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Conserved domains on  [gi|2462612175|ref|XP_054213135|]
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zona pellucida-binding protein 1 isoform X5 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Sp38 super family cl20050
Zona-pellucida-binding protein (Sp38); This family contains a number of zona-pellucida-binding ...
 126-271 1.98e-61

Zona-pellucida-binding protein (Sp38); This family contains a number of zona-pellucida-binding proteins that seem to be restricted to mammals. These are sperm proteins that bind to the 90-kDa family of zona pellucida glycoproteins in a calcium-dependent manner. These represent some of the specific molecules that mediate the first steps of gamete interaction, allowing fertilization to occur.


The actual alignment was detected with superfamily member pfam07354:

Pssm-ID: 336682  Cd Length: 177  Bit Score: 193.55  E-value: 1.98e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462612175 126 YHAAPCNSIYNISFEKKLLQILSKLLLDLSCEISLLKSECHRVKMQRAGLQNELFFAFSVSSLDT--EKGPKRCTDHNCE 203
Cdd:pfam07354   1 FTAAPCNSRYNDSFFRELKKILSKLISDLSCEVSLPSYECHSVKMPRRGLQSELFFTFQVNPFAPgwKDLCNRSLDCEDT 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2462612175 204 PYKRLFKAKNLIERFFNQQVEILGRRAEQLPQIYYIEGTLQMVWINRCFPGYGMNVQQHPKCPECCVV 271
Cdd:pfam07354  81 TNHRLLKAKDRIERFFRSQVYILKHQFETLPEIHYVEGSLQVVWIDRCRPGFGKNEILHPNCAECCVV 148
 
Name Accession Description Interval E-value
Sp38 pfam07354
Zona-pellucida-binding protein (Sp38); This family contains a number of zona-pellucida-binding ...
 126-271 1.98e-61

Zona-pellucida-binding protein (Sp38); This family contains a number of zona-pellucida-binding proteins that seem to be restricted to mammals. These are sperm proteins that bind to the 90-kDa family of zona pellucida glycoproteins in a calcium-dependent manner. These represent some of the specific molecules that mediate the first steps of gamete interaction, allowing fertilization to occur.


Pssm-ID: 336682  Cd Length: 177  Bit Score: 193.55  E-value: 1.98e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462612175 126 YHAAPCNSIYNISFEKKLLQILSKLLLDLSCEISLLKSECHRVKMQRAGLQNELFFAFSVSSLDT--EKGPKRCTDHNCE 203
Cdd:pfam07354   1 FTAAPCNSRYNDSFFRELKKILSKLISDLSCEVSLPSYECHSVKMPRRGLQSELFFTFQVNPFAPgwKDLCNRSLDCEDT 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2462612175 204 PYKRLFKAKNLIERFFNQQVEILGRRAEQLPQIYYIEGTLQMVWINRCFPGYGMNVQQHPKCPECCVV 271
Cdd:pfam07354  81 TNHRLLKAKDRIERFFRSQVYILKHQFETLPEIHYVEGSLQVVWIDRCRPGFGKNEILHPNCAECCVV 148
 
Name Accession Description Interval E-value
Sp38 pfam07354
Zona-pellucida-binding protein (Sp38); This family contains a number of zona-pellucida-binding ...
 126-271 1.98e-61

Zona-pellucida-binding protein (Sp38); This family contains a number of zona-pellucida-binding proteins that seem to be restricted to mammals. These are sperm proteins that bind to the 90-kDa family of zona pellucida glycoproteins in a calcium-dependent manner. These represent some of the specific molecules that mediate the first steps of gamete interaction, allowing fertilization to occur.


Pssm-ID: 336682  Cd Length: 177  Bit Score: 193.55  E-value: 1.98e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462612175 126 YHAAPCNSIYNISFEKKLLQILSKLLLDLSCEISLLKSECHRVKMQRAGLQNELFFAFSVSSLDT--EKGPKRCTDHNCE 203
Cdd:pfam07354   1 FTAAPCNSRYNDSFFRELKKILSKLISDLSCEVSLPSYECHSVKMPRRGLQSELFFTFQVNPFAPgwKDLCNRSLDCEDT 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2462612175 204 PYKRLFKAKNLIERFFNQQVEILGRRAEQLPQIYYIEGTLQMVWINRCFPGYGMNVQQHPKCPECCVV 271
Cdd:pfam07354  81 TNHRLLKAKDRIERFFRSQVYILKHQFETLPEIHYVEGSLQVVWIDRCRPGFGKNEILHPNCAECCVV 148
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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