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fibulin-7 isoform X1 [Homo sapiens]
CCP and EGF_CA domain-containing protein( domain architecture ID 10804527)
CCP and EGF_CA domain-containing protein
List of domain hits
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Name | Accession | Description | Interval | E-value | ||
CCP | cd00033 | Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ... |
81-135 | 4.87e-12 | ||
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function. : Pssm-ID: 153056 [Multi-domain] Cd Length: 57 Bit Score: 60.55 E-value: 4.87e-12
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EGF_CA | pfam07645 | Calcium-binding EGF domain; |
270-304 | 4.95e-09 | ||
Calcium-binding EGF domain; : Pssm-ID: 429571 Cd Length: 32 Bit Score: 51.47 E-value: 4.95e-09
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EGF_CA | cd00054 | Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ... |
137-172 | 2.54e-08 | ||
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements. : Pssm-ID: 238011 Cd Length: 38 Bit Score: 49.56 E-value: 2.54e-08
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EGF_CA | smart00179 | Calcium-binding EGF-like domain; |
224-269 | 3.25e-07 | ||
Calcium-binding EGF-like domain; : Pssm-ID: 214542 [Multi-domain] Cd Length: 39 Bit Score: 46.47 E-value: 3.25e-07
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Name | Accession | Description | Interval | E-value | ||
CCP | cd00033 | Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ... |
81-135 | 4.87e-12 | ||
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function. Pssm-ID: 153056 [Multi-domain] Cd Length: 57 Bit Score: 60.55 E-value: 4.87e-12
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CCP | smart00032 | Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ... |
81-134 | 3.31e-11 | ||
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII. Pssm-ID: 214478 [Multi-domain] Cd Length: 56 Bit Score: 58.31 E-value: 3.31e-11
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EGF_CA | pfam07645 | Calcium-binding EGF domain; |
270-304 | 4.95e-09 | ||
Calcium-binding EGF domain; Pssm-ID: 429571 Cd Length: 32 Bit Score: 51.47 E-value: 4.95e-09
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EGF_CA | cd00054 | Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ... |
137-172 | 2.54e-08 | ||
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements. Pssm-ID: 238011 Cd Length: 38 Bit Score: 49.56 E-value: 2.54e-08
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Sushi | pfam00084 | Sushi repeat (SCR repeat); |
103-134 | 2.81e-08 | ||
Sushi repeat (SCR repeat); Pssm-ID: 459664 [Multi-domain] Cd Length: 56 Bit Score: 50.19 E-value: 2.81e-08
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EGF | pfam00008 | EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ... |
140-170 | 2.61e-07 | ||
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains. Pssm-ID: 394967 Cd Length: 31 Bit Score: 46.61 E-value: 2.61e-07
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EGF_CA | smart00179 | Calcium-binding EGF-like domain; |
224-269 | 3.25e-07 | ||
Calcium-binding EGF-like domain; Pssm-ID: 214542 [Multi-domain] Cd Length: 39 Bit Score: 46.47 E-value: 3.25e-07
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EGF_CA | smart00179 | Calcium-binding EGF-like domain; |
139-172 | 8.33e-07 | ||
Calcium-binding EGF-like domain; Pssm-ID: 214542 [Multi-domain] Cd Length: 39 Bit Score: 45.32 E-value: 8.33e-07
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FXa_inhibition | pfam14670 | Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ... |
240-268 | 3.36e-06 | ||
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442. Pssm-ID: 464251 [Multi-domain] Cd Length: 36 Bit Score: 43.39 E-value: 3.36e-06
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EGF_CA | cd00054 | Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ... |
224-269 | 1.17e-05 | ||
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements. Pssm-ID: 238011 Cd Length: 38 Bit Score: 42.24 E-value: 1.17e-05
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EGF_CA | smart00179 | Calcium-binding EGF-like domain; |
270-304 | 2.69e-05 | ||
