NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|2462619102|ref|XP_054216309|]
View 

probable C-mannosyltransferase DPY19L4 isoform X2 [Homo sapiens]

Protein Classification

Dpy19 superfamily-containing protein( domain architecture ID 1903530)

Dpy19 superfamily-containing protein

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

Name Accession Description Interval E-value
Dpy19 super family cl41786
C-mannosyltransferase Dpy19; Dpy19 proteins are C-mannosyltransferases that mediate ...
125-755 0e+00

C-mannosyltransferase Dpy19; Dpy19 proteins are C-mannosyltransferases that mediate C-mannosylation of tryptophan residues on target proteins. C-mannosylation is the attachment of alpha-mannose to the indole C2 carbon of the first tryptophan residue in the consensus amino acid sequence Trp-Xaa-Xaa-Trp/Cys through a C-C bond. This reaction takes place in the endoplasmic reticulum (ER) lumen. Dpy19 is a transmembrane domain family whose name is derived from the Caenorhabditis elegans Dumpy mutant.


The actual alignment was detected with superfamily member cd20180:

Pssm-ID: 455131  Cd Length: 664  Bit Score: 1240.49  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462619102 125 KIFIGCLAAVTSGMMYALYLSAYHERKFWFSNRQELEREITFQGDSAIYYSYYKDMLKAPSFERGVYELTHNNKTVSLKT 204
Cdd:cd20180     1 KIFFGCLAAVTSGMMYAVYLSTYHERKFWFSNRQELEREITFQGDSAIYYSYYKDMLKAPSFERGVYELTHNNKTVSLKT 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462619102 205 INAVQQMSLYPELIASILYQATGSNEIIEPVYFYIGIVFGLQGIYVTALFVTSWLMSGTWLAGMLTVAWFVINRVDTTRI 284
Cdd:cd20180    81 INAVQQMSLYPELIASVLYQATGSNEVIEPVYFYIGIVFGLQGIYVTALFVTSWLMSGTWLAGMLTVAWFIINRVDTTRI 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462619102 285 EYSIPLRENWALPYFACQIAALTGYLKSNLNTYGERFCYLLMSASTYTFMMMWEYSHYLLFLQAISLFLLDTFSVEQSDK 364
Cdd:cd20180   161 EYSIPLRENWALPYFACQVAALTGYLKSNLNTYAERFCYLLMSASTYTFMMMWEYSHYVLFLQAISLFLLDSFSLEQSDK 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462619102 365 VYEVYKIYIFSLFLGYLLQFENPALLVSPLLSLVAALMLAKCLQ---------------------------------MFV 411
Cdd:cd20180   241 VYEVYKVYLFSLFLGYLLQFENPALLVSPLLSLVAALMLAKCLQlnmkkgpfvakmikvlhfylvctltitlnfimkMFV 320
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462619102 412 PHKENGHMLKFLEVKFGLNMTKNFTMNWLLCQESLQAPSQDFFLRLTQSSLLPFYILVLIICFLSMLQVIFRRINGKSLK 491
Cdd:cd20180   321 PHKENEHLLKFLEVKFGLNTTKNFTMNWLLCQESLQAPSQDFFLRLTQSSLLPFYILVLIICLLSMLQVIFRRLSGKPLK 400
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462619102 492 ETVTLEDGRIGERPEIIYHVIHTILLGSLAMVIEGLKYIWIPYVCMLAAFGVCSPELWMTLFKWLRLRTVHPILLALILS 571
Cdd:cd20180   401 ETVTLEDGRIGERPEIVYHVIHTILLGSLAMLFEGMKYLWTPYVCMLAAFGVCSPELWMTLFKWLRLRTVHPILLALILS 480
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462619102 572 MAVPTIIGLSLWKEFFPRLMTELMELQEFYDPDTVELMTWIKRQAPVAAVFAGSPQLMGAIKLCTGWMVTSLPLYNDDDL 651
Cdd:cd20180   481 MAVPTIIGFSLWKEFFPRLMTELSELQEFYDPDTVELMTWIKRQAPVAAVFAGSPQLMGTIKLCTGWMVTSLPLYNDDDL 560
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462619102 652 LKRNENIYQIYSKRSAEDIYKILTSYKANYLIVEDAICNEVGPMRGCRVKDLLDIANGHMVCEEGDKLTYSKYGRFCHEV 731
Cdd:cd20180   561 LKRNENIYQIYSKRSAEDIYKILTSYKANYLIIEDAICNEVGPVRGCRVKDLLDIANGHVVCEEGDKYTYSKYGRFCHEI 640
                         650       660
                  ....*....|....*....|....
gi 2462619102 732 KINYSPYVNYFTRVYWNRSYFVYK 755
Cdd:cd20180   641 KINYSPYVNYFTRVYWNRSYFVYK 664
 
Name Accession Description Interval E-value
Dpy19L4 cd20180
C-mannosyltransferase Dpy-19-like protein 4 (Dpy19L4); Dpy19 proteins are ...
125-755 0e+00

C-mannosyltransferase Dpy-19-like protein 4 (Dpy19L4); Dpy19 proteins are C-mannosyltransferases that mediate C-mannosylation of tryptophan residues on target proteins. C-mannosylation is the attachment of alpha-mannose to the indole C2 carbon of the first tryptophan residue in the consensus amino acid sequence Trp-Xaa-Xaa-Trp/Cys through a C-C bond. This reaction takes place in the endoplasmic reticulum (ER) lumen. Dpy19 is a transmembrane domain family whose name is derived from the Caenorhabditis elegans Dumpy mutant. The function of Dpy19L4 (also called protein Dpy-19 homolog 4) is unknown.


Pssm-ID: 439133  Cd Length: 664  Bit Score: 1240.49  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462619102 125 KIFIGCLAAVTSGMMYALYLSAYHERKFWFSNRQELEREITFQGDSAIYYSYYKDMLKAPSFERGVYELTHNNKTVSLKT 204
Cdd:cd20180     1 KIFFGCLAAVTSGMMYAVYLSTYHERKFWFSNRQELEREITFQGDSAIYYSYYKDMLKAPSFERGVYELTHNNKTVSLKT 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462619102 205 INAVQQMSLYPELIASILYQATGSNEIIEPVYFYIGIVFGLQGIYVTALFVTSWLMSGTWLAGMLTVAWFVINRVDTTRI 284
Cdd:cd20180    81 INAVQQMSLYPELIASVLYQATGSNEVIEPVYFYIGIVFGLQGIYVTALFVTSWLMSGTWLAGMLTVAWFIINRVDTTRI 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462619102 285 EYSIPLRENWALPYFACQIAALTGYLKSNLNTYGERFCYLLMSASTYTFMMMWEYSHYLLFLQAISLFLLDTFSVEQSDK 364
Cdd:cd20180   161 EYSIPLRENWALPYFACQVAALTGYLKSNLNTYAERFCYLLMSASTYTFMMMWEYSHYVLFLQAISLFLLDSFSLEQSDK 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462619102 365 VYEVYKIYIFSLFLGYLLQFENPALLVSPLLSLVAALMLAKCLQ---------------------------------MFV 411
Cdd:cd20180   241 VYEVYKVYLFSLFLGYLLQFENPALLVSPLLSLVAALMLAKCLQlnmkkgpfvakmikvlhfylvctltitlnfimkMFV 320
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462619102 412 PHKENGHMLKFLEVKFGLNMTKNFTMNWLLCQESLQAPSQDFFLRLTQSSLLPFYILVLIICFLSMLQVIFRRINGKSLK 491
Cdd:cd20180   321 PHKENEHLLKFLEVKFGLNTTKNFTMNWLLCQESLQAPSQDFFLRLTQSSLLPFYILVLIICLLSMLQVIFRRLSGKPLK 400
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462619102 492 ETVTLEDGRIGERPEIIYHVIHTILLGSLAMVIEGLKYIWIPYVCMLAAFGVCSPELWMTLFKWLRLRTVHPILLALILS 571
Cdd:cd20180   401 ETVTLEDGRIGERPEIVYHVIHTILLGSLAMLFEGMKYLWTPYVCMLAAFGVCSPELWMTLFKWLRLRTVHPILLALILS 480
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462619102 572 MAVPTIIGLSLWKEFFPRLMTELMELQEFYDPDTVELMTWIKRQAPVAAVFAGSPQLMGAIKLCTGWMVTSLPLYNDDDL 651
Cdd:cd20180   481 MAVPTIIGFSLWKEFFPRLMTELSELQEFYDPDTVELMTWIKRQAPVAAVFAGSPQLMGTIKLCTGWMVTSLPLYNDDDL 560
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462619102 652 LKRNENIYQIYSKRSAEDIYKILTSYKANYLIVEDAICNEVGPMRGCRVKDLLDIANGHMVCEEGDKLTYSKYGRFCHEV 731
Cdd:cd20180   561 LKRNENIYQIYSKRSAEDIYKILTSYKANYLIIEDAICNEVGPVRGCRVKDLLDIANGHVVCEEGDKYTYSKYGRFCHEI 640
                         650       660
                  ....*....|....*....|....
gi 2462619102 732 KINYSPYVNYFTRVYWNRSYFVYK 755
Cdd:cd20180   641 KINYSPYVNYFTRVYWNRSYFVYK 664
Dpy19 pfam10034
Q-cell neuroblast polarization; Dyp-19, formerly known as DUF2211, is a transmembrane domain ...
134-756 0e+00

Q-cell neuroblast polarization; Dyp-19, formerly known as DUF2211, is a transmembrane domain family that is required to orient the neuroblast cells, QR and QL accurately on the anterior-posterior axis: QL and QR are born in the same anterior-posterior position, but polarise and migrate left-right asymmetrically, QL migrating towards the posterior and QR migrating towards the anterior. It is also required, with unc-40, to express mab-5 correctly in the Q cell descendants. The Dpy-19 protein derives from the C. elegans DUMPY mutant, Swiss:P34413.


Pssm-ID: 462945  Cd Length: 646  Bit Score: 816.07  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462619102 134 VTSGMMYALYLSAYHERKFWFSNRQELEREITFQGDSAIYYSYYKDMLKAPSFERGVYELTHNNKTVSLKTINAVQQMSL 213
Cdd:pfam10034   1 VGSGILYALHVSTLFENDRWFSHLSELEREISFRTEMGLYYSYYKTIIEAPSFLEGLYQLMNDNRTEYPDTINALQRFNL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462619102 214 YPELIASILYQATGS--NEIIEPVYFYIGIVFGLQGIYVTALFVTSWLMSGTWLAGMLTVAWFVINRVDTTRIEYSIPLR 291
Cdd:pfam10034  81 YPEVILAILYRIFRGiqNYLGEPVYFYIYFVFGLQGVYVSALFLYGWYLSGSWLGGILAVLWFFFNHGETTRVEWTPPLR 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462619102 292 ENWALPYFACQIAALTGYLKS-NLNTYGERFCYLLMSASTYTFMMMWEYSHYLLFLQAISLFLLDTFSVEQSDKVYEVYK 370
Cdd:pfam10034 161 ENFALPFFALQMLALTYILKRkNISSASELFCYILLSASTFLFLLTWQFSQFVLLTQILSLFLLDSLGLVPSKKVAKIYL 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462619102 371 IYIFSLFLGYLLQFENPALLVSPLLSLVAALMLAKCLQM----------------------------------FVPHKEN 416
Cdd:pfam10034 241 SHLISLLLAFVLQFGNSMLLTSPLLSSLISILLIRYLQPnmkkgrfsfrllklllhgllvlfgtltlkllikkLLNVEDD 320
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462619102 417 GHMLKFLEVKFGLNMTKNFTMNWLLCQESLQAPSQDFFLRLTQSSLLPFYILVLIICFLSMLQVIFRRINGKSL-----K 491
Cdd:pfam10034 321 AHIFDFLKAKFGLNSTRDFDTNLYTCAEEFDFLSKETFLRLTKTLLLPFYILVLLILLIKVLQSIYRRLKRYKLsqapmQ 400
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462619102 492 ETVTLEDGRIGERP----EIIYHVIHTILLGSLAMVIEGLKYIWIPYVCMLAAFGvCSPELWMTLFKWlrlrtvhpilla 567
Cdd:pfam10034 401 ESLPLEDGRIGERPelngEVVYHVLQLLAFGLLALLIMRLKLLWTPHMCVFASLG-ASKQLWHFLFKK------------ 467
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462619102 568 lILSMAVPTIIGLSLWKEFFPRLMTELMELQEFYDPDTVELMTWIKRQAPVAAVFAGSPQLMGAIKLCTGWMVTSLPLYN 647
Cdd:pfam10034 468 -IFSSAVPTVILASMSYKGFPNIQEELSILGEFYNPDTEELMEWIKSNTPKDAVFAGSMPLMATVKLSTGRPIVNHPHYE 546
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462619102 648 DDDLLKRNENIYQIYSKRSAEDIYKILTSYKANYLIVEDAICNEVGPMRGCRVKDLLDIANGHMvceegdkLTYSKYGRF 727
Cdd:pfam10034 547 DAGLRERTEDVYSVYSRKPAEDVYKILTSLKVNYVILEDSICSERSRRRGCRMLDIWDVEDGHC-------PANRKGPRF 619
                         650       660
                  ....*....|....*....|....*....
gi 2462619102 728 CHEVKinYSPYVNYFTRVYWNRSYFVYKI 756
Cdd:pfam10034 620 CHEIK--LSNYVPYFTRVFWNRSYHVYKV 646
 
Name Accession Description Interval E-value
Dpy19L4 cd20180
C-mannosyltransferase Dpy-19-like protein 4 (Dpy19L4); Dpy19 proteins are ...
125-755 0e+00

C-mannosyltransferase Dpy-19-like protein 4 (Dpy19L4); Dpy19 proteins are C-mannosyltransferases that mediate C-mannosylation of tryptophan residues on target proteins. C-mannosylation is the attachment of alpha-mannose to the indole C2 carbon of the first tryptophan residue in the consensus amino acid sequence Trp-Xaa-Xaa-Trp/Cys through a C-C bond. This reaction takes place in the endoplasmic reticulum (ER) lumen. Dpy19 is a transmembrane domain family whose name is derived from the Caenorhabditis elegans Dumpy mutant. The function of Dpy19L4 (also called protein Dpy-19 homolog 4) is unknown.


Pssm-ID: 439133  Cd Length: 664  Bit Score: 1240.49  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462619102 125 KIFIGCLAAVTSGMMYALYLSAYHERKFWFSNRQELEREITFQGDSAIYYSYYKDMLKAPSFERGVYELTHNNKTVSLKT 204
Cdd:cd20180     1 KIFFGCLAAVTSGMMYAVYLSTYHERKFWFSNRQELEREITFQGDSAIYYSYYKDMLKAPSFERGVYELTHNNKTVSLKT 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462619102 205 INAVQQMSLYPELIASILYQATGSNEIIEPVYFYIGIVFGLQGIYVTALFVTSWLMSGTWLAGMLTVAWFVINRVDTTRI 284
Cdd:cd20180    81 INAVQQMSLYPELIASVLYQATGSNEVIEPVYFYIGIVFGLQGIYVTALFVTSWLMSGTWLAGMLTVAWFIINRVDTTRI 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462619102 285 EYSIPLRENWALPYFACQIAALTGYLKSNLNTYGERFCYLLMSASTYTFMMMWEYSHYLLFLQAISLFLLDTFSVEQSDK 364
Cdd:cd20180   161 EYSIPLRENWALPYFACQVAALTGYLKSNLNTYAERFCYLLMSASTYTFMMMWEYSHYVLFLQAISLFLLDSFSLEQSDK 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462619102 365 VYEVYKIYIFSLFLGYLLQFENPALLVSPLLSLVAALMLAKCLQ---------------------------------MFV 411
Cdd:cd20180   241 VYEVYKVYLFSLFLGYLLQFENPALLVSPLLSLVAALMLAKCLQlnmkkgpfvakmikvlhfylvctltitlnfimkMFV 320
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462619102 412 PHKENGHMLKFLEVKFGLNMTKNFTMNWLLCQESLQAPSQDFFLRLTQSSLLPFYILVLIICFLSMLQVIFRRINGKSLK 491
Cdd:cd20180   321 PHKENEHLLKFLEVKFGLNTTKNFTMNWLLCQESLQAPSQDFFLRLTQSSLLPFYILVLIICLLSMLQVIFRRLSGKPLK 400
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462619102 492 ETVTLEDGRIGERPEIIYHVIHTILLGSLAMVIEGLKYIWIPYVCMLAAFGVCSPELWMTLFKWLRLRTVHPILLALILS 571
Cdd:cd20180   401 ETVTLEDGRIGERPEIVYHVIHTILLGSLAMLFEGMKYLWTPYVCMLAAFGVCSPELWMTLFKWLRLRTVHPILLALILS 480
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462619102 572 MAVPTIIGLSLWKEFFPRLMTELMELQEFYDPDTVELMTWIKRQAPVAAVFAGSPQLMGAIKLCTGWMVTSLPLYNDDDL 651
Cdd:cd20180   481 MAVPTIIGFSLWKEFFPRLMTELSELQEFYDPDTVELMTWIKRQAPVAAVFAGSPQLMGTIKLCTGWMVTSLPLYNDDDL 560
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462619102 652 LKRNENIYQIYSKRSAEDIYKILTSYKANYLIVEDAICNEVGPMRGCRVKDLLDIANGHMVCEEGDKLTYSKYGRFCHEV 731
Cdd:cd20180   561 LKRNENIYQIYSKRSAEDIYKILTSYKANYLIIEDAICNEVGPVRGCRVKDLLDIANGHVVCEEGDKYTYSKYGRFCHEI 640
                         650       660
                  ....*....|....*....|....
gi 2462619102 732 KINYSPYVNYFTRVYWNRSYFVYK 755
Cdd:cd20180   641 KINYSPYVNYFTRVYWNRSYFVYK 664
Dpy19 pfam10034
Q-cell neuroblast polarization; Dyp-19, formerly known as DUF2211, is a transmembrane domain ...
134-756 0e+00

Q-cell neuroblast polarization; Dyp-19, formerly known as DUF2211, is a transmembrane domain family that is required to orient the neuroblast cells, QR and QL accurately on the anterior-posterior axis: QL and QR are born in the same anterior-posterior position, but polarise and migrate left-right asymmetrically, QL migrating towards the posterior and QR migrating towards the anterior. It is also required, with unc-40, to express mab-5 correctly in the Q cell descendants. The Dpy-19 protein derives from the C. elegans DUMPY mutant, Swiss:P34413.


Pssm-ID: 462945  Cd Length: 646  Bit Score: 816.07  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462619102 134 VTSGMMYALYLSAYHERKFWFSNRQELEREITFQGDSAIYYSYYKDMLKAPSFERGVYELTHNNKTVSLKTINAVQQMSL 213
Cdd:pfam10034   1 VGSGILYALHVSTLFENDRWFSHLSELEREISFRTEMGLYYSYYKTIIEAPSFLEGLYQLMNDNRTEYPDTINALQRFNL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462619102 214 YPELIASILYQATGS--NEIIEPVYFYIGIVFGLQGIYVTALFVTSWLMSGTWLAGMLTVAWFVINRVDTTRIEYSIPLR 291
Cdd:pfam10034  81 YPEVILAILYRIFRGiqNYLGEPVYFYIYFVFGLQGVYVSALFLYGWYLSGSWLGGILAVLWFFFNHGETTRVEWTPPLR 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462619102 292 ENWALPYFACQIAALTGYLKS-NLNTYGERFCYLLMSASTYTFMMMWEYSHYLLFLQAISLFLLDTFSVEQSDKVYEVYK 370
Cdd:pfam10034 161 ENFALPFFALQMLALTYILKRkNISSASELFCYILLSASTFLFLLTWQFSQFVLLTQILSLFLLDSLGLVPSKKVAKIYL 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462619102 371 IYIFSLFLGYLLQFENPALLVSPLLSLVAALMLAKCLQM----------------------------------FVPHKEN 416
Cdd:pfam10034 241 SHLISLLLAFVLQFGNSMLLTSPLLSSLISILLIRYLQPnmkkgrfsfrllklllhgllvlfgtltlkllikkLLNVEDD 320
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462619102 417 GHMLKFLEVKFGLNMTKNFTMNWLLCQESLQAPSQDFFLRLTQSSLLPFYILVLIICFLSMLQVIFRRINGKSL-----K 491
Cdd:pfam10034 321 AHIFDFLKAKFGLNSTRDFDTNLYTCAEEFDFLSKETFLRLTKTLLLPFYILVLLILLIKVLQSIYRRLKRYKLsqapmQ 400
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462619102 492 ETVTLEDGRIGERP----EIIYHVIHTILLGSLAMVIEGLKYIWIPYVCMLAAFGvCSPELWMTLFKWlrlrtvhpilla 567
Cdd:pfam10034 401 ESLPLEDGRIGERPelngEVVYHVLQLLAFGLLALLIMRLKLLWTPHMCVFASLG-ASKQLWHFLFKK------------ 467
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462619102 568 lILSMAVPTIIGLSLWKEFFPRLMTELMELQEFYDPDTVELMTWIKRQAPVAAVFAGSPQLMGAIKLCTGWMVTSLPLYN 647
Cdd:pfam10034 468 -IFSSAVPTVILASMSYKGFPNIQEELSILGEFYNPDTEELMEWIKSNTPKDAVFAGSMPLMATVKLSTGRPIVNHPHYE 546
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462619102 648 DDDLLKRNENIYQIYSKRSAEDIYKILTSYKANYLIVEDAICNEVGPMRGCRVKDLLDIANGHMvceegdkLTYSKYGRF 727
Cdd:pfam10034 547 DAGLRERTEDVYSVYSRKPAEDVYKILTSLKVNYVILEDSICSERSRRRGCRMLDIWDVEDGHC-------PANRKGPRF 619
                         650       660
                  ....*....|....*....|....*....
gi 2462619102 728 CHEVKinYSPYVNYFTRVYWNRSYFVYKI 756
Cdd:pfam10034 620 CHEIK--LSNYVPYFTRVFWNRSYHVYKV 646
Dpy19 cd20177
C-mannosyltransferase Dpy19; Dpy19 proteins are C-mannosyltransferases that mediate ...
125-753 0e+00

C-mannosyltransferase Dpy19; Dpy19 proteins are C-mannosyltransferases that mediate C-mannosylation of tryptophan residues on target proteins. C-mannosylation is the attachment of alpha-mannose to the indole C2 carbon of the first tryptophan residue in the consensus amino acid sequence Trp-Xaa-Xaa-Trp/Cys through a C-C bond. This reaction takes place in the endoplasmic reticulum (ER) lumen. Dpy19 is a transmembrane domain family whose name is derived from the Caenorhabditis elegans Dumpy mutant.


Pssm-ID: 439130  Cd Length: 657  Bit Score: 709.80  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462619102 125 KIFIGCLAAVTSGMMYALYLSAYHERKFWFSNRQELEREITFQGDSAIYYSYYKDMLKAPSFERGVYELTHNNKTVSLKT 204
Cdd:cd20177     1 KILLGLLLALLVGVLYSLHLSTLFENDRHFSHLSELEREMTFRTEMGLYYSYYKQLIEAPSFLEGLYKLTHDNVTEYPHT 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462619102 205 INAVQQMSLYPELIASILYQATGSNE--------------------------IIEPVYFYIGIVFGLQGIYVTALFVTSW 258
Cdd:cd20177    81 INTLKRFNLYPEVILAILYRVFPSIAnyfgiptkqcwqvrgedlppvescegLGEPAYFYIYVVFGLNGLVAGLLFLYGW 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462619102 259 LMSGTWLAGMLTVAWFVINRVDTTRIEYSIPLRENWALPYFACQIAALTGYLKSNLntyGERFCYLLMSASTYTFMMMWE 338
Cdd:cd20177   161 LLSGSILGGLLTVAFFFFNHGEATRVQWTPPLRESFAYPFLLLQILLITIYLRSNI---GKRFHLLAISISTFLFMLMWQ 237
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462619102 339 YSHYLLFLQAISLFLLDTFSVEQSDKVYEVYKIYIFSLFLGYLLQFENP------------------------------- 387
Cdd:cd20177   238 FSQFALLTQILSLFALYVLGYIPSSKVQTIILSHLISLLLAFVLLFGNEmlltslylssllafliilylqlrlkksfkfk 317
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462619102 388 --ALLVSPLLSLVAALMLAKCLQMFVPHKENGHMLKFLEVKFGLNmtKNFTMNWLLCQESLQAPSQDFFLRLTQSSLLPF 465
Cdd:cd20177   318 liIWLLQLILVFLGTLGLKLLLSKLLNVEDDAHIFKILKSKFGDY--RDFDTRLYTCAAEFDFLSLETFLRLSKTLLLPL 395
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462619102 466 YILVLIICFLSMLQVIFRRINGKSLKETVTLEDGRIGERPEIIYHVIHTILLGSLAMVIEGLKYIWIPYVCMLAAFGVCS 545
Cdd:cd20177   396 YIVVLVVIAFLFLRVRLLTLNDSTLKESVNFTDSRLILNPEIVYNVLQLLAFGLLAILIMRLKLFWTPHMCILASLLLSK 475
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462619102 546 PELWMTLFKWlrlRTVHPILLALILSMAVPTIiglslwkeffPRLMTELMELQEFYDPDTVELMTWIKRQAPVAAVFAGS 625
Cdd:cd20177   476 KLLWKLLLKK---IFRLAVLFALLASMSYPGI----------PNLQEELSILGEFSNPDTEELMEWIKDNTPPDAVFAGS 542
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462619102 626 PQLMGAIKLCTGWMVTSLPLYNDDDLLKRNENIYQIYSKRSAEDIYKILTSYKANYLIVEDAICNEVGPmRGCRVKDLLD 705
Cdd:cd20177   543 MPLMANVKLSTGRPIVNHPHYEDAGLRERTKQVYSMYSRRPAEEVYNILKKLGVNYIILEDSICLSRRR-DGCSLPDIWD 621
                         650       660       670       680
                  ....*....|....*....|....*....|....*....|....*...
gi 2462619102 706 IANGHMVCEEGDKltyskygrfcheVKINYSPYVNYFTRVYWNRSYFV 753
Cdd:cd20177   622 LEDPHNRGKPPLC------------IRLLLEDYVPYFKLVFSNKTYRV 657
Dpy19L3 cd20181
C-mannosyltransferase Dpy-19-like protein 3 (Dpy19L3); Dpy19 proteins are ...
128-756 0e+00

C-mannosyltransferase Dpy-19-like protein 3 (Dpy19L3); Dpy19 proteins are C-mannosyltransferases that mediate C-mannosylation of tryptophan residues on target proteins. C-mannosylation is the attachment of alpha-mannose to the indole C2 carbon of the first tryptophan residue in the consensus amino acid sequence Trp-Xaa-Xaa-Trp/Cys through a C-C bond. This reaction takes place in the endoplasmic reticulum (ER) lumen. Dpy19 is a transmembrane domain family whose name is derived from the Caenorhabditis elegans Dumpy mutant. In humans Dpy19L3 (also called protein Dpy-19 homolog 3) is a C-mannosyltransferase of R-spondin.


Pssm-ID: 439134  Cd Length: 667  Bit Score: 573.71  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462619102 128 IGCLAAVTSGMMYALYLSAYHERKFWFSNRQELEREITFQGDSAIYYSYYKDMLKAPSFERGVYELTHNNKTVSLKTINA 207
Cdd:cd20181     4 VGGTVALCIGLLTSVYVATLHENDLWFSNIKEVEREISFRTECGLYYSYYKQMLQAPSIQQGFHGLIYDNKTESMRTINL 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462619102 208 VQQMSLYPELIASILYQATGSNEIIEPVYFYIGIVFGLQGIYVTALFVTSWLMSGTWLAGMLTVAWFVINRVDTTRIEYS 287
Cdd:cd20181    84 LQRMNIYQEVFLSVLYRVLPIQKYLEPVYFYIYTLFGLQAVYVIALYITSWLLSGTWLSGLLAAVWYITNRIDTTRVEFT 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462619102 288 IPLRENWALPYFACQIAALTGYLKSNLNTYGERFCYLLMSASTYTFMMMWEYSHYLLFLQAISLFLLDTFSVEQSDKVYE 367
Cdd:cd20181   164 IPLRENWALPFFAIQIAAITYFLRPNLQPLQERLTLLAIFISTFLFSLTWQFNQFMMLIQALVLFTLDCLDMLPTAKVTW 243
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462619102 368 VYKIYIFSLFLGYLLQFENPALLVSPLLSLVAALMLAK--------------------------CLQMFVPH-------- 413
Cdd:cd20181   244 LYGIQISGLLLVCILQFFNSMILGSLLLSFNLSVLIVRklqknlktgsflnrlgklllhlalvlCLTLFLNNiikkilnl 323
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462619102 414 KENGHMLKFLEVKFGLNMTKNFTMNWLLCQESLQAPSQDFFLRLTQSSLLPFYILVLIICFLSMLQVIFRRINGK-SLKE 492
Cdd:cd20181   324 KSDEHIFKFLKAKFGFGATRDFDANLYLCEEAFGLLPFNTFERLSDTLLFYAYIFVLLLTVIVAAVVAFHNLSDStNQQS 403
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462619102 493 TVTLEDGRIGERPEIIYHVIHTILLGSLAMVIEGLKYIWIPYVCMLAAFGVCSPELWMTLFKWLRLRTVHPIllaLILSM 572
Cdd:cd20181   404 MGKMEKGTVDLKPEVAYNLIHTILFGFLALSTMRMKYLWTSHMCVFASFGLCSTELWELLLKSVHLYNPKRI---RVMRY 480
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462619102 573 AVPTIIGLSLWKEFFPRLMTELMELQEFYDPDTVELMTWIKRQAPVAAVFAGSPQLMGAIKLCTGWMVTSLPLYNDDDLL 652
Cdd:cd20181   481 SVPILTLLYLCYKFWPGLMDELSELREFYDPDTVELMNWINSNTPRKAVFAGSMQLLAGVKLCTGRTLTNHPHYEDKSLR 560
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462619102 653 KRNENIYQIYSKRSAEDIYKILTSYKANYLIVEDAICNEVGPMRGCRVKDLLDIANGHMVCEEGDK---LTYSKYGRFCH 729
Cdd:cd20181   561 ERTRQVYQIYAKRSPEEVHALLRSFGTDYVILEDSICYERRHRRGCRLRDLLDIANGHIMDGPGENdpdLKPADHPRFCE 640
                         650       660
                  ....*....|....*....|....*..
gi 2462619102 730 EVKINYSPYVNYFTRVYWNRSYFVYKI 756
Cdd:cd20181   641 EIKRNLPSYAAYFTRVFQNKTFHVYKL 667
Dpy19L1 cd20178
C-mannosyltransferase Dpy-19-like protein 1 (Dpy19L1); Dpy19 proteins are ...
125-706 1.44e-50

C-mannosyltransferase Dpy-19-like protein 1 (Dpy19L1); Dpy19 proteins are C-mannosyltransferases that mediate C-mannosylation of tryptophan residues on target proteins. C-mannosylation is the attachment of alpha-mannose to the indole C2 carbon of the first tryptophan residue in the consensus amino acid sequence Trp-Xaa-Xaa-Trp/Cys through a C-C bond. This reaction takes place in the endoplasmic reticulum (ER) lumen. Dpy19 is a transmembrane domain family whose name is derived from the Caenorhabditis elegans Dumpy mutant. Dpy19L1 (also called protein Dpy-19 homolog 1) regulates neurite extension during development.


Pssm-ID: 439131  Cd Length: 652  Bit Score: 187.75  E-value: 1.44e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462619102 125 KIFIGCLAAVTSGMMYALYLSAYHERKFWFSNRQELEREITFQGDSAIYYSYYKDMLKAPSFERGVYELTHNNKTVSLKT 204
Cdd:cd20178     1 KIWVTLLLAALAGVLHWSHITHLFENDRHFSHLSTLEREMAFRTEMGLYYSYFKTIIEAPSFLNGVWMIMNDRLTEYPLV 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462619102 205 INAVQQMSLYPELIASILYQA-TGSNEII--------------------------EPVYFYIGIVFGLQGIYVTALFVTS 257
Cdd:cd20178    81 INTLKRFNLYPEVVLASWYRIyTGIMDFFgiqtktcwtvnrgeglspvesceglgDPAYFYVAVIFLLNGLMMSLFFIYG 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462619102 258 WLMSGTWLAGMLTVAWFVINRVDTTRIEYSIPLRENWALPYFACQIAALTGYLKSNlNTYgeRFCYLLMSASTYTFMMMW 337
Cdd:cd20178   161 TYLSGSRLGGVVTVLCFFFNHGECTRVMWTPPLRESFSYPFLVLQMLLVTYILRAP-NLG--RGSLIALCISNVLFMLPW 237
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462619102 338 EYSHYLLFLQAISLFLLDTFSVEQSDKVYEVYKIYIFSLFLGYLLQFENPALLVSPLLSLVAAL-----MLAKCLQMFVP 412
Cdd:cd20178   238 QFAQFVLLTQIASLFAVYVVGYIDSCKLQKILYAHMISLVVCFVLMFGNSMLLTSYYASSLVIIwgilaLRPKFLKVNKS 317
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462619102 413 H----------------------------KENGHMLKFLEVKFglNMTKNFTMNWLLCQESLQAPSQDFFLRLTQSSLLP 464
Cdd:cd20178   318 EvslwviqgcawlfgtvilkyltskvfgiADDAHIGNLLKSKF--TSYKDFDTLMYTCAAEFDFMEKETPLRYTKTLLLP 395
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462619102 465 fyilVLIICFLSMLQVIFRRINGKSLKETVTLEDGRIgERPEIIYHVIHTILLGSLAMVIEGLKYIWIPYVCMLAAFgVC 544
Cdd:cd20178   396 ----VVLVVFAAIARKTIKDLWGVLAKKATHTRKEQF-AHGELVYHALQLLAYAVLAILIMRLKLFLTPHMCVMASL-VC 469
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462619102 545 SPElwmtLFKWLRLRTVHPILLALILsmAVPTIIGLSlwkeffpRLMTELMELQEFYDPDTVELMTWIKRQAPVAAVFAG 624
Cdd:cd20178   470 SRQ----LFGWLFCKVHPQAVVFAIL--AAMAIQGSA-------NLQTQWNIIGEFSNLPQEELLEWIKYNTKPDAVFAG 536
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462619102 625 SPQLMGAIKLCTGWMVTSLPLYNDDDLLKRNENIYQIYSKRSAEDIYKILTSYKANYLIVEDAIC-NEVGPmrGCRVKDL 703
Cdd:cd20178   537 AMPTMASVKLSALRPIVNHPHYEDAGLRARTKIVYSMYSRKPAEEVKRELMKLGVNYYILEESWCvRRSKP--GCSMPEI 614

                  ...
gi 2462619102 704 LDI 706
Cdd:cd20178   615 WDV 617
Dpy19L2 cd20179
C-mannosyltransferase Dpy-19-like protein 2 (Dpy19L2); Dpy19 proteins are ...
133-708 9.79e-48

C-mannosyltransferase Dpy-19-like protein 2 (Dpy19L2); Dpy19 proteins are C-mannosyltransferases that mediate C-mannosylation of tryptophan residues on target proteins. C-mannosylation is the attachment of alpha-mannose to the indole C2 carbon of the first tryptophan residue in the consensus amino acid sequence Trp-Xaa-Xaa-Trp/Cys through a C-C bond. This reaction takes place in the endoplasmic reticulum (ER) lumen. Dpy19 is a transmembrane domain family whose name is derived from the Caenorhabditis elegans Dumpy mutant. Dpy19L2 (also called protein Dpy-19 homolog 2) deletion is a major cause of globozoospermia.


Pssm-ID: 439132  Cd Length: 652  Bit Score: 179.86  E-value: 9.79e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462619102 133 AVTSGMMYALYLSAYHERKFWFSNRQELEREITFQGDSAIYYSYYKDMLKAPSFERGVYELTHNNKTVSLKTINAVQQMS 212
Cdd:cd20179    11 AVFVAILHWLHLVTLFENDRHFSHLSSLEREMTFRTEMGLYYSYFKTIIEAPSFLEGLWMIMNDRLTEYPLIINAIKRFH 90
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462619102 213 LYPELIASILYQATGS---------------------NEII------EPVYFYIGIVFGLQGIYVTALFVTSWLMSGTWL 265
Cdd:cd20179    91 LYPEVIIASWYCTFMGimnlfgletktcwnvtrieplNEVQsceglgDPACFYVGVIFILNGLMMGLFFMYGAYLSGTQL 170
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462619102 266 AGMLTVAWFVINRVDTTRIEYSIPLRENWALPYFACQIAALTGYLKSnlnTYGERFCYLLMSASTYTFMMMWEYSHYLLF 345
Cdd:cd20179   171 GGLITVLCFFFNHGEATRVMWTPPLRESFSYPFLVLQMCILTLILRT---SSNDRRPFIALCLSNVAFMLPWQFAQFILF 247
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462619102 346 LQAISLFLLDTFSVEQSDKVYEVYKIYIFSLFLGYLLQFENP---ALLVSPLLSLVAALMLAKC---------LQMFVPH 413
Cdd:cd20179   248 TQIASLFPMYVVGYIEPSKFQKIIYMNMISVTLSFILMFGNSmylSSYYSSSLLMTWAIILKRNeiqklgvskLNFWLIQ 327
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462619102 414 KE----NGHMLKFLEVKFgLNMTKNFTMNWLLCQESLQ-----------APSQDFF-----LRLTQSSLLPfyiLVLIIC 473
Cdd:cd20179   328 GSawwcGTIILKFLTSKI-LGVSDHIRLSDLIAARILRytdfdtliytcAPEFDFMekatpLRYTKTLLLP---VVMVIT 403
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462619102 474 FLsmlqvIFRRI--NGKSLKETVTLEDGRIGERPEIIYHVIHTILLGSLAMVIEGLKYIWIPYVCMLAAFgVCSPELwmt 551
Cdd:cd20179   404 CF-----IFKKTvrDISYVLATNIYLRKQLLEHSELAFHTLQLLVFTALAILIMRLKMFLTPHMCVMASL-ICSRQL--- 474
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462619102 552 lFKWLRLRTVHPILLALILSMAvpTIIGLSlwkeffpRLMTELMELQEFYDPDTVELMTWIKRQAPVAAVFAGSPQLMGA 631
Cdd:cd20179   475 -FGWLFRRVRFEKVIFGILTVM--SIQGYA-------NLRNQWSIIGEFNNLPQEELLQWIKYSTTSDAVFAGAMPTMAS 544
                         570       580       590       600       610       620       630
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2462619102 632 IKLCTGWMVTSLPLYNDDDLLKRNENIYQIYSKRSAEDIYKILTSYKANYLIVEDAICnEVGPMRGCRVKDLLDIAN 708
Cdd:cd20179   545 IKLSTLHPIVNHPHYEDADLRARTKIVYSTYSRKSAKEVRDKLLELHVNYYVLEEAWC-VVRTKPGCSMLEIWDVED 620
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH