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Conserved domains on  [gi|2462593592|ref|XP_054204310|]
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U3 small nucleolar RNA-interacting protein 2 isoform X1 [Homo sapiens]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 10077586)

WD40 repeat domain-containing protein similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 95-395 2.25e-47

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


:

Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 164.05  E-value: 2.25e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462593592  95 IRVLRGHQLSITCLVVTPDDSAIFSAAKDCSIIKWSVESGRKLHVIprakkgaegkpPGHSSHVLCMAISSDGKYLASGD 174
Cdd:cd00200     2 RRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTL-----------KGHTGPVRDVAASADGTYLASGS 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462593592 175 RSKLILIWEAQSCQHLYTFTGHRDAVSGLAFRRGTHQLYSTSHDRSVKVWNVAENSYVETLFGHQDAVAALDALSRECCV 254
Cdd:cd00200    71 SDKTIRLWDLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFV 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462593592 255 TAGGRDGTVRVWKIPEES-QLVFYGHQGSIDCIHLI-NEEHMVSGADDGSVALWGLSKKRPLALqreahgLRGEPGleqp 332
Cdd:cd00200   151 ASSSQDGTIKLWDLRTGKcVATLTGHTGEVNSVAFSpDGEKLLSSSSDGTIKLWDLSTGKCLGT------LRGHEN---- 220

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2462593592 333 fWISSVAALLNTDLVATGSHSSCVRLWQcgegFRQLDLLCDIPLV-GFINSLKFSSSGDFLVAG 395
Cdd:cd00200   221 -GVNSVAFSPDGYLLASGSEDGTIRVWD----LRTGECVQTLSGHtNSVTSLAWSPDGKRLASG 279
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 95-395 2.25e-47

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 164.05  E-value: 2.25e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462593592  95 IRVLRGHQLSITCLVVTPDDSAIFSAAKDCSIIKWSVESGRKLHVIprakkgaegkpPGHSSHVLCMAISSDGKYLASGD 174
Cdd:cd00200     2 RRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTL-----------KGHTGPVRDVAASADGTYLASGS 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462593592 175 RSKLILIWEAQSCQHLYTFTGHRDAVSGLAFRRGTHQLYSTSHDRSVKVWNVAENSYVETLFGHQDAVAALDALSRECCV 254
Cdd:cd00200    71 SDKTIRLWDLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFV 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462593592 255 TAGGRDGTVRVWKIPEES-QLVFYGHQGSIDCIHLI-NEEHMVSGADDGSVALWGLSKKRPLALqreahgLRGEPGleqp 332
Cdd:cd00200   151 ASSSQDGTIKLWDLRTGKcVATLTGHTGEVNSVAFSpDGEKLLSSSSDGTIKLWDLSTGKCLGT------LRGHEN---- 220

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2462593592 333 fWISSVAALLNTDLVATGSHSSCVRLWQcgegFRQLDLLCDIPLV-GFINSLKFSSSGDFLVAG 395
Cdd:cd00200   221 -GVNSVAFSPDGYLLASGSEDGTIRVWD----LRTGECVQTLSGHtNSVTSLAWSPDGKRLASG 279
WD40 COG2319
WD40 repeat [General function prediction only];
88-395 3.44e-47

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 167.01  E-value: 3.44e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462593592  88 QAPASADIRVLRGHQLSITCLVVTPDDSAIFSAAKDCSIIKWSVESGRKLHVIPrakkgaegkppGHSSHVLCMAISSDG 167
Cdd:COG2319   106 DLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLT-----------GHSGAVTSVAFSPDG 174

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462593592 168 KYLASGDRSKLILIWEAQSCQHLYTFTGHRDAVSGLAFRRGTHQLYSTSHDRSVKVWNVAENSYVETLFGHQDAVAALdA 247
Cdd:COG2319   175 KLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSV-A 253

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462593592 248 LSREC-CVTAGGRDGTVRVWKIPEESQLVFY-GHQGSIDCIHLI-NEEHMVSGADDGSVALWGLSKKRPLalqreaHGLR 324
Cdd:COG2319   254 FSPDGrLLASGSADGTVRLWDLATGELLRTLtGHSGGVNSVAFSpDGKLLASGSDDGTVRLWDLATGKLL------RTLT 327

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2462593592 325 GEPGleqpfWISSVAALLNTDLVATGSHSSCVRLWQCGEGfrqldlLCDIPLVGF---INSLKFSSSGDFLVAG 395
Cdd:COG2319   328 GHTG-----AVRSVAFSPDGKTLASGSDDGTVRLWDLATG------ELLRTLTGHtgaVTSVAFSPDGRTLASG 390
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 154-360 1.30e-07

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 53.94  E-value: 1.30e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462593592 154 HSSHVLC-MAISSDGKYLASGDRSKLILIWEAQSC-------QHLYTFTGHRDAVSGLAFRRGTH-QLYSTSHDRSVKVW 224
Cdd:PLN00181  481 NSSNLVCaIGFDRDGEFFATAGVNKKIKIFECESIikdgrdiHYPVVELASRSKLSGICWNSYIKsQVASSNFEGVVQVW 560

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462593592 225 NVAENSYVETLFGHQDAVAALDALSRECCVTAGGR-DGTVRVWKI--------------------PEES----------Q 273
Cdd:PLN00181  561 DVARSQLVTEMKEHEKRVWSIDYSSADPTLLASGSdDGSVKLWSInqgvsigtiktkaniccvqfPSESgrslafgsadH 640

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462593592 274 LVFY--------------GHQGSIDCIHLINEEHMVSGADDGSVALWGLSKKRPLALQREAHGLRGEPGLEQPFWISsva 339
Cdd:PLN00181  641 KVYYydlrnpklplctmiGHSKTVSYVRFVDSSTLVSSSTDNTLKLWDLSMSISGINETPLHSFMGHTNVKNFVGLS--- 717

                         250       260
                  ....*....|....*....|.
gi 2462593592 340 alLNTDLVATGSHSSCVRLWQ 360
Cdd:PLN00181  718 --VSDGYIATGSETNEVFVYH 736
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 186-225 2.64e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.84  E-value: 2.64e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 2462593592  186 SCQHLYTFTGHRDAVSGLAFRRGTHQLYSTSHDRSVKVWN 225
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
188-225 7.96e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 42.72  E-value: 7.96e-06
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 2462593592 188 QHLYTFTGHRDAVSGLAFRRGTHQLYSTSHDRSVKVWN 225
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 95-395 2.25e-47

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 164.05  E-value: 2.25e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462593592  95 IRVLRGHQLSITCLVVTPDDSAIFSAAKDCSIIKWSVESGRKLHVIprakkgaegkpPGHSSHVLCMAISSDGKYLASGD 174
Cdd:cd00200     2 RRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTL-----------KGHTGPVRDVAASADGTYLASGS 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462593592 175 RSKLILIWEAQSCQHLYTFTGHRDAVSGLAFRRGTHQLYSTSHDRSVKVWNVAENSYVETLFGHQDAVAALDALSRECCV 254
Cdd:cd00200    71 SDKTIRLWDLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFV 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462593592 255 TAGGRDGTVRVWKIPEES-QLVFYGHQGSIDCIHLI-NEEHMVSGADDGSVALWGLSKKRPLALqreahgLRGEPGleqp 332
Cdd:cd00200   151 ASSSQDGTIKLWDLRTGKcVATLTGHTGEVNSVAFSpDGEKLLSSSSDGTIKLWDLSTGKCLGT------LRGHEN---- 220

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2462593592 333 fWISSVAALLNTDLVATGSHSSCVRLWQcgegFRQLDLLCDIPLV-GFINSLKFSSSGDFLVAG 395
Cdd:cd00200   221 -GVNSVAFSPDGYLLASGSEDGTIRVWD----LRTGECVQTLSGHtNSVTSLAWSPDGKRLASG 279
WD40 COG2319
WD40 repeat [General function prediction only];
88-395 3.44e-47

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 167.01  E-value: 3.44e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462593592  88 QAPASADIRVLRGHQLSITCLVVTPDDSAIFSAAKDCSIIKWSVESGRKLHVIPrakkgaegkppGHSSHVLCMAISSDG 167
Cdd:COG2319   106 DLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLT-----------GHSGAVTSVAFSPDG 174

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462593592 168 KYLASGDRSKLILIWEAQSCQHLYTFTGHRDAVSGLAFRRGTHQLYSTSHDRSVKVWNVAENSYVETLFGHQDAVAALdA 247
Cdd:COG2319   175 KLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSV-A 253

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462593592 248 LSREC-CVTAGGRDGTVRVWKIPEESQLVFY-GHQGSIDCIHLI-NEEHMVSGADDGSVALWGLSKKRPLalqreaHGLR 324
Cdd:COG2319   254 FSPDGrLLASGSADGTVRLWDLATGELLRTLtGHSGGVNSVAFSpDGKLLASGSDDGTVRLWDLATGKLL------RTLT 327

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2462593592 325 GEPGleqpfWISSVAALLNTDLVATGSHSSCVRLWQCGEGfrqldlLCDIPLVGF---INSLKFSSSGDFLVAG 395
Cdd:COG2319   328 GHTG-----AVRSVAFSPDGKTLASGSDDGTVRLWDLATG------ELLRTLTGHtgaVTSVAFSPDGRTLASG 390
WD40 COG2319
WD40 repeat [General function prediction only];
95-360 5.40e-46

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 163.54  E-value: 5.40e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462593592  95 IRVLRGHQLSITCLVVTPDDSAIFSAAKDCSIIKWSVESGRKLHVIPrakkgaegkppGHSSHVLCMAISSDGKYLASGD 174
Cdd:COG2319   155 LRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLT-----------GHTGAVRSVAFSPDGKLLASGS 223

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462593592 175 RSKLILIWEAQSCQHLYTFTGHRDAVSGLAFRRGTHQLYSTSHDRSVKVWNVAENSYVETLFGHQDAVAALdALSRE-CC 253
Cdd:COG2319   224 ADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSV-AFSPDgKL 302

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462593592 254 VTAGGRDGTVRVWKIPEESQL-VFYGHQGSIDCIHLI-NEEHMVSGADDGSVALWGLSKKRPLALqreahgLRGEPGleq 331
Cdd:COG2319   303 LASGSDDGTVRLWDLATGKLLrTLTGHTGAVRSVAFSpDGKTLASGSDDGTVRLWDLATGELLRT------LTGHTG--- 373

                         250       260
                  ....*....|....*....|....*....
gi 2462593592 332 pfWISSVAALLNTDLVATGSHSSCVRLWQ 360
Cdd:COG2319   374 --AVTSVAFSPDGRTLASGSADGTVRLWD 400
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 95-360 2.52e-45

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 158.65  E-value: 2.52e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462593592  95 IRVLRGHQLSITCLVVTPDDSAIFSAAKDCSIIKWSVESGRKLHVIPrakkgaegkppGHSSHVLCMAISSDGKYLASGD 174
Cdd:cd00200    44 LRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRTLT-----------GHTSYVSSVAFSPDGRILSSSS 112

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462593592 175 RSKLILIWEAQSCQHLYTFTGHRDAVSGLAFRRGTHQLYSTSHDRSVKVWNVAENSYVETLFGHQDAVAALDALSRECCV 254
Cdd:cd00200   113 RDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKL 192

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462593592 255 TAGGRDGTVRVWKIPEESQL-VFYGHQGSIDCIHLI-NEEHMVSGADDGSVALWGLSKKRPLALqreahgLRGEPGleqp 332
Cdd:cd00200   193 LSSSSDGTIKLWDLSTGKCLgTLRGHENGVNSVAFSpDGYLLASGSEDGTIRVWDLRTGECVQT------LSGHTN---- 262

                         250       260
                  ....*....|....*....|....*...
gi 2462593592 333 fWISSVAALLNTDLVATGSHSSCVRLWQ 360
Cdd:cd00200   263 -SVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
46-395 1.53e-42

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 154.30  E-value: 1.53e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462593592  46 LRQQEEEKAEARAFEEDQVAGRLKEDVLEQRGRLQKLVAKEIQAPASADIRVLRGHQLSITCLVVTPDDSAIFSAAKDCS 125
Cdd:COG2319    22 AAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGT 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462593592 126 IIKWSVESGRKLHViprakkgaegkPPGHSSHVLCMAISSDGKYLASGDRSKLILIWEAQSCQHLYTFTGHRDAVSGLAF 205
Cdd:COG2319   102 VRLWDLATGLLLRT-----------LTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAF 170

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462593592 206 RRGTHQLYSTSHDRSVKVWNVAENSYVETLFGHQDAVAALdALSRE-CCVTAGGRDGTVRVWKIPEESQL-VFYGHQGSI 283
Cdd:COG2319   171 SPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSV-AFSPDgKLLASGSADGTVRLWDLATGKLLrTLTGHSGSV 249

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462593592 284 DCIHL-INEEHMVSGADDGSVALWGLSKKRPLALqreahgLRGEPGleqpfWISSVAALLNTDLVATGSHSSCVRLWQCG 362
Cdd:COG2319   250 RSVAFsPDGRLLASGSADGTVRLWDLATGELLRT------LTGHSG-----GVNSVAFSPDGKLLASGSDDGTVRLWDLA 318

                         330       340       350
                  ....*....|....*....|....*....|...
gi 2462593592 363 EGfRQLDLLcdIPLVGFINSLKFSSSGDFLVAG 395
Cdd:COG2319   319 TG-KLLRTL--TGHTGAVRSVAFSPDGKTLASG 348
WD40 COG2319
WD40 repeat [General function prediction only];
95-309 5.96e-39

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 144.67  E-value: 5.96e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462593592  95 IRVLRGHQLSITCLVVTPDDSAIFSAAKDCSIIKWSVESGRKLHVIPrakkgaegkppGHSSHVLCMAISSDGKYLASGD 174
Cdd:COG2319   197 LRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLT-----------GHSGSVRSVAFSPDGRLLASGS 265

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462593592 175 RSKLILIWEAQSCQHLYTFTGHRDAVSGLAFRRGTHQLYSTSHDRSVKVWNVAENSYVETLFGHQDAVAALdALSRECCV 254
Cdd:COG2319   266 ADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSV-AFSPDGKT 344

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2462593592 255 TA-GGRDGTVRVWKIPEESQL-VFYGHQGSIDCIHLI-NEEHMVSGADDGSVALWGLS 309
Cdd:COG2319   345 LAsGSDDGTVRLWDLATGELLrTLTGHTGAVTSVAFSpDGRTLASGSADGTVRLWDLA 402
WD40 COG2319
WD40 repeat [General function prediction only];
71-412 1.74e-33

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 129.65  E-value: 1.74e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462593592  71 DVLEQRGRLQKLVAKEIQAPASADIRVLRGHQLSITCLVVTPDDSAIFSAAKDCSIIKWSVESGRKLHViprakkgaegk 150
Cdd:COG2319     5 DGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLAT----------- 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462593592 151 PPGHSSHVLCMAISSDGKYLASGDRSKLILIWEAQSCQHLYTFTGHRDAVSGLAFRRGTHQLYSTSHDRSVKVWNVAENS 230
Cdd:COG2319    74 LLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGK 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462593592 231 YVETLFGHQDAVAALdALS----ReccVTAGGRDGTVRVWKIPEESQL-VFYGHQGSIDCIHLI-NEEHMVSGADDGSVA 304
Cdd:COG2319   154 LLRTLTGHSGAVTSV-AFSpdgkL---LASGSDDGTVRLWDLATGKLLrTLTGHTGAVRSVAFSpDGKLLASGSADGTVR 229

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462593592 305 LWGLSKKRPLALqreahgLRGEPGleqpfWISSVAALLNTDLVATGSHSSCVRLWQCGEGfRQLDLLCDIPlvGFINSLK 384
Cdd:COG2319   230 LWDLATGKLLRT------LTGHSG-----SVRSVAFSPDGRLLASGSADGTVRLWDLATG-ELLRTLTGHS--GGVNSVA 295

                         330       340
                  ....*....|....*....|....*...
gi 2462593592 385 FSSSGDFLVAGvGQEHRLgRWWRIKEAR 412
Cdd:COG2319   296 FSPDGKLLASG-SDDGTV-RLWDLATGK 321
WD40 COG2319
WD40 repeat [General function prediction only];
162-395 2.83e-17

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 83.04  E-value: 2.83e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462593592 162 AISSDGKYLASGDRSKLILIWEAQSCQHLYTFTGHRDAVSGLAFRRGTHQLYSTSHDRSVKVWNVAENSYVETLFGHQDA 241
Cdd:COG2319     1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462593592 242 VAALDALSRECCVTAGGRDGTVRVWKIPEESQL-VFYGHQGSIDCIHL-INEEHMVSGADDGSVALWGLSKKRPLALqre 319
Cdd:COG2319    81 VLSVAFSPDGRLLASASADGTVRLWDLATGLLLrTLTGHTGAVRSVAFsPDGKTLASGSADGTVRLWDLATGKLLRT--- 157

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462593592 320 ahgLRGEPGleqpfWISSVAALLNTDLVATGSHSSCVRLWQCGEGfRQLDLLCDIPlvGFINSLKFSSSGDFLVAG 395
Cdd:COG2319   158 ---LTGHSG-----AVTSVAFSPDGKLLASGSDDGTVRLWDLATG-KLLRTLTGHT--GAVRSVAFSPDGKLLASG 222
WD40 COG2319
WD40 repeat [General function prediction only];
95-186 1.62e-11

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 65.70  E-value: 1.62e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462593592  95 IRVLRGHQLSITCLVVTPDDSAIFSAAKDCSIIKWSVESGRKLHVIPrakkgaegkppGHSSHVLCMAISSDGKYLASGD 174
Cdd:COG2319   323 LRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLT-----------GHTGAVTSVAFSPDGRTLASGS 391

                          90
                  ....*....|..
gi 2462593592 175 RSKLILIWEAQS 186
Cdd:COG2319   392 ADGTVRLWDLAT 403
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 154-360 1.30e-07

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 53.94  E-value: 1.30e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462593592 154 HSSHVLC-MAISSDGKYLASGDRSKLILIWEAQSC-------QHLYTFTGHRDAVSGLAFRRGTH-QLYSTSHDRSVKVW 224
Cdd:PLN00181  481 NSSNLVCaIGFDRDGEFFATAGVNKKIKIFECESIikdgrdiHYPVVELASRSKLSGICWNSYIKsQVASSNFEGVVQVW 560

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462593592 225 NVAENSYVETLFGHQDAVAALDALSRECCVTAGGR-DGTVRVWKI--------------------PEES----------Q 273
Cdd:PLN00181  561 DVARSQLVTEMKEHEKRVWSIDYSSADPTLLASGSdDGSVKLWSInqgvsigtiktkaniccvqfPSESgrslafgsadH 640

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462593592 274 LVFY--------------GHQGSIDCIHLINEEHMVSGADDGSVALWGLSKKRPLALQREAHGLRGEPGLEQPFWISsva 339
Cdd:PLN00181  641 KVYYydlrnpklplctmiGHSKTVSYVRFVDSSTLVSSSTDNTLKLWDLSMSISGINETPLHSFMGHTNVKNFVGLS--- 717

                         250       260
                  ....*....|....*....|.
gi 2462593592 340 alLNTDLVATGSHSSCVRLWQ 360
Cdd:PLN00181  718 --VSDGYIATGSETNEVFVYH 736
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 186-225 2.64e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.84  E-value: 2.64e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 2462593592  186 SCQHLYTFTGHRDAVSGLAFRRGTHQLYSTSHDRSVKVWN 225
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
188-225 7.96e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 42.72  E-value: 7.96e-06
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 2462593592 188 QHLYTFTGHRDAVSGLAFRRGTHQLYSTSHDRSVKVWN 225
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 152-183 2.75e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 41.14  E-value: 2.75e-05
                           10        20        30
                   ....*....|....*....|....*....|..
gi 2462593592  152 PGHSSHVLCMAISSDGKYLASGDRSKLILIWE 183
Cdd:smart00320   9 KGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
152-183 6.97e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 40.02  E-value: 6.97e-05
                          10        20        30
                  ....*....|....*....|....*....|..
gi 2462593592 152 PGHSSHVLCMAISSDGKYLASGDRSKLILIWE 183
Cdd:pfam00400   8 EGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 95-130 2.62e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.45  E-value: 2.62e-04
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 2462593592   95 IRVLRGHQLSITCLVVTPDDSAIFSAAKDCSIIKWS 130
Cdd:smart00320   5 LKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
95-130 4.21e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 37.71  E-value: 4.21e-04
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 2462593592  95 IRVLRGHQLSITCLVVTPDDSAIFSAAKDCSIIKWS 130
Cdd:pfam00400   4 LKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
232-266 8.73e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.94  E-value: 8.73e-04
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 2462593592 232 VETLFGHQDAVAALDALSRECCVTAGGRDGTVRVW 266
Cdd:pfam00400   4 LKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 230-267 3.42e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 34.98  E-value: 3.42e-03
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 2462593592  230 SYVETLFGHQDAVAALDALSRECCVTAGGRDGTVRVWK 267
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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