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Conserved domains on  [gi|2462615790|ref|XP_054214829|]
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solute carrier family 13 member 1 isoform X4 [Homo sapiens]

Protein Classification

SLC13 family permease( domain architecture ID 11422084)

SLC13 (solute carrier 13) family permease is a sodium-coupled symporter that facilitates the transport across biological membranes of various ions including sulfate or Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate; may function as a regulator

Gene Ontology:  GO:0016020|GO:0015293|GO:0006811|GO:0055085|GO:0022857
PubMed:  23177988|24114175|23506872
SCOP:  4006109
TCDB:  2.A.47

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CitT COG0471
Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism];
26-564 1.54e-74

Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism];


:

Pssm-ID: 440239 [Multi-domain]  Cd Length: 369  Bit Score: 241.98  E-value: 1.54e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462615790  26 IGVICLATSIEKWNLHKRIALKMVMMVGVNPAWLTLGFMSSTAFLSMWLSNTSTAAMVMPIAEAVVQQiinaeaeveatq 105
Cdd:COG0471     1 LGGFVLAAALEKTGLGRRIALLLLKRFGGSPLRLLLGLMLATALLSAFISNTARAAMMLPIALSIAAA------------ 68

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462615790 106 mtyfngstnhgleidesvngheinerkektkpvpgynndtgkisskvelekeeeesnqqrvftgswvrkrmklllaytle 185
Cdd:COG0471       --------------------------------------------------------------------------------

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462615790 186 shllnktltfglvipqvkpfqdvplsknsgmrtkYRTKKGHVTRKLTCLCIAYSSTIGGLTTITGTSTNLIFAEYFNTRY 265
Cdd:COG0471    69 ----------------------------------LGSEKRSKFGSALLLPIAFAASIGGMGTLIGTPPNLIAAGLLEEAT 114

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462615790 266 PdcRCLNFGSWFTFSFPAALIILLLSWIWLQWLFlgfnfkemfkcgKTKTVQQKACAEVIKQEYQKLGPIRYQEIVTLVL 345
Cdd:COG0471   115 G--IPISFFEWMLVGLPVALVGLLLLWLVLYRLL------------PPEIKEVPGSKEVIREELAELGPLSRREKIALAI 180

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462615790 346 FIIMALLWFSRDPGFVP-GWSALFSeypgfatdstvalligllfflipaktltkttptgeIVAFDYSPLITWKEFQSFMP 424
Cdd:COG0471   181 FALTVLLWITGSLHGIPiAVVALLG-----------------------------------AVLLLLTGVLTWKDAYKSIP 225

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462615790 425 WDIAILVGGGFALADGCEESGLSKWIGNKLSP-LGSLPAWLIILISSLMVTSLTEVASNPATITLFLPILSPLAEAIHVN 503
Cdd:COG0471   226 WGVLLLFGGGLALGAALEKTGLAAWLADALLPlLGGLSPLLLLLLLALLTLLLTEFASNTATAALLLPIAISLAQALGVN 305

                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462615790 504 PLYILIPSTLCTSFAFLLPVANPPNAIVFSYGHLKVIDMVKAGLGVNIVGVAVVMLGICTW 564
Cdd:COG0471   306 PLPLALAVAFAASCAFLLPVGTPPNAIVYGSGYYKFKDFLKVGLPLNLIGLVVLLLLGPLW 366
 
Name Accession Description Interval E-value
CitT COG0471
Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism];
26-564 1.54e-74

Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism];


Pssm-ID: 440239 [Multi-domain]  Cd Length: 369  Bit Score: 241.98  E-value: 1.54e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462615790  26 IGVICLATSIEKWNLHKRIALKMVMMVGVNPAWLTLGFMSSTAFLSMWLSNTSTAAMVMPIAEAVVQQiinaeaeveatq 105
Cdd:COG0471     1 LGGFVLAAALEKTGLGRRIALLLLKRFGGSPLRLLLGLMLATALLSAFISNTARAAMMLPIALSIAAA------------ 68

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462615790 106 mtyfngstnhgleidesvngheinerkektkpvpgynndtgkisskvelekeeeesnqqrvftgswvrkrmklllaytle 185
Cdd:COG0471       --------------------------------------------------------------------------------

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462615790 186 shllnktltfglvipqvkpfqdvplsknsgmrtkYRTKKGHVTRKLTCLCIAYSSTIGGLTTITGTSTNLIFAEYFNTRY 265
Cdd:COG0471    69 ----------------------------------LGSEKRSKFGSALLLPIAFAASIGGMGTLIGTPPNLIAAGLLEEAT 114

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462615790 266 PdcRCLNFGSWFTFSFPAALIILLLSWIWLQWLFlgfnfkemfkcgKTKTVQQKACAEVIKQEYQKLGPIRYQEIVTLVL 345
Cdd:COG0471   115 G--IPISFFEWMLVGLPVALVGLLLLWLVLYRLL------------PPEIKEVPGSKEVIREELAELGPLSRREKIALAI 180

