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Conserved domains on  [gi|2462594428|ref|XP_054204672|]
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tetraspanin-5 isoform X4 [Homo sapiens]

Protein Classification

tetraspanin family protein( domain architecture ID 11992924)

tetraspanin family protein is a transmembrane (TM) glycoprotein with four TM segments that facilitates the interaction of membrane and intracellular signaling molecules (such as integrins, pro-growth factors and their receptors, protein kinase-C) in the formation of membrane signaling microdomains (also referred to as the tetraspanin web)

Gene Ontology:  GO:0016020
PubMed:  15763890|11756464|19709882|16024509
SCOP:  4001512

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
tetraspanin_LEL super family cl02781
Tetraspanin, extracellular domain or large extracellular loop (LEL). Tetraspanins are ...
 64-101 1.24e-19

Tetraspanin, extracellular domain or large extracellular loop (LEL). Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. The tetraspanin family contains CD9, CD63, CD37, CD53, CD82, CD151, and CD81, amongst others. Tetraspanins are involved in diverse processes such as cell activation and proliferation, adhesion and motility, differentiation, cancer, and others. Their various functions may relate to their ability to act as molecular facilitators, grouping specific cell-surface proteins and affecting formation and stability of signaling complexes. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web", which may also include integrins.


The actual alignment was detected with superfamily member cd03159:

Pssm-ID: 351888 [Multi-domain]  Cd Length: 121  Bit Score: 78.62  E-value: 1.24e-19
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 2462594428  64 FVFKDWIKDQLYFFINNNIRAYRDDIDLQNLIDFTQEY 101
Cdd:cd03159     1 FVFKDWIKDQLTEFLNNNIRAYRDDIDLQNLIDFLQEY 38
Tetraspanin pfam00335
Tetraspanin family;
15-100 1.43e-08

Tetraspanin family;


:

Pssm-ID: 459767  Cd Length: 183  Bit Score: 50.78  E-value: 1.43e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462594428  15 IKYFIFGFNVIFWFLGITFLGIGLW----------------------------------------AWNEK------FSVF 48
Cdd:pfam00335   1 LKYLLFLFNLLFWLLGLLLLGVGVWllsafsllllglseasayipillivlgaviflvgflgccgALKENrcllltYFVL 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2462594428  49 LGIIFFLELTAGVLAFVFKDWIKDQLYFFINNNI-RAYRDDIDL----QNLIDFTQE 100
Cdd:pfam00335  81 LLLLFLAELAAGILAFVYRDKLSGLLSNWLKKSLeDGYRDWLDLysclNSALDSLQS 137
 
Name Accession Description Interval E-value
TM4SF9_like_LEL cd03159
Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF9_like subfamily. ...
 64-101 1.24e-19

Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF9_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". This subfamily contaions transmembrane 4 superfamily 9 (TM4SF9) or Tetraspanin-5 and related proteins. TM4SF9 is strongly expressed witin the central nervous system, and expression levels appear to correlate with differentiation status of particular neurons, hinting at a role in neuronal maturation.


Pssm-ID: 239412 [Multi-domain]  Cd Length: 121  Bit Score: 78.62  E-value: 1.24e-19
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 2462594428  64 FVFKDWIKDQLYFFINNNIRAYRDDIDLQNLIDFTQEY 101
Cdd:cd03159     1 FVFKDWIKDQLTEFLNNNIRAYRDDIDLQNLIDFLQEY 38
Tetraspanin pfam00335
Tetraspanin family;
15-100 1.43e-08

Tetraspanin family;


Pssm-ID: 459767  Cd Length: 183  Bit Score: 50.78  E-value: 1.43e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462594428  15 IKYFIFGFNVIFWFLGITFLGIGLW----------------------------------------AWNEK------FSVF 48
Cdd:pfam00335   1 LKYLLFLFNLLFWLLGLLLLGVGVWllsafsllllglseasayipillivlgaviflvgflgccgALKENrcllltYFVL 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2462594428  49 LGIIFFLELTAGVLAFVFKDWIKDQLYFFINNNI-RAYRDDIDL----QNLIDFTQE 100
Cdd:pfam00335  81 LLLLFLAELAAGILAFVYRDKLSGLLSNWLKKSLeDGYRDWLDLysclNSALDSLQS 137
 
Name Accession Description Interval E-value
TM4SF9_like_LEL cd03159
Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF9_like subfamily. ...
 64-101 1.24e-19

Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF9_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". This subfamily contaions transmembrane 4 superfamily 9 (TM4SF9) or Tetraspanin-5 and related proteins. TM4SF9 is strongly expressed witin the central nervous system, and expression levels appear to correlate with differentiation status of particular neurons, hinting at a role in neuronal maturation.


Pssm-ID: 239412 [Multi-domain]  Cd Length: 121  Bit Score: 78.62  E-value: 1.24e-19
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 2462594428  64 FVFKDWIKDQLYFFINNNIRAYRDDIDLQNLIDFTQEY 101
Cdd:cd03159     1 FVFKDWIKDQLTEFLNNNIRAYRDDIDLQNLIDFLQEY 38
Tetraspanin pfam00335
Tetraspanin family;
15-100 1.43e-08

Tetraspanin family;


Pssm-ID: 459767  Cd Length: 183  Bit Score: 50.78  E-value: 1.43e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462594428  15 IKYFIFGFNVIFWFLGITFLGIGLW----------------------------------------AWNEK------FSVF 48
Cdd:pfam00335   1 LKYLLFLFNLLFWLLGLLLLGVGVWllsafsllllglseasayipillivlgaviflvgflgccgALKENrcllltYFVL 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2462594428  49 LGIIFFLELTAGVLAFVFKDWIKDQLYFFINNNI-RAYRDDIDL----QNLIDFTQE 100
Cdd:pfam00335  81 LLLLFLAELAAGILAFVYRDKLSGLLSNWLKKSLeDGYRDWLDLysclNSALDSLQS 137
penumbra_like_LEL cd03158
Tetraspanin, extracellular domain or large extracellular loop (LEL), penumbra_like family. ...
 64-100 2.03e-07

Tetraspanin, extracellular domain or large extracellular loop (LEL), penumbra_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". Human Penumbra exhibits growth-suppressive activity in vitro and has been associated with myeloid malignancies.


Pssm-ID: 239411  Cd Length: 119  Bit Score: 46.53  E-value: 2.03e-07
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 2462594428  64 FVFKDWIKDQLYFFINNNIRAYRDDIDLQNLIDFTQE 100
Cdd:cd03158     1 FIFSNQTIDLLEENIRKAIVHYYDDLDLQNIIDFVQK 37
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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