NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|2462591981|ref|XP_054203544|]
View 

lysosomal dipeptide transporter MFSD1 isoform X3 [Homo sapiens]

Protein Classification

major facilitator superfamily domain-containing protein 1( domain architecture ID 13023811)

major facilitator superfamily domain-containing protein 1 (MFSD1) is also called smooth muscle cell-associated protein 4 (SMAP-4) in humans and is a putative solute carrier transporter affected by nutrient intake

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
MFS_MFSD1 cd17340
Major facilitator superfamily domain-containing protein 1; Human major facilitator superfamily ...
 49-388 0e+00

Major facilitator superfamily domain-containing protein 1; Human major facilitator superfamily domain-containing protein 1 (MFSD1) is also called smooth muscle cell-associated protein 4 (SMAP-4). The function of MFSD1 is still unknown. Its expression is affected by altered nutrient intake. During starvation, expression of MFSD1 is downregulated in anterior brain sections in mice while it is upregulated in the brainstem. In mice raised on high-fat diet, MFSD1 is specifically downregulated in brainstem and hypothalamus. MFSD1 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


:

Pssm-ID: 340898 [Multi-domain]  Cd Length: 394  Bit Score: 509.51  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462591981  49 MCFLGfaifAMIILLPFRLKLnewGTIIFSCFVCIGQVVFALGGIFNAFWLMEFGRFVFGIGGESLAVAQNTYAVSWFKG 128
Cdd:cd17340    50 LCFFG----GFLIDRVFGIRL---GTIIFSLLVLIGQLIFALGALTNLFWLMLVGRFIFGIGGESLAVAQNTYAVSWFKG 122

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462591981 129 KELNLVFGLQLSMARIGSTVNMNLMGWLYSKIEALlgSAGHTTLGITLMIGGVTCILSLICALALAYLDQRAERILHKEQ 208
Cdd:cd17340   123 KELNLVFGLQLSFARIGSTVNFNVMPPIYKRISDF--YSGYKSLGVALWIGAITCLFSLICAIILGLLDKRAERILKKES 200

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462591981 209 GKTGEVIKLTDVKDFSLPLWLIFIICVCYYVAVFPFIGLGKVFFTEKFGFSSQAASAINSVVYVISAPMSPVFGLLVDKT 288
Cdd:cd17340   201 NKTGEVIKLSDVKDFPLSFWLICIICVFYYVAVFPFIGLGTVFFEEKYGFSPSEAAAVNSIVYIISAAASPVFGFLVDKV 280

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462591981 289 GKNIIWVLCAVAATLVSHMMLAFTMWNPWIAMCLLGLSYSLLACALWPMVAFVVPEHQLGTAYGFMQSIQNLGLAIISII 368
Cdd:cd17340   281 GRNILWVLIALVITLLGHLLLAFTFVNPLIAMVIMGIGYSMLACALWPMVPLVVPEHQLGTAYGFMQSIQNLGLAVFPII 360

                         330       340
                  ....*....|....*....|
gi 2462591981 369 AGMILDSRGYLFLEVFFIAC 388
Cdd:cd17340   361 AGSILDKKGYLLLEVFFIAC 380
 
Name Accession Description Interval E-value
MFS_MFSD1 cd17340
Major facilitator superfamily domain-containing protein 1; Human major facilitator superfamily ...
 49-388 0e+00

Major facilitator superfamily domain-containing protein 1; Human major facilitator superfamily domain-containing protein 1 (MFSD1) is also called smooth muscle cell-associated protein 4 (SMAP-4). The function of MFSD1 is still unknown. Its expression is affected by altered nutrient intake. During starvation, expression of MFSD1 is downregulated in anterior brain sections in mice while it is upregulated in the brainstem. In mice raised on high-fat diet, MFSD1 is specifically downregulated in brainstem and hypothalamus. MFSD1 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340898 [Multi-domain]  Cd Length: 394  Bit Score: 509.51  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462591981  49 MCFLGfaifAMIILLPFRLKLnewGTIIFSCFVCIGQVVFALGGIFNAFWLMEFGRFVFGIGGESLAVAQNTYAVSWFKG 128
Cdd:cd17340    50 LCFFG----GFLIDRVFGIRL---GTIIFSLLVLIGQLIFALGALTNLFWLMLVGRFIFGIGGESLAVAQNTYAVSWFKG 122

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462591981 129 KELNLVFGLQLSMARIGSTVNMNLMGWLYSKIEALlgSAGHTTLGITLMIGGVTCILSLICALALAYLDQRAERILHKEQ 208
Cdd:cd17340   123 KELNLVFGLQLSFARIGSTVNFNVMPPIYKRISDF--YSGYKSLGVALWIGAITCLFSLICAIILGLLDKRAERILKKES 200

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462591981 209 GKTGEVIKLTDVKDFSLPLWLIFIICVCYYVAVFPFIGLGKVFFTEKFGFSSQAASAINSVVYVISAPMSPVFGLLVDKT 288
Cdd:cd17340   201 NKTGEVIKLSDVKDFPLSFWLICIICVFYYVAVFPFIGLGTVFFEEKYGFSPSEAAAVNSIVYIISAAASPVFGFLVDKV 280

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462591981 289 GKNIIWVLCAVAATLVSHMMLAFTMWNPWIAMCLLGLSYSLLACALWPMVAFVVPEHQLGTAYGFMQSIQNLGLAIISII 368
Cdd:cd17340   281 GRNILWVLIALVITLLGHLLLAFTFVNPLIAMVIMGIGYSMLACALWPMVPLVVPEHQLGTAYGFMQSIQNLGLAVFPII 360

                         330       340
                  ....*....|....*....|
gi 2462591981 369 AGMILDSRGYLFLEVFFIAC 388
Cdd:cd17340   361 AGSILDKKGYLLLEVFFIAC 380
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
83-388 5.82e-23

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 99.57  E-value: 5.82e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462591981  83 IGQVVFALGGIFNAF----WLMEFGRFVFGIG-GESLAVAQnTYAVSWFKGKELNLVFGLQLSMARIGSTVNMNLMGWLY 157
Cdd:COG2223    75 IGLLLLGIGLLLLALavsyWLLLLLGLLLGIGgGGSFAVGI-ALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLI 153

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462591981 158 skieallgsaghTTLGITLMIGGVTCILSLICALALAYLDQRAERILHKEQGKTGEVIKLTDVKDFslplWLIFIICVCY 237
Cdd:COG2223   154 ------------AAFGWRNAFLILGILLLVVAVLAWLFLRDPPAGAAAAAKASLRDQLEALRDPRF----WLLSLLYFGT 217

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462591981 238 YVAVFPFIGLGKVFFTEKFGFSSQAASAINSVVYVISAPMSPVFGLLVDKTGKNIIWVLCAVAATLVShMMLAFTMWNPW 317
Cdd:COG2223   218 FGSFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGL-LLLALALGSLW 296

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2462591981 318 ---IAMCLLGLSYSLLACALWPMVAFVVPEHQLGTAYGFMQSIQNLGLAIISIIAGMILDSRG-----YLFLEVFFIAC 388
Cdd:COG2223   297 lflVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGsytaaFLVFAVLALVA 375
MFS_1 pfam07690
Major Facilitator Superfamily;
80-364 5.10e-16

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 78.61  E-value: 5.10e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462591981  80 FVCIGQVVFALGGIF----NAFWLMEFGRFVFGIGGESLAVAQNTYAVSWFKGKELNLVFGLQLSMARIGSTVNMNLMGW 155
Cdd:pfam07690  64 VLLIGLLLFALGLLLllfaSSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGL 143

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462591981 156 LYSKIEallgsaghttlgiTLMIGGVTCILSLICALALAYLDQRAERILHKEQGKTGEVIKLTdVKDFSLPLWLIFIICV 235
Cdd:pfam07690 144 LASLFG-------------WRAAFLILAILSLLAAVLLLLPRPPPESKRPKPAEEARLSLIVA-WKALLRDPVLWLLLAL 209

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462591981 236 CYYVAVFPFIGLGKVFFTEKFGFSSQAASAINSVVYVISAPMSPVFGLLVDKTGKNIIWVLCAVAATLVS----HMMLAF 311
Cdd:pfam07690 210 LLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAAlgllLLSLTL 289

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2462591981 312 TMWNPWIAMCLLGLSYSLLACALWPMVAFVVPEHQLGTAYGFMQSIQNLGLAI 364
Cdd:pfam07690 290 SSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGAL 342
2A0114 TIGR00893
D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, ...
 104-377 7.37e-09

D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273326 [Multi-domain]  Cd Length: 399  Bit Score: 57.35  E-value: 7.37e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462591981 104 RFVFGIGGESLAVAQNTYAVSWFKGKELNLVFGLQLSMARIGSTVNMNLMGWLYSkieallgsagHTTLGITLMIGGVTC 183
Cdd:TIGR00893  89 RVLLGAAEAPFFPGIILIVASWFPASERATAVSIFNSAQGLGGIIGGPLVGWILI----------HFSWQWAFIIEGVLG 158

