|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_MFSD7 |
cd17399 |
Major facilitator superfamily domain-containing protein 7; Major facilitator superfamily ... |
1-378 |
3.73e-179 |
|
Major facilitator superfamily domain-containing protein 7; Major facilitator superfamily domain-containing protein 7 (MFSD7) is also called myosin light polypeptide 5 regulatory protein (MYL5). It's function is unknown. It is encoded by the a SLC49A3 gene and is a member of the Solute carrier 49 (SLC49) family, which also includes feline leukemia virus subgroup C receptor 1 (FLVCR1, SLC49A1), FLVCR2 (SLC49A2), as well as disrupted in renal carcinoma protein 2 (DIRC2, SLC49A4). FLVCR1 and FLVCR2 are heme transporters. DIRC2 is an electrogenic lysosomal metabolite transporter that is regulated by limited proteolytic processing by cathepsin L. MFSD7 belongs to the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340957 Cd Length: 419 Bit Score: 508.73 E-value: 3.73e-179
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462599290 1 MEQINWLSLVYLVVSTPFGVAAIWILDSVGLRAATILGAWLNFAGSVLRMVPCM-VVGTQNPFAFLMGGQSLCALAQSLV 79
Cdd:cd17399 38 LDAVNWLSLIYMIVSIPVGFVAMWLLDTLGLRTAIILGAWLNFIGAVIRVISSLpFVDPSFRFPVLMTGQTLAAFAQPFI 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462599290 80 IFSPAKLAALWFPEHQRATANMLATMSNPLGVLVANVLSPVLVKKGEDIPLMLGVYTIPAGVVCLLSTICLWESVPPTPP 159
Cdd:cd17399 118 LFLPTKLAALWFPDNQRAIANMLASMSNPLGVLLANLLSPLIVKSSEDIFLLLSIYTIPALIAVVLATFGVRSSVPPTPP 197
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462599290 160 SAGAASStSEKFLDGLKlQLMWNKAYVILAVCLGGMIGISASFSALLEQILCASGHSSGFSGLCGALFITFGILGALALG 239
Cdd:cd17399 198 SASAAHE-SEPFFVGLK-QLFKNKQYLILMLCFGGGIGLFNALSTLLEQILCPSGYSNNFAGICGALMIGVGLIGAFVAG 275
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462599290 240 PYVDRTKHFTEATKIGLCLFSLACVPFALVSQLQGQTLALAATCSLLGLFGFSVGPVAMELAVECSFPVGEGAATGMIFV 319
Cdd:cd17399 276 LIVDKTKKFIEVTKVCFCLAVIFLVAFLVVSRFPNQSVLLAVLCGLFGFFGFAIYPVGLELAVECTYPVAEATSTGLIFM 355
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2462599290 320 LGQAEGILIMLAMTALTVRRSEPSL-----STCQQGEDPLDWTVSLLLMAGLCTFFSCILAVFF 378
Cdd:cd17399 356 SGQIQGIILVFIMQALATPLSVYDLpiqcaSSASGNITPLDWTVPLLVMAGLAAVLAIIFVVFF 419
|
|
| MFS_SLC49 |
cd17334 |
Solute carrier 49 (SLC49) family of the Major Facilitator Superfamily of transporters; The ... |
1-378 |
1.45e-137 |
|
Solute carrier 49 (SLC49) family of the Major Facilitator Superfamily of transporters; The Solute carrier 49 (SLC49) family is composed of four members: feline leukemia virus subgroup C receptor 1 (FLVCR1, SLC49A1); FLVCR2 (SLC49A2); major facilitator superfamily domain-containing protein 7 (MFSD7, SLC49A3); and disrupted in renal carcinoma protein 2 (DIRC2, SLC49A4). FLVCR1 and FLVCR2 are heme transporters. In addition, FLVCR2 also functions as a transporter for a calcium-chelator complex that is important for growth and calcium metabolism. The function of MFSD7 is unknown. DIRC2 is an electrogenic lysosomal metabolite transporter that is regulated by limited proteolytic processing by cathepsin L. The SLC49 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340892 [Multi-domain] Cd Length: 407 Bit Score: 402.55 E-value: 1.45e-137
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462599290 1 MEQINWLSLVYLVVSTPFGVAAIWILDSVGLRAATILGAWLNFAGSVLRMVPCmvvGTQNPFAFLMGGQSLCALAQSLVI 80
Cdd:cd17334 38 ASQINWLSLVYPIVYVPGVFAFCWLLDKVGLRIGVLIGAALNALGSVLKCIPL---GQQPKFALLVLGQVLNALAQVLVL 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462599290 81 FSPAKLAALWFPEHQRATANMLATMSNPLGVLVANVLSPVLVKKGED-IPLMLGVYTIPAGVVCLLSTICLWESVPPTPP 159
Cdd:cd17334 115 SLPPLIAAVWFPPKERTTATAIASLANFLGCAIGFLLPPVVVPPPKGtKKEFGAVFYGEFGFACLLLALVLALFPPKPKY 194
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462599290 160 SAGAASSTSEK------FLDGLKLQLMWNKAYVILAVCLGGMIGISASFSALLEQILCASGHSSGFSGLCGALFITFGIL 233
Cdd:cd17334 195 PPSAASARQQNsehvilELQKSISELLRNEPFVLLAVAFSIMMGVFAGFSSVLAQILLPFGVSQTSAGWLGFFGIVAGMV 274
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462599290 234 GALALGPYVDRTKHFTEATKIGLCLFSLACVPFALVSQ---LQGQTLALAATCSLLGLFGFSVGPVAMELAVECSFPVGE 310
Cdd:cd17334 275 GGLLLGLFVDRTRMFKLIGLIILALGTVVCTFFMLLVDrygLPYVTLAFYLLCGLLGFFQNSMVPIMFELAVELTYPVPE 354
