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Conserved domains on  [gi|2462517825|ref|XP_054221173|]
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ankyrin repeat domain-containing protein 26 isoform X14 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CCDC144C pfam14915
CCDC144C protein coiled-coil region; This family includes the human protein CCDC144C and the ...
 1275-1578 8.22e-166

CCDC144C protein coiled-coil region; This family includes the human protein CCDC144C and the ankyrin repeat domain-containing protein 26-like 1 found in eukaryotes. Its function remains unknown, however, it is known to contain a coiled-coil domain which corresponds to this region. The ankyrin repeat which features in this protein is a common amino acid motif.


:

Pssm-ID: 464371 [Multi-domain]  Cd Length: 304  Bit Score: 509.91  E-value: 8.22e-166
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1275 NSMLQEEIAMLRLEIDTIKNQNQEKEKKCFEDLKIVKEKNEDLQKTIKQNEETLTQTISQYNGRLSVLTAENAMLNSKLE 1354
Cdd:pfam14915    1 NCMLQDEIAMLRLEIDTIKNQNQEKEKKYLEDIEILKEKNDDLQKTLKLNEETLTKTVFQYNGQLNVLKAENTMLNSKLE 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1355 NEKQSKERLEAEVESYHSRLAAAIHDRDQSETSKRELELAFQRARDECSRLQDKMNFDVSNLKDNNEILSQQLFKTESKL 1434
Cdd:pfam14915   81 NEKQNKERLETEVESYRSRLAAAIQDHEQSQTSKRDLELAFQRERDEWLRLQDKMNFDVSNLRDENEILSQQLSKAESKA 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1435 NSLEIEFHHTRDALREKTLGLERVQKDLSQTQCQMKEMEQKYQNEQVKVNKYIGKQESVEERLSQLQSENMLLRQQLDDA 1514
Cdd:pfam14915  161 NSLENELHRTRDALREKTLLLESVQRDLSQAQCQKKELEHMYQNEQDKVNKYIGKQESLEERLAQLQSENMLLRQQLEDA 240

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2462517825 1515 HNKADNKEKTVINIQDQFHAIVQKLQAESEKQSLLLEERNKELISECNHLKERQYQYENEKAER 1578
Cdd:pfam14915  241 QNKADAKEKTVIDIQDQFQDIVKKLQAESEKQVLLLEERNKELINECNHLKERLYQYEKEKAER 304
DUF3496 pfam12001
Domain of unknown function (DUF3496); This presumed domain is functionally uncharacterized. ...
 1884-1992 2.11e-57

Domain of unknown function (DUF3496); This presumed domain is functionally uncharacterized. This domain is found in eukaryotes. This domain is about 110 amino acids in length.


:

Pssm-ID: 463425 [Multi-domain]  Cd Length: 109  Bit Score: 193.73  E-value: 2.11e-57
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1884 KSQMELRIKDLESELSKIKTSQEDFNKTELEKYKQLYLEELKVRKSLSSKLTKTNERLAEVNTKLLVEKQQSRSLFTTLT 1963
Cdd:pfam12001    1 RSQMELRIKDLESELSKMKTSQEDSNKIELEKYKQLYLEELKVRKSLSNKLNKTNERLAEVSTKLLVEKQQNRSLLSTLT 80

                           90       100
                   ....*....|....*....|....*....
gi 2462517825 1964 TRPVMEPPCVGNLNNSLDLNRKLIPRENL 1992
Cdd:pfam12001   81 TRPVLESPCVGNLNNSLVLNRNFIPRENL 109
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
44-210 6.52e-39

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 147.79  E-value: 6.52e-39
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825   44 DRDLGKIHKAASAGNVAKVQQILLLRKNGLNDRDKMNRTALHLACANGHPEVVTLLVDRKCQLNVCDNENRTALMKAVQC 123
Cdd:COG0666     51 DALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYN 130

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825  124 QEEKCATILLEHGADPNLADVHGNTALHYAVYNEDISVATKLLLYDANIEAKNKDDLTPLLLAVSGKKQQMVEFLIKKKA 203
Cdd:COG0666    131 GNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGA 210


                   ....*..
gi 2462517825  204 NVNAVDK 210
Cdd:COG0666    211 DVNAKDN 217
SMC_prok_B super family cl37069
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 1108-1775 7.52e-21

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


The actual alignment was detected with superfamily member TIGR02168:

Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 100.52  E-value: 7.52e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1108 ELLTVKIKKMEDKVNVLQRELSETKEIKSQLEHQKVEWERELCSLRFSL-----------NQEEEKRRNADTLYEKI--- 1173
Cdd:TIGR02168  270 EELRLEVSELEEEIEELQKELYALANEISRLEQQKQILRERLANLERQLeeleaqleeleSKLDELAEELAELEEKLeel 349

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1174 REQLRRKEEQYRKEVEVKQQLELSLQTLEMELRTVKSNLNQVVQERNDAQRQLSR-----EQNARMLQ--DGILTNHLSK 1246
Cdd:TIGR02168  350 KEELESLEAELEELEAELEELESRLEELEEQLETLRSKVAQLELQIASLNNEIERlearlERLEDRRErlQQEIEELLKK 429

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1247 QKEIEMAQKKMNSENSHSHEEEKDLSHKN-----SMLQEEIAMLRLEIDTIKNQNQEKEKKCfEDLKIVKEKNEDLQKTI 1321
Cdd:TIGR02168  430 LEEAELKELQAELEELEEELEELQEELERleealEELREELEEAEQALDAAERELAQLQARL-DSLERLQENLEGFSEGV 508

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1322 KQNEETLTQtISQYNGRLSVL--------TAENAMLNSKL-----ENEKQSKERLEAEVESYHSRLAAAIHDR------D 1382
Cdd:TIGR02168  509 KALLKNQSG-LSGILGVLSELisvdegyeAAIEAALGGRLqavvvENLNAAKKAIAFLKQNELGRVTFLPLDSikgteiQ 587

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1383 QSETSKRELELAFQRARDEC----SRLQDKMNF------DVSNLKDNNEILSQQLFktESKLNSLEIEFHHTRDAL---- 1448
Cdd:TIGR02168  588 GNDREILKNIEGFLGVAKDLvkfdPKLRKALSYllggvlVVDDLDNALELAKKLRP--GYRIVTLDGDLVRPGGVItggs 665

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1449 REKTLGLERVQKDLSQTQCQMKEMEQKYQNEQVKVNKYIGKQESVEERLSQLQSENMLLRQQLDDAHNKADNKEKTVINI 1528
Cdd:TIGR02168  666 AKTNSSILERRREIEELEEKIEELEEKIAELEKALAELRKELEELEEELEQLRKELEELSRQISALRKDLARLEAEVEQL 745

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1529 QDQfhaiVQKLQAESEKQSLLLEERNKELISECNHLKERqyqyENEKAEREVVVRQLQQELadtlkkQSMSEASLEVTSR 1608
Cdd:TIGR02168  746 EER----IAQLSKELTELEAEIEELEERLEEAEEELAEA----EAEIEELEAQIEQLKEEL------KALREALDELRAE 811

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1609 YRiNLEDETQDLKKKLGQIRNQLQEAQDRHTEAVRCAEKMQDHKQKLEKDNAKLKVTVKKQMDKIEELQK---------- 1678
Cdd:TIGR02168  812 LT-LLNEEAANLRERLESLERRIAATERRLEDLEEQIEELSEDIESLAAEIEELEELIEELESELEALLNerasleeala 890

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1679 --NLLNANLSEDEKEQLKKLMELKQslecNLDQEMKKNVELEREITGFKNLLKMTRKKLNEYENGEFsfhGDLKTSQFEM 1756
Cdd:TIGR02168  891 llRSELEELSEELRELESKRSELRR----ELEELREKLAQLELRLEGLEVRIDNLQERLSEEYSLTL---EEAEALENKI 963

                          730
                   ....*....|....*....
gi 2462517825 1757 DIQINKLKHKIDDLTAELE 1775
Cdd:TIGR02168  964 EDDEEEARRRLKRLENKIK 982
DR0291 super family cl34310
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 1755-1928 6.50e-06

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


The actual alignment was detected with superfamily member COG1579:

Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 49.54  E-value: 6.50e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1755 EMDIQINKLKHKIDDLTAELEtagskclHLDTKNQILQEELlsmKTVQKKCEKLQKNKKKLEQEVINLRSHIERNMVELG 1834
Cdd:COG1579     14 ELDSELDRLEHRLKELPAELA-------ELEDELAALEARL---EAAKTELEDLEKEIKRLELEIEEVEARIKKYEEQLG 83

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1835 QVKQYKQ------EIE--ERARQEIAEKLKEVNLFLQAQAASQENLEQF---RENNFASMKSQMELRIKDLESELSKIKT 1903
Cdd:COG1579     84 NVRNNKEyealqkEIEslKRRISDLEDEILELMERIEELEEELAELEAElaeLEAELEEKKAELDEELAELEAELEELEA 163

                          170       180
                   ....*....|....*....|....*
gi 2462517825 1904 SQEDFNKTELEKYKQLYlEELKVRK 1928
Cdd:COG1579    164 EREELAAKIPPELLALY-ERIRKRK 187
 
Name Accession Description Interval E-value
CCDC144C pfam14915
CCDC144C protein coiled-coil region; This family includes the human protein CCDC144C and the ...
 1275-1578 8.22e-166

CCDC144C protein coiled-coil region; This family includes the human protein CCDC144C and the ankyrin repeat domain-containing protein 26-like 1 found in eukaryotes. Its function remains unknown, however, it is known to contain a coiled-coil domain which corresponds to this region. The ankyrin repeat which features in this protein is a common amino acid motif.


Pssm-ID: 464371 [Multi-domain]  Cd Length: 304  Bit Score: 509.91  E-value: 8.22e-166
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1275 NSMLQEEIAMLRLEIDTIKNQNQEKEKKCFEDLKIVKEKNEDLQKTIKQNEETLTQTISQYNGRLSVLTAENAMLNSKLE 1354
Cdd:pfam14915    1 NCMLQDEIAMLRLEIDTIKNQNQEKEKKYLEDIEILKEKNDDLQKTLKLNEETLTKTVFQYNGQLNVLKAENTMLNSKLE 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1355 NEKQSKERLEAEVESYHSRLAAAIHDRDQSETSKRELELAFQRARDECSRLQDKMNFDVSNLKDNNEILSQQLFKTESKL 1434
Cdd:pfam14915   81 NEKQNKERLETEVESYRSRLAAAIQDHEQSQTSKRDLELAFQRERDEWLRLQDKMNFDVSNLRDENEILSQQLSKAESKA 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1435 NSLEIEFHHTRDALREKTLGLERVQKDLSQTQCQMKEMEQKYQNEQVKVNKYIGKQESVEERLSQLQSENMLLRQQLDDA 1514
Cdd:pfam14915  161 NSLENELHRTRDALREKTLLLESVQRDLSQAQCQKKELEHMYQNEQDKVNKYIGKQESLEERLAQLQSENMLLRQQLEDA 240

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2462517825 1515 HNKADNKEKTVINIQDQFHAIVQKLQAESEKQSLLLEERNKELISECNHLKERQYQYENEKAER 1578
Cdd:pfam14915  241 QNKADAKEKTVIDIQDQFQDIVKKLQAESEKQVLLLEERNKELINECNHLKERLYQYEKEKAER 304
DUF3496 pfam12001
Domain of unknown function (DUF3496); This presumed domain is functionally uncharacterized. ...
 1884-1992 2.11e-57

Domain of unknown function (DUF3496); This presumed domain is functionally uncharacterized. This domain is found in eukaryotes. This domain is about 110 amino acids in length.


Pssm-ID: 463425 [Multi-domain]  Cd Length: 109  Bit Score: 193.73  E-value: 2.11e-57
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1884 KSQMELRIKDLESELSKIKTSQEDFNKTELEKYKQLYLEELKVRKSLSSKLTKTNERLAEVNTKLLVEKQQSRSLFTTLT 1963
Cdd:pfam12001    1 RSQMELRIKDLESELSKMKTSQEDSNKIELEKYKQLYLEELKVRKSLSNKLNKTNERLAEVSTKLLVEKQQNRSLLSTLT 80

                           90       100
                   ....*....|....*....|....*....
gi 2462517825 1964 TRPVMEPPCVGNLNNSLDLNRKLIPRENL 1992
Cdd:pfam12001   81 TRPVLESPCVGNLNNSLVLNRNFIPRENL 109
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
44-210 6.52e-39

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 147.79  E-value: 6.52e-39
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825   44 DRDLGKIHKAASAGNVAKVQQILLLRKNGLNDRDKMNRTALHLACANGHPEVVTLLVDRKCQLNVCDNENRTALMKAVQC 123
Cdd:COG0666     51 DALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYN 130

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825  124 QEEKCATILLEHGADPNLADVHGNTALHYAVYNEDISVATKLLLYDANIEAKNKDDLTPLLLAVSGKKQQMVEFLIKKKA 203
Cdd:COG0666    131 GNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGA 210


                   ....*..
gi 2462517825  204 NVNAVDK 210
Cdd:COG0666    211 DVNAKDN 217
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 1108-1775 7.52e-21

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 100.52  E-value: 7.52e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1108 ELLTVKIKKMEDKVNVLQRELSETKEIKSQLEHQKVEWERELCSLRFSL-----------NQEEEKRRNADTLYEKI--- 1173
Cdd:TIGR02168  270 EELRLEVSELEEEIEELQKELYALANEISRLEQQKQILRERLANLERQLeeleaqleeleSKLDELAEELAELEEKLeel 349

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1174 REQLRRKEEQYRKEVEVKQQLELSLQTLEMELRTVKSNLNQVVQERNDAQRQLSR-----EQNARMLQ--DGILTNHLSK 1246
Cdd:TIGR02168  350 KEELESLEAELEELEAELEELESRLEELEEQLETLRSKVAQLELQIASLNNEIERlearlERLEDRRErlQQEIEELLKK 429

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1247 QKEIEMAQKKMNSENSHSHEEEKDLSHKN-----SMLQEEIAMLRLEIDTIKNQNQEKEKKCfEDLKIVKEKNEDLQKTI 1321
Cdd:TIGR02168  430 LEEAELKELQAELEELEEELEELQEELERleealEELREELEEAEQALDAAERELAQLQARL-DSLERLQENLEGFSEGV 508

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1322 KQNEETLTQtISQYNGRLSVL--------TAENAMLNSKL-----ENEKQSKERLEAEVESYHSRLAAAIHDR------D 1382
Cdd:TIGR02168  509 KALLKNQSG-LSGILGVLSELisvdegyeAAIEAALGGRLqavvvENLNAAKKAIAFLKQNELGRVTFLPLDSikgteiQ 587

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1383 QSETSKRELELAFQRARDEC----SRLQDKMNF------DVSNLKDNNEILSQQLFktESKLNSLEIEFHHTRDAL---- 1448
Cdd:TIGR02168  588 GNDREILKNIEGFLGVAKDLvkfdPKLRKALSYllggvlVVDDLDNALELAKKLRP--GYRIVTLDGDLVRPGGVItggs 665

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1449 REKTLGLERVQKDLSQTQCQMKEMEQKYQNEQVKVNKYIGKQESVEERLSQLQSENMLLRQQLDDAHNKADNKEKTVINI 1528
Cdd:TIGR02168  666 AKTNSSILERRREIEELEEKIEELEEKIAELEKALAELRKELEELEEELEQLRKELEELSRQISALRKDLARLEAEVEQL 745

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1529 QDQfhaiVQKLQAESEKQSLLLEERNKELISECNHLKERqyqyENEKAEREVVVRQLQQELadtlkkQSMSEASLEVTSR 1608
Cdd:TIGR02168  746 EER----IAQLSKELTELEAEIEELEERLEEAEEELAEA----EAEIEELEAQIEQLKEEL------KALREALDELRAE 811

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1609 YRiNLEDETQDLKKKLGQIRNQLQEAQDRHTEAVRCAEKMQDHKQKLEKDNAKLKVTVKKQMDKIEELQK---------- 1678
Cdd:TIGR02168  812 LT-LLNEEAANLRERLESLERRIAATERRLEDLEEQIEELSEDIESLAAEIEELEELIEELESELEALLNerasleeala 890

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1679 --NLLNANLSEDEKEQLKKLMELKQslecNLDQEMKKNVELEREITGFKNLLKMTRKKLNEYENGEFsfhGDLKTSQFEM 1756
Cdd:TIGR02168  891 llRSELEELSEELRELESKRSELRR----ELEELREKLAQLELRLEGLEVRIDNLQERLSEEYSLTL---EEAEALENKI 963

                          730
                   ....*....|....*....
gi 2462517825 1757 DIQINKLKHKIDDLTAELE 1775
Cdd:TIGR02168  964 EDDEEEARRRLKRLENKIK 982
Ank_2 pfam12796
Ankyrin repeats (3 copies);
84-176 1.58e-20

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 87.86  E-value: 1.58e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825   84 LHLACANGHPEVVTLLVDRKCQLNVCDNENRTALMKAVQCQEEKCATILLEHgADPNLADvHGNTALHYAVYNEDISVAT 163
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKD-NGRTALHYAARSGHLEIVK 78

                           90
                   ....*....|...
gi 2462517825  164 KLLLYDANIEAKN 176
Cdd:pfam12796   79 LLLEKGADINVKD 91
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
 1086-1958 3.55e-15

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 82.15  E-value: 3.55e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1086 LLKIQDAALSCERLL-ELKKNHCELLTVKiKKMEDKVNVLQRELSETKEIKSQLEHQKVEWERELCSLRFSLNQEEEKRR 1164
Cdd:pfam01576   14 LQKVKERQQKAESELkELEKKHQQLCEEK-NALQEQLQAETELCAEAEEMRARLAARKQELEEILHELESRLEEEEERSQ 92

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1165 NADTLYEKIREQLRRKEEQYRKEVEVKQQLELSLQTLEMELRTVKSNLNQVvqerNDAQRQLSREQNARMLQDGILTNHL 1244
Cdd:pfam01576   93 QLQNEKKKMQQHIQDLEEQLDEEEAARQKLQLEKVTTEAKIKKLEEDILLL----EDQNSKLSKERKLLEERISEFTSNL 168

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1245 SKQKE---------------IEMAQKKMNSENSHSHEEEK---DLSHKNSMLQEEIAMLRLEIDTIKNQNQEKEkkcfed 1306
Cdd:pfam01576  169 AEEEEkakslsklknkheamISDLEERLKKEEKGRQELEKakrKLEGESTDLQEQIAELQAQIAELRAQLAKKE------ 242

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1307 lkivkeknEDLQKTIKQNEETLTQTiSQYNGRLSVLTAENAMLNSKLENEKQSKER-------LEAEVESYHSRLAAAIH 1379
Cdd:pfam01576  243 --------EELQAALARLEEETAQK-NNALKKIRELEAQISELQEDLESERAARNKaekqrrdLGEELEALKTELEDTLD 313

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1380 DR--DQSETSKRELELA-FQRARDECSRLQDKMNFDVSNLKDNN-EILSQQLFKTESKLNSLEiefhHTRDALREKTLGL 1455
Cdd:pfam01576  314 TTaaQQELRSKREQEVTeLKKALEEETRSHEAQLQEMRQKHTQAlEELTEQLEQAKRNKANLE----KAKQALESENAEL 389

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1456 ERVQKDLSQ----TQCQMKEMEQKYQNEQVKVNKYIGKQESVEERLSQLQSENMLLRQQLDDAHNKADNKEKTVINIQDQ 1531
Cdd:pfam01576  390 QAELRTLQQakqdSEHKRKKLEGQLQELQARLSESERQRAELAEKLSKLQSELESVSSLLNEAEGKNIKLSKDVSSLESQ 469

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1532 FHAiVQKLQAESEKQSLLLEERNKELISECNHLKERQYQYENEKAEREVVVRQLQQELADTLKKQ----SMSEASLEVTS 1607
Cdd:pfam01576  470 LQD-TQELLQEETRQKLNLSTRLRQLEDERNSLQEQLEEEEEAKRNVERQLSTLQAQLSDMKKKLeedaGTLEALEEGKK 548

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1608 RYRINLEDETQDLKKK------LGQIRNQLQE-------AQDRHTEAVRCAEKMQDHKQKLEKDNAKLKVTVKKQMDKI- 1673
Cdd:pfam01576  549 RLQRELEALTQQLEEKaaaydkLEKTKNRLQQelddllvDLDHQRQLVSNLEKKQKKFDQMLAEEKAISARYAEERDRAe 628

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1674 ----EELQKNLLNANLSEDEKEQLKKLMELKQSLECNLDQ------EMKKNV-ELEREITGFKNLLKMTRKKLNEYENgE 1742
Cdd:pfam01576  629 aearEKETRALSLARALEEALEAKEELERTNKQLRAEMEDlvsskdDVGKNVhELERSKRALEQQVEEMKTQLEELED-E 707

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1743 FSFHGDLKTsQFEMDIQINKLKHKiDDLTAELETAGSKCLHLDTKNQILQEELlsmKTVQKKCEKLQKNKKKLEQEVINL 1822
Cdd:pfam01576  708 LQATEDAKL-RLEVNMQALKAQFE-RDLQARDEQGEEKRRQLVKQVRELEAEL---EDERKQRAQAVAAKKKLELDLKEL 782

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1823 RSHIE----------RNMVEL-GQVKQYKQEIEE--RARQEIAEKLKEVNLFLQAQAAsqeNLEQFRENNFAS--MKSQM 1887
Cdd:pfam01576  783 EAQIDaankgreeavKQLKKLqAQMKDLQRELEEarASRDEILAQSKESEKKLKNLEA---ELLQLQEDLAASerARRQA 859

                          890       900       910       920       930       940       950
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2462517825 1888 ELRIKDLESEL---SKIKTSQEDfNKTELEKYKQLYLEELKVRKSLSSKLTKTNERLAEVNTKLLVEKQQSRSL 1958
Cdd:pfam01576  860 QQERDELADEIasgASGKSALQD-EKRRLEARIAQLEEELEEEQSNTELLNDRLRKSTLQVEQLTTELAAERST 932
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
1510-1948 1.68e-13

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 76.26  E-value: 1.68e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1510 QLDDAHNKADNKEKTVINIQDQFHAIVQKLQAESEKQSLL--LEERNKELISECNHL--KERQYQYENEKAEREV----- 1580
Cdd:PRK03918   156 GLDDYENAYKNLGEVIKEIKRRIERLEKFIKRTENIEELIkeKEKELEEVLREINEIssELPELREELEKLEKEVkelee 235

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1581 ---VVRQLQQELADTLKKQSMSEASLEVTSRYRINLEDETQDLKKKLGQIrNQLQEAQDRHTEAVRCAEKMQDHKQKLEK 1657
Cdd:PRK03918   236 lkeEIEELEKELESLEGSKRKLEEKIRELEERIEELKKEIEELEEKVKEL-KELKEKAEEYIKLSEFYEEYLDELREIEK 314

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1658 DNAKLKV---TVKKQMDKIEELQKNLlnANLSEDEKEQLKKLMELKQSLEcNLDQEMKKNVELEREITGFKNL-LKMTRK 1733
Cdd:PRK03918   315 RLSRLEEeinGIEERIKELEEKEERL--EELKKKLKELEKRLEELEERHE-LYEEAKAKKEELERLKKRLTGLtPEKLEK 391

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1734 KLNEYENGEFSFHGDLKtsqfEMDIQINKLKHKIDDLTA---ELETAGSKC------LHLDTKNQILQEELLSMKTVQKK 1804
Cdd:PRK03918   392 ELEELEKAKEEIEEEIS----KITARIGELKKEIKELKKaieELKKAKGKCpvcgreLTEEHRKELLEEYTAELKRIEKE 467

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1805 CEKLQKNKKKLEQEVINLRSHI--ERNMVELGQVKQYKQEIEER----------ARQEIAEKLKEVNLFLQAQAASQENl 1872
Cdd:PRK03918   468 LKEIEEKERKLRKELRELEKVLkkESELIKLKELAEQLKELEEKlkkynleeleKKAEEYEKLKEKLIKLKGEIKSLKK- 546