Calcium-binding EGF-like domain; Pssm-ID: 214542 [Multi-domain] Cd Length: 39 Bit Score: 41.08 E-value: 2.69e-05
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EGF_CA | cd00054 | Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ... |
270-304 | 5.26e-04 | ||
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements. Pssm-ID: 238011 Cd Length: 38 Bit Score: 37.23 E-value: 5.26e-04
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PHA02817 | PHA02817 | EEV Host range protein; Provisional |
82-134 | 6.45e-04 | ||
EEV Host range protein; Provisional Pssm-ID: 165167 [Multi-domain] Cd Length: 225 Bit Score: 41.08 E-value: 6.45e-04
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Name | Accession | Description | Interval | E-value | ||
CCP | cd00033 | Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ... |
81-135 | 4.87e-12 | ||
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function. Pssm-ID: 153056 [Multi-domain] Cd Length: 57 Bit Score: 60.55 E-value: 4.87e-12
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CCP | smart00032 | Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ... |
81-134 | 3.31e-11 | ||
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII. Pssm-ID: 214478 [Multi-domain] Cd Length: 56 Bit Score: 58.31 E-value: 3.31e-11
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EGF_CA | pfam07645 | Calcium-binding EGF domain; |
270-304 | 4.95e-09 | ||
Calcium-binding EGF domain; Pssm-ID: 429571 Cd Length: 32 Bit Score: 51.47 E-value: 4.95e-09
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EGF_CA | cd00054 | Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ... |
137-172 | 2.54e-08 | ||
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements. Pssm-ID: 238011 Cd Length: 38 Bit Score: 49.56 E-value: 2.54e-08
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Sushi | pfam00084 | Sushi repeat (SCR repeat); |
103-134 | 2.81e-08 | ||
Sushi repeat (SCR repeat); Pssm-ID: 459664 [Multi-domain] Cd Length: 56 Bit Score: 50.19 E-value: 2.81e-08
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EGF | pfam00008 | EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ... |
140-170 | 2.61e-07 | ||
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains. Pssm-ID: 394967 Cd Length: 31 Bit Score: 46.61 E-value: 2.61e-07
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EGF_CA | smart00179 | Calcium-binding EGF-like domain; |
224-269 | 3.25e-07 | ||
Calcium-binding EGF-like domain; Pssm-ID: 214542 [Multi-domain] Cd Length: 39 Bit Score: 46.47 E-value: 3.25e-07
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EGF_CA | smart00179 | Calcium-binding EGF-like domain; |
139-172 | 8.33e-07 | ||
Calcium-binding EGF-like domain; Pssm-ID: 214542 [Multi-domain] Cd Length: 39 Bit Score: 45.32 E-value: 8.33e-07
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FXa_inhibition | pfam14670 | Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ... |
240-268 | 3.36e-06 | ||
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442. Pssm-ID: 464251 [Multi-domain] Cd Length: 36 Bit Score: 43.39 E-value: 3.36e-06
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EGF_CA | cd00054 | Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ... |
224-269 | 1.17e-05 | ||
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements. Pssm-ID: 238011 Cd Length: 38 Bit Score: 42.24 E-value: 1.17e-05
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EGF | cd00053 | Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ... |
139-170 | 2.43e-05 | ||
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium. Pssm-ID: 238010 Cd Length: 36 Bit Score: 41.31 E-value: 2.43e-05
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EGF_CA | smart00179 | Calcium-binding EGF-like domain; |
270-304 | 2.69e-05 | ||
Calcium-binding EGF-like domain; Pssm-ID: 214542 [Multi-domain] Cd Length: 39 Bit Score: 41.08 E-value: 2.69e-05
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hEGF | pfam12661 | Human growth factor-like EGF; hEGF, or human growth factor-like EGF, domains have six ... |
145-165 | 1.16e-04 | ||
