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Conserved domains on  [gi|2462624152|ref|XP_054218687|]
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F-box/WD repeat-containing protein 2 isoform X4 [Homo sapiens]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 10077586)

WD40 repeat domain-containing protein similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 11-318 8.79e-40

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


:

Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 141.32  E-value: 8.79e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624152  11 ETSSLIGHSARVYAL--YYKDGLLCTGSDDLSAKLWDVSTGQCVYGIQTHT-----CAAVKFDEQkLVTGSFDNTVACWE 83
Cdd:cd00200     1 LRRTLKGHTGGVTCVafSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTgpvrdVAASADGTY-LASGSSDKTIRLWD 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624152  84 WSSGARTQHFRGHTGAVFSVDYNDELDILVSGSADFTVKVWALSAGTCLNTLTGHTEWVTKVVLqkckvksllhSPGDYI 163
Cdd:cd00200    80 LETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAF----------SPDGTF 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624152 164 LLSA--DKYeIKIWPIGreiNCKCLKTLSVSED--RSICLQPRLhfdGKYIVCSSALGLYQWDFASYDILRVI--KTPEI 237
Cdd:cd00200   150 VASSsqDGT-IKLWDLR---TGKCVATLTGHTGevNSVAFSPDG---EKLLSSSSDGTIKLWDLSTGKCLGTLrgHENGV 222

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624152 238 ANLALLGFGDIFALLFDNRYLYIMDLRTESLISRwplpeyrkskrgssfLAGEASWLNGLDGHNDTGLVFATSMpDHSIH 317
Cdd:cd00200   223 NSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQT---------------LSGHTNSVTSLAWSPDGKRLASGSA-DGTIR 286


                  .
gi 2462624152 318 L 318
Cdd:cd00200   287 I 287
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 11-318 8.79e-40

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 141.32  E-value: 8.79e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624152  11 ETSSLIGHSARVYAL--YYKDGLLCTGSDDLSAKLWDVSTGQCVYGIQTHT-----CAAVKFDEQkLVTGSFDNTVACWE 83
Cdd:cd00200     1 LRRTLKGHTGGVTCVafSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTgpvrdVAASADGTY-LASGSSDKTIRLWD 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624152  84 WSSGARTQHFRGHTGAVFSVDYNDELDILVSGSADFTVKVWALSAGTCLNTLTGHTEWVTKVVLqkckvksllhSPGDYI 163
Cdd:cd00200    80 LETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAF----------SPDGTF 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624152 164 LLSA--DKYeIKIWPIGreiNCKCLKTLSVSED--RSICLQPRLhfdGKYIVCSSALGLYQWDFASYDILRVI--KTPEI 237
Cdd:cd00200   150 VASSsqDGT-IKLWDLR---TGKCVATLTGHTGevNSVAFSPDG---EKLLSSSSDGTIKLWDLSTGKCLGTLrgHENGV 222

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624152 238 ANLALLGFGDIFALLFDNRYLYIMDLRTESLISRwplpeyrkskrgssfLAGEASWLNGLDGHNDTGLVFATSMpDHSIH 317
Cdd:cd00200   223 NSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQT---------------LSGHTNSVTSLAWSPDGKRLASGSA-DGTIR 286


                  .
gi 2462624152 318 L 318
Cdd:cd00200   287 I 287
WD40 COG2319
WD40 repeat [General function prediction only];
11-318 5.49e-33

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 125.79  E-value: 5.49e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624152  11 ETSSLIGHSARVYALYY-KDG-LLCTGSDDLSAKLWDVSTGQCVYGIQTHTCA--AVKF--DEQKLVTGSFDNTVACWEW 84
Cdd:COG2319   112 LLRTLTGHTGAVRSVAFsPDGkTLASGSADGTVRLWDLATGKLLRTLTGHSGAvtSVAFspDGKLLASGSDDGTVRLWDL 191

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624152  85 SSGARTQHFRGHTGAVFSVDYNDELDILVSGSADFTVKVWALSAGTCLNTLTGHTEWVTKVVLqkckvksllhSPGDYIL 164
Cdd:COG2319   192 ATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAF----------SPDGRLL 261

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624152 165 LSADKY-EIKIWPIGREincKCLKTLSVSEDRSICLqpRLHFDGKYIVCSSALG-LYQWDFASYDILRVIK--TPEIANL 240
Cdd:COG2319   262 ASGSADgTVRLWDLATG---ELLRTLTGHSGGVNSV--AFSPDGKLLASGSDDGtVRLWDLATGKLLRTLTghTGAVRSV 336

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2462624152 241 ALLGFGDIFALLFDNRYLYIMDLRTESLISRwplpeyrkskrgssfLAGEASWLNGLDGHNDtGLVFATSMPDHSIHL 318
Cdd:COG2319   337 AFSPDGKTLASGSDDGTVRLWDLATGELLRT---------------LTGHTGAVTSVAFSPD-GRTLASGSADGTVRL 398
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 18-139 4.21e-07

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 51.63  E-value: 4.21e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624152  18 HSARVYALYYKDG---LLCTGSDDLSAKLWDVSTGQCVYGIQTH-TCAAVKFDE---QKLVTGSFDNTVACWEWSSGART 90
Cdd:PLN00181  574 HEKRVWSIDYSSAdptLLASGSDDGSVKLWSINQGVSIGTIKTKaNICCVQFPSesgRSLAFGSADHKVYYYDLRNPKLP 653

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2462624152  91 Q-HFRGHTGAVFSVDYNDElDILVSGSADFTVKVWALSAG------TCLNTLTGHT 139
Cdd:PLN00181  654 LcTMIGHSKTVSYVRFVDS-STLVSSSTDNTLKLWDLSMSisgineTPLHSFMGHT 708
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 86-124 4.36e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.07  E-value: 4.36e-06
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 2462624152   86 SGARTQHFRGHTGAVFSVDYNDELDILVSGSADFTVKVW 124
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
87-124 1.48e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.56  E-value: 1.48e-05
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 2462624152  87 GARTQHFRGHTGAVFSVDYNDELDILVSGSADFTVKVW 124
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 11-318 8.79e-40

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 141.32  E-value: 8.79e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624152  11 ETSSLIGHSARVYAL--YYKDGLLCTGSDDLSAKLWDVSTGQCVYGIQTHT-----CAAVKFDEQkLVTGSFDNTVACWE 83
Cdd:cd00200     1 LRRTLKGHTGGVTCVafSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTgpvrdVAASADGTY-LASGSSDKTIRLWD 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624152  84 WSSGARTQHFRGHTGAVFSVDYNDELDILVSGSADFTVKVWALSAGTCLNTLTGHTEWVTKVVLqkckvksllhSPGDYI 163
Cdd:cd00200    80 LETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAF----------SPDGTF 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624152 164 LLSA--DKYeIKIWPIGreiNCKCLKTLSVSED--RSICLQPRLhfdGKYIVCSSALGLYQWDFASYDILRVI--KTPEI 237
Cdd:cd00200   150 VASSsqDGT-IKLWDLR---TGKCVATLTGHTGevNSVAFSPDG---EKLLSSSSDGTIKLWDLSTGKCLGTLrgHENGV 222

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624152 238 ANLALLGFGDIFALLFDNRYLYIMDLRTESLISRwplpeyrkskrgssfLAGEASWLNGLDGHNDTGLVFATSMpDHSIH 317
Cdd:cd00200   223 NSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQT---------------LSGHTNSVTSLAWSPDGKRLASGSA-DGTIR 286


                  .
gi 2462624152 318 L 318
Cdd:cd00200   287 I 287
WD40 COG2319
WD40 repeat [General function prediction only];
11-318 5.49e-33

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 125.79  E-value: 5.49e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624152  11 ETSSLIGHSARVYALYY-KDG-LLCTGSDDLSAKLWDVSTGQCVYGIQTHTCA--AVKF--DEQKLVTGSFDNTVACWEW 84
Cdd:COG2319   112 LLRTLTGHTGAVRSVAFsPDGkTLASGSADGTVRLWDLATGKLLRTLTGHSGAvtSVAFspDGKLLASGSDDGTVRLWDL 191

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624152  85 SSGARTQHFRGHTGAVFSVDYNDELDILVSGSADFTVKVWALSAGTCLNTLTGHTEWVTKVVLqkckvksllhSPGDYIL 164
Cdd:COG2319   192 ATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAF----------SPDGRLL 261

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624152 165 LSADKY-EIKIWPIGREincKCLKTLSVSEDRSICLqpRLHFDGKYIVCSSALG-LYQWDFASYDILRVIK--TPEIANL 240
Cdd:COG2319   262 ASGSADgTVRLWDLATG---ELLRTLTGHSGGVNSV--AFSPDGKLLASGSDDGtVRLWDLATGKLLRTLTghTGAVRSV 336

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2462624152 241 ALLGFGDIFALLFDNRYLYIMDLRTESLISRwplpeyrkskrgssfLAGEASWLNGLDGHNDtGLVFATSMPDHSIHL 318
Cdd:COG2319   337 AFSPDGKTLASGSDDGTVRLWDLATGELLRT---------------LTGHTGAVTSVAFSPD-GRTLASGSADGTVRL 398
WD40 COG2319
WD40 repeat [General function prediction only];
14-273 6.31e-31

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 120.40  E-value: 6.31e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624152  14 SLIGHSARVYALYYK--DGLLCTGSDDLSAKLWDVSTGQCVYGIQTHTCA--AVKF--DEQKLVTGSFDNTVACWEWSSG 87
Cdd:COG2319    73 TLLGHTAAVLSVAFSpdGRLLASASADGTVRLWDLATGLLLRTLTGHTGAvrSVAFspDGKTLASGSADGTVRLWDLATG 152

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624152  88 ARTQHFRGHTGAVFSVDYNDELDILVSGSADFTVKVWALSAGTCLNTLTGHTEWVTKVVLqkckvksllhSP-GDYILLS 166
Cdd:COG2319   153 KLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAF----------SPdGKLLASG 222

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624152 167 ADKYEIKIWPIGREincKCLKTLSVSED--RSICLQPrlhfDGKYIVCSSALG-LYQWDFASYDILRVIKTPE--IANLA 241
Cdd:COG2319   223 SADGTVRLWDLATG---KLLRTLTGHSGsvRSVAFSP----DGRLLASGSADGtVRLWDLATGELLRTLTGHSggVNSVA 295

                         250       260       270
                  ....*....|....*....|....*....|..
gi 2462624152 242 LLGFGDIFALLFDNRYLYIMDLRTESLISRWP 273
Cdd:COG2319   296 FSPDGKLLASGSDDGTVRLWDLATGKLLRTLT 327
WD40 COG2319
WD40 repeat [General function prediction only];
14-177 1.83e-29

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 116.16  E-value: 1.83e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624152  14 SLIGHSARVYALYY-KDG-LLCTGSDDLSAKLWDVSTGQCVYGIQTHTCA--AVKF--DEQKLVTGSFDNTVACWEWSSG 87
Cdd:COG2319   241 TLTGHSGSVRSVAFsPDGrLLASGSADGTVRLWDLATGELLRTLTGHSGGvnSVAFspDGKLLASGSDDGTVRLWDLATG 320

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624152  88 ARTQHFRGHTGAVFSVDYNDELDILVSGSADFTVKVWALSAGTCLNTLTGHTEWVTKVVLqkckvksllhSP-GDYILLS 166
Cdd:COG2319   321 KLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAF----------SPdGRTLASG 390

                         170
                  ....*....|.
gi 2462624152 167 ADKYEIKIWPI 177
Cdd:COG2319   391 SADGTVRLWDL 401
WD40 COG2319
WD40 repeat [General function prediction only];
29-318 9.67e-24

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 100.37  E-value: 9.67e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624152  29 DGLLCTGSDDLSAKLWDVSTGQCVYGIQTHT----CAAVKFDEQKLVTGSFDNTVACWEWSSGARTQHFRGHTGAVFSVD 104
Cdd:COG2319    48 GARLAAGAGDLTLLLLDAAAGALLATLLGHTaavlSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVA 127

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624152 105 YNDELDILVSGSADFTVKVWALSAGTCLNTLTGHTEWVTKVVLqkckvksllhSP-GDYILLSADKYEIKIWPIGreiNC 183
Cdd:COG2319   128 FSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAF----------SPdGKLLASGSDDGTVRLWDLA---TG 194

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624152 184 KCLKTLSVSED--RSICLQPrlhfDGKYIVCSSALG-LYQWDFASYDILRVIK--TPEIANLALLGFGDIFALLFDNRYL 258
Cdd:COG2319   195 KLLRTLTGHTGavRSVAFSP----DGKLLASGSADGtVRLWDLATGKLLRTLTghSGSVRSVAFSPDGRLLASGSADGTV 270

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624152 259 YIMDLRTESLISRwplpeyrkskrgssfLAGEASWLNGLDGHNDtGLVFATSMPDHSIHL 318
Cdd:COG2319   271 RLWDLATGELLRT---------------LTGHSGGVNSVAFSPD-GKLLASGSDDGTVRL 314
WD40 COG2319
WD40 repeat [General function prediction only];
14-127 7.44e-23

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 97.67  E-value: 7.44e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624152  14 SLIGHSARVYALYY-KDG-LLCTGSDDLSAKLWDVSTGQCVYGIQTHT----CAAVKFDEQKLVTGSFDNTVACWEWSSG 87
Cdd:COG2319   283 TLTGHSGGVNSVAFsPDGkLLASGSDDGTVRLWDLATGKLLRTLTGHTgavrSVAFSPDGKTLASGSDDGTVRLWDLATG 362

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 2462624152  88 ARTQHFRGHTGAVFSVDYNDELDILVSGSADFTVKVWALS 127
Cdd:COG2319   363 ELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 COG2319
WD40 repeat [General function prediction only];
34-318 1.48e-15

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 76.87  E-value: 1.48e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624152  34 TGSDDLSAKLWDVSTGQCVYGIQTHT----CAAVKFDEQKLVTGSFDNTVACWEWSSGARTQHFRGHTGAVFSVDYNDEL 109
Cdd:COG2319    11 AASADLALALLAAALGALLLLLLGLAaavaSLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDG 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624152 110 DILVSGSADFTVKVWALSAGTCLNTLTGHTEWVTKVVLqkckvksllhSP-GDYILLSADKYEIKIWPIGREincKCLKT 188
Cdd:COG2319    91 RLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAF----------SPdGKTLASGSADGTVRLWDLATG---KLLRT 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624152 189 LSVSED--RSICLQPrlhfDGKYIVCSSALG-LYQWDFASYDILRVIK--TPEIANLALLGFGDIFALLFDNRYLYIMDL 263
Cdd:COG2319   158 LTGHSGavTSVAFSP----DGKLLASGSDDGtVRLWDLATGKLLRTLTghTGAVRSVAFSPDGKLLASGSADGTVRLWDL 233

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2462624152 264 RTESLISRwplpeyrkskrgssfLAGEASWLNGL----DGHndtglVFATSMPDHSIHL 318
Cdd:COG2319   234 ATGKLLRT---------------LTGHSGSVRSVafspDGR-----LLASGSADGTVRL 272
WD40 COG2319
WD40 repeat [General function prediction only];
14-86 1.40e-08

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 55.69  E-value: 1.40e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2462624152  14 SLIGHSARVYAL-YYKDG-LLCTGSDDLSAKLWDVSTGQCVYGIQTHTCA--AVKF--DEQKLVTGSFDNTVACWEWSS 86
Cdd:COG2319   325 TLTGHTGAVRSVaFSPDGkTLASGSDDGTVRLWDLATGELLRTLTGHTGAvtSVAFspDGRTLASGSADGTVRLWDLAT 403
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 18-139 4.21e-07

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 51.63  E-value: 4.21e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624152  18 HSARVYALYYKDG---LLCTGSDDLSAKLWDVSTGQCVYGIQTH-TCAAVKFDE---QKLVTGSFDNTVACWEWSSGART 90
Cdd:PLN00181  574 HEKRVWSIDYSSAdptLLASGSDDGSVKLWSINQGVSIGTIKTKaNICCVQFPSesgRSLAFGSADHKVYYYDLRNPKLP 653

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2462624152  91 Q-HFRGHTGAVFSVDYNDElDILVSGSADFTVKVWALSAG------TCLNTLTGHT 139
Cdd:PLN00181  654 LcTMIGHSKTVSYVRFVDS-STLVSSSTDNTLKLWDLSMSisgineTPLHSFMGHT 708
PTZ00421 PTZ00421
coronin; Provisional
 65-143 1.14e-06

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 49.89  E-value: 1.14e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624152  65 FDEQKLVTGSFDNTVACWEWSSGARTQ-------HFRGHTGAVFSVDYN-DELDILVSGSADFTVKVWALSAGTCLNTLT 136
Cdd:PTZ00421   86 FDPQKLFTASEDGTIMGWGIPEEGLTQnisdpivHLQGHTKKVGIVSFHpSAMNVLASAGADMVVNVWDVERGKAVEVIK 165


                  ....*..
gi 2462624152 137 GHTEWVT 143
Cdd:PTZ00421  166 CHSDQIT 172
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 86-124 4.36e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.07  E-value: 4.36e-06
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 2462624152   86 SGARTQHFRGHTGAVFSVDYNDELDILVSGSADFTVKVW 124
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
87-124 1.48e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.56  E-value: 1.48e-05
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 2462624152  87 GARTQHFRGHTGAVFSVDYNDELDILVSGSADFTVKVW 124
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
NBCH_WD40 pfam20426
Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at ...
 31-132 1.74e-05

Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at the C-terminus of neurobeachin-like proteins.


Pssm-ID: 466575 [Multi-domain]  Cd Length: 350  Bit Score: 45.83  E-value: 1.74e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624152  31 LLCTGSDDLSAKLWDVSTGQCVYGIQTH----TCAAVKFDEQKLVTGSFDNTVACWEWSSG---------ARTQHFR--- 94
Cdd:pfam20426  96 LISCGNWENSFQVISLNDGRMVQSIRQHkdvvSCVAVTSDGSILATGSYDTTVMVWEVLRGrssekrsrnTQTEFPRkdh 175

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 2462624152  95 -----------GHTGAVFSVDYNDELDILVSGSADftvkvwalsaGTCL 132
Cdd:pfam20426 176 viaetpfhilcGHDDIITCLYVSVELDIVISGSKD----------GTCI 214
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 67-135 8.17e-04

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 41.23  E-value: 8.17e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624152  67 EQKLVTGSFDNTVACWEWSSGARTQHFRGHTGAVFSVDYND-ELDILVSGSADFTVKVWALSAGTCLNTL 135
Cdd:PLN00181  545 KSQVASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSaDPTLLASGSDDGSVKLWSINQGVSIGTI 614
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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