alsin isoform X5 [Homo sapiens]
List of domain hits
Name | Accession | Description | Interval | E-value | ||||
PH_alsin | cd13269 | Alsin Pleckstrin homology (PH) domain; The ALS2 gene encodes alsin, a GEF, that has dual ... |
905-1010 | 4.20e-64 | ||||
Alsin Pleckstrin homology (PH) domain; The ALS2 gene encodes alsin, a GEF, that has dual specificity for Rac1 and Rab5 GTPases. Alsin mutations in the form of truncated proteins are responsible for motor function disorders including juvenile-onset amyotrophic lateral sclerosis, familial juvenile primary lateral sclerosis, and infantile-onset ascending hereditary spastic paralysis. The alsin protein is widely expressed in the developing CNS including neurons of the cerebral cortex, brain stem, spinal cord, and cerebellum. Alsin contains a regulator of chromosome condensation 1 (RCC1) domain, a Rho guanine nucleotide exchanging factor (RhoGEF) domain, a PH domain, a Membrane Occupation and Recognition Nexus (MORN), a vacuolar protein sorting 9 (Vps9) domain, and a Dbl homology (DH) domain. Alsin interacts with Rab5 through its Vps9 domain and through this interaction modulates early endosome fusion and trafficking. The GEF activity of alsin towards Rab5 is regulated by Rac1 function. The GEF activity of alsin for Rac1 occurs via its DH domain and this interaction plays a role in promoting spinal motor neuron survival via multiple Rac-dependent signaling pathways. PH domains have diverse functions, but in general are involved in targeting proteins to the appropriate cellular location or in the interaction with a binding partner. They share little sequence conservation, but all have a common fold, which is electrostatically polarized. Less than 10% of PH domains bind phosphoinositide phosphates (PIPs) with high affinity and specificity. PH domains are distinguished from other PIP-binding domains by their specific high-affinity binding to PIPs with two vicinal phosphate groups: PtdIns(3,4)P2, PtdIns(4,5)P2 or PtdIns(3,4,5)P3 which results in targeting some PH domain proteins to the plasma membrane. A few display strong specificity in lipid binding. Any specificity is usually determined by loop regions or insertions in the N-terminus of the domain, which are not conserved across all PH domains. PH domains are found in cellular signaling proteins such as serine/threonine kinase, tyrosine kinases, regulators of G-proteins, endocytotic GTPases, adaptors, as well as cytoskeletal associated molecules and in lipid associated enzymes. : Pssm-ID: 241423 Cd Length: 106 Bit Score: 212.25 E-value: 4.20e-64
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COG4642 | COG4642 | Uncharacterized conserved protein [Function unknown]; |
1049-1227 | 4.56e-34 | ||||
Uncharacterized conserved protein [Function unknown]; : Pssm-ID: 443680 [Multi-domain] Cd Length: 271 Bit Score: 132.39 E-value: 4.56e-34
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ATS1 | COG5184 | Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ... |
39-219 | 4.50e-26 | ||||
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]; : Pssm-ID: 444065 [Multi-domain] Cd Length: 343 Bit Score: 111.22 E-value: 4.50e-26
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ATS1 super family | cl34932 | Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ... |
527-683 | 6.12e-18 | ||||
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]; The actual alignment was detected with superfamily member COG5184: Pssm-ID: 444065 [Multi-domain] Cd Length: 343 Bit Score: 86.95 E-value: 6.12e-18
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RhoGEF super family | cl02571 | Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous ... |
695-879 | 2.19e-07 | ||||
Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains. The actual alignment was detected with superfamily member cd00160: Pssm-ID: 470622 [Multi-domain] Cd Length: 181 Bit Score: 52.30 E-value: 2.19e-07
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Name | Accession | Description | Interval | E-value | ||||
PH_alsin | cd13269 | Alsin Pleckstrin homology (PH) domain; The ALS2 gene encodes alsin, a GEF, that has dual ... |
905-1010 | 4.20e-64 | ||||
