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Conserved domains on  [gi|2462604283|ref|XP_054209418|]
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cyclin-J-like protein isoform X3 [Homo sapiens]

Protein Classification

cyclin J family protein( domain architecture ID 15751054)

cyclin J family protein similar to human cyclin-J-like protein (CCNJL) that may act as a potential diagnostic biomarker of colon cancer

CATH:  1.10.472.10
Gene Ontology:  GO:0000079|GO:0019901
PubMed:  30185601
SCOP:  4001102

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CYCLIN_SF super family cl40454
Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in ...
 33-94 3.25e-24

Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in cell-cycle and transcriptional control. It is about 100 amino acids in length, composed of five helices, and is present in cyclins, transcription initiation factor IIB (TFIIB), and retinoblastoma tumour suppressor protein (Rb). Cyclins consist of 8 classes of cell cycle regulators that function as regulatory subunits of cyclin-dependent kinases (CDKs), which are serine/threonine kinases. The catalytic activities of CDKs are modulated not only by their interactions with cyclins but also by CDK inhibitors (CKIs). CDKs, cyclins and CKIs play key roles in transcription, epigenetic regulation, metabolism, stem cell self-renewal, neuronal functions, and spermatogenesis. TFIIB is a transcription factor that binds the TATA box. Members in this superfamily contain one or two copies of the cyclin box.


The actual alignment was detected with superfamily member cd20528:

Pssm-ID: 477360 [Multi-domain]  Cd Length: 103  Bit Score: 93.82  E-value: 3.25e-24
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462604283  33 SPLLKSRRFFVDILTLLSSHCQLCPAARHLAVYLLDHFMDRYNVTTSkQLYTVAVSCLLLAN 94
Cdd:cd20528     1 SPQLHLRRYLVDWLAVVSERLKLSDTTLHLAVYLLDRFMDRYDISED-QLHLVALTCLLLAA 61
CYCLIN_CCNJ-like_rpt2 cd20529
second cyclin box found in cyclin-J (CCNJ) family; The CCNJ family includes two cyclins, CCNJ ...
 83-145 2.55e-16

second cyclin box found in cyclin-J (CCNJ) family; The CCNJ family includes two cyclins, CCNJ and CCNJ-like. CCNJ may regulate the cell cycle or transcription. Members of this family contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


:

Pssm-ID: 410232 [Multi-domain]  Cd Length: 101  Bit Score: 72.78  E-value: 2.55e-16
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462604283  83 YTVAVSCLLLANHIFYKFQPSVVAAACVGASRICLQLSPYWTRDLQRISSYSLEHLSTCIEIL 145
Cdd:cd20529    39 YADFFLDLSLQDYAFLNYKPSLLAAACIAAARKALGLSPTWPEELEKLTGYSEDELEPCVELL 101
 
Name Accession Description Interval E-value
CYCLIN_CCNJ-like_rpt1 cd20528
first cyclin box found in cyclin-J (CCNJ) family; The CCNJ family includes two cyclins, CCNJ ...
 33-94 3.25e-24

first cyclin box found in cyclin-J (CCNJ) family; The CCNJ family includes two cyclins, CCNJ and CCNJ-like. CCNJ may regulate the cell cycle or transcription. Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410231 [Multi-domain]  Cd Length: 103  Bit Score: 93.82  E-value: 3.25e-24
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462604283  33 SPLLKSRRFFVDILTLLSSHCQLCPAARHLAVYLLDHFMDRYNVTTSkQLYTVAVSCLLLAN 94
Cdd:cd20528     1 SPQLHLRRYLVDWLAVVSERLKLSDTTLHLAVYLLDRFMDRYDISED-QLHLVALTCLLLAA 61
CYCLIN_CCNJ-like_rpt2 cd20529
second cyclin box found in cyclin-J (CCNJ) family; The CCNJ family includes two cyclins, CCNJ ...
 83-145 2.55e-16

second cyclin box found in cyclin-J (CCNJ) family; The CCNJ family includes two cyclins, CCNJ and CCNJ-like. CCNJ may regulate the cell cycle or transcription. Members of this family contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410232 [Multi-domain]  Cd Length: 101  Bit Score: 72.78  E-value: 2.55e-16
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462604283  83 YTVAVSCLLLANHIFYKFQPSVVAAACVGASRICLQLSPYWTRDLQRISSYSLEHLSTCIEIL 145
Cdd:cd20529    39 YADFFLDLSLQDYAFLNYKPSLLAAACIAAARKALGLSPTWPEELEKLTGYSEDELEPCVELL 101
Cyclin_C pfam02984
Cyclin, C-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a ...
 67-146 6.68e-09

Cyclin, C-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the C-terminal domain.


Pssm-ID: 397230  Cd Length: 119  Bit Score: 53.01  E-value: 6.68e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462604283  67 LDHFMDRYNVTTSKQLYTVAvSCLL---LANHIFYKFQPSVVAAACVGASRICLQlSPYWTRDLQRISSYSLEHLSTCIE 143
Cdd:pfam02984   7 LRRFSKAADYLHDLELRTLA-KYLLeltLLDYDFLKYPPSLIAAAAVYLARKTLN-SPEWTETLEHYTGYSEEDLKPCVK 84


                  ...
gi 2462604283 144 ILL 146
Cdd:pfam02984  85 LLL 87
CYCLIN smart00385
domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and ...
 46-146 3.76e-06

domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and TFIIB (twice) and Retinoblastoma (once). A protein recognition domain functioning in cell-cycle and transcription control.


Pssm-ID: 214641 [Multi-domain]  Cd Length: 83  Bit Score: 44.12  E-value: 3.76e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462604283   46 LTLLSSHCQLCPAARHLAVYLLDHFMDRYNVTtskqlytvavsclllanhifyKFQPSVVAAACVGASRICLQLSPyWTR 125
Cdd:smart00385   3 LRRVCKALNLDPETLNLAVNLLDRFLSDYKFL---------------------KYSPSLIAAAALYLASKTEETPP-WTK 60

                           90       100
                   ....*....|....*....|..
gi 2462604283  126 DLQRISSY-SLEHLSTCIEILL 146
Cdd:smart00385  61 ELVHYTGYfTEEEILRMERLLL 82
Cyclin_N pfam00134
Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a ...
 14-93 7.33e-06

Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the N-terminal domain.


Pssm-ID: 459686 [Multi-domain]  Cd Length: 127  Bit Score: 44.43  E-value: 7.33e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462604283  14 DVHCTLREKELKLPtfRAHSPLLKS-------RRFFVDILTLLSSHCQLCPAARHLAVYLLDHFMDRYNVTTSKqLYTVA 86
Cdd:pfam00134   1 DIFQYLRELELKYL--PKPDYMDQQpdinpkmRAILIDWLVEVHEKFKLLPETLYLAVNYLDRFLSKKSVPKNK-LQLVG 77


                  ....*..
gi 2462604283  87 VSCLLLA 93
Cdd:pfam00134  78 VTCLFIA 84
 
Name Accession Description Interval E-value
CYCLIN_CCNJ-like_rpt1 cd20528
first cyclin box found in cyclin-J (CCNJ) family; The CCNJ family includes two cyclins, CCNJ ...
 33-94 3.25e-24

first cyclin box found in cyclin-J (CCNJ) family; The CCNJ family includes two cyclins, CCNJ and CCNJ-like. CCNJ may regulate the cell cycle or transcription. Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410231 [Multi-domain]  Cd Length: 103  Bit Score: 93.82  E-value: 3.25e-24
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462604283  33 SPLLKSRRFFVDILTLLSSHCQLCPAARHLAVYLLDHFMDRYNVTTSkQLYTVAVSCLLLAN 94
Cdd:cd20528     1 SPQLHLRRYLVDWLAVVSERLKLSDTTLHLAVYLLDRFMDRYDISED-QLHLVALTCLLLAA 61
CYCLIN_CCNJ-like_rpt2 cd20529
second cyclin box found in cyclin-J (CCNJ) family; The CCNJ family includes two cyclins, CCNJ ...
 83-145 2.55e-16

second cyclin box found in cyclin-J (CCNJ) family; The CCNJ family includes two cyclins, CCNJ and CCNJ-like. CCNJ may regulate the cell cycle or transcription. Members of this family contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410232 [Multi-domain]  Cd Length: 101  Bit Score: 72.78  E-value: 2.55e-16
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462604283  83 YTVAVSCLLLANHIFYKFQPSVVAAACVGASRICLQLSPYWTRDLQRISSYSLEHLSTCIEIL 145
Cdd:cd20529    39 YADFFLDLSLQDYAFLNYKPSLLAAACIAAARKALGLSPTWPEELEKLTGYSEDELEPCVELL 101
Cyclin_C pfam02984
Cyclin, C-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a ...
 67-146 6.68e-09

Cyclin, C-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the C-terminal domain.


Pssm-ID: 397230  Cd Length: 119  Bit Score: 53.01  E-value: 6.68e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462604283  67 LDHFMDRYNVTTSKQLYTVAvSCLL---LANHIFYKFQPSVVAAACVGASRICLQlSPYWTRDLQRISSYSLEHLSTCIE 143
Cdd:pfam02984   7 LRRFSKAADYLHDLELRTLA-KYLLeltLLDYDFLKYPPSLIAAAAVYLARKTLN-SPEWTETLEHYTGYSEEDLKPCVK 84


                  ...
gi 2462604283 144 ILL 146
Cdd:pfam02984  85 LLL 87
CYCLIN_CCNO-like_rpt2 cd20537
second cyclin box found in cyclin-O (CCNO) and similar proteins; This subfamily is composed of ...
 46-151 1.33e-07

second cyclin box found in cyclin-O (CCNO) and similar proteins; This subfamily is composed of CCNO and similar proteins including Schizosaccharomyces pombe meiosis-specific cyclin rem1, Drosophila melanogaster G2/mitotic-specific cyclin-A (CCNA), and Candida albicans G1/S-specific cyclin CCN1, among others. Rem1 is required for pre-meiotic DNA synthesis and S phase progression. CCNA is essential for the control of the cell cycle at the G2/M (mitosis) transition. CCN1 is essential for the control of the cell cycle at the G1/S (start) transition and for maintenance of filamentous growth. CCNO is specifically required for generation of multiciliated cells, possibly by promoting a cell cycle state compatible with centriole amplification and maturation. It is involved in the activation of cyclin-dependent kinase 2. Members of this subfamily contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410240 [Multi-domain]  Cd Length: 91  Bit Score: 48.46  E-value: 1.33e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462604283  46 LTLLSSHCQLCPAARHLAVYLLDHfmdrynvttskqlytvavsCLLlaNHIFYKFQPSVVAAACVGASRICLQLSPYWTR 125
Cdd:cd20537     7 LRRYLSLLGLDEKVRHLARYLLEL-------------------SLL--DYEFLKYRPSLIAAAALYLARKILGEPPPSPQ 65

                          90       100
                  ....*....|....*....|....*.
gi 2462604283 126 DLQRISSYSLEHLSTCIEILLVVYDN 151
Cdd:cd20537    66 LLQLVTGYSENDLQECAKELLELLAQ 91
CYCLIN smart00385
domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and ...
 46-146 3.76e-06

domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and TFIIB (twice) and Retinoblastoma (once). A protein recognition domain functioning in cell-cycle and transcription control.


Pssm-ID: 214641 [Multi-domain]  Cd Length: 83  Bit Score: 44.12  E-value: 3.76e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462604283   46 LTLLSSHCQLCPAARHLAVYLLDHFMDRYNVTtskqlytvavsclllanhifyKFQPSVVAAACVGASRICLQLSPyWTR 125
Cdd:smart00385   3 LRRVCKALNLDPETLNLAVNLLDRFLSDYKFL---------------------KYSPSLIAAAALYLASKTEETPP-WTK 60

                           90       100
                   ....*....|....*....|..
gi 2462604283  126 DLQRISSY-SLEHLSTCIEILL 146
Cdd:smart00385  61 ELVHYTGYfTEEEILRMERLLL 82
Cyclin_N pfam00134
Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a ...
 14-93 7.33e-06

Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the N-terminal domain.


Pssm-ID: 459686 [Multi-domain]  Cd Length: 127  Bit Score: 44.43  E-value: 7.33e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462604283  14 DVHCTLREKELKLPtfRAHSPLLKS-------RRFFVDILTLLSSHCQLCPAARHLAVYLLDHFMDRYNVTTSKqLYTVA 86
Cdd:pfam00134   1 DIFQYLRELELKYL--PKPDYMDQQpdinpkmRAILIDWLVEVHEKFKLLPETLYLAVNYLDRFLSKKSVPKNK-LQLVG 77


                  ....*..
gi 2462604283  87 VSCLLLA 93
Cdd:pfam00134  78 VTCLFIA 84
CYCLIN_CCNA_rpt2 cd20505
second cyclin box found in cyclin-A (CCNA) family; The CCNA family includes two A-type cyclins, ...
 51-151 8.47e-06

second cyclin box found in cyclin-A (CCNA) family; The CCNA family includes two A-type cyclins, CCNA1 and CCNA2. CCNA1 may primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells. CCNA2 controls both the G1/S and the G2/M transition phases of the cell cycle. Members in this family contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410209 [Multi-domain]  Cd Length: 110  Bit Score: 43.82  E-value: 8.47e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462604283  51 SHCQLCPAARHLAVYLLDhfmdrynvttskqlytvaVSclLLANHIFYKFQPSVVAAACVGASRICLQlSPYWTRDLQRI 130
Cdd:cd20505    12 KHSNADEKTKSLAMYLCE------------------LS--LIDADPYLKYLPSVIAAAAVCLANHTLG-NEVWPQKLARS 70

                          90       100
                  ....*....|....*....|.
gi 2462604283 131 SSYSLEHLSTCIEILLVVYDN 151
Cdd:cd20505    71 TGYSLEDLLPCLRDLHRTFLN 91
CYCLIN_AtCycB-like_rpt2 cd20511
second cyclin box found in Arabidopsis thaliana B-type cyclins (CycBs) and similar proteins; ...
 90-151 3.10e-05

second cyclin box found in Arabidopsis thaliana B-type cyclins (CycBs) and similar proteins; Plant B-type cyclins (CycBs) correspond to a group of G2/mitotic-specific cyclins that are functionally linked to S- and M-phases of the mitotic cycle, which predicts their involvement also in meiosis. CycBs associate with their partner cyclin-dependent kinases (CDKs) to trigger the kinase activity. They contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410215  Cd Length: 117  Bit Score: 42.29  E-value: 3.10e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462604283  90 LLLANHIFYKFQPSVVAAACVGASRICLQLSPYWTRDLQRISSYSLEHLSTCIEILLVVYDN 151
Cdd:cd20511    30 LGLVEYEMLKYSPSMLAASAVYTARCTLNKTPEWTSTLEFHTGYSESQLMECARLMVRLHSK 91
CYCLIN_AtCycA-like_rpt2 cd20506
second cyclin box found in Arabidopsis thaliana A-type cyclins (CycAs) and similar proteins; ...
 88-145 7.97e-05

second cyclin box found in Arabidopsis thaliana A-type cyclins (CycAs) and similar proteins; Plant A-type cyclins (CycAs) correspond to a group of G2/mitotic-specific cyclins that are functionally linked to S- and M-phases of the mitotic cycle, which predicts their involvement also in meiosis. CycAs associate with their partner cyclin-dependent kinases (CDKs) to trigger the kinase activity. They contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410210  Cd Length: 111  Bit Score: 41.08  E-value: 7.97e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2462604283  88 SCLLLANHIFYKFQPSVVAAACVGASRICLQLSPyWTRDLQRISSYSLEHLSTCIEIL 145
Cdd:cd20506    31 AELSLLDYEFLKYLPSLIAASAVFLARHTLNPHP-WNPTLEHYTGYKAADLKPCVQAL 87
CYCLIN_SF cd00043
Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in ...
 43-144 6.53e-04

Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in cell-cycle and transcriptional control. It is about 100 amino acids in length, composed of five helices, and is present in cyclins, transcription initiation factor IIB (TFIIB), and retinoblastoma tumour suppressor protein (Rb). Cyclins consist of 8 classes of cell cycle regulators that function as regulatory subunits of cyclin-dependent kinases (CDKs), which are serine/threonine kinases. The catalytic activities of CDKs are modulated not only by their interactions with cyclins but also by CDK inhibitors (CKIs). CDKs, cyclins and CKIs play key roles in transcription, epigenetic regulation, metabolism, stem cell self-renewal, neuronal functions, and spermatogenesis. TFIIB is a transcription factor that binds the TATA box. Members in this superfamily contain one or two copies of the cyclin box.


Pssm-ID: 410207 [Multi-domain]  Cd Length: 82  Bit Score: 37.78  E-value: 6.53e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462604283  43 VDILTLLSSHCQLCPAARHLAVYLLDHFMDRynvttskqlytvavsclllanHIFYKFQPSVVAAACV-GASRICLQlsP 121
Cdd:cd00043     3 VDFIRRLCSKLGLPEEVLELAIELLDRFLSK---------------------GLLLGRSPELIAAACLyLACKLEEL--P 59

                          90       100
                  ....*....|....*....|...
gi 2462604283 122 YWTRDLQRISSYSLEHLSTCIEI 144
Cdd:cd00043    60 RTLKEIAKVSGVSEKELRKAEKE 82
CYCLIN_CNTD2 cd20542
cyclin box found in Cyclin N-terminal domain-containing protein 2 (CNTD2) and similar proteins; ...
 39-104 9.33e-04

cyclin box found in Cyclin N-terminal domain-containing protein 2 (CNTD2) and similar proteins; CNTD2 is an atypical cyclin upregulated in human cancer tissues. It promotes cell proliferation and migration, as well as increases tumor growth in vivo. It can function as a prognostic factor and drug target. CNTD2 contains one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410245 [Multi-domain]  Cd Length: 96  Bit Score: 37.69  E-value: 9.33e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2462604283  39 RRFFVDILTLLSSHCQLCPAARHLAVYLLDHFMDRYNVTTSK-QLytVAVSCLLLANHIFYKFQPSV 104
Cdd:cd20542     1 RAILVDWLVQVQEHLELSTQTLHLAVALLDRYLSRQKISLSLlQL--LGITCLFIACKFEERFPPEV 65
CYCLIN_CLBs_yeast_rpt1 cd20568
first cyclin box found in yeast B-type cyclins; This subfamily includes Saccharomyces ...
 19-93 1.05e-03

first cyclin box found in yeast B-type cyclins; This subfamily includes Saccharomyces cerevisiae G2/mitotic-specific cyclins 1-4 (ScCLB1-4), S-phase entry cyclins 5-6 (ScCLB5-6), and Schizosaccharomyces pombe G2/mitotic-specific cyclins, cig1, cig2 and cdc13. ScCLB1-4 are essential for the control of the cell cycle at the G2/M (mitosis) transition. They interact with the CDC2 protein kinase to form maturation promoting factor (MPF). ScCLB5-6 interact with CDC28 and are involved in DNA replication in Saccharomyces cerevisiae. ScCLB5 is required for efficient progression through S phase and possibly for the normal progression through meiosis. ScCLB6 is involved in G1/S and or S phase progression. Cig1 is required for efficient passage of the G1/S transition. Cig2 and cdc13 are essential for the control of the cell cycle at the G2/M and G1/S (mitosis) transitions. They interact with the cdc2 protein kinase to form MPF. Members in this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410271  Cd Length: 134  Bit Score: 38.43  E-value: 1.05e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462604283  19 LREKELKL---PTFRAHSPLL--KSRRFFVDILTLLSSHCQLCPAARHLAVYLLDHFMDRYNVTTSK-QLytVAVSCLLL 92
Cdd:cd20568    16 LRELELKTlpnPNYMDDQKELrwKMRGILVDWLVEVHEKFRLLPETLFLAVNIIDRFLSKRVVSLNKlQL--VGISALFI 93


                  .
gi 2462604283  93 A 93
Cdd:cd20568    94 A 94
CYCLIN_CCNB1-like_rpt1 cd20507
first cyclin box found in cyclin-B1 (CCNB1)-like family; The CCNB1-like family includes two ...
 12-93 3.84e-03

first cyclin box found in cyclin-B1 (CCNB1)-like family; The CCNB1-like family includes two B-type cyclins, CCNB1 and CCNB2, both of which are essential for the control of the cell cycle at the G2/M (mitosis) transition. Members in this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410211 [Multi-domain]  Cd Length: 130  Bit Score: 36.74  E-value: 3.84e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462604283  12 ASDVHCTLREKELKL---PTFRAHSPLL--KSRRFFVDILTLLSSHCQLCPAARHLAVYLLDHFMDRYNVtTSKQLYTVA 86
Cdd:cd20507     5 VKDIYKYLRQLEKKYaidPDYLSGQPEIteRMRAILVDWLVEVHLKFKLLPETLYLTVNIIDRYLSKKQV-PRKKLQLVG 83


                  ....*..
gi 2462604283  87 VSCLLLA 93
Cdd:cd20507    84 VTALLIA 90
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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