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pyruvate dehydrogenase (acetyl-transferring) kinase isozyme 1, mitochondrial isoform X7 [Homo sapiens]
alpha-ketoacid dehydrogenase kinase family protein( domain architecture ID 13768662)
alpha-ketoacid dehydrogenase kinase family protein similar to branched-chain alpha-ketoacid dehydrogenase kinase (BCDHK), which is part of the mitochondrial protein kinases family and is a regulator of the valine, leucine, and isoleucine catabolic pathways; contains a C-terminal histidine kinase-like ATPase domain
List of domain hits
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Name | Accession | Description | Interval | E-value | ||||
BCDHK_Adom3 | pfam10436 | Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase; Catabolism and synthesis of ... |
56-220 | 3.89e-65 | ||||
Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase; Catabolism and synthesis of leucine, isoleucine and valine are finely balanced, allowing the body to make the most of dietary input but removing excesses to prevent toxic build-up of their corresponding keto-acids. This is the butyryl-CoA dehydrogenase, subunit A domain 3, a largely alpha-helical bundle of the enzyme BCDHK. This enzyme is the regulator of the dehydrogenase complex that breaks branched-chain amino-acids down, by phosphorylating and thereby inactivating it when synthesis is required. The domain is associated with family HATPase_c pfam02518 which is towards the C-terminal. : Pssm-ID: 463093 Cd Length: 158 Bit Score: 200.04 E-value: 3.89e-65
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HATPase super family | cl00075 | Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ... |
224-259 | 6.76e-06 | ||||
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ATPase (HATPase) domains of several ATP-binding proteins such as histidine kinase, DNA gyrase B, topoisomerases, heat shock protein 90 (HSP90), phytochrome-like ATPases and DNA mismatch repair proteins. Domains belonging to this superfamily are also referred to as GHKL (gyrase, heat-shock protein 90, histidine kinase, MutL) ATPase domains. The actual alignment was detected with superfamily member cd16929: Pssm-ID: 469604 [Multi-domain] Cd Length: 169 Bit Score: 45.02 E-value: 6.76e-06
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Name | Accession | Description | Interval | E-value | ||||
BCDHK_Adom3 | pfam10436 | Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase; Catabolism and synthesis of ... |
56-220 | 3.89e-65 | ||||
Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase; Catabolism and synthesis of leucine, isoleucine and valine are finely balanced, allowing the body to make the most of dietary input but removing excesses to prevent toxic build-up of their corresponding keto-acids. This is the butyryl-CoA dehydrogenase, subunit A domain 3, a largely alpha-helical bundle of the enzyme BCDHK. This enzyme is the regulator of the dehydrogenase complex that breaks branched-chain amino-acids down, by phosphorylating and thereby inactivating it when synthesis is required. The domain is associated with family HATPase_c pfam02518 which is towards the C-terminal. Pssm-ID: 463093 Cd Length: 158 Bit Score: 200.04 E-value: 3.89e-65
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HATPase_PDK-like | cd16929 | Histidine kinase-like ATPase domain of pyruvate dehydrogenase kinase, branched-chain ... |
224-259 | 6.76e-06 | ||||
Histidine kinase-like ATPase domain of pyruvate dehydrogenase kinase, branched-chain alpha-ketoacid dehydrogenase kinase and related domains; This family includes the histidine kinase-like ATPase (HATPase) domains of all four PDK isoforms (pyruvate dehydrogenase kinases 1-4) that have been described in mammals, and other PDKs including Saccharomyces Pkp1p and Pkp2p. PDKs and phosphatases tightly regulate the mitochondrial pyruvate dehydrogenase complex (PDC) by reversible phosphorylation. PDC catalyzes the oxidative decarboxylation of pyruvate to acetyl-CoA, connecting glycolysis and the TCA acid cycle. Also included in this family is mammalian branched-chain alpha-ketoacid dehydrogenase kinase (BDK), a mitochondrial protein kinase that phosphorylates a subunit of the branched-chain a-ketoacid dehydrogenase (BCKD) complex, which catalyzes the oxidative decarboxylation of branched-chain alpha-ketoacids derived from leucine, isoleucine, and valine, a rate-limiting step in the oxidative degradation of these branched-chain amino acids. Pssm-ID: 340406 [Multi-domain] Cd Length: 169 Bit Score: 45.02 E-value: 6.76e-06
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Name | Accession | Description | Interval | E-value | ||||
BCDHK_Adom3 | pfam10436 | Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase; Catabolism and synthesis of ... |
56-220 | 3.89e-65 | ||||
Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase; Catabolism and synthesis of leucine, isoleucine and valine are finely balanced, allowing the body to make the most of dietary input but removing excesses to prevent toxic build-up of their corresponding keto-acids. This is the butyryl-CoA dehydrogenase, subunit A domain 3, a largely alpha-helical bundle of the enzyme BCDHK. This enzyme is the regulator of the dehydrogenase complex that breaks branched-chain amino-acids down, by phosphorylating and thereby inactivating it when synthesis is required. The domain is associated with family HATPase_c pfam02518 which is towards the C-terminal. Pssm-ID: 463093 Cd Length: 158 Bit Score: 200.04 E-value: 3.89e-65
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HATPase_PDK-like | cd16929 | Histidine kinase-like ATPase domain of pyruvate dehydrogenase kinase, branched-chain ... |
224-259 | 6.76e-06 | ||||
Histidine kinase-like ATPase domain of pyruvate dehydrogenase kinase, branched-chain alpha-ketoacid dehydrogenase kinase and related domains; This family includes the histidine kinase-like ATPase (HATPase) domains of all four PDK isoforms (pyruvate dehydrogenase kinases 1-4) that have been described in mammals, and other PDKs including Saccharomyces Pkp1p and Pkp2p. PDKs and phosphatases tightly regulate the mitochondrial pyruvate dehydrogenase complex (PDC) by reversible phosphorylation. PDC catalyzes the oxidative decarboxylation of pyruvate to acetyl-CoA, connecting glycolysis and the TCA acid cycle. Also included in this family is mammalian branched-chain alpha-ketoacid dehydrogenase kinase (BDK), a mitochondrial protein kinase that phosphorylates a subunit of the branched-chain a-ketoacid dehydrogenase (BCKD) complex, which catalyzes the oxidative decarboxylation of branched-chain alpha-ketoacids derived from leucine, isoleucine, and valine, a rate-limiting step in the oxidative degradation of these branched-chain amino acids. Pssm-ID: 340406 [Multi-domain] Cd Length: 169 Bit Score: 45.02 E-value: 6.76e-06
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Blast search parameters | ||||
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