Alsin Pleckstrin homology (PH) domain; The ALS2 gene encodes alsin, a GEF, that has dual specificity for Rac1 and Rab5 GTPases. Alsin mutations in the form of truncated proteins are responsible for motor function disorders including juvenile-onset amyotrophic lateral sclerosis, familial juvenile primary lateral sclerosis, and infantile-onset ascending hereditary spastic paralysis. The alsin protein is widely expressed in the developing CNS including neurons of the cerebral cortex, brain stem, spinal cord, and cerebellum. Alsin contains a regulator of chromosome condensation 1 (RCC1) domain, a Rho guanine nucleotide exchanging factor (RhoGEF) domain, a PH domain, a Membrane Occupation and Recognition Nexus (MORN), a vacuolar protein sorting 9 (Vps9) domain, and a Dbl homology (DH) domain. Alsin interacts with Rab5 through its Vps9 domain and through this interaction modulates early endosome fusion and trafficking. The GEF activity of alsin towards Rab5 is regulated by Rac1 function. The GEF activity of alsin for Rac1 occurs via its DH domain and this interaction plays a role in promoting spinal motor neuron survival via multiple Rac-dependent signaling pathways. PH domains have diverse functions, but in general are involved in targeting proteins to the appropriate cellular location or in the interaction with a binding partner. They share little sequence conservation, but all have a common fold, which is electrostatically polarized. Less than 10% of PH domains bind phosphoinositide phosphates (PIPs) with high affinity and specificity. PH domains are distinguished from other PIP-binding domains by their specific high-affinity binding to PIPs with two vicinal phosphate groups: PtdIns(3,4)P2, PtdIns(4,5)P2 or PtdIns(3,4,5)P3 which results in targeting some PH domain proteins to the plasma membrane. A few display strong specificity in lipid binding. Any specificity is usually determined by loop regions or insertions in the N-terminus of the domain, which are not conserved across all PH domains. PH domains are found in cellular signaling proteins such as serine/threonine kinase, tyrosine kinases, regulators of G-proteins, endocytotic GTPases, adaptors, as well as cytoskeletal associated molecules and in lipid associated enzymes. Pssm-ID: 241423 Cd Length: 106 Bit Score: 212.25 E-value: 4.20e-64
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COG4642 | COG4642 | Uncharacterized conserved protein [Function unknown]; |
1049-1227 | 4.56e-34 | ||||
Uncharacterized conserved protein [Function unknown]; Pssm-ID: 443680 [Multi-domain] Cd Length: 271 Bit Score: 132.39 E-value: 4.56e-34
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ATS1 | COG5184 | Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ... |
39-219 | 4.50e-26 | ||||
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]; Pssm-ID: 444065 [Multi-domain] Cd Length: 343 Bit Score: 111.22 E-value: 4.50e-26
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PLN03185 | PLN03185 | phosphatidylinositol phosphate kinase; Provisional |
1048-1166 | 2.39e-19 | ||||
phosphatidylinositol phosphate kinase; Provisional Pssm-ID: 215619 [Multi-domain] Cd Length: 765 Bit Score: 94.13 E-value: 2.39e-19
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ATS1 | COG5184 | Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ... |
527-683 | 6.12e-18 | ||||
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]; Pssm-ID: 444065 [Multi-domain] Cd Length: 343 Bit Score: 86.95 E-value: 6.12e-18
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RCC1 | pfam00415 | Regulator of chromosome condensation (RCC1) repeat; |
527-574 | 1.03e-11 | ||||
Regulator of chromosome condensation (RCC1) repeat; Pssm-ID: 395335 [Multi-domain] Cd Length: 50 Bit Score: 60.61 E-value: 1.03e-11
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RCC1 | pfam00415 | Regulator of chromosome condensation (RCC1) repeat; |
170-216 | 7.17e-09 | ||||
Regulator of chromosome condensation (RCC1) repeat; Pssm-ID: 395335 [Multi-domain] Cd Length: 50 Bit Score: 52.90 E-value: 7.17e-09
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RhoGEF | cd00160 | Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous ... |
695-879 | 2.19e-07 | ||||
Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains. Pssm-ID: 238091 [Multi-domain] Cd Length: 181 Bit Score: 52.30 E-value: 2.19e-07
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RhoGEF | smart00325 | Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Guanine nucleotide exchange ... |
695-879 | 5.53e-07 | ||||
Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains. Improved coverage. Pssm-ID: 214619 [Multi-domain] Cd Length: 180 Bit Score: 51.15 E-value: 5.53e-07
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MORN | pfam02493 | MORN repeat; The MORN (Membrane Occupation and Recognition Nexus) repeat is found in multiple ... |
1100-1122 | 6.94e-05 | ||||