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462615790 346 FIIMALLWFSRDPGFVP-GWSALFSeypgfatdstvalligllfflipaktltkttptgeIVAFDYSPLITWKEFQSFMP 424
Cdd:COG0471   181 FALTVLLWITGSLHGIPiAVVALLG-----------------------------------AVLLLLTGVLTWKDAYKSIP 225

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462615790 425 WDIAILVGGGFALADGCEESGLSKWIGNKLSP-LGSLPAWLIILISSLMVTSLTEVASNPATITLFLPILSPLAEAIHVN 503
Cdd:COG0471   226 WGVLLLFGGGLALGAALEKTGLAAWLADALLPlLGGLSPLLLLLLLALLTLLLTEFASNTATAALLLPIAISLAQALGVN 305

                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462615790 504 PLYILIPSTLCTSFAFLLPVANPPNAIVFSYGHLKVIDMVKAGLGVNIVGVAVVMLGICTW 564
Cdd:COG0471   306 PLPLALAVAFAASCAFLLPVGTPPNAIVYGSGYYKFKDFLKVGLPLNLIGLVVLLLLGPLW 366
SLC13_permease cd01115
Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been ...
 1-561 1.31e-43

Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is related to renal and intestinal Na+/sulfate cotransporters and a few putative bacterial permeases. The SLC13-type proteins belong to the ArsB/NhaD superfamily of permeases that translocate sodium and various anions across biological membranes in all three kingdoms of life. A typical ArsB/NhaD permease is composed of 8-13 transmembrane helices.


Pssm-ID: 238535 [Multi-domain]  Cd Length: 382  Bit Score: 160.06  E-value: 1.31e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462615790   1 MLPMFGIMPSKKVASAYFKDFHLLLIGVICLATSIEKWNLHKRIALKMVMMVGVNPAWLTLGFMSSTAFLSMWLSNTSTA 80
Cdd:cd01115    28 LLVLLGVVPPKEAFSGFSDPAVILFLAGFILGAALTRTGLAKRIATKLLKRAGKGERRLLLLLMLVTAFLSAFMSNTATV 107

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462615790  81 AMVMPIAEAVVqqiinaeaeveatqmtyfngstnhgleidesvngheineRKEKTKPVpgynndtgkisskvelekeeee 160
Cdd:cd01115   108 AIMLPVALGLA---------------------------------------AKLDISPS---------------------- 126

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462615790 161 snqqrvftgswvrkrmKLLLaytleshllnktltfglvipqvkpfqdvplsknsgmrtkyrtkkghvtrkltclCIAYSS 240
Cdd:cd01115   127 ----------------RLLM------------------------------------------------------PLAFAA 136

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462615790 241 TIGGLTTITGTSTNLIFAEYFNTRYPDCrcLNFGSWFTFSFPAALIILLLSWIWLQWLFLgfnfkemfkcgktktvqqka 320
Cdd:cd01115   137 SIGGMLTLIGTPPNLVASGYLESLGGQG--FSFFEFTPIGLPLLIIGLLYLWFIFRLAVL-------------------- 194

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462615790 321 caevikqeyqklgpiryqeIVTLVLFIIMALLwfsrdPGFVPgwsalfseypgfatdstvalligllfflipaktLTKTT 400
Cdd:cd01115   195 -------------------IITIVLLAALAAI-----TGLLP---------------------------------VSVAI 217

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462615790 401 PTGEIVAFDYSPLITWKEFQSFmPWDIAILVGGGFALADGCEESGLSKWIGNKLSP-LGSLPAWLIILISSLMVTSLTEV 479
Cdd:cd01115   218 AIGAIVLVFGGVLLTKEDYKSI-DWGIIFLFAGGIPLGKALESSGAAALIAEALISlLGGLPPFAILLLLCLLTLVLTNF 296

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462615790 480 ASNPATITLFLPILSPLAEAIHVNPLYILIPSTLCTSFAFLLPVANPPNAIVFSYGHLKVIDMVKAGLGVNIVGVAVVML 559
Cdd:cd01115   297 ISNTATAVLLAPIALSIALSLGLPPEALLLAVAIGASCAFMLPVGTPPNAIVLGPGGYKFSDFAKVGLPLSILSLVVSVT 376


                  ..
gi 2462615790 560 GI 561
Cdd:cd01115   377 MI 378
Na_sulph_symp pfam00939
Sodium:sulfate symporter transmembrane region; There are also some members in this family that ...
 13-569 3.81e-39

Sodium:sulfate symporter transmembrane region; There are also some members in this family that do not match the Prosite motif, and belong to the subfamily SODIT1.


Pssm-ID: 279307 [Multi-domain]  Cd Length: 472  Bit Score: 149.44  E-value: 3.81e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462615790  13 VASAYFKDFHLLLIGVICLATSIEKWNLHKRIALKMVMMVGVNPawLTLGFMSSTAFLSMWLSNTSTAAMVMPIAEAVVQ 92
Cdd:pfam00939  77 ALSGFSSTTTWLVFGAFFISAAFEKTGLGRRIALVLVKKMGKRT--LGLGYGLVFSDLLLAPATPSNTARAGGIVFPIIM 154

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462615790  93 QIINAeaeveatqmtyfNGSTnhgleidesvngheinerKEKTKPvpgynndtgkisskvelekeeeesnqqrvftgswv 172
Cdd:pfam00939 155 SLPPA------------FGSD------------------PEKGSE----------------------------------- 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462615790 173 rkrmKLLLAYTLeshllnktltfglvipqvkpfqdvplsknsgmrtkyrtkkghvtrkltcLCIAYSSTIGGLTTITGTS 252
Cdd:pfam00939 170 ----RRIGAYLM-------------------------------------------------WTVYQSTSITSAMFLTAMA 196

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462615790 253 TNLIFAEYFNTRYPDCrcLNFGSWFTFSFPAALIILLLSWIWLQWLFLGFNFKemfkcgktktvqQKACAEVIKQEYQKL 332
Cdd:pfam00939 197 PNLLLLGLMNSILGVT--ITWASWFLAAIPPGVILLLLAPLLLYVLYPPEIKS------------VPDAKAIAKTELKEL 262

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462615790 333 GPIRYQEIVTLVLFIIMALLWFsrdpgfvpgwsalFSEYPGFaTDSTVALLIGLLFFLipaktltkttptgeivafdySP 412
Cdd:pfam00939 263 GPMTFREKALLGLFVLLLLLWI-------------FGGSLNI-DATTVAIIGLALMLL--------------------LR 308

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462615790 413 LITWKE-FQSFMPWDIAILVGGGFALADGCEESGLSKWIGNKLSPL--GSLPAWLIILISSLMVTSLTEVASNPATITLF 489
Cdd:pfam00939 309 ILDWKDiVKNKGAWNTLIWLGGLIMLANGLERSGFIEWLGNTLSTSlsGFSPAMAFIIILSLFYLSHYLFASATAHTAAM 388

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462615790 490 LPILSPLAEAIH-VNPLYILIPSTLCTSFA-FLLPVANPPNAIVFSYGHLKVIDMVKAGLGVNIVGVAVVMLGICTWIVP 567
Cdd:pfam00939 389 LPIFAAVAQAIPgAPPLLAALLLGFAISLGgFLTPYGTGPGPIYFGSGYLKVKDWWRIGAILTIIGLLILLLLGNWWWKP 468


                  ..
gi 2462615790 568 MF 569
Cdd:pfam00939 469 LG 470
dass TIGR00785
anion transporter; The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally ...
 190-564 4.78e-33

anion transporter; The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally characterized proteins of the DASS family transport (1) organic di- and tricarboxylates of the Krebs Cycle as well as dicarboxylate amino acid, (2) inorganic sulfate and (3) phosphate. The animal NaDC-1 cotransport 3 Na+ with each dicarboxylate. Protonated tricarboxylates are also cotransported with 3Na+. [Transport and binding proteins, Anions, Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273267 [Multi-domain]  Cd Length: 444  Bit Score: 131.70  E-value: 4.78e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462615790 190 NKTLTFGLVIPQVKPFQDVPLSKNSGMRTKYRtkkghvtrKLTCLCIAYSSTIGGLTTITGTSTNLIFAEYfnTRYPDCR 269
Cdd:TIGR00785 121 NTARAGGILLPIIKSLLPLLGSKPEKSPRKIG--------KYLMLGIAYSASIGSSGFLTGSAPNALAAGI--LSKILGI 190

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462615790 270 CLNFGSWFTFSFPAALIILLLSWIWLQWLFlgfnfkemfkcgKTKTVQQKACAEVIKQEYQKLGPIRYQEIVTLVLFIIM 349
Cdd:TIGR00785 191 QISWGDWFLAGLPLGIILLLLVPLLLYVLF------------PPELKLKDEVDLWAKEELEEMGPMSFREKALLGIFLLA 258

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462615790 350 ALLWFSRDPGFVPgwsalfseypgfatDSTVALLIgllfflipaktltkttptgeIVAFDYSPLITWKEFQS-FMPWDIA 428
Cdd:TIGR00785 259 LLLWIFGGSLGIN--------------ASVVALLA--------------------VVLMLFLGIVTWKDIQKnKVAWNTL 304

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462615790 429 ILVGGGFALADGCEESGLSKWIGNKLSP--LGSLPAWLIILISSLMVTSLTEVASNPATITLFLPILSPLAEAIHVNPLY 506
Cdd:TIGR00785 305 ILFGGLIGLAGGLKKSGFIKWFSEKLVGilDGLSPTIAVLVLVVLFYIILYFFASNTAHTAALVPIFFSVASAQGIPLEL 384

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2462615790 507 ILIPSTLCTSFA-FLLPVANPPNAIVFSYGHLKVIDMVKAGLGVNIVGVAVVMLGICTW 564
Cdd:TIGR00785 385 LALALALSASLMgFLTPYATPPNAIAYGSGYVKIKDMWRVGAIIGIVGLIVLLLVGTLW 443
 
Name Accession Description Interval E-value
CitT COG0471
Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism];
26-564 1.54e-74

Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism];


Pssm-ID: 440239 [Multi-domain]  Cd Length: 369  Bit Score: 241.98  E-value: 1.54e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462615790  26 IGVICLATSIEKWNLHKRIALKMVMMVGVNPAWLTLGFMSSTAFLSMWLSNTSTAAMVMPIAEAVVQQiinaeaeveatq 105
Cdd:COG0471     1 LGGFVLAAALEKTGLGRRIALLLLKRFGGSPLRLLLGLMLATALLSAFISNTARAAMMLPIALSIAAA------------ 68

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462615790 106 mtyfngstnhgleidesvngheinerkektkpvpgynndtgkisskvelekeeeesnqqrvftgswvrkrmklllaytle 185
Cdd:COG0471       --------------------------------------------------------------------------------

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462615790 186 shllnktltfglvipqvkpfqdvplsknsgmrtkYRTKKGHVTRKLTCLCIAYSSTIGGLTTITGTSTNLIFAEYFNTRY 265
Cdd:COG0471    69 ----------------------------------LGSEKRSKFGSALLLPIAFAASIGGMGTLIGTPPNLIAAGLLEEAT 114

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462615790 266 PdcRCLNFGSWFTFSFPAALIILLLSWIWLQWLFlgfnfkemfkcgKTKTVQQKACAEVIKQEYQKLGPIRYQEIVTLVL 345
Cdd:COG0471   115 G--IPISFFEWMLVGLPVALVGLLLLWLVLYRLL------------PPEIKEVPGSKEVIREELAELGPLSRREKIALAI 180

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462615790 346 FIIMALLWFSRDPGFVP-GWSALFSeypgfatdstvalligllfflipaktltkttptgeIVAFDYSPLITWKEFQSFMP 424
Cdd:COG0471   181 FALTVLLWITGSLHGIPiAVVALLG-----------------------------------AVLLLLTGVLTWKDAYKSIP 225

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462615790 425 WDIAILVGGGFALADGCEESGLSKWIGNKLSP-LGSLPAWLIILISSLMVTSLTEVASNPATITLFLPILSPLAEAIHVN 503
Cdd:COG0471   226 WGVLLLFGGGLALGAALEKTGLAAWLADALLPlLGGLSPLLLLLLLALLTLLLTEFASNTATAALLLPIAISLAQALGVN 305

                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462615790 504 PLYILIPSTLCTSFAFLLPVANPPNAIVFSYGHLKVIDMVKAGLGVNIVGVAVVMLGICTW 564
Cdd:COG0471   306 PLPLALAVAFAASCAFLLPVGTPPNAIVYGSGYYKFKDFLKVGLPLNLIGLVVLLLLGPLW 366
SLC13_permease cd01115
Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been ...
 1-561 1.31e-43

Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is related to renal and intestinal Na+/sulfate cotransporters and a few putative bacterial permeases. The SLC13-type proteins belong to the ArsB/NhaD superfamily of permeases that translocate sodium and various anions across biological membranes in all three kingdoms of life. A typical ArsB/NhaD permease is composed of 8-13 transmembrane helices.


Pssm-ID: 238535 [Multi-domain]  Cd Length: 382  Bit Score: 160.06  E-value: 1.31e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462615790   1 MLPMFGIMPSKKVASAYFKDFHLLLIGVICLATSIEKWNLHKRIALKMVMMVGVNPAWLTLGFMSSTAFLSMWLSNTSTA 80
Cdd:cd01115    28 LLVLLGVVPPKEAFSGFSDPAVILFLAGFILGAALTRTGLAKRIATKLLKRAGKGERRLLLLLMLVTAFLSAFMSNTATV 107

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462615790  81 AMVMPIAEAVVqqiinaeaeveatqmtyfngstnhgleidesvngheineRKEKTKPVpgynndtgkisskvelekeeee 160
Cdd:cd01115   108 AIMLPVALGLA---------------------------------------AKLDISPS---------------------- 126

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462615790 161 snqqrvftgswvrkrmKLLLaytleshllnktltfglvipqvkpfqdvplsknsgmrtkyrtkkghvtrkltclCIAYSS 240
Cdd:cd01115   127 ----------------RLLM------------------------------------------------------PLAFAA 136

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462615790 241 TIGGLTTITGTSTNLIFAEYFNTRYPDCrcLNFGSWFTFSFPAALIILLLSWIWLQWLFLgfnfkemfkcgktktvqqka 320
Cdd:cd01115   137 SIGGMLTLIGTPPNLVASGYLESLGGQG--FSFFEFTPIGLPLLIIGLLYLWFIFRLAVL-------------------- 194

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462615790 321 caevikqeyqklgpiryqeIVTLVLFIIMALLwfsrdPGFVPgwsalfseypgfatdstvalligllfflipaktLTKTT 400
Cdd:cd01115   195 -------------------IITIVLLAALAAI-----TGLLP---------------------------------VSVAI 217

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462615790 401 PTGEIVAFDYSPLITWKEFQSFmPWDIAILVGGGFALADGCEESGLSKWIGNKLSP-LGSLPAWLIILISSLMVTSLTEV 479
Cdd:cd01115   218 AIGAIVLVFGGVLLTKEDYKSI-DWGIIFLFAGGIPLGKALESSGAAALIAEALISlLGGLPPFAILLLLCLLTLVLTNF 296

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462615790 480 ASNPATITLFLPILSPLAEAIHVNPLYILIPSTLCTSFAFLLPVANPPNAIVFSYGHLKVIDMVKAGLGVNIVGVAVVML 559
Cdd:cd01115   297 ISNTATAVLLAPIALSIALSLGLPPEALLLAVAIGASCAFMLPVGTPPNAIVLGPGGYKFSDFAKVGLPLSILSLVVSVT 376


                  ..
gi 2462615790 560 GI 561
Cdd:cd01115   377 MI 378
Na_sulph_symp pfam00939
Sodium:sulfate symporter transmembrane region; There are also some members in this family that ...
 13-569 3.81e-39

Sodium:sulfate symporter transmembrane region; There are also some members in this family that do not match the Prosite motif, and belong to the subfamily SODIT1.


Pssm-ID: 279307 [Multi-domain]  Cd Length: 472  Bit Score: 149.44  E-value: 3.81e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462615790  13 VASAYFKDFHLLLIGVICLATSIEKWNLHKRIALKMVMMVGVNPawLTLGFMSSTAFLSMWLSNTSTAAMVMPIAEAVVQ 92
Cdd:pfam00939  77 ALSGFSSTTTWLVFGAFFISAAFEKTGLGRRIALVLVKKMGKRT--LGLGYGLVFSDLLLAPATPSNTARAGGIVFPIIM 154

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462615790  93 QIINAeaeveatqmtyfNGSTnhgleidesvngheinerKEKTKPvpgynndtgkisskvelekeeeesnqqrvftgswv 172
Cdd:pfam00939 155 SLPPA------------FGSD------------------PEKGSE----------------------------------- 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462615790 173 rkrmKLLLAYTLeshllnktltfglvipqvkpfqdvplsknsgmrtkyrtkkghvtrkltcLCIAYSSTIGGLTTITGTS 252
Cdd:pfam00939 170 ----RRIGAYLM-------------------------------------------------WTVYQSTSITSAMFLTAMA 196

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462615790 253 TNLIFAEYFNTRYPDCrcLNFGSWFTFSFPAALIILLLSWIWLQWLFLGFNFKemfkcgktktvqQKACAEVIKQEYQKL 332
Cdd:pfam00939 197 PNLLLLGLMNSILGVT--ITWASWFLAAIPPGVILLLLAPLLLYVLYPPEIKS------------VPDAKAIAKTELKEL 262

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462615790 333 GPIRYQEIVTLVLFIIMALLWFsrdpgfvpgwsalFSEYPGFaTDSTVALLIGLLFFLipaktltkttptgeivafdySP 412
Cdd:pfam00939 263 GPMTFREKALLGLFVLLLLLWI-------------FGGSLNI-DATTVAIIGLALMLL--------------------LR 308

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462615790 413 LITWKE-FQSFMPWDIAILVGGGFALADGCEESGLSKWIGNKLSPL--GSLPAWLIILISSLMVTSLTEVASNPATITLF 489
Cdd:pfam00939 309 ILDWKDiVKNKGAWNTLIWLGGLIMLANGLERSGFIEWLGNTLSTSlsGFSPAMAFIIILSLFYLSHYLFASATAHTAAM 388

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462615790 490 LPILSPLAEAIH-VNPLYILIPSTLCTSFA-FLLPVANPPNAIVFSYGHLKVIDMVKAGLGVNIVGVAVVMLGICTWIVP 567
Cdd:pfam00939 389 LPIFAAVAQAIPgAPPLLAALLLGFAISLGgFLTPYGTGPGPIYFGSGYLKVKDWWRIGAILTIIGLLILLLLGNWWWKP 468


                  ..
gi 2462615790 568 MF 569
Cdd:pfam00939 469 LG 470
dass TIGR00785
anion transporter; The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally ...
 190-564 4.78e-33

anion transporter; The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally characterized proteins of the DASS family transport (1) organic di- and tricarboxylates of the Krebs Cycle as well as dicarboxylate amino acid, (2) inorganic sulfate and (3) phosphate. The animal NaDC-1 cotransport 3 Na+ with each dicarboxylate. Protonated tricarboxylates are also cotransported with 3Na+. [Transport and binding proteins, Anions, Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273267 [Multi-domain]  Cd Length: 444  Bit Score: 131.70  E-value: 4.78e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462615790 190 NKTLTFGLVIPQVKPFQDVPLSKNSGMRTKYRtkkghvtrKLTCLCIAYSSTIGGLTTITGTSTNLIFAEYfnTRYPDCR 269
Cdd:TIGR00785 121 NTARAGGILLPIIKSLLPLLGSKPEKSPRKIG--------KYLMLGIAYSASIGSSGFLTGSAPNALAAGI--LSKILGI 190

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462615790 270 CLNFGSWFTFSFPAALIILLLSWIWLQWLFlgfnfkemfkcgKTKTVQQKACAEVIKQEYQKLGPIRYQEIVTLVLFIIM 349
Cdd:TIGR00785 191 QISWGDWFLAGLPLGIILLLLVPLLLYVLF------------PPELKLKDEVDLWAKEELEEMGPMSFREKALLGIFLLA 258

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462615790 350 ALLWFSRDPGFVPgwsalfseypgfatDSTVALLIgllfflipaktltkttptgeIVAFDYSPLITWKEFQS-FMPWDIA 428
Cdd:TIGR00785 259 LLLWIFGGSLGIN--------------ASVVALLA--------------------VVLMLFLGIVTWKDIQKnKVAWNTL 304

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462615790 429 ILVGGGFALADGCEESGLSKWIGNKLSP--LGSLPAWLIILISSLMVTSLTEVASNPATITLFLPILSPLAEAIHVNPLY 506
Cdd:TIGR00785 305 ILFGGLIGLAGGLKKSGFIKWFSEKLVGilDGLSPTIAVLVLVVLFYIILYFFASNTAHTAALVPIFFSVASAQGIPLEL 384

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2462615790 507 ILIPSTLCTSFA-FLLPVANPPNAIVFSYGHLKVIDMVKAGLGVNIVGVAVVMLGICTW 564
Cdd:TIGR00785 385 LALALALSASLMgFLTPYATPPNAIAYGSGYVKIKDMWRVGAIIGIVGLIVLLLVGTLW 443
ArsB_NhaD_permease cd00625
Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, ...
 1-561 1.13e-23

Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a channel-forming subunit of an ATP-driven anion pump.


Pssm-ID: 238344 [Multi-domain]  Cd Length: 396  Bit Score: 103.48  E-value: 1.13e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462615790   1 MLPMFGIMPSKKVASAYFKDFHLLLIGVICLATSIEKWNLHKRIALKMVMmVGVNPAWLTLGFMSSTAFLSMWLSNTSTA 80
Cdd:cd00625    21 LLVLLGVVSPKEALSAIDWETILLLFGMMILSAALEETGLFDRLAAKLAR-ASKGSRRLLLLLMLLTAALSAFFSNDATA 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462615790  81 AMVMPIAEAVVQQiinaeaeveatqmtyfngstnhgleidesvngheinerkektkpvpgynndtgkisskvelekeeee 160
Cdd:cd00625   100 VLLTPIVLALLRK------------------------------------------------------------------- 112

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462615790 161 snqqrvftgswvrkrmklllaytleshllnktltfgLVIPQVKPFqdvplsknsgmrtkyrtkkghvtrkltCLCIAYSS 240
Cdd:cd00625   113 ------------------------------------LGLSPPVPL---------------------------LLALAFAA 129

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462615790 241 TIGGLTTITGTSTNLIFAEYFNtrypdcrcLNFGSWFTFSFPAALIILLLSWIWLQWLFLGFNFKEmfkcgktktvqQKA 320
Cdd:cd00625   130 NIGGAATPIGNPPNLIIASLSG--------LGFLDFLAFMAPPALGLLLLLLGLLYLLFRKKLLLP-----------DED 190

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462615790 321 CAEVIKQEYQKLGPIRYQEIVTLVLFIIMALLWFsrdpgfvpgwsalFSEYPGFATDSTVAlligllfflipaktltktt 400
Cdd:cd00625   191 KLTVLAEPLPARPLLKKFLLLALLLLLLFVLLFF-------------FLIPLGLIALLGAL------------------- 238

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462615790 401 ptgeIVAFDYSPLITWKEFQSFMPWDIAILVGGGFALADGCEESGLSKWIGNKLSPLGSLPAWLIILISSLMVTSLTEVA 480
Cdd:cd00625   239 ----LLLLLLVRGLDPEEVLKSVDWGTLLFFAGLFVLVGALESTGLLEWLAELLVALVGLPPLAALLLIGLLSALLSNFI 314

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462615790 481 SNPATITLFLPILSPLAEA-----IHVNPLYILIPSTLCTSFAFLLPVANPPNAIVfsygHLKVIDMVKAGLGVNIVGVA 555
Cdd:cd00625   315 SNVPTVALLLPIAASLAPPepawlALALGSTLGGNLTLIGSLANLIPLGAAENAGV----GISFGEFLKVGLPLTLLSLV 390


                  ....*.
gi 2462615790 556 VVMLGI 561
Cdd:cd00625   391 VSLLYL 396
CitMHS pfam03600
Citrate transporter;
405-587 4.31e-14

Citrate transporter;


Pssm-ID: 460985 [Multi-domain]  Cd Length: 342  Bit Score: 73.89  E-value: 4.31e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462615790 405 IVAFDYSPLITWKEFQSFMPWDIAILVGGGFALADGCEESGLSKWIGNKLSPLGSLPAWLIILISSLMVTSLTEVASNPA 484
Cdd:pfam03600  19 AVLLVLLGVLTPEEALSGIDSPTILLLLGMMIIGAILERTGLFDRLALKLLRLAGGKPRRLLVALMLATALLSAFLSNDG 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462615790 485 TITLFLPILSPLAEAIHVNPLYILIPSTLCTSFAFLL-PVANPPNAIVFSYGHLKVIDMVKAGLGVNIVGVAVVMLGICT 563
Cdd:pfam03600  99 TVLIMIPIVLALARRLGLPPSPLLIALAFAANIGGTAtPIGDPPNIIIASALGLSFGDFGFFMFPPVGVALLLVGLLPLL 178

                         170       180
                  ....*....|....*....|....
gi 2462615790 564 WIVPMFDLYTYPSWAPAMSNETMP 587
Cdd:pfam03600 179 LIFRKLLPVRKEEEAELEELRKRA 202
CitMHS pfam03600
Citrate transporter;
222-509 5.07e-13

Citrate transporter;


Pssm-ID: 460985 [Multi-domain]  Cd Length: 342  Bit Score: 70.42  E-value: 5.07e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462615790 222 TKKGHVTRKLTCLCIAYSSTIGGLTTITGTSTNLIFAEYFNtrypdcrcLNFGSWFTFSFPAALIILLLSWIWLQWLFLG 301
Cdd:pfam03600 111 ARRLGLPPSPLLIALAFAANIGGTATPIGDPPNIIIASALG--------LSFGDFGFFMFPPVGVALLLVGLLPLLLIFR 182

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462615790 302 FNFKEMFKcgktktvqqkacaevIKQEYQKLGPIRYQEIVTLVLFIIMALLWFSrdpGFVPGWSALFSeypgfatdstva 381
Cdd:pfam03600 183 KLLPVRKE---------------EEAELEELRKRAIKDKLLLAISALVLALVIL---GFLLLSVLALA------------ 232

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462615790 382 lligllfflipaktltkttptgEIVAFDYSPLITWKEFQSFMPWDIAILVGGGFALADGCEESGLSKWIGNKLSPLGslP 461
Cdd:pfam03600 233 ----------------------GALLLLLTGVLDPEEALKAVDWSTLLFFAGLFILVGALEKTGLADALADALGGLS--G 288

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 2462615790 462 AWLIILISSLMVTSLTEVASNPATITLFLPILSPLAEAIHVNPLYILI 509
Cdd:pfam03600 289 LLVALALILWLSALLSAFISNVPTAALMAPIIVGMAPAAGLGDPDPLA 336
ArsB_NhaD_permease cd00625
Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, ...
 413-571 1.28e-10

Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a channel-forming subunit of an ATP-driven anion pump.


Pssm-ID: 238344 [Multi-domain]  Cd Length: 396  Bit Score: 63.42  E-value: 1.28e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462615790 413 LITWKEFQSFMPWDIAILVGGGFALADGCEESGLSKWIGNKLSPLGSLPAWLIILIsSLMVTSLTEVASNPATITLFLPI 492
Cdd:cd00625    27 VVSPKEALSAIDWETILLLFGMMILSAALEETGLFDRLAAKLARASKGSRRLLLLL-MLLTAALSAFFSNDATAVLLTPI 105

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462615790 493 LSPLAEAIH-VNPLYILIPSTLCTSFA-FLLPVANPPNAIVFSYGHLKVIDMVKAGLGVNIVGVAVVMlgICTWIVPMFD 570
Cdd:cd00625   106 VLALLRKLGlSPPVPLLLALAFAANIGgAATPIGNPPNLIIASLSGLGFLDFLAFMAPPALGLLLLLL--GLLYLLFRKK 183


                  .
gi 2462615790 571 L 571
Cdd:cd00625   184 L 184
ArsB COG1055
Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism];
413-559 7.58e-08

Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism];


Pssm-ID: 440675 [Multi-domain]  Cd Length: 415  Bit Score: 54.75  E-value: 7.58e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462615790 413 LITWKEFQSFMPWDIAILVGGGFALADGCEESGLSKWIGNKLSPLGSLPAWLIILISSLMVTSLTEVASNPATITLFLPI 492
Cdd:COG1055    41 VVSLEDALEAIDWNTILFLLGMMIIVAILDESGFFEWLAIKLARRAKGSPRRLLWLLGLLTALLSAFLDNDTTALLLTPV 120

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2462615790 493 LSPLAEAIHVNPLYILIPSTLCTSFA-FLLPVANPPNAIVFSYGHLKVIDMVKAGLGVNIVGVAVVML 559
Cdd:COG1055   121 VLAIARRLGLNPVPFLIAIVFAANIGgAATPIGNPTNIMIASAGGLSFLDFLANLFPPSLVSLLVTLL 188
CitT COG0471
Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism];
433-567 3.72e-07

Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism];


Pssm-ID: 440239 [Multi-domain]  Cd Length: 369  Bit Score: 52.46  E-value: 3.72e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462615790 433 GGFALADGCEESGLSKWIGNK-LSPLGSLPAWLIILIsSLMVTSLTEVASNPATITLFLPILSPLAEAIHVN-----PLY 506
Cdd:COG0471     2 GGFVLAAALEKTGLGRRIALLlLKRFGGSPLRLLLGL-MLATALLSAFISNTARAAMMLPIALSIAAALGSEkrskfGSA 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462615790 507 ILIP---STLCTSFAFLlpVANPPNAIVFSY------GHLKVIDMVKAGLGVNIVGVAVVMLgICTWIVP 567
Cdd:COG0471    81 LLLPiafAASIGGMGTL--IGTPPNLIAAGLleeatgIPISFFEWMLVGLPVALVGLLLLWL-VLYRLLP 147
ArsB COG1055
Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism];
233-509 6.35e-05

Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism];


Pssm-ID: 440675 [Multi-domain]  Cd Length: 415  Bit Score: 45.50  E-value: 6.35e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462615790 233 CLCIAYSSTIGGLTTITGTSTNLIFAEYFNtrypdcrcLNFGSWFTFSFPAALIILLLSWIWLQWLFLGfnfkemfkcgk 312
Cdd:COG1055   136 LIAIVFAANIGGAATPIGNPTNIMIASAGG--------LSFLDFLANLFPPSLVSLLVTLLVLYLLFRK----------- 196

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462615790 313 tktvQQKACAEVIKQEYQKLGPIRYQEIVTLVLFIIMALLWFSRDPGFVPGWSALFSeypgfatdstvALLIGLLFFLIP 392
Cdd:COG1055   197 ----ELPAAPDLEDDPKEAIKDRRLLRISLLVLALLLVGFVLHSFLGLPPALIALLG-----------AAVLLLLARVDV 261

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462615790 393 AKTLTKttptgeivafdysplitwkefqsfMPWDIAILVGGGFALADGCEESGLSKWIGNKLSPLGSLPAWLIILISSLM 472
Cdd:COG1055   262 REVLKK------------------------VDWSTLLFFIGLFVVVGGLENTGLLDLLAELLASLTGGNLLLAALLILWL 317

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 2462615790 473 VTSLTEVASNPATITLFLPILSPLAEAIHVNPLYILI 509
Cdd:COG1055   318 SAILSAVVDNVPLVAALLPLIPDLGATGNPEPLWLAL 354
P_permease cd01116
Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible ...
 410-565 2.91e-04

Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the intraorganelle pH, together with the ATP-driven proton pump. It shows significant sequence similarity to the Na+/H+ antiporter NhaD from Vibrio parahaemolyticus. Both proteins belong to ArsB/NhaD superfamily of permeases that translocate sodium, arsenate, sulfate, and organic anions across biological membranes in all three kingdoms of life. A typical ArsB/NhaD permease contains 8-13 transmembrane domains.


Pssm-ID: 238536 [Multi-domain]  Cd Length: 413  Bit Score: 43.39  E-value: 2.91e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462615790 410 YSPLITWKEFQSFMPWDIAILVGGGFALADGCEESGLSKWIGNKLSPLGSLPAWLIILISSLMVTSLTEVASNPATITLF 489
Cdd:cd01116    32 ATLSPDLETIVSWVDWETLALLLGMMIIVSILSETGVFEYLAIWAVKISKGRPWRLLLLLGLLTAFLSAFLDNVTTVLLM 111

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2462615790 490 LPILSPLAEAIHVNPLYILIPSTLCTSF-AFLLPVANPPNAIVFSYGHLKVIDMVkAGLGVNIVGVAVVMLGICTWI 565
Cdd:cd01116   112 VPVTIRLCEVLGLNPVPVLISEVIAANIgGAATLIGDPPNIMIGSAAGLTFNDFL-LHMLPSVVLALVVTFILLYFL 187
ArsB_permease cd01118
Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in ...
 425-537 9.35e-04

Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a channel-forming subunit of an ATP-driven anion pump (ArsAB). The ArsAB complex is similar in many ways to ATP-binding cassette transporters, which have two groups of six transmembrane-spanning helical segments and two nucleotide-binding domains. The ArsB proteins belong to the ArsB/NhaD superfamily of permeases that translocate sodium, arsenate, sulfate, and organic anions across biological membranes in all three kingdoms of life.


Pssm-ID: 238538 [Multi-domain]  Cd Length: 416  Bit Score: 41.87  E-value: 9.35e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462615790 425 WDIAILVGGGFALADGCEESGLSKWIGNKLSPL----GSLPAWLIILISSLMvtslTEVASNPATITLFLPILSPLAEAI 500
Cdd:cd01118    52 WDVTLTLIGVILLSLLLDEEGFFEWVAALAARWargsGRKLFTLIVLLGAAV----TAFFANDGTALILTPIVIALLRAL 127

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 2462615790 501 HVNPL----YILIPSTLCTSFAFLLPVANPPNAIVFSYGHL 537
Cdd:cd01118   128 GAKKNrtlpFLYACAFIADAASLPLPISNLVNIVTAGYFGI 168
ArsB COG1055
Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism];
234-300 4.32e-03

Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism];


Pssm-ID: 440675 [Multi-domain]  Cd Length: 415  Bit Score: 39.73  E-value: 4.32e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2462615790 234 LCIAYSSTIGGLTTITGTSTNLIFAEYFNTRYpdcRCLNFGSWFTFSFPAALIILLLSWIWLQWLFL 300
Cdd:COG1055   352 LALALGATLGGNLTPIGSAANVIVLGIAEKKG---IKISFGEFLKVGLPLTLLTLLIALLYLLLLYF 415
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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