; UBR4 (EC 2.3. ...
1660-1730 7.85e-35

UBR-box found in RING-type E3 ubiquitin-protein ligase UBR4 and similar proteins; UBR4 (EC 2.3.2.27; also called 600 kDa retinoblastoma protein-associated factor, N-recognin-4, retinoblastoma-associated factor of 600 kDa, RBAF600, p600, or zinc finger UBR1-type protein 1) is a RING-type E3 ubiquitin ligase of the Arg/N-end rule degradation pathway. It recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. UBR4 acts as a multifunctional protein with roles in anoikis, viral transformation, and protein degradation, as well as in neurogenesis, neuronal migration, neuronal signaling, and survival. The family also includes Arabidopsis thaliana auxin transport protein BIG (also called protein attenuated shade avoidance 1, protein corymbosa1, protein dark over-expression of cab 1, protein low phosphate-resistant root 1, protein transport inhibitor response 3, or protein umbrella 1). It is a calossin-like protein required for auxin efflux and polar auxin transport (PAT) influencing auxin-mediated developmental responses in Arabidopsis.


Pssm-ID: 439072  Cd Length: 72  Bit Score: 129.00  E-value: 7.85e-35
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462507031 1660 KLCTFTITQKEFMNQHWYHCHTCKMVDGVGVCTVCAKVCHKDHEISYAKYGSFFCDCGAKED-GSCLALVKR 1730
Cdd:cd19674      1 NVCTFASTGKNYARQHWYECYTCFLNGNEGVCEVCARVCHKGHDLVYSKTSSFFCDCGAGGGpSKCKSMRKS 72
UBR-box_UBR4_5_6_7 cd19671
UBR-box found in UBR4, UBR5, UBR6/FBOX11, UBR7 and similar proteins; This family includes UBR4 ...
1662-1727 4.34e-31

UBR-box found in UBR4, UBR5, UBR6/FBOX11, UBR7 and similar proteins; This family includes UBR4 (EC 2.3.2.27), UBR5 (EC 2.3.2.26), UBR6/FBOX11 and UBR7 (EC 2.3.2.27). Both UBR4 (also called 600 kDa retinoblastoma protein-associated factor, or N-recognin-4, or retinoblastoma-associated factor of 600 kDa, or RBAF600, or p600, or zinc finger UBR1-type protein 1) and UBR7 (also called N-recognin-7) are RING-type E3 ubiquitin ligases of the Arg/N-end rule degradation pathway. They recognize and bind to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. UBR5 (also called E3 ubiquitin-protein ligase, HECT domain-containing 1, E3 ligase identified by differential display (EDD), hyperplastic discs protein homolog (HYD), progestin-induced protein, or N-recognin-5) is a HECT (homologous to E6-AP C-terminus)-type E3 ubiquitin-protein ligase that acts as a key regulator of the ubiquitin proteasome system in both cancer and developmental biology. It is required for Wnt signal responses in Drosophila and human cell lines downstream of activated Armadillo/beta-catenin. It also plays a key role in ciliogenesis by regulating centriolar satellite stability and primary cilia. UBR6 (also called FBOX11, protein arginine N-methyltransferase 9 (PRMT9), or vitiligo-associated protein 1 (VIT-1)), is an E3 ubiquitin ligase and a type II methyltransferase, which functions as a key regulator of tumor initiation and progression. UBR6 is a substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as DTL/CDT2, BCL6 and PRDM1/BLIMP1. UBR6 does not bind N-terminal signals.


Pssm-ID: 439069  Cd Length: 67  Bit Score: 118.33  E-value: 4.34e-31
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462507031 1662 CTFTITQKEFMNQHWYHCHTCKMVDGVGVCTVCAKVCHKDHEISYAKYGSFFCDCGAKEDGSCLAL 1727
Cdd:cd19671      1 CTFEKTGRKYIKQPWYHCYTCGLIDGLGVCEACARKCHKGHDLVYIGYSNFYCDCGSSGPGKCKCE 66
UBR-box_BIG_like cd19681
UBR-box found in Arabidopsis thaliana auxin transport protein BIG and similar proteins; BIG ...
1660-1730 8.98e-30

UBR-box found in Arabidopsis thaliana auxin transport protein BIG and similar proteins; BIG (also called protein attenuated shade avoidance 1, protein corymbosa1, protein dark over-expression of cab 1, protein low phosphate-resistant root 1, protein transport inhibitor response 3, or protein umbrella 1) is a calossin-like protein required for auxin efflux and polar auxin transport (PAT) influencing auxin-mediated developmental responses in Arabidopsis.


Pssm-ID: 439079  Cd Length: 74  Bit Score: 114.81  E-value: 8.98e-30
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2462507031 1660 KLCTFTITQKEFMNQHWYHCHTCKMVDGVGVCTVCAKVCHKDHEISYAKYGSFFCDCGA---KEDGSCLALVKR 1730
Cdd:cd19681      1 KVCTYVSSGSNFMEQHWYFCYTCGLVDSKGCCSVCAKVCHRGHDVVYSRYSRFFCDCGAggaKRGRPCRCLKPR 74
UBR-box cd19669
UBR-box found in UBR family of E3 ubiquitin ligases (UBR1-7) and similar proteins; The UBR-box ...
1662-1724 1.13e-21

UBR-box found in UBR family of E3 ubiquitin ligases (UBR1-7) and similar proteins; The UBR-box is a 70-residue zinc finger domain present in the UBR family of E3 ubiquitin ligases (UBR1-7, also called N-recognins) that directly binds N-terminal degradation signals (N-degrons) in substrate proteins to facilitate substrate ubiquitination and proteasomal degradation via the ubiquitin-proteasome system (UPS). UBR1 and UBR2 bind all type-1 and type-2 N-degrons. They mediate ubiquitination and proteolysis of short-lived regulators and misfolded proteins. UBR4 binds both type-1 and type-2 N-degrons and is involved in proteome-wide turnover of cell surface proteins. UBR5 preferentially binds type-1 N-degrons and mediates ubiquitination of short-lived proteins. UBR3, UBR6 (also called FBXO11), and UBR7 may not bind efficiently to N-degrons. UBR3 is a RING-type E3 ubiquitin ligase with a function in olfactory and other sensory systems. UBR6 is an E3 ubiquitin ligase and a type II methyltransferase, which functions as a key regulator of tumor initiation and progression. It does not bind N-terminal signals. UBR7 is a RING-type E3 ubiquitin ligase that may play an important role in spermiogenesis and fertilization.


Pssm-ID: 439067  Cd Length: 66  Bit Score: 91.42  E-value: 1.13e-21
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462507031 1662 CTFTITQkefMNQHWYHCHTCKMVDGVGVCTVCAKVCHKDHEISYAKYGSFFCDCGAKEDGSC 1724
Cdd:cd19669      1 CTFSITG---INQVMYHCLTCSLDDNSGICEECAKKCHEGHDVVYIGSGSGFCDCGDSSAKSG 60
ZnF_UBR1 smart00396
Putative zinc finger in N-recognin, a recognition component of the N-end rule pathway; Domain ...
1660-1727 4.18e-16

Putative zinc finger in N-recognin, a recognition component of the N-end rule pathway; Domain is involved in recognition of N-end rule substrates in yeast Ubr1p


Pssm-ID: 197698  Cd Length: 71  Bit Score: 75.94  E-value: 4.18e-16
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2462507031  1660 KLCTFTITQKEFMnqhwYHCHTCKMVDGVGVCTVCA-KVCHKDHEISYA-KYGSFFCDCGAKE----DGSCLAL 1727
Cdd:smart00396    1 DVCGYKFTGGEVI----YRCKTCGLDPTCVLCSDCFrPSCHKGHDVSLKtSRGSGICDCGDKEawneDLKCKAH 70
UBR-box_UBR6_FBXO11 cd19676
UBR-box found in F-box only protein 11 (FBXO11) and similar proteins; FBXO11 (also called UBR6, ...
1662-1718 1.19e-12

UBR-box found in F-box only protein 11 (FBXO11) and similar proteins; FBXO11 (also called UBR6, protein arginine N-methyltransferase 9 (PRMT9), or vitiligo-associated protein 1 (VIT-1)) is an E3 ubiquitin ligase and a type II methyltransferase, which functions as a key regulator of tumor initiation and progression. FBXO11 is a substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as DTL/CDT2, BCL6 and PRDM1/BLIMP1. FBXO11 does not bind N-terminal signals.


Pssm-ID: 439074  Cd Length: 69  Bit Score: 65.99  E-value: 1.19e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 2462507031 1662 CTFTIT-QKEFMNQHWYHCHTCKMVDGVGVCTVCAKVCHKDHEISYAKYGSFFCDCGA 1718
Cdd:cd19676      1 CLYKISsYTSFPMHDFYRCLTCNTTDRNAICVNCIKKCHEGHDVEFIRHDRFFCDCGA 58
UBR-box_UBR5 cd19675
UBR-box found in HECT-type E3 ubiquitin-protein ligase UBR5 and similar proteins; UBR5 (EC 2.3. ...
1658-1728 1.46e-11

UBR-box found in HECT-type E3 ubiquitin-protein ligase UBR5 and similar proteins; UBR5 (EC 2.3.2.26; also called E3 ubiquitin-protein ligase, HECT domain-containing 1, E3 ligase identified by differential display (EDD), hyperplastic discs protein homolog (HYD), progestin-induced protein, or N-recognin-5) is a HECT (homologous to E6-AP C-terminus)-type E3 ubiquitin-protein ligase that acts as a key regulator of the ubiquitin proteasome system in both cancer and developmental biology. It is required for Wnt signal responses in Drosophila and human cell lines downstream of activated Armadillo/beta-catenin. It also plays a key role in ciliogenesis by regulating centriolar satellite stability and primary cilia.


Pssm-ID: 439073  Cd Length: 76  Bit Score: 62.87  E-value: 1.46e-11
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462507031 1658 CNKLCTFTITQKEFMNQHWYHCHTCKMVDGVGVCTVCAKVCHKDHEISYAKYG-SFFCDCgaKEDGSCLALV 1728
Cdd:cd19675      5 CNDTCSFTWTGAEHINQDIFECRTCGLVGSLCCCTECARVCHKGHDCKLKRTSpTAYCDC--WEKCKCKALI 74
zf-UBR pfam02207
Putative zinc finger in N-recognin (UBR box); This region is found in E3 ubiquitin ligases ...
1662-1724 3.01e-10

Putative zinc finger in N-recognin (UBR box); This region is found in E3 ubiquitin ligases that recognize N-recognins.


Pssm-ID: 460491  Cd Length: 68  Bit Score: 58.84  E-value: 3.01e-10
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2462507031 1662 CTFTITqkefMNQHWYHCHTCKMVDGVGVCTVCAKVC-HKDHEIS-YAKYGSFFCDCG----AKEDGSC 1724
Cdd:pfam02207    1 CGYVFK----KGQPVYRCLTCSLDPTCVICYSCFINCdHEGHDYElFTSRGGGCCDCGdpeaWKEEGFC 65
UBR-box_UBR7 cd19677
UBR-box found in RING-type E3 ubiquitin-protein ligase UBR7 and similar proteins; UBR7 (EC 2.3. ...
1662-1717 1.30e-06

UBR-box found in RING-type E3 ubiquitin-protein ligase UBR7 and similar proteins; UBR7 (EC 2.3.2.27; also called N-recognin-7) is a RING-type E3 ubiquitin ligase of the Arg/N-end rule degradation pathway. It recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. UBR7 may play an important role in spermiogenesis and fertilization.


Pssm-ID: 439075  Cd Length: 71  Bit Score: 48.84  E-value: 1.30e-06
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462507031 1662 CTFTitqKEFMNQHWYHCHTC---KMVDGVGVCTVCAKVCHKDHEIS--YAKYGsFFCDCG 1717
Cdd:cd19677      2 CTYS---KGYIRQAVYACLTCtpaGADQPAGICLACSLSCHEGHELEelYTKRN-FRCDCG 58
UBR-box_UBR1_2_3 cd19670
UBR-box found in ubiquitin-protein ligase E3-alpha-1 (UBR1), E3-alpha-2 (UBR2), E3-alpha-3 ...
1662-1717 5.88e-06

UBR-box found in ubiquitin-protein ligase E3-alpha-1 (UBR1), E3-alpha-2 (UBR2), E3-alpha-3 (UBR3) and similar proteins; This family includes UBR1, UBR2, and UBR3 (all belonging to EC 2.3.2.27). Both UBR1 (also called E3alpha-I or N-recognin-1) and UBR2 (also called E3-alpha-II or N-recognin-2), are RING-type E3 ubiquitin ligases of the Arg/N-end rule degradation pathway. They recognize and bind to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. Deficiency of UBR1 causes Johanson-Blizzard syndrome. UBR2 is associated with chromatin and controls chromatin dynamics and gene expression in both germ cells and somatic cells. It plays an important role in spermatogenesis. UBR3, also called ubiquitin-protein ligase E3-alpha-III (E3alpha-III), or N-recognin-3, or zinc finger protein 650, is a RING-type E3 ubiquitin ligase with a function in olfactory and other sensory systems. It negatively regulates the mono-ubiquitination of non-muscle Myosin II, a protein associated with hearing loss in humans. It acts as a positive regulator of Hedgehog (Hh) signaling in Drosophila and vertebrates. It also plays an important role for genome stability by controlling cellular levels of the essential DNA repair protein APE1.


Pssm-ID: 439068  Cd Length: 69  Bit Score: 46.97  E-value: 5.88e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 2462507031 1662 CTFTITQKEFMnqhwYHCHTCKMVDGVGVCTVCAKV-CHKDHEISYAK-YGSFFCDCG 1717
Cdd:cd19670      1 CGKSLKKGELY----YRCLDCSLDPSSCICEECFLNgNHEGHNYSLRTsSGGGVCDCG 54
DZR pfam12773
Double zinc ribbon; This family consists of a pair of zinc ribbon domains.
3689-3733 1.41e-04

Double zinc ribbon; This family consists of a pair of zinc ribbon domains.


Pssm-ID: 432773 [Multi-domain]  Cd Length: 45  Bit Score: 42.36  E-value: 1.41e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 2462507031 3689 CPRCSASVPANPGVCGNCGENV--YQCHKCRSINyDEKDPFlCNACG 3733
Cdd:pfam12773    1 CPNCGHPNPPGAKFCPACGTPLkpDRCPNCGAPV-PPNARF-CPYCG 45
PHA03018 PHA03018
hypothetical protein; Provisional
4596-4714 1.68e-03

hypothetical protein; Provisional


Pssm-ID: 165317  Cd Length: 174  Bit Score: 42.76  E-value: 1.68e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462507031 4596 EIILDESNAEPLSEDKGNLLL-TGDKDQlvMLLDQIN--STFVRSNPSVLQGLLRIIPYLSFGEVEKMQ--ILVERFKPY 4670
Cdd:PHA03018    35 DIDLDISDYNFDSDDIGLLIInINDKKK--MLVEKIHipDKYLDEDKIKIDKLFDNDKIKSLSEDEKLKdnIFIEIEKQK 112
                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|
gi 2462507031 4671 CNFDkYDEDHSGDDKVFLDCF---CKIAAG---IKNNSNGHQLKDLILQK 4714
Cdd:PHA03018   113 NNFN-YEEDESNDNNLIIDCFpeeCKICNNkikIDNEFNNDNVEMQIICD 161
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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