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2462599290 311 GAATGMIFVLGQAEGILIMLAMTALTVrrsepslstcqqgedPLDWTVSLLLMAGLCTFFSCILAVFF 378
Cdd:cd17334 355 SVSTGVLTALANLFSFLLMLVFSELLG---------------PTPTESKYLLWFILCTVGSCLGALFF 407
|
|
| MFS_FLVCR_like |
cd17398 |
Feline leukemia virus subgroup C receptor subfamily of the Major Facilitator Superfamily of ... |
4-335 |
2.47e-53 |
|
Feline leukemia virus subgroup C receptor subfamily of the Major Facilitator Superfamily of transporters; The Feline leukemia virus subgroup C receptor (FLVCR) subfamily is conserved in metazoans and is composed of two vertebrate members, FLVCR1 and FLVCR2. FLVCR1 is a heme transporter and it has two isoforms: 1 (or FLVCR1a), which exports cytoplasmic heme as well as coproporphyrin and protoporphyrin IX; and 2 (FLVCR1b), which promotes heme efflux from the mitochondrion to the cytoplasm. FLVCR2 functions as a heme importer as well as a transporter for a calcium-chelator complex that is important for growth and calcium metabolism. The FLVCR subfamily belongs to the Solute carrier 49 (SLC49) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340956 [Multi-domain] Cd Length: 406 Bit Score: 184.75 E-value: 2.47e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462599290 4 INWLSLVYLVVSTPFGVAAIWILDSVGLRAATILGAWLNFAGSVLRmvpCMVVGTqNPFAFLMGGQSLCALAQSLVIFSP 83
Cdd:cd17398 41 VDWTSMIYMLTYIPLIFPATWLLEKYGLRVTVLLGSFLNCLGAWLK---LFSSSP-DLFWVAMAGQTICALAQVFILGIP 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462599290 84 AKLAALWFPEHQRATANMLATMSNPLGVLVANVLSPVLVKKGEDIP-----LMLGVYTIPA-GVVCLLSTICLWESVPPT 157
Cdd:cd17398 117 PRLAAVWFGPDEVSTATAIGVFGNQLGVALGFVLPPLLVPNSENKDeigkgLSILFYGVAGiCTALFILVIIFFKEKPPI 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462599290 158 PPSAGAASSTSEK-----FLDGLKlQLMWNKAYVILAVCLGGMIGISASFSALLEQ-ILCASGHSSGFSGLCGALFITFG 231
Cdd:cd17398 197 PPSRAQAAAQELRsedqsYLGSLK-RLFKNKGFLLLLITYGINTGVYYAISTLLNQmVLEYFPNEEVNAGWIGLTLVIAG 275
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462599290 232 ILGALALGPYVDRTKHFTEATkIGLCLFSLACVPFALVSQLQGQTLALAATCSLLGLFGFSVGPVAMELAVECSFPVGEG 311
Cdd:cd17398 276 LVGSVVAGIWLDKTKKYKETT-IIVYILSFIGMVAFTFTLDLGSIWVVFLTAGALGFFMTGYLPVGFEFAAELTYPEPEG 354
|
330 340
....*....|....*....|....
gi 2462599290 312 AATGMIFVLGQAEGILIMLAMTAL 335
Cdd:cd17398 355 TSSGLLNASAQIFGIIFTLVMGAL 378
|
|
| MFS_DIRC2 |
cd17397 |
Disrupted in renal carcinoma protein 2 of the Major Facilitator Superfamily of transporters; ... |
5-333 |
1.58e-36 |
|
Disrupted in renal carcinoma protein 2 of the Major Facilitator Superfamily of transporters; Disrupted in renal carcinoma protein 2 or disrupted in renal cancer protein 2 (DIRC2), encoded by the SLC49A4 gene, was initially identified as a breakpoint-spanning gene in a chromosomal translocation associated with the development of renal cancer. It is an electrogenic lysosomal metabolite transporter that is regulated by limited proteolytic processing by cathepsin L. DIRC2 belongs to the Solute carrier 49 (SLC49) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340955 [Multi-domain] Cd Length: 381 Bit Score: 138.97 E-value: 1.58e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462599290 5 NWLSLVYLVVSTPFgvaaIWILDSVGLRAATILGAWLNFAGSVLRMVPcmvvgTQNPFAFLM--GGQSLCALAQSLVIFS 82
Cdd:cd17397 46 NWGPIGFVPTFFFM----AWLMDVKGLRIAVLSSAFLVAAGTGLRCIP-----VPNHLATWLihIGQFLNGLAGPVAMAA 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462599290 83 PAKLAALWFPEHQRATANMLATMSNPLGVLVANVLSpvlvkkgediPLMLGVYTIPAGVVCLLSTICLWESVPPTPPSAg 162
Cdd:cd17397 117 APFLSATWFPPNQRATATAIASIFNYLGGAASFLIG----------PLVLMYLEFGWSALIFLAMLIYFPSKPPTPPSV- 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462599290 163 AASSTSEKFLDGLkLQLMWNKAYVILAVCLGGMIGISASFSALLEQILCASGHSSGFSGLCGALFITFGILGALALGPYV 242
Cdd:cd17397 186 SASTQRLSYKSGI-LSLLKNKRFWLIALAYGIPTGVYAGWSGVLDVNLTPFGVSQVEAGWIGFYSTVAGCVGGIIVGRFA 264
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462599290 243 DRTKHFTEatKIGLCLFSLACVPFALVSQLQ-----GQTLALAATCSLLGLFGFSVGPVAMELAVECSFPVGEGAATGMI 317
Cdd:cd17397 265 DRFGGRMK--LILLLLFSGATGSFLWFTLIClkllpFSTVSLYTSCILLGVFLNGSVPLFYELAVEAAYPVPEGITSGVL 342
|
330
....*....|....*.
gi 2462599290 318 FVLGQAEGILIMLAMT 333
Cdd:cd17397 343 TFLNNVFGLVFLLILI 358
|
|
| MFS_FLVCR1 |
cd17455 |
Feline leukemia virus subgroup C receptor-related protein 1 of the Major Facilitator ... |
3-336 |
5.77e-36 |
|
Feline leukemia virus subgroup C receptor-related protein 1 of the Major Facilitator Superfamily of transporters; Feline leukemia virus subgroup C receptor-related protein 1 (FLVCR1) is also called feline leukemia virus subgroup C receptor (FLVCR). FLVCR1 is a heme transporter and it has two isoforms: 1 (or FLVCR1a), which exports cytoplasmic heme as well as coproporphyrin and protoporphyrin IX; and 2 (FLVCR1b), which promotes heme efflux from the mitochondrion to the cytoplasm. Mutations in the FLVCR1 gene have been linked to vision impairment, posterior column ataxia, and sensory neurodegeneration with loss of pain perception. FLVCR1 belongs to the Solute carrier 49 (SLC49) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341013 Cd Length: 407 Bit Score: 138.04 E-value: 5.77e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462599290 3 QINWLSLVYLVVSTPFGVAAIWILDSVGLRAATILGAWLNFAGSVLRmvpCMVVGtQNPFAFLMGGQSLCALAQSLVIFS 82
Cdd:cd17455 40 AIDWLSVVYMVAYVPLIFPATWLLDLKGLRVTALLGAGLNCLGAWVK---CASVR-PDLFGVTMLAQVLCSVAQVFILGL 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462599290 83 PAKLAALWFPEHQRATANMLATMSNPLGVLVANVLSPVLVKK--------GEDIPLMLGVYTIPAGVVCLLsTICLWESV 154
Cdd:cd17455 116 PSRIASVWFGPREVSTACAVAVLGNQLGTAIGFLLPPVLVPNtvddidlmGHNISIMFYGTAAVSTLLFIL-TIIVFKEK 194
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462599290 155 PPTPPSAGAA---SSTSEKFLDGLKL-QLMWNKAYVILAVCLGGMIGISASFSALLEQILCAsgHSSG---FSGLCGALF 227
Cdd:cd17455 195 PPLPPSQAQAvlqGIPSEDYSYKQSIiNLFKNVPFVLLLISYGIMTGTFYSVSTLLNQMIIT--HYEGeevNAGRIGLTL 272
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462599290 228 ITFGILGALALGPYVDRTKHFTEATKIGLCLFSLACVPFALVSQLqGQTLALAATCSLLGLFGFSVGPVAMELAVECSFP 307
Cdd:cd17455 273 VVAGMVGSILCGLWLDYTKTYKQTTLIVYILSFIGMVVFTFTLDL-GYLIVVFVTGGVLGFFMTGYLPLGFEFAVEITYP 351
|
330 340
....*....|....*....|....*....
gi 2462599290 308 VGEGAATGMIFVLGQAEGILIMLAMTALT 336
Cdd:cd17455 352 ESEGTSSGLLNASAQIFGIIFTLIQGKLT 380
|
|
| MFS_FLVCR2 |
cd17456 |
Feline leukemia virus subgroup C receptor-related protein 2 of the Major Facilitator ... |
4-331 |
1.01e-30 |
|
Feline leukemia virus subgroup C receptor-related protein 2 of the Major Facilitator Superfamily of transporters; Feline leukemia virus subgroup C receptor-related protein 2 (FLVCR2) is also called calcium-chelate transporter (CCT). It functions as a heme importer as well as a transporter for a calcium-chelator complex that is important for growth and calcium metabolism. Mutations in the FLVCR2 gene cause Proliferative vasculopathy and hydranencephaly-hydrocephaly syndrome (PVHH), also known as Fowler syndrome, a rare autosomal recessive disorder characterized by glomerular vasculopathy in the central nervous system, severe hydrocephaly, hypokinesia and arthrogryphosis. FLVCR2 belongs to the Solute carrier 49 (SLC49) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341014 Cd Length: 406 Bit Score: 123.35 E-value: 1.01e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462599290 4 INWLSLVYLVVSTPFGVAAIWILDSVGLRAATILGAWLNFAGSVLRmvpcmvVGTQNP--FAFLMGGQSLCALAQSLVIF 81
Cdd:cd17456 41 IDWLSMSYMLTYIPLIFPVAWLLDKRGLRVIALVGSALNCLGAWIK------TGSARPdlFPVTVLGQLVCSVAQVFILG 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462599290 82 SPAKLAALWFPEHQRATANMLATMSNPLGVLVANVLSPVLVKKGEDIPLMLG----VYTIPAGVVCLLS--TICLWESVP 155
Cdd:cd17456 115 MPSRIASVWFGSSEVSTACSIGVFGNQLGVAIGFLLPPVLVPNIDDLDELAYhisiMFYGTAAVATLLFilVIIVFQEKP 194
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462599290 156 PTPPS---AGAASSTSEKF-LDGLKLQLMWNKAYVILAVCLGGMIGISASFSALLEQILCAsgHSSG---FSGLCGALFI 228
Cdd:cd17456 195 KIPPSqaqAAIQSIPSQDYsYLQSILRLLKNVNFILLVVSYGLNTGCFYALSTLLNRMVIF--HYPGeevNAGRIGLTIV 272
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462599290 229 TFGILGALALGPYVDRTKHFTEATkIGLCLFSLA-CVPFALVSQLqGQTLALAATCSLLGLFGFSVGPVAMELAVECSFP 307
Cdd:cd17456 273 VAGMVGALISGIWLDRTKTYKQTT-LAVYIMSLVgMVVYTFTLNL-GHLWVVFITAGTLGFFMTGYLPLGFEFAAELTYP 350
|
330 340
....*....|....*....|....
gi 2462599290 308 VGEGAATGMIFVLGQAEGILIMLA 331
Cdd:cd17456 351 ESEGTSSGLLNVSAQVFGIIFTIS 374
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
3-338 |
2.42e-14 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 74.39 E-value: 2.42e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462599290 3 QINWLSLVYLVVSTPFGVAAIWILDSVGLRAATILGAWLNFAGSVLRMVPcmvvgtqNPFAFLMGGQSLCALAQSLVIFS 82
Cdd:cd06174 32 QLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFA-------PSFWLLLLGRFLLGLGSGLIDPA 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462599290 83 PAKLAALWFPEHQRATANMLATMSNPLGVLVANVLSPVLVKKGEDI-PLMLGVYTIPAGVVCLLSTIClwesvPPTPPSA 161
Cdd:cd06174 105 VLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGFGwRAVFLIAAALALLAAILLLLV-----VPDPPES 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462599290 162 GAASSTSEKFLDGLKLQLMW--NKAYVILAVCLGGMIGISASFSALLEQILCASGHSSG-FSGLCGALFITFGILGALAL 238
Cdd:cd06174 180 ARAKNEEASSKSVLKLLKRVlkNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVaVAGLLLSLFGLAGALGSLLL 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462599290 239 GPYVDRtkHFTEATKIGLCLFSLACVPFALVsqLQGQTLALAATCSLLGLFGFSVGPVAMELAVECSFPVGEGAATGMIF 318
Cdd:cd06174 260 GLLSDR--LIGRKPLLLIGLLLMALGLALLL--LAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLN 335
|
330 340
....*....|....*....|
gi 2462599290 319 VLGQAEGILIMLAMTALTVR 338
Cdd:cd06174 336 TFGFLGGAIGPLLAGFLLAA 355
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
3-335 |
7.66e-14 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 72.99 E-value: 7.66e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462599290 3 QINWLSLVYLVVSTPFGVAAIWILDSVGLRAATILGAwlnfagsVLRMVPCMVVGTQNPFAFLMGGQSLCALAQSLVIFS 82
Cdd:COG2223 41 QLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGL-------LLLGIGLLLLALAVSYWLLLLLGLLLGIGGGGSFAV 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462599290 83 PAKLAALWFPEHQRATANMLATMSNPLGVLVANVLSPVLVKKGeDIPLMLGVYtipaGVVCLLSTICLWESVPPTPPSAG 162
Cdd:COG2223 114 GIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAF-GWRNAFLIL----GILLLVVAVLAWLFLRDPPAGAA 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462599290 163 AASSTSEK-FLDGLKLQLMWnKAYVILAVCLGGMIGISASFSALLEQILcasGHSSGFSGLCGALFITFGILGALALGPY 241
Cdd:COG2223 189 AAAKASLRdQLEALRDPRFW-LLSLLYFGTFGSFIGFSSWLPPYLVDQF---GLSAATAGLLAALFALLGALGRPLGGWL 264
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462599290 242 VDRTKhfteATKIGLCLFSLACVPFALVSQLQGQTLALAATCSLLGLF-GFSVGPVAMELAVecSFPVGE-GAATGMIFV 319
Cdd:COG2223 265 SDRIG----GRRVLLIVFALMALGLLLLALALGSLWLFLVLFLLLGLAlGGGNGAVFALVPD--IFPTKNaGAVYGLVGA 338
|
330
....*....|....*.
gi 2462599290 320 LGQAEGILIMLAMTAL 335
Cdd:COG2223 339 AGGLGGFLGPLLFGAL 354
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
3-327 |
4.89e-13 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 70.14 E-value: 4.89e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462599290 3 QINWLSLVYLVVSTPFGVAAIWILDSVGLRAATILGAWLNFAGSVLRMVPcmvvgtqNPFAFLMGGQSLCALAQSLVIFS 82
Cdd:pfam07690 33 EIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFA-------SSLWLLLVLRVLQGLGAGALFPA 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462599290 83 PAKLAALWFPEHQRATANMLATMSNPLGVLVANVLSPVLVkkgeDIPLMLGVYTIpAGVVCLLSTICLWESVPPTPPSAG 162
Cdd:pfam07690 106 ALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLA----SLFGWRAAFLI-LAILSLLAAVLLLLPRPPPESKRP 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462599290 163 AASSTSEKFLDGLKLQLMWNKAYVILAVCLGGMIGISAsFSALLEQILCASGHSSGFSGLCGALFITFGILGALALGPYV 242
Cdd:pfam07690 181 KPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFG-LLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLS 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462599290 243 DRTKHFTeATKIGLCLFSLACVPFALVSQLQGQTLALAAtCSLLGLFGFSVGPVAMELAVECSFPVGEGAATGMIFVLGQ 322
Cdd:pfam07690 260 DRLGRRR-RLLLALLLLILAALGLLLLSLTLSSLWLLLA-LLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGS 337
|
....*
gi 2462599290 323 AEGIL 327
Cdd:pfam07690 338 LGGAL 342
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
3-384 |
4.72e-12 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 67.20 E-value: 4.72e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462599290 3 QINWLSLVYLVVSTPFGVAAIWILDSVGLRAATILGAWLNFAGSVLrmvpCMVVGTqnpFAFLMGGQSLCALAQSLVIFS 82
Cdd:COG2271 46 QLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLL----FGFATS---FWQLLLLRFLLGLGEAGFFPA 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462599290 83 PAKLAALWFPEHQRATANMLATMSNPLGVLVANVLSPVLVKKGeDIPLMLGVYTIPAGVVCLLSTICLWesvpptppsag 162
Cdd:COG2271 119 ALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAF-GWRAAFLILGLPGLLLALLRFWLLA----------- 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462599290 163 aasstsekfldglklqlmwnkayVILAVCLGGMIGISASFSALLEQILcasGHSSGFSGLCGALFITFGILGALALGPYV 242
Cdd:COG2271 187 -----------------------LAYFLVYFALYGFLTWLPTYLVEVR---GLSLAQAGLLLSLPFLAGIVGSLLGGWLS 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462599290 243 DRtkhFTEATKIGLCLFSLACVPFALVSQLQGQTLALAATCSLLGLFGFSVGPVAMELAVECSFPVGEGAATGMIFVLGQ 322
Cdd:COG2271 241 DR---LGRRRKLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGF 317
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462599290 323 AEGILIMLAMTALTvrrsepslstcqqgeDPLDWTVSLLLMAGLCtFFSCILAVFFHTPYRR 384
Cdd:COG2271 318 LGGALGPLLVGYLL---------------DATGYQAAFLLLAALA-LLAALLALLLLRETRK 363
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
3-321 |
1.67e-11 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 66.05 E-value: 1.67e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462599290 3 QINWLSLVYLVVSTPFGVAAIWILDSVGLRAATILGAWLNFAGSVLRmvpcmvvGTQNPFAFLMGGQSLCALAQSLVIFS 82
Cdd:COG2807 54 QAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLR-------SLAPSVALLLAGTALIGAGIAVGNVL 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462599290 83 PAKLAALWFPEHqRATANMLATMSNPLGVLVANVLSPVLVKkGEDIPLMLGVYTIPAGVVCLLSTICLWESVPPTPPSAG 162
Cdd:COG2807 127 LPGLIKRWFPDR-VGLMTGLYTAAMGLGAALAAGLTVPLAA-ALGWRGALAVWALLALLALLLWLPLLRRRPAAAAAAPA 204
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462599290 163 AASSTSekfldglklqLMWNKAYVILAVCLGGMIGISASFSALLEQILCASGHSSGFSGLCGALFITFGILGALALGPYV 242
Cdd:COG2807 205 AASLRS----------LWRSPLAWLLTLFFGLQSLLYYAVVAWLPPILRDAGLSAATAGLLLSLFQLAGIPGSLLVPLLA 274
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462599290 243 DRTKHfteatKIGLCLFSLACVPFALVSQLQGQTLALAATCSLLGLFGFSVGPVAMELAVECSFPVGE-GAATGMIFVLG 321
Cdd:COG2807 275 DRLGD-----RRPLLLLLGLLGLAGLLGLLLAPGSLPWLWAVLLGLGQGGLFPLALTLIGLRARTPAEaAALSGMAQSVG 349
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
3-323 |
1.88e-11 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 65.38 E-value: 1.88e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462599290 3 QINWLSLVYLVVSTPFGVAAIWILDSVGLRAATILGAWLNFAGSVLrmvpCMVVGTqnpFAFLMGGQSLCALAQSLVIFS 82
Cdd:COG2814 46 QAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLL----CALAPS---LWLLLAARFLQGLGAGALFPA 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462599290 83 PAKLAALWFPEHQRATANMLATMSNPLGVLVANVLSPVLVKKGeDIPLMLGVytipAGVVCLLSTICLWESVPPTPPSAG 162
Cdd:COG2814 119 ALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLF-GWRWVFLV----NAVLALLALLLLLRLLPESRPAAR 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462599290 163 AASSTSEKFLDGLKLQLMwnkAYVILAVCLGGMIGISASFSALLEQILcasGHSSGFSGLCGALFITFGILGALALGPYV 242
Cdd:COG2814 194 ARLRGSLRELLRRPRLLL---LLLLAFLLGFGFFALFTYLPLYLQEVL---GLSASAAGLLLALFGLGGVLGALLAGRLA 267
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462599290 243 DRTKHFTeATKIGLCLFSLACVPFALVSQLqgqtLALAATCSLLGLFGFSVGPVAMELAVECSFPVGEGAATGMIFVLGQ 322
Cdd:COG2814 268 DRFGRRR-LLLIGLLLLALGLLLLALAGSL----WLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFF 342
|
.
gi 2462599290 323 A 323
Cdd:COG2814 343 L 343
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
94-298 |
5.71e-06 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 48.74 E-value: 5.71e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462599290 94 HQRATANMLATMSNPLGVLVANVLSPVLVKK-GEDIP----LMLGVYTIPAGVVCLLSTICLWESVPPTPPSAGaassts 168
Cdd:COG2211 143 EERTRLSSWRFAFAGLGGLLASVLPPPLVAAfGGDAAlgyrLTALIFAVLGLLAFLLTFFGTKERPVPEEEKVS------ 216
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462599290 169 ekFLDGLKlQLMWNKAYVIL-AVCLGGMIGISASFSALLEQILCASGHSSGFSGLCGALFITFGILGALALGPYVDRT-K 246
Cdd:COG2211 217 --LKESLK-ALLKNRPFLLLlLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFgK 293
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....
gi 2462599290 247 HFTeaTKIGLCLFSLACVPFALVSqlQGQTLALAATCSLLGLF--GFSVGPVAM 298
Cdd:COG2211 294 KKA--FIIGLLLAALGLLLLFFLG--PGNLWLLLVLAALAGIGlgAILVLPWAM 343
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
8-329 |
4.15e-05 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 45.64 E-value: 4.15e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462599290 8 SLVYLVVSTPFGvaaiWILDSVGLRAATILGawlnFAGSVLRMVPCMVVGTqnpFAFLMGGQSLCALAQSLVIFSPAKLA 87
Cdd:cd17325 41 ALAQLLFSPPAG----RLSDRFGRKRLLLLG----LLLLAVSTLLFAFATS---YWQLLLARFLQGLASAAVWPAAMALI 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462599290 88 ALWFPEHQRATANMLATMSNPLGVLVANVLSPVLVKKGeDIPLMLGVYTIPAGVVCLLSTICLWESVPPTPPSAGAASST 167
Cdd:cd17325 110 ADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADAL-GYRAPFLVCAALALLALVLALLLLPEPRPPPNKRAVSAARL 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462599290 168 SEKFLDGLKLQLMWnKAYVILAVCLGGMIGISASFSALLEQILCASghssgfSGLCGALFITFGILGALA---LGPYVDR 244
Cdd:cd17325 189 RSGLRLLLRDRRLL-ALFLAIFVLAFAFGALEPFLPLYAAELGGLS------PAQIGLLFGAQGLASALSqppAGKLSDR 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462599290 245 TKHFTEATkIGLCLFSLACVPFALVSQLqgqtLALAATCSLLGLFGFSVGPVAMELAVECSFPVGEGAATG---MIFVLG 321
Cdd:cd17325 262 IGRKPLIL-IGLLLSAVALLLLPLATSF----WLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGlfnTAFSLG 336
|
....*...
gi 2462599290 322 QAEGILIM 329
Cdd:cd17325 337 MVLGPLLG 344
|
|
| PHA03381 |
PHA03381 |
tegument protein VP22; Provisional |
388-493 |
4.54e-05 |
|
tegument protein VP22; Provisional
Pssm-ID: 177618 [Multi-domain] Cd Length: 290 Bit Score: 45.39 E-value: 4.54e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462599290 388 ESGEPPSTRNAVGGAD-SGPGVDRGGAGRAGVLGPSTATPECTARGAslEDPRGPGSPH---PACHRATPRAQGPAATdA 463
Cdd:PHA03381 83 RPADPRPSRRPHAQPEaSGPGPARGARGPAGSRGRGRRAESPSPRDP--PNPKGASAPRgrkSACADSAALLDAPAPA-A 159
|
90 100 110
....*....|....*....|....*....|
gi 2462599290 464 PSRPGRLAGRVQASRFidpAGSHSSFSSPW 493
Cdd:PHA03381 160 PKRQKTPAGLARKLHF---STAPTSPTAPW 186
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
90-329 |
5.52e-04 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 42.23 E-value: 5.52e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462599290 90 WFPEHQRATANMLATMSNPLGVLVANVLSPVLVKK-GEDIPLMLgvytipAGVVCLLSTICLWESVPPTPPSAGAASSTS 168
Cdd:cd17475 112 WFPPRERGLAMGIRQTGVPLGGALAAALLPPLALHyGWRAAFVV------AGLVSILAAVLFWLFYREPPAASAATESAS 185
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462599290 169 EKFldGLKLQLMWNKAYVILAVCLGGMIGISASFSALLEQILCASGH-SSGFSGLCGALFITFGILGALALGPYVDRtkH 247
Cdd:cd17475 186 TLL--RSLKEVLRNRDVWLIAIAGALLVAPQFALLTFLLLFLHDHLGlSVVAAGALLAVAQLGGALGRIGLGRVSDR--V 261
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462599290 248 FTEATKIGLCLFSLACV-PFALVSQLQGQT--LALAATCSLLGLFGFSVGPVAMELAVECSFPVGEGAATGMIFVLGQAe 324
Cdd:cd17475 262 FGGRRRPVLVITAAIAAaALLVLSLLSPGTplWLLVLLLILLGLFAIGWNGLYLTLVAESAGPEQAGTALGLANTINFI- 340
|
....*
gi 2462599290 325 GILIM 329
Cdd:cd17475 341 GIAIG 345
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
7-321 |
6.97e-04 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 41.76 E-value: 6.97e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462599290 7 LSLVYLVVSTPFGvaaiWILDSVGLRAATILGAWLNFAGsvlrmvpCMVVGTQNPFAFLMGGQSLCALAQSLVIFSPAKL 86
Cdd:COG0738 52 FFLGYLLASLPAG----RLIDRFGYKRGLLLGLLLMALG-------LLLFALAPSYPLLLLALFLLGLGLGLLDVAANPY 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462599290 87 AALWFPEHQRATANMLATMsNPLGVLVANVLSPVLVKKGEDIPLMLgVYTIPAGVVCLLSTICLWESVPPTPPSAGAASS 166
Cdd:COG0738 121 VAALGPETAASRLNLLHAF-FSLGALLGPLLGGLLILLGLSLSWHL-PYLILAVLLLLLALLFLRSKLPEIEEEEEEAAG 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462599290 167 TSEKFLDGLKLQLMWnkAYVILAVCLGGM-IGISASFSALLEQILcasGHSSGFSGLCGALFITFGILGALALGPYVDRT 245
Cdd:COG0738 199 SAASLKSLLKNPRLL--LGGLAIFLYVGAeGAIGDWLPLYLKDVL---GLSEATAALGLSLFWGGMTIGRFLGGFLLKRF 273
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2462599290 246 KhfteATKIGLCLFSLACVPFALVSQLQGQTLALAAtCSLLGlFGFSVG-PVAMELAVEcSFPVGEGAATGMIFVLG 321
Cdd:COG0738 274 G----PVRLLRLSALLAAVGLLLALLAPGPWLALIG-LALVG-LGLSLMfPTIFSLALD-GLGKRTAAAVSAVLIMG 343
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
8-296 |
1.07e-03 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 41.45 E-value: 1.07e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462599290 8 SLVYLVVSTPFGVAA------IWILDSVGLRAATILGAWLNFAGSVLRMVPCMVvgtqnpFAFLMGGQSlcalaqslVIF 81
Cdd:cd06173 44 FLPFLLFSPFAGVLAdrfdrrRLLILADLLRALLAAVLALLALLGSLSLWLLLV------LAFLLGIAS--------AFF 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462599290 82 SPAKLAAL--WFPEHQRATANMLATMSNPLGVLVANVLSPVLVKKGEDIPLMLGVytipaGVVCLLSTICLWESVPPTPP 159
Cdd:cd06173 110 GPARQALLpeLVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFAIN-----ALSFLLSALLLLFIRRPPPA 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462599290 160 SAGAASSTSEKFLDGLKLQLMWNKAYVILAVCLGGMIGISASFSALLeqILCASGHSSGFSGLCGALFITFGI---LGAL 236
Cdd:cd06173 185 APGESSSLLLRDLREGLRYLRRSPLLRLLLLALALFALLGGALTVLL--PLLAKEVLGGGAAGYGLLLAAFGVgalLGAL 262
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462599290 237 ALGPYVDRTKHFTeATKIGLCLFSLACVPFALVSQLqgqTLALAAtcslLGLFGFSVGPV 296
Cdd:cd06173 263 LLGRLSKRRRRGR-LLLIGALLLGLALLVLGLSPSL---WLLLAA----LFLLGLAGGLF 314
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
50-316 |
1.45e-03 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 41.00 E-value: 1.45e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462599290 50 MVPCMVVGTQNPFAFLMGGQSLCALAQSLVIFSPAKLAALWFPEHQRATANMLATMSNPLGVLVANVLSPVLvkkGEdip 129
Cdd:cd17324 75 ILGNLLAALAPSFALLLLARALAGLAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLL---GQ--- 148
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462599290 130 lMLG--VYTIPAGVVCLLSTICLWESVPPTPPSAGAASSTSEKFLDGLKLQLMWnKAYVILAVCLGGMIGISASFSALLE 207
Cdd:cd17324 149 -LLGwrAAFLAIAVLALLAALLLWRLLPSLPPKKPGSLGLLSSLLLLLRNPRLR-LAYLITFLLFGGFFALYTYLAPFLT 226
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462599290 208 QIlcaSGHSSGFSGLCGALFITFGILGALALGPYVDRTKHFTEATKIGLCLFSLACVPFALvsqlqGQTLALAATCSLLG 287
Cdd:cd17324 227 DV---PGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRALLIALLLLAAALLLLTLLG-----PSPLLLLVGLVLWG 298
|
250 260
....*....|....*....|....*....
gi 2462599290 288 LFGFSVGPVAMELAVECSfPVGEGAATGM 316
Cdd:cd17324 299 LGFFAAHSALQTRVLRLA-PEARGLASSL 326
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
82-378 |
1.55e-03 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 40.68 E-value: 1.55e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462599290 82 SPAKLAALwFPEHQRATANMLATMSNPLGVLVANVLSPVLVKKGEDIPLMLGVyTIPAGVVCLLstICLWesVPPTPPSA 161
Cdd:cd17328 108 APTIIADL-FPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAQATGGWRWAFRV-TGVLGVLLAI--LLLL--FVREPPRG 181
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462599290 162 GAA-----SSTSEKFLDGLKlQLMWNKAYVIL---AVCLGGMIGISASFSALLEQ-ILCASGHSSGFSGLC-GALFITFG 231
Cdd:cd17328 182 AAEggvmaKSTATSFLADLK-ALAKNPSFILStlgFTAVSFVTGALAFWAPTFFLrAFGVGDLSSADVGLIfGAITCIAG 260
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462599290 232 ILGALALGPYVDRTKHFTEATKIGLCLFS-LACVPFALVSQLQGQT-LALAATCSLLGLFGFSV--GPVAMELaVECSFP 307
Cdd:cd17328 261 VLGVLLGGILADRLRRKTPRADPLVCAVGlLAAAPFLFLALVLALSnLLLAWVLLFLGEFLLSLnwAPVFAIL-LYVVIP 339
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2462599290 308 VGEGAATGMIFV----LGQAEGILIMLAMTALTVRRSEPSLSTCQQgedpldWTVSLLlmagLCTFFSCILAVFF 378
Cdd:cd17328 340 TRRSTASAIQILlshlLGDAGSPYLIGLISDLLRQNKDSPLAEAAS------LQYALL----LCSFVLVLGGFFF 404
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
53-329 |
2.95e-03 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 39.86 E-value: 2.95e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462599290 53 CMVVGTQNPFAFLMGGQSLCALAQSLVIFSPAKLAALWFPEHQRATANMLATMSNPLGVLVANVLSPVLVKKGEDIPLML 132
Cdd:cd17474 78 GLLCGLSDSFALLLAGRALQGIGAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLLAAISWRYPFFL 157
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462599290 133 GVYTIPAGVVCLLstICLWESVPPTPPSAGAASSTSEKFLDGLKLQLMwnkaYVILAVCLGGMIGISASFSALLEQILCA 212
Cdd:cd17474 158 LAALIPVAFLAIL--FLLPEPKEKAKSSSATKLRDLKKALRGRGLLTF----LVSAFLYFFLYFAFLTYLPFLLELLYGI 231
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462599290 213 SGHSSGFSgLCGALFITfgILGALALGPYVDRTKHFTEATKIGLCLFSLAcvpFALVSQLQGQTLALAATcSLLGLFGFS 292
Cdd:cd17474 232 SPIIIGLL-FAGWSVLL--ALGSLFVGRLLKKRFGARRILVIGLLLYALS---LLLLGFVPSLALLLIAI-VLFGLGLGL 304
|
250 260 270 280
....*....|....*....|....*....|....*....|
gi 2462599290 293 VGPVAMELAVECSFPVGEGAAT---GMIFVLGQAEGILIM 329
Cdd:cd17474 305 NLPLLTTLVTELAPEEERGTASslyNFVRFLGQAVGPLLF 344
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
6-322 |
3.53e-03 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 39.56 E-value: 3.53e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462599290 6 WLSLVYLVVSTPFGVAAI---WILDSVGLRAATILGAWLNFAGSVLrmvpcmVVGTQNPFAFLMGGQSLCALAQSLVIFS 82
Cdd:cd17355 39 VISLAFTVGLLAFGLAQPfvgRLLDRFGPRRVMLLGLLLLAAGLVL------LALATSLWQLYLLWGLLGGGGAGTLAAV 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462599290 83 PAKLAALWFPEHQRATANMLATMSNPLGVLVanvLSPVLVKKGEDIP--LMLGVYTIPAGVVCLLSTICLWESVPPTPPS 160
Cdd:cd17355 113 AFATVAAWWFERRRGLALGILTAGGGLGSLV---FLPLGAALIEAFGwrTALLVLALLALLVLVPVLLLLRRRPADLALR 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462599290 161 AGAASSTSEkfLDGLKLQLMWNKAYVIL----AVCLGGMIGISASFSALLeqilCASGHSSGFSGLCGALFITFGILGAL 236
Cdd:cd17355 190 AYDDASPAS--PGSTLKEALRSASFWLLalafFLCGFAVVGLIVHLVPYL----ADRGISPAAAAVALALIGLFNIVGRL 263
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462599290 237 ALGPYVDRtkhfTEATKIGLCLFSLACVPFALVSQLQGQTLALAATCSLLGLFGFSVGPVAMELAVECSFPVGEGAATGM 316
Cdd:cd17355 264 LSGWLGDR----YSPRRLLAASYALRALGLALLLLLPFPPLALLLFAALFGLGWGATVPLTAALAARYFGARSYGTLFGL 339
|
....*.
gi 2462599290 317 IFVLGQ 322
Cdd:cd17355 340 VFAPHQ 345
|
|
| MATE_rft1 |
cd13130 |
Rft1-like subfamily of the multidrug and toxic compound extrusion family (MATE); This ... |
257-382 |
9.79e-03 |
|
Rft1-like subfamily of the multidrug and toxic compound extrusion family (MATE); This eukaryotic family may function as a transporter, shuttling phospholipids, lipopolysaccharides or oligosaccharides from cytoplasmic to the lumenal side of the endoplasmic reticulum. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance.
Pssm-ID: 240535 Cd Length: 441 Bit Score: 38.48 E-value: 9.79e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462599290 257 CLFSLACVPFALVSQ--------LQGQTLALAATCslLGLFGFSVGPVAMELAvecsfpvgegaatGMIFVLGQ-AEGIL 327
Cdd:cd13130 131 CILELLSEPLYILSQnllkfrlrAIVETAATLVRC--LTTFILIVLGTGKEPK-------------VLVFALGQlAYGVC 195
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2462599290 328 IMLAM--TALTVRRSEPSLSTCQQGEDPLDWTVSLLLMAGLCTFFSC----------ILAVFFHTPY 382
Cdd:cd13130 196 LFFGYwyYFLQCFVSKKSSLFPLRNSNLMFFDKPTLRMCGLFTIQSFfkhlltegdkIVLVWFDTPY 262
|
|
| |