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462591981 184 ILSLICALAL--------AYLDQRAERILHK-----EQGKTGEVIKLTDVKD--FSLPLWLIFIICVCYYVAVFPFIGLG 248
Cdd:TIGR00893 159 IIWGVLWLKFipdppqkaKWLTEEEKYIVVGgllaeQQGKGPSTPKKYQIKEllKDRRVWGLALGQFLVNIGLGFFLTWF 238

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462591981 249 KVFFTEKFGFSSQAASAINSVVYVISAPMSPVFGLLVD---KTGKNIIWVLCAVAATLVSHMMLAF---TMWNPWIAMCL 322
Cdd:TIGR00893 239 PTYLVQERGLSILEAGFMASLPGIVGFIGMILGGRLSDlllRRGKSLVFARKTAIIAGLVLSLLMFatnYVNIPYAALAL 318

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2462591981 323 LGLSY--SLLACALWPMVAFVVPEHQLGTAYGFMQSIQNLGLAIISIIAGMILDSRG 377
Cdd:TIGR00893 319 VALGFfgLGAGAIGWALISDNAPGNIAGLTGGLINSLGNLGGIVGPIVIGAIAATTG 375
PRK08633 PRK08633
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated
 282-385 9.43e-04

2-acyl-glycerophospho-ethanolamine acyltransferase; Validated


Pssm-ID: 236315 [Multi-domain]  Cd Length: 1146  Bit Score: 41.83  E-value: 9.43e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462591981  282 GLLVDKTGKNIIWVLCAVAATLVSHMM-LAFTMWNPWIAMC---LLGLSYSLLACALWPMVAFVVPEHQLGTAYGFMQSI 357
Cdd:PRK08633    68 GFLADKFSKNRVIRIVKLFEVGLTLLIvLAYYLGWFWLAFAvtfLLGAQSAIYSPAKYGIIPELVGKENLSRANGLLEAF 147

                           90       100
                   ....*....|....*....|....*...
gi 2462591981  358 qnlglAIISIIAGMILDSrgyLFLEVFF 385
Cdd:PRK08633   148 -----TIVAILAGTALFS---FLFESVN 167
 
Name Accession Description Interval E-value
MFS_MFSD1 cd17340
Major facilitator superfamily domain-containing protein 1; Human major facilitator superfamily ...
 49-388 0e+00

Major facilitator superfamily domain-containing protein 1; Human major facilitator superfamily domain-containing protein 1 (MFSD1) is also called smooth muscle cell-associated protein 4 (SMAP-4). The function of MFSD1 is still unknown. Its expression is affected by altered nutrient intake. During starvation, expression of MFSD1 is downregulated in anterior brain sections in mice while it is upregulated in the brainstem. In mice raised on high-fat diet, MFSD1 is specifically downregulated in brainstem and hypothalamus. MFSD1 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340898 [Multi-domain]  Cd Length: 394  Bit Score: 509.51  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462591981  49 MCFLGfaifAMIILLPFRLKLnewGTIIFSCFVCIGQVVFALGGIFNAFWLMEFGRFVFGIGGESLAVAQNTYAVSWFKG 128
Cdd:cd17340    50 LCFFG----GFLIDRVFGIRL---GTIIFSLLVLIGQLIFALGALTNLFWLMLVGRFIFGIGGESLAVAQNTYAVSWFKG 122

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462591981 129 KELNLVFGLQLSMARIGSTVNMNLMGWLYSKIEALlgSAGHTTLGITLMIGGVTCILSLICALALAYLDQRAERILHKEQ 208
Cdd:cd17340   123 KELNLVFGLQLSFARIGSTVNFNVMPPIYKRISDF--YSGYKSLGVALWIGAITCLFSLICAIILGLLDKRAERILKKES 200

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462591981 209 GKTGEVIKLTDVKDFSLPLWLIFIICVCYYVAVFPFIGLGKVFFTEKFGFSSQAASAINSVVYVISAPMSPVFGLLVDKT 288
Cdd:cd17340   201 NKTGEVIKLSDVKDFPLSFWLICIICVFYYVAVFPFIGLGTVFFEEKYGFSPSEAAAVNSIVYIISAAASPVFGFLVDKV 280

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462591981 289 GKNIIWVLCAVAATLVSHMMLAFTMWNPWIAMCLLGLSYSLLACALWPMVAFVVPEHQLGTAYGFMQSIQNLGLAIISII 368
Cdd:cd17340   281 GRNILWVLIALVITLLGHLLLAFTFVNPLIAMVIMGIGYSMLACALWPMVPLVVPEHQLGTAYGFMQSIQNLGLAVFPII 360

                         330       340
                  ....*....|....*....|
gi 2462591981 369 AGMILDSRGYLFLEVFFIAC 388
Cdd:cd17340   361 AGSILDKKGYLLLEVFFIAC 380
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 49-374 1.82e-26

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 109.44  E-value: 1.82e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462591981  49 MCFLGFAIFAMIILLPFRLKLNEWGT-IIFSCFVCIGQVVFALGGIFNAFWLMEFGRFVFGIGGESLAVAQNTYAVSWFK 127
Cdd:cd06174    35 LLFALFSLGYALLQPLAGLLADRFGRrPVLLLGLLLFALGALLFAFAPSFWLLLLGRFLLGLGSGLIDPAVLALIADLFP 114

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462591981 128 GKELNLVFGLQLSMARIGSTVNMNLMGWLYSKIEALLGSAghttlgitLMIGGVTCILSLIcALALAYLDQRAERILHKE 207
Cdd:cd06174   115 ERERGRALGLLQAFGSVGGILGPLLGGILASSLGFGWRAV--------FLIAAALALLAAI-LLLLVVPDPPESARAKNE 185

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462591981 208 QGKTGEVIKLTDVKDFSLPLWLIFIICVCYYVAVFPFIGLGKVFFTEKFGFSSQAASAINSVVYVISAPMSPVFGLLVDK 287
Cdd:cd06174   186 EASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDR 265

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462591981 288 TG--KNIIWVLCAVAATLVSHMMLAFTMWNPWIAMCLLGLSYSLLACALWPMVAFVVPEHQLGTAYGFMQSIQNLGLAII 365
Cdd:cd06174   266 LIgrKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIG 345


                  ....*....
gi 2462591981 366 SIIAGMILD 374
Cdd:cd06174   346 PLLAGFLLA 354
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
83-388 5.82e-23

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 99.57  E-value: 5.82e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462591981  83 IGQVVFALGGIFNAF----WLMEFGRFVFGIG-GESLAVAQnTYAVSWFKGKELNLVFGLQLSMARIGSTVNMNLMGWLY 157
Cdd:COG2223    75 IGLLLLGIGLLLLALavsyWLLLLLGLLLGIGgGGSFAVGI-ALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLI 153

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462591981 158 skieallgsaghTTLGITLMIGGVTCILSLICALALAYLDQRAERILHKEQGKTGEVIKLTDVKDFslplWLIFIICVCY 237
Cdd:COG2223   154 ------------AAFGWRNAFLILGILLLVVAVLAWLFLRDPPAGAAAAAKASLRDQLEALRDPRF----WLLSLLYFGT 217

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462591981 238 YVAVFPFIGLGKVFFTEKFGFSSQAASAINSVVYVISAPMSPVFGLLVDKTGKNIIWVLCAVAATLVShMMLAFTMWNPW 317
Cdd:COG2223   218 FGSFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGL-LLLALALGSLW 296

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2462591981 318 ---IAMCLLGLSYSLLACALWPMVAFVVPEHQLGTAYGFMQSIQNLGLAIISIIAGMILDSRG-----YLFLEVFFIAC 388
Cdd:COG2223   297 lflVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGsytaaFLVFAVLALVA 375
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
83-361 1.04e-17

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 83.87  E-value: 1.04e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462591981  83 IGQVVFALGGIFNAF----WLMEFGRFVFGIGGESLAVAQNTYAVSWFKGKELNLVFGLQLSMARIGSTVNMNLMGWLys 158
Cdd:COG2814    80 LGLLLFALGSLLCALapslWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLL-- 157

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462591981 159 kieallgsAGHTTLGITLMIGGVTCILSLIcaLALAYLDQRAERILHKEQGKTGEVIKLTdvkdfslPLWLIFIICVCYY 238
Cdd:COG2814   158 --------ADLFGWRWVFLVNAVLALLALL--LLLRLLPESRPAARARLRGSLRELLRRP-------RLLLLLLLAFLLG 220

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462591981 239 VAVFPFIGLGKVFFTEKFGFSSQAASAINSVVYVISAPMSPVFGLLVDKTG-KNIIWVLCAVAATLVSHMMLAFTMWNPW 317
Cdd:COG2814   221 FGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGrRRLLLIGLLLLALGLLLLALAGSLWLLL 300

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 2462591981 318 IAMCLLGLSYSLLACALWPMVAFVVPEHQLGTAYGFMQSIQNLG 361
Cdd:COG2814   301 LALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLG 344
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
86-388 1.21e-17

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 83.77  E-value: 1.21e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462591981  86 VVFALGGIFNAFWLMEFGRFVFGIGGESLAVAQNTYAVSWFKGKELNLVFGLQLSMARIGSTVNMNLMGWLyskieallg 165
Cdd:COG2271    87 LATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWL--------- 157

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462591981 166 sAGHTTLGITLMIGGVTCILSLIcalalayldqraerilhkeqgktgevikltdvkdfsLPLWLIFIICVCYYVAVFPFI 245
Cdd:COG2271   158 -LAAFGWRAAFLILGLPGLLLAL------------------------------------LRFWLLALAYFLVYFALYGFL 200

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462591981 246 GLGKVFFTEKFGFSSQAASAINSVVYVISAPMSPVFGLLVDKTGKNIIWVLCAVAATLVSHMMLAFTMWNPW---IAMCL 322
Cdd:COG2271   201 TWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAIGLLLAALALLLLALLPSPAlaiALLFL 280

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462591981 323 LGLSYSLLACALWPMVAFVVPEHQLGTAYGFMQSIQNLGLAIISIIAGMILDSRGYLFLEVFFIAC 388
Cdd:COG2271   281 AGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAAL 346
MFS_1 pfam07690
Major Facilitator Superfamily;
80-364 5.10e-16

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 78.61  E-value: 5.10e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462591981  80 FVCIGQVVFALGGIF----NAFWLMEFGRFVFGIGGESLAVAQNTYAVSWFKGKELNLVFGLQLSMARIGSTVNMNLMGW 155
Cdd:pfam07690  64 VLLIGLLLFALGLLLllfaSSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGL 143

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462591981 156 LYSKIEallgsaghttlgiTLMIGGVTCILSLICALALAYLDQRAERILHKEQGKTGEVIKLTdVKDFSLPLWLIFIICV 235
Cdd:pfam07690 144 LASLFG-------------WRAAFLILAILSLLAAVLLLLPRPPPESKRPKPAEEARLSLIVA-WKALLRDPVLWLLLAL 209

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462591981 236 CYYVAVFPFIGLGKVFFTEKFGFSSQAASAINSVVYVISAPMSPVFGLLVDKTGKNIIWVLCAVAATLVS----HMMLAF 311
Cdd:pfam07690 210 LLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAAlgllLLSLTL 289

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2462591981 312 TMWNPWIAMCLLGLSYSLLACALWPMVAFVVPEHQLGTAYGFMQSIQNLGLAI 364
Cdd:pfam07690 290 SSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGAL 342
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
140-378 1.09e-15

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 78.41  E-value: 1.09e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462591981 140 SMARIGSTVNMNLMGWLYSKIEALLGSAGHTTLGITLMIGGVTCILS-LICALALAyldqraERILHKEQGKTGevikLT 218
Cdd:COG2211   150 SWRFAFAGLGGLLASVLPPPLVAAFGGDAALGYRLTALIFAVLGLLAfLLTFFGTK------ERPVPEEEKVSL----KE 219

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462591981 219 DVKDF--SLPLWLIFIICVCYYVAVFPFIGLGKVFFTEKFGFSSQAASAINSVVYVISAPMSPVFGLLVDKTGKNIIWVL 296
Cdd:COG2211   220 SLKALlkNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFII 299

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462591981 297 CAVAATLVSHMMLAFTMWNPW---IAMCLLGLSYSLLACALWPMVAFVVPEHQL-------GTAYGFMQSIQNLGLAIIS 366
Cdd:COG2211   300 GLLLAALGLLLLFFLGPGNLWlllVLAALAGIGLGAILVLPWAMLADVVDYDEWktgrrreGLYFGIFTFAIKLGQALAG 379

                         250
                  ....*....|..
gi 2462591981 367 IIAGMILDSRGY 378
Cdd:COG2211   380 ALAGLLLALFGY 391
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 86-388 1.44e-14

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 74.53  E-value: 1.44e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462591981  86 VVFALGGIFNAFWLMEFGRFVFGIGGESLAVAQNTYAVSWFKGKELNLVFGLQLSMARIGSTVNMNLMGWLYSKIeallg 165
Cdd:cd17325    73 VSTLLFAFATSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADAL----- 147

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462591981 166 saGHTTLGItlmiggVTCILSLICALALAYLDQRAERILHKEQGKTGEVIKLTDVKDFSLPLWLIFIICVCYYVAVFPFI 245
Cdd:cd17325   148 --GYRAPFL------VCAALALLALVLALLLLPEPRPPPNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALE 219

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462591981 246 GLGKVFFTEKFGFSSQAASAINSVVYVISAPMSPVFGLLVDKTGKNII----WVLCAVAATLVShmmLAFTMWNPWIAMC 321
Cdd:cd17325   220 PFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLiligLLLSAVALLLLP---LATSFWLLLLLLA 296

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462591981 322 LLGLSYSLLACALWPMVAFVVPEHQLGTAYGFMQSIQNLGLAIISIIAGMILDSRGY----LFLEVFFIAC 388
Cdd:cd17325   297 LLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFatpfLAAAALLLLA 367
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
 51-388 1.95e-11

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 64.90  E-value: 1.95e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462591981  51 FLGFAIFAmiilLPFRLKLNEWGT-IIFSCFVCIGQVVFALGGIFNAFWLMEFGRFVFGIGGESLAVAQNTYAVSWFKGK 129
Cdd:cd17319    48 FLGYALFQ----VPGGWLLDRFGArKVLAVSMLLWSLFTALTGFATSLTSLYVLRFLLGVAEAGFFPGAIKALAEWFPAR 123

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462591981 130 ELNLVFGLQLSMARIGSTVNMNLMGWLyskiealLGSAGHTTLGITlmIGGVTCILSLICalaLAYLDQraerilhkeqg 209
Cdd:cd17319   124 ERGRATGLFNSGAPLGAAIGPPLSGWL-------LLLFGWRWAFII--EGLLGLLLAVLW---WFYLRQ----------- 180

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462591981 210 ktgevikltdvkdfslpLWLIFIICVCYYVAVFPFIGLGKVFFTEKFGFSSQAASAINSVVYVISAPMSPVFGLLVDKTG 289
Cdd:cd17319   181 -----------------VWGLALGYFGINYALYGLLTWLPTYLKQARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRLL 243

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462591981 290 ----KNIIWVLCAVAATLvshMMLAFTMWNPWIAMCLLGLSYSLLACA---LWPMVAFVVPEHQLGTAYGFMQSIQNLGL 362
Cdd:cd17319   244 rgarRLVIIIGLLLAAVG---LLLAYLTTSPVVAVILLSLAGFGIGAAspvFWSLPADLLPGEAAATAGGLINSGGNLGG 320

                         330       340
                  ....*....|....*....|....*.
gi 2462591981 363 AIISIIAGMILDSRGYLFLEVFFIAC 388
Cdd:cd17319   321 FVAPLLIGYLVDATGSYTAAFLFLAA 346
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 227-388 3.47e-10

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 61.08  E-value: 3.47e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462591981 227 LWLIFIICVCYYVAVFPFIGLGKVFFTEKFGFSSQAASAINSVVYVISAPMSPVFGLLVDKTGKNIIWVLCAVAATLVSH 306
Cdd:cd17316   179 TLLLILLWFFISFGYYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILAL 258

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462591981 307 MMLAFTMWNPW---IAMCLLGLSYSLLACALWPMVAFVVPEHQLGTAYGFMQSIQNLGLAIISIIAGMILDSRGYLFLEV 383
Cdd:cd17316   259 PLFYLLSGSPTlllLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLASTGGTGVPA 338


                  ....*
gi 2462591981 384 FFIAC 388
Cdd:cd17316   339 LILAL 343
MFS_MJ1317_like cd17370
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ...
 202-384 2.00e-09

MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340928 [Multi-domain]  Cd Length: 371  Bit Score: 58.71  E-value: 2.00e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462591981 202 RILHKEQGKTGEVIKLTDVKDFSLPLWLIFIICVCYYVAVFPFIGLgkVFFTEKFGFSSQAASAINSVVYVISAPMSPVF 281
Cdd:cd17370   177 VKEYPRPPKLRKKSKKTSLKKLPKAFWLYLLAVALFALGNFSFAFL--ILRAQELGLSAALIPLLYALFNLVYALAAYPA 254

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462591981 282 GLLVDKTG-KNIIWV--LCAVAATLVshMMLAFTMWNPWIAMCLLGLSYSLLACALWPMVAFVVPEHQLGTAYGFMQSIQ 358
Cdd:cd17370   255 GRLSDRIGrKKLLILgyLSLALAYLG--FALGSSLWLLLLGFILWGLYMGAQESIERAAVADLVPAELRGTAYGLFNTVV 332

                         170       180
                  ....*....|....*....|....*.
gi 2462591981 359 NLGLAIISIIAGMILDSRGYLFLEVF 384
Cdd:cd17370   333 GIGWLLASLIAGYLWDLISPSAAFLF 358
2A0114 TIGR00893
D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, ...
 104-377 7.37e-09

D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273326 [Multi-domain]  Cd Length: 399  Bit Score: 57.35  E-value: 7.37e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462591981 104 RFVFGIGGESLAVAQNTYAVSWFKGKELNLVFGLQLSMARIGSTVNMNLMGWLYSkieallgsagHTTLGITLMIGGVTC 183
Cdd:TIGR00893  89 RVLLGAAEAPFFPGIILIVASWFPASERATAVSIFNSAQGLGGIIGGPLVGWILI----------HFSWQWAFIIEGVLG 158

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462591981 184 ILSLICALAL--------AYLDQRAERILHK-----EQGKTGEVIKLTDVKD--FSLPLWLIFIICVCYYVAVFPFIGLG 248
Cdd:TIGR00893 159 IIWGVLWLKFipdppqkaKWLTEEEKYIVVGgllaeQQGKGPSTPKKYQIKEllKDRRVWGLALGQFLVNIGLGFFLTWF 238

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462591981 249 KVFFTEKFGFSSQAASAINSVVYVISAPMSPVFGLLVD---KTGKNIIWVLCAVAATLVSHMMLAF---TMWNPWIAMCL 322
Cdd:TIGR00893 239 PTYLVQERGLSILEAGFMASLPGIVGFIGMILGGRLSDlllRRGKSLVFARKTAIIAGLVLSLLMFatnYVNIPYAALAL 318

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2462591981 323 LGLSY--SLLACALWPMVAFVVPEHQLGTAYGFMQSIQNLGLAIISIIAGMILDSRG 377
Cdd:TIGR00893 319 VALGFfgLGAGAIGWALISDNAPGNIAGLTGGLINSLGNLGGIVGPIVIGAIAATTG 375
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 184-387 4.47e-08

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 54.86  E-value: 4.47e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462591981 184 ILSLICALALAYLdqrAERILHKEQGKTGEVIKLTDVKdFSLPLWLIFIICVCYY---VAVFPFIGLgkvFFTEKFGFSS 260
Cdd:cd17324   161 VLALLAALLLWRL---LPSLPPKKPGSLGLLSSLLLLL-RNPRLRLAYLITFLLFggfFALYTYLAP---FLTDVPGFSS 233

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462591981 261 QAASAINSVVYVISAPMSPVFGLLVDKTG-KNIIWVLCAVAATLVSHMMLAFTMWNPWIAMCLLGLSYSLLACALWPMVA 339
Cdd:cd17324   234 SAIIGLLLLFGVAGVVGSPLAGRLADRGGrRALLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVL 313

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 2462591981 340 FVVPEHQlGTAYGFMQSIQNLGLAIISIIAGMILDSRGYLFLEVFFIA 387
Cdd:cd17324   314 RLAPEAR-GLASSLYLAAYNLGGALGAALGGLVLDHGGWAGVGWVGAA 360
MFS_1 pfam07690
Major Facilitator Superfamily;
230-378 1.72e-07

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 52.81  E-value: 1.72e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462591981 230 IFIICVCYYVAVFPFIGLGKVFFTEKFGFSSQAASAINSVVYVISAPMSPVFGLLVDKTGKNIIWVLCAVAATLVSHMML 309
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462591981 310 AFTMWNPWIAM-CLLGLSYSLLACALWPMVAFVVPEHQLGTAYGFMQSIQNLGLAIISIIAGMILDSRGY 378
Cdd:pfam07690  81 FASSLWLLLVLrVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGW 150
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
228-378 2.17e-07

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 52.56  E-value: 2.17e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462591981 228 WLIFIICVCYYVAVFPF---IGLGKVFFTEKFGFSSQAASAINSVVYVISAPMSPVFGLLVDKTGKNIIWVLCAVAATLV 304
Cdd:COG2271     9 WRILALLFLAYFLNYLDrsnLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLA 88

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2462591981 305 ShmMLAFTMWNPW---IAMCLLGLSYSLLACALWPMVAFVVPEHQLGTAYGFMQSIQNLGLAIISIIAGMILDSRGY 378
Cdd:COG2271    89 T--LLFGFATSFWqllLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGW 163
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 256-388 2.47e-07

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 52.43  E-value: 2.47e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462591981 256 FGFSSQAASAINSVVYVISAPMSPVFGLLVDKTGKNIIWVLCAVAATLVSH-MMLAFTMWNPWIAMCLLGLSYSLLACAL 334
Cdd:cd06174    26 FGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALlFAFAPSFWLLLLGRFLLGLGSGLIDPAV 105

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2462591981 335 WPMVAFVVPEHQLGTAYGFMQSIQNLGLAIISIIAGMILDSRGYLFLEVFFIAC 388
Cdd:cd06174   106 LALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGFGWRAVFLIAA 159
MFS_MelB_like cd17332
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ...
 143-378 3.55e-07

Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340890 [Multi-domain]  Cd Length: 424  Bit Score: 52.22  E-value: 3.55e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462591981 143 RIGSTVNMNLMGWLYSKIEALLGSaGHTTLGITLMiGGVTCILSLICALALAYldQRAERILHKEQGKTGEVIKLTDVKD 222
Cdd:cd17332   142 MFFATIGGLLVTVLPPPLVAYFGG-GNASRGYFLT-ALIIGIIGIILLLICFF--GTRERVVPPEEEKSKLPLLKSLKAL 217

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462591981 223 FSLPLWLIFIIC-VCYYVAVFPFIGLGKVFFTEKFGFSSQAASAINSVVyVISAPMSPVFGLLVDKTGKNIIWVLCAVAA 301
Cdd:cd17332   218 LKNRPFLILLLAyLLYFLAFNIVNTVLVYYFKYVLGGRAELVLLLLLIL-SGALLALLPWPPLKKRFGKKKAFFIGLLLA 296

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462591981 302 TLVSHMMLAFTMWNPW---IAMCLLGLSYSLLACALWPMVAFVVPEHQL-------GTAYGFMQSIQNLGLAIISIIAGM 371
Cdd:cd17332   297 ILGLLLLFFLPPGNLVlilVLAVLAGIGYGGANLLPWAMLADVIDYGELktgkrreGIFYSVMTFFRKLGLALAGALVGL 376


                  ....*..
gi 2462591981 372 ILDSRGY 378
Cdd:cd17332   377 ILSLAGY 383
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
72-388 6.34e-07

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 51.01  E-value: 6.34e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462591981  72 WGTIIFSCFVCIGQVVFALGGifnAFWLMEFGRFVFGIGGESLAVAQNTYAVSWFKGKELNLVFGLQLSMArIGSTVNMN 151
Cdd:COG0738    74 RGLLLGLLLMALGLLLFALAP---SYPLLLLALFLLGLGLGLLDVAANPYVAALGPETAASRLNLLHAFFS-LGALLGPL 149

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462591981 152 LMGWLyskieaLLGSAGHTTLGITLMIGGVTCILSLICALALAYLDQRAERILHKEQGKTGEVIKLTdvkdfslPLWLIF 231
Cdd:COG0738   150 LGGLL------ILLGLSLSWHLPYLILAVLLLLLALLFLRSKLPEIEEEEEEAAGSAASLKSLLKNP-------RLLLGG 216

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462591981 232 IICVCYYVAVFPFIGLGKVFFTEKFGFSSQAASAINSVVYVISAPMSPVFGLLVDKTG-KNIIWVLCAVAATLVSHMMLA 310
Cdd:COG0738   217 LAIFLYVGAEGAIGDWLPLYLKDVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGpVRLLRLSALLAAVGLLLALLA 296

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2462591981 311 FTMWNPWIAMCLLGLSYSLLACALWPMVAFVVPEHQlGTAYGFMQSIQNLGLAIISIIAGMILDSRGYLFLEVFFIAC 388
Cdd:COG0738   297 PGPWLALIGLALVGLGLSLMFPTIFSLALDGLGKRT-AAAVSAVLIMGIVGGAIGPPLIGFLADAFGLRAAFLVPLVC 373
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 83-376 7.51e-07

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 51.02  E-value: 7.51e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462591981  83 IGQVVFALG----GIFNAFWLMEFGRFVFGIGGESLAVAQNTYAVSWFKGKELNLVFGLQLSMARIGSTVNMNLMGWLys 158
Cdd:cd17321    66 IGLALFGLAsllcALAPSLAFLIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLL-- 143

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462591981 159 kieallgsAGHTTLGITLMIGGVTCILSLICAlalayldqraerilhkeqgktgevikltdvKDFSLPLWLIFIICVCYY 238
Cdd:cd17321   144 --------LELFGWRWIFLINVPIGLVALLLA------------------------------RTFSGAVLAAFLLGAALG 185

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462591981 239 VAVFPFIglgkVFFTEKFGFSSQAASAINSVVYVISAPMSPVFGLLVDKTGKNII----WVLCAVAATLVSHMMLAFTMW 314
Cdd:cd17321   186 GLLFLLP----LYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVlvagLLLTAVGLLLLALLGADSSVW 261

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462591981 315 NPWIAMCLLGLSYSLLACALWPMVAFVVPEHQLGTAYGFMQSIQNLGLAIISIIAGMILDSR 376
Cdd:cd17321   262 LLLPGLVLLGLGLGLFATPLTNAALSSVPKEKAGAASGILNTARQLGGALGVALLGALLTAG 323
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
81-377 1.45e-06

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 50.26  E-value: 1.45e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462591981  81 VCIGQVVFALG----GIFNAFWLMEFGRFVFGIGGESLAVAQNTYAVSWFkGKELNLVFGLQLSMARIGSTVNMNLMGWL 156
Cdd:COG2807    86 LLLALLLLAAGlllrSLAPSVALLLAGTALIGAGIAVGNVLLPGLIKRWF-PDRVGLMTGLYTAAMGLGAALAAGLTVPL 164

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462591981 157 yskieallgsAGHTTLGITLMIGGVTCILSLICALALAyLDQRAERILHKEQGKTGEVIKltdvkdfSLPLWLI----FI 232
Cdd:COG2807   165 ----------AAALGWRGALAVWALLALLALLLWLPLL-RRRPAAAAAAPAAASLRSLWR-------SPLAWLLtlffGL 226

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462591981 233 ICVCYYVavfpFIGLGKVFFTEKfGFSSQAASAINSVVYVISAPMSPVFGLLVDKTGKNIIWVLCAVAATLVSHMMLAFT 312
Cdd:COG2807   227 QSLLYYA----VVAWLPPILRDA-GLSAATAGLLLSLFQLAGIPGSLLVPLLADRLGDRRPLLLLLGLLGLAGLLGLLLA 301

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462591981 313 -MWNPWIAMCLLGLSYSllacALWPMVAFVVPEH-----QLGTAYGFMQSIQNLGLAIISIIAGMILDSRG 377
Cdd:COG2807   302 pGSLPWLWAVLLGLGQG----GLFPLALTLIGLRartpaEAAALSGMAQSVGYLLAALGPLLVGALHDATG 368
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 83-378 1.53e-06

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 49.90  E-value: 1.53e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462591981  83 IGQVVFALGGIF----NAFWLMEFGRFVFGIGGESLAVAQNTYAVSwfkgkelnlvfglQLSMARIGSTVNMNLMG-WLY 157
Cdd:cd17489    66 IGLLIFALATLLyllaTSVALLLVLRLIHGIGWGAFTTAAATLVAD-------------IIPPSRRGEGIGYYGLAtTLA 132

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462591981 158 SKIEALLGSAGHTTLGITlMIGGVTCILSLICALALAYLDQRaerilHKEQGKTGEVIKLTDVKDFSLPLWLIFIICVCY 237
Cdd:cd17489   133 MALGPALGLFLYQHLGFA-VLFIVAAVLALLALLLVFLVKDP-----PPVAAEEAEAGTRAFRRLVEKKVLPPALILFLA 206

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462591981 238 YVAVFPFIGLGKVFFTEKFGFSSQAASAINSVVYVIsapMSPVFGLLVDKTGKNIIWVLCAVAATLVshMMLAFTMWNPW 317
Cdd:cd17489   207 SIAYGAISTFLPLYAAERGISNAGLFFTVYAIALLL---SRPFSGKLSDRKGPKTVIIPGLLLLALG--LLLLSFAGSPW 281

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2462591981 318 ---IAMCLLGLSYSLLACALWPMVAFVVPEHQLGTAYGFMQSIQNLGLAIISIIAGMILDSRGY 378
Cdd:cd17489   282 mllLAAVLYGLGFGLLFPALQALAVDLVPPHRRGAANGTFFIFFDLGIGLGGLLLGLVAELFGY 345
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
250-377 1.65e-06

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 49.90  E-value: 1.65e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462591981 250 VFFTEKFGFSSQAASAINSVVYVISAPMSPVFGLLVDKT----GKNIIWVL-CAVAATLVSHMMLAFTMWNPW------- 317
Cdd:COG2211    35 YFYTDVLGLSAALVGLILLVARLWDAITDPLIGALSDRTrtrwGRRRPWILiGAIPLALSFVLLFTAPDLSPTgkliyal 114

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462591981 318 IAMCLLGLSYSLLACALWPMVAFVVPE-HQLGTAYGFMQSIQNLGLAIISIIAGMILDSRG 377
Cdd:COG2211   115 VTYLLLGLAYTLVNIPYSALGAELTPDyEERTRLSSWRFAFAGLGGLLASVLPPPLVAAFG 175
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
225-378 3.18e-06

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 48.82  E-value: 3.18e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462591981 225 LPLWLIFIICVCYYVAVFpFIGLGKVFFTEKFGFSSQAASAINSVVYVISAPMSPVFGLLVDKTGKNIIWVLCAVAATLV 304
Cdd:COG2814    10 LALLALALGAFLSGLGIG-IVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALG 88

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2462591981 305 ShmMLAFTMWNPW---IAMCLLGLSYSLLACALWPMVAFVVPEHQLGTAYGFMQSIQNLGLAIISIIAGMILDSRGY 378
Cdd:COG2814    89 S--LLCALAPSLWlllAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGW 163
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
 81-388 5.37e-06

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 48.34  E-value: 5.37e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462591981  81 VCIGQVVFALGGI----FNAFWLMEFGRFVFGIGGESLAVAQNTYAVSWFKGKELNLVFGLQLSMARIGSTVNMNLMGWL 156
Cdd:cd17473    68 LIAGLLLYGIGGVaglfLDSLYALLASRALLGIGVAGIMTLATALIGDYFEGEERAKMLGLQSAAMSLGGVVFLLLGGAL 147

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462591981 157 yskieALLGSagHTTLGITLmiggvtciLSLICALALAYLDQRAERILHKEQGKTGEVIKLTDVKDFSLPLWLIFIICVC 236
Cdd:cd17473   148 -----AEIGW--RAPFLVYL--------LALPVLILVLLFLPEPARKSKSAASPGAATAAALPWKRVLPIYFLAFLAMLL 212

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462591981 237 YYVAV--FPFiglgkvFFTEKFGFSSQAASAINSVVYVISAPMSPVFGLLVDKTGKNIIWVLCAVAATLvSHMMLAFTMW 314
Cdd:cd17473   213 FYVIPiqLPF------LLQERGGGSAALIGLALAIASLAGAIGALLFGRLKRRLGKRRLLAIGFALMAL-GFLLLALASG 285

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462591981 315 NPWIAMCLL--GLSYSLLACALWPMVAFVVPEHQLGTAYGFMQSIQNLGlAIISIIAGMILDSRGYLFLEVFFIAC 388
Cdd:cd17473   286 LWVVLLGAIlaGLGFGLLLPTLNSWAMSLVPPELRGRAMGIVTSAFFLG-QFLSPLVLGPLVNLTGGLSGAFLILG 360
MFS_MMR_MDR_like cd17504
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ...
 214-375 7.98e-06

Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341047 [Multi-domain]  Cd Length: 371  Bit Score: 47.57  E-value: 7.98e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462591981 214 VIKLTDVKDFSLPLWLI-----FIICVCYYVAVFPFIGLGKVFFTEKFGFSSQAASAINSVVYVISAPMSPVFGLLVDKT 288
Cdd:cd17504   165 LVPLIDLRLLRRRNVLLanitaLLAGFGMFMVFQLLPQLLQLPTPTGFGLGITEAGLLLLPGALVMLIAGPLAGRLIARV 244

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462591981 289 GKNIIwVLCAVAATLVSHMMLAFTMWNPW---IAMCLLGLSYSLLACALWPMVAFVVPEHQLGTAYGFMQSIQNLGLAII 365
Cdd:cd17504   245 GPRRV-LLIGLVISAVGLLLLALLHSSLWalvVALLLIGIGLGLAFASLPNIVVESVPPDRTGIATGMNTVLRTIGSAIG 323

                         170
                  ....*....|
gi 2462591981 366 SIIAGMILDS 375
Cdd:cd17504   324 PAIAGAILTT 333
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 227-387 8.43e-06

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 47.57  E-value: 8.43e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462591981 227 LWLIFIICVCYYVAVFPFIGLgkvfFTEKFGFSSQAASAINSVVYVISAPMSPVFGLLVDKTGKNIIWVLCAVAATLVSH 306
Cdd:cd17325     1 LSLALFLDMLGYGIIIPILPL----YAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTL 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462591981 307 MMLAFTmwNPW---IAMCLLGLSYSLLACALWPMVAFVVPEHQLGTAYGFMQSIQNLGLAIISIIAGMILDSRGYLFleV 383
Cdd:cd17325    77 LFAFAT--SYWqllLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRA--P 152


                  ....
gi 2462591981 384 FFIA 387
Cdd:cd17325   153 FLVC 156
MFS_MT3072_like cd17475
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ...
 87-377 1.17e-05

Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341028 [Multi-domain]  Cd Length: 378  Bit Score: 47.23  E-value: 1.17e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462591981  87 VFALGGIFNAFWLMEFGRFVFGIGGESLAVAQNTYAVSWFKGKELNLVFGLQLSMARIGSTVNMNLMGWLyskieallgs 166
Cdd:cd17475    74 AALLMALVGSYPVLLVLLFLVGAGYGSVQPGGGRAIMRWFPPRERGLAMGIRQTGVPLGGALAAALLPPL---------- 143

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462591981 167 AGHTTLGITLMIGGVTCILSLICALALaYLDQRAERilhKEQGKTGEVIKLTDVKDFSLPLWLIFIICVCYYVAVFPFIG 246
Cdd:cd17475   144 ALHYGWRAAFVVAGLVSILAAVLFWLF-YREPPAAS---AATESASTLLRSLKEVLRNRDVWLIAIAGALLVAPQFALLT 219

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462591981 247 LGKVFFTEKFGFSSQAASAINSVVYVISAPMSPVFGLLVDK--TGKNIIWVLCAVAATLVSHMMLAFTMWNPWIAMCLLG 324
Cdd:cd17475   220 FLLLFLHDHLGLSVVAAGALLAVAQLGGALGRIGLGRVSDRvfGGRRRPVLVITAAIAAAALLVLSLLSPGTPLWLLVLL 299

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2462591981 325 LSYSLLACALW-----PMVAFVVPEHQLGTAYGFMQSIQNLGLAIISIIAGMILDSRG 377
Cdd:cd17475   300 LILLGLFAIGWnglylTLVAESAGPEQAGTALGLANTINFIGIAIGPPLFGLLVDATH 357
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 227-381 1.94e-05

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 46.45  E-value: 1.94e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462591981 227 LWLIFIICVCYYVAVFPFIGLGKVFFTEKFGFSSQAASAINSVVYVISAPMSPVFGLLVDKTGKNIIwVLCAVAATLVSH 306
Cdd:cd17329     1 LWVLLIGSFLNRLGFFMVWPFMAIYLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPV-MLAGLLLRALGF 79

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2462591981 307 MMLAFtMWNPW---IAMCLLGLSYSLLACALWPMVAFVVPEHQLGTAYGFMQSIQNLGLAIISIIAG-MILDSRGYLFL 381
Cdd:cd17329    80 ALLGF-AHSPWlfaIALVLTGFGGGLFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGlLLLYSFRLLFL 157
MFS_NRT2_like cd17341
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ...
 74-388 2.12e-05

Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340899 [Multi-domain]  Cd Length: 384  Bit Score: 46.48  E-value: 2.12e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462591981  74 TIIFSCFVCIGQVVFALGGifNAFWLMEFGRFVFGIGGESLAVAQnTYAVSWFKGKELNLVFGLQLSMARIGSTVNMNLM 153
Cdd:cd17341    67 FIASLLLLLIPLLALALAV--SSYWGLLVLGFLLGFAGANFASGQ-PWASFWFPKEKIGGAAGGIAGAGNMGVAVSQLLA 143

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462591981 154 GWLYSKIEALLGSAGHTtlgitlMIGGVTCILSLICALALAYLDQRAerilhkEQGKTGEVIKLTDVKDfSLPLWLIFII 233
Cdd:cd17341   144 PLIAGAIVFDGGFVGWR------NAFFVPGILLAIAAVLVLLFGDDL------PTGKASALEFLKVQLA-VLKNYRTWIL 210

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462591981 234 CVCYYVAVFPFIGLGKVF---FTEKFGFSSQAASAINSVVYVISAPMSPVFGLLVDKTGKN----IIWVLCAVAATLVSh 306
Cdd:cd17341   211 SLLYGVTFGSFVGFSNVLptyFKTRFGLPLVTAGILAALFPLAGALARPAGGWLSDRFGGRrrlwWLFIVMTIGAALLS- 289

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462591981 307 MMLAFTMWNPWIA---MCLLGLSYSLLACALWPMVAFVVPEhQLGTAYGFMQSIQNLGLAIISIIAGMILDSRG-----Y 378
Cdd:cd17341   290 LSLPTSGTNLVLFlalFVALGLGAGAGNGSVFRMVPFIFRR-ELGAVTGLVGAIGGLGGFFLPLLFGSSALMTGsgvgaF 368

                         330
                  ....*....|
gi 2462591981 379 LFLEVFFIAC 388
Cdd:cd17341   369 SLFGVLAVAC 378
MFS_FEN2_like cd17327
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ...
 51-368 2.93e-05

Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340885 [Multi-domain]  Cd Length: 406  Bit Score: 46.09  E-value: 2.93e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462591981  51 FLGFAIFAMI-ILLPFRLKLNewgtIIFSCFVCIGQVVFALGGIFNAFWLMEFGRFVFGIGGESLAVAQNTYAVSWFKGK 129
Cdd:cd17327    51 YVGYIIFELPgNLLLQRFPPS----KWLSVFIVLWGLLTLLTAAVKNFGGLIALRFFLGLFESGVFPGFILYLGMWYKRE 126

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462591981 130 ELNLVFGLQLSMARIGSTVNmNLMGWLYSKIEALLGSAGHTTLgiTLMIGGVTCILSLICALAL------AYLDQRAERI 203
Cdd:cd17327   127 EQAKRIAFFYAAAGLGSIFG-GLLAYGVFKILGVGGLAGWRWL--FIIEGLITIIIGLVIFFWLpdnpskAWFLTEEEKE 203

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462591981 204 LHKE------QGKTGEVIKLTDVKDF--SLPLWLIFIICVCYYVAVFpFIGLGKVFFTEKFGFSSQAASAINSVVYVISA 275
Cdd:cd17327   204 LAVErlranqTGKGDQKFKWKQIKEAfkDPRTWLLFLFFFCSQITNN-GISNFLPLILKSLGFYSLQTNLLSVPIGALGA 282

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462591981 276 PMSPVFGLLVDKTGKNIIWVLCAVAATLVSHMMLAFTMWNPWI--AMCLLGL-SYSLLACALWPMVAFVVPEHQLGTAYG 352
Cdd:cd17327   283 VSLLIAALLSDRFKKRGLFAIFACVLALVGSIILLAAPNPPGAyfAAYILGGgSYAGFPILLSWISSNCAGYTKRATVLA 362

                         330
                  ....*....|....*.
gi 2462591981 353 FMQSIQNLGLAIISII 368
Cdd:cd17327   363 IMLIFYNVGNIVAPQI 378
MFS_FsR cd17478
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ...
 170-377 5.39e-05

Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341031 [Multi-domain]  Cd Length: 365  Bit Score: 44.85  E-value: 5.39e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462591981 170 TTLGITLMIGGVTCILSLICALALAYLDQRAERILHKEQGKTGEVIKLTD-VKDFSLPLWLIFIICVCYYVAVFPFIGLG 248
Cdd:cd17478   139 AAALVALFGGLGLLILLIIPGLAVALLLLRLRPLKKPEAKKAAAKSSARStLKGVWRALLLLLIIVFLRSWVLSSLTTFL 218

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462591981 249 KVFFTEKfGFSSQAASAINSVVYVISAPMSPVFGLLVDKTG-KNIIWVLCAVAATLvshmMLAFTMWNPWIAMCLLGLSY 327
Cdd:cd17478   219 PFYLVQR-GYSLVFAGLLLSLFLFAGAIGTLIGGPLSDRFGrRRVIIASLLLAAPF----LLLFLLTPGIWSYILLVLAG 293

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2462591981 328 SLLACALWPMVAFV---VPEHqLGTAYGFMQSIQNLGLAIISIIAGMILDSRG 377
Cdd:cd17478   294 FLLFASFPVTVVLAqelLPGN-VGLASGLMMGLSFGLGGIGAPVLGALADAFG 345
MFS_MCT_SLC16 cd17352
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ...
 175-377 9.60e-05

Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340910 [Multi-domain]  Cd Length: 361  Bit Score: 44.08  E-value: 9.60e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462591981 175 TLMIGGVTCILSLICALALAYLDQRAerilhkeqgktgevikltdvkdFSLPLWLIFIICVCYYVavfPFIGLgkVFFTE 254
Cdd:cd17352   159 ALLILGGLCLNLCVCGLLLRLLKDPT----------------------FVLLALGVSFAMLGFFV---PFVYL--PSYAK 211

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462591981 255 KFGFSSQAASAINSVVYVISAPMSPVFGLLVDKTGKNIIWVlCAVAATLVSHMMLAFTMWNPWIAMCLLGLSYSLLACAL 334
Cdd:cd17352   212 SLGIDESDAAFLLSIIGISDIVGRILLGLLADKPRIGRLYL-YIFTLLILGLSLLAFPLATTYVGLIVFSVLFGFCSGSY 290

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 2462591981 335 WPMVAFVVPEH----QLGTAYGFMQSIQNLGLAIISIIAGMILDSRG 377
Cdd:cd17352   291 SSLTPVILADLvgleKLSNAYGLVLLFQGLAALVGPPIAGLLRDYTG 337
MFS_YcaD_like cd17477
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ...
 49-388 1.15e-04

YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341030 [Multi-domain]  Cd Length: 360  Bit Score: 44.09  E-value: 1.15e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462591981  49 MCFLGFAIFAMIILLPFRLKLNEWGTII-------------------------------FSCFVCIGQVVFALGGIFNAF 97
Cdd:cd17477     5 VALLGLGSGLLLPLLSLRLEREGVSTALiglvasayylgillgsplvprlirrvghiraFAAGAAITAVSVLLLALTDSP 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462591981  98 WLMEFGRFVFGIGGESLAVAQNTYAVSWFKGKELNLVFGLQLSMARIGSTVNMNLMGWlyskiealLGSAGHTTLGItlm 177
Cdd:cd17477    85 WVWFLLRFVMGIGLAGLFVVSESWLNALATNENRGRVLGLYSTVLGLGFALGPLLLAL--------VGTAGALPFLI--- 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462591981 178 iggvTCILSLICALALAYLDQRAERILHKEQGKTGEVIKLtdvkdfslpLWLIFIICVCYYVAVFPFIGLGKVFFTEKfG 257
Cdd:cd17477   154 ----AAVLLLLALVPLLLTRRAAPEIEEAESISLRRLLRI---------APLALLGAFVAGFLEGAFYSLLPLYGLRL-G 219

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462591981 258 FSSQAASAINSVVYVISAPMSPVFGLLVDKTGKNIIWVLCAVAATLVShMMLAFTMWNPWIAMCLL----GLSYSLLACA 333
Cdd:cd17477   220 LSVAQAALLLAAFVLGGLLLQWPLGWLADRFDRRRVLLGCALLGALAA-LLLPLVPGLPLALLVLLflwgGAAGPLYTLA 298

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2462591981 334 LwPMVAFVVPEHQLGTAYGFMQSIQNLGLAIISIIAGMILDSRGYLFLEVFFIAC 388
Cdd:cd17477   299 L-ALAGDRLPGDELVAANAALLLLYGLGSVIGPLLAGALMDAFGPHGLFLFLAAV 352
MFS_FsR cd17478
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ...
 251-386 1.63e-04

Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341031 [Multi-domain]  Cd Length: 365  Bit Score: 43.70  E-value: 1.63e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462591981 251 FFTEKFGFSSQAASAINSVVYVISAPMSPVFGLLVDKTGKNiiWVLcaVAATLVSHMMLAFTMWNPWIAMCLLGLSYSLL 330
Cdd:cd17478    21 LLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRR--YLL--PLGPLLTGLGLSLLGFAPNYWLLLLLVALAGI 96

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462591981 331 ACALW----PMVAFVVPEHQLGTAYGFMQSIQNLGLAIISIIAGMILDSRGYLFLEVFFI 386
Cdd:cd17478    97 GSAAFhpegARLASQAAGGRRGLAMSIFSVGGNLGFALGPLIAAALVALFGGLGLLILLI 156
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
228-378 2.99e-04

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 42.95  E-value: 2.99e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462591981 228 WLIFIICVCYYVAVFPFIglgkVFFTEKFGFSSQAASAINSVVYVISAPMSPVFGLLVDKTGKNiIWVLCAVAATLVSHM 307
Cdd:COG2223    11 TLAFFLAFGVWYLWSVLA----PPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPR-RVLLIGLLLLGIGLL 85

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2462591981 308 MLAFTmwNPWIAMCLLGLSYSLLACALW----PMVAFVVPEHQLGTAYGFMQSIQNLGLAIISIIAGMILDSRGY 378
Cdd:COG2223    86 LLALA--VSYWLLLLLGLLLGIGGGGSFavgiALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGW 158
PRK08633 PRK08633
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated
 282-385 9.43e-04

2-acyl-glycerophospho-ethanolamine acyltransferase; Validated


Pssm-ID: 236315 [Multi-domain]  Cd Length: 1146  Bit Score: 41.83  E-value: 9.43e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462591981  282 GLLVDKTGKNIIWVLCAVAATLVSHMM-LAFTMWNPWIAMC---LLGLSYSLLACALWPMVAFVVPEHQLGTAYGFMQSI 357
Cdd:PRK08633    68 GFLADKFSKNRVIRIVKLFEVGLTLLIvLAYYLGWFWLAFAvtfLLGAQSAIYSPAKYGIIPELVGKENLSRANGLLEAF 147

                           90       100
                   ....*....|....*....|....*...
gi 2462591981  358 qnlglAIISIIAGMILDSrgyLFLEVFF 385
Cdd:PRK08633   148 -----TIVAILAGTALFS---FLFESVN 167
MFS_MFSD3 cd17485
Major facilitator superfamily domain containing 3 protein; Major facilitator superfamily ...
 75-388 1.64e-03

Major facilitator superfamily domain containing 3 protein; Major facilitator superfamily domain containing 3 protein (MFSD3) is a predicted acetyl-CoA transporter. As an atypical putative membrane-bound solute carrier (SLC), MFSD3 is most likely to be functionally active in the plasma membrane and not in any intracellular organelles. MFSD3 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341038 [Multi-domain]  Cd Length: 386  Bit Score: 40.29  E-value: 1.64e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462591981  75 IIFSCFVCIGQVVFALGGIFNAFWLMEFGRFVFGIGGESLAVAQNTYAVSWFKGKELNLVFGLQLSMARIGSTVNMNLMG 154
Cdd:cd17485    70 LPTQLGLALLLLALAFLPPTTNLLAFLGLLFLLNLFSATQDIATDGLAVELLTPEERGLGNAAQVVGYKLGSLLGGGGLL 149

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462591981 155 WLYSKIeallgSAGHTTLGITLMIggvtcILSLICALALAYLDQRAERILHKEQGKTGEVIKLTdvkdFSLP--LWLIFI 232
Cdd:cd17485   150 WLYDLI-----GWQSLLLSLAALY-----LLLLLPVLFLRELELPQQPPASERGAALKASLRAF----LRRPgtRWLLLF 215

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462591981 233 IcVCYYVAVFPFIGLGKVFFTEKfGFSSQAASAINSVV-YVISAPMSPVFGLLVDKTGKN---IIWVLCAVAA----TLV 304
Cdd:cd17485   216 L-LLYKLGEQGALAMLPPFLVDR-GFSLSQIGLLSGVGgSLVSIAGSLLGGYLLKRRGRRrllLLGGLLRLLLlglyTLL 293

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462591981 305 SHMMLAFTMWNPWIAMCLLGLSYSLLACALWP-MVAFVVPEHQlGTAYGFMQSIQNLGLAIISIIAGMILDSRGYLFLev 383
Cdd:cd17485   294 ALGGSGLNWVLLLASLALLHLVGGMITTALFTlMMDCSQQAQA-GTDYTLLATVEVLGKLLFGSLAGFLADHLGYAAA-- 370


                  ....*
gi 2462591981 384 FFIAC 388
Cdd:cd17485   371 FLLFA 375
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 74-388 1.69e-03

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 40.29  E-value: 1.69e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462591981  74 TIIFSCFVCIgqVVFALGGIFNAFWLMEFGRFVFGIGGESLAVAQNTYAVSWFKGKELNLVFGLQLSMARIGSTVNMNLM 153
Cdd:cd17329    67 VMLAGLLLRA--LGFALLGFAHSPWLFAIALVLTGFGGGLFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLG 144

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462591981 154 GWLYSkieallgsAGHTTLgitLMIGGVTCILSLICALALAYLDQRAERILHKEQGKTGEVIKLTDVkdfslPLWLIFII 233
Cdd:cd17329   145 GLLLL--------YSFRLL---FLAAAVLFLLAALVLLFLLPETRPKRRAAEKTEILRGYKIVLRDR-----AFLLFLLA 208

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462591981 234 CVCYYVAVFPFIGLGKVFFTEKFGFSSQAAS---AINSVVYVISapMSPVFGLLVDKTGKNIIWV--LCAVAATLVSHMM 308
Cdd:cd17329   209 SFLISLIYFQLESTLPVYVVEILGLGESLLGlllALNALLIVLL--QFPVARLVERFRLRKILMIgiLLFAIGFAVLAFA 286

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462591981 309 LAFTMWnpWIAMCLLGLSYSLLACALWPMVAFVVPEHQLGTAYGFMQSIQNLGLAIISIIAGMILDSRGYLFLEVFFIAC 388
Cdd:cd17329   287 NTLAVL--ILAMIVLTLGEMLVFPAVQTLVAALAPPDKRGSYMGFYALAWGLGRAIGPLVGGLLLDLLGPGLPWLILAAL 364
MFS_KgtP cd17367
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This ...
 188-332 3.03e-03

Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This subfamily includes Escherichia coli alpha-ketoglutarate permease (KgtP) and similar proteins. KgtP is a constitutively expressed proton symporter that functions in the uptake of alpha-ketoglutarate across the boundary membrane. Also included is a putative transporter from Pseudomonas aeruginosa named dicarboxylic acid transporter PcaT. The KgtP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340925 [Multi-domain]  Cd Length: 407  Bit Score: 39.59  E-value: 3.03e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462591981 188 ICALALAYLDQRAERILHKEQGKTGEVIK---LTDVKDFSLPLWLIFIICVCYYVAVFPFIGLGKVFFTEKFGFSSQAAS 264
Cdd:cd17367   183 VLAVVVLWLRRGLEETESFEAIAESNEASagtLRELRRHPRELLLVVGLTAGGTLAFYTWTTYLQKFLVNTAGFSKGDAT 262

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462591981 265 AINSVVYVISAPMSPVFGLLVDKTGKNIIWVLCAVAATLVSHMMLAF--TMWNPWIAMCLLGLSYSLLAC 332
Cdd:cd17367   263 WITTAALLVFMLLQPLGGRLSDRIGRRPLLLFFGIGGTLATVPLLSAldHTDSPYTAFALVLVGLVFLSG 332
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
227-375 4.08e-03

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 39.07  E-value: 4.08e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462591981 227 LWLIFIICVCYYVAVFPFIGLGKV--FFTEKFGFSSQAASAINSVVYVISAPMSPVFGLLVDKTG-KNIIWVLCAVAATL 303
Cdd:COG0738     7 RRALIAIYLLFFLWGFATALWGPLipALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGyKRGLLLGLLLMALG 86

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462591981 304 VSHMMLAFTMWNPWIAMCLLGLSYSLLACALWPMVAFVVPEHQlGTAYGFMQSIQNLGLAIISIIAGMILDS 375
Cdd:COG0738    87 LLLFALAPSYPLLLLALFLLGLGLGLLDVAANPYVAALGPETA-ASRLNLLHAFFSLGALLGPLLGGLLILL 157
MFS_MdfA_MDR_like cd17320
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ...
 81-388 4.85e-03

Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340878 [Multi-domain]  Cd Length: 379  Bit Score: 39.10  E-value: 4.85e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462591981  81 VCIGQVVFALGGIF----NAFWLMEFGRFVFGIGGESLAVAQNTYAVSWFKGKELNLVFGLQLSMARIGSTVNMNLMGWL 156
Cdd:cd17320    67 LLAGLLLFILASLLcalaSSIEQLLIARFLQGLGAAAGSVVARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLL 146

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462591981 157 yskiealLGSAGHTTLGITLMIGGVtcILSLICALALayldqraERILHKEQGKTGEVIKLTDVKD--FSLPLWLIFIIC 234
Cdd:cd17320   147 -------LLFFGWRAIFVFLALLGL--LLLLLVLLFL-------PETLPEEKRKPLLSSLLRAYKRvlKNRRFLGYALAL 210

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462591981 235 VCYYVAVFPFIGLGKVFFTEKFGFSSQAASAINSVVYVISAPMSPVFGLLVDKTG-KNIIWV-----LCAVAATLVSHMM 308
Cdd:cd17320   211 GLSFAGLFAYLAAAPFIYIEQLGLSPAQFGLLFALNAIALILGSLLNGRLVRRFGpRRLLRLgllllLAAALVLLLAALL 290

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462591981 309 LAFTMWNPWIAMCLLGLSYSLL--ACALWPMVAFvvpEHQLGTAYGFMQSIQNLGLAIISIIAGMILDSRGYLFLEVFFI 386
Cdd:cd17320   291 GGLSLWPLVAPLFLIFFGFGLIfpNATSLALEPF---PHVAGTASALLGFLQFLIGALAGALVGLLPNGTALPMGLLILV 367


                  ..
gi 2462591981 387 AC 388
Cdd:cd17320   368 LG 369
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
 227-388 6.06e-03

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 38.71  E-value: 6.06e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462591981 227 LWLIFIICVCYYVAVFPFIGLGKVFFT---EKFGFSSQAASAINSVVYVISAPMSPVFGLLVDKTGKNIIWVLCAVAATL 303
Cdd:cd17330   173 LPPLRRLLLVYFLIALAFAGLESVFSLflkDRFGFSPSQIGLLLALVGIAGILAQLLLIPRLAKRLGERKLLRLGLLLAI 252

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462591981 304 VSHMMLAFtMWNP---WIAMCLLGLSYSLLACALWPMVAFVVPEHQLGTAYGFMQSIQNLGLAIISIIAGMILDSRGYLF 380
Cdd:cd17330   253 IGLLLLPF-ASSVpllVLAAAILAFGTGIVFPALSALLSKSVPSKEQGKAQGIIQSLQSLARIIGPLLAGPLYSFLGPGV 331


                  ....*...
gi 2462591981 381 leVFFIAC 388
Cdd:cd17330   332 --PFLLAA 337
MFS_CsbX cd17337
CsbX family of the Major Facilitator Superfamily of transporters; The CsbX family is composed ...
 238-361 6.28e-03

CsbX family of the Major Facilitator Superfamily of transporters; The CsbX family is composed of Bacillus subtilis CsbX protein (also named alpha-ketoglutarate permease), Klebsiella pneumoniae D-arabinitol transporter (DalT), and similar proteins. The csbX gene is a sigmaB-controlled gene that is expressed during the stationary phase of cell growth. DalT is a pentose-specific ion symporter for D-arabinitol uptake. Most members of this family remain uncharacterized. The CsbX family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340895 [Multi-domain]  Cd Length: 388  Bit Score: 38.64  E-value: 6.28e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462591981 238 YVAVFPFiglgkvFFTEKFGFSSQAASAINSVVYVISAPMSPVFGLLVDKTG--KNIIW---VLCAVAATLVSHMMLAF- 311
Cdd:cd17337   227 FPVFMPL------YFTDTGGFSTSQWLQIWGIIFLVNIFFNLIFGILGDKIGwrRTVRWfggVGCAISTLLFYYVPQLFg 300

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2462591981 312 -TMWNPWIAMCLLGLSyslLAC-----ALWPMVAfvvPEHQlGTAYgfmqSIQNLG 361
Cdd:cd17337   301 hNYWAALIAAILFGIG---LAGfvplsALMPSLA---PEHK-GAAM----SILNLG 345
MFS_ARN_like cd17322
Yeast ARN family of Siderophore iron transporters and similar proteins of the Major ...
 226-376 6.32e-03

Yeast ARN family of Siderophore iron transporters and similar proteins of the Major Facilitator Superfamily; The ARN family of siderophore iron transporters includes ARN1 (or ferrichrome permease), ARN2 (or triacetylfusarinine C transporter 1 or TAF1), ARN3 (or siderophore iron transporter 1 or SIT1 or ferrioxamine B permease) and ARN4 (or Enterobactin permease or ENB1). They specifically recognize siderophore-iron chelates are expressed under conditions of iron deprivation. They facilitate the uptake of both hydroxamate- and catecholate-type siderophores. This group also includes glutathione exchanger 1 (Gex1p) and Gex2p, which are proton/glutathione antiporters that import glutathione from the vacuole and exports it through the plasma membrane. The ARN family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340880 [Multi-domain]  Cd Length: 514  Bit Score: 38.83  E-value: 6.32e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462591981 226 PLWLIFIICVCYYVAVFPFIglgkVFFTEKFGFSSQAASAINSVVYVISAPMSPVFGLLVDKTGKNIIWV-----LCAVA 300
Cdd:cd17322   290 ACLIDFFYFFSYYIFSDYLY----TVLQVAVGESITSATRITNLYSFVSTVAGIFVGFLIRKTRRYKVLViigvpLYIVG 365

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2462591981 301 ATLVSHMMLAFTMWNPWI-AMCLLGLSYSLLACALWPMVAFVVPEHQLGTAYGFMQSIQNLGLAIISIIAGMILDSR 376
Cdd:cd17322   366 MGLLIRYRGGSGSHGGIIgALILIGIGGGLFTYPVQVSVQASVSHQEMAVVTALLLTVYSIGGAVGAAISGAIWTQT 442
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH