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Conserved domains on  [gi|2462594753|ref|XP_054204832|]
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WD repeat-containing protein 17 isoform X5 [Homo sapiens]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
357-628 5.65e-49

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 179.72  E-value: 5.65e-49
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462594753  357 AFSLPPGHAVCCFLDGGVGLYDMGAKKWdFLRDLGHVETIFDCKFKPDDpNLLATASFDGTIKVWDINTLTAVYTSPGNE 436
Cdd:COG2319     85 AFSPDGRLLASASADGTVRLWDLATGLL-LRTLTGHTGAVRSVAFSPDG-KTLASGSADGTVRLWDLATGKLLRTLTGHS 162

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462594753  437 GVIYSLSWAPGGlNCIAGGTSRNGAFIWNVQKGKIIQRFNEHgTNGIFCIAWSHkDSKRIATCSSDGfcIIRTID---GK 513
Cdd:COG2319    163 GAVTSVAFSPDG-KLLASGSDDGTVRLWDLATGKLLRTLTGH-TGAVRSVAFSP-DGKLLASGSADG--TVRLWDlatGK 237

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462594753  514 VLHKYK-HPAAVFGCDWSQN---------NNTVRIWDYTQDACINILNGHTAPVRGLMWNteiP--YLLISGSWDYTIKV 581
Cdd:COG2319    238 LLRTLTgHSGSVRSVAFSPDgrllasgsaDGTVRLWDLATGELLRTLTGHSGGVNSVAFS---PdgKLLASGSDDGTVRL 314

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....*..
gi 2462594753  582 WDTREGTCVDTVYDHGADVYGLTCHPSRPfTMASCSRDSTVRLWSLT 628
Cdd:COG2319    315 WDLATGKLLRTLTGHTGAVRSVAFSPDGK-TLASGSDDGTVRLWDLA 360
WD40 COG2319
WD40 repeat [General function prediction only];
74-425 5.63e-16

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 81.50  E-value: 5.63e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462594753   74 KLHAIMSEHKKTITAISWcphNPD--LFASGSTDNLVIIWNVAEQKVIAKLDSTKGIPASLSWCWNAEdVVAFVSHRGPL 151
Cdd:COG2319    111 LLLRTLTGHTGAVRSVAF---SPDgkTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGK-LLASGSDDGTV 186

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462594753  152 FIW---------TISGPDSGVivhkdaHS--FLSDicmfrwhthqkGK-VVFGHIDGSLSIFHPGNKNQKHVLrpesleg 219
Cdd:COG2319    187 RLWdlatgkllrTLTGHTGAV------RSvaFSPD-----------GKlLASGSADGTVRLWDLATGKLLRTL------- 242

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462594753  220 TDEEDPVTALEWDPLSTdYLLVVNLHYGIRLVDSESLSCITTfnLPSAAASVQCLAWVPSApGMFITGdSQVGVLRIWNV 299
Cdd:COG2319    243 TGHSGSVRSVAFSPDGR-LLASGSADGTVRLWDLATGELLRT--LTGHSGGVNSVAFSPDG-KLLASG-SDDGTVRLWDL 317

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462594753  300 SrttpidnlklkkTGfHCLHVLNSPPRKKFSVqsptknhytsstseavppptltqnqAFSlPPG-HAVCCFLDGGVGLYD 378
Cdd:COG2319    318 A------------TG-KLLRTLTGHTGAVRSV-------------------------AFS-PDGkTLASGSDDGTVRLWD 358

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|....*...
gi 2462594753  379 MGAKKWdfLRDL-GHVETIFDCKFKPDDpNLLATASFDGTIKVWDINT 425
Cdd:COG2319    359 LATGEL--LRTLtGHTGAVTSVAFSPDG-RTLASGSADGTVRLWDLAT 403
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
357-628 5.65e-49

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 179.72  E-value: 5.65e-49
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462594753  357 AFSLPPGHAVCCFLDGGVGLYDMGAKKWdFLRDLGHVETIFDCKFKPDDpNLLATASFDGTIKVWDINTLTAVYTSPGNE 436
Cdd:COG2319     85 AFSPDGRLLASASADGTVRLWDLATGLL-LRTLTGHTGAVRSVAFSPDG-KTLASGSADGTVRLWDLATGKLLRTLTGHS 162

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462594753  437 GVIYSLSWAPGGlNCIAGGTSRNGAFIWNVQKGKIIQRFNEHgTNGIFCIAWSHkDSKRIATCSSDGfcIIRTID---GK 513
Cdd:COG2319    163 GAVTSVAFSPDG-KLLASGSDDGTVRLWDLATGKLLRTLTGH-TGAVRSVAFSP-DGKLLASGSADG--TVRLWDlatGK 237

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462594753  514 VLHKYK-HPAAVFGCDWSQN---------NNTVRIWDYTQDACINILNGHTAPVRGLMWNteiP--YLLISGSWDYTIKV 581
Cdd:COG2319    238 LLRTLTgHSGSVRSVAFSPDgrllasgsaDGTVRLWDLATGELLRTLTGHSGGVNSVAFS---PdgKLLASGSDDGTVRL 314

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....*..
gi 2462594753  582 WDTREGTCVDTVYDHGADVYGLTCHPSRPfTMASCSRDSTVRLWSLT 628
Cdd:COG2319    315 WDLATGKLLRTLTGHTGAVRSVAFSPDGK-TLASGSDDGTVRLWDLA 360
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 363-626 3.42e-44

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 162.12  E-value: 3.42e-44
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462594753  363 GHA----VCCFLDGG----VGLYDMGAKKWDF------LRDLGHVETIFDCKFKPDDpNLLATASFDGTIKVWDINTLTA 428
Cdd:cd00200      7 GHTggvtCVAFSPDGkllaTGSGDGTIKVWDLetgellRTLKGHTGPVRDVAASADG-TYLASGSSDKTIRLWDLETGEC 85

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462594753  429 VYTSPGNEGVIYSLSWAPGGlNCIAGGTSRNGAFIWNVQKGKIIQRFNEHgTNGIFCIAWSHkDSKRIATCSSDGFciIR 508
Cdd:cd00200     86 VRTLTGHTSYVSSVAFSPDG-RILSSSSRDKTIKVWDVETGKCLTTLRGH-TDWVNSVAFSP-DGTFVASSSQDGT--IK 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462594753  509 TID---GKVLHKYK-HPAAVFGCDWSQNN---------NTVRIWDYTQDACINILNGHTAPVRGLMWNTEiPYLLISGSW 575
Cdd:cd00200    161 LWDlrtGKCVATLTgHTGEVNSVAFSPDGekllssssdGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPD-GYLLASGSE 239

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|.
gi 2462594753  576 DYTIKVWDTREGTCVDTVYDHGADVYGLTCHPSRPfTMASCSRDSTVRLWS 626
Cdd:cd00200    240 DGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGK-RLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
74-425 5.63e-16

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 81.50  E-value: 5.63e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462594753   74 KLHAIMSEHKKTITAISWcphNPD--LFASGSTDNLVIIWNVAEQKVIAKLDSTKGIPASLSWCWNAEdVVAFVSHRGPL 151
Cdd:COG2319    111 LLLRTLTGHTGAVRSVAF---SPDgkTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGK-LLASGSDDGTV 186

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462594753  152 FIW---------TISGPDSGVivhkdaHS--FLSDicmfrwhthqkGK-VVFGHIDGSLSIFHPGNKNQKHVLrpesleg 219
Cdd:COG2319    187 RLWdlatgkllrTLTGHTGAV------RSvaFSPD-----------GKlLASGSADGTVRLWDLATGKLLRTL------- 242

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462594753  220 TDEEDPVTALEWDPLSTdYLLVVNLHYGIRLVDSESLSCITTfnLPSAAASVQCLAWVPSApGMFITGdSQVGVLRIWNV 299
Cdd:COG2319    243 TGHSGSVRSVAFSPDGR-LLASGSADGTVRLWDLATGELLRT--LTGHSGGVNSVAFSPDG-KLLASG-SDDGTVRLWDL 317

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462594753  300 SrttpidnlklkkTGfHCLHVLNSPPRKKFSVqsptknhytsstseavppptltqnqAFSlPPG-HAVCCFLDGGVGLYD 378
Cdd:COG2319    318 A------------TG-KLLRTLTGHTGAVRSV-------------------------AFS-PDGkTLASGSDDGTVRLWD 358

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|....*...
gi 2462594753  379 MGAKKWdfLRDL-GHVETIFDCKFKPDDpNLLATASFDGTIKVWDINT 425
Cdd:COG2319    359 LATGEL--LRTLtGHTGAVTSVAFSPDG-RTLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 38-298 1.83e-09

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 60.43  E-value: 1.83e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462594753   38 CQPWNKDVCAASGDRfaycaTLAIYIYQLDHRYNEFKlhaimsEHKKTITAISWCPHNPdLFASGSTDNLVIIWNVAEQK 117
Cdd:cd00200     59 ASADGTYLASGSSDK-----TIRLWDLETGECVRTLT------GHTSYVSSVAFSPDGR-ILSSSSRDKTIKVWDVETGK 126

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462594753  118 VIAKLDSTKGIPASLSWCWNaEDVVAFVSHRGPLFIWTISgpdSGVIVHK-DAHSflSDICMFRWHtHQKGKVVFGHIDG 196
Cdd:cd00200    127 CLTTLRGHTDWVNSVAFSPD-GTFVASSSQDGTIKLWDLR---TGKCVATlTGHT--GEVNSVAFS-PDGEKLLSSSSDG 199

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462594753  197 SLSIFHPGNKNQKHVLRPEslegtdeEDPVTALEWDPlsTDYLLVVNLHYG-IRLVDSESLSCITTfnLPSAAASVQCLA 275
Cdd:cd00200    200 TIKLWDLSTGKCLGTLRGH-------ENGVNSVAFSP--DGYLLASGSEDGtIRVWDLRTGECVQT--LSGHTNSVTSLA 268

                          250       260
                   ....*....|....*....|...
gi 2462594753  276 WVPSAPgMFITGdSQVGVLRIWN 298
Cdd:cd00200    269 WSPDGK-RLASG-SADGTIRIWD 289
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 546-583 4.20e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 44.61  E-value: 4.20e-06
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 2462594753   546 CINILNGHTAPVRGLMWNTEIPYLlISGSWDYTIKVWD 583
Cdd:smart00320    4 LLKTLKGHTGPVTSVAFSPDGKYL-ASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
546-583 3.21e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.95  E-value: 3.21e-05
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 2462594753  546 CINILNGHTAPVRGLMWNTEIPYLlISGSWDYTIKVWD 583
Cdd:pfam00400    3 LLKTLEGHTGSVTSLAFSPDGKLL-ASGSDDGTVKVWD 39
PTZ00420 PTZ00420
coronin; Provisional
 550-650 3.77e-05

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 48.02  E-value: 3.77e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462594753  550 LNGHTAPVRGLMWNTEIPYLLISGSWDYTIKVWDTR-EGTCVDTVYD-------HGADVYGLTCHPSRPFTMASCSRDST 621
Cdd:PTZ00420    70 LKGHTSSILDLQFNPCFSEILASGSEDLTIRVWEIPhNDESVKEIKDpqcilkgHKKKISIIDWNPMNYYIMCSSGFDSF 149

                           90       100       110
                   ....*....|....*....|....*....|..
gi 2462594753  622 VRLWSLTALVTPVQINI---LADRSWeEIIGN 650
Cdd:PTZ00420   150 VNIWDIENEKRAFQINMpkkLSSLKW-NIKGN 180
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 73-112 4.22e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 41.91  E-value: 4.22e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 2462594753    73 FKLHAIMSEHKKTITAISWCPHNpDLFASGSTDNLVIIWN 112
Cdd:smart00320    2 GELLKTLKGHTGPVTSVAFSPDG-KYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
73-112 1.14e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 37.71  E-value: 1.14e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 2462594753   73 FKLHAIMSEHKKTITAISWCPHNpDLFASGSTDNLVIIWN 112
Cdd:pfam00400    1 GKLLKTLEGHTGSVTSLAFSPDG-KLLASGSDDGTVKVWD 39
PTZ00420 PTZ00420
coronin; Provisional
 59-134 2.50e-03

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 41.86  E-value: 2.50e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462594753   59 LAIYIYQLDHR---YNEFK-LHAIMSEHKKTITAISWCPHNPDLFASGSTDNLVIIWNVAEQKVIAKLDSTKGIpASLSW 134
Cdd:PTZ00420    97 LTIRVWEIPHNdesVKEIKdPQCILKGHKKKISIIDWNPMNYYIMCSSGFDSFVNIWDIENEKRAFQINMPKKL-SSLKW 175
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
357-628 5.65e-49

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 179.72  E-value: 5.65e-49
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462594753  357 AFSLPPGHAVCCFLDGGVGLYDMGAKKWdFLRDLGHVETIFDCKFKPDDpNLLATASFDGTIKVWDINTLTAVYTSPGNE 436
Cdd:COG2319     85 AFSPDGRLLASASADGTVRLWDLATGLL-LRTLTGHTGAVRSVAFSPDG-KTLASGSADGTVRLWDLATGKLLRTLTGHS 162

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462594753  437 GVIYSLSWAPGGlNCIAGGTSRNGAFIWNVQKGKIIQRFNEHgTNGIFCIAWSHkDSKRIATCSSDGfcIIRTID---GK 513
Cdd:COG2319    163 GAVTSVAFSPDG-KLLASGSDDGTVRLWDLATGKLLRTLTGH-TGAVRSVAFSP-DGKLLASGSADG--TVRLWDlatGK 237

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462594753  514 VLHKYK-HPAAVFGCDWSQN---------NNTVRIWDYTQDACINILNGHTAPVRGLMWNteiP--YLLISGSWDYTIKV 581
Cdd:COG2319    238 LLRTLTgHSGSVRSVAFSPDgrllasgsaDGTVRLWDLATGELLRTLTGHSGGVNSVAFS---PdgKLLASGSDDGTVRL 314

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....*..
gi 2462594753  582 WDTREGTCVDTVYDHGADVYGLTCHPSRPfTMASCSRDSTVRLWSLT 628
Cdd:COG2319    315 WDLATGKLLRTLTGHTGAVRSVAFSPDGK-TLASGSDDGTVRLWDLA 360
WD40 COG2319
WD40 repeat [General function prediction only];
371-628 1.12e-46

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 173.17  E-value: 1.12e-46
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462594753  371 DGGVGLYDMGAKKwdFLRDL-GHVETIFDCKFKPDDpNLLATASFDGTIKVWDINTLTAVYTSPGNEGVIYSLSWAPGGl 449
Cdd:COG2319    141 DGTVRLWDLATGK--LLRTLtGHSGAVTSVAFSPDG-KLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDG- 216

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462594753  450 NCIAGGTSRNGAFIWNVQKGKIIQRFNEHgTNGIFCIAWSHkDSKRIATCSSDG-FCIIRTIDGKVLHKYK-HPAAVFGC 527
Cdd:COG2319    217 KLLASGSADGTVRLWDLATGKLLRTLTGH-SGSVRSVAFSP-DGRLLASGSADGtVRLWDLATGELLRTLTgHSGGVNSV 294

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462594753  528 DWSQN---------NNTVRIWDYTQDACINILNGHTAPVRGLMWNteiPY--LLISGSWDYTIKVWDTREGTCVDTVYDH 596
Cdd:COG2319    295 AFSPDgkllasgsdDGTVRLWDLATGKLLRTLTGHTGAVRSVAFS---PDgkTLASGSDDGTVRLWDLATGELLRTLTGH 371

                          250       260       270
                   ....*....|....*....|....*....|..
gi 2462594753  597 GADVYGLTCHPSRPfTMASCSRDSTVRLWSLT 628
Cdd:COG2319    372 TGAVTSVAFSPDGR-TLASGSADGTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 363-626 3.42e-44

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 162.12  E-value: 3.42e-44
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462594753  363 GHA----VCCFLDGG----VGLYDMGAKKWDF------LRDLGHVETIFDCKFKPDDpNLLATASFDGTIKVWDINTLTA 428
Cdd:cd00200      7 GHTggvtCVAFSPDGkllaTGSGDGTIKVWDLetgellRTLKGHTGPVRDVAASADG-TYLASGSSDKTIRLWDLETGEC 85

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462594753  429 VYTSPGNEGVIYSLSWAPGGlNCIAGGTSRNGAFIWNVQKGKIIQRFNEHgTNGIFCIAWSHkDSKRIATCSSDGFciIR 508
Cdd:cd00200     86 VRTLTGHTSYVSSVAFSPDG-RILSSSSRDKTIKVWDVETGKCLTTLRGH-TDWVNSVAFSP-DGTFVASSSQDGT--IK 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462594753  509 TID---GKVLHKYK-HPAAVFGCDWSQNN---------NTVRIWDYTQDACINILNGHTAPVRGLMWNTEiPYLLISGSW 575
Cdd:cd00200    161 LWDlrtGKCVATLTgHTGEVNSVAFSPDGekllssssdGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPD-GYLLASGSE 239

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|.
gi 2462594753  576 DYTIKVWDTREGTCVDTVYDHGADVYGLTCHPSRPfTMASCSRDSTVRLWS 626
Cdd:cd00200    240 DGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGK-RLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 391-627 7.81e-40

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 149.79  E-value: 7.81e-40
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462594753  391 GHVETIFDCKFKPDdPNLLATASFDGTIKVWDINTLTAVYTSPGNEGVIYSLSWAPGGlNCIAGGTSRNGAFIWNVQKGK 470
Cdd:cd00200      7 GHTGGVTCVAFSPD-GKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADG-TYLASGSSDKTIRLWDLETGE 84

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462594753  471 IIQRFNEHgTNGIFCIAWSHkDSKRIATCSSDGFCII-RTIDGKVLHKYK-HPAAVFGCDWSQNN---------NTVRIW 539
Cdd:cd00200     85 CVRTLTGH-TSYVSSVAFSP-DGRILSSSSRDKTIKVwDVETGKCLTTLRgHTDWVNSVAFSPDGtfvasssqdGTIKLW 162

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462594753  540 DYTQDACINILNGHTAPVRGLMWnTEIPYLLISGSWDYTIKVWDTREGTCVDTVYDHGADVYGLTCHPSRPFtMASCSRD 619
Cdd:cd00200    163 DLRTGKCVATLTGHTGEVNSVAF-SPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYL-LASGSED 240


                   ....*...
gi 2462594753  620 STVRLWSL 627
Cdd:cd00200    241 GTIRVWDL 248
WD40 COG2319
WD40 repeat [General function prediction only];
387-628 7.01e-33

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 132.73  E-value: 7.01e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462594753  387 LRDLGHVETIFDCKFKPDDpNLLATASFDGTIKVWDINTLTAVYTSPGNEGVIYSLSWAPGGlNCIAGGTSRNGAFIWNV 466
Cdd:COG2319     30 LLLLGLAAAVASLAASPDG-ARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDG-RLLASASADGTVRLWDL 107

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462594753  467 QKGKIIQRFNEHgTNGIFCIAWSHkDSKRIATCSSDGF-CIIRTIDGKVLHKYK-HPAAVFGCDWSQN---------NNT 535
Cdd:COG2319    108 ATGLLLRTLTGH-TGAVRSVAFSP-DGKTLASGSADGTvRLWDLATGKLLRTLTgHSGAVTSVAFSPDgkllasgsdDGT 185

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462594753  536 VRIWDYTQDACINILNGHTAPVRGLMWNteiP--YLLISGSWDYTIKVWDTREGTCVDTVYDHGADVYGLTCHPSRPfTM 613
Cdd:COG2319    186 VRLWDLATGKLLRTLTGHTGAVRSVAFS---PdgKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGR-LL 261

                          250
                   ....*....|....*
gi 2462594753  614 ASCSRDSTVRLWSLT 628
Cdd:COG2319    262 ASGSADGTVRLWDLA 276
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 223-583 4.51e-32

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 127.07  E-value: 4.51e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462594753  223 EDPVTALEWDPLStDYLLVvnlhyG-----IRLVDSESLSCITTfnLPSAAASVQCLAWVPSAPGMFITG-DSQVgvlRI 296
Cdd:cd00200      9 TGGVTCVAFSPDG-KLLAT-----GsgdgtIKVWDLETGELLRT--LKGHTGPVRDVAASADGTYLASGSsDKTI---RL 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462594753  297 WNVSRTTPIDNLklkkTGfHCLHVlnspprkkFSVQSPTKNHYtsstseavppptltqnqafslppghAVCCFLDGGVGL 376
Cdd:cd00200     78 WDLETGECVRTL----TG-HTSYV--------SSVAFSPDGRI-------------------------LSSSSRDKTIKV 119

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462594753  377 YDMGAKKwdFLRDL-GHVETIFDCKFKPDDpNLLATASFDGTIKVWDINTLTAVYTSPGNEGVIYSLSWAPGGLNCIAGG 455
Cdd:cd00200    120 WDVETGK--CLTTLrGHTDWVNSVAFSPDG-TFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSS 196

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462594753  456 TSRNgAFIWNVQKGKIIQRFNEHgTNGIFCIAWSHkDSKRIATCSSDGfciirtidgkvlhkykhpaavfgcdwsqnnnT 535
Cdd:cd00200    197 SDGT-IKLWDLSTGKCLGTLRGH-ENGVNSVAFSP-DGYLLASGSEDG-------------------------------T 242

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|....*...
gi 2462594753  536 VRIWDYTQDACINILNGHTAPVRGLMWNTEIPYlLISGSWDYTIKVWD 583
Cdd:cd00200    243 IRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKR-LASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 472-630 3.48e-30

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 121.67  E-value: 3.48e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462594753  472 IQRFNEHgTNGIFCIAWsHKDSKRIATCSSDGFCII-RTIDGKVLHKYK-HPAAVFGCDWSQN---------NNTVRIWD 540
Cdd:cd00200      2 RRTLKGH-TGGVTCVAF-SPDGKLLATGSGDGTIKVwDLETGELLRTLKgHTGPVRDVAASADgtylasgssDKTIRLWD 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462594753  541 YTQDACINILNGHTAPVRGLMWNTEIPYLLiSGSWDYTIKVWDTREGTCVDTVYDHGADVYGLTCHPSRPFTmASCSRDS 620
Cdd:cd00200     80 LETGECVRTLTGHTSYVSSVAFSPDGRILS-SSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFV-ASSSQDG 157

                          170
                   ....*....|
gi 2462594753  621 TVRLWSLTAL 630
Cdd:cd00200    158 TIKLWDLRTG 167
WD40 COG2319
WD40 repeat [General function prediction only];
74-585 5.57e-18

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 87.66  E-value: 5.57e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462594753   74 KLHAIMSEHKKTITAISWcphNPD--LFASGSTDNLVIIWNVAEQKVIAKLDstkgipaslswcwnaedvvafvshrgpl 151
Cdd:COG2319    153 KLLRTLTGHSGAVTSVAF---SPDgkLLASGSDDGTVRLWDLATGKLLRTLT---------------------------- 201

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462594753  152 fiwtisgpdsgvivhkdahsflsdicmfrwhthqkgkvvfGHidgslsifhpgnknqkhvlrpeslegtdeEDPVTALEW 231
Cdd:COG2319    202 ----------------------------------------GH-----------------------------TGAVRSVAF 212

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462594753  232 DPlstdyllvvnlhygirlvDSESLscittfnlpsAAASvqclawvpsapgmfitGDsqvGVLRIWNVSRTTPIDNLKlk 311
Cdd:COG2319    213 SP------------------DGKLL----------ASGS----------------AD---GTVRLWDLATGKLLRTLT-- 243

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462594753  312 ktgfhclhvlnspprkkfsvqsptknhytsstseavppptltqnqafslppghavccfldggvglydmgakkwdflrdlG 391
Cdd:COG2319    244 -------------------------------------------------------------------------------G 244

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462594753  392 HVETIFDCKFKPDDpNLLATASFDGTIKVWDINTLTAVYTSPGNEGVIYSLSWAPGGlNCIAGGTSRNGAFIWNVQKGKI 471
Cdd:COG2319    245 HSGSVRSVAFSPDG-RLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDG-KLLASGSDDGTVRLWDLATGKL 322

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462594753  472 IQRFNEHgTNGIFCIAWSHkDSKRIATCSSDGfciirtidgkvlhkykhpaavfgcdwsqnnnTVRIWDYTQDACINILN 551
Cdd:COG2319    323 LRTLTGH-TGAVRSVAFSP-DGKTLASGSDDG-------------------------------TVRLWDLATGELLRTLT 369

                          490       500       510
                   ....*....|....*....|....*....|....
gi 2462594753  552 GHTAPVRGLMWNTEIPYlLISGSWDYTIKVWDTR 585
Cdd:COG2319    370 GHTGAVTSVAFSPDGRT-LASGSADGTVRLWDLA 402
WD40 COG2319
WD40 repeat [General function prediction only];
74-425 5.63e-16

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 81.50  E-value: 5.63e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462594753   74 KLHAIMSEHKKTITAISWcphNPD--LFASGSTDNLVIIWNVAEQKVIAKLDSTKGIPASLSWCWNAEdVVAFVSHRGPL 151
Cdd:COG2319    111 LLLRTLTGHTGAVRSVAF---SPDgkTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGK-LLASGSDDGTV 186

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462594753  152 FIW---------TISGPDSGVivhkdaHS--FLSDicmfrwhthqkGK-VVFGHIDGSLSIFHPGNKNQKHVLrpesleg 219
Cdd:COG2319    187 RLWdlatgkllrTLTGHTGAV------RSvaFSPD-----------GKlLASGSADGTVRLWDLATGKLLRTL------- 242

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462594753  220 TDEEDPVTALEWDPLSTdYLLVVNLHYGIRLVDSESLSCITTfnLPSAAASVQCLAWVPSApGMFITGdSQVGVLRIWNV 299
Cdd:COG2319    243 TGHSGSVRSVAFSPDGR-LLASGSADGTVRLWDLATGELLRT--LTGHSGGVNSVAFSPDG-KLLASG-SDDGTVRLWDL 317

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462594753  300 SrttpidnlklkkTGfHCLHVLNSPPRKKFSVqsptknhytsstseavppptltqnqAFSlPPG-HAVCCFLDGGVGLYD 378
Cdd:COG2319    318 A------------TG-KLLRTLTGHTGAVRSV-------------------------AFS-PDGkTLASGSDDGTVRLWD 358

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|....*...
gi 2462594753  379 MGAKKWdfLRDL-GHVETIFDCKFKPDDpNLLATASFDGTIKVWDINT 425
Cdd:COG2319    359 LATGEL--LRTLtGHTGAVTSVAFSPDG-RTLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 546-627 4.01e-12

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 68.52  E-value: 4.01e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462594753  546 CINILNGHTAPVRGLMWNTEIPYLLiSGSWDYTIKVWDTREGTCVDTVYDHGADVYGLTCHPSRPFtMASCSRDSTVRLW 625
Cdd:cd00200      1 LRRTLKGHTGGVTCVAFSPDGKLLA-TGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTY-LASGSSDKTIRLW 78


                   ..
gi 2462594753  626 SL 627
Cdd:cd00200     79 DL 80
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 38-298 1.83e-09

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 60.43  E-value: 1.83e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462594753   38 CQPWNKDVCAASGDRfaycaTLAIYIYQLDHRYNEFKlhaimsEHKKTITAISWCPHNPdLFASGSTDNLVIIWNVAEQK 117
Cdd:cd00200     59 ASADGTYLASGSSDK-----TIRLWDLETGECVRTLT------GHTSYVSSVAFSPDGR-ILSSSSRDKTIKVWDVETGK 126

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462594753  118 VIAKLDSTKGIPASLSWCWNaEDVVAFVSHRGPLFIWTISgpdSGVIVHK-DAHSflSDICMFRWHtHQKGKVVFGHIDG 196
Cdd:cd00200    127 CLTTLRGHTDWVNSVAFSPD-GTFVASSSQDGTIKLWDLR---TGKCVATlTGHT--GEVNSVAFS-PDGEKLLSSSSDG 199

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462594753  197 SLSIFHPGNKNQKHVLRPEslegtdeEDPVTALEWDPlsTDYLLVVNLHYG-IRLVDSESLSCITTfnLPSAAASVQCLA 275
Cdd:cd00200    200 TIKLWDLSTGKCLGTLRGH-------ENGVNSVAFSP--DGYLLASGSEDGtIRVWDLRTGECVQT--LSGHTNSVTSLA 268

                          250       260
                   ....*....|....*....|...
gi 2462594753  276 WVPSAPgMFITGdSQVGVLRIWN 298
Cdd:cd00200    269 WSPDGK-RLASG-SADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 75-326 6.79e-09

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 58.50  E-value: 6.79e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462594753   75 LHAIMSEHKKTITAISWCPHNpDLFASGSTDNLVIIWNVAEQKVIAKLDSTKGIPASLSWC-----------------WN 137
Cdd:cd00200      1 LRRTLKGHTGGVTCVAFSPDG-KLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASadgtylasgssdktirlWD 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462594753  138 AED---VVAFVSHRGPLFIWTISgPDSGVIVhkdAHSFLSDICMFRWHTHQKGKVVFGHIDGSLSI-FHPGNK------N 207
Cdd:cd00200     80 LETgecVRTLTGHTSYVSSVAFS-PDGRILS---SSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVaFSPDGTfvasssQ 155

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462594753  208 QKHV----LRPESLEGT--DEEDPVTALEWDPLSTDyLLVVNLHYGIRLVDSESLSCITTfnLPSAAASVQCLAWVPSap 281
Cdd:cd00200    156 DGTIklwdLRTGKCVATltGHTGEVNSVAFSPDGEK-LLSSSSDGTIKLWDLSTGKCLGT--LRGHENGVNSVAFSPD-- 230

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....*
gi 2462594753  282 GMFITGDSQVGVLRIWNVSRTTPIDNLKLKKTGFHCLHVLNSPPR 326
Cdd:cd00200    231 GYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKR 275
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 546-583 4.20e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 44.61  E-value: 4.20e-06
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 2462594753   546 CINILNGHTAPVRGLMWNTEIPYLlISGSWDYTIKVWD 583
Cdd:smart00320    4 LLKTLKGHTGPVTSVAFSPDGKYL-ASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
546-583 3.21e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.95  E-value: 3.21e-05
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 2462594753  546 CINILNGHTAPVRGLMWNTEIPYLlISGSWDYTIKVWD 583
Cdd:pfam00400    3 LLKTLEGHTGSVTSLAFSPDGKLL-ASGSDDGTVKVWD 39
PTZ00420 PTZ00420
coronin; Provisional
 550-650 3.77e-05

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 48.02  E-value: 3.77e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462594753  550 LNGHTAPVRGLMWNTEIPYLLISGSWDYTIKVWDTR-EGTCVDTVYD-------HGADVYGLTCHPSRPFTMASCSRDST 621
Cdd:PTZ00420    70 LKGHTSSILDLQFNPCFSEILASGSEDLTIRVWEIPhNDESVKEIKDpqcilkgHKKKISIIDWNPMNYYIMCSSGFDSF 149

                           90       100       110
                   ....*....|....*....|....*....|..
gi 2462594753  622 VRLWSLTALVTPVQINI---LADRSWeEIIGN 650
Cdd:PTZ00420   150 VNIWDIENEKRAFQINMpkkLSSLKW-NIKGN 180
PTZ00421 PTZ00421
coronin; Provisional
 390-511 3.99e-05

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 47.58  E-value: 3.99e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462594753  390 LGHVETIFDCKFKPDDPNLLATASFDGTIKVWDINT--LTAVYTSP-----GNEGVIYSLSWAPGGLNCIAGGTSRNGAF 462
Cdd:PTZ00421    72 LGQEGPIIDVAFNPFDPQKLFTASEDGTIMGWGIPEegLTQNISDPivhlqGHTKKVGIVSFHPSAMNVLASAGADMVVN 151

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*....
gi 2462594753  463 IWNVQKGKIIQRFNEHgTNGIFCIAWShKDSKRIATCSSDGfcIIRTID 511
Cdd:PTZ00421   152 VWDVERGKAVEVIKCH-SDQITSLEWN-LDGSLLCTTSKDK--KLNIID 196
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 73-112 4.22e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 41.91  E-value: 4.22e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 2462594753    73 FKLHAIMSEHKKTITAISWCPHNpDLFASGSTDNLVIIWN 112
Cdd:smart00320    2 GELLKTLKGHTGPVTSVAFSPDG-KYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 391-422 7.38e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 41.14  E-value: 7.38e-05
                            10        20        30
                    ....*....|....*....|....*....|..
gi 2462594753   391 GHVETIFDCKFKPDDpNLLATASFDGTIKVWD 422
Cdd:smart00320   10 GHTGPVTSVAFSPDG-KYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
391-422 1.52e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 40.41  E-value: 1.52e-04
                           10        20        30
                   ....*....|....*....|....*....|..
gi 2462594753  391 GHVETIFDCKFKPDDpNLLATASFDGTIKVWD 422
Cdd:pfam00400    9 GHTGSVTSLAFSPDG-KLLASGSDDGTVKVWD 39
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 559-632 1.88e-04

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 45.85  E-value: 1.88e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2462594753  559 GLMWNTEIPYLLISGSWDYTIKVWDTREGTCVDTVYDHGADVYGLTCHPSRPFTMASCSRDSTVRLWSLTALVT 632
Cdd:PLN00181   537 GICWNSYIKSQVASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSADPTLLASGSDDGSVKLWSINQGVS 610
WD40 pfam00400
WD domain, G-beta repeat;
587-626 2.25e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 39.64  E-value: 2.25e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 2462594753  587 GTCVDTVYDHGADVYGLTCHPSRPFtMASCSRDSTVRLWS 626
Cdd:pfam00400    1 GKLLKTLEGHTGSVTSLAFSPDGKL-LASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 587-626 2.29e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.60  E-value: 2.29e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 2462594753   587 GTCVDTVYDHGADVYGLTCHPSRPFtMASCSRDSTVRLWS 626
Cdd:smart00320    2 GELLKTLKGHTGPVTSVAFSPDGKY-LASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
73-112 1.14e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 37.71  E-value: 1.14e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 2462594753   73 FKLHAIMSEHKKTITAISWCPHNpDLFASGSTDNLVIIWN 112
Cdd:pfam00400    1 GKLLKTLEGHTGSVTSLAFSPDG-KLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 468-507 1.48e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 37.29  E-value: 1.48e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 2462594753   468 KGKIIQRFNEHgTNGIFCIAWSHkDSKRIATCSSDGFCII 507
Cdd:smart00320    1 SGELLKTLKGH-TGPVTSVAFSP-DGKYLASGSDDGTIKL 38
PTZ00420 PTZ00420
coronin; Provisional
 59-134 2.50e-03

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 41.86  E-value: 2.50e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462594753   59 LAIYIYQLDHR---YNEFK-LHAIMSEHKKTITAISWCPHNPDLFASGSTDNLVIIWNVAEQKVIAKLDSTKGIpASLSW 134
Cdd:PTZ00420    97 LTIRVWEIPHNdesVKEIKdPQCILKGHKKKISIIDWNPMNYYIMCSSGFDSFVNIWDIENEKRAFQINMPKKL-SSLKW 175
WD40 COG2319
WD40 repeat [General function prediction only];
535-644 2.51e-03

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 41.82  E-value: 2.51e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462594753  535 TVRIWDYTQDACINILNGHTAPVRGLMWNTEiPYLLISGSWDYTIKVWDTREGTCVDTVYDHGADVYGLTCHPSRPfTMA 614
Cdd:COG2319     17 ALALLAAALGALLLLLLGLAAAVASLAASPD-GARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGR-LLA 94

                           90       100       110
                   ....*....|....*....|....*....|
gi 2462594753  615 SCSRDSTVRLWSLTALVTPVQINILADRSW 644
Cdd:COG2319     95 SASADGTVRLWDLATGLLLRTLTGHTGAVR 124
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 37-174 5.03e-03

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 40.40  E-value: 5.03e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462594753   37 GCQPWNKDVCAASGDRFAYCATL--AIYIYQLdhryNEFKLHAIMSEHKKTITAISWCPhNPDLFASGSTDNLVIIWNVA 114
Cdd:cd00200    133 GHTDWVNSVAFSPDGTFVASSSQdgTIKLWDL----RTGKCVATLTGHTGEVNSVAFSP-DGEKLLSSSSDGTIKLWDLS 207

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462594753  115 EQKVIAKLDSTKGIPASLSWCWNaEDVVAFVSHRGPLFIW---------TISGPDSGVI---VHKDAHSFLS 174
Cdd:cd00200    208 TGKCLGTLRGHENGVNSVAFSPD-GYLLASGSEDGTIRVWdlrtgecvqTLSGHTNSVTslaWSPDGKRLAS 278
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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