Human growth factor-like EGF; hEGF, or human growth factor-like EGF, domains have six conserved residues disulfide-bonded into the characteriztic 'ababcc' pattern. They are involved in growth and proliferation of cells, in proteins of the Notch/Delta pathway, neurogulin and selectins. hEGFs are also found in mosaic proteins with four-disulfide laminin EGFs such as aggrecan and perlecan. The core fold of the EGF domain consists of two small beta-hairpins packed against each other. Two major structural variants have been identified based on the structural context of the C-terminal Cys residue of disulfide 'c' in the C-terminal hairpin: hEGFs and cEGFs. In hEGFs the C-terminal thiol resides in the beta-turn, resulting in shorter loop-lengths between the Cys residues of disulfide 'c', typically C[8-9]XC. These shorter loop-lengths are also typical of the four-disulfide EGF domains, laminin ad integrin. Tandem hEGF domains have six linking residues between terminal cysteines of adjacent domains. hEGF domains may or may not bind calcium in the linker region. hEGF domains with the consensus motif CXD4X[F,Y]XCXC are hydroxylated exclusively in the Asp residue. Pssm-ID: 463660 Cd Length: 22 Bit Score: 38.85 E-value: 1.16e-04
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cEGF | pfam12662 | Complement Clr-like EGF-like; cEGF, or complement Clr-like EGF, domains have six conserved ... |
252-273 | 1.32e-04 | ||
Complement Clr-like EGF-like; cEGF, or complement Clr-like EGF, domains have six conserved cysteine residues disulfide-bonded into the characteriztic pattern 'ababcc'. They are found in blood coagulation proteins such as fibrillin, Clr and Cls, thrombomodulin, and the LDL receptor. The core fold of the EGF domain consists of two small beta-hairpins packed against each other. Two major structural variants have been identified based on the structural context of the C-terminal cysteine residue of disulfide 'c' in the C-terminal hairpin: hEGFs and cEGFs. In cEGFs the C-terminal thiol resides on the C-terminal beta-sheet, resulting in long loop-lengths between the cysteine residues of disulfide 'c', typically C[10+]XC. These longer loop-lengths may have arisen by selective cysteine loss from a four-disulfide EGF template such as laminin or integrin. Tandem cEGF domains have five linking residues between terminal cysteines of adjacent domains. cEGF domains may or may not bind calcium in the linker region. cEGF domains with the consensus motif CXN4X[F,Y]XCXC are hydroxylated exclusively on the asparagine residue. Pssm-ID: 463661 Cd Length: 22 Bit Score: 38.93 E-value: 1.32e-04
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EGF_CA | cd00054 | Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ... |
270-304 | 5.26e-04 | ||
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements. Pssm-ID: 238011 Cd Length: 38 Bit Score: 37.23 E-value: 5.26e-04
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PHA02817 | PHA02817 | EEV Host range protein; Provisional |
82-134 | 6.45e-04 | ||
EEV Host range protein; Provisional Pssm-ID: 165167 [Multi-domain] Cd Length: 225 Bit Score: 41.08 E-value: 6.45e-04
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vWA_Matrilin | cd01475 | VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and ... |
220-267 | 1.55e-03 | ||
VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and matrix-matrix interactions thereby providing tissue integrity. Some members of the matrilin family are expressed specifically in developing cartilage rudiments. The matrilin family consists of at least four members. All the members of the matrilin family contain VWA domains, EGF-like domains and a heptad repeat coiled-coiled domain at the carboxy terminus which is responsible for the oligomerization of the matrilins. The VWA domains have been shown to be essential for matrilin network formation by interacting with matrix ligands. Pssm-ID: 238752 [Multi-domain] Cd Length: 224 Bit Score: 40.06 E-value: 1.55e-03
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PHA02927 | PHA02927 | secreted complement-binding protein; Provisional |
93-134 | 1.96e-03 | ||
secreted complement-binding protein; Provisional Pssm-ID: 222943 [Multi-domain] Cd Length: 263 Bit Score: 40.02 E-value: 1.96e-03
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Blast search parameters | ||||
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