MORN repeat; The MORN (Membrane Occupation and Recognition Nexus) repeat is found in multiple copies in several proteins including junctophilins (See Takeshima et al. Mol. Cell 2000;6:11-22). A MORN-repeat protein has been identified in the parasite Toxoplasma gondiis a dynamic component of cell division apparatus in Toxoplasma gondii. It has been hypothesized to functions as a linker protein between certain membrane regions and the parasite's cytoskeleton. Pssm-ID: 308220 [Multi-domain] Cd Length: 23 Bit Score: 40.85 E-value: 6.94e-05
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MORN | smart00698 | Possible plasma membrane-binding motif in junctophilins, PIP-5-kinases and protein kinases; |
1098-1118 | 1.25e-04 | ||||
Possible plasma membrane-binding motif in junctophilins, PIP-5-kinases and protein kinases; Pssm-ID: 197832 [Multi-domain] Cd Length: 22 Bit Score: 40.02 E-value: 1.25e-04
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PH | smart00233 | Pleckstrin homology domain; Domain commonly found in eukaryotic signalling proteins. The ... |
935-1005 | 1.45e-03 | ||||
Pleckstrin homology domain; Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted domains (such as in PLC gamma, syntrophins) and to be inserted within other domains. Mutations in Brutons tyrosine kinase (Btk) within its PH domain cause X-linked agammaglobulinaemia (XLA) in patients. Point mutations cluster into the positively charged end of the molecule around the predicted binding site for phosphatidylinositol lipids. Pssm-ID: 214574 [Multi-domain] Cd Length: 102 Bit Score: 39.45 E-value: 1.45e-03
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RhoGEF | pfam00621 | RhoGEF domain; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases Also called ... |
695-871 | 5.76e-03 | ||||
RhoGEF domain; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases Also called Dbl-homologous (DH) domain. It appears that pfam00169 domains invariably occur C-terminal to RhoGEF/DH domains. Pssm-ID: 459876 [Multi-domain] Cd Length: 176 Bit Score: 39.21 E-value: 5.76e-03
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Name | Accession | Description | Interval | E-value | ||||
PH_alsin | cd13269 | Alsin Pleckstrin homology (PH) domain; The ALS2 gene encodes alsin, a GEF, that has dual ... |
905-1010 | 4.20e-64 | ||||
Alsin Pleckstrin homology (PH) domain; The ALS2 gene encodes alsin, a GEF, that has dual specificity for Rac1 and Rab5 GTPases. Alsin mutations in the form of truncated proteins are responsible for motor function disorders including juvenile-onset amyotrophic lateral sclerosis, familial juvenile primary lateral sclerosis, and infantile-onset ascending hereditary spastic paralysis. The alsin protein is widely expressed in the developing CNS including neurons of the cerebral cortex, brain stem, spinal cord, and cerebellum. Alsin contains a regulator of chromosome condensation 1 (RCC1) domain, a Rho guanine nucleotide exchanging factor (RhoGEF) domain, a PH domain, a Membrane Occupation and Recognition Nexus (MORN), a vacuolar protein sorting 9 (Vps9) domain, and a Dbl homology (DH) domain. Alsin interacts with Rab5 through its Vps9 domain and through this interaction modulates early endosome fusion and trafficking. The GEF activity of alsin towards Rab5 is regulated by Rac1 function. The GEF activity of alsin for Rac1 occurs via its DH domain and this interaction plays a role in promoting spinal motor neuron survival via multiple Rac-dependent signaling pathways. PH domains have diverse functions, but in general are involved in targeting proteins to the appropriate cellular location or in the interaction with a binding partner. They share little sequence conservation, but all have a common fold, which is electrostatically polarized. Less than 10% of PH domains bind phosphoinositide phosphates (PIPs) with high affinity and specificity. PH domains are distinguished from other PIP-binding domains by their specific high-affinity binding to PIPs with two vicinal phosphate groups: PtdIns(3,4)P2, PtdIns(4,5)P2 or PtdIns(3,4,5)P3 which results in targeting some PH domain proteins to the plasma membrane. A few display strong specificity in lipid binding. Any specificity is usually determined by loop regions or insertions in the N-terminus of the domain, which are not conserved across all PH domains. PH domains are found in cellular signaling proteins such as serine/threonine kinase, tyrosine kinases, regulators of G-proteins, endocytotic GTPases, adaptors, as well as cytoskeletal associated molecules and in lipid associated enzymes. Pssm-ID: 241423 Cd Length: 106 Bit Score: 212.25 E-value: 4.20e-64
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COG4642 | COG4642 | Uncharacterized conserved protein [Function unknown]; |
1049-1227 | 4.56e-34 | ||||
Uncharacterized conserved protein [Function unknown]; Pssm-ID: 443680 [Multi-domain] Cd Length: 271 Bit Score: 132.39 E-value: 4.56e-34
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COG4642 | COG4642 | Uncharacterized conserved protein [Function unknown]; |
1047-1181 | 4.24e-32 | ||||
Uncharacterized conserved protein [Function unknown]; Pssm-ID: 443680 [Multi-domain] Cd Length: 271 Bit Score: 126.61 E-value: 4.24e-32
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COG4642 | COG4642 | Uncharacterized conserved protein [Function unknown]; |
1035-1157 | 5.86e-30 | ||||
Uncharacterized conserved protein [Function unknown]; Pssm-ID: 443680 [Multi-domain] Cd Length: 271 Bit Score: 120.45 E-value: 5.86e-30
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ATS1 | COG5184 | Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ... |
39-219 | 4.50e-26 | ||||
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]; Pssm-ID: 444065 [Multi-domain] Cd Length: 343 Bit Score: 111.22 E-value: 4.50e-26
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ATS1 | COG5184 | Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ... |
31-216 | 2.84e-23 | ||||
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]; Pssm-ID: 444065 [Multi-domain] Cd Length: 343 Bit Score: 102.75 E-value: 2.84e-23
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ATS1 | COG5184 | Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ... |
31-219 | 9.34e-22 | ||||
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]; Pssm-ID: 444065 [Multi-domain] Cd Length: 343 Bit Score: 98.13 E-value: 9.34e-22
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COG4642 | COG4642 | Uncharacterized conserved protein [Function unknown]; |
1034-1234 | 1.31e-21 | ||||
Uncharacterized conserved protein [Function unknown]; Pssm-ID: 443680 [Multi-domain] Cd Length: 271 Bit Score: 96.18 E-value: 1.31e-21
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ATS1 | COG5184 | Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ... |
45-216 | 2.62e-20 | ||||
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]; Pssm-ID: 444065 [Multi-domain] Cd Length: 343 Bit Score: 93.89 E-value: 2.62e-20
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PLN03185 | PLN03185 | phosphatidylinositol phosphate kinase; Provisional |
1048-1166 | 2.39e-19 | ||||
phosphatidylinositol phosphate kinase; Provisional Pssm-ID: 215619 [Multi-domain] Cd Length: 765 Bit Score: 94.13 E-value: 2.39e-19
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PLN03185 | PLN03185 | phosphatidylinositol phosphate kinase; Provisional |
1048-1202 | 2.86e-19 | ||||
phosphatidylinositol phosphate kinase; Provisional Pssm-ID: 215619 [Multi-domain] Cd Length: 765 Bit Score: 94.13 E-value: 2.86e-19
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ATS1 | COG5184 | Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ... |
527-683 | 6.12e-18 | ||||
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]; Pssm-ID: 444065 [Multi-domain] Cd Length: 343 Bit Score: 86.95 E-value: 6.12e-18
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ATS1 | COG5184 | Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ... |
94-216 | 1.45e-17 | ||||
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]; Pssm-ID: 444065 [Multi-domain] Cd Length: 343 Bit Score: 85.80 E-value: 1.45e-17
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ATS1 | COG5184 | Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ... |
31-189 | 1.54e-17 | ||||
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]; Pssm-ID: 444065 [Multi-domain] Cd Length: 343 Bit Score: 85.80 E-value: 1.54e-17
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ATS1 | COG5184 | Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ... |
527-628 | 4.03e-17 | ||||
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]; Pssm-ID: 444065 [Multi-domain] Cd Length: 343 Bit Score: 84.26 E-value: 4.03e-17
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ATS1 | COG5184 | Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ... |
528-628 | 5.99e-17 | ||||
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]; Pssm-ID: 444065 [Multi-domain] Cd Length: 343 Bit Score: 83.87 E-value: 5.99e-17
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ATS1 | COG5184 | Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ... |
527-625 | 1.10e-16 | ||||
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]; Pssm-ID: 444065 [Multi-domain] Cd Length: 343 Bit Score: 83.10 E-value: 1.10e-16
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PLN03185 | PLN03185 | phosphatidylinositol phosphate kinase; Provisional |
1049-1238 | 1.55e-16 | ||||
phosphatidylinositol phosphate kinase; Provisional Pssm-ID: 215619 [Multi-domain] Cd Length: 765 Bit Score: 85.27 E-value: 1.55e-16
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PLN03185 | PLN03185 | phosphatidylinositol phosphate kinase; Provisional |
1062-1227 | 1.20e-14 | ||||
phosphatidylinositol phosphate kinase; Provisional Pssm-ID: 215619 [Multi-domain] Cd Length: 765 Bit Score: 79.11 E-value: 1.20e-14
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ATS1 | COG5184 | Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ... |
528-592 | 1.82e-13 | ||||
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]; Pssm-ID: 444065 [Multi-domain] Cd Length: 343 Bit Score: 73.09 E-value: 1.82e-13
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RCC1 | pfam00415 | Regulator of chromosome condensation (RCC1) repeat; |
527-574 | 1.03e-11 | ||||
Regulator of chromosome condensation (RCC1) repeat; Pssm-ID: 395335 [Multi-domain] Cd Length: 50 Bit Score: 60.61 E-value: 1.03e-11
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PH_Phafin2-like | cd01218 | Phafin2 (also called EAPF, FLJ13187, ZFYVE18 or PLEKHF2) Pleckstrin Homology (PH) domain; ... |
935-1003 | 8.04e-10 | ||||
Phafin2 (also called EAPF, FLJ13187, ZFYVE18 or PLEKHF2) Pleckstrin Homology (PH) domain; Phafin2 is differentially expressed in the liver cancer cell and regulates the structure and function of the endosomes through Rab5-dependent processes. Phafin2 modulates the cell's response to extracellular stimulation by modulating the receptor density on the cell surface. Phafin2 contains a PH domain and a FYVE domain. PH domains have diverse functions, but in general are involved in targeting proteins to the appropriate cellular location or in the interaction with a binding partner. They share little sequence conservation, but all have a common fold, which is electrostatically polarized. Less than 10% of PH domains bind phosphoinositide phosphates (PIPs) with high affinity and specificity. PH domains are distinguished from other PIP-binding domains by their specific high-affinity binding to PIPs with two vicinal phosphate groups: PtdIns(3,4)P2, PtdIns(4,5)P2 or PtdIns(3,4,5)P3 which results in targeting some PH domain proteins to the plasma membrane. A few display strong specificity in lipid binding. Any specificity is usually determined by loop regions or insertions in the N-terminus of the domain, which are not conserved across all PH domains. PH domains are found in cellular signaling proteins such as serine/threonine kinase, tyrosine kinases, regulators of G-proteins, endocytotic GTPases, adaptors, as well as cytoskeletal associated molecules and in lipid associated enzymes. Pssm-ID: 269927 [Multi-domain] Cd Length: 123 Bit Score: 57.65 E-value: 8.04e-10
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RCC1 | pfam00415 | Regulator of chromosome condensation (RCC1) repeat; |
579-625 | 6.07e-09 | ||||
Regulator of chromosome condensation (RCC1) repeat; Pssm-ID: 395335 [Multi-domain] Cd Length: 50 Bit Score: 52.90 E-value: 6.07e-09
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RCC1 | pfam00415 | Regulator of chromosome condensation (RCC1) repeat; |
170-216 | 7.17e-09 | ||||
Regulator of chromosome condensation (RCC1) repeat; Pssm-ID: 395335 [Multi-domain] Cd Length: 50 Bit Score: 52.90 E-value: 7.17e-09
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ATS1 | COG5184 | Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ... |
562-625 | 9.65e-09 | ||||
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]; Pssm-ID: 444065 [Multi-domain] Cd Length: 343 Bit Score: 58.83 E-value: 9.65e-09
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PH1_FGD5_FGD6 | cd13389 | FYVE, RhoGEF and PH domain containing/faciogenital dysplasia proteins 5 and 6, N-terminal ... |
936-1004 | 7.74e-08 | ||||
FYVE, RhoGEF and PH domain containing/faciogenital dysplasia proteins 5 and 6, N-terminal Pleckstrin Homology (PH) domain; FGD5 regulates promotes angiogenesis of vascular endothelial growth factor (VEGF) in vascular endothelial cells, including network formation, permeability, directional movement, and proliferation. The specific function of FGD6 is unknown. In general, FGDs have a RhoGEF (DH) domain, followed by a PH domain, a FYVE domain and a C-terminal PH domain. All FGDs are guanine nucleotide exchange factors that activate the Rho GTPase Cdc42, an important regulator of membrane trafficking. The RhoGEF domain is responsible for GEF catalytic activity, while the PH domain is involved in intracellular targeting of the DH domain. PH domains have diverse functions, but in general are involved in targeting proteins to the appropriate cellular location or in the interaction with a binding partner. They share little sequence conservation, but all have a common fold, which is electrostatically polarized. Less than 10% of PH domains bind phosphoinositide phosphates (PIPs) with high affinity and specificity. PH domains are distinguished from other PIP-binding domains by their specific high-affinity binding to PIPs with two vicinal phosphate groups: PtdIns(3,4)P2, PtdIns(4,5)P2 or PtdIns(3,4,5)P3 which results in targeting some PH domain proteins to the plasma membrane. A few display strong specificity in lipid binding. Any specificity is usually determined by loop regions or insertions in the N-terminus of the domain, which are not conserved across all PH domains. PH domains are found in cellular signaling proteins such as serine/threonine kinase, tyrosine kinases, regulators of G-proteins, endocytotic GTPases, adaptors, as well as cytoskeletal associated molecules and in lipid associated enzymes. Pssm-ID: 275424 Cd Length: 124 Bit Score: 52.27 E-value: 7.74e-08
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RCC1_2 | pfam13540 | Regulator of chromosome condensation (RCC1) repeat; |
561-590 | 1.68e-07 | ||||
Regulator of chromosome condensation (RCC1) repeat; Pssm-ID: 463914 [Multi-domain] Cd Length: 30 Bit Score: 48.19 E-value: 1.68e-07
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RhoGEF | cd00160 | Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous ... |
695-879 | 2.19e-07 | ||||
Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains. Pssm-ID: 238091 [Multi-domain] Cd Length: 181 Bit Score: 52.30 E-value: 2.19e-07
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PH1_FARP1-like | cd01220 | FERM, RhoGEF and pleckstrin domain-containing protein 1 and related proteins Pleckstrin ... |
936-1007 | 2.89e-07 | ||||
FERM, RhoGEF and pleckstrin domain-containing protein 1 and related proteins Pleckstrin Homology (PH) domain, repeat 1; Members here include FARP1 (also called Chondrocyte-derived ezrin-like protein; PH domain-containing family C member 2), FARP2 (also called FIR/FERM domain including RhoGEF; FGD1-related Cdc42-GEF/FRG), and FARP6 (also called Zinc finger FYVE domain-containing protein 24). They are members of the Dbl family guanine nucleotide exchange factors (GEFs) which are upstream positive regulators of Rho GTPases. Little is known about FARP1 and FARP6, though FARP1 has increased expression in differentiated chondrocytes. FARP2 is thought to regulate neurite remodeling by mediating the signaling pathways from membrane proteins to Rac. It is found in brain, lung, and testis, as well as embryonic hippocampal and cortical neurons. FARP1 and FARP2 are composed of a N-terminal FERM domain, a proline-rich (PR) domain, Dbl-homology (DH), and two C-terminal PH domains. FARP6 is composed of Dbl-homology (DH), and two C-terminal PH domains separated by a FYVE domain. This hierarchy contains the first PH repeat. PH domains have diverse functions, but in general are involved in targeting proteins to the appropriate cellular location or in the interaction with a binding partner. They share little sequence conservation, but all have a common fold, which is electrostatically polarized. Less than 10% of PH domains bind phosphoinositide phosphates (PIPs) with high affinity and specificity. PH domains are distinguished from other PIP-binding domains by their specific high-affinity binding to PIPs with two vicinal phosphate groups: PtdIns(3,4)P2, PtdIns(4,5)P2 or PtdIns(3,4,5)P3 which results in targeting some PH domain proteins to the plasma membrane. A few display strong specificity in lipid binding. Any specificity is usually determined by loop regions or insertions in the N-terminus of the domain, which are not conserved across all PH domains. PH domains are found in cellular signaling proteins such as serine/threonine kinase, tyrosine kinases, regulators of G-proteins, endocytotic GTPases, adaptors, as well as cytoskeletal associated molecules and in lipid associated enzymes. Pssm-ID: 269928 Cd Length: 109 Bit Score: 50.01 E-value: 2.89e-07
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RhoGEF | smart00325 | Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Guanine nucleotide exchange ... |
695-879 | 5.53e-07 | ||||
Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains. Improved coverage. Pssm-ID: 214619 [Multi-domain] Cd Length: 180 Bit Score: 51.15 E-value: 5.53e-07
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PH1_FGD6 | cd15793 | FYVE, RhoGEF and PH domain containing/faciogenital dysplasia protein 6, N-terminal Pleckstrin ... |
936-1006 | 5.98e-06 | ||||
FYVE, RhoGEF and PH domain containing/faciogenital dysplasia protein 6, N-terminal Pleckstrin Homology (PH) domain; FGD5 regulates promotes angiogenesis of vascular endothelial growth factor (VEGF) in vascular endothelial cells, including network formation, permeability, directional movement, and proliferation. The specific function of FGD6 is unknown. In general, FGDs have a RhoGEF (DH) domain, followed by a PH domain, a FYVE domain and a C-terminal PH domain. All FGDs are guanine nucleotide exchange factors that activate the Rho GTPase Cdc42, an important regulator of membrane trafficking. The RhoGEF domain is responsible for GEF catalytic activity, while the PH domain is involved in intracellular targeting of the DH domain. PH domains have diverse functions, but in general are involved in targeting proteins to the appropriate cellular location or in the interaction with a binding partner. They share little sequence conservation, but all have a common fold, which is electrostatically polarized. Less than 10% of PH domains bind phosphoinositide phosphates (PIPs) with high affinity and specificity. PH domains are distinguished from other PIP-binding domains by their specific high-affinity binding to PIPs with two vicinal phosphate groups: PtdIns(3,4)P2, PtdIns(4,5)P2 or PtdIns(3,4,5)P3 which results in targeting some PH domain proteins to the plasma membrane. A few display strong specificity in lipid binding. Any specificity is usually determined by loop regions or insertions in the N-terminus of the domain, which are not conserved across all PH domains. PH domains are found in cellular signaling proteins such as serine/threonine kinase, tyrosine kinases, regulators of G-proteins, endocytotic GTPases, adaptors, as well as cytoskeletal associated molecules and in lipid associated enzymes. Pssm-ID: 275436 Cd Length: 123 Bit Score: 46.95 E-value: 5.98e-06
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RCC1_2 | pfam13540 | Regulator of chromosome condensation (RCC1) repeat; |
93-122 | 8.86e-06 | ||||
Regulator of chromosome condensation (RCC1) repeat; Pssm-ID: 463914 [Multi-domain] Cd Length: 30 Bit Score: 43.57 E-value: 8.86e-06
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PH_AtPH1 | cd13276 | Arabidopsis thaliana Pleckstrin homolog (PH) 1 (AtPH1) PH domain; AtPH1 is expressed in all ... |
935-1013 | 1.52e-05 | ||||
Arabidopsis thaliana Pleckstrin homolog (PH) 1 (AtPH1) PH domain; AtPH1 is expressed in all plant tissue and is proposed to be the plant homolog of human pleckstrin. Pleckstrin consists of two PH domains separated by a linker region, while AtPH has a single PH domain with a short N-terminal extension. AtPH1 binds PtdIns3P specifically and is thought to be an adaptor molecule since it has no obvious catalytic functions. PH domains have diverse functions, but in general are involved in targeting proteins to the appropriate cellular location or in the interaction with a binding partner. They share little sequence conservation, but all have a common fold, which is electrostatically polarized. Less than 10% of PH domains bind phosphoinositide phosphates (PIPs) with high affinity and specificity. PH domains are distinguished from other PIP-binding domains by their specific high-affinity binding to PIPs with two vicinal phosphate groups: PtdIns(3,4)P2, PtdIns(4,5)P2 or PtdIns(3,4,5)P3 which results in targeting some PH domain proteins to the plasma membrane. A few display strong specificity in lipid binding. Any specificity is usually determined by loop regions or insertions in the N-terminus of the domain, which are not conserved across all PH domains. PH domains are found in cellular signaling proteins such as serine/threonine kinase, tyrosine kinases, regulators of G-proteins, endocytotic GTPases, adaptors, as well as cytoskeletal associated molecules and in lipid associated enzymes. Pssm-ID: 270095 Cd Length: 106 Bit Score: 45.00 E-value: 1.52e-05
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YwqK | COG2849 | Antitoxin component YwqK of the YwqJK toxin-antitoxin module [Defense mechanisms]; |
1035-1145 | 3.76e-05 | ||||
Antitoxin component YwqK of the YwqJK toxin-antitoxin module [Defense mechanisms]; Pssm-ID: 442097 [Multi-domain] Cd Length: 163 Bit Score: 45.44 E-value: 3.76e-05
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MORN | pfam02493 | MORN repeat; The MORN (Membrane Occupation and Recognition Nexus) repeat is found in multiple ... |
1100-1122 | 6.94e-05 | ||||
MORN repeat; The MORN (Membrane Occupation and Recognition Nexus) repeat is found in multiple copies in several proteins including junctophilins (See Takeshima et al. Mol. Cell 2000;6:11-22). A MORN-repeat protein has been identified in the parasite Toxoplasma gondiis a dynamic component of cell division apparatus in Toxoplasma gondii. It has been hypothesized to functions as a linker protein between certain membrane regions and the parasite's cytoskeleton. Pssm-ID: 308220 [Multi-domain] Cd Length: 23 Bit Score: 40.85 E-value: 6.94e-05
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RCC1 | pfam00415 | Regulator of chromosome condensation (RCC1) repeat; |
109-165 | 6.96e-05 | ||||
Regulator of chromosome condensation (RCC1) repeat; Pssm-ID: 395335 [Multi-domain] Cd Length: 50 Bit Score: 41.35 E-value: 6.96e-05
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MORN | smart00698 | Possible plasma membrane-binding motif in junctophilins, PIP-5-kinases and protein kinases; |
1098-1118 | 1.25e-04 | ||||
Possible plasma membrane-binding motif in junctophilins, PIP-5-kinases and protein kinases; Pssm-ID: 197832 [Multi-domain] Cd Length: 22 Bit Score: 40.02 E-value: 1.25e-04
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MORN | pfam02493 | MORN repeat; The MORN (Membrane Occupation and Recognition Nexus) repeat is found in multiple ... |
1049-1069 | 1.69e-04 | ||||
MORN repeat; The MORN (Membrane Occupation and Recognition Nexus) repeat is found in multiple copies in several proteins including junctophilins (See Takeshima et al. Mol. Cell 2000;6:11-22). A MORN-repeat protein has been identified in the parasite Toxoplasma gondiis a dynamic component of cell division apparatus in Toxoplasma gondii. It has been hypothesized to functions as a linker protein between certain membrane regions and the parasite's cytoskeleton. Pssm-ID: 308220 [Multi-domain] Cd Length: 23 Bit Score: 39.70 E-value: 1.69e-04
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MORN | smart00698 | Possible plasma membrane-binding motif in junctophilins, PIP-5-kinases and protein kinases; |
1047-1068 | 2.68e-04 | ||||
Possible plasma membrane-binding motif in junctophilins, PIP-5-kinases and protein kinases; Pssm-ID: 197832 [Multi-domain] Cd Length: 22 Bit Score: 39.25 E-value: 2.68e-04
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PH | cd00821 | Pleckstrin homology (PH) domain; PH domains have diverse functions, but in general are ... |
935-1000 | 6.72e-04 | ||||
Pleckstrin homology (PH) domain; PH domains have diverse functions, but in general are involved in targeting proteins to the appropriate cellular location or in the interaction with a binding partner. They share little sequence conservation, but all have a common fold, which is electrostatically polarized. Less than 10% of PH domains bind phosphoinositide phosphates (PIPs) with high affinity and specificity. PH domains are distinguished from other PIP-binding domains by their specific high-affinity binding to PIPs with two vicinal phosphate groups: PtdIns(3,4)P2, PtdIns(4,5)P2 or PtdIns(3,4,5)P3 which results in targeting some PH domain proteins to the plasma membrane. A few display strong specificity in lipid binding. Any specificity is usually determined by loop regions or insertions in the N-terminus of the domain, which are not conserved across all PH domains. PH domains are found in cellular signaling proteins such as serine/threonine kinase, tyrosine kinases, regulators of G-proteins, endocytotic GTPases, adaptors, as well as cytoskeletal associated molecules and in lipid associated enzymes. Pssm-ID: 275388 [Multi-domain] Cd Length: 92 Bit Score: 40.22 E-value: 6.72e-04
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PH | smart00233 | Pleckstrin homology domain; Domain commonly found in eukaryotic signalling proteins. The ... |
935-1005 | 1.45e-03 | ||||
Pleckstrin homology domain; Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted domains (such as in PLC gamma, syntrophins) and to be inserted within other domains. Mutations in Brutons tyrosine kinase (Btk) within its PH domain cause X-linked agammaglobulinaemia (XLA) in patients. Point mutations cluster into the positively charged end of the molecule around the predicted binding site for phosphatidylinositol lipids. Pssm-ID: 214574 [Multi-domain] Cd Length: 102 Bit Score: 39.45 E-value: 1.45e-03
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RhoGEF | pfam00621 | RhoGEF domain; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases Also called ... |
695-871 | 5.76e-03 | ||||
RhoGEF domain; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases Also called Dbl-homologous (DH) domain. It appears that pfam00169 domains invariably occur C-terminal to RhoGEF/DH domains. Pssm-ID: 459876 [Multi-domain] Cd Length: 176 Bit Score: 39.21 E-value: 5.76e-03
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