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Conserved domains on  [gi|2462598470|ref|XP_054206607|]
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WD repeat-containing protein 19 isoform X1 [Homo sapiens]

Protein Classification

WD40 and WD40_3 domain-containing protein( domain architecture ID 11456978)

WD40 and WD40_3 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40_3 pfam15911
WD domain, G-beta repeat;
508-564 5.23e-30

WD domain, G-beta repeat;


:

Pssm-ID: 464937  Cd Length: 57  Bit Score: 113.07  E-value: 5.23e-30
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 2462598470  508 VNDYRHPVSVKKIFPDPNGTRLVFIDEKSDGFVYCPVNDATYEIPDFSPTIKGVLWE 564
Cdd:pfam15911    1 VNEYRHSVGIKKLFPNPSGTRLVFIDEKGDGFLYNPVSDELLEIPDFPPTVKGVLWD 57
WD40 COG2319
WD40 repeat [General function prediction only];
26-345 5.39e-12

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 69.55  E-value: 5.39e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462598470   26 GNYLAVTGADYIVKIFDRHGQK--RSEINLPGNCVAMDWDKDGDVLAVIAEKSScIYLWDANTNKTSQLDNGMRDQMSFL 103
Cdd:COG2319     90 GRLLASASADGTVRLWDLATGLllRTLTGHTGAVRSVAFSPDGKTLASGSADGT-VRLWDLATGKLLRTLTGHSGAVTSV 168

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462598470  104 LWSKVGSFLAVGTVKGNLLIYNHQTSRKIPVLGKHTKRITCGCWNAE-NLLALGGEDKMITVSN-QEGDTIRQTQVRSEP 181
Cdd:COG2319    169 AFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDgKLLASGSADGTVRLWDlATGKLLRTLTGHSGS 248

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462598470  182 SNmqfflmkmddrtSAAES----MISVVLGKKTLFFLNLNEPDNPADLEFQQDFGNIVCynWYGDGRIMIGFSCGHFV-V 256
Cdd:COG2319    249 VR------------SVAFSpdgrLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVA--FSPDGKLLASGSDDGTVrL 314

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462598470  257 ISTHTGELGQEIfqaRNHKDNLTSIAVSQTLNKVATCG-DNCIKiqdLVDLKDMYVILNLDEENKGLGTLSWTDDGQLLA 335
Cdd:COG2319    315 WDLATGKLLRTL---TGHTGAVRSVAFSPDGKTLASGSdDGTVR---LWDLATGELLRTLTGHTGAVTSVAFSPDGRTLA 388

                          330
                   ....*....|
gi 2462598470  336 LSTQRGSLHV 345
Cdd:COG2319    389 SGSADGTVRL 398
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 786-1004 5.51e-07

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


:

Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 52.81  E-value: 5.51e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462598470  786 AIQLEFAGDYVNALAHYEKGITGDNkEHDEACLAgVAQMSIRMGDIRRGV---NQALK-HPSRV-LKRDCGAILENMKQF 860
Cdd:COG2956     15 GLNYLLNGQPDKAIDLLEEALELDP-ETVEAHLA-LGNLYRRRGEYDRAIrihQKLLErDPDRAeALLELAQDYLKAGLL 92

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462598470  861 SEAAQLYEKGL--------YYDKAASVYIRSKNWAKVGDLL-----PHVSSPKIHLQYAKAKEADGRYKEAVVAYENA-- 925
Cdd:COG2956     93 DRAEELLEKLLeldpddaeALRLLAEIYEQEGDWEKAIEVLerllkLGPENAHAYCELAELYLEQGDYDEAIEALEKAlk 172

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462598470  926 KQWQSV------IRIYLDHlNNPEKAVNIVRET-----QSLDGAKMVARFFLQLGDYGSAIQFLvmskcnNEAFTLAQQH 994
Cdd:COG2956    173 LDPDCArallllAELYLEQ-GDYEEAIAALERAleqdpDYLPALPRLAELYEKLGDPEEALELL------RKALELDPSD 245

                          250
                   ....*....|
gi 2462598470  995 NKMEIYADII 1004
Cdd:COG2956    246 DLLLALADLL 255
 
Name Accession Description Interval E-value
WD40_3 pfam15911
WD domain, G-beta repeat;
508-564 5.23e-30

WD domain, G-beta repeat;


Pssm-ID: 464937  Cd Length: 57  Bit Score: 113.07  E-value: 5.23e-30
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 2462598470  508 VNDYRHPVSVKKIFPDPNGTRLVFIDEKSDGFVYCPVNDATYEIPDFSPTIKGVLWE 564
Cdd:pfam15911    1 VNEYRHSVGIKKLFPNPSGTRLVFIDEKGDGFLYNPVSDELLEIPDFPPTVKGVLWD 57
WD40 COG2319
WD40 repeat [General function prediction only];
26-345 5.39e-12

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 69.55  E-value: 5.39e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462598470   26 GNYLAVTGADYIVKIFDRHGQK--RSEINLPGNCVAMDWDKDGDVLAVIAEKSScIYLWDANTNKTSQLDNGMRDQMSFL 103
Cdd:COG2319     90 GRLLASASADGTVRLWDLATGLllRTLTGHTGAVRSVAFSPDGKTLASGSADGT-VRLWDLATGKLLRTLTGHSGAVTSV 168

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462598470  104 LWSKVGSFLAVGTVKGNLLIYNHQTSRKIPVLGKHTKRITCGCWNAE-NLLALGGEDKMITVSN-QEGDTIRQTQVRSEP 181
Cdd:COG2319    169 AFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDgKLLASGSADGTVRLWDlATGKLLRTLTGHSGS 248

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462598470  182 SNmqfflmkmddrtSAAES----MISVVLGKKTLFFLNLNEPDNPADLEFQQDFGNIVCynWYGDGRIMIGFSCGHFV-V 256
Cdd:COG2319    249 VR------------SVAFSpdgrLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVA--FSPDGKLLASGSDDGTVrL 314

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462598470  257 ISTHTGELGQEIfqaRNHKDNLTSIAVSQTLNKVATCG-DNCIKiqdLVDLKDMYVILNLDEENKGLGTLSWTDDGQLLA 335
Cdd:COG2319    315 WDLATGKLLRTL---TGHTGAVRSVAFSPDGKTLASGSdDGTVR---LWDLATGELLRTLTGHTGAVTSVAFSPDGRTLA 388

                          330
                   ....*....|
gi 2462598470  336 LSTQRGSLHV 345
Cdd:COG2319    389 SGSADGTVRL 398
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 26-302 4.52e-09

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 59.27  E-value: 4.52e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462598470   26 GNYLAVTGADYIVKIFDRHGQKRSEInLPG-----NCVamDWDKDGDVLAVIAEKSSCIyLWDANTNKTSQLDNGMRDQM 100
Cdd:cd00200     63 GTYLASGSSDKTIRLWDLETGECVRT-LTGhtsyvSSV--AFSPDGRILSSSSRDKTIK-VWDVETGKCLTTLRGHTDWV 138

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462598470  101 SFLLWSKVGSFLAVGTVKGNLLIYNHQTSRKIPVLGKHTKRITCGCWNAEN-LLALGGEDKMITVSN-QEGDTIRQtqvr 178
Cdd:cd00200    139 NSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGeKLLSSSSDGTIKLWDlSTGKCLGT---- 214

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462598470  179 sepsnmqfflmkmddrtsaaesmisvvlgkktlfflnlnepdnpadLEFQQDFGNIVCYNWygDGRIMIGFSC-GHFVVI 257
Cdd:cd00200    215 ----------------------------------------------LRGHENGVNSVAFSP--DGYLLASGSEdGTIRVW 246

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....*.
gi 2462598470  258 STHTGELGQEIfqaRNHKDNLTSIAVSQTLNKVATCG-DNCIKIQD 302
Cdd:cd00200    247 DLRTGECVQTL---SGHTNSVTSLAWSPDGKRLASGSaDGTIRIWD 289
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 786-1004 5.51e-07

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 52.81  E-value: 5.51e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462598470  786 AIQLEFAGDYVNALAHYEKGITGDNkEHDEACLAgVAQMSIRMGDIRRGV---NQALK-HPSRV-LKRDCGAILENMKQF 860
Cdd:COG2956     15 GLNYLLNGQPDKAIDLLEEALELDP-ETVEAHLA-LGNLYRRRGEYDRAIrihQKLLErDPDRAeALLELAQDYLKAGLL 92

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462598470  861 SEAAQLYEKGL--------YYDKAASVYIRSKNWAKVGDLL-----PHVSSPKIHLQYAKAKEADGRYKEAVVAYENA-- 925
Cdd:COG2956     93 DRAEELLEKLLeldpddaeALRLLAEIYEQEGDWEKAIEVLerllkLGPENAHAYCELAELYLEQGDYDEAIEALEKAlk 172

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462598470  926 KQWQSV------IRIYLDHlNNPEKAVNIVRET-----QSLDGAKMVARFFLQLGDYGSAIQFLvmskcnNEAFTLAQQH 994
Cdd:COG2956    173 LDPDCArallllAELYLEQ-GDYEEAIAALERAleqdpDYLPALPRLAELYEKLGDPEEALELL------RKALELDPSD 245

                          250
                   ....*....|
gi 2462598470  995 NKMEIYADII 1004
Cdd:COG2956    246 DLLLALADLL 255
CLH smart00299
Clathrin heavy chain repeat homology;
855-968 1.17e-03

Clathrin heavy chain repeat homology;


Pssm-ID: 128594 [Multi-domain]  Cd Length: 140  Bit Score: 40.72  E-value: 1.17e-03
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462598470   855 ENMKQFSEAAQLYekgLYYDKAASV-YIRSKNwakvgdllPHVSSPKIhlqYAKAKEADGrYKEAVVAYENAKQWQSVIR 933
Cdd:smart00299   39 ENPALQTKLIELY---AKYDPQKEIeRLDNKS--------NHYDIEKV---GKLCEKAKL-YEEAVELYKKDGNFKDAIV 103

                            90       100       110
                    ....*....|....*....|....*....|....*
gi 2462598470   934 IYLDHLNNPEKAVNIVRETQSLDGAKMVARFFLQL 968
Cdd:smart00299  104 TLIEHLGNYEKAIEYFVKQNNPELWAEVLKALLDK 138
 
Name Accession Description Interval E-value
WD40_3 pfam15911
WD domain, G-beta repeat;
508-564 5.23e-30

WD domain, G-beta repeat;


Pssm-ID: 464937  Cd Length: 57  Bit Score: 113.07  E-value: 5.23e-30
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 2462598470  508 VNDYRHPVSVKKIFPDPNGTRLVFIDEKSDGFVYCPVNDATYEIPDFSPTIKGVLWE 564
Cdd:pfam15911    1 VNEYRHSVGIKKLFPNPSGTRLVFIDEKGDGFLYNPVSDELLEIPDFPPTVKGVLWD 57
WD40 COG2319
WD40 repeat [General function prediction only];
26-345 5.39e-12

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 69.55  E-value: 5.39e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462598470   26 GNYLAVTGADYIVKIFDRHGQK--RSEINLPGNCVAMDWDKDGDVLAVIAEKSScIYLWDANTNKTSQLDNGMRDQMSFL 103
Cdd:COG2319     90 GRLLASASADGTVRLWDLATGLllRTLTGHTGAVRSVAFSPDGKTLASGSADGT-VRLWDLATGKLLRTLTGHSGAVTSV 168

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462598470  104 LWSKVGSFLAVGTVKGNLLIYNHQTSRKIPVLGKHTKRITCGCWNAE-NLLALGGEDKMITVSN-QEGDTIRQTQVRSEP 181
Cdd:COG2319    169 AFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDgKLLASGSADGTVRLWDlATGKLLRTLTGHSGS 248

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462598470  182 SNmqfflmkmddrtSAAES----MISVVLGKKTLFFLNLNEPDNPADLEFQQDFGNIVCynWYGDGRIMIGFSCGHFV-V 256
Cdd:COG2319    249 VR------------SVAFSpdgrLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVA--FSPDGKLLASGSDDGTVrL 314

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462598470  257 ISTHTGELGQEIfqaRNHKDNLTSIAVSQTLNKVATCG-DNCIKiqdLVDLKDMYVILNLDEENKGLGTLSWTDDGQLLA 335
Cdd:COG2319    315 WDLATGKLLRTL---TGHTGAVRSVAFSPDGKTLASGSdDGTVR---LWDLATGELLRTLTGHTGAVTSVAFSPDGRTLA 388

                          330
                   ....*....|
gi 2462598470  336 LSTQRGSLHV 345
Cdd:COG2319    389 SGSADGTVRL 398
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 26-302 4.52e-09

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 59.27  E-value: 4.52e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462598470   26 GNYLAVTGADYIVKIFDRHGQKRSEInLPG-----NCVamDWDKDGDVLAVIAEKSSCIyLWDANTNKTSQLDNGMRDQM 100
Cdd:cd00200     63 GTYLASGSSDKTIRLWDLETGECVRT-LTGhtsyvSSV--AFSPDGRILSSSSRDKTIK-VWDVETGKCLTTLRGHTDWV 138

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462598470  101 SFLLWSKVGSFLAVGTVKGNLLIYNHQTSRKIPVLGKHTKRITCGCWNAEN-LLALGGEDKMITVSN-QEGDTIRQtqvr 178
Cdd:cd00200    139 NSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGeKLLSSSSDGTIKLWDlSTGKCLGT---- 214

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462598470  179 sepsnmqfflmkmddrtsaaesmisvvlgkktlfflnlnepdnpadLEFQQDFGNIVCYNWygDGRIMIGFSC-GHFVVI 257
Cdd:cd00200    215 ----------------------------------------------LRGHENGVNSVAFSP--DGYLLASGSEdGTIRVW 246

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....*.
gi 2462598470  258 STHTGELGQEIfqaRNHKDNLTSIAVSQTLNKVATCG-DNCIKIQD 302
Cdd:cd00200    247 DLRTGECVQTL---SGHTNSVTSLAWSPDGKRLASGSaDGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 59-346 6.86e-09

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 58.89  E-value: 6.86e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462598470   59 AMDWDKDGDVLAVIAEkSSCIYLWDANTNKTSQLDNGMRDQMSFLLWSKVGSFLAVGTVKGNLLIYNHQTSRKIPVLGKH 138
Cdd:cd00200     14 CVAFSPDGKLLATGSG-DGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRTLTGH 92

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462598470  139 TKRITCGCWNAEN-LLALGGEDKmitvsnqegdTIRqtqvrsepsnmqfflmkmddrtsaaesmisvvlgkktlfFLNLN 217
Cdd:cd00200     93 TSYVSSVAFSPDGrILSSSSRDK----------TIK---------------------------------------VWDVE 123

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462598470  218 EPDNPADLEFQQDFGNIVCYNwyGDGRIMIGFSCGHFV-VISTHTGELGQEIfqaRNHKDNLTSIAVSQTLNKVATCG-D 295
Cdd:cd00200    124 TGKCLTTLRGHTDWVNSVAFS--PDGTFVASSSQDGTIkLWDLRTGKCVATL---TGHTGEVNSVAFSPDGEKLLSSSsD 198

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|.
gi 2462598470  296 NCIKIQDLVDLKDMYVilnLDEENKGLGTLSWTDDGQLLALSTQRGSLHVF 346
Cdd:cd00200    199 GTIKLWDLSTGKCLGT---LRGHENGVNSVAFSPDGYLLASGSEDGTIRVW 246
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 25-157 9.78e-09

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 58.12  E-value: 9.78e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462598470   25 SGNYLAVTGADYIVKIFD-RHGQKRSEINL---PGNCVAMDWDKDgdvLAVIAEKSSCIYLWDANTNKTSQLDNGMRDQM 100
Cdd:cd00200    104 DGRILSSSSRDKTIKVWDvETGKCLTTLRGhtdWVNSVAFSPDGT---FVASSSQDGTIKLWDLRTGKCVATLTGHTGEV 180

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 2462598470  101 SFLLWSKVGSFLAVGTVKGNLLIYNHQTSRKIPVLGKHTKRITCGCWNAENLLALGG 157
Cdd:cd00200    181 NSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASG 237
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 25-162 3.09e-08

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 56.57  E-value: 3.09e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462598470   25 SGNYLAVTGADYIVKIFDRHGQKRSEiNLPG-----NCVAmdWDKDGDVLAVIAEkSSCIYLWDANTNKTSQLDNGMRDQ 99
Cdd:cd00200    146 DGTFVASSSQDGTIKLWDLRTGKCVA-TLTGhtgevNSVA--FSPDGEKLLSSSS-DGTIKLWDLSTGKCLGTLRGHENG 221

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2462598470  100 MSFLLWSKVGSFLAVGTVKGNLLIYNHQTSRKIPVLGKHTKRITCGCWNAE-NLLALGGEDKMI 162
Cdd:cd00200    222 VNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDgKRLASGSADGTI 285
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 786-1004 5.51e-07

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 52.81  E-value: 5.51e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462598470  786 AIQLEFAGDYVNALAHYEKGITGDNkEHDEACLAgVAQMSIRMGDIRRGV---NQALK-HPSRV-LKRDCGAILENMKQF 860
Cdd:COG2956     15 GLNYLLNGQPDKAIDLLEEALELDP-ETVEAHLA-LGNLYRRRGEYDRAIrihQKLLErDPDRAeALLELAQDYLKAGLL 92

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462598470  861 SEAAQLYEKGL--------YYDKAASVYIRSKNWAKVGDLL-----PHVSSPKIHLQYAKAKEADGRYKEAVVAYENA-- 925
Cdd:COG2956     93 DRAEELLEKLLeldpddaeALRLLAEIYEQEGDWEKAIEVLerllkLGPENAHAYCELAELYLEQGDYDEAIEALEKAlk 172

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462598470  926 KQWQSV------IRIYLDHlNNPEKAVNIVRET-----QSLDGAKMVARFFLQLGDYGSAIQFLvmskcnNEAFTLAQQH 994
Cdd:COG2956    173 LDPDCArallllAELYLEQ-GDYEEAIAALERAleqdpDYLPALPRLAELYEKLGDPEEALELL------RKALELDPSD 245

                          250
                   ....*....|
gi 2462598470  995 NKMEIYADII 1004
Cdd:COG2956    246 DLLLALADLL 255
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 673-925 3.06e-06

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 50.50  E-value: 3.06e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462598470  673 NDEAAWNELARACLHHMEVEFAIRVYRRIgnvgivmsLEQIKGIEDYNLLAGHLAMFTNDYNLAQDLY--LASSCP--IA 748
Cdd:COG2956     40 ETVEAHLALGNLYRRRGEYDRAIRIHQKL--------LERDPDRAEALLELAQDYLKAGLLDRAEELLekLLELDPddAE 111

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462598470  749 ALEVWQQMRRDLQHWDSALQLAKHLAP--DQIPFISKEYAIQLEFAGDYVNALAHYEKGITgDNKEHDEACLAgVAQMSI 826
Cdd:COG2956    112 ALRLLAEIYEQEGDWEKAIEVLERLLKlgPENAHAYCELAELYLEQGDYDEAIEALEKALK-LDPDCARALLL-LAELYL 189

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462598470  827 RMGDirrgVNQALKHPSRVLKRDcgaiLENMKQFSEAAQLYEKGLYYDKAASVYIRsknwakvgdLLPHVSSPKIHLQYA 906
Cdd:COG2956    190 EQGD----YEEAIAALERALEQD----PDYLPALPRLAELYEKLGDPEEALELLRK---------ALELDPSDDLLLALA 252

                          250
                   ....*....|....*....
gi 2462598470  907 KAKEADGRYKEAVVAYENA 925
Cdd:COG2956    253 DLLERKEGLEAALALLERQ 271
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 719-967 9.92e-06

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 49.99  E-value: 9.92e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462598470  719 YNLLAGHLAMFTNDYNLAQDLYLASSCPIAALEVWQQMRRDLQHWDSALQLAKHLAPDQIPFISKEYAIQLEfAGDYVNA 798
Cdd:COG3914     19 AAAAAAELALAAELEAAALAAALGLALLLLAALAEAAAAALLALAAGEAAAAAAALLLLAALLELAALLLQA-LGRYEEA 97

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462598470  799 LAHYEKGITGDNKEHDEACLAGVAQMsiRMGDIrrgvNQALKHPSRVLKRD---------CGAILENMKQFSEAAQLYEK 869
Cdd:COG3914     98 LALYRRALALNPDNAEALFNLGNLLL--ALGRL----EEALAALRRALALNpdfaeaylnLGEALRRLGRLEEAIAALRR 171

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462598470  870 GLyydkaasvyirsknwakvgDLLPHvsSPKIHLQYAKAKEADGRYKEAVVAYENAKQ--------WQSVIRIYLDHLNN 941
Cdd:COG3914    172 AL-------------------ELDPD--NAEALNNLGNALQDLGRLEEAIAAYRRALEldpdnadaHSNLLFALRQACDW 230

                          250       260
                   ....*....|....*....|....*.
gi 2462598470  942 PEKAVNIVRETQSLDGAKMVARFFLQ 967
Cdd:COG3914    231 EVYDRFEELLAALARGPSELSPFALL 256
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 784-927 2.01e-04

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 42.87  E-value: 2.01e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462598470  784 EYAIQLEFAGDYVNALAHYEKGITgDNKEHDEAcLAGVAQMSIRMGDIRRGV---NQALK-HP-SRVLKRDCGAILENMK 858
Cdd:COG4783      9 ALAQALLLAGDYDEAEALLEKALE-LDPDNPEA-FALLGEILLQLGDLDEAIvllHEALElDPdEPEARLNLGLALLKAG 86

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2462598470  859 QFSEAAQLYEKGLYYDKaasvyirsknwakvgdllphvSSPKIHLQYAKAKEADGRYKEAVVAYENAKQ 927
Cdd:COG4783     87 DYDEALALLEKALKLDP---------------------EHPEAYLRLARAYRALGRPDEAIAALEKALE 134
COG4700 COG4700
Uncharacterized conserved protein ECs_4300, contains TPR-like domain [Function unknown];
851-925 2.65e-04

Uncharacterized conserved protein ECs_4300, contains TPR-like domain [Function unknown];


Pssm-ID: 443735 [Multi-domain]  Cd Length: 249  Bit Score: 44.10  E-value: 2.65e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462598470  851 GAILENMKQFSEAAQLYEK---GLYYD------KAASVYIRSKNWAKVGDLL-------PHVSSPKIHLQYAKAKEADGR 914
Cdd:COG4700     96 ADALLELGRYDEAIELYEEaltGIFADdphillGLAQALFELGRYAEALETLekliaknPDFKSSDAHLLYARALEALGD 175

                           90
                   ....*....|.
gi 2462598470  915 YKEAVVAYENA 925
Cdd:COG4700    176 LEAAEAELEAL 186
COG5290 COG5290
IkappaB kinase complex, IKAP component [Transcription];
836-934 4.81e-04

IkappaB kinase complex, IKAP component [Transcription];


Pssm-ID: 227610 [Multi-domain]  Cd Length: 1243  Bit Score: 44.61  E-value: 4.81e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462598470  836 NQALKHpsrvLKRDCGAILENMKqFSEAAQLYEKGLYYDKaasvYIRSKNWAKVGDLLPHVSSPKIHLQYAKAKEADGRY 915
Cdd:COG5290    881 ESALGH----LNEDLNVIREVMK-YICRHDLYDFLLLLYR----YDGELQKFKINIFAGNLVDNLYHISAAKAYEVEGKY 951

                           90
                   ....*....|....*....
gi 2462598470  916 KEAVVAYENAKQWQSVIRI 934
Cdd:COG5290    952 IEAHGAYDSALMWRECGSI 970
CLH smart00299
Clathrin heavy chain repeat homology;
855-968 1.17e-03

Clathrin heavy chain repeat homology;


Pssm-ID: 128594 [Multi-domain]  Cd Length: 140  Bit Score: 40.72  E-value: 1.17e-03
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462598470   855 ENMKQFSEAAQLYekgLYYDKAASV-YIRSKNwakvgdllPHVSSPKIhlqYAKAKEADGrYKEAVVAYENAKQWQSVIR 933
Cdd:smart00299   39 ENPALQTKLIELY---AKYDPQKEIeRLDNKS--------NHYDIEKV---GKLCEKAKL-YEEAVELYKKDGNFKDAIV 103

                            90       100       110
                    ....*....|....*....|....*....|....*
gi 2462598470   934 IYLDHLNNPEKAVNIVRETQSLDGAKMVARFFLQL 968
Cdd:smart00299  104 TLIEHLGNYEKAIEYFVKQNNPELWAEVLKALLDK 138
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
793-925 3.86e-03

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 40.76  E-value: 3.86e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462598470  793 GDYVNALAHYEKGITGDNKEHDEACLAGVAQMsiRMGDIRrgvnQALKHPSRVLKRD---------CGAILENMKQFSEA 863
Cdd:COG0457     22 GRYEEAIEDYEKALELDPDDAEALYNLGLAYL--RLGRYE----EALADYEQALELDpddaealnnLGLALQALGRYEEA 95

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462598470  864 AQLYEKGLyydkaasvyirsknwakvgDLLPhvSSPKIHLQYAKAKEADGRYKEAVVAYENA 925
Cdd:COG0457     96 LEDYDKAL-------------------ELDP--DDAEALYNLGLALLELGRYDEAIEAYERA 136
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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