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1873 EQFRENNFASMKSQMELRIKDLESELSKIKT--------SQEDFNKT--ELEKYKQLYLE----------ELKVRKSLSS 1932
Cdd:PRK03918   547 ELEKLEELKKKLAELEKKLDELEEELAELLKeleelgfeSVEELEERlkELEPFYNEYLElkdaekelerEEKELKKLEE 626

                          490
                   ....*....|....*.
gi 2462517825 1933 KLTKTNERLAEVNTKL 1948
Cdd:PRK03918   627 ELDKAFEELAETEKRL 642
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 9-220 1.23e-12

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 72.33  E-value: 1.23e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825    9 GESPLgSFARRRRSSAGGGGEPGEGAYsqPGYHVRDRDlGKIHKAASAGNVAKVQQILLLRKNGLNDRDKMNRTALHLAC 88
Cdd:PHA02875    35 GISPI-KLAMKFRDSEAIKLLMKHGAI--PDVKYPDIE-SELHDAVEEGDVKAVEELLDLGKFADDVFYKDGMTPLHLAT 110

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825   89 ANGHPEVVTLLVDRKCQLNVCDNENRTALMKAVQCQEEKCATILLEHGADPNLADVHGNTALHYAVYNEDISVATKLLLY 168
Cdd:PHA02875   111 ILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKGIELLIDHKACLDIEDCCGCTPLIIAMAKGDIAICKMLLDS 190

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|...
gi 2462517825  169 DANIEAKNKD-DLTPLLLAVSGKKQQMVEFLIKKKANVNAVDKLESSHQLISE 220
Cdd:PHA02875   191 GANIDYFGKNgCVAALCYAIENNKIDIVRLFIKRGADCNIMFMIEGEECTILD 243
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 1086-1633 3.07e-12

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 72.28  E-value: 3.07e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1086 LLKIQDAALSCERL---LELKKNHCELLTVKIKKMEDKVNVLQRELSETKEIKSQLEHQKVEWERELCSLRFSLNQEEEK 1162
Cdd:COG1196    231 LLKLRELEAELEELeaeLEELEAELEELEAELAELEAELEELRLELEELELELEEAQAEEYELLAELARLEQDIARLEER 310

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1163 RRNADTLYEKIREQLRRKEEQYRKEVEVKQQLELSLQTLEMELRTVKSNLNQV-------VQERNDAQRQLSREQNARML 1235
Cdd:COG1196    311 RRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAeealleaEAELAEAEEELEELAEELLE 390

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1236 QDGILTNHLSKQKEIEMAQKKMNSENSHSHEEEKDLSHKNSMLQEEIAMLRLEIDTIKNQNQEKEkkcfEDLKIVKEKNE 1315
Cdd:COG1196    391 ALRAAAELAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELE----EEEEALLELLA 466

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1316 DLQKTIKQNEETLTQTISQYNGRLSVLTAENAMLNSKLENEKQSKERLEAEVESYHSRLAAAIHDRDQSETSKRELELAf 1395
Cdd:COG1196    467 ELLEEAALLEAALAELLEELAEAAARLLLLLEAEADYEGFLEGVKAALLLAGLRGLAGAVAVLIGVEAAYEAALEAALA- 545

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1396 qrardecSRLQDKMNFDVSNLKDNNEILSQQLFKTESKLNSLEIEfhhtRDALREKTLGLERVQKDLSQTQCQMKEMEQK 1475
Cdd:COG1196    546 -------AALQNIVVEDDEVAAAAIEYLKAAKAGRATFLPLDKIR----ARAALAAALARGAIGAAVDLVASDLREADAR 614

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1476 Y---QNEQVKVNKYIGKQESVEERLSQLQSENMLLRQQLDDAHNKADNKEKTVINIQDQFHAIVQKLQAESEKQS---LL 1549
Cdd:COG1196    615 YyvlGDTLLGRTLVAARLEAALRRAVTLAGRLREVTLEGEGGSAGGSLTGGSRRELLAALLEAEAELEELAERLAeeeLE 694

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1550 LEERNKELISECNHLKERQYQYENEKAEREVVVRQLQQELADTLKKQSMSEASLEVTSRYRINLEDETQDLKKKLGQIRN 1629
Cdd:COG1196    695 LEEALLAEEEEERELAEAEEERLEEELEEEALEEQLEAEREELLEELLEEEELLEEEALEELPEPPDLEELERELERLER 774


                   ....
gi 2462517825 1630 QLQE 1633
Cdd:COG1196    775 EIEA 778
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 1102-1538 1.94e-11

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 69.28  E-value: 1.94e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1102 LKKNHCELLTVKIKKMEDKVNVLQRELSETKEIKSQLEHQKVEWERELCSLRFSLNQEEEKRRNADTLYEKIREQLRRKE 1181
Cdd:TIGR04523  194 NKLLKLELLLSNLKKKIQKNKSLESQISELKKQNNQLKDNIEKKQQEINEKTTEISNTQTQLNQLKDEQNKIKKQLSEKQ 273

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1182 EQYRKEVEVKQQLELSLQTLEMEL------------RTVKSNLNQVVQERNDAQRQLSR-EQNARMLQDGIL-------- 1240
Cdd:TIGR04523  274 KELEQNNKKIKELEKQLNQLKSEIsdlnnqkeqdwnKELKSELKNQEKKLEEIQNQISQnNKIISQLNEQISqlkkeltn 353

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1241 --TNHLSKQKEIEMAQKKMNSENshshEEEKDLSHKNSMLQEEIAMLRLEIDTIKNQNQEKEKKcfedLKIVKEKNEDLQ 1318
Cdd:TIGR04523  354 seSENSEKQRELEEKQNEIEKLK----KENQSYKQEIKNLESQINDLESKIQNQEKLNQQKDEQ----IKKLQQEKELLE 425

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1319 KTIKQneetLTQTISQYNGRLSVLTAENAMLNSKLENEKQSKERLEAEVESYHSRLAAAIHDRDQSE---TSKRELELAF 1395
Cdd:TIGR04523  426 KEIER----LKETIIKNNSEIKDLTNQDSVKELIIKNLDNTRESLETQLKVLSRSINKIKQNLEQKQkelKSKEKELKKL 501

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1396 QRARDECSRLQDKMNFDVSNLKDNNEILSQQLFKTESKLNSLE-----IEFHHTRDALREKTLG-------LERVQKDLS 1463
Cdd:TIGR04523  502 NEEKKELEEKVKDLTKKISSLKEKIEKLESEKKEKESKISDLEdelnkDDFELKKENLEKEIDEknkeieeLKQTQKSLK 581

                          410       420       430       440       450       460       470
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2462517825 1464 QTQCQMKEMEQKYQNEQVKVNK----YIGKQESVEERLSQLQSENMLLRQQLDDAHNKADNKEKTVINIQDQFHAIVQK 1538
Cdd:TIGR04523  582 KKQEEKQELIDQKEKEKKDLIKeieeKEKKISSLEKELEKAKKENEKLSSIIKNIKSKKNKLKQEVKQIKETIKEIRNK 660
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 1160-1775 2.66e-11

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 69.20  E-value: 2.66e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1160 EEKRRNADTL---------YEKIREQLRRKEEQYRkeVEVKQQLELSLQTLEMELRTVKSNLNQVVQERNDAQRQLSREQ 1230
Cdd:COG1196    196 GELERQLEPLerqaekaerYRELKEELKELEAELL--LLKLRELEAELEELEAELEELEAELEELEAELAELEAELEELR 273

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1231 NArmlqdgiltnHLSKQKEIEMAQKKMNSENSHSHEEEKDLSHknsmLQEEIAMLRLEIDTIKNQNQEKEkkcfedlkiv 1310
Cdd:COG1196    274 LE----------LEELELELEEAQAEEYELLAELARLEQDIAR----LEERRRELEERLEELEEELAELE---------- 329

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1311 kEKNEDLQKTIKQNEETLTQtisqyngrlsvltaenamlnskLENEKQSKERLEAEVESYHSRLAAAIHDRDQSETSKRE 1390
Cdd:COG1196    330 -EELEELEEELEELEEELEE----------------------AEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAE 386

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1391 LELAFQRARDECSRLQDKMNFDVSNLKDNNEILSQQLFKTESKLNSLEIEFHHTRDALREKTLGLERVQKDLSQTQCQMK 1470
Cdd:COG1196    387 ELLEALRAAAELAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLA 466

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1471 EMEQKYQNEQVKVnkyigkQESVEERLSQLQSENMLLRQQLDDAHNKADNKEKTVINIQDQFHAIVQKLQAESEKQSLLL 1550
Cdd:COG1196    467 ELLEEAALLEAAL------AELLEELAEAAARLLLLLEAEADYEGFLEGVKAALLLAGLRGLAGAVAVLIGVEAAYEAAL 540

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1551 EERNKELIsecnhlkeRQYQYENEKAEREVVVRQLQQELA-------DTLKKQSMSEASLE--VTSRYRINLEDETQDLK 1621
Cdd:COG1196    541 EAALAAAL--------QNIVVEDDEVAAAAIEYLKAAKAGratflplDKIRARAALAAALArgAIGAAVDLVASDLREAD 612

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1622 KKLGQIRNQLQEAQDRHTEAVRCAEKMQDHKQKLE------------KDNAKLKVTVKKQMDKIEELQKNLLNANLSEDE 1689
Cdd:COG1196    613 ARYYVLGDTLLGRTLVAARLEAALRRAVTLAGRLRevtlegeggsagGSLTGGSRRELLAALLEAEAELEELAERLAEEE 692

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1690 KEQLKKLMELKQSLEcNLDQEMKKNVELEREITGFKNLLKMTRKKLNEYENGEFSFHGDLKTSQFEMDIQINKLKHKIDD 1769
Cdd:COG1196    693 LELEEALLAEEEEER-ELAEAEEERLEEELEEEALEEQLEAEREELLEELLEEEELLEEEALEELPEPPDLEELERELER 771


                   ....*.
gi 2462517825 1770 LTAELE 1775
Cdd:COG1196    772 LEREIE 777
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
1161-1729 1.49e-10

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 66.63  E-value: 1.49e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1161 EKRRNADTLYEKIREQLRRKEEQYRKEVEVKQQLELSLQTLEMELRTVKSNLNQVVQERNDAQRQLSR-EQNARMLQdgi 1239
Cdd:PRK03918   158 DDYENAYKNLGEVIKEIKRRIERLEKFIKRTENIEELIKEKEKELEEVLREINEISSELPELREELEKlEKEVKELE--- 234

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1240 ltnhlSKQKEIEMAQKKMNSENSHSHEEEKDLSHknsmLQEEIAMLRLEIDTIKNQNQE-----KEKKCFEDLKIVKEKN 1314
Cdd:PRK03918   235 -----ELKEEIEELEKELESLEGSKRKLEEKIRE----LEERIEELKKEIEELEEKVKElkelkEKAEEYIKLSEFYEEY 305

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1315 EDLQKTIKQNEETLTQTISQYNGRLSVLTAENAMLNSKLENEKQSKERLE----------------AEVESYHSRLAA-- 1376
Cdd:PRK03918   306 LDELREIEKRLSRLEEEINGIEERIKELEEKEERLEELKKKLKELEKRLEeleerhelyeeakakkEELERLKKRLTGlt 385

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1377 ---AIHDRDQSETSKRELELAFQRARDECSRLQDKmnfdVSNLKDNNEILSQQlfKTESKLNSLEIEFHHTRDALREKTL 1453
Cdd:PRK03918   386 pekLEKELEELEKAKEEIEEEISKITARIGELKKE----IKELKKAIEELKKA--KGKCPVCGRELTEEHRKELLEEYTA 459

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1454 GLERVQKDLSQTqcqmKEMEQKYQNEQVKVNKYIGKQ-------------ESVEERLSQLQSENM--------LLRQQLD 1512
Cdd:PRK03918   460 ELKRIEKELKEI----EEKERKLRKELRELEKVLKKEseliklkelaeqlKELEEKLKKYNLEELekkaeeyeKLKEKLI 535

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1513 DAHNKADNKEKTVINIQD---QFHAIVQKLQAESEKQSLLLEERNKELISECNHLKERQYQYEnEKAEREVVVRQLQQEL 1589
Cdd:PRK03918   536 KLKGEIKSLKKELEKLEElkkKLAELEKKLDELEEELAELLKELEELGFESVEELEERLKELE-PFYNEYLELKDAEKEL 614

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1590 ADTLKKQSMSEASLEVTsryrinlEDETQDLKKKLGQIRNQLQEAQDRHTEAVRcaEKMQDHKQKLEKDNAKLKVTVKKQ 1669
Cdd:PRK03918   615 EREEKELKKLEEELDKA-------FEELAETEKRLEELRKELEELEKKYSEEEY--EELREEYLELSRELAGLRAELEEL 685

                          570       580       590       600       610       620
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1670 MDKIEELQKNLlnanlsEDEKEQLKKLMELKQSLEcNLDQEMKKNVELEREITGFKNLLK 1729
Cdd:PRK03918   686 EKRREEIKKTL------EKLKEELEEREKAKKELE-KLEKALERVEELREKVKKYKALLK 738
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 1755-1928 6.50e-06

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 49.54  E-value: 6.50e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1755 EMDIQINKLKHKIDDLTAELEtagskclHLDTKNQILQEELlsmKTVQKKCEKLQKNKKKLEQEVINLRSHIERNMVELG 1834
Cdd:COG1579     14 ELDSELDRLEHRLKELPAELA-------ELEDELAALEARL---EAAKTELEDLEKEIKRLELEIEEVEARIKKYEEQLG 83

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1835 QVKQYKQ------EIE--ERARQEIAEKLKEVNLFLQAQAASQENLEQF---RENNFASMKSQMELRIKDLESELSKIKT 1903
Cdd:COG1579     84 NVRNNKEyealqkEIEslKRRISDLEDEILELMERIEELEEELAELEAElaeLEAELEEKKAELDEELAELEAELEELEA 163

                          170       180
                   ....*....|....*....|....*
gi 2462517825 1904 SQEDFNKTELEKYKQLYlEELKVRK 1928
Cdd:COG1579    164 EREELAAKIPPELLALY-ERIRKRK 187
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 82-202 8.01e-06

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 51.17  E-value: 8.01e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825   82 TALHLACANGHPEVVTLLVDRKCQLN------VCDNENRTALMK--------AVQCQEEKCATILLEHGADPNLADVHGN 147
Cdd:cd22192     91 TALHIAVVNQNLNLVRELIARGADVVspratgTFFRPGPKNLIYygehplsfAACVGNEEIVRLLIEHGADIRAQDSLGN 170

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2462517825  148 TALHYAVYNEDISVATK----LLLYDANIEA------KNKDDLTPLLLAVSGKKQQMVEFLIKKK 202
Cdd:cd22192    171 TVLHILVLQPNKTFACQmydlILSYDKEDDLqpldlvPNNQGLTPFKLAAKEGNIVMFQHLVQKR 235
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 1672-1956 8.09e-06

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 51.21  E-value: 8.09e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1672 KIEELQKNL--LNANLSEDEK---------EQLKKLMELKQSLEcnldqemkknvELEREITGfkNLLKMTRKKLNEyen 1740
Cdd:TIGR02168  180 KLERTRENLdrLEDILNELERqlkslerqaEKAERYKELKAELR-----------ELELALLV--LRLEELREELEE--- 243

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1741 gefsfhgdLKTSQFEMDIQINKLKHKIDDLTAELETAGSKCLHLDTKNQILQEELLSMKTVQKKCEK-----------LQ 1809
Cdd:TIGR02168  244 --------LQEELKEAEEELEELTAELQELEEKLEELRLEVSELEEEIEELQKELYALANEISRLEQqkqilrerlanLE 315

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1810 KNKKKLEQEVINLRSHIERNMVELGQVKQYKQEIE---ERARQEIAEKLKEVNLFLQAQAASQENLEQFReNNFASMKSQ 1886
Cdd:TIGR02168  316 RQLEELEAQLEELESKLDELAEELAELEEKLEELKeelESLEAELEELEAELEELESRLEELEEQLETLR-SKVAQLELQ 394

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2462517825 1887 MEL---RIKDLESELSKIKTSQEDFNKTELEKYKQLYLEELK-VRKSLSSK---LTKTNERLAEVNTKLLVEKQQSR 1956
Cdd:TIGR02168  395 IASlnnEIERLEARLERLEDRRERLQQEIEELLKKLEEAELKeLQAELEELeeeLEELQEELERLEEALEELREELE 471
trp TIGR00870
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ...
 82-202 1.23e-05

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273311 [Multi-domain]  Cd Length: 743  Bit Score: 50.46  E-value: 1.23e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825   82 TALHLACANGHPEVVTLLVDRKCQLNV---CD-------------NENRTALMKAVQcqEEKCATILLEHGADPNLADVH 145
Cdd:TIGR00870  130 TALHLAAHRQNYEIVKLLLERGASVPAracGDffvksqgvdsfyhGESPLNAAACLG--SPSIVALLSEDPADILTADSL 207

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462517825  146 GNTALHYAVYNEDISVATK---------LLLYDANI-------EAKNKDDLTPLLLAVSGKKQQMVEFLIKKK 202
Cdd:TIGR00870  208 GNTLLHLLVMENEFKAEYEelscqmynfALSLLDKLrdskeleVILNHQGLTPLKLAAKEGRIVLFRLKLAIK 280
PRK05771 PRK05771
V-type ATP synthase subunit I; Validated
 1664-1938 6.62e-05

V-type ATP synthase subunit I; Validated


Pssm-ID: 235600 [Multi-domain]  Cd Length: 646  Bit Score: 48.00  E-value: 6.62e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1664 VTVKKQMDK-IEELQKnlLNA----NLSEDEK-EQLKKLMELKQSLECNLDQeMKKNVELEReiTGFKNLLKMTRKKLNE 1737
Cdd:PRK05771    12 VTLKSYKDEvLEALHE--LGVvhieDLKEELSnERLRKLRSLLTKLSEALDK-LRSYLPKLN--PLREEKKKVSVKSLEE 86

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1738 YENGEFSFHGDLKTSQFEMDIQINKLKHKIDDLTAELETAgSKCLHLDtknqILQEELLSMKTVQKKCEKLQKNKKKLEQ 1817
Cdd:PRK05771    87 LIKDVEEELEKIEKEIKELEEEISELENEIKELEQEIERL-EPWGNFD----LDLSLLLGFKYVSVFVGTVPEDKLEELK 161

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1818 EVINLRSHIErnmvelgqVKQYKQE------IEERARQEIAEKLKEVNLflqaqaasqENLEQFRENNFASMKSQMELRI 1891
Cdd:PRK05771   162 LESDVENVEY--------ISTDKGYvyvvvvVLKELSDEVEEELKKLGF---------ERLELEEEGTPSELIREIKEEL 224

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1892 KDLESELSKIKTSQEDFNKtELEKYKQLYLEEL---KVRKSLSSKLTKTN 1938
Cdd:PRK05771   225 EEIEKERESLLEELKELAK-KYLEELLALYEYLeieLERAEALSKFLKTD 273
EzrA pfam06160
Septation ring formation regulator, EzrA; During the bacterial cell cycle, the tubulin-like ...
 1621-1953 1.10e-04

Septation ring formation regulator, EzrA; During the bacterial cell cycle, the tubulin-like cell-division protein FtsZ polymerizes into a ring structure that establishes the location of the nascent division site. EzrA modulates the frequency and position of FtsZ ring formation. The structure contains 5 spectrin like alpha helical repeats.


Pssm-ID: 428797 [Multi-domain]  Cd Length: 542  Bit Score: 47.16  E-value: 1.10e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1621 KKKLGQIRNQLQEAQDRhteavrcAEKMQDHKQKLEKDNAKLKVTVKKQMDKIEELQKNLLNANLS-------------- 1686
Cdd:pfam06160   85 KKALDEIEELLDDIEED-------IKQILEELDELLESEEKNREEVEELKDKYRELRKTLLANRFSygpaidelekqlae 157

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1687 -EDEKEQLKKLMELKQSLECN--LDQEMKKNVELEREITGFKNLLKMTRK----KLNEYENGefsfHGDLKTSQF----- 1754
Cdd:pfam06160  158 iEEEFSQFEELTESGDYLEARevLEKLEEETDALEELMEDIPPLYEELKTelpdQLEELKEG----YREMEEEGYalehl 233

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1755 EMDIQINKLKHKIDDLTAELETagskcLHLDT---KNQILQEELLSM-----------KTVQKKCEKLQKNKKKLEQEVI 1820
Cdd:pfam06160  234 NVDKEIQQLEEQLEENLALLEN-----LELDEaeeALEEIEERIDQLydllekevdakKYVEKNLPEIEDYLEHAEEQNK 308

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1821 NLRSHIER-------NMVELGQVKQYKQEIE--ERARQEIAEKLKEvnlflQAQAasqenleqfrennfasmKSQMELRI 1891
Cdd:pfam06160  309 ELKEELERvqqsytlNENELERVRGLEKQLEelEKRYDEIVERLEE-----KEVA-----------------YSELQEEL 366

                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462517825 1892 KDLESELSKIKTSQEDFNktelEKYKQLYLEELKVRKslssKLTKTNERLAEVntKLLVEKQ 1953
Cdd:pfam06160  367 EEILEQLEEIEEEQEEFK----ESLQSLRKDELEARE----KLDEFKLELREI--KRLVEKS 418
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 79-108 7.88e-04

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 38.72  E-value: 7.88e-04
                            10        20        30
                    ....*....|....*....|....*....|
gi 2462517825    79 MNRTALHLACANGHPEVVTLLVDRKCQLNV 108
Cdd:smart00248    1 DGRTPLHLAAENGNLEVVKLLLDKGADINA 30
SPEC cd00176
Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members ...
 1543-1740 1.40e-03

Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; the repeats are independent folding units; tandem repeats are found in differing numbers and arrange in an antiparallel manner to form dimers; the repeats are defined by a characteristic tryptophan (W) residue in helix A and a leucine (L) at the carboxyl end of helix C and separated by a linker of 5 residues; two copies of the repeat are present here


Pssm-ID: 238103 [Multi-domain]  Cd Length: 213  Bit Score: 42.43  E-value: 1.40e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1543 SEKQSLLLEERNKELISECNHLKERQYQYENEKAEREVVVRQLQQeLADTLkKQSMSEASLEVTSRYRiNLEDETQDLKK 1622
Cdd:cd00176     17 SEKEELLSSTDYGDDLESVEALLKKHEALEAELAAHEERVEALNE-LGEQL-IEEGHPDAEEIQERLE-ELNQRWEELRE 93

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1623 KLGQIRNQLQEAQDRHT---EAVRCAEKMQDHKQKLEK-DNAKLKVTVKKQMDKIEELQKNLlnanlsEDEKEQLKKLME 1698
Cdd:cd00176     94 LAEERRQRLEEALDLQQffrDADDLEQWLEEKEAALASeDLGKDLESVEELLKKHKELEEEL------EAHEPRLKSLNE 167

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....
gi 2462517825 1699 LKQSL--ECNLDQEMKKNVELEREITGFKNLLKMTRKKLNEYEN 1740
Cdd:cd00176    168 LAEELleEGHPDADEEIEEKLEELNERWEELLELAEERQKKLEE 211
 
Name Accession Description Interval E-value
CCDC144C pfam14915
CCDC144C protein coiled-coil region; This family includes the human protein CCDC144C and the ...
 1275-1578 8.22e-166

CCDC144C protein coiled-coil region; This family includes the human protein CCDC144C and the ankyrin repeat domain-containing protein 26-like 1 found in eukaryotes. Its function remains unknown, however, it is known to contain a coiled-coil domain which corresponds to this region. The ankyrin repeat which features in this protein is a common amino acid motif.


Pssm-ID: 464371 [Multi-domain]  Cd Length: 304  Bit Score: 509.91  E-value: 8.22e-166
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1275 NSMLQEEIAMLRLEIDTIKNQNQEKEKKCFEDLKIVKEKNEDLQKTIKQNEETLTQTISQYNGRLSVLTAENAMLNSKLE 1354
Cdd:pfam14915    1 NCMLQDEIAMLRLEIDTIKNQNQEKEKKYLEDIEILKEKNDDLQKTLKLNEETLTKTVFQYNGQLNVLKAENTMLNSKLE 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1355 NEKQSKERLEAEVESYHSRLAAAIHDRDQSETSKRELELAFQRARDECSRLQDKMNFDVSNLKDNNEILSQQLFKTESKL 1434
Cdd:pfam14915   81 NEKQNKERLETEVESYRSRLAAAIQDHEQSQTSKRDLELAFQRERDEWLRLQDKMNFDVSNLRDENEILSQQLSKAESKA 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1435 NSLEIEFHHTRDALREKTLGLERVQKDLSQTQCQMKEMEQKYQNEQVKVNKYIGKQESVEERLSQLQSENMLLRQQLDDA 1514
Cdd:pfam14915  161 NSLENELHRTRDALREKTLLLESVQRDLSQAQCQKKELEHMYQNEQDKVNKYIGKQESLEERLAQLQSENMLLRQQLEDA 240

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2462517825 1515 HNKADNKEKTVINIQDQFHAIVQKLQAESEKQSLLLEERNKELISECNHLKERQYQYENEKAER 1578
Cdd:pfam14915  241 QNKADAKEKTVIDIQDQFQDIVKKLQAESEKQVLLLEERNKELINECNHLKERLYQYEKEKAER 304
DUF3496 pfam12001
Domain of unknown function (DUF3496); This presumed domain is functionally uncharacterized. ...
 1884-1992 2.11e-57

Domain of unknown function (DUF3496); This presumed domain is functionally uncharacterized. This domain is found in eukaryotes. This domain is about 110 amino acids in length.


Pssm-ID: 463425 [Multi-domain]  Cd Length: 109  Bit Score: 193.73  E-value: 2.11e-57
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1884 KSQMELRIKDLESELSKIKTSQEDFNKTELEKYKQLYLEELKVRKSLSSKLTKTNERLAEVNTKLLVEKQQSRSLFTTLT 1963
Cdd:pfam12001    1 RSQMELRIKDLESELSKMKTSQEDSNKIELEKYKQLYLEELKVRKSLSNKLNKTNERLAEVSTKLLVEKQQNRSLLSTLT 80

                           90       100
                   ....*....|....*....|....*....
gi 2462517825 1964 TRPVMEPPCVGNLNNSLDLNRKLIPRENL 1992
Cdd:pfam12001   81 TRPVLESPCVGNLNNSLVLNRNFIPRENL 109
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
44-210 6.52e-39

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 147.79  E-value: 6.52e-39
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825   44 DRDLGKIHKAASAGNVAKVQQILLLRKNGLNDRDKMNRTALHLACANGHPEVVTLLVDRKCQLNVCDNENRTALMKAVQC 123
Cdd:COG0666     51 DALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYN 130

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825  124 QEEKCATILLEHGADPNLADVHGNTALHYAVYNEDISVATKLLLYDANIEAKNKDDLTPLLLAVSGKKQQMVEFLIKKKA 203
Cdd:COG0666    131 GNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGA 210


                   ....*..
gi 2462517825  204 NVNAVDK 210
Cdd:COG0666    211 DVNAKDN 217
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
50-218 5.35e-38

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 145.10  E-value: 5.35e-38
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825   50 IHKAASAGNVAKVQqiLLLRKNG-LNDRDKMNRTALHLACANGHPEVVTLLVDRKCQLNVCDNENRTALMKAVQCQEEKC 128
Cdd:COG0666     91 LHAAARNGDLEIVK--LLLEAGAdVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEI 168

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825  129 ATILLEHGADPNLADVHGNTALHYAVYNEDISVATKLLLYDANIEAKNKDDLTPLLLAVSGKKQQMVEFLIKKKANVNAV 208
Cdd:COG0666    169 VKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAK 248

                          170
                   ....*....|
gi 2462517825  209 DKLESSHQLI 218
Cdd:COG0666    249 DKDGLTALLL 258
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
50-210 1.48e-31

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 126.61  E-value: 1.48e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825   50 IHKAASAGNVAKVQqilLLRKNG--LNDRDKMNRTALHLACANGHPEVVTLLVDRKCQLNVCDNENRTALMKAVQCQEEK 127
Cdd:COG0666    124 LHLAAYNGNLEIVK---LLLEAGadVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLE 200

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825  128 CATILLEHGADPNLADVHGNTALHYAVYNEDISVATKLLLYDANIEAKNKDDLTPLLLAVSGKKQQMVEFLIKKKANVNA 207
Cdd:COG0666    201 IVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAA 280


                   ...
gi 2462517825  208 VDK 210
Cdd:COG0666    281 ALL 283
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
44-210 1.02e-28

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 118.13  E-value: 1.02e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825   44 DRDLGKIHKAASAGNVAKVQQILLLRKNGLNDRDKMNRTALHLACANGHPEVVTLLVDRKCQLNVCDNENRTALMKAVQC 123
Cdd:COG0666     18 LLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARN 97

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825  124 QEEKCATILLEHGADPNLADVHGNTALHYAVYNEDISVATKLLLYDANIEAKNKDDLTPLLLAVSGKKQQMVEFLIKKKA 203
Cdd:COG0666     98 GDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGA 177


                   ....*..
gi 2462517825  204 NVNAVDK 210
Cdd:COG0666    178 DVNARDN 184
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 1108-1775 7.52e-21

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 100.52  E-value: 7.52e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1108 ELLTVKIKKMEDKVNVLQRELSETKEIKSQLEHQKVEWERELCSLRFSL-----------NQEEEKRRNADTLYEKI--- 1173
Cdd:TIGR02168  270 EELRLEVSELEEEIEELQKELYALANEISRLEQQKQILRERLANLERQLeeleaqleeleSKLDELAEELAELEEKLeel 349

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1174 REQLRRKEEQYRKEVEVKQQLELSLQTLEMELRTVKSNLNQVVQERNDAQRQLSR-----EQNARMLQ--DGILTNHLSK 1246
Cdd:TIGR02168  350 KEELESLEAELEELEAELEELESRLEELEEQLETLRSKVAQLELQIASLNNEIERlearlERLEDRRErlQQEIEELLKK 429

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1247 QKEIEMAQKKMNSENSHSHEEEKDLSHKN-----SMLQEEIAMLRLEIDTIKNQNQEKEKKCfEDLKIVKEKNEDLQKTI 1321
Cdd:TIGR02168  430 LEEAELKELQAELEELEEELEELQEELERleealEELREELEEAEQALDAAERELAQLQARL-DSLERLQENLEGFSEGV 508

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1322 KQNEETLTQtISQYNGRLSVL--------TAENAMLNSKL-----ENEKQSKERLEAEVESYHSRLAAAIHDR------D 1382
Cdd:TIGR02168  509 KALLKNQSG-LSGILGVLSELisvdegyeAAIEAALGGRLqavvvENLNAAKKAIAFLKQNELGRVTFLPLDSikgteiQ 587

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1383 QSETSKRELELAFQRARDEC----SRLQDKMNF------DVSNLKDNNEILSQQLFktESKLNSLEIEFHHTRDAL---- 1448
Cdd:TIGR02168  588 GNDREILKNIEGFLGVAKDLvkfdPKLRKALSYllggvlVVDDLDNALELAKKLRP--GYRIVTLDGDLVRPGGVItggs 665

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1449 REKTLGLERVQKDLSQTQCQMKEMEQKYQNEQVKVNKYIGKQESVEERLSQLQSENMLLRQQLDDAHNKADNKEKTVINI 1528
Cdd:TIGR02168  666 AKTNSSILERRREIEELEEKIEELEEKIAELEKALAELRKELEELEEELEQLRKELEELSRQISALRKDLARLEAEVEQL 745

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1529 QDQfhaiVQKLQAESEKQSLLLEERNKELISECNHLKERqyqyENEKAEREVVVRQLQQELadtlkkQSMSEASLEVTSR 1608
Cdd:TIGR02168  746 EER----IAQLSKELTELEAEIEELEERLEEAEEELAEA----EAEIEELEAQIEQLKEEL------KALREALDELRAE 811

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1609 YRiNLEDETQDLKKKLGQIRNQLQEAQDRHTEAVRCAEKMQDHKQKLEKDNAKLKVTVKKQMDKIEELQK---------- 1678
Cdd:TIGR02168  812 LT-LLNEEAANLRERLESLERRIAATERRLEDLEEQIEELSEDIESLAAEIEELEELIEELESELEALLNerasleeala 890

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1679 --NLLNANLSEDEKEQLKKLMELKQslecNLDQEMKKNVELEREITGFKNLLKMTRKKLNEYENGEFsfhGDLKTSQFEM 1756
Cdd:TIGR02168  891 llRSELEELSEELRELESKRSELRR----ELEELREKLAQLELRLEGLEVRIDNLQERLSEEYSLTL---EEAEALENKI 963

                          730
                   ....*....|....*....
gi 2462517825 1757 DIQINKLKHKIDDLTAELE 1775
Cdd:TIGR02168  964 EDDEEEARRRLKRLENKIK 982
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 1101-1919 1.39e-20

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 99.75  E-value: 1.39e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1101 ELKKNHCELLTVKIKKMEDKVNVLQRELSETKEIKSQLEHQKVEWERELCSLRFSLNQEEEKRRNADTLYEKIREQLRRK 1180
Cdd:TIGR02168  221 ELRELELALLVLRLEELREELEELQEELKEAEEELEELTAELQELEEKLEELRLEVSELEEEIEELQKELYALANEISRL 300

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1181 EEQYRKEVEVKQQLELSLQTLEMELRTVKSNLNQVVQERNDAQRQLsreqnarmlqDGILTNHLSKQKEIEMAQKKMnsE 1260
Cdd:TIGR02168  301 EQQKQILRERLANLERQLEELEAQLEELESKLDELAEELAELEEKL----------EELKEELESLEAELEELEAEL--E 368

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1261 NSHSHEEEKDLSHKNsmLQEEIAMLRLEIDTIKNQNQEKEKKcfedLKIVKEKNEDLQKTIKQNEETLTqtisqyNGRLS 1340
Cdd:TIGR02168  369 ELESRLEELEEQLET--LRSKVAQLELQIASLNNEIERLEAR----LERLEDRRERLQQEIEELLKKLE------EAELK 436

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1341 VLTAENAMLNSKLENEKQSKERLEAEVESYHSRLAAAIHDRDQsetSKRELELAFQRARDECSRLQDKMNF--DVSNLKD 1418
Cdd:TIGR02168  437 ELQAELEELEEELEELQEELERLEEALEELREELEEAEQALDA---AERELAQLQARLDSLERLQENLEGFseGVKALLK 513

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1419 NNEILSQ------QLFKTESKLnsleiefhhtRDALrEKTLGlERVQKDLSQT-QCQMKEMEQKYQNEQVKVN----KYI 1487
Cdd:TIGR02168  514 NQSGLSGilgvlsELISVDEGY----------EAAI-EAALG-GRLQAVVVENlNAAKKAIAFLKQNELGRVTflplDSI 581

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1488 GKQESVEERLSQLQSENMLLRQQLDdaHNKADNK-EKTVINIQDQFHaIVQKLQAESEKQSLLLEERNkeLISECNHLKE 1566
Cdd:TIGR02168  582 KGTEIQGNDREILKNIEGFLGVAKD--LVKFDPKlRKALSYLLGGVL-VVDDLDNALELAKKLRPGYR--IVTLDGDLVR 656

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1567 RQYQYENEKAEREVVVRQLQQELADTLKKQSMSEASLEVTSRYRINLEDETQDLKKKLGQIRNQLQEAQDRHTEAVRCAE 1646
Cdd:TIGR02168  657 PGGVITGGSAKTNSSILERRREIEELEEKIEELEEKIAELEKALAELRKELEELEEELEQLRKELEELSRQISALRKDLA 736

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1647 KMQDHKQKLEKDNAKLKVTVKKQMDKIEELQKNLlnanlsEDEKEQLKKLMELKQSLECNLDQEMKKNVELEREITGFKN 1726
Cdd:TIGR02168  737 RLEAEVEQLEERIAQLSKELTELEAEIEELEERL------EEAEEELAEAEAEIEELEAQIEQLKEELKALREALDELRA 810

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1727 LLKMTRKKLNEYENGEFSF---HGDLKTSQFEMDIQINKLKHKIDDLTAELETAgskclhldtknQILQEELlsmktvQK 1803
Cdd:TIGR02168  811 ELTLLNEEAANLRERLESLerrIAATERRLEDLEEQIEELSEDIESLAAEIEEL-----------EELIEEL------ES 873

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1804 KCEKLQKNKKKLEQEVINLRSHIERNMVELGQVKQYKQEIeERARQEIAEKLKEVNLFLQ-AQAASQENLEQFREN---- 1878
Cdd:TIGR02168  874 ELEALLNERASLEEALALLRSELEELSEELRELESKRSEL-RRELEELREKLAQLELRLEgLEVRIDNLQERLSEEyslt 952

                          810       820       830       840
                   ....*....|....*....|....*....|....*....|....*.
gi 2462517825 1879 --NFASMKSQMELRIKDLESELSKIKTSQEDF---NKTELEKYKQL 1919
Cdd:TIGR02168  953 leEAEALENKIEDDEEEARRRLKRLENKIKELgpvNLAAIEEYEEL 998
Ank_2 pfam12796
Ankyrin repeats (3 copies);
84-176 1.58e-20

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 87.86  E-value: 1.58e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825   84 LHLACANGHPEVVTLLVDRKCQLNVCDNENRTALMKAVQCQEEKCATILLEHgADPNLADvHGNTALHYAVYNEDISVAT 163
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKD-NGRTALHYAARSGHLEIVK 78

                           90
                   ....*....|...
gi 2462517825  164 KLLLYDANIEAKN 176
Cdd:pfam12796   79 LLLEKGADINVKD 91
Ank_2 pfam12796
Ankyrin repeats (3 copies);
50-143 5.32e-20

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 86.32  E-value: 5.32e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825   50 IHKAASAGNVAKVQQiLLLRKNGLNDRDKMNRTALHLACANGHPEVVTLLVDrKCQLNVCDNeNRTALMKAVQCQEEKCA 129
Cdd:pfam12796    1 LHLAAKNGNLELVKL-LLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLE-HADVNLKDN-GRTALHYAARSGHLEIV 77

                           90
                   ....*....|....
gi 2462517825  130 TILLEHGADPNLAD 143
Cdd:pfam12796   78 KLLLEKGADINVKD 91
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
50-183 9.83e-20

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 91.94  E-value: 9.83e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825   50 IHKAASAGNVAKVQqiLLLrKNG--LNDRDKMNRTALHLACANGHPEVVTLLVDRKCQLNVCDNENRTALMKAVQCQEEK 127
Cdd:COG0666    157 LHLAAANGNLEIVK--LLL-EAGadVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLE 233

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 2462517825  128 CATILLEHGADPNLADVHGNTALHYAVYNEDISVATKLLLYDANIEAKNKDDLTPL 183
Cdd:COG0666    234 IVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLTLL 289
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 1114-1920 1.89e-19

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 95.89  E-value: 1.89e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1114 IKKMEDKVNVLQRELSET---KEIKSQLEhqkvEWERELCSLRFslNQEEEKRrnadtlyEKIREQLRRKEEQYRKEVEV 1190
Cdd:TIGR02168  195 LNELERQLKSLERQAEKAeryKELKAELR----ELELALLVLRL--EELREEL-------EELQEELKEAEEELEELTAE 261

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1191 KQQLELSLQTLEMELRTVKSNLNQVVQERNDAQRQLSR-EQNARMLQDGiLTNHLSKQKEIEMAQKKMNSENSHSHEEEK 1269
Cdd:TIGR02168  262 LQELEEKLEELRLEVSELEEEIEELQKELYALANEISRlEQQKQILRER-LANLERQLEELEAQLEELESKLDELAEELA 340

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1270 DLSHKNSMLQEEIAMLRLEIDTIKNQNQEKEKK---CFEDLKIVKEKNEDLQKTIKQNEETLTQ---TISQYNGRLSVLT 1343
Cdd:TIGR02168  341 ELEEKLEELKEELESLEAELEELEAELEELESRleeLEEQLETLRSKVAQLELQIASLNNEIERleaRLERLEDRRERLQ 420

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1344 AENAMLNSKLENEKQSK-----ERLEAEVESYHSRLAAAIHDRDQSETSKRELELAFQRARDECSRLQDKMNFdVSNLKD 1418
Cdd:TIGR02168  421 QEIEELLKKLEEAELKElqaelEELEEELEELQEELERLEEALEELREELEEAEQALDAAERELAQLQARLDS-LERLQE 499

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1419 NNEILSQ---QLFKTESKLNSLE------IEFHHTRDALREKTLGlERVQKDLSQT-QCQMKEMEQKYQNEQVKVN---- 1484
Cdd:TIGR02168  500 NLEGFSEgvkALLKNQSGLSGILgvlselISVDEGYEAAIEAALG-GRLQAVVVENlNAAKKAIAFLKQNELGRVTflpl 578

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1485 KYIGKQESVEERLSQLQSENMLLRQQLDdaHNKADNK-EKTVINIQDQFHaIVQKLQ----------------------- 1540
Cdd:TIGR02168  579 DSIKGTEIQGNDREILKNIEGFLGVAKD--LVKFDPKlRKALSYLLGGVL-VVDDLDnalelakklrpgyrivtldgdlv 655

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1541 ---------AESEKQSLL--------LEERNKELISECNHLKERQYQYENEKAEREVVVRQLQQELADTLKKQSMSEASL 1603
Cdd:TIGR02168  656 rpggvitggSAKTNSSILerrreieeLEEKIEELEEKIAELEKALAELRKELEELEEELEQLRKELEELSRQISALRKDL 735

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1604 EVTSRYRINLEDETQDLKKKLGQIRNQLQEAQDRHTEAVRCAEKMQDHKQKLEKDNAKLKVTVKKQMDKIEELQKNLlna 1683
Cdd:TIGR02168  736 ARLEAEVEQLEERIAQLSKELTELEAEIEELEERLEEAEEELAEAEAEIEELEAQIEQLKEELKALREALDELRAEL--- 812

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1684 nlsEDEKEQLKKLMELKQSLECNLDQEMKKNVELEREITGFKNLLKMTRKKLNEYENGEFSFHGDLKTSQFEMD---IQI 1760
Cdd:TIGR02168  813 ---TLLNEEAANLRERLESLERRIAATERRLEDLEEQIEELSEDIESLAAEIEELEELIEELESELEALLNERAsleEAL 889

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1761 NKLKHKIDDLTAELETAGSKCLHLDTKNQILQEELLSMKTVQKKCE-KLQKNKKKL-EQEVINLRSHIERNMVELGQVKQ 1838
Cdd:TIGR02168  890 ALLRSELEELSEELRELESKRSELRRELEELREKLAQLELRLEGLEvRIDNLQERLsEEYSLTLEEAEALENKIEDDEEE 969

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1839 YKQEIeERARQEIAEkLKEVNLflqaqaasqENLEQFRENN--FASMKSQMElrikDLESELSKIKTSQEDFNKTELEKY 1916
Cdd:TIGR02168  970 ARRRL-KRLENKIKE-LGPVNL---------AAIEEYEELKerYDFLTAQKE----DLTEAKETLEEAIEEIDREARERF 1034


                   ....
gi 2462517825 1917 KQLY 1920
Cdd:TIGR02168 1035 KDTF 1038
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
65-210 3.44e-18

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 87.32  E-value: 3.44e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825   65 ILLLRKNGLNDRDKMNRTALHLACANGHPEVVTLLVDRKCQLNVCDNENRTALMKAVQCQEEKCATILLEHGADPNLADV 144
Cdd:COG0666      6 LLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDD 85

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462517825  145 HGNTALHYAVYNEDISVATKLLLYDANIEAKNKDDLTPLLLAVSGKKQQMVEFLIKKKANVNAVDK 210
Cdd:COG0666     86 GGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDN 151
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 1097-1859 3.27e-16

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 85.50  E-value: 3.27e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1097 ERLLELKKNHCELLTVKIKKMEDKVNVLQRELSE-TKEIKSQLEHQKVEWERELCSLRFSLNQEEEKRRNADTLYEKIRE 1175
Cdd:TIGR02169  243 ERQLASLEEELEKLTEEISELEKRLEEIEQLLEElNKKIKDLGEEEQLRVKEKIGELEAEIASLERSIAEKERELEDAEE 322

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1176 QLRRKEEQYRKEVEVKQQLELSLQTLEMELRTVKSNLNQVVQERNDAQRQL-SREQNARMLQDgiltNHLSKQKEIEMAQ 1254
Cdd:TIGR02169  323 RLAKLEAEIDKLLAEIEELEREIEEERKRRDKLTEEYAELKEELEDLRAELeEVDKEFAETRD----ELKDYREKLEKLK 398

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1255 KKMNSenshsheeekdLSHKNSMLQEEIAMLRLEIDTIKNQNQEKEkkcfEDLKIVKEKNEDLQKTIKQNEETLTQTISQ 1334
Cdd:TIGR02169  399 REINE-----------LKRELDRLQEELQRLSEELADLNAAIAGIE----AKINELEEEKEDKALEIKKQEWKLEQLAAD 463

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1335 yngrlsvltaenamlnskLENEKQSKERLEAEVESYHSRLaaaihdrdqsetSKRELELAFQRARDECSRLQDKMNFDVS 1414
Cdd:TIGR02169  464 ------------------LSKYEQELYDLKEEYDRVEKEL------------SKLQRELAEAEAQARASEERVRGGRAVE 513

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1415 NLKDNNeilSQQLFKTESKLNSLE-----------------------------IEFHHTRDALREKTLGLERVQKDLSQT 1465
Cdd:TIGR02169  514 EVLKAS---IQGVHGTVAQLGSVGeryataievaagnrlnnvvveddavakeaIELLKRRKAGRATFLPLNKMRDERRDL 590

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1466 QCQMK-----------EMEQKYQNEQVKVNKYIGKQESVEERLSQLQSENML-LRQQLDD---AHNKADNKEKTVINIQD 1530
Cdd:TIGR02169  591 SILSEdgvigfavdlvEFDPKYEPAFKYVFGDTLVVEDIEAARRLMGKYRMVtLEGELFEksgAMTGGSRAPRGGILFSR 670

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1531 QFHAIVQKLQAESEKqsllLEERNKELISECNHLKER--QYQYENEKAEREVVVRQ-----LQQELADTLKKQSMSEASL 1603
Cdd:TIGR02169  671 SEPAELQRLRERLEG----LKRELSSLQSELRRIENRldELSQELSDASRKIGEIEkeieqLEQEEEKLKERLEELEEDL 746

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1604 EVTSRYRINLEDETQDLKKKLGQIRNQLQEAQdrhtEAVRCAEKMQDHK--QKLEKDNAKLKVTVKKQMDKIEELQKNLl 1681
Cdd:TIGR02169  747 SSLEQEIENVKSELKELEARIEELEEDLHKLE----EALNDLEARLSHSriPEIQAELSKLEEEVSRIEARLREIEQKL- 821

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1682 naNLSEDEKEQLKKLMELKQS----LECNLDQEMKKNVELEREITGFKNLLKMTRKKLNEYEngefSFHGDLKTSQFEMD 1757
Cdd:TIGR02169  822 --NRLTLEKEYLEKEIQELQEqridLKEQIKSIEKEIENLNGKKEELEEELEELEAALRDLE----SRLGDLKKERDELE 895

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1758 IQINKLKHKIDDLTAELETAGSKCLHLDTKNQILQEEL-----------------LSMKTVQKKCEKLQKNKKKLEQevI 1820
Cdd:TIGR02169  896 AQLRELERKIEELEAQIEKKRKRLSELKAKLEALEEELseiedpkgedeeipeeeLSLEDVQAELQRVEEEIRALEP--V 973

                          810       820       830       840
                   ....*....|....*....|....*....|....*....|
gi 2462517825 1821 NLRSHIERNMVELGQVK-QYKQEIEERARQEIAEKLKEVN 1859
Cdd:TIGR02169  974 NMLAIQEYEEVLKRLDElKEKRAKLEEERKAILERIEEYE 1013
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
 1086-1958 3.55e-15

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 82.15  E-value: 3.55e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1086 LLKIQDAALSCERLL-ELKKNHCELLTVKiKKMEDKVNVLQRELSETKEIKSQLEHQKVEWERELCSLRFSLNQEEEKRR 1164
Cdd:pfam01576   14 LQKVKERQQKAESELkELEKKHQQLCEEK-NALQEQLQAETELCAEAEEMRARLAARKQELEEILHELESRLEEEEERSQ 92

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1165 NADTLYEKIREQLRRKEEQYRKEVEVKQQLELSLQTLEMELRTVKSNLNQVvqerNDAQRQLSREQNARMLQDGILTNHL 1244
Cdd:pfam01576   93 QLQNEKKKMQQHIQDLEEQLDEEEAARQKLQLEKVTTEAKIKKLEEDILLL----EDQNSKLSKERKLLEERISEFTSNL 168

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1245 SKQKE---------------IEMAQKKMNSENSHSHEEEK---DLSHKNSMLQEEIAMLRLEIDTIKNQNQEKEkkcfed 1306
Cdd:pfam01576  169 AEEEEkakslsklknkheamISDLEERLKKEEKGRQELEKakrKLEGESTDLQEQIAELQAQIAELRAQLAKKE------ 242

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1307 lkivkeknEDLQKTIKQNEETLTQTiSQYNGRLSVLTAENAMLNSKLENEKQSKER-------LEAEVESYHSRLAAAIH 1379
Cdd:pfam01576  243 --------EELQAALARLEEETAQK-NNALKKIRELEAQISELQEDLESERAARNKaekqrrdLGEELEALKTELEDTLD 313

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1380 DR--DQSETSKRELELA-FQRARDECSRLQDKMNFDVSNLKDNN-EILSQQLFKTESKLNSLEiefhHTRDALREKTLGL 1455
Cdd:pfam01576  314 TTaaQQELRSKREQEVTeLKKALEEETRSHEAQLQEMRQKHTQAlEELTEQLEQAKRNKANLE----KAKQALESENAEL 389

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1456 ERVQKDLSQ----TQCQMKEMEQKYQNEQVKVNKYIGKQESVEERLSQLQSENMLLRQQLDDAHNKADNKEKTVINIQDQ 1531
Cdd:pfam01576  390 QAELRTLQQakqdSEHKRKKLEGQLQELQARLSESERQRAELAEKLSKLQSELESVSSLLNEAEGKNIKLSKDVSSLESQ 469

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1532 FHAiVQKLQAESEKQSLLLEERNKELISECNHLKERQYQYENEKAEREVVVRQLQQELADTLKKQ----SMSEASLEVTS 1607
Cdd:pfam01576  470 LQD-TQELLQEETRQKLNLSTRLRQLEDERNSLQEQLEEEEEAKRNVERQLSTLQAQLSDMKKKLeedaGTLEALEEGKK 548

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1608 RYRINLEDETQDLKKK------LGQIRNQLQE-------AQDRHTEAVRCAEKMQDHKQKLEKDNAKLKVTVKKQMDKI- 1673
Cdd:pfam01576  549 RLQRELEALTQQLEEKaaaydkLEKTKNRLQQelddllvDLDHQRQLVSNLEKKQKKFDQMLAEEKAISARYAEERDRAe 628

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1674 ----EELQKNLLNANLSEDEKEQLKKLMELKQSLECNLDQ------EMKKNV-ELEREITGFKNLLKMTRKKLNEYENgE 1742
Cdd:pfam01576  629 aearEKETRALSLARALEEALEAKEELERTNKQLRAEMEDlvsskdDVGKNVhELERSKRALEQQVEEMKTQLEELED-E 707

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1743 FSFHGDLKTsQFEMDIQINKLKHKiDDLTAELETAGSKCLHLDTKNQILQEELlsmKTVQKKCEKLQKNKKKLEQEVINL 1822
Cdd:pfam01576  708 LQATEDAKL-RLEVNMQALKAQFE-RDLQARDEQGEEKRRQLVKQVRELEAEL---EDERKQRAQAVAAKKKLELDLKEL 782

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1823 RSHIE----------RNMVEL-GQVKQYKQEIEE--RARQEIAEKLKEVNLFLQAQAAsqeNLEQFRENNFAS--MKSQM 1887
Cdd:pfam01576  783 EAQIDaankgreeavKQLKKLqAQMKDLQRELEEarASRDEILAQSKESEKKLKNLEA---ELLQLQEDLAASerARRQA 859

                          890       900       910       920       930       940       950
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2462517825 1888 ELRIKDLESEL---SKIKTSQEDfNKTELEKYKQLYLEELKVRKSLSSKLTKTNERLAEVNTKLLVEKQQSRSL 1958
Cdd:pfam01576  860 QQERDELADEIasgASGKSALQD-EKRRLEARIAQLEEELEEEQSNTELLNDRLRKSTLQVEQLTTELAAERST 932
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
 1114-1895 1.09e-14

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 80.55  E-value: 1.09e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1114 IKKMEDKVNVLQRELSETKEIKsqlEHQKVEWERELCSLRFSLnQEEEKRRNAdtlyekiREQLRRKEEQYRKEVevKQQ 1193
Cdd:pfam15921   80 LEEYSHQVKDLQRRLNESNELH---EKQKFYLRQSVIDLQTKL-QEMQMERDA-------MADIRRRESQSQEDL--RNQ 146

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1194 LELSLQTLEMElRTVKSNLnqvvqeRNDAQRQLSREQNARMLQDGILTNHLSKQKEIEMAQ-KKMNSENSHSHEEEKDL- 1271
Cdd:pfam15921  147 LQNTVHELEAA-KCLKEDM------LEDSNTQIEQLRKMMLSHEGVLQEIRSILVDFEEASgKKIYEHDSMSTMHFRSLg 219

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1272 SHKNSMLQE---EIAMLRLEIDTIKNQNQEKEKKCFEDLKIVKEKNED-LQKTIKQNE---ETLTQTISQYNGRLSVLTA 1344
Cdd:pfam15921  220 SAISKILREldtEISYLKGRIFPVEDQLEALKSESQNKIELLLQQHQDrIEQLISEHEveiTGLTEKASSARSQANSIQS 299

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1345 ENAMLNSKLENEKQSKERLEAEVESYHSRLAAAIHD-----RDQSETSKRELELA---FQRARDEcsrlQDKMNFDVSNL 1416
Cdd:pfam15921  300 QLEIIQEQARNQNSMYMRQLSDLESTVSQLRSELREakrmyEDKIEELEKQLVLAnseLTEARTE----RDQFSQESGNL 375

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1417 KDNNEILSQQLFKTESKLnSLE---------------IEFHHTRDALREKTLGLERVQKDLS--QTQCQmKEMEQKYQNE 1479
Cdd:pfam15921  376 DDQLQKLLADLHKREKEL-SLEkeqnkrlwdrdtgnsITIDHLRRELDDRNMEVQRLEALLKamKSECQ-GQMERQMAAI 453

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1480 QvkvnkyiGKQESVEERLS---QLQSENMLLRQQLDDAHNKA---DNKEKTVINIQDQFHAIVQKLQAESEKQSLLLEER 1553
Cdd:pfam15921  454 Q-------GKNESLEKVSSltaQLESTKEMLRKVVEELTAKKmtlESSERTVSDLTASLQEKERAIEATNAEITKLRSRV 526

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1554 NKELiSECNHLKERQYQYENEKAErevvvrqlqqelADTLKKQsMSEASlEVTSRYRINLEDETQdLKKKLGQIRNQLQe 1633
Cdd:pfam15921  527 DLKL-QELQHLKNEGDHLRNVQTE------------CEALKLQ-MAEKD-KVIEILRQQIENMTQ-LVGQHGRTAGAMQ- 589

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1634 aqdrhTEAVRCAEKMQDHKQKLEKdnakLKVTVKKQMDKIEELQknllnANLSEDEKEQLKKLMELKQSLECnldqemKK 1713
Cdd:pfam15921  590 -----VEKAQLEKEINDRRLELQE----FKILKDKKDAKIRELE-----ARVSDLELEKVKLVNAGSERLRA------VK 649

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1714 NVELEREitGFKNLLKMTRKKLNEYENGEFSFHGDLKTSQFEMDIQINKLKHKIDDLTAELETAGS--KCLH-------- 1783
Cdd:pfam15921  650 DIKQERD--QLLNEVKTSRNELNSLSEDYEVLKRNFRNKSEEMETTTNKLKMQLKSAQSELEQTRNtlKSMEgsdghamk 727

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1784 ------------------LDTKNQILQEellSMKTVQKKCEKLQKNKKKLEQEVINLRSHIERNMVELGQVKQYKQEIEE 1845
Cdd:pfam15921  728 vamgmqkqitakrgqidaLQSKIQFLEE---AMTNANKEKHFLKEEKNKLSQELSTVATEKNKMAGELEVLRSQERRLKE 804

                          810       820       830       840       850
                   ....*....|....*....|....*....|....*....|....*....|.
gi 2462517825 1846 R-ARQEIAekLKEVNLflqaQAASQENLEQFRENNFASMKSQMELRIKDLE 1895
Cdd:pfam15921  805 KvANMEVA--LDKASL----QFAECQDIIQRQEQESVRLKLQHTLDVKELQ 849
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 1288-1948 8.22e-14

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 76.98  E-value: 8.22e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1288 EIDTIKNQ--NQEKEKKCFEDLKIVKEKN----EDLQKTIKQNEETLTQTISQYNGRLSVLTAENAMLNSKLENEKQSKE 1361
Cdd:TIGR04523   41 KLKTIKNElkNKEKELKNLDKNLNKDEEKinnsNNKIKILEQQIKDLNDKLKKNKDKINKLNSDLSKINSEIKNDKEQKN 120

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1362 RLEAEVESyhsrlaaaihdrdqsetSKRELElafqrardECSRLQDKMNFDVSNLKDNNEILSQQLFKTESKLNSLEIEF 1441
Cdd:TIGR04523  121 KLEVELNK-----------------LEKQKK--------ENKKNIDKFLTEIKKKEKELEKLNNKYNDLKKQKEELENEL 175

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1442 HHTRDALREKtlglervQKDLSQTQCQMKEMEQKYQNEQvkvnKYIGKQESVEERLSQLQSENMLLRQQLDDAHNKADNK 1521
Cdd:TIGR04523  176 NLLEKEKLNI-------QKNIDKIKNKLLKLELLLSNLK----KKIQKNKSLESQISELKKQNNQLKDNIEKKQQEINEK 244

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1522 EKTVINIQDQFHAIVQKLQAESEKqsllLEERNKELISECNHLKERQYQYENEKAEREVVVRQLQQELADTLKkqsmsea 1601
Cdd:TIGR04523  245 TTEISNTQTQLNQLKDEQNKIKKQ----LSEKQKELEQNNKKIKELEKQLNQLKSEISDLNNQKEQDWNKELK------- 313

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1602 slevtsryrinleDETQDLKKKLGQIRNQLQEAQDRHTEAVRCAEKMQDHKQKLEKDNAKLKVTVKKQMDKIEELQKNll 1681
Cdd:TIGR04523  314 -------------SELKNQEKKLEEIQNQISQNNKIISQLNEQISQLKKELTNSESENSEKQRELEEKQNEIEKLKKE-- 378

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1682 nanlSEDEKEQLKKLMELKQSLECNLDQEMKKNVELEREITGF---KNLLKMTRKKLNEYENGEFSFHGDLKTSQFEMDI 1758
Cdd:TIGR04523  379 ----NQSYKQEIKNLESQINDLESKIQNQEKLNQQKDEQIKKLqqeKELLEKEIERLKETIIKNNSEIKDLTNQDSVKEL 454

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1759 QINKLKHKIDDLTAELETAGSKCLHLDTKNQILQEELlsmKTVQKKCEKLQKNKKKLEQEVINLRSHIERNMVELGQVKQ 1838
Cdd:TIGR04523  455 IIKNLDNTRESLETQLKVLSRSINKIKQNLEQKQKEL---KSKEKELKKLNEEKKELEEKVKDLTKKISSLKEKIEKLES 531

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1839 YKQEIEERARQ------EIAEKLKEVNLFLQAQaASQENLEQFRENNFASMKSQMEL--RIKDLESELSKIKTSQEDFNK 1910
Cdd:TIGR04523  532 EKKEKESKISDledelnKDDFELKKENLEKEID-EKNKEIEELKQTQKSLKKKQEEKqeLIDQKEKEKKDLIKEIEEKEK 610

                          650       660       670
                   ....*....|....*....|....*....|....*...
gi 2462517825 1911 TELEKYKQLYLEELKVRKsLSSKLTKTNERLAEVNTKL 1948
Cdd:TIGR04523  611 KISSLEKELEKAKKENEK-LSSIIKNIKSKKNKLKQEV 647
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 1175-1936 1.06e-13

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 77.03  E-value: 1.06e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1175 EQLRRKEEQYRKEVEvkqQLELSLQTLEMELRTVKSNLNQVVQERNDAQR--QLSREqnarmLQDGILTNHLsKQKEIEM 1252
Cdd:TIGR02169  166 AEFDRKKEKALEELE---EVEENIERLDLIIDEKRQQLERLRREREKAERyqALLKE-----KREYEGYELL-KEKEALE 236

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1253 AQKKmnsenshshEEEKDLSHknsmLQEEIAMLRLEIDTIKNQNQEKEKKCFEDLKIVKEKNEDLQKTIKQNEETLTQTI 1332
Cdd:TIGR02169  237 RQKE---------AIERQLAS----LEEELEKLTEEISELEKRLEEIEQLLEELNKKIKDLGEEEQLRVKEKIGELEAEI 303

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1333 SQ-------YNGRLSVLTAENAMLNSKLENEKQSKERLEAEVESYHSRLAAAI----HDRDQSETSKRELE---LAFQRA 1398
Cdd:TIGR02169  304 ASlersiaeKERELEDAEERLAKLEAEIDKLLAEIEELEREIEEERKRRDKLTeeyaELKEELEDLRAELEevdKEFAET 383

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1399 RDECSRLQDKM----------NFDVSNLKDNNEILSQQLFKTESKLNSLEIEFHHTRDALREKTLGLERVQKDLSQTQCQ 1468
Cdd:TIGR02169  384 RDELKDYREKLeklkreinelKRELDRLQEELQRLSEELADLNAAIAGIEAKINELEEEKEDKALEIKKQEWKLEQLAAD 463

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1469 MKEMEQKYQNEQVKVNKYIGKQESVEERLSQLQSENMLLRQQLDDAHN-----KADN-------------KEKTVINIQ- 1529
Cdd:TIGR02169  464 LSKYEQELYDLKEEYDRVEKELSKLQRELAEAEAQARASEERVRGGRAveevlKASIqgvhgtvaqlgsvGERYATAIEv 543

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1530 ---DQFHAIVQKLQAESEKQSLLLEERN------------------KELISECNHLK--------ERQYQ---------- 1570
Cdd:TIGR02169  544 aagNRLNNVVVEDDAVAKEAIELLKRRKagratflplnkmrderrdLSILSEDGVIGfavdlvefDPKYEpafkyvfgdt 623

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1571 --YENEKAEREVVVR----QLQQELADtlKKQSMS----------------EASLEVTSRYRINLEDETQDLKKKLGQIR 1628
Cdd:TIGR02169  624 lvVEDIEAARRLMGKyrmvTLEGELFE--KSGAMTggsraprggilfsrsePAELQRLRERLEGLKRELSSLQSELRRIE 701

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1629 NQLQEAQDRHTEAVRCAEKMQDHKQKLEKDNAKLKVTVKKQMDKIEELQKNLlnanlsEDEKEQLKKLMELKQSLECNLD 1708
Cdd:TIGR02169  702 NRLDELSQELSDASRKIGEIEKEIEQLEQEEEKLKERLEELEEDLSSLEQEI------ENVKSELKELEARIEELEEDLH 775

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1709 QEMKKNVELEREITGFKnllkmTRKKLNEYEngefsfhgDLKTSQFEMDIQINKLKHKIDDLTAELETAGSKCLHL---- 1784
Cdd:TIGR02169  776 KLEEALNDLEARLSHSR-----IPEIQAELS--------KLEEEVSRIEARLREIEQKLNRLTLEKEYLEKEIQELqeqr 842

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1785 -DTKNQI--LQEELLSMKT----VQKKCEKLQKNKKKLEQEVINLRSHIERNMVELGQVKQYKQEIEERarqeiAEKLKE 1857
Cdd:TIGR02169  843 iDLKEQIksIEKEIENLNGkkeeLEEELEELEAALRDLESRLGDLKKERDELEAQLRELERKIEELEAQ-----IEKKRK 917

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1858 VNLFLQAQAASQENLEQFRENNFASMKS---------QMELRIKDLESELSKIktsqEDFNKTELEKYKqlylEELKVRK 1928
Cdd:TIGR02169  918 RLSELKAKLEALEEELSEIEDPKGEDEEipeeelsleDVQAELQRVEEEIRAL----EPVNMLAIQEYE----EVLKRLD 989


                   ....*...
gi 2462517825 1929 SLSSKLTK 1936
Cdd:TIGR02169  990 ELKEKRAK 997
sbcc TIGR00618
exonuclease SbcC; All proteins in this family for which functions are known are part of an ...
 1124-1818 1.09e-13

exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129705 [Multi-domain]  Cd Length: 1042  Bit Score: 76.93  E-value: 1.09e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1124 LQRELSETKEIKSQLEhqKVEWERELCSLRFSLNQEEEKRRNADTLYEKIREQLrrKEEQYRKEVEVKQQLELSLQTLEM 1203
Cdd:TIGR00618  158 LKAKSKEKKELLMNLF--PLDQYTQLALMEFAKKKSLHGKAELLTLRSQLLTLC--TPCMPDTYHERKQVLEKELKHLRE 233

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1204 ELRTVKSNLNQVVQERNDAQRQLSREQNARMLQDGI------LTNHLSKQKEIEMA------------------------ 1253
Cdd:TIGR00618  234 ALQQTQQSHAYLTQKREAQEEQLKKQQLLKQLRARIeelraqEAVLEETQERINRArkaaplaahikavtqieqqaqrih 313

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1254 ---QKKMNSENSHSHEEEKDLSHKNSMLQEEIAMLRLEIDTIKNQNQEKEKKCFEDLKIVKEKNEDLQKTIKQNEETLTQ 1330
Cdd:TIGR00618  314 telQSKMRSRAKLLMKRAAHVKQQSSIEEQRRLLQTLHSQEIHIRDAHEVATSIREISCQQHTLTQHIHTLQQQKTTLTQ 393

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1331 TISQYNGRLSVLTAENAM---LNSKLENEKQSKERLEAEVE---SYHSRLAAAIHDRDQSET-SKRELELAFQRARDECS 1403
Cdd:TIGR00618  394 KLQSLCKELDILQREQATidtRTSAFRDLQGQLAHAKKQQElqqRYAELCAAAITCTAQCEKlEKIHLQESAQSLKEREQ 473

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1404 RLQDKMNF--DVSNLKDNNEILSQQLFKTESKLNSLEIEFHHTRDALREktlglervqkdLSQTQCQMKEMEQKYQNEQV 1481
Cdd:TIGR00618  474 QLQTKEQIhlQETRKKAVVLARLLELQEEPCPLCGSCIHPNPARQDIDN-----------PGPLTRRMQRGEQTYAQLET 542

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1482 KVNKYIGKQESVEERLSQLQSENMLLRQQLdDAHNKADNKEKTVINIQDQfhaIVQKLQAESEKQSllleeRNKELISEC 1561
Cdd:TIGR00618  543 SEEDVYHQLTSERKQRASLKEQMQEIQQSF-SILTQCDNRSKEDIPNLQN---ITVRLQDLTEKLS-----EAEDMLACE 613

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1562 NHLKERQYQYENEKAEREVVVRQLQQELAdtLKKQSMSEASLEVT-SRYRINLEDETQDLKKKLGQIRNQLQEAQDRHTE 1640
Cdd:TIGR00618  614 QHALLRKLQPEQDLQDVRLHLQQCSQELA--LKLTALHALQLTLTqERVREHALSIRVLPKELLASRQLALQKMQSEKEQ 691

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1641 AV-------RCAEKMQDHKQKLEKDNAKLKVTVKKQMDKIEELQKNLLNANlsedekEQLKKLMELKQSLECNLDQE-MK 1712
Cdd:TIGR00618  692 LTywkemlaQCQTLLRELETHIEEYDREFNEIENASSSLGSDLAAREDALN------QSLKELMHQARTVLKARTEAhFN 765

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1713 KNVELEREITGFKNLLKMTRKKLNEYENGEFSFHgdlKTSQFEMDIQiNKLKHKIDDLTAELETAGSKCLHLDTKNQILQ 1792
Cdd:TIGR00618  766 NNEEVTAALQTGAELSHLAAEIQFFNRLREEDTH---LLKTLEAEIG-QEIPSDEDILNLQCETLVQEEEQFLSRLEEKS 841

                          730       740
                   ....*....|....*....|....*.
gi 2462517825 1793 EELLSMKTVQKKCEKLQKNKKKLEQE 1818
Cdd:TIGR00618  842 ATLGEITHQLLKYEECSKQLAQLTQE 867
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
1510-1948 1.68e-13

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 76.26  E-value: 1.68e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1510 QLDDAHNKADNKEKTVINIQDQFHAIVQKLQAESEKQSLL--LEERNKELISECNHL--KERQYQYENEKAEREV----- 1580
Cdd:PRK03918   156 GLDDYENAYKNLGEVIKEIKRRIERLEKFIKRTENIEELIkeKEKELEEVLREINEIssELPELREELEKLEKEVkelee 235

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1581 ---VVRQLQQELADTLKKQSMSEASLEVTSRYRINLEDETQDLKKKLGQIrNQLQEAQDRHTEAVRCAEKMQDHKQKLEK 1657
Cdd:PRK03918   236 lkeEIEELEKELESLEGSKRKLEEKIRELEERIEELKKEIEELEEKVKEL-KELKEKAEEYIKLSEFYEEYLDELREIEK 314

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1658 DNAKLKV---TVKKQMDKIEELQKNLlnANLSEDEKEQLKKLMELKQSLEcNLDQEMKKNVELEREITGFKNL-LKMTRK 1733
Cdd:PRK03918   315 RLSRLEEeinGIEERIKELEEKEERL--EELKKKLKELEKRLEELEERHE-LYEEAKAKKEELERLKKRLTGLtPEKLEK 391

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1734 KLNEYENGEFSFHGDLKtsqfEMDIQINKLKHKIDDLTA---ELETAGSKC------LHLDTKNQILQEELLSMKTVQKK 1804
Cdd:PRK03918   392 ELEELEKAKEEIEEEIS----KITARIGELKKEIKELKKaieELKKAKGKCpvcgreLTEEHRKELLEEYTAELKRIEKE 467

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1805 CEKLQKNKKKLEQEVINLRSHI--ERNMVELGQVKQYKQEIEER----------ARQEIAEKLKEVNLFLQAQAASQENl 1872
Cdd:PRK03918   468 LKEIEEKERKLRKELRELEKVLkkESELIKLKELAEQLKELEEKlkkynleeleKKAEEYEKLKEKLIKLKGEIKSLKK- 546

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1873 EQFRENNFASMKSQMELRIKDLESELSKIKT--------SQEDFNKT--ELEKYKQLYLE----------ELKVRKSLSS 1932
Cdd:PRK03918   547 ELEKLEELKKKLAELEKKLDELEEELAELLKeleelgfeSVEELEERlkELEPFYNEYLElkdaekelerEEKELKKLEE 626

                          490
                   ....*....|....*.
gi 2462517825 1933 KLTKTNERLAEVNTKL 1948
Cdd:PRK03918   627 ELDKAFEELAETEKRL 642
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 1298-1958 7.06e-13

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 74.32  E-value: 7.06e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1298 EKEKKCFEDLKIVKEKNEDLQKTI--------KQNEETLTQTISQYNGRLSVLTAENAMLNSKLENEKQSKERLEAEVES 1369
Cdd:TIGR02168  206 ERQAEKAERYKELKAELRELELALlvlrleelREELEELQEELKEAEEELEELTAELQELEEKLEELRLEVSELEEEIEE 285

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1370 YHSRLAAAihdrdQSETSKRELELAFQRARDEcsrlqdkmnfdvsNLKDNNEILSQQLFKTESKLNSLEIEFHHTRDALR 1449
Cdd:TIGR02168  286 LQKELYAL-----ANEISRLEQQKQILRERLA-------------NLERQLEELEAQLEELESKLDELAEELAELEEKLE 347

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1450 EKTLGLERVQKDLSQTQCQMKEMEQKYQNEQVKVNKYIGKQESVEERLSQLQSENMLLRQQLDDAhnkADNKEKTVINIQ 1529
Cdd:TIGR02168  348 ELKEELESLEAELEELEAELEELESRLEELEEQLETLRSKVAQLELQIASLNNEIERLEARLERL---EDRRERLQQEIE 424

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1530 DQfhaivqkLQAESEKQSLLLEERNKELISECNHLKERQYQYENEKAEREVVVRQLQQELADTLKKQSMSEASLEVTSRY 1609
Cdd:TIGR02168  425 EL-------LKKLEEAELKELQAELEELEEELEELQEELERLEEALEELREELEEAEQALDAAERELAQLQARLDSLERL 497

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1610 RINLEDETQDLKKKLgQIRNQLQEAQDRHTEAVRCAEK--------MQDHKQKLE--------------KDNAKLKVTV- 1666
Cdd:TIGR02168  498 QENLEGFSEGVKALL-KNQSGLSGILGVLSELISVDEGyeaaieaaLGGRLQAVVvenlnaakkaiaflKQNELGRVTFl 576

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1667 -----------KKQMDKIEELQKNLLNANLSEDEKEQLKKLME-----------LKQSLEC------------------- 1705
Cdd:TIGR02168  577 pldsikgteiqGNDREILKNIEGFLGVAKDLVKFDPKLRKALSyllggvlvvddLDNALELakklrpgyrivtldgdlvr 656

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1706 -----------------NLDQEMKKNV----ELEREITGFKNLLKMTRKKLNEYENGEfsfhGDLKTSQFEMDIQINKLK 1764
Cdd:TIGR02168  657 pggvitggsaktnssilERRREIEELEekieELEEKIAELEKALAELRKELEELEEEL----EQLRKELEELSRQISALR 732

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1765 HKIDDLTAELETAGSKCLHLDTKNQILQEEllsMKTVQKKCEKLQKNKKKLEQEVINLRSHIERNMVELGQVKQYKQEIE 1844
Cdd:TIGR02168  733 KDLARLEAEVEQLEERIAQLSKELTELEAE---IEELEERLEEAEEELAEAEAEIEELEAQIEQLKEELKALREALDELR 809

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1845 ERARQEIAE--KLKEVNLFLQAQAASQENLEQFRENNFAsmksQMELRIKDLESELSKIKTSQEDFNKtELEKYKQLYLE 1922
Cdd:TIGR02168  810 AELTLLNEEaaNLRERLESLERRIAATERRLEDLEEQIE----ELSEDIESLAAEIEELEELIEELES-ELEALLNERAS 884

                          730       740       750
                   ....*....|....*....|....*....|....*.
gi 2462517825 1923 ELKVRKSLSSKLTKTNERLAEVNTKLLVEKQQSRSL 1958
Cdd:TIGR02168  885 LEEALALLRSELEELSEELRELESKRSELRRELEEL 920
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 9-220 1.23e-12

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 72.33  E-value: 1.23e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825    9 GESPLgSFARRRRSSAGGGGEPGEGAYsqPGYHVRDRDlGKIHKAASAGNVAKVQQILLLRKNGLNDRDKMNRTALHLAC 88
Cdd:PHA02875    35 GISPI-KLAMKFRDSEAIKLLMKHGAI--PDVKYPDIE-SELHDAVEEGDVKAVEELLDLGKFADDVFYKDGMTPLHLAT 110

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825   89 ANGHPEVVTLLVDRKCQLNVCDNENRTALMKAVQCQEEKCATILLEHGADPNLADVHGNTALHYAVYNEDISVATKLLLY 168
Cdd:PHA02875   111 ILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKGIELLIDHKACLDIEDCCGCTPLIIAMAKGDIAICKMLLDS 190

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|...
gi 2462517825  169 DANIEAKNKD-DLTPLLLAVSGKKQQMVEFLIKKKANVNAVDKLESSHQLISE 220
Cdd:PHA02875   191 GANIDYFGKNgCVAALCYAIENNKIDIVRLFIKRGADCNIMFMIEGEECTILD 243
DUF3584 pfam12128
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ...
 1202-1948 1.24e-12

Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.


Pssm-ID: 432349 [Multi-domain]  Cd Length: 1191  Bit Score: 73.72  E-value: 1.24e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1202 EMELRTVKSNLNQVVQER--NDAQRQLSREQNARMLQDgiltnhlskqkeIEMAQKKMNsenshsheeekdLSHKNSMLQ 1279
Cdd:pfam12128  192 EGKFRDVKSMIVAILEDDgvVPPKSRLNRQQVEHWIRD------------IQAIAGIMK------------IRPEFTKLQ 247

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1280 EEIAMLR---LEIDTIKNQNQEKEKKCFEDLKIVKEKNEDLQKTIKQNEETLTQTISQYNGRLSVLTAENAMLNSKLEN- 1355
Cdd:pfam12128  248 QEFNTLEsaeLRLSHLHFGYKSDETLIASRQEERQETSAELNQLLRTLDDQWKEKRDELNGELSAADAAVAKDRSELEAl 327

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1356 EKQSKERLEAEVESYHSRLAAAIHDRDQSETSKRELELAFQRARD---ECSRLQDKM----NFDVSNLKDN----NEILS 1424
Cdd:pfam12128  328 EDQHGAFLDADIETAAADQEQLPSWQSELENLEERLKALTGKHQDvtaKYNRRRSKIkeqnNRDIAGIKDKlakiREARD 407

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1425 QQLFKTESKLNSLEIEFHHTRDA----LREKTLG----LERVQKDLSQTQCQMKEMEQKYQNeQVKVNKYIGKQESVEER 1496
Cdd:pfam12128  408 RQLAVAEDDLQALESELREQLEAgkleFNEEEYRlksrLGELKLRLNQATATPELLLQLENF-DERIERAREEQEAANAE 486

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1497 LSQLQSEnmllRQQLDDAHNKADNKEKtviniqdQFHAIVQKLQAESEKQSLLLEERNKELISECNHLKERQYQYENEKA 1576
Cdd:pfam12128  487 VERLQSE----LRQARKRRDQASEALR-------QASRRLEERQSALDELELQLFPQAGTLLHFLRKEAPDWEQSIGKVI 555

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1577 EREVVVR-QLQQELADTLKKQSMSEASLEVTSRyRINLED---ETQDLKKKLGQIRNQLQEAQDRHTEAvrcAEKMQDHK 1652
Cdd:pfam12128  556 SPELLHRtDLDPEVWDGSVGGELNLYGVKLDLK-RIDVPEwaaSEEELRERLDKAEEALQSAREKQAAA---EEQLVQAN 631

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1653 QKLekDNAKLKVTVKKQMDKIEELQKNLLNanlseDEKEQLKklMELKQSLECNLDQEMKKNVELEREitgfknllkmtr 1732
Cdd:pfam12128  632 GEL--EKASREETFARTALKNARLDLRRLF-----DEKQSEK--DKKNKALAERKDSANERLNSLEAQ------------ 690

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1733 KKLNeyengefsfhgDLKTSQFEMDIQINKLKHKIDDLTAELETAGSKCLHLDTKNQILQEELLSMKTVQKKCEKLQKNK 1812
Cdd:pfam12128  691 LKQL-----------DKKHQAWLEEQKEQKREARTEKQAYWQVVEGALDAQLALLKAAIAARRSGAKAELKALETWYKRD 759

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1813 -----------KKLEQEVINLRSHIERNMVELGQVKQYKQEIEER---ARQEIAEKLKEVN---LFLQAQAASQE----- 1870
Cdd:pfam12128  760 laslgvdpdviAKLKREIRTLERKIERIAVRRQEVLRYFDWYQETwlqRRPRLATQLSNIEraiSELQQQLARLIadtkl 839

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1871 NLEQFRENNFASMKSQMEL--RIKDLESELSKIKTSQEDFNKTELE---KYKQLYLEELK-VRKSLSSKLTKTNERLAEV 1944
Cdd:pfam12128  840 RRAKLEMERKASEKQQVRLseNLRGLRCEMSKLATLKEDANSEQAQgsiGERLAQLEDLKlKRDYLSESVKKYVEHFKNV 919


                   ....
gi 2462517825 1945 NTKL 1948
Cdd:pfam12128  920 IADH 923
SMC_N pfam02463
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
 1160-1955 2.46e-12

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


Pssm-ID: 426784 [Multi-domain]  Cd Length: 1161  Bit Score: 72.70  E-value: 2.46e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1160 EEKRRNADTLYEKIREQLRRKEEQYRKEVEVKQQL-------------ELSLQTLEMELRTVKSNLNQVVQERNDaqrQL 1226
Cdd:pfam02463  166 RLKRKKKEALKKLIEETENLAELIIDLEELKLQELklkeqakkaleyyQLKEKLELEEEYLLYLDYLKLNEERID---LL 242

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1227 SREQNARMLQDGILTNHLSKQKEIEMAQKKMNSENShshEEEKDLSHKNSMLQEEIAMLRLEIDTIKNQNQEKEKKCFED 1306
Cdd:pfam02463  243 QELLRDEQEEIESSKQEIEKEEEKLAQVLKENKEEE---KEKKLQEEELKLLAKEEEELKSELLKLERRKVDDEEKLKES 319

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1307 LKIVKEKNEDLQKTIKQNEETLTQTISQYNGRLSVLTAENAMLNSKLENEKQSKERLEAEVESYHSRLAAAIhdRDQSET 1386
Cdd:pfam02463  320 EKEKKKAEKELKKEKEEIEELEKELKELEIKREAEEEEEEELEKLQEKLEQLEEELLAKKKLESERLSSAAK--LKEEEL 397

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1387 SKRELELAFQRARDECSRLQDKMNFDVSNLKDNNEILSQQLFKTESKLNSLEIEFHHTRDALR-EKTLGLERVQKDLSQT 1465
Cdd:pfam02463  398 ELKSEEEKEAQLLLELARQLEDLLKEEKKEELEILEEEEESIELKQGKLTEEKEELEKQELKLlKDELELKKSEDLLKET 477

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1466 QCQMKEMEQKYQNEQVKVNKYIGKQESVEERLSQLQSENMLLRQ-QLDDAHNKADNKEKTVINIQdqfHAIVQKLQAESE 1544
Cdd:pfam02463  478 QLVKLQEQLELLLSRQKLEERSQKESKARSGLKVLLALIKDGVGgRIISAHGRLGDLGVAVENYK---VAISTAVIVEVS 554

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1545 KQSLLLEERNKELISECNHLKERQYQYENEKAEREVVVRQLQQELADTLKKQSMSEASLEVTSRYRINLEDET--QDLKK 1622
Cdd:pfam02463  555 ATADEVEERQKLVRALTELPLGARKLRLLIPKLKLPLKSIAVLEIDPILNLAQLDKATLEADEDDKRAKVVEGilKDTEL 634

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1623 KLGQIRNQLQEAQDRHTEAVRCAEKM-QDHKQKLEKDNAKLKVTVKKQMDKIEELQKNLLNANLSEDEKEQLKKLMELKQ 1701
Cdd:pfam02463  635 TKLKESAKAKESGLRKGVSLEEGLAEkSEVKASLSELTKELLEIQELQEKAESELAKEEILRRQLEIKKKEQREKEELKK 714

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1702 SLECNLDQEMKKNVELEREITGFKNLLKMTRKKLNEYENGEFSFHGDLKTSQFEMDIQINKLKHKIDDLTAELETAGSKc 1781
Cdd:pfam02463  715 LKLEAEELLADRVQEAQDKINEELKLLKQKIDEEEEEEEKSRLKKEEKEEEKSELSLKEKELAEEREKTEKLKVEEEKE- 793

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1782 lhldtKNQILQEELLSMKTVQKKCEKLQKNKKKLEQEVINLRSHIERNMVELGQVKQYKQEIEERARQEIAEKLKEVNLF 1861
Cdd:pfam02463  794 -----EKLKAQEEELRALEEELKEEAELLEEEQLLIEQEEKIKEEELEELALELKEEQKLEKLAEEELERLEEEITKEEL 868

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1862 LQAQAASQENLEQFRENNFASMKSQMELRIKDLESELSKIKTSQEDFNKTELEKYKQLYLEELKVRKSL--SSKLTKTNE 1939
Cdd:pfam02463  869 LQELLLKEEELEEQKLKDELESKEEKEKEEKKELEEESQKLNLLEEKENEIEERIKEEAEILLKYEEEPeeLLLEEADEK 948

                          810
                   ....*....|....*.
gi 2462517825 1940 RLAEVNTKLLVEKQQS 1955
Cdd:pfam02463  949 EKEENNKEEEEERNKR 964
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 1086-1633 3.07e-12

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 72.28  E-value: 3.07e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1086 LLKIQDAALSCERL---LELKKNHCELLTVKIKKMEDKVNVLQRELSETKEIKSQLEHQKVEWERELCSLRFSLNQEEEK 1162
Cdd:COG1196    231 LLKLRELEAELEELeaeLEELEAELEELEAELAELEAELEELRLELEELELELEEAQAEEYELLAELARLEQDIARLEER 310

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1163 RRNADTLYEKIREQLRRKEEQYRKEVEVKQQLELSLQTLEMELRTVKSNLNQV-------VQERNDAQRQLSREQNARML 1235
Cdd:COG1196    311 RRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAeealleaEAELAEAEEELEELAEELLE 390

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1236 QDGILTNHLSKQKEIEMAQKKMNSENSHSHEEEKDLSHKNSMLQEEIAMLRLEIDTIKNQNQEKEkkcfEDLKIVKEKNE 1315
Cdd:COG1196    391 ALRAAAELAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELE----EEEEALLELLA 466

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1316 DLQKTIKQNEETLTQTISQYNGRLSVLTAENAMLNSKLENEKQSKERLEAEVESYHSRLAAAIHDRDQSETSKRELELAf 1395
Cdd:COG1196    467 ELLEEAALLEAALAELLEELAEAAARLLLLLEAEADYEGFLEGVKAALLLAGLRGLAGAVAVLIGVEAAYEAALEAALA- 545

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1396 qrardecSRLQDKMNFDVSNLKDNNEILSQQLFKTESKLNSLEIEfhhtRDALREKTLGLERVQKDLSQTQCQMKEMEQK 1475
Cdd:COG1196    546 -------AALQNIVVEDDEVAAAAIEYLKAAKAGRATFLPLDKIR----ARAALAAALARGAIGAAVDLVASDLREADAR 614

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1476 Y---QNEQVKVNKYIGKQESVEERLSQLQSENMLLRQQLDDAHNKADNKEKTVINIQDQFHAIVQKLQAESEKQS---LL 1549
Cdd:COG1196    615 YyvlGDTLLGRTLVAARLEAALRRAVTLAGRLREVTLEGEGGSAGGSLTGGSRRELLAALLEAEAELEELAERLAeeeLE 694

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1550 LEERNKELISECNHLKERQYQYENEKAEREVVVRQLQQELADTLKKQSMSEASLEVTSRYRINLEDETQDLKKKLGQIRN 1629
Cdd:COG1196    695 LEEALLAEEEEERELAEAEEERLEEELEEEALEEQLEAEREELLEELLEEEELLEEEALEELPEPPDLEELERELERLER 774


                   ....
gi 2462517825 1630 QLQE 1633
Cdd:COG1196    775 EIEA 778
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 843-1633 3.66e-12

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 72.01  E-value: 3.66e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825  843 SANNYKSMEPELENVRSSpprgdRTSKVSLKEELQQDMQRFKNEIGMLKVEFQALEKEKVQLQKEVEeerkkhrnnemEV 922
Cdd:TIGR02168  230 LVLRLEELREELEELQEE-----LKEAEEELEELTAELQELEEKLEELRLEVSELEEEIEELQKELY-----------AL 293

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825  923 SANIHDGATDDAEDDDDDDGLIQKRKSGETDHQQFPRKENKEYASgpaLQMKEVKSTE-KEKRTSKESVNSPVFGKASLL 1001
Cdd:TIGR02168  294 ANEISRLEQQKQILRERLANLERQLEELEAQLEELESKLDELAEE---LAELEEKLEElKEELESLEAELEELEAELEEL 370

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1002 TGGLLQVDDDSslseidEDEGRPTKKTSNEKNKVKNQIQSMDD-VDDLTQSSETASEDcelphssyknfmllIEQLGMEc 1080
Cdd:TIGR02168  371 ESRLEELEEQL------ETLRSKVAQLELQIASLNNEIERLEArLERLEDRRERLQQE--------------IEELLKK- 429

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1081 kdsvslLKIQDAALSCERLLELKKnhcelltvKIKKMEDKVNVLQRELSETKEIKSQLEHQKVEWERELCSLRFSLNQEE 1160
Cdd:TIGR02168  430 ------LEEAELKELQAELEELEE--------ELEELQEELERLEEALEELREELEEAEQALDAAERELAQLQARLDSLE 495

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1161 EKRRNADTLYEKIREQLRRK----------------EEQYRKEVEVkqQLELSLQTLEMElrtvksNLNQVVQ-----ER 1219
Cdd:TIGR02168  496 RLQENLEGFSEGVKALLKNQsglsgilgvlselisvDEGYEAAIEA--ALGGRLQAVVVE------NLNAAKKaiaflKQ 567

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1220 NDAQRQL-------------SREQNARMLQDGILTNHLSKQKEIEMAQKKMNSENSHSHEEEkDLSHKNSMLQEEIAMLR 1286
Cdd:TIGR02168  568 NELGRVTflpldsikgteiqGNDREILKNIEGFLGVAKDLVKFDPKLRKALSYLLGGVLVVD-DLDNALELAKKLRPGYR 646

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1287 ---LEIDTIKN---------------QNQEKE-KKCFEDLKIVKEKNEDLQKTIKQNEETLtqtiSQYNGRLSVLTAENA 1347
Cdd:TIGR02168  647 ivtLDGDLVRPggvitggsaktnssiLERRREiEELEEKIEELEEKIAELEKALAELRKEL----EELEEELEQLRKELE 722

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1348 MLNSKLENEKQSKERLEAEVESYHSRLAAAIHDRDQSETSKRELELAFQRARDECSRLQDKMNfdvsNLKDNNEILSQQL 1427
Cdd:TIGR02168  723 ELSRQISALRKDLARLEAEVEQLEERIAQLSKELTELEAEIEELEERLEEAEEELAEAEAEIE----ELEAQIEQLKEEL 798

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1428 FKTESKLNSLEIEFHHTRDALREKTLGLERVQKDLSQTQCQMKEMEQKYQNEQVKVNKYIGKQESVEERLSQLQSEnmll 1507
Cdd:TIGR02168  799 KALREALDELRAELTLLNEEAANLRERLESLERRIAATERRLEDLEEQIEELSEDIESLAAEIEELEELIEELESE---- 874

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1508 rqqLDDAHNKADNKEKTVINIQDQFHAIVQKLQAesekqsllLEERNKELISECNHLKERQYQYENEKAEREVVVRQLQQ 1587
Cdd:TIGR02168  875 ---LEALLNERASLEEALALLRSELEELSEELRE--------LESKRSELRRELEELREKLAQLELRLEGLEVRIDNLQE 943

                          810       820       830       840
                   ....*....|....*....|....*....|....*....|....*.
gi 2462517825 1588 ELADTLkkqsmsEASLEVTSRYRINLEDETQDLKKKLGQIRNQLQE 1633
Cdd:TIGR02168  944 RLSEEY------SLTLEEAEALENKIEDDEEEARRRLKRLENKIKE 983
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 54-210 7.98e-12

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 69.69  E-value: 7.98e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825   54 ASAGNVAKVQQILLLRKNGLNDRDKMNRTALHLACAN--GHPEVVTLLVDRKCQLNVCDNENRTALMKAVQCQEEKCATI 131
Cdd:PHA03100    80 YNLTDVKEIVKLLLEYGANVNAPDNNGITPLLYAISKksNSYSIVEYLLDNGANVNIKNSDGENLLHLYLESNKIDLKIL 159

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825  132 ------------------LLEHGADPNLADVHGNTALHYAVYNEDISVATKLLLYDANIEAKNKDDLTPLLLAVSGKKQQ 193
Cdd:PHA03100   160 kllidkgvdinaknrvnyLLSYGVPINIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKE 239

                          170
                   ....*....|....*..
gi 2462517825  194 MVEFLIKKKANVNAVDK 210
Cdd:PHA03100   240 IFKLLLNNGPSIKTIIE 256
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 1102-1538 1.94e-11

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 69.28  E-value: 1.94e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1102 LKKNHCELLTVKIKKMEDKVNVLQRELSETKEIKSQLEHQKVEWERELCSLRFSLNQEEEKRRNADTLYEKIREQLRRKE 1181
Cdd:TIGR04523  194 NKLLKLELLLSNLKKKIQKNKSLESQISELKKQNNQLKDNIEKKQQEINEKTTEISNTQTQLNQLKDEQNKIKKQLSEKQ 273

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1182 EQYRKEVEVKQQLELSLQTLEMEL------------RTVKSNLNQVVQERNDAQRQLSR-EQNARMLQDGIL-------- 1240
Cdd:TIGR04523  274 KELEQNNKKIKELEKQLNQLKSEIsdlnnqkeqdwnKELKSELKNQEKKLEEIQNQISQnNKIISQLNEQISqlkkeltn 353

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1241 --TNHLSKQKEIEMAQKKMNSENshshEEEKDLSHKNSMLQEEIAMLRLEIDTIKNQNQEKEKKcfedLKIVKEKNEDLQ 1318
Cdd:TIGR04523  354 seSENSEKQRELEEKQNEIEKLK----KENQSYKQEIKNLESQINDLESKIQNQEKLNQQKDEQ----IKKLQQEKELLE 425

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1319 KTIKQneetLTQTISQYNGRLSVLTAENAMLNSKLENEKQSKERLEAEVESYHSRLAAAIHDRDQSE---TSKRELELAF 1395
Cdd:TIGR04523  426 KEIER----LKETIIKNNSEIKDLTNQDSVKELIIKNLDNTRESLETQLKVLSRSINKIKQNLEQKQkelKSKEKELKKL 501

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1396 QRARDECSRLQDKMNFDVSNLKDNNEILSQQLFKTESKLNSLE-----IEFHHTRDALREKTLG-------LERVQKDLS 1463
Cdd:TIGR04523  502 NEEKKELEEKVKDLTKKISSLKEKIEKLESEKKEKESKISDLEdelnkDDFELKKENLEKEIDEknkeieeLKQTQKSLK 581

                          410       420       430       440       450       460       470
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2462517825 1464 QTQCQMKEMEQKYQNEQVKVNK----YIGKQESVEERLSQLQSENMLLRQQLDDAHNKADNKEKTVINIQDQFHAIVQK 1538
Cdd:TIGR04523  582 KKQEEKQELIDQKEKEKKDLIKeieeKEKKISSLEKELEKAKKENEKLSSIIKNIKSKKNKLKQEVKQIKETIKEIRNK 660
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 1160-1775 2.66e-11

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 69.20  E-value: 2.66e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1160 EEKRRNADTL---------YEKIREQLRRKEEQYRkeVEVKQQLELSLQTLEMELRTVKSNLNQVVQERNDAQRQLSREQ 1230
Cdd:COG1196    196 GELERQLEPLerqaekaerYRELKEELKELEAELL--LLKLRELEAELEELEAELEELEAELEELEAELAELEAELEELR 273

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1231 NArmlqdgiltnHLSKQKEIEMAQKKMNSENSHSHEEEKDLSHknsmLQEEIAMLRLEIDTIKNQNQEKEkkcfedlkiv 1310
Cdd:COG1196    274 LE----------LEELELELEEAQAEEYELLAELARLEQDIAR----LEERRRELEERLEELEEELAELE---------- 329

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1311 kEKNEDLQKTIKQNEETLTQtisqyngrlsvltaenamlnskLENEKQSKERLEAEVESYHSRLAAAIHDRDQSETSKRE 1390
Cdd:COG1196    330 -EELEELEEELEELEEELEE----------------------AEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAE 386

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1391 LELAFQRARDECSRLQDKMNFDVSNLKDNNEILSQQLFKTESKLNSLEIEFHHTRDALREKTLGLERVQKDLSQTQCQMK 1470
Cdd:COG1196    387 ELLEALRAAAELAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLA 466

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1471 EMEQKYQNEQVKVnkyigkQESVEERLSQLQSENMLLRQQLDDAHNKADNKEKTVINIQDQFHAIVQKLQAESEKQSLLL 1550
Cdd:COG1196    467 ELLEEAALLEAAL------AELLEELAEAAARLLLLLEAEADYEGFLEGVKAALLLAGLRGLAGAVAVLIGVEAAYEAAL 540

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1551 EERNKELIsecnhlkeRQYQYENEKAEREVVVRQLQQELA-------DTLKKQSMSEASLE--VTSRYRINLEDETQDLK 1621
Cdd:COG1196    541 EAALAAAL--------QNIVVEDDEVAAAAIEYLKAAKAGratflplDKIRARAALAAALArgAIGAAVDLVASDLREAD 612

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1622 KKLGQIRNQLQEAQDRHTEAVRCAEKMQDHKQKLE------------KDNAKLKVTVKKQMDKIEELQKNLLNANLSEDE 1689
Cdd:COG1196    613 ARYYVLGDTLLGRTLVAARLEAALRRAVTLAGRLRevtlegeggsagGSLTGGSRRELLAALLEAEAELEELAERLAEEE 692

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1690 KEQLKKLMELKQSLEcNLDQEMKKNVELEREITGFKNLLKMTRKKLNEYENGEFSFHGDLKTSQFEMDIQINKLKHKIDD 1769
Cdd:COG1196    693 LELEEALLAEEEEER-ELAEAEEERLEEELEEEALEEQLEAEREELLEELLEEEELLEEEALEELPEPPDLEELERELER 771


                   ....*.
gi 2462517825 1770 LTAELE 1775
Cdd:COG1196    772 LEREIE 777
PHA03095 PHA03095
ankyrin-like protein; Provisional
 94-212 2.68e-11

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 68.51  E-value: 2.68e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825   94 EVVTLLVDRKCQLNVCDNENRTALMKAVQCQEEKCATI---LLEHGADPNLADVHGNTALHYAVYNED-ISVATKLLLYD 169
Cdd:PHA03095    28 EEVRRLLAAGADVNFRGEYGKTPLHLYLHYSSEKVKDIvrlLLEAGADVNAPERCGFTPLHLYLYNATtLDVIKLLIKAG 107

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*
gi 2462517825  170 ANIEAKNKDDLTPLLLAVSGK--KQQMVEFLIKKKANVNAVDKLE 212
Cdd:PHA03095   108 ADVNAKDKVGRTPLHVYLSGFniNPKVIRLLLRKGADVNALDLYG 152
rad50 TIGR00606
rad50; All proteins in this family for which functions are known are involvedin recombination, ...
 1021-1936 2.92e-11

rad50; All proteins in this family for which functions are known are involvedin recombination, recombinational repair, and/or non-homologous end joining.They are components of an exonuclease complex with MRE11 homologs. This family is distantly related to the SbcC family of bacterial proteins.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).


Pssm-ID: 129694 [Multi-domain]  Cd Length: 1311  Bit Score: 69.31  E-value: 2.92e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1021 EGRPTKKTSNEKNKVKNQIQSMDDVDDLTQSSETASEDCELPHSSYKNFM---------LLIEQLGMECKDSVSLLKIQD 1091
Cdd:TIGR00606  167 EGKALKQKFDEIFSATRYIKALETLRQVRQTQGQKVQEHQMELKYLKQYKekaceirdqITSKEAQLESSREIVKSYENE 246

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1092 AALSCERLLELKKNhcellTVKIKKMEDKVNVLQRELSETKEIKSQLEHQKVEwerELCSLRFSLNQEEEKRRNADTLYE 1171
Cdd:TIGR00606  247 LDPLKNRLKEIEHN-----LSKIMKLDNEIKALKSRKKQMEKDNSELELKMEK---VFQGTDEQLNDLYHNHQRTVREKE 318

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1172 KIREQLRRKEEQYRKEVEvkqqlELSLQTLEMELRTVKSNLNQVVQERNDAQRQLSREQNARMLQDGILTNHLSKQKEI- 1250
Cdd:TIGR00606  319 RELVDCQRELEKLNKERR-----LLNQEKTELLVEQGRLQLQADRHQEHIRARDSLIQSLATRLELDGFERGPFSERQIk 393

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1251 ---EMAQKKMNSENSHSHEEEKDLSHKNSMLQEEIAMLRLEI----DTIKNQNQEKEKKCfEDLKIVKEKNEDLQ---KT 1320
Cdd:TIGR00606  394 nfhTLVIERQEDEAKTAAQLCADLQSKERLKQEQADEIRDEKkglgRTIELKKEILEKKQ-EELKFVIKELQQLEgssDR 472

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1321 IKQNEETLTQTISQYNgrlsvLTAENAMLNSKLENEKqSKERLEAEVESYHSRLAAAIHDRDQSETSKRELEL------- 1393
Cdd:TIGR00606  473 ILELDQELRKAERELS-----KAEKNSLTETLKKEVK-SLQNEKADLDRKLRKLDQEMEQLNHHTTTRTQMEMltkdkmd 546

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1394 AFQRARDECSRLQDKMNFDVS-------------NLKDNNEILSQQLFKTESKLNSLEIEFHHTRDALREKTLGLERVQK 1460
Cdd:TIGR00606  547 KDEQIRKIKSRHSDELTSLLGyfpnkkqledwlhSKSKEINQTRDRLAKLNKELASLEQNKNHINNELESKEEQLSSYED 626

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1461 DLSQTqCQMKEMEQKYQNEQVKVNK-------YIGKQESVEERLSQLQSEN----------MLLRQQLDDAHNKADNKEK 1523
Cdd:TIGR00606  627 KLFDV-CGSQDEESDLERLKEEIEKsskqramLAGATAVYSQFITQLTDENqsccpvcqrvFQTEAELQEFISDLQSKLR 705

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1524 TVINIQDQFHAIVQKLQAESEKQSLLLEERNKEL---ISECNHLKERQYQYENEKAEREVVVRQLQQELADTLKKQSMSE 1600
Cdd:TIGR00606  706 LAPDKLKSTESELKKKEKRRDEMLGLAPGRQSIIdlkEKEIPELRNKLQKVNRDIQRLKNDIEEQETLLGTIMPEEESAK 785

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1601 ASL-EVTSRYRinLEDETQDLKKKLGQIRNQLQEAQ-DRHTEAVRcaEKMQDHKQKLEKDNAKLKVTVKKQMDKIEELQK 1678
Cdd:TIGR00606  786 VCLtDVTIMER--FQMELKDVERKIAQQAAKLQGSDlDRTVQQVN--QEKQEKQHELDTVVSKIELNRKLIQDQQEQIQH 861

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1679 NLLNANLSEDEKEQLKKLMELKQSLECNLDQEMKKNVELEREITGFKNLLKMTRKKLNEYENGEFSFHGDLKTSQFEMDI 1758
Cdd:TIGR00606  862 LKSKTNELKSEKLQIGTNLQRRQQFEEQLVELSTEVQSLIREIKDAKEQDSPLETFLEKDQQEKEELISSKETSNKKAQD 941

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1759 QINKLKHKIDDLTAELETAGSKClhLDTKNQILQEELLSMKTVQKKCEKLQKNKKKLEQEVINLR-----SHIERNMVEL 1833
Cdd:TIGR00606  942 KVNDIKEKVKNIHGYMKDIENKI--QDGKDDYLKQKETELNTVNAQLEECEKHQEKINEDMRLMRqdidtQKIQERWLQD 1019

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1834 GQVKQYKQEIEERARQEIAEKLKEVNlflQAQAASQENLEQFRENNFASMKSQMEL---RIKDLESEL--SKIKTSQEDF 1908
Cdd:TIGR00606 1020 NLTLRKRENELKEVEEELKQHLKEMG---QMQVLQMKQEHQKLEENIDLIKRNHVLalgRQKGYEKEIkhFKKELREPQF 1096

                          970       980
                   ....*....|....*....|....*...
gi 2462517825 1909 NKTElEKYKQLYLeELKVRKSLSSKLTK 1936
Cdd:TIGR00606 1097 RDAE-EKYREMMI-VMRTTELVNKDLDI 1122
SMC_N pfam02463
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
 1115-1965 4.16e-11

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


Pssm-ID: 426784 [Multi-domain]  Cd Length: 1161  Bit Score: 68.84  E-value: 4.16e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1115 KKMEDKVNVLQRELSETKEIKSQLEHQKVEwERELCSLRFSLNQEEEKRRNADTLYEKIREQLRRKEEQYRKEVEVKQQL 1194
Cdd:pfam02463  177 KLIEETENLAELIIDLEELKLQELKLKEQA-KKALEYYQLKEKLELEEEYLLYLDYLKLNEERIDLLQELLRDEQEEIES 255

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1195 ELSLQTLEMELRTVKSNLN-------QVVQERNDAQRQLSREQNARMLQDGILTNHLSKQKEIEMAQ-KKMNSENSHSHE 1266
Cdd:pfam02463  256 SKQEIEKEEEKLAQVLKENkeeekekKLQEEELKLLAKEEEELKSELLKLERRKVDDEEKLKESEKEkKKAEKELKKEKE 335

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1267 EEKDLSHKNSMLQEEIAMLRLEIDTIKNQNQEKEKKCFEDLKIVKEKNEDLQKTIKQNEETLT------QTISQYNGRLS 1340
Cdd:pfam02463  336 EIEELEKELKELEIKREAEEEEEEELEKLQEKLEQLEEELLAKKKLESERLSSAAKLKEEELElkseeeKEAQLLLELAR 415

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1341 VLTAENAMLNSKLENEKQSKERLEAEVESYHSRLAAAIHDRDQSETSKRELELAFQRARDECSRLQDKMNFDVSNLKDNN 1420
Cdd:pfam02463  416 QLEDLLKEEKKEELEILEEEEESIELKQGKLTEEKEELEKQELKLLKDELELKKSEDLLKETQLVKLQEQLELLLSRQKL 495

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1421 EILSQQLFKTESKLNSLEIEFHHTRDALREKTLGLERVQKDLSQTQCQMKEMEQKYQNEQVKVNKyIGKQESVEERLSQL 1500
Cdd:pfam02463  496 EERSQKESKARSGLKVLLALIKDGVGGRIISAHGRLGDLGVAVENYKVAISTAVIVEVSATADEV-EERQKLVRALTELP 574

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1501 QSENMLLRQQLDDAHNKADNKEKTViniqDQFHAIVQKLQAESEKQSLLLEERNKELISECnHLKERQYQYENEKAEREV 1580
Cdd:pfam02463  575 LGARKLRLLIPKLKLPLKSIAVLEI----DPILNLAQLDKATLEADEDDKRAKVVEGILKD-TELTKLKESAKAKESGLR 649

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1581 VVRQLQQELADTLKKQSMSEASLEVTSRYRINLEDETQDLKKKLGQIRNQLQEAQDRHTEavrcaEKMQDHKQKLEKDNA 1660
Cdd:pfam02463  650 KGVSLEEGLAEKSEVKASLSELTKELLEIQELQEKAESELAKEEILRRQLEIKKKEQREK-----EELKKLKLEAEELLA 724

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1661 KLKVTVKKQMDKIEELQKNLLNANLSEDEKEQLKKlMELKQSLECNLDQEMKKNVELEREITGFKNLLKMTRKKLNEYEN 1740
Cdd:pfam02463  725 DRVQEAQDKINEELKLLKQKIDEEEEEEEKSRLKK-EEKEEEKSELSLKEKELAEEREKTEKLKVEEEKEEKLKAQEEEL 803

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1741 GEFSFHGDLKTSQFEMDIQINKLKHKIDDLTAELetagskcLHLDTKNQILQEELLSMKT--VQKKCEKLQKNKKKLEQE 1818
Cdd:pfam02463  804 RALEEELKEEAELLEEEQLLIEQEEKIKEEELEE-------LALELKEEQKLEKLAEEELerLEEEITKEELLQELLLKE 876

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1819 VINLRSHIERNMVELGQVKQYKQEIEERARQEIAEKLKEVNLFLQAQAASQENLEQFREnnfasMKSQMELRIKDLESEL 1898
Cdd:pfam02463  877 EELEEQKLKDELESKEEKEKEEKKELEEESQKLNLLEEKENEIEERIKEEAEILLKYEE-----EPEELLLEEADEKEKE 951

                          810       820       830       840       850       860
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2462517825 1899 SKIKTSQEDFNKTELEKYKQLYLEELKVRKSLSSKLTKTNERLAEVNTKLLVEKQQSRSLFTTLTTR 1965
Cdd:pfam02463  952 ENNKEEEEERNKRLLLAKEELGKVNLMAIEEFEEKEERYNKDELEKERLEEEKKKLIRAIIEETCQR 1018
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
 1073-1636 5.89e-11

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 68.22  E-value: 5.89e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1073 IEQLGMECKDSVSLLKIQDAALSCERLLELKKNHCELLTVKIKKMEDKVNVLQRELSETKEIKS----QLEHQKVEWERE 1148
Cdd:pfam15921  278 VEITGLTEKASSARSQANSIQSQLEIIQEQARNQNSMYMRQLSDLESTVSQLRSELREAKRMYEdkieELEKQLVLANSE 357

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1149 LCSLRFSLNQEEEKRRNADTLYEKIREQLRRKEEQYRKEVEVKQQL---------------------ELSLQTLEMELRT 1207
Cdd:pfam15921  358 LTEARTERDQFSQESGNLDDQLQKLLADLHKREKELSLEKEQNKRLwdrdtgnsitidhlrrelddrNMEVQRLEALLKA 437

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1208 VKSNlnqvVQERNDAQRQLSREQNARMLQDGILTNHLSKQKEI------EMAQKKMNSENShsheeEKDLSHKNSMLQE- 1280
Cdd:pfam15921  438 MKSE----CQGQMERQMAAIQGKNESLEKVSSLTAQLESTKEMlrkvveELTAKKMTLESS-----ERTVSDLTASLQEk 508

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1281 ---------EIAMLRLEIDT-------IKNQN---QEKEKKCfEDLKIVKEKNEDLQKTIKQNEETLTQTISQYNGRLSV 1341
Cdd:pfam15921  509 eraieatnaEITKLRSRVDLklqelqhLKNEGdhlRNVQTEC-EALKLQMAEKDKVIEILRQQIENMTQLVGQHGRTAGA 587

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1342 LTAENAMLNSK-------------LENEKQSKER-LEAEV---ESYHSRLAAAIHDRDQS----ETSKRELELAFQRARD 1400
Cdd:pfam15921  588 MQVEKAQLEKEindrrlelqefkiLKDKKDAKIReLEARVsdlELEKVKLVNAGSERLRAvkdiKQERDQLLNEVKTSRN 667

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1401 ECSRLQDKMNFDVSNLKDNNEILSQQLFKTESKLNSLEIEFHHTRDALR----------------EKTLGLERVQKDLSQ 1464
Cdd:pfam15921  668 ELNSLSEDYEVLKRNFRNKSEEMETTTNKLKMQLKSAQSELEQTRNTLKsmegsdghamkvamgmQKQITAKRGQIDALQ 747

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1465 TQCQMKEMEQKYQNEQV-----KVNKYIGKQESVEERLSQLQSENMLLRQQLDDAHNKADNKEKTVINIQDQF---HAIV 1536
Cdd:pfam15921  748 SKIQFLEEAMTNANKEKhflkeEKNKLSQELSTVATEKNKMAGELEVLRSQERRLKEKVANMEVALDKASLQFaecQDII 827

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1537 QKLQAESEKQSLLLEERNKEL----ISECNHLKERQYQYENEKAEREVVVRQlqQELADTLKKQSMSEASLEvtsryrin 1612
Cdd:pfam15921  828 QRQEQESVRLKLQHTLDVKELqgpgYTSNSSMKPRLLQPASFTRTHSNVPSS--QSTASFLSHHSRKTNALK-------- 897

                          650       660
                   ....*....|....*....|....
gi 2462517825 1613 lEDETQDLKKKLGQIRNQLQEAQD 1636
Cdd:pfam15921  898 -EDPTRDLKQLLQELRSVINEEPT 920
SCP-1 pfam05483
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ...
 1173-1852 6.97e-11

Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.


Pssm-ID: 114219 [Multi-domain]  Cd Length: 787  Bit Score: 67.82  E-value: 6.97e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1173 IREQLRRKEEQYRKEVEVKQQLELSLQTLEMELRTVKSNLNQVVQERNDaqrqLSREQNARMLQDGILTNHLSKQKEiem 1252
Cdd:pfam05483   97 IEAELKQKENKLQENRKIIEAQRKAIQELQFENEKVSLKLEEEIQENKD----LIKENNATRHLCNLLKETCARSAE--- 169

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1253 AQKKMNSENSHSHEEEKDLSHKNSMLQEEIAMLRLEIDtikNQNQEKEKKCFEDLKIVKEKNEDLQKTIKQNEETLTQTI 1332
Cdd:pfam05483  170 KTKKYEYEREETRQVYMDLNNNIEKMILAFEELRVQAE---NARLEMHFKLKEDHEKIQHLEEEYKKEINDKEKQVSLLL 246

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1333 SQYNGRlsvltaENAM--LNSKLENEKQSKERLEAEVESYHSRLAAAIHDRDQSETSKRELELAFQRARDECSRLQDKMN 1410
Cdd:pfam05483  247 IQITEK------ENKMkdLTFLLEESRDKANQLEEKTKLQDENLKELIEKKDHLTKELEDIKMSLQRSMSTQKALEEDLQ 320

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1411 F---DVSNLKDNNEILSQQLFKTESKLNSLEIEFHHTRDALrEKTLGLERVQKDLSQTQCQMKEME-QKYQNEQVKVNKY 1486
Cdd:pfam05483  321 IatkTICQLTEEKEAQMEELNKAKAAHSFVVTEFEATTCSL-EELLRTEQQRLEKNEDQLKIITMElQKKSSELEEMTKF 399

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1487 IGKQESVEERLSQLQSENMLLRQQLDDAHNKADN--------------KEKTVINIQDQFHAI----------VQKLQAE 1542
Cdd:pfam05483  400 KNNKEVELEELKKILAEDEKLLDEKKQFEKIAEElkgkeqelifllqaREKEIHDLEIQLTAIktseehylkeVEDLKTE 479

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1543 SEKQSLlleeRNKELISECNHLKERQYQYENEKAEREVVVRQLQQELADTLKKQSMSEASLEVTSRYRINLEDETQDLKK 1622
Cdd:pfam05483  480 LEKEKL----KNIELTAHCDKLLLENKELTQEASDMTLELKKHQEDIINCKKQEERMLKQIENLEEKEMNLRDELESVRE 555

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1623 KLGQIRNQLQEAQDRHTEAVRCAEKMQDHKQKLEKDNAKLKVTVKKQmdkIEELQKNLlnANLSEDEKEQLKKLMELKQS 1702
Cdd:pfam05483  556 EFIQKGDEVKCKLDKSEENARSIEYEVLKKEKQMKILENKCNNLKKQ---IENKNKNI--EELHQENKALKKKGSAENKQ 630

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1703 LECNLDQEMKKNVELEREITGFKNLLKMTRKKLNEYENGEFSFHGDLKTSQFEMDIQIN-------KLKHKIDDLTAELE 1775
Cdd:pfam05483  631 LNAYEIKVNKLELELASAKQKFEEIIDNYQKEIEDKKISEEKLLEEVEKAKAIADEAVKlqkeidkRCQHKIAEMVALME 710

                          650       660       670       680       690       700       710
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2462517825 1776 TagskclHLDTKNQILQEELLSMKTVQKKCEKLQKNKKKLEQEVINLRSHIERNMVELGQVKQYKQEIEERARQEIA 1852
Cdd:pfam05483  711 K------HKHQYDKIIEERDSELGLYKNKEQEQSSAKAALEIELSNIKAELLSLKKQLEIEKEEKEKLKMEAKENTA 781
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
 1175-1927 7.08e-11

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 67.89  E-value: 7.08e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1175 EQLRRKEEQYRKEVEVKQQLELSLQTLEmelrtvkSNLNQVVQERNDAQRQL---------SREQNARMLQ-----DGIL 1240
Cdd:pfam01576    5 EEMQAKEEELQKVKERQQKAESELKELE-------KKHQQLCEEKNALQEQLqaetelcaeAEEMRARLAArkqelEEIL 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1241 TNHLSKQKEIEMAQKKMNSENSHSHEEEKDLSHKnsMLQEEIAMLRLEIDtiKNQNQEKEKKCFEDLKIVKEKNEDLQKT 1320
Cdd:pfam01576   78 HELESRLEEEEERSQQLQNEKKKMQQHIQDLEEQ--LDEEEAARQKLQLE--KVTTEAKIKKLEEDILLLEDQNSKLSKE 153

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1321 IKQNEEtltqtisqyngRLSVLTAENAMLNSKLENEKQSKERLEAEVESYHSRLAAAIHDRDQSETSKRELELAFQRARD 1400
Cdd:pfam01576  154 RKLLEE-----------RISEFTSNLAEEEEKAKSLSKLKNKHEAMISDLEERLKKEEKGRQELEKAKRKLEGESTDLQE 222

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1401 ECSRLQDKMnfdvsnlkdnnEILSQQLFKTESKLNSLEiefhhtrDALREKTLGLERVQKDLSQTQCQMKEMEQKYQNEQ 1480
Cdd:pfam01576  223 QIAELQAQI-----------AELRAQLAKKEEELQAAL-------ARLEEETAQKNNALKKIRELEAQISELQEDLESER 284

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1481 VKVNKYIGKQESVEERLSQLQSEnmlLRQQLDDAHNKAD---NKEKTVIN----IQDQFHAIVQKLQAESEKQSLLLEER 1553
Cdd:pfam01576  285 AARNKAEKQRRDLGEELEALKTE---LEDTLDTTAAQQElrsKREQEVTElkkaLEEETRSHEAQLQEMRQKHTQALEEL 361

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1554 NKELisecNHLKERQYQYENEKAEREVVVRQLQQELadtlkkQSMSEASLEVTSRyRINLEDETQDLKKKLGQIRNQLQE 1633
Cdd:pfam01576  362 TEQL----EQAKRNKANLEKAKQALESENAELQAEL------RTLQQAKQDSEHK-RKKLEGQLQELQARLSESERQRAE 430

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1634 AQDRHTEAVRCAEKMQDHKQKLEKDNAKLK---VTVKKQMDKIEELQKNLLNANLSEDEKeqLKKLMELKQSLECNLDQE 1710
Cdd:pfam01576  431 LAEKLSKLQSELESVSSLLNEAEGKNIKLSkdvSSLESQLQDTQELLQEETRQKLNLSTR--LRQLEDERNSLQEQLEEE 508

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1711 MKKNVELEREITGFKNLLKMTRKKLNEYENGEFSFHGDLKtsqfemdiqinKLKHKIDDLTAELETAGSKCLHLDTKNQI 1790
Cdd:pfam01576  509 EEAKRNVERQLSTLQAQLSDMKKKLEEDAGTLEALEEGKK-----------RLQRELEALTQQLEEKAAAYDKLEKTKNR 577

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1791 LQEEL--LSMKTVQKK--CEKLQKNKKKLEQEVINlrshiERNMVelgqvkqyKQEIEERARQEIAEKLKEVNlFLQAQA 1866
Cdd:pfam01576  578 LQQELddLLVDLDHQRqlVSNLEKKQKKFDQMLAE-----EKAIS--------ARYAEERDRAEAEAREKETR-ALSLAR 643

                          730       740       750       760       770       780
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462517825 1867 ASQENLEQfrennfasmKSQMELRIKDLESELSKIKTSQEDFNKT--ELEKYKQLY---LEELKVR 1927
Cdd:pfam01576  644 ALEEALEA---------KEELERTNKQLRAEMEDLVSSKDDVGKNvhELERSKRALeqqVEEMKTQ 700
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
1305-1877 7.33e-11

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 67.78  E-value: 7.33e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1305 EDLKIVKEKNEDLQKTIKQNEETLTQTISqyngRLSVLTAENAMLNSKLENEKQSKERLEAEVEsyhsRLAAAIHDRDQS 1384
Cdd:PRK03918   179 ERLEKFIKRTENIEELIKEKEKELEEVLR----EINEISSELPELREELEKLEKEVKELEELKE----EIEELEKELESL 250

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1385 ETSKRELELAFQRARDECSRLQDKMNFDVSNLKDNNEIlsQQLFKTESKLNSLEIEFhhtRDALREKTLGLERVQKDLSQ 1464
Cdd:PRK03918   251 EGSKRKLEEKIRELEERIEELKKEIEELEEKVKELKEL--KEKAEEYIKLSEFYEEY---LDELREIEKRLSRLEEEING 325

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1465 TQCQMKEMEQKyqneQVKVNKYIGKQESVEERLSQLQSENMLLrqqlDDAHNKADNKEKTVINIQDQfhaIVQKLQAESE 1544
Cdd:PRK03918   326 IEERIKELEEK----EERLEELKKKLKELEKRLEELEERHELY----EEAKAKKEELERLKKRLTGL---TPEKLEKELE 394

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1545 KqsllLEERNKELISECNHLKERQYQYENEKAEREVVVRQLQ----------QELADTLKKQSMSEASLEVTsryriNLE 1614
Cdd:PRK03918   395 E----LEKAKEEIEEEISKITARIGELKKEIKELKKAIEELKkakgkcpvcgRELTEEHRKELLEEYTAELK-----RIE 465

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1615 DETQDLKKKLGQIRNQLQE------AQDRHTEAVRCAEKMQDHKQKLEKDN-------AKLKVTVKKQMDKIEELQKNLl 1681
Cdd:PRK03918   466 KELKEIEEKERKLRKELRElekvlkKESELIKLKELAEQLKELEEKLKKYNleelekkAEEYEKLKEKLIKLKGEIKSL- 544

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1682 nanlsEDEKEQLKKLMELKQSLECNLDQEMKKNVELEREIT--GFKNL--LKMTRKKLNEYENGEFSfhgdLKTSQFEMD 1757
Cdd:PRK03918   545 -----KKELEKLEELKKKLAELEKKLDELEEELAELLKELEelGFESVeeLEERLKELEPFYNEYLE----LKDAEKELE 615

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1758 IQINKLKhkidDLTAELETAGSKCLHLDTKNQILQEEL--LSMKTVQKKCEKLQKNKKKLEQEVINLRSHIERNMVELGQ 1835
Cdd:PRK03918   616 REEKELK----KLEEELDKAFEELAETEKRLEELRKELeeLEKKYSEEEYEELREEYLELSRELAGLRAELEELEKRREE 691

                          570       580       590       600
                   ....*....|....*....|....*....|....*....|..
gi 2462517825 1836 VKQYKQEIEERaRQEIAEKLKEVNLFLQAQAASQENLEQFRE 1877
Cdd:PRK03918   692 IKKTLEKLKEE-LEEREKAKKELEKLEKALERVEELREKVKK 732
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 75-209 1.00e-10

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 66.44  E-value: 1.00e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825   75 DRDKMNrTALHLACANGHPEVVTLLVDRKCQLNVCDNENRTALMKAVQCQEEKCATILLEHGADPNLADVHGNTALHYAV 154
Cdd:PHA02878   164 DRHKGN-TALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGASTDARDKCGNTPLHISV 242

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 2462517825  155 -YNEDISVATKLLLYDANIEAKNK-DDLTPLLLAVsgKKQQMVEFLIKKKANVNAVD 209
Cdd:PHA02878   243 gYCKDYDILKLLLEHGVDVNAKSYiLGLTALHSSI--KSERKLKLLLEYGADINSLN 297
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 1178-1601 1.02e-10

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 67.40  E-value: 1.02e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1178 RRKEEQYRKEVEVKQQLELSLQTLEMELRTVKSNLNQVVQERNDAQRQLSReqnarmlqdgiltnhlsKQKEIEMAQKKM 1257
Cdd:TIGR02169  670 RSEPAELQRLRERLEGLKRELSSLQSELRRIENRLDELSQELSDASRKIGE-----------------IEKEIEQLEQEE 732

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1258 NSENshshEEEKDLSHKNSMLQEEIAMLRLEIDTIKNQNQEKEkkcfEDLKIVKEKNEDLqktikqneetltqtisqyng 1337
Cdd:TIGR02169  733 EKLK----ERLEELEEDLSSLEQEIENVKSELKELEARIEELE----EDLHKLEEALNDL-------------------- 784

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1338 rlsvltaENAMLNSKLENEKQSKErleaEVESYHSRLAAAIHDRDQsETSKRELELAFqrARDECSRLQDKMNfdvsNLK 1417
Cdd:TIGR02169  785 -------EARLSHSRIPEIQAELS----KLEEEVSRIEARLREIEQ-KLNRLTLEKEY--LEKEIQELQEQRI----DLK 846

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1418 DNNEILSQQLFKTESKLNSLEIEFHHTRDALREKTLGLERVQKDLSQTQCQMKEMEQKYQNEQVKVNKYIGKQESVEERL 1497
Cdd:TIGR02169  847 EQIKSIEKEIENLNGKKEELEEELEELEAALRDLESRLGDLKKERDELEAQLRELERKIEELEAQIEKKRKRLSELKAKL 926

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1498 SQLQSENmllrQQLDDAhNKADNKEKTVINIQDQFHAIVQKLQAESEKqsllLEERNKELISECNHLKERQYQYENEKAE 1577
Cdd:TIGR02169  927 EALEEEL----SEIEDP-KGEDEEIPEEELSLEDVQAELQRVEEEIRA----LEPVNMLAIQEYEEVLKRLDELKEKRAK 997

                          410       420
                   ....*....|....*....|....*.
gi 2462517825 1578 REVVVRQLQQELA--DTLKKQSMSEA 1601
Cdd:TIGR02169  998 LEEERKAILERIEeyEKKKREVFMEA 1023
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
1161-1729 1.49e-10

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 66.63  E-value: 1.49e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1161 EKRRNADTLYEKIREQLRRKEEQYRKEVEVKQQLELSLQTLEMELRTVKSNLNQVVQERNDAQRQLSR-EQNARMLQdgi 1239
Cdd:PRK03918   158 DDYENAYKNLGEVIKEIKRRIERLEKFIKRTENIEELIKEKEKELEEVLREINEISSELPELREELEKlEKEVKELE--- 234

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1240 ltnhlSKQKEIEMAQKKMNSENSHSHEEEKDLSHknsmLQEEIAMLRLEIDTIKNQNQE-----KEKKCFEDLKIVKEKN 1314
Cdd:PRK03918   235 -----ELKEEIEELEKELESLEGSKRKLEEKIRE----LEERIEELKKEIEELEEKVKElkelkEKAEEYIKLSEFYEEY 305

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1315 EDLQKTIKQNEETLTQTISQYNGRLSVLTAENAMLNSKLENEKQSKERLE----------------AEVESYHSRLAA-- 1376
Cdd:PRK03918   306 LDELREIEKRLSRLEEEINGIEERIKELEEKEERLEELKKKLKELEKRLEeleerhelyeeakakkEELERLKKRLTGlt 385

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1377 ---AIHDRDQSETSKRELELAFQRARDECSRLQDKmnfdVSNLKDNNEILSQQlfKTESKLNSLEIEFHHTRDALREKTL 1453
Cdd:PRK03918   386 pekLEKELEELEKAKEEIEEEISKITARIGELKKE----IKELKKAIEELKKA--KGKCPVCGRELTEEHRKELLEEYTA 459

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1454 GLERVQKDLSQTqcqmKEMEQKYQNEQVKVNKYIGKQ-------------ESVEERLSQLQSENM--------LLRQQLD 1512
Cdd:PRK03918   460 ELKRIEKELKEI----EEKERKLRKELRELEKVLKKEseliklkelaeqlKELEEKLKKYNLEELekkaeeyeKLKEKLI 535

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1513 DAHNKADNKEKTVINIQD---QFHAIVQKLQAESEKQSLLLEERNKELISECNHLKERQYQYEnEKAEREVVVRQLQQEL 1589
Cdd:PRK03918   536 KLKGEIKSLKKELEKLEElkkKLAELEKKLDELEEELAELLKELEELGFESVEELEERLKELE-PFYNEYLELKDAEKEL 614

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1590 ADTLKKQSMSEASLEVTsryrinlEDETQDLKKKLGQIRNQLQEAQDRHTEAVRcaEKMQDHKQKLEKDNAKLKVTVKKQ 1669
Cdd:PRK03918   615 EREEKELKKLEEELDKA-------FEELAETEKRLEELRKELEELEKKYSEEEY--EELREEYLELSRELAGLRAELEEL 685

                          570       580       590       600       610       620
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1670 MDKIEELQKNLlnanlsEDEKEQLKKLMELKQSLEcNLDQEMKKNVELEREITGFKNLLK 1729
Cdd:PRK03918   686 EKRREEIKKTL------EKLKEELEEREKAKKELE-KLEKALERVEELREKVKKYKALLK 738
DUF3584 pfam12128
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ...
 1109-1729 1.69e-10

Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.


Pssm-ID: 432349 [Multi-domain]  Cd Length: 1191  Bit Score: 66.79  E-value: 1.69e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1109 LLTVKIKKMEDKVNVLQRELSET-KEIKSQLEHQKVEWERELCSLRFSLNQEEEKRRNADTLYEKIREQLRRKE----EQ 1183
Cdd:pfam12128  262 HLHFGYKSDETLIASRQEERQETsAELNQLLRTLDDQWKEKRDELNGELSAADAAVAKDRSELEALEDQHGAFLdadiET 341

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1184 YRKEVEVKQQLELSLQTLEMELRTVKSNLNQVvQERNDAQRQLSREQNARMLQDgiLTNHLSKQKEIEMAQKKmnsensh 1263
Cdd:pfam12128  342 AAADQEQLPSWQSELENLEERLKALTGKHQDV-TAKYNRRRSKIKEQNNRDIAG--IKDKLAKIREARDRQLA------- 411

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1264 shEEEKDLSHKNSMLQEEIAMLRLEIdtikNQNQEKEKKCFEDLKIvkeknedLQKTIKQNEETLTQTisqyngrlsvlt 1343
Cdd:pfam12128  412 --VAEDDLQALESELREQLEAGKLEF----NEEEYRLKSRLGELKL-------RLNQATATPELLLQL------------ 466

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1344 aenAMLNSKLENEKQSKERLEAEVESYHSRLAAAIHDRDQSETSKRELELAFQRARDECSRLQDK-----------MNFD 1412
Cdd:pfam12128  467 ---ENFDERIERAREEQEAANAEVERLQSELRQARKRRDQASEALRQASRRLEERQSALDELELQlfpqagtllhfLRKE 543

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1413 VSNLKDN--NEILSQQLFKT-------------ESKLNSLEI--------EFHHTRDALREKtlgLERVQKDLSQTQCQM 1469
Cdd:pfam12128  544 APDWEQSigKVISPELLHRTdldpevwdgsvggELNLYGVKLdlkridvpEWAASEEELRER---LDKAEEALQSAREKQ 620

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1470 KEMEQkyqnEQVKVNKYIGKQESVEERLSQLQSENMLLRQQLDDAH-NKADNKEKTVINIQDQFHAIVQKLQAESE---- 1544
Cdd:pfam12128  621 AAAEE----QLVQANGELEKASREETFARTALKNARLDLRRLFDEKqSEKDKKNKALAERKDSANERLNSLEAQLKqldk 696

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1545 KQSLLLEERNKELISecnHLKERQYQYENEKAEREVVVRQLQQELA----------DTLKKQSMSE-ASLEVTSRYRINL 1613
Cdd:pfam12128  697 KHQAWLEEQKEQKRE---ARTEKQAYWQVVEGALDAQLALLKAAIAarrsgakaelKALETWYKRDlASLGVDPDVIAKL 773

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1614 EDETQDLKKKLGQIrnqlqeAQDRHteAVRCAEKMQDHKQKLEKDNakLKVTVKKQMDKIEELQKNLlnANLSEDEKEQL 1693
Cdd:pfam12128  774 KREIRTLERKIERI------AVRRQ--EVLRYFDWYQETWLQRRPR--LATQLSNIERAISELQQQL--ARLIADTKLRR 841

                          650       660       670
                   ....*....|....*....|....*....|....*.
gi 2462517825 1694 KKLMELKQSLEcnldqemKKNVELEREITGFKNLLK 1729
Cdd:pfam12128  842 AKLEMERKASE-------KQQVRLSENLRGLRCEMS 870
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 66-280 1.86e-10

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 66.43  E-value: 1.86e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825   66 LLLRKNGLNDRDKMNRTALHLAcANGHPEVVTLLVDRKCQLNVCDNENRTALMKAVQCQEEKCATILLEHGADPNLADVH 145
Cdd:PLN03192   512 LLGDNGGEHDDPNMASNLLTVA-STGNAALLEELLKAKLDPDIGDSKGRTPLHIAASKGYEDCVLVLLKHACNVHIRDAN 590

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825  146 GNTAL-------HYAVYN------------------------EDISVATKLLLYDANIEAKNKDDLTPLLLAVSGKKQQM 194
Cdd:PLN03192   591 GNTALwnaisakHHKIFRilyhfasisdphaagdllctaakrNDLTAMKELLKQGLNVDSEDHQGATALQVAMAEDHVDM 670

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825  195 VEFLIKKKANVNAVDKLES-SHQLISEYKEERIPKHSSQNSNSVDESSEDSLSRLSGKPGVDDSwpTSDDEdlnfdtKNV 273
Cdd:PLN03192   671 VRLLIMNGADVDKANTDDDfSPTELRELLQKRELGHSITIVDSVPADEPDLGRDGGSRPGRLQG--TSSDN------QCR 742


                   ....*..
gi 2462517825  274 PKPSLAK 280
Cdd:PLN03192   743 PRVSIYK 749
SMC_N pfam02463
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
 889-1758 2.78e-10

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


Pssm-ID: 426784 [Multi-domain]  Cd Length: 1161  Bit Score: 65.76  E-value: 2.78e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825  889 MLKVEFQALEKEKVQLQKEVEEERKKHRNNEMEVSANIHDGATDDAEDDDDDDGLIQKRKSgETDHQQFPRKENKEYASG 968
Cdd:pfam02463  202 LKEQAKKALEYYQLKEKLELEEEYLLYLDYLKLNEERIDLLQELLRDEQEEIESSKQEIEK-EEEKLAQVLKENKEEEKE 280

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825  969 PALQMKEVKSTEKEKRTSKESvnspvfgkasLLTGGLLQVDDDSSLSEIDEDEGRPTKKTSNEKNKVKNQIQSMDDVDDL 1048
Cdd:pfam02463  281 KKLQEEELKLLAKEEEELKSE----------LLKLERRKVDDEEKLKESEKEKKKAEKELKKEKEEIEELEKELKELEIK 350

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1049 TQSSETASEDCELphssyknfmLLIEQLGMECKDSVSLLKIQDAALSCERLLELKKnhcELLTVKIKKMEDKVNVLQREL 1128
Cdd:pfam02463  351 REAEEEEEEELEK---------LQEKLEQLEEELLAKKKLESERLSSAAKLKEEEL---ELKSEEEKEAQLLLELARQLE 418

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1129 SETKEIKSQLEHQKVEWERELCSLRFSLNQEEEKRRNADTLYEKIREQLRRKEEQYRKEVEVKQQLELSLQTLEMELRTV 1208
Cdd:pfam02463  419 DLLKEEKKEELEILEEEEESIELKQGKLTEEKEELEKQELKLLKDELELKKSEDLLKETQLVKLQEQLELLLSRQKLEER 498

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1209 KSNLnQVVQERNDAQRQLSREQNARMLQDGILTNHLSKQKEIEMAQKKMNSENSHSHEEEKDLSHKNSMLQEEIAMLRLE 1288
Cdd:pfam02463  499 SQKE-SKARSGLKVLLALIKDGVGGRIISAHGRLGDLGVAVENYKVAISTAVIVEVSATADEVEERQKLVRALTELPLGA 577

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1289 IDTIknqnQEKEKKCFEDLKIVKEKNEDLQKTIKQNEETLTqtisqyngrlsvltaenAMLNSKLENEKQSKERLEAEVE 1368
Cdd:pfam02463  578 RKLR----LLIPKLKLPLKSIAVLEIDPILNLAQLDKATLE-----------------ADEDDKRAKVVEGILKDTELTK 636

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1369 SYHSRLAAAIHDRDQSETSKRELELAFQRARDECSRLQDKmnfdvsNLKDNNEILSQQLFKTESKLNSLEIEFHHTRDAL 1448
Cdd:pfam02463  637 LKESAKAKESGLRKGVSLEEGLAEKSEVKASLSELTKELL------EIQELQEKAESELAKEEILRRQLEIKKKEQREKE 710

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1449 REKTLGLERVQKDLSQTQCQMKEMEQKYQNEQVKVNKYIGK-QESVEERLSQLQSENMLLRQQLDDAHNKADNKEKTVIN 1527
Cdd:pfam02463  711 ELKKLKLEAEELLADRVQEAQDKINEELKLLKQKIDEEEEEeEKSRLKKEEKEEEKSELSLKEKELAEEREKTEKLKVEE 790

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1528 IQDQFHAIVQKLQAESEKQSLLLEERNKELISECNHLKERQYQYENEKAEREVVVRQLQQELADTLKKQSMSEA-----S 1602
Cdd:pfam02463  791 EKEEKLKAQEEELRALEEELKEEAELLEEEQLLIEQEEKIKEEELEELALELKEEQKLEKLAEEELERLEEEITkeellQ 870

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1603 LEVTSRYRINLEDETQDLKKKLGQIRNQLQEAQDRHTEAV-------RCAEKMQDHKQKLEKDNAKLKVTVKKQMDKIEE 1675
Cdd:pfam02463  871 ELLLKEEELEEQKLKDELESKEEKEKEEKKELEEESQKLNlleekenEIEERIKEEAEILLKYEEEPEELLLEEADEKEK 950

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1676 LQKNLLNANLSEDEKEQLKKL---------MELKQSLECNLDQEMKKNVELEREITGFKNLLKMTRKKLNEYENGEFSFH 1746
Cdd:pfam02463  951 EENNKEEEEERNKRLLLAKEElgkvnlmaiEEFEEKEERYNKDELEKERLEEEKKKLIRAIIEETCQRLKEFLELFVSIN 1030

                          890
                   ....*....|..
gi 2462517825 1747 GDLKTSQFEMDI 1758
Cdd:pfam02463 1031 KGWNKVFFYLEL 1042
SCP-1 pfam05483
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ...
 1268-1958 3.24e-10

Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.


Pssm-ID: 114219 [Multi-domain]  Cd Length: 787  Bit Score: 65.51  E-value: 3.24e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1268 EKDLSHKNSMLQEEIAMLRLEIDTIKNQNQEKEKKCFEDLKIVKEkNEDLqktIKQNEETltqtiSQYNGRLSVLTAENA 1347
Cdd:pfam05483   98 EAELKQKENKLQENRKIIEAQRKAIQELQFENEKVSLKLEEEIQE-NKDL---IKENNAT-----RHLCNLLKETCARSA 168

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1348 MLNSKLENEKQSKERLEAEVESYHSRLAAAIHD-RDQSETSKRELELAFQRARDECSRLQDKMNFDVSNLKDNNEILSQQ 1426
Cdd:pfam05483  169 EKTKKYEYEREETRQVYMDLNNNIEKMILAFEElRVQAENARLEMHFKLKEDHEKIQHLEEEYKKEINDKEKQVSLLLIQ 248

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1427 LFKTESKLNSLEIEFHHTRDALREKTLGLERVQKDLSQTQCQMKEMEQKYQNEQVKVNKYIGKQESVEERLSQlqsenml 1506
Cdd:pfam05483  249 ITEKENKMKDLTFLLEESRDKANQLEEKTKLQDENLKELIEKKDHLTKELEDIKMSLQRSMSTQKALEEDLQI------- 321

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1507 lrqqlddahnkadnKEKTVINIQDQFHAIVQKLQAESEKQSLLLEERNKELISECNHLKERQYQYENEKAEREVVVRQLQ 1586
Cdd:pfam05483  322 --------------ATKTICQLTEEKEAQMEELNKAKAAHSFVVTEFEATTCSLEELLRTEQQRLEKNEDQLKIITMELQ 387

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1587 QEladtlkkqsmsEASLEVTSRYRINLEDETQDLKKKLGQIRNQLQEAQdrhtEAVRCAEKMQDHKQKL---------EK 1657
Cdd:pfam05483  388 KK-----------SSELEEMTKFKNNKEVELEELKKILAEDEKLLDEKK----QFEKIAEELKGKEQELifllqarekEI 452

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1658 DNAKLKVTVKKQMDK-----IEELQKNLLNANLSEDEKEQLKKLMELKQSlecNLDQEMKKNV-ELEREITGFKNLLKMT 1731
Cdd:pfam05483  453 HDLEIQLTAIKTSEEhylkeVEDLKTELEKEKLKNIELTAHCDKLLLENK---ELTQEASDMTlELKKHQEDIINCKKQE 529

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1732 RKKLNEYEN---GEFSFHGDLKTSQFEMDIQINKLKHKIDDLTAELETAGSKCLHLDTKNQILQEELLSMKtvqKKCEKL 1808
Cdd:pfam05483  530 ERMLKQIENleeKEMNLRDELESVREEFIQKGDEVKCKLDKSEENARSIEYEVLKKEKQMKILENKCNNLK---KQIENK 606

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1809 QKNKKKLEQE--VINLRSHIERNMVELGQVKQYKQEIE-ERARQEIAEKLKEVNLFLQAQAASQENL----EQFRENNFA 1881
Cdd:pfam05483  607 NKNIEELHQEnkALKKKGSAENKQLNAYEIKVNKLELElASAKQKFEEIIDNYQKEIEDKKISEEKLleevEKAKAIADE 686

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1882 SMKSQMEL------RIKDLESELSKIKTSQEDF---NKTELEKYKQLYLEELKVRKSLSSKLTKTNERLAEVNTKLLVEK 1952
Cdd:pfam05483  687 AVKLQKEIdkrcqhKIAEMVALMEKHKHQYDKIieeRDSELGLYKNKEQEQSSAKAALEIELSNIKAELLSLKKQLEIEK 766


                   ....*.
gi 2462517825 1953 QQSRSL 1958
Cdd:pfam05483  767 EEKEKL 772
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 39-214 7.90e-10

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 64.31  E-value: 7.90e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825   39 GYHVRDRDLGK---IHKAASAGNVAKVQQILLLRKNGLNDRDKMNRTALHLACANGH-PEVVTLLVDRKCQLNVCDNENR 114
Cdd:PHA02876   263 GFSVNSIDDCKntpLHHASQAPSLSRLVPKLLERGADVNAKNIKGETPLYLMAKNGYdTENIRTLIMLGADVNAADRLYI 342

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825  115 TALMKAVQCQEEKCATI-LLEHGADPNLADVHGNTALHYAVYNEDISVATKLLLYDANIEAKNKDDLTPLLLAVSGKKQQ 193
Cdd:PHA02876   343 TPLHQASTLDRNKDIVItLLELGANVNARDYCDKTPIHYAAVRNNVVIINTLLDYGADIEALSQKIGTALHFALCGTNPY 422

                          170       180
                   ....*....|....*....|..
gi 2462517825  194 M-VEFLIKKKANVNAVDKLESS 214
Cdd:PHA02876   423 MsVKTLIDRGANVNSKNKDLST 444
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 125-210 1.09e-09

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 63.36  E-value: 1.09e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825  125 EEKCATILLEHGADPNLADVH-GNTALHYAVYNEDISVATKLLLYDANIEAKNKDDLTPLLLAVSGKKQQMVEFLIKKKA 203
Cdd:PHA02878   146 EAEITKLLLSYGADINMKDRHkGNTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGA 225


                   ....*..
gi 2462517825  204 NVNAVDK 210
Cdd:PHA02878   226 STDARDK 232
PHA03095 PHA03095
ankyrin-like protein; Provisional
 55-179 1.88e-09

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 62.35  E-value: 1.88e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825   55 SAGNVAKVqqILLLRKNG--LNDRDKMNRTALHL-ACANGHPEVVTLLVDRKCQLNVCDNENRTALMK--AVQCQEEKCA 129
Cdd:PHA03095    58 SSEKVKDI--VRLLLEAGadVNAPERCGFTPLHLyLYNATTLDVIKLLIKAGADVNAKDKVGRTPLHVylSGFNINPKVI 135

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|
gi 2462517825  130 TILLEHGADPNLADVHGNTALHYAVYNEDISVATKLLLYDANIEAKNKDD 179
Cdd:PHA03095   136 RLLLRKGADVNALDLYGMTPLAVLLKSRNANVELLRLLIDAGADVYAVDD 185
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
1388-1944 2.97e-09

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 62.39  E-value: 2.97e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1388 KRELELAFQRARDECSRLQDkmnfdVSNLKDNNEilsQQLFKTESKLNSLEIEfhhtRDALREKTLGLERVQKDLsqtqc 1467
Cdd:PRK03918   171 IKEIKRRIERLEKFIKRTEN-----IEELIKEKE---KELEEVLREINEISSE----LPELREELEKLEKEVKEL----- 233

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1468 qmKEMEQKYQNEQVKVNKYIGKQESVEERLSQLQSENMLLRQQLDDAHNKAdnKEKTVINIQDQFHAIVQKLQAESEKQS 1547
Cdd:PRK03918   234 --EELKEEIEELEKELESLEGSKRKLEEKIRELEERIEELKKEIEELEEKV--KELKELKEKAEEYIKLSEFYEEYLDEL 309

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1548 LLLEERNKELISECNHLKERQYQYENEKAErevvVRQLQQELADTLKKQSMSEASLEVTSRYRiNLEDETQDLKKKLGQi 1627
Cdd:PRK03918   310 REIEKRLSRLEEEINGIEERIKELEEKEER----LEELKKKLKELEKRLEELEERHELYEEAK-AKKEELERLKKRLTG- 383

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1628 rNQLQEAQDRHTEAVRCAEKMQDHKQKLEKDNAKLKVTVKKQMDKIEELQKN-----LLNANLSEDEKEQL--------K 1694
Cdd:PRK03918   384 -LTPEKLEKELEELEKAKEEIEEEISKITARIGELKKEIKELKKAIEELKKAkgkcpVCGRELTEEHRKELleeytaelK 462

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1695 KLMELKQSLECNLDQEMKKNVELEREITGFKNLLKMtRKKLNEYENGEFSFHGdlktsqfemdIQINKLKHKiddlTAEL 1774
Cdd:PRK03918   463 RIEKELKEIEEKERKLRKELRELEKVLKKESELIKL-KELAEQLKELEEKLKK----------YNLEELEKK----AEEY 527

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1775 ETAGSKCLHLDTKNQILQEELLSMKTVQKKCEKLQKNKKKLEQEVINLRSHIERNMVE-LGQVKQYKQEIEERARQEIae 1853
Cdd:PRK03918   528 EKLKEKLIKLKGEIKSLKKELEKLEELKKKLAELEKKLDELEEELAELLKELEELGFEsVEELEERLKELEPFYNEYL-- 605

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1854 KLKEVNLFLQAQAASQENLEQFRENNFAsmksQMELRIKDLESELSKIKTSQEDFNKTELEKYKQLYLEELKVRKSLSSK 1933
Cdd:PRK03918   606 ELKDAEKELEREEKELKKLEEELDKAFE----ELAETEKRLEELRKELEELEKKYSEEEYEELREEYLELSRELAGLRAE 681

                          570
                   ....*....|.
gi 2462517825 1934 LTKTNERLAEV 1944
Cdd:PRK03918   682 LEELEKRREEI 692
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 50-214 2.97e-09

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 61.60  E-value: 2.97e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825   50 IHKAASAGNVAKVQQILllrKNG--LNDRDKMNRTALHLACANGH-----PEVVTLLVDRKCQLNVCDNENRTALMKAVQ 122
Cdd:PHA03100    39 LYLAKEARNIDVVKILL---DNGadINSSTKNNSTPLHYLSNIKYnltdvKEIVKLLLEYGANVNAPDNNGITPLLYAIS 115

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825  123 CQEEKCATI--LLEHGADPNLADVHGNTALHYAV---------------YNEDISVATK---LLLYDANIEAKNKDDLTP 182
Cdd:PHA03100   116 KKSNSYSIVeyLLDNGANVNIKNSDGENLLHLYLesnkidlkilkllidKGVDINAKNRvnyLLSYGVPINIKDVYGFTP 195

                          170       180       190
                   ....*....|....*....|....*....|..
gi 2462517825  183 LLLAVSGKKQQMVEFLIKKKANVNAVDKLESS 214
Cdd:PHA03100   196 LHYAVYNNNPEFVKYLLDLGANPNLVNKYGDT 227
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 50-211 3.39e-09

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 62.00  E-value: 3.39e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825   50 IHKAASAGNvAKVQQILLLRKNGLNDRDKMNRTALHLACANGHPEVVTLLVDRKCQLNvcdnENRTALMKAVQCQEEKCA 129
Cdd:PHA02876   182 IHYAAERGN-AKMVNLLLSYGADVNIIALDDLSVLECAVDSKNIDTIKAIIDNRSNIN----KNDLSLLKAIRNEDLETS 256

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825  130 TILLEHGADPNLADVHGNTALHYAVYNEDIS-VATKLLLYDANIEAKNKDDLTPL-LLAVSGKKQQMVEFLIKKKANVNA 207
Cdd:PHA02876   257 LLLYDAGFSVNSIDDCKNTPLHHASQAPSLSrLVPKLLERGADVNAKNIKGETPLyLMAKNGYDTENIRTLIMLGADVNA 336


                   ....
gi 2462517825  208 VDKL 211
Cdd:PHA02876   337 ADRL 340
PHA03095 PHA03095
ankyrin-like protein; Provisional
 50-209 5.17e-09

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 61.19  E-value: 5.17e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825   50 IHKAASAGNVAKVQQiLLLRKNG-LNDRDKMNRTALH--LACANGHPEVVTLLVDRKCQLNVCDNENRT---ALMKAVQC 123
Cdd:PHA03095    87 LHLYLYNATTLDVIK-LLIKAGAdVNAKDKVGRTPLHvyLSGFNINPKVIRLLLRKGADVNALDLYGMTplaVLLKSRNA 165

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825  124 QEE----------------------------------KCATILLEHGADPNLADVHGNTALHYAVYNEDI--SVATKLLL 167
Cdd:PHA03095   166 NVEllrllidagadvyavddrfrsllhhhlqsfkpraRIVRELIRAGCDPAATDMLGNTPLHSMATGSSCkrSLVLPLLI 245

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|..
gi 2462517825  168 YDANIEAKNKDDLTPLLLAVSGKKQQMVEFLIKKKANVNAVD 209
Cdd:PHA03095   246 AGISINARNRYGQTPLHYAAVFNNPRACRRLIALGADINAVS 287
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 129-282 1.13e-08

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 60.30  E-value: 1.13e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825  129 ATILLEHGADPNLADVHGNTALHYAVYNEDISVATKLLLYDANIEAKNKDDLTPLLLAVSGKKQQMVeflikkkanvnav 208
Cdd:PTZ00322    98 ARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVV------------- 164

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2462517825  209 dklesshQLISEYKEEripkHSSQNSNSVDESsedslsrLSGKPGVDDSWPTSDDEDlnfDTKNVPKPSLAKLM 282
Cdd:PTZ00322   165 -------QLLSRHSQC----HFELGANAKPDS-------FTGKPPSLEDSPISSHHP---DFSAVPQPMMGSLI 217
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
1091-1641 1.20e-08

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 60.44  E-value: 1.20e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1091 DAALSCERLLELKKNHCELLTVKIKKMEDK-----VNVLQRELSETKEIKSQLEHQKVEWERELCSLRFSLNQEEEKRRN 1165
Cdd:PRK02224   173 DARLGVERVLSDQRGSLDQLKAQIEEKEEKdlherLNGLESELAELDEEIERYEEQREQARETRDEADEVLEEHEERREE 252

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1166 ADTLYEKIRE------QLRRKEEQYRKEVEVKQQLELSLQTLEMELRTvKSNLNQVVQERNDAQRQ-LSREQNArmLQDG 1238
Cdd:PRK02224   253 LETLEAEIEDlretiaETEREREELAEEVRDLRERLEELEEERDDLLA-EAGLDDADAEAVEARREeLEDRDEE--LRDR 329

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1239 ILtnhlskqkEIEMAQKKMNSENSHSHEEEKDLSHKNSMLQEEIAMLRLEIDTIKnqnqekekkcfEDLKIVKEKNEDLQ 1318
Cdd:PRK02224   330 LE--------ECRVAAQAHNEEAESLREDADDLEERAEELREEAAELESELEEAR-----------EAVEDRREEIEELE 390

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1319 KTIKQNEETLTQTISQYNGrlsvLTAENAMLNSKLENEKQSKERLEAEVESYHSRLAAA---------------IHDR-- 1381
Cdd:PRK02224   391 EEIEELRERFGDAPVDLGN----AEDFLEELREERDELREREAELEATLRTARERVEEAealleagkcpecgqpVEGSph 466

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1382 ----DQSETSKRELELAFQRARDECSRLQDKMNfdvsnlkdnneiLSQQLFKTESKLNSLE---------IEFHHTRDAL 1448
Cdd:PRK02224   467 vetiEEDRERVEELEAELEDLEEEVEEVEERLE------------RAEDLVEAEDRIERLEerredleelIAERRETIEE 534

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1449 REKTLGLERVQKDLSQTQCQMK-----EMEQKYQNEQVKVNKYIGKQESVEERLSQLQSenmlLRQQLDDAHNKADN--- 1520
Cdd:PRK02224   535 KRERAEELRERAAELEAEAEEKreaaaEAEEEAEEAREEVAELNSKLAELKERIESLER----IRTLLAAIADAEDEier 610

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1521 ---KEKTVINIQDQFHaivQKLQAESEKQSLLLEERNKELISECNHLKERQYQYENEKAERevvVRQLQQELADTLKKQS 1597
Cdd:PRK02224   611 lreKREALAELNDERR---ERLAEKRERKRELEAEFDEARIEEAREDKERAEEYLEQVEEK---LDELREERDDLQAEIG 684

                          570       580       590       600
                   ....*....|....*....|....*....|....*....|....
gi 2462517825 1598 MSEASLEvtsryrinledETQDLKKKLGQIRNQLQEAQDRHTEA 1641
Cdd:PRK02224   685 AVENELE-----------ELEELRERREALENRVEALEALYDEA 717
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 73-218 4.27e-08

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 58.05  E-value: 4.27e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825   73 LNDRDKMNRTALHLACANGHPEVVTLLVDRKCQLNVCDNENRTALMKAVQCQEEKCATILLEHGADPNLADVHGNTALHY 152
Cdd:PHA02874   117 VNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVKDNNGESPLHN 196

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2462517825  153 AVYNEDISVATKLLLYDANIEAKNKDDLTPLLLAVSgKKQQMVEFLIKKKA-NVNAVDKLESSHQLI 218
Cdd:PHA02874   197 AAEYGDYACIKLLIDHGNHIMNKCKNGFTPLHNAII-HNRSAIELLINNASiNDQDIDGSTPLHHAI 262
rad50 TIGR00606
rad50; All proteins in this family for which functions are known are involvedin recombination, ...
 1128-1964 4.68e-08

rad50; All proteins in this family for which functions are known are involvedin recombination, recombinational repair, and/or non-homologous end joining.They are components of an exonuclease complex with MRE11 homologs. This family is distantly related to the SbcC family of bacterial proteins.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).


Pssm-ID: 129694 [Multi-domain]  Cd Length: 1311  Bit Score: 58.52  E-value: 4.68e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1128 LSETKEIKSQLEH-----QKVEWERELCSLRFSLNQEEEKRRNADTLYEK-------IREQLRRKEEQYRKEVEVKQQLE 1195
Cdd:TIGR00606  165 LSEGKALKQKFDEifsatRYIKALETLRQVRQTQGQKVQEHQMELKYLKQykekaceIRDQITSKEAQLESSREIVKSYE 244

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1196 LSLQTLEMELRTVKSNLNQVVQERND----AQRQLSREQNARMLQ--------------DGILTNHLSKQKEIEMAQKKM 1257
Cdd:TIGR00606  245 NELDPLKNRLKEIEHNLSKIMKLDNEikalKSRKKQMEKDNSELElkmekvfqgtdeqlNDLYHNHQRTVREKERELVDC 324

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1258 NSENSHSHEEEKDLSHKNSMLQEEIAMLRLEIDTIKNQNQEK----------------EKKCFEDLKI------VKEKNE 1315
Cdd:TIGR00606  325 QRELEKLNKERRLLNQEKTELLVEQGRLQLQADRHQEHIRARdsliqslatrleldgfERGPFSERQIknfhtlVIERQE 404

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1316 DLQKTIKQNEETLTQTISQYNGRLSVLTAENAMLNSKLENEkqsKERLEAEVEsyhsRLAAAIHDRDQSETSKR---ELE 1392
Cdd:TIGR00606  405 DEAKTAAQLCADLQSKERLKQEQADEIRDEKKGLGRTIELK---KEILEKKQE----ELKFVIKELQQLEGSSDrilELD 477

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1393 LAFQRARDECSRLQDKMNfdvsnlkdnneilSQQLFKTESKLNSLEIEFHHTRDALREKTLGLERVQKDLSQTQCQMKEM 1472
Cdd:TIGR00606  478 QELRKAERELSKAEKNSL-------------TETLKKEVKSLQNEKADLDRKLRKLDQEMEQLNHHTTTRTQMEMLTKDK 544

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1473 EQKYQneQVKVNKYIGKQESVEerlsqlQSENMLLRQQLDDAHNKADNKektvINIQDQFHAIVQKLQAESEKQSLLLEE 1552
Cdd:TIGR00606  545 MDKDE--QIRKIKSRHSDELTS------LLGYFPNKKQLEDWLHSKSKE----INQTRDRLAKLNKELASLEQNKNHINN 612

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1553 RNKELISECNHLKERQYQYENEKAErEVVVRQLQQELADTLKKQSMSEASLEVTSRYRINLEDETQD---LKKKLGQIRN 1629
Cdd:TIGR00606  613 ELESKEEQLSSYEDKLFDVCGSQDE-ESDLERLKEEIEKSSKQRAMLAGATAVYSQFITQLTDENQSccpVCQRVFQTEA 691

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1630 QLQEAQDRHTEAVRCA----EKMQDHKQKLEKDNAKLKVTVKKQMDKIEELQKNLlnANLSEDEKEQLKKLMELKQSLEC 1705
Cdd:TIGR00606  692 ELQEFISDLQSKLRLApdklKSTESELKKKEKRRDEMLGLAPGRQSIIDLKEKEI--PELRNKLQKVNRDIQRLKNDIEE 769

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1706 NLDQEMKKNVELERE---------ITGFKNLLKMTRKKLNEYENGEFSFHGDLKTSQF-----EMDIQINKLKHKIDDLT 1771
Cdd:TIGR00606  770 QETLLGTIMPEEESAkvcltdvtiMERFQMELKDVERKIAQQAAKLQGSDLDRTVQQVnqekqEKQHELDTVVSKIELNR 849

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1772 AELETAGSKCLHLDTKNQILQEELLSMKTVQKKCEKLQKNKKKLEQEVINLRSHIERNMVELGQVKQYKQEIEERARQEI 1851
Cdd:TIGR00606  850 KLIQDQQEQIQHLKSKTNELKSEKLQIGTNLQRRQQFEEQLVELSTEVQSLIREIKDAKEQDSPLETFLEKDQQEKEELI 929

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1852 AEK---LKEVNLFLQAQAASQENLEQFRENNFASMKSQMELRIKDLESELSKIKTSQEdfnktELEKYKQLYLEELKVRK 1928
Cdd:TIGR00606  930 SSKetsNKKAQDKVNDIKEKVKNIHGYMKDIENKIQDGKDDYLKQKETELNTVNAQLE-----ECEKHQEKINEDMRLMR 1004

                          890       900       910
                   ....*....|....*....|....*....|....*.
gi 2462517825 1929 SlSSKLTKTNERLAEVNTKLLVEKQQSRSLFTTLTT 1964
Cdd:TIGR00606 1005 Q-DIDTQKIQERWLQDNLTLRKRENELKEVEEELKQ 1039
SCP-1 pfam05483
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ...
 1107-1720 6.04e-08

Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.


Pssm-ID: 114219 [Multi-domain]  Cd Length: 787  Bit Score: 58.19  E-value: 6.04e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1107 CELLTVKIKKMEDKVNVLQRELSETKEIKSQLEHQKVEWERELCSLRFslnQEEEKRRNADTLYEKIREQLRRKEEQYRK 1186
Cdd:pfam05483  157 CNLLKETCARSAEKTKKYEYEREETRQVYMDLNNNIEKMILAFEELRV---QAENARLEMHFKLKEDHEKIQHLEEEYKK 233

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1187 EVEVKQQLELSLQTLEMELRTVKSNLNQVVQERNDAQRQLSREQNarmLQDGILTNHLSKQKEIEMAQKKMNSENSHSHE 1266
Cdd:pfam05483  234 EINDKEKQVSLLLIQITEKENKMKDLTFLLEESRDKANQLEEKTK---LQDENLKELIEKKDHLTKELEDIKMSLQRSMS 310

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1267 EEKDLSHKNSMLQEEIAMLRLEidtiKNQNQEKEKKCFEDLKIVKEKNEDLQKTIKQNEETLTQTISQYNGRLSVLTAEN 1346
Cdd:pfam05483  311 TQKALEEDLQIATKTICQLTEE----KEAQMEELNKAKAAHSFVVTEFEATTCSLEELLRTEQQRLEKNEDQLKIITMEL 386

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1347 AMLNSKLENEKQSKERLEAEVESYHSRLA---AAIHDRDQSET-------SKRELELAFQRARDECSRLQdkmnFDVSNL 1416
Cdd:pfam05483  387 QKKSSELEEMTKFKNNKEVELEELKKILAedeKLLDEKKQFEKiaeelkgKEQELIFLLQAREKEIHDLE----IQLTAI 462

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1417 KDNNEILSQQL--FKTE---SKLNSLEIEFHHTRDALREK---------TLGLERVQKDLSQTQCQMKEMEQKYQNEQVK 1482
Cdd:pfam05483  463 KTSEEHYLKEVedLKTElekEKLKNIELTAHCDKLLLENKeltqeasdmTLELKKHQEDIINCKKQEERMLKQIENLEEK 542

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1483 VNKYIGKQESVEERLSQLQSEnmlLRQQLDDAHNKADNKEKTVINIQDQFHAIVQK---LQAESEKQSLLLEernkELIS 1559
Cdd:pfam05483  543 EMNLRDELESVREEFIQKGDE---VKCKLDKSEENARSIEYEVLKKEKQMKILENKcnnLKKQIENKNKNIE----ELHQ 615

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1560 ECNHLKERQYQYENEKAEREVVVRQLQQELADTLKKQSmseaslEVTSRYRINLEDETQDLKKKLGQIrnqlQEAQDRHT 1639
Cdd:pfam05483  616 ENKALKKKGSAENKQLNAYEIKVNKLELELASAKQKFE------EIIDNYQKEIEDKKISEEKLLEEV----EKAKAIAD 685

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1640 EAVRCAEKMQDHKQKLEKDNAKLKVTVKKQMDKI-EELQKNLLNANLSEDEKEQLKKLMELKQSLECNLDQEMKKNVELE 1718
Cdd:pfam05483  686 EAVKLQKEIDKRCQHKIAEMVALMEKHKHQYDKIiEERDSELGLYKNKEQEQSSAKAALEIELSNIKAELLSLKKQLEIE 765


                   ..
gi 2462517825 1719 RE 1720
Cdd:pfam05483  766 KE 767
HCR pfam07111
Alpha helical coiled-coil rod protein (HCR); This family consists of several mammalian alpha ...
 1175-1719 7.59e-08

Alpha helical coiled-coil rod protein (HCR); This family consists of several mammalian alpha helical coiled-coil rod HCR proteins. The function of HCR is unknown but it has been implicated in psoriasis in humans and is thought to affect keratinocyte proliferation.


Pssm-ID: 284517 [Multi-domain]  Cd Length: 749  Bit Score: 57.84  E-value: 7.59e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1175 EQLRRKEEQYR--KEVEVKQQLELSLQTLEME---------------LRT-------VKSNLNQVVQERNDAQRQLSREQ 1230
Cdd:pfam07111   73 QELRRLEEEVRllRETSLQQKMRLEAQAMELDalavaekagqaeaegLRAalagaemVRKNLEEGSQRELEEIQRLHQEQ 152

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1231 NARMLQ--DGILTNHLSKQKEIEmaqKKMNSENSHSHEEEKDLshknSMLQEEIAMLRLEIDTIKnQNQEKEKKCFEDLK 1308
Cdd:pfam07111  153 LSSLTQahEEALSSLTSKAEGLE---KSLNSLETKRAGEAKQL----AEAQKEAELLRKQLSKTQ-EELEAQVTLVESLR 224

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1309 -----------------IVKEKNEDLQKTIKQNEETLTQTISQYNGRLSVLTAENAMLNSKLENEKQSKERLEAE----- 1366
Cdd:pfam07111  225 kyvgeqvppevhsqtweLERQELLDTMQHLQEDRADLQATVELLQVRVQSLTHMLALQEEELTRKIQPSDSLEPEfpkkc 304

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1367 ---VESYHSRLAAAIHDRDQSETSKRElelAFQRARDECSRLQDKmnfdVSNLKDNNEILSQQLFKTESKL-------NS 1436
Cdd:pfam07111  305 rslLNRWREKVFALMVQLKAQDLEHRD---SVKQLRGQVAELQEQ----VTSQSQEQAILQRALQDKAAEVevermsaKG 377

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1437 LEIEFHHTRDALREKTLGLERVQKDLSQTQCQMKEMEQKYQNEQVKVNKYIGKQESVEERLSQlqsenmllrqqlddahn 1516
Cdd:pfam07111  378 LQMELSRAQEARRRQQQQTASAEEQLKFVVNAMSSTQIWLETTMTRVEQAVARIPSLSNRLSY----------------- 440

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1517 kADNKEKTVINIQDQFHAIVQkLQAESEKQSLLLEERNKELISECNHLKERQYQYEnekAEREVVVRQLQQELAdtlKKQ 1596
Cdd:pfam07111  441 -AVRKVHTIKGLMARKVALAQ-LRQESCPPPPPAPPVDADLSLELEQLREERNRLD---AELQLSAHLIQQEVG---RAR 512

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1597 SMSEