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Conserved domains on  [gi|2462592035|ref|XP_054203570|]
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fibronectin type III domain-containing protein 3B isoform X1 [Homo sapiens]

Protein Classification

fibronectin type III domain-containing protein( domain architecture ID 10047016)

fibronectin type III (FN3) domain-containing protein may be involved in specific interactions with other molecules through its FN3 domain; similar to fibronectin type-III domain-containing protein 3A/3B

Gene Ontology:  GO:0005515
PubMed:  8981327

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
537-867 1.55e-20

Fibronectin type 3 domain [General function prediction only];


:

Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 97.38  E-value: 1.55e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462592035  537 NLKRSTQYKFRLTASNTEGKSCPSEVLVCTTSPDRPGPPTrPLVKGPVTSHGFSVKWDPPKDNGGSEilkYLLEItdGNS 616
Cdd:COG3401    198 DIEPGTTYYYRVAATDTGGESAPSNEVSVTTPTTPPSAPT-GLTATADTPGSVTLSWDPVTESDATG---YRVYR--SNS 271

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462592035  617 EANQWEVAYSGSATEYTFTHLKPGT--LYKLRAcCISTGGHSQCSESLPVRTLSIAPGqcrPPRVL--GRPKHKEVHLEW 692
Cdd:COG3401    272 GDGPFTKVATVTTTSYTDTGLTNGTtyYYRVTA-VDAAGNESAPSNVVSVTTDLTPPA---APSGLtaTAVGSSSITLSW 347

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462592035  693 DvPASESGceVSEYSVEMTEPEDVASEVYH--GPELECTVGNLLPGTVYRFRVRALNDGG-YGPYSD-VSEITTAAGPPG 768
Cdd:COG3401    348 T-ASSDAD--VTGYNVYRSTSGGGTYTKIAetVTTTSYTDTGLTPGTTYYYKVTAVDAAGnESAPSEeVSATTASAASGE 424

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462592035  769 QCKAPCISCTPDGCVLVGWESPDSSGADISEYRLEWGEDEESLELiyHGTDTRFEIRDLLPAAQYCCRLQAFNQAGAGPY 848
Cdd:COG3401    425 SLTASVDAVPLTDVAGATAAASAASNPGVSAAVLADGGDTGNAVP--FTTTSSTVTATTTDTTTANLSVTTGSLVGGSGA 502

                          330
                   ....*....|....*....
gi 2462592035  849 SELVLCQTPASAPDPVSTL 867
Cdd:COG3401    503 SSVTNSVSVIGASAAAAVG 521
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
729-1063 1.04e-16

Fibronectin type 3 domain [General function prediction only];


:

Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 85.05  E-value: 1.04e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462592035  729 TVGNLLPGTVYRFRVRALNDGGYGPYSDVSEITTAAGPPGqckAPC----ISCTPDGcVLVGWESPDSSGADisEYRLEW 804
Cdd:COG3401    195 GGGDIEPGTTYYYRVAATDTGGESAPSNEVSVTTPTTPPS---APTgltaTADTPGS-VTLSWDPVTESDAT--GYRVYR 268

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462592035  805 GEDE-ESLELIYHGTDTRFEIRDLLPAAQYCCRLQAFNQAG-AGPYSELVLCQTPASAPDPVSTlcvleeepLDAYPDSP 882
Cdd:COG3401    269 SNSGdGPFTKVATVTTTSYTDTGLTNGTTYYYRVTAVDAAGnESAPSNVVSVTTDLTPPAAPSG--------LTATAVGS 340

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462592035  883 SAcLVLNWEEpcNNGSEILAYTI------DLGDTSI-TVGNTTMHVMKDLLPETTYRIRIQAINEIG-AGPFSQFIKAKT 954
Cdd:COG3401    341 SS-ITLSWTA--SSDADVTGYNVyrstsgGGTYTKIaETVTTTSYTDTGLTPGTTYYYKVTAVDAAGnESAPSEEVSATT 417

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462592035  955 RPLPPLPPRLECAAAGPQSLKLKWGDSNSKTHAAEDIVYTLQLEDRNKRFISIYRGPSHTYKVQRLTEFTCYSFRIQAAS 1034
Cdd:COG3401    418 ASAASGESLTASVDAVPLTDVAGATAAASAASNPGVSAAVLADGGDTGNAVPFTTTSSTVTATTTDTTTANLSVTTGSLV 497

                          330       340
                   ....*....|....*....|....*....
gi 2462592035 1035 eAGEGPFSETYTFSTTKSVPPTIKAPRVT 1063
Cdd:COG3401    498 -GGSGASSVTNSVSVIGASAAAAVGGAPD 525
FN3 super family cl27307
Fibronectin type 3 domain [General function prediction only];
347-643 1.45e-13

Fibronectin type 3 domain [General function prediction only];


The actual alignment was detected with superfamily member COG3401:

Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 75.04  E-value: 1.45e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462592035  347 PATDYHVRVYAMYNSVKGSCSEPVSFTTHSCAPECPFPPKLAHRSKSSLTLQWKAPIDNGskITNYLLEWDEGKrNSGFR 426
Cdd:COG3401    201 PGTTYYYRVAATDTGGESAPSNEVSVTTPTTPPSAPTGLTATADTPGSVTLSWDPVTESD--ATGYRVYRSNSG-DGPFT 277

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462592035  427 QCFFGSQKHCKLTKLCPAMGYTFRLAARNDIGT-SGYSQEVVCYTLGNIPQMPSAPRLVRAGITWVTLQWSKPegcSPEE 505
Cdd:COG3401    278 KVATVTTTSYTDTGLTNGTTYYYRVTAVDAAGNeSAPSNVVSVTTDLTPPAAPSGLTATAVGSSSITLSWTAS---SDAD 354

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462592035  506 VITYTLEIQEDENDNLFHPKYTGEDLTCTVKNLKRSTQYKFRLTASNTEG-KSCPSEVLVCTTSPDRPGPPT---RPLVK 581
Cdd:COG3401    355 VTGYNVYRSTSGGGTYTKIAETVTTTSYTDTGLTPGTTYYYKVTAVDAAGnESAPSEEVSATTASAASGESLtasVDAVP 434

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462592035  582 GPVTSHGFSVKWDPPKDNGGSEILKYLLEITDGNSEANQWEVAYSGSATEYTFTHLKPGTLY 643
Cdd:COG3401    435 LTDVAGATAAASAASNPGVSAAVLADGGDTGNAVPFTTTSSTVTATTTDTTTANLSVTTGSL 496
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 280-374 3.27e-08

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 52.11  E-value: 3.27e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462592035  280 EKPQVSNIQARAVVLSWAPPVGLScGPHSGlsfpysYEVALSDKGRDGKYKI-IYSGEELECNLKDLRPATDYHVRVYAM 358
Cdd:cd00063      5 TNLRVTDVTSTSVTLSWTPPEDDG-GPITG------YVVEYREKGSGDWKEVeVTPGSETSYTLTGLKPGTEYEFRVRAV 77

                           90
                   ....*....|....*.
gi 2462592035  359 YNSVKGSCSEPVSFTT 374
Cdd:cd00063     78 NGGGESPPSESVTVTT 93
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1054-1127 6.23e-07

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 48.65  E-value: 6.23e-07
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462592035 1054 PPTIKAPRVTQLEGNSCEILWETVPSMKGDPVNYILQVLVGRESEYKQVYK--GEEATFQISGLQTNTDYRFRVCA 1127
Cdd:cd00063      1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSGDWKEVEVtpGSETSYTLTGLKPGTEYEFRVRA 76
 
Name Accession Description Interval E-value
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
537-867 1.55e-20

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 97.38  E-value: 1.55e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462592035  537 NLKRSTQYKFRLTASNTEGKSCPSEVLVCTTSPDRPGPPTrPLVKGPVTSHGFSVKWDPPKDNGGSEilkYLLEItdGNS 616
Cdd:COG3401    198 DIEPGTTYYYRVAATDTGGESAPSNEVSVTTPTTPPSAPT-GLTATADTPGSVTLSWDPVTESDATG---YRVYR--SNS 271

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462592035  617 EANQWEVAYSGSATEYTFTHLKPGT--LYKLRAcCISTGGHSQCSESLPVRTLSIAPGqcrPPRVL--GRPKHKEVHLEW 692
Cdd:COG3401    272 GDGPFTKVATVTTTSYTDTGLTNGTtyYYRVTA-VDAAGNESAPSNVVSVTTDLTPPA---APSGLtaTAVGSSSITLSW 347

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462592035  693 DvPASESGceVSEYSVEMTEPEDVASEVYH--GPELECTVGNLLPGTVYRFRVRALNDGG-YGPYSD-VSEITTAAGPPG 768
Cdd:COG3401    348 T-ASSDAD--VTGYNVYRSTSGGGTYTKIAetVTTTSYTDTGLTPGTTYYYKVTAVDAAGnESAPSEeVSATTASAASGE 424

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462592035  769 QCKAPCISCTPDGCVLVGWESPDSSGADISEYRLEWGEDEESLELiyHGTDTRFEIRDLLPAAQYCCRLQAFNQAGAGPY 848
Cdd:COG3401    425 SLTASVDAVPLTDVAGATAAASAASNPGVSAAVLADGGDTGNAVP--FTTTSSTVTATTTDTTTANLSVTTGSLVGGSGA 502

                          330
                   ....*....|....*....
gi 2462592035  849 SELVLCQTPASAPDPVSTL 867
Cdd:COG3401    503 SSVTNSVSVIGASAAAAVG 521
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
729-1063 1.04e-16

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 85.05  E-value: 1.04e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462592035  729 TVGNLLPGTVYRFRVRALNDGGYGPYSDVSEITTAAGPPGqckAPC----ISCTPDGcVLVGWESPDSSGADisEYRLEW 804
Cdd:COG3401    195 GGGDIEPGTTYYYRVAATDTGGESAPSNEVSVTTPTTPPS---APTgltaTADTPGS-VTLSWDPVTESDAT--GYRVYR 268

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462592035  805 GEDE-ESLELIYHGTDTRFEIRDLLPAAQYCCRLQAFNQAG-AGPYSELVLCQTPASAPDPVSTlcvleeepLDAYPDSP 882
Cdd:COG3401    269 SNSGdGPFTKVATVTTTSYTDTGLTNGTTYYYRVTAVDAAGnESAPSNVVSVTTDLTPPAAPSG--------LTATAVGS 340

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462592035  883 SAcLVLNWEEpcNNGSEILAYTI------DLGDTSI-TVGNTTMHVMKDLLPETTYRIRIQAINEIG-AGPFSQFIKAKT 954
Cdd:COG3401    341 SS-ITLSWTA--SSDADVTGYNVyrstsgGGTYTKIaETVTTTSYTDTGLTPGTTYYYKVTAVDAAGnESAPSEEVSATT 417

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462592035  955 RPLPPLPPRLECAAAGPQSLKLKWGDSNSKTHAAEDIVYTLQLEDRNKRFISIYRGPSHTYKVQRLTEFTCYSFRIQAAS 1034
Cdd:COG3401    418 ASAASGESLTASVDAVPLTDVAGATAAASAASNPGVSAAVLADGGDTGNAVPFTTTSSTVTATTTDTTTANLSVTTGSLV 497

                          330       340
                   ....*....|....*....|....*....
gi 2462592035 1035 eAGEGPFSETYTFSTTKSVPPTIKAPRVT 1063
Cdd:COG3401    498 -GGSGASSVTNSVSVIGASAAAAVGGAPD 525
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 572-666 7.97e-14

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 68.29  E-value: 7.97e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462592035  572 PGPPTRPLVKgPVTSHGFSVKWDPPKDNGGsEILKYLLEITDGNSEANQWEVAYSGSATEYTFTHLKPGTLYKLRACCIS 651
Cdd:cd00063      1 PSPPTNLRVT-DVTSTSVTLSWTPPEDDGG-PITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVN 78

                           90
                   ....*....|....*
gi 2462592035  652 TGGHSQCSESLPVRT 666
Cdd:cd00063     79 GGGESPPSESVTVTT 93
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
347-643 1.45e-13

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 75.04  E-value: 1.45e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462592035  347 PATDYHVRVYAMYNSVKGSCSEPVSFTTHSCAPECPFPPKLAHRSKSSLTLQWKAPIDNGskITNYLLEWDEGKrNSGFR 426
Cdd:COG3401    201 PGTTYYYRVAATDTGGESAPSNEVSVTTPTTPPSAPTGLTATADTPGSVTLSWDPVTESD--ATGYRVYRSNSG-DGPFT 277

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462592035  427 QCFFGSQKHCKLTKLCPAMGYTFRLAARNDIGT-SGYSQEVVCYTLGNIPQMPSAPRLVRAGITWVTLQWSKPegcSPEE 505
Cdd:COG3401    278 KVATVTTTSYTDTGLTNGTTYYYRVTAVDAAGNeSAPSNVVSVTTDLTPPAAPSGLTATAVGSSSITLSWTAS---SDAD 354

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462592035  506 VITYTLEIQEDENDNLFHPKYTGEDLTCTVKNLKRSTQYKFRLTASNTEG-KSCPSEVLVCTTSPDRPGPPT---RPLVK 581
Cdd:COG3401    355 VTGYNVYRSTSGGGTYTKIAETVTTTSYTDTGLTPGTTYYYKVTAVDAAGnESAPSEEVSATTASAASGESLtasVDAVP 434

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462592035  582 GPVTSHGFSVKWDPPKDNGGSEILKYLLEITDGNSEANQWEVAYSGSATEYTFTHLKPGTLY 643
Cdd:COG3401    435 LTDVAGATAAASAASNPGVSAAVLADGGDTGNAVPFTTTSSTVTATTTDTTTANLSVTTGSL 496
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 478-567 3.96e-12

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 63.28  E-value: 3.96e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462592035  478 PSAPRLVRA---GITWVTLQWSKPEGcSPEEVITYTLEIQEDENDNLFH-PKYTGEDLTCTVKNLKRSTQYKFRLTASNT 553
Cdd:cd00063      1 PSPPTNLRVtdvTSTSVTLSWTPPED-DGGPITGYVVEYREKGSGDWKEvEVTPGSETSYTLTGLKPGTEYEFRVRAVNG 79

                           90
                   ....*....|....
gi 2462592035  554 EGKSCPSEVLVCTT 567
Cdd:cd00063     80 GGESPPSESVTVTT 93
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 572-656 4.05e-12

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 63.02  E-value: 4.05e-12
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462592035   572 PGPPTRPLVKgPVTSHGFSVKWDPPK-DNGGSEILKYllEITDGNSEANQWEVAYSGSATEYTFTHLKPGTLYKLRACCI 650
Cdd:smart00060    1 PSPPSNLRVT-DVTSTSVTLSWEPPPdDGITGYIVGY--RVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAV 77


                    ....*.
gi 2462592035   651 STGGHS 656
Cdd:smart00060   78 NGAGEG 83
fn3 pfam00041
Fibronectin type III domain;
382-463 7.34e-11

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 59.35  E-value: 7.34e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462592035  382 PFPPKLAHRSKSSLTLQWKAPIDNGSKITNYLLEWDEGKRNSGFRQCF-FGSQKHCKLTKLCPAMGYTFRLAARNDIGTS 460
Cdd:pfam00041    3 PSNLTVTDVTSTSLTVSWTPPPDGNGPITGYEVEYRPKNSGEPWNEITvPGTTTSVTLTGLKPGTEYEVRVQAVNGGGEG 82


                   ...
gi 2462592035  461 GYS 463
Cdd:pfam00041   83 PPS 85
fn3 pfam00041
Fibronectin type III domain;
573-657 1.59e-10

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 58.58  E-value: 1.59e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462592035  573 GPPTRPLVKgPVTSHGFSVKWDPPKDnGGSEILKYLLEITDGNSEANQWEVAYSGSATEYTFTHLKPGTLYKLRACCIST 652
Cdd:pfam00041    1 SAPSNLTVT-DVTSTSLTVSWTPPPD-GNGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNG 78


                   ....*
gi 2462592035  653 GGHSQ 657
Cdd:pfam00041   79 GGEGP 83
fn3 pfam00041
Fibronectin type III domain;
886-947 5.17e-10

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 57.04  E-value: 5.17e-10
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462592035  886 LVLNWEEPCNNGSEILAYTIDL-------GDTSITVGNTTMHVM-KDLLPETTYRIRIQAINEIGAGPFS 947
Cdd:pfam00041   16 LTVSWTPPPDGNGPITGYEVEYrpknsgePWNEITVPGTTTSVTlTGLKPGTEYEVRVQAVNGGGEGPPS 85
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 886-954 4.18e-09

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 54.81  E-value: 4.18e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2462592035  886 LVLNWEEPCNNGSEILAYTIDLGDTS--------ITVGNTTMHVMKDLLPETTYRIRIQAINEIGAGPFSQFIKAKT 954
Cdd:cd00063     17 VTLSWTPPEDDGGPITGYVVEYREKGsgdwkeveVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGESPPSESVTVTT 93
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 280-374 3.27e-08

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 52.11  E-value: 3.27e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462592035  280 EKPQVSNIQARAVVLSWAPPVGLScGPHSGlsfpysYEVALSDKGRDGKYKI-IYSGEELECNLKDLRPATDYHVRVYAM 358
Cdd:cd00063      5 TNLRVTDVTSTSVTLSWTPPEDDG-GPITG------YVVEYREKGSGDWKEVeVTPGSETSYTLTGLKPGTEYEFRVRAV 77

                           90
                   ....*....|....*.
gi 2462592035  359 YNSVKGSCSEPVSFTT 374
Cdd:cd00063     78 NGGGESPPSESVTVTT 93
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 379-460 5.01e-08

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 51.46  E-value: 5.01e-08
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462592035   379 PECPFPPKLAHRSKSSLTLQWKAPIDNG--SKITNYLLEWDEgKRNSGFRQCFFGSQKHCKLTKLCPAMGYTFRLAARND 456
Cdd:smart00060    1 PSPPSNLRVTDVTSTSVTLSWEPPPDDGitGYIVGYRVEYRE-EGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNG 79


                    ....
gi 2462592035   457 IGTS 460
Cdd:smart00060   80 AGEG 83
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1054-1127 6.23e-07

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 48.65  E-value: 6.23e-07
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462592035 1054 PPTIKAPRVTQLEGNSCEILWETVPSMKGDPVNYILQVLVGRESEYKQVYK--GEEATFQISGLQTNTDYRFRVCA 1127
Cdd:cd00063      1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSGDWKEVEVtpGSETSYTLTGLKPGTEYEFRVRA 76
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 280-357 1.01e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 47.61  E-value: 1.01e-06
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2462592035   280 EKPQVSNIQARAVVLSWAPPVglscgPHSGLSFPYSYEVALSDKGRDGKyKIIYSGEELECNLKDLRPATDYHVRVYA 357
Cdd:smart00060    5 SNLRVTDVTSTSVTLSWEPPP-----DDGITGYIVGYRVEYREEGSEWK-EVNVTPSSTSYTLTGLKPGTEYEFRVRA 76
fn3 pfam00041
Fibronectin type III domain;
282-357 1.73e-06

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 47.02  E-value: 1.73e-06
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462592035  282 PQVSNIQARAVVLSWAPPVGLScGPHSGlsfpYSYEVALSDKGRDGKYKIIySGEELECNLKDLRPATDYHVRVYA 357
Cdd:pfam00041    6 LTVTDVTSTSLTVSWTPPPDGN-GPITG----YEVEYRPKNSGEPWNEITV-PGTTTSVTLTGLKPGTEYEVRVQA 75
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
1014-1127 4.55e-06

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 50.77  E-value: 4.55e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462592035 1014 TYKVQRLTEFTCYSFRIQAASEAGEGPFSETYTFsTTKSVPPTikAP---RVTQLEGNSCEILWETVPSMkgDPVNYILQ 1090
Cdd:COG3401    193 VDGGGDIEPGTTYYYRVAATDTGGESAPSNEVSV-TTPTTPPS--APtglTATADTPGSVTLSWDPVTES--DATGYRVY 267

                           90       100       110
                   ....*....|....*....|....*....|....*..
gi 2462592035 1091 VLVGRESEYKQVYKGEEATFQISGLQTNTDYRFRVCA 1127
Cdd:COG3401    268 RSNSGDGPFTKVATVTTTSYTDTGLTNGTTYYYRVTA 304
fn3 pfam00041
Fibronectin type III domain;
1054-1127 5.94e-06

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 45.48  E-value: 5.94e-06
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462592035 1054 PPTIkaPRVTQLEGNSCEILWETVPSMKGDPVNYILQVLVGRESEYKQVY--KGEEATFQISGLQTNTDYRFRVCA 1127
Cdd:pfam00041    2 APSN--LTVTDVTSTSLTVSWTPPPDGNGPITGYEVEYRPKNSGEPWNEItvPGTTTSVTLTGLKPGTEYEVRVQA 75
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 861-944 6.59e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 45.30  E-value: 6.59e-06
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462592035   861 PDPVSTLCVLeeepldaypDSPSACLVLNWEEP--CNNGSEILAYTIDLGDTS------ITVGNTTMHVMKDLLPETTYR 932
Cdd:smart00060    1 PSPPSNLRVT---------DVTSTSVTLSWEPPpdDGITGYIVGYRVEYREEGsewkevNVTPSSTSYTLTGLKPGTEYE 71

                            90
                    ....*....|..
gi 2462592035   933 IRIQAINEIGAG 944
Cdd:smart00060   72 FRVRAVNGAGEG 83
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1054-1127 2.49e-04

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 41.06  E-value: 2.49e-04
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2462592035  1054 PPTIKAPRVTQLEGNSCEILWETVPSmkGDPVNYILQVLV---GRESEYKQVYKGEEAT-FQISGLQTNTDYRFRVCA 1127
Cdd:smart00060    1 PSPPSNLRVTDVTSTSVTLSWEPPPD--DGITGYIVGYRVeyrEEGSEWKEVNVTPSSTsYTLTGLKPGTEYEFRVRA 76
 
Name Accession Description Interval E-value
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
537-867 1.55e-20

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 97.38  E-value: 1.55e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462592035  537 NLKRSTQYKFRLTASNTEGKSCPSEVLVCTTSPDRPGPPTrPLVKGPVTSHGFSVKWDPPKDNGGSEilkYLLEItdGNS 616
Cdd:COG3401    198 DIEPGTTYYYRVAATDTGGESAPSNEVSVTTPTTPPSAPT-GLTATADTPGSVTLSWDPVTESDATG---YRVYR--SNS 271

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462592035  617 EANQWEVAYSGSATEYTFTHLKPGT--LYKLRAcCISTGGHSQCSESLPVRTLSIAPGqcrPPRVL--GRPKHKEVHLEW 692
Cdd:COG3401    272 GDGPFTKVATVTTTSYTDTGLTNGTtyYYRVTA-VDAAGNESAPSNVVSVTTDLTPPA---APSGLtaTAVGSSSITLSW 347

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462592035  693 DvPASESGceVSEYSVEMTEPEDVASEVYH--GPELECTVGNLLPGTVYRFRVRALNDGG-YGPYSD-VSEITTAAGPPG 768
Cdd:COG3401    348 T-ASSDAD--VTGYNVYRSTSGGGTYTKIAetVTTTSYTDTGLTPGTTYYYKVTAVDAAGnESAPSEeVSATTASAASGE 424

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462592035  769 QCKAPCISCTPDGCVLVGWESPDSSGADISEYRLEWGEDEESLELiyHGTDTRFEIRDLLPAAQYCCRLQAFNQAGAGPY 848
Cdd:COG3401    425 SLTASVDAVPLTDVAGATAAASAASNPGVSAAVLADGGDTGNAVP--FTTTSSTVTATTTDTTTANLSVTTGSLVGGSGA 502

                          330
                   ....*....|....*....
gi 2462592035  849 SELVLCQTPASAPDPVSTL 867
Cdd:COG3401    503 SSVTNSVSVIGASAAAAVG 521
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
566-948 1.51e-19

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 94.30  E-value: 1.51e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462592035  566 TTSPDRPGPPTRPLVKGPVTSHGFSVKWDPPKDNGGSEILKYLLEITDGNSEANQWEVAYSGSATEYTFTHLKPGTLYKL 645
Cdd:COG3401    128 ATAVAGGAATAGTYALGAGLYGVDGANASGTTASSVAGAGVVVSPDTSATAAVATTSLTVTSTTLVDGGGDIEPGTTYYY 207

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462592035  646 RACCISTGGHSQCSESLPVRTLSIAPGQcrPPRVLGRPK-HKEVHLEWDvPASESGceVSEYSVEMTEPEDVA-SEVYHG 723
Cdd:COG3401    208 RVAATDTGGESAPSNEVSVTTPTTPPSA--PTGLTATADtPGSVTLSWD-PVTESD--ATGYRVYRSNSGDGPfTKVATV 282

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462592035  724 PELECTVGNLLPGTVYRFRVRALN-DGGYGPYSDVSEITTAAGPPGqckAP----CISCTPDGCVLvGWEspDSSGADIS 798
Cdd:COG3401    283 TTTSYTDTGLTNGTTYYYRVTAVDaAGNESAPSNVVSVTTDLTPPA---APsgltATAVGSSSITL-SWT--ASSDADVT 356

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462592035  799 EYRLEWGEDEE-SLELIYHG-TDTRFEIRDLLPAAQYCCRLQAFNQAG-AGPYSELVLcQTPASAPDPVSTLCVLEEEPL 875
Cdd:COG3401    357 GYNVYRSTSGGgTYTKIAETvTTTSYTDTGLTPGTTYYYKVTAVDAAGnESAPSEEVS-ATTASAASGESLTASVDAVPL 435

                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462592035  876 DAYPDSPSACLVLNWeepcNNGSEILAYTIDLGDTSITVGNTTMHVMKDLLPETTYRIRIQAINEIGAGPFSQ 948
Cdd:COG3401    436 TDVAGATAAASAASN----PGVSAAVLADGGDTGNAVPFTTTSSTVTATTTDTTTANLSVTTGSLVGGSGASS 504
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
447-672 7.83e-17

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 85.44  E-value: 7.83e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462592035  447 YTFRLAARNDIGTSGYSQEVVCYTLGNIPQMPSAPRLVRAGITWVTLQWSKPEGcspEEVITYTLEIQEDENDNlFHPKY 526
Cdd:COG3401    205 YYYRVAATDTGGESAPSNEVSVTTPTTPPSAPTGLTATADTPGSVTLSWDPVTE---SDATGYRVYRSNSGDGP-FTKVA 280

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462592035  527 TGEDLTCTVKNLKRSTQYKFRLTASNTEG-KSCPSEVLVCTTSPDRPGPPTrPLVKGPVTSHGFSVKWDPPKDNGgseIL 605
Cdd:COG3401    281 TVTTTSYTDTGLTNGTTYYYRVTAVDAAGnESAPSNVVSVTTDLTPPAAPS-GLTATAVGSSSITLSWTASSDAD---VT 356

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462592035  606 KYLLEItdGNSEANQWE-VAYSGSATEYTFTHLKPGT--LYKLRAcCISTGGHSQCSESLPVRTLSIAPG 672
Cdd:COG3401    357 GYNVYR--STSGGGTYTkIAETVTTTSYTDTGLTPGTtyYYKVTA-VDAAGNESAPSEEVSATTASAASG 423
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
729-1063 1.04e-16

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 85.05  E-value: 1.04e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462592035  729 TVGNLLPGTVYRFRVRALNDGGYGPYSDVSEITTAAGPPGqckAPC----ISCTPDGcVLVGWESPDSSGADisEYRLEW 804
Cdd:COG3401    195 GGGDIEPGTTYYYRVAATDTGGESAPSNEVSVTTPTTPPS---APTgltaTADTPGS-VTLSWDPVTESDAT--GYRVYR 268

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462592035  805 GEDE-ESLELIYHGTDTRFEIRDLLPAAQYCCRLQAFNQAG-AGPYSELVLCQTPASAPDPVSTlcvleeepLDAYPDSP 882
Cdd:COG3401    269 SNSGdGPFTKVATVTTTSYTDTGLTNGTTYYYRVTAVDAAGnESAPSNVVSVTTDLTPPAAPSG--------LTATAVGS 340

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462592035  883 SAcLVLNWEEpcNNGSEILAYTI------DLGDTSI-TVGNTTMHVMKDLLPETTYRIRIQAINEIG-AGPFSQFIKAKT 954
Cdd:COG3401    341 SS-ITLSWTA--SSDADVTGYNVyrstsgGGTYTKIaETVTTTSYTDTGLTPGTTYYYKVTAVDAAGnESAPSEEVSATT 417

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462592035  955 RPLPPLPPRLECAAAGPQSLKLKWGDSNSKTHAAEDIVYTLQLEDRNKRFISIYRGPSHTYKVQRLTEFTCYSFRIQAAS 1034
Cdd:COG3401    418 ASAASGESLTASVDAVPLTDVAGATAAASAASNPGVSAAVLADGGDTGNAVPFTTTSSTVTATTTDTTTANLSVTTGSLV 497

                          330       340
                   ....*....|....*....|....*....
gi 2462592035 1035 eAGEGPFSETYTFSTTKSVPPTIKAPRVT 1063
Cdd:COG3401    498 -GGSGASSVTNSVSVIGASAAAAVGGAPD 525
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 572-666 7.97e-14

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 68.29  E-value: 7.97e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462592035  572 PGPPTRPLVKgPVTSHGFSVKWDPPKDNGGsEILKYLLEITDGNSEANQWEVAYSGSATEYTFTHLKPGTLYKLRACCIS 651
Cdd:cd00063      1 PSPPTNLRVT-DVTSTSVTLSWTPPEDDGG-PITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVN 78

                           90
                   ....*....|....*
gi 2462592035  652 TGGHSQCSESLPVRT 666
Cdd:cd00063     79 GGGESPPSESVTVTT 93
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
347-643 1.45e-13

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 75.04  E-value: 1.45e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462592035  347 PATDYHVRVYAMYNSVKGSCSEPVSFTTHSCAPECPFPPKLAHRSKSSLTLQWKAPIDNGskITNYLLEWDEGKrNSGFR 426
Cdd:COG3401    201 PGTTYYYRVAATDTGGESAPSNEVSVTTPTTPPSAPTGLTATADTPGSVTLSWDPVTESD--ATGYRVYRSNSG-DGPFT 277

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462592035  427 QCFFGSQKHCKLTKLCPAMGYTFRLAARNDIGT-SGYSQEVVCYTLGNIPQMPSAPRLVRAGITWVTLQWSKPegcSPEE 505
Cdd:COG3401    278 KVATVTTTSYTDTGLTNGTTYYYRVTAVDAAGNeSAPSNVVSVTTDLTPPAAPSGLTATAVGSSSITLSWTAS---SDAD 354

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462592035  506 VITYTLEIQEDENDNLFHPKYTGEDLTCTVKNLKRSTQYKFRLTASNTEG-KSCPSEVLVCTTSPDRPGPPT---RPLVK 581
Cdd:COG3401    355 VTGYNVYRSTSGGGTYTKIAETVTTTSYTDTGLTPGTTYYYKVTAVDAAGnESAPSEEVSATTASAASGESLtasVDAVP 434

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462592035  582 GPVTSHGFSVKWDPPKDNGGSEILKYLLEITDGNSEANQWEVAYSGSATEYTFTHLKPGTLY 643
Cdd:COG3401    435 LTDVAGATAAASAASNPGVSAAVLADGGDTGNAVPFTTTSSTVTATTTDTTTANLSVTTGSL 496
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 671-762 2.01e-13

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 67.14  E-value: 2.01e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462592035  671 PGQCRPPRVLGRPKHkEVHLEWDVPASESGcEVSEYSVEMTEPEDVASEVY---HGPELECTVGNLLPGTVYRFRVRALN 747
Cdd:cd00063      1 PSPPTNLRVTDVTST-SVTLSWTPPEDDGG-PITGYVVEYREKGSGDWKEVevtPGSETSYTLTGLKPGTEYEFRVRAVN 78

                           90
                   ....*....|....*
gi 2462592035  748 DGGYGPYSDVSEITT 762
Cdd:cd00063     79 GGGESPPSESVTVTT 93
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 478-567 3.96e-12

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 63.28  E-value: 3.96e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462592035  478 PSAPRLVRA---GITWVTLQWSKPEGcSPEEVITYTLEIQEDENDNLFH-PKYTGEDLTCTVKNLKRSTQYKFRLTASNT 553
Cdd:cd00063      1 PSPPTNLRVtdvTSTSVTLSWTPPED-DGGPITGYVVEYREKGSGDWKEvEVTPGSETSYTLTGLKPGTEYEFRVRAVNG 79

                           90
                   ....*....|....
gi 2462592035  554 EGKSCPSEVLVCTT 567
Cdd:cd00063     80 GGESPPSESVTVTT 93
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 572-656 4.05e-12

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 63.02  E-value: 4.05e-12
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462592035   572 PGPPTRPLVKgPVTSHGFSVKWDPPK-DNGGSEILKYllEITDGNSEANQWEVAYSGSATEYTFTHLKPGTLYKLRACCI 650
Cdd:smart00060    1 PSPPSNLRVT-DVTSTSVTLSWEPPPdDGITGYIVGY--RVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAV 77


                    ....*.
gi 2462592035   651 STGGHS 656
Cdd:smart00060   78 NGAGEG 83
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 379-470 8.90e-12

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 62.51  E-value: 8.90e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462592035  379 PECPFPPKLAHRSKSSLTLQWKAPIDNGSKITNYLLEWDEgKRNSGFRQC--FFGSQKHCKLTKLCPAMGYTFRLAARND 456
Cdd:cd00063      1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYRE-KGSGDWKEVevTPGSETSYTLTGLKPGTEYEFRVRAVNG 79

                           90
                   ....*....|....
gi 2462592035  457 IGTSGYSQEVVCYT 470
Cdd:cd00063     80 GGESPPSESVTVTT 93
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
927-1127 4.08e-11

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 67.33  E-value: 4.08e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462592035  927 PETTYRIRIQAINEIGAGPFSQFIKAKTRPLPPLPPRL-ECAAAGPQSLKLKWgDSNSKTHAAEDIVYtlQLEDRNKRFI 1005
Cdd:COG3401    201 PGTTYYYRVAATDTGGESAPSNEVSVTTPTTPPSAPTGlTATADTPGSVTLSW-DPVTESDATGYRVY--RSNSGDGPFT 277

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462592035 1006 SIYRGPSHTYKVQRLTEFTCYSFRIQAASEAG-EGPFSETYTFSTTKSVPPTIKAPRVTQLEGNSCEILWETVPSmkGDP 1084
Cdd:COG3401    278 KVATVTTTSYTDTGLTNGTTYYYRVTAVDAAGnESAPSNVVSVTTDLTPPAAPSGLTATAVGSSSITLSWTASSD--ADV 355

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....
gi 2462592035 1085 VNYILQVLVGRESEYKQVYKGEEAT-FQISGLQTNTDYRFRVCA 1127
Cdd:COG3401    356 TGYNVYRSTSGGGTYTKIAETVTTTsYTDTGLTPGTTYYYKVTA 399
fn3 pfam00041
Fibronectin type III domain;
382-463 7.34e-11

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 59.35  E-value: 7.34e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462592035  382 PFPPKLAHRSKSSLTLQWKAPIDNGSKITNYLLEWDEGKRNSGFRQCF-FGSQKHCKLTKLCPAMGYTFRLAARNDIGTS 460
Cdd:pfam00041    3 PSNLTVTDVTSTSLTVSWTPPPDGNGPITGYEVEYRPKNSGEPWNEITvPGTTTSVTLTGLKPGTEYEVRVQAVNGGGEG 82


                   ...
gi 2462592035  461 GYS 463
Cdd:pfam00041   83 PPS 85
fn3 pfam00041
Fibronectin type III domain;
573-657 1.59e-10

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 58.58  E-value: 1.59e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462592035  573 GPPTRPLVKgPVTSHGFSVKWDPPKDnGGSEILKYLLEITDGNSEANQWEVAYSGSATEYTFTHLKPGTLYKLRACCIST 652
Cdd:pfam00041    1 SAPSNLTVT-DVTSTSLTVSWTPPPD-GNGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNG 78


                   ....*
gi 2462592035  653 GGHSQ 657
Cdd:pfam00041   79 GGEGP 83
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 767-856 1.69e-10

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 58.66  E-value: 1.69e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462592035  767 PGQCKAPCISCTPDGCVLVGWESPDSSGADISEYRLEWGEDEESLELIY---HGTDTRFEIRDLLPAAQYCCRLQAFNQA 843
Cdd:cd00063      1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSGDWKEVevtPGSETSYTLTGLKPGTEYEFRVRAVNGG 80

                           90
                   ....*....|...
gi 2462592035  844 GAGPYSELVLCQT 856
Cdd:cd00063     81 GESPPSESVTVTT 93
fn3 pfam00041
Fibronectin type III domain;
886-947 5.17e-10

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 57.04  E-value: 5.17e-10
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462592035  886 LVLNWEEPCNNGSEILAYTIDL-------GDTSITVGNTTMHVM-KDLLPETTYRIRIQAINEIGAGPFS 947
Cdd:pfam00041   16 LTVSWTPPPDGNGPITGYEVEYrpknsgePWNEITVPGTTTSVTlTGLKPGTEYEVRVQAVNGGGEGPPS 85
fn3 pfam00041
Fibronectin type III domain;
687-755 8.50e-10

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 56.65  E-value: 8.50e-10
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462592035  687 EVHLEWDVPASESGcEVSEYSVE---MTEPEDVASEVYHGPELECTVGNLLPGTVYRFRVRALNDGGYGPYS 755
Cdd:pfam00041   15 SLTVSWTPPPDGNG-PITGYEVEyrpKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGGEGPPS 85
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 671-752 1.25e-09

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 56.08  E-value: 1.25e-09
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462592035   671 PGQCRPPRVLGRPKHkEVHLEWDVPASE-SGCEVSEYSVEMTEPEDVASEVYHGP-ELECTVGNLLPGTVYRFRVRALND 748
Cdd:smart00060    1 PSPPSNLRVTDVTST-SVTLSWEPPPDDgITGYIVGYRVEYREEGSEWKEVNVTPsSTSYTLTGLKPGTEYEFRVRAVNG 79


                    ....
gi 2462592035   749 GGYG 752
Cdd:smart00060   80 AGEG 83
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 886-954 4.18e-09

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 54.81  E-value: 4.18e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2462592035  886 LVLNWEEPCNNGSEILAYTIDLGDTS--------ITVGNTTMHVMKDLLPETTYRIRIQAINEIGAGPFSQFIKAKT 954
Cdd:cd00063     17 VTLSWTPPEDDGGPITGYVVEYREKGsgdwkeveVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGESPPSESVTVTT 93
fn3 pfam00041
Fibronectin type III domain;
783-849 5.54e-09

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 54.34  E-value: 5.54e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462592035  783 VLVGWESPDSSGADISEYRLEW---GEDEESLELIYHGTDTRFEIRDLLPAAQYCCRLQAFNQAGAGPYS 849
Cdd:pfam00041   16 LTVSWTPPPDGNGPITGYEVEYrpkNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGGEGPPS 85
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
283-635 1.25e-08

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 59.25  E-value: 1.25e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462592035  283 QVSNIQARAVVLSWAPPvglscgPHSGLSfpySYEVALSDKGrDGKYKIIYSGEELECNLKDLRPATDYHVRVYAM-YNS 361
Cdd:COG3401    240 TATADTPGSVTLSWDPV------TESDAT---GYRVYRSNSG-DGPFTKVATVTTTSYTDTGLTNGTTYYYRVTAVdAAG 309

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462592035  362 VKGSCSEPVSFTTHSCAPECPFPPKLAHRSKSSLTLQWKAPIDNGskITNYLLEWDEGKrNSGFRQ-CFFGSQKHCKLTK 440
Cdd:COG3401    310 NESAPSNVVSVTTDLTPPAAPSGLTATAVGSSSITLSWTASSDAD--VTGYNVYRSTSG-GGTYTKiAETVTTTSYTDTG 386

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462592035  441 LCPAMGYTFRLAARNDIGTSGYSQEVVCYTLGNIPQMPSAPRLVRAGITWVTLQWSkpEGCSPEEVITYTLEIQEDENDN 520
Cdd:COG3401    387 LTPGTTYYYKVTAVDAAGNESAPSEEVSATTASAASGESLTASVDAVPLTDVAGAT--AAASAASNPGVSAAVLADGGDT 464

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462592035  521 LFHPKYTGEDLTcTVKNLKRSTQYKFRLTASNTEGKSCPSEVLVCTTSPDRPGPPTRPLVKGPVTShgfSVKWDPPKDNG 600
Cdd:COG3401    465 GNAVPFTTTSST-VTATTTDTTTANLSVTTGSLVGGSGASSVTNSVSVIGASAAAAVGGAPDGTPN---VTGASPVTVGA 540

                          330       340       350
                   ....*....|....*....|....*....|....*
gi 2462592035  601 GSEILKYLLEITDGNSEANQWEVAYSGSATEYTFT 635
Cdd:COG3401    541 STGDVLITDLVSLTTSASSSVSGAGLGSGNLYLIT 575
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 280-374 3.27e-08

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 52.11  E-value: 3.27e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462592035  280 EKPQVSNIQARAVVLSWAPPVGLScGPHSGlsfpysYEVALSDKGRDGKYKI-IYSGEELECNLKDLRPATDYHVRVYAM 358
Cdd:cd00063      5 TNLRVTDVTSTSVTLSWTPPEDDG-GPITG------YVVEYREKGSGDWKEVeVTPGSETSYTLTGLKPGTEYEFRVRAV 77

                           90
                   ....*....|....*.
gi 2462592035  359 YNSVKGSCSEPVSFTT 374
Cdd:cd00063     78 NGGGESPPSESVTVTT 93
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 379-460 5.01e-08

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 51.46  E-value: 5.01e-08
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462592035   379 PECPFPPKLAHRSKSSLTLQWKAPIDNG--SKITNYLLEWDEgKRNSGFRQCFFGSQKHCKLTKLCPAMGYTFRLAARND 456
Cdd:smart00060    1 PSPPSNLRVTDVTSTSVTLSWEPPPDDGitGYIVGYRVEYRE-EGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNG 79


                    ....
gi 2462592035   457 IGTS 460
Cdd:smart00060   80 AGEG 83
COG4733 COG4733
Phage-related protein, tail protein J [Mobilome: prophages, transposons];
590-786 7.15e-08

Phage-related protein, tail protein J [Mobilome: prophages, transposons];


Pssm-ID: 443767 [Multi-domain]  Cd Length: 978  Bit Score: 56.88  E-value: 7.15e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462592035  590 SVKWDPPKDNGGseilkYLLEITDGNSEanqWEVAYSGSATEYTFTHLKPGTlYKLRACCISTGGHSQCSESLPVRTLS- 668
Cdd:COG4733    555 TVSWDAPAGAVA-----YEVEWRRDDGN---WVSVPRTSGTSFEVPGIYAGD-YEVRVRAINALGVSSAWAASSETTVTg 625

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462592035  669 -IAPgqcrPPRVLG---RPKHKEVHLEWDVPAsesGCEVSEYSVEMTEPEDVAS---EVYHGPELECTVGNLLPGTVYRF 741
Cdd:COG4733    626 kTAP----PPAPTGltaTGGLGGITLSWSFPV---DADTLRTEIRYSTTGDWASatvAQALYPGNTYTLAGLKAGQTYYY 698

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*.
gi 2462592035  742 RVRALNDGG-YGPYSDVSEITTAAGPPGQCKAPCISCTPDGCVLVG 786
Cdd:COG4733    699 RARAVDRSGnVSAWWVSGQASADAAGILDAITGQILETELGQELDA 744
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 478-557 5.71e-07

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 48.38  E-value: 5.71e-07
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462592035   478 PSAPRLVRA---GITWVTLQWSKPEGCSPEE-VITYTLEIQEDENDNLFHPKyTGEDLTCTVKNLKRSTQYKFRLTASNT 553
Cdd:smart00060    1 PSPPSNLRVtdvTSTSVTLSWEPPPDDGITGyIVGYRVEYREEGSEWKEVNV-TPSSTSYTLTGLKPGTEYEFRVRAVNG 79


                    ....
gi 2462592035   554 EGKS 557
Cdd:smart00060   80 AGEG 83
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1054-1127 6.23e-07

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 48.65  E-value: 6.23e-07
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462592035 1054 PPTIKAPRVTQLEGNSCEILWETVPSMKGDPVNYILQVLVGRESEYKQVYK--GEEATFQISGLQTNTDYRFRVCA 1127
Cdd:cd00063      1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSGDWKEVEVtpGSETSYTLTGLKPGTEYEFRVRA 76
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 767-846 9.05e-07

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 47.99  E-value: 9.05e-07
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462592035   767 PGQCKAPCISCTPDGCVLVGWESPDSSGAD--ISEYRLEWGE-DEESLELIYHGTDTRFEIRDLLPAAQYCCRLQAFNQA 843
Cdd:smart00060    1 PSPPSNLRVTDVTSTSVTLSWEPPPDDGITgyIVGYRVEYREeGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGA 80


                    ...
gi 2462592035   844 GAG 846
Cdd:smart00060   81 GEG 83
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 280-357 1.01e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 47.61  E-value: 1.01e-06
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2462592035   280 EKPQVSNIQARAVVLSWAPPVglscgPHSGLSFPYSYEVALSDKGRDGKyKIIYSGEELECNLKDLRPATDYHVRVYA 357
Cdd:smart00060    5 SNLRVTDVTSTSVTLSWEPPP-----DDGITGYIVGYRVEYREEGSEWK-EVNVTPSSTSYTLTGLKPGTEYEFRVRA 76
fn3 pfam00041
Fibronectin type III domain;
478-560 1.70e-06

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 47.02  E-value: 1.70e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462592035  478 PSAPRLVRAGITWVTLQWSKPEGCSpEEVITYTLEIQE-DENDNLFHPKYTGEDLTCTVKNLKRSTQYKFRLTASNTEGK 556
Cdd:pfam00041    3 PSNLTVTDVTSTSLTVSWTPPPDGN-GPITGYEVEYRPkNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGGE 81


                   ....
gi 2462592035  557 SCPS 560
Cdd:pfam00041   82 GPPS 85
fn3 pfam00041
Fibronectin type III domain;
282-357 1.73e-06

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 47.02  E-value: 1.73e-06
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462592035  282 PQVSNIQARAVVLSWAPPVGLScGPHSGlsfpYSYEVALSDKGRDGKYKIIySGEELECNLKDLRPATDYHVRVYA 357
Cdd:pfam00041    6 LTVTDVTSTSLTVSWTPPPDGN-GPITG----YEVEYRPKNSGEPWNEITV-PGTTTSVTLTGLKPGTEYEVRVQA 75
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 970-1049 1.73e-06

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 47.49  E-value: 1.73e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462592035  970 GPQSLKLKWgdSNSKTHAAEDIVYTLQLEDRNK---RFISIYRGPSHTYKVQRLTEFTCYSFRIQAASEAGEGPFSETYT 1046
Cdd:cd00063     13 TSTSVTLSW--TPPEDDGGPITGYVVEYREKGSgdwKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGESPPSESVT 90


                   ...
gi 2462592035 1047 FST 1049
Cdd:cd00063     91 VTT 93
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
1014-1127 4.55e-06

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 50.77  E-value: 4.55e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462592035 1014 TYKVQRLTEFTCYSFRIQAASEAGEGPFSETYTFsTTKSVPPTikAP---RVTQLEGNSCEILWETVPSMkgDPVNYILQ 1090
Cdd:COG3401    193 VDGGGDIEPGTTYYYRVAATDTGGESAPSNEVSV-TTPTTPPS--APtglTATADTPGSVTLSWDPVTES--DATGYRVY 267

                           90       100       110
                   ....*....|....*....|....*....|....*..
gi 2462592035 1091 VLVGRESEYKQVYKGEEATFQISGLQTNTDYRFRVCA 1127
Cdd:COG3401    268 RSNSGDGPFTKVATVTTTSYTDTGLTNGTTYYYRVTA 304
fn3 pfam00041
Fibronectin type III domain;
1054-1127 5.94e-06

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 45.48  E-value: 5.94e-06
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462592035 1054 PPTIkaPRVTQLEGNSCEILWETVPSMKGDPVNYILQVLVGRESEYKQVY--KGEEATFQISGLQTNTDYRFRVCA 1127
Cdd:pfam00041    2 APSN--LTVTDVTSTSLTVSWTPPPDGNGPITGYEVEYRPKNSGEPWNEItvPGTTTSVTLTGLKPGTEYEVRVQA 75
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 861-944 6.59e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 45.30  E-value: 6.59e-06
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462592035   861 PDPVSTLCVLeeepldaypDSPSACLVLNWEEP--CNNGSEILAYTIDLGDTS------ITVGNTTMHVMKDLLPETTYR 932
Cdd:smart00060    1 PSPPSNLRVT---------DVTSTSVTLSWEPPpdDGITGYIVGYRVEYREEGsewkevNVTPSSTSYTLTGLKPGTEYE 71

                            90
                    ....*....|..
gi 2462592035   933 IRIQAINEIGAG 944
Cdd:smart00060   72 FRVRAVNGAGEG 83
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 968-1039 1.01e-04

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 42.22  E-value: 1.01e-04
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462592035   968 AAGPQSLKLKWGDSNSKTHAAEDIVYTLQLEDRNKRFISIYRGPSHT-YKVQRLTEFTCYSFRIQAASEAGEG 1039
Cdd:smart00060   11 DVTSTSVTLSWEPPPDDGITGYIVGYRVEYREEGSEWKEVNVTPSSTsYTLTGLKPGTEYEFRVRAVNGAGEG 83
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1054-1127 2.49e-04

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 41.06  E-value: 2.49e-04
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2462592035  1054 PPTIKAPRVTQLEGNSCEILWETVPSmkGDPVNYILQVLV---GRESEYKQVYKGEEAT-FQISGLQTNTDYRFRVCA 1127
Cdd:smart00060    1 PSPPSNLRVTDVTSTSVTLSWEPPPD--DGITGYIVGYRVeyrEEGSEWKEVNVTPSSTsYTLTGLKPGTEYEFRVRA 76
COG4733 COG4733
Phage-related protein, tail protein J [Mobilome: prophages, transposons];
491-654 1.16e-03

Phage-related protein, tail protein J [Mobilome: prophages, transposons];


Pssm-ID: 443767 [Multi-domain]  Cd Length: 978  Bit Score: 43.40  E-value: 1.16e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462592035  491 VTLQWSKPEGcspeeVITYTLEIQEDenDNLFHPKYTGEDLTCTVKNLKrSTQYKFRLTASNTEGKSCPSEVLVCTTSPD 570
Cdd:COG4733    554 LTVSWDAPAG-----AVAYEVEWRRD--DGNWVSVPRTSGTSFEVPGIY-AGDYEVRVRAINALGVSSAWAASSETTVTG 625

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462592035  571 RPGPPTRP----LVKGPvtsHGFSVKWDPPKDnggSEILKYLLEITDGNSEANQWEVAYSGSATEYTFTHLKPGTLYKLR 646
Cdd:COG4733    626 KTAPPPAPtgltATGGL---GGITLSWSFPVD---ADTLRTEIRYSTTGDWASATVAQALYPGNTYTLAGLKAGQTYYYR 699


                   ....*...
gi 2462592035  647 ACCISTGG 654
Cdd:COG4733    700 ARAVDRSG 707
fn3 pfam00041
Fibronectin type III domain;
973-1042 4.30e-03

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 37.39  E-value: 4.30e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462592035  973 SLKLKWgdSNSKTHAAEDIVYTLQLEDRNK------RFISiyrGPSHTYKVQRLTEFTCYSFRIQAASEAGEGPFS 1042
Cdd:pfam00041   15 SLTVSW--TPPPDGNGPITGYEVEYRPKNSgepwneITVP---GTTTSVTLTGLKPGTEYEVRVQAVNGGGEGPPS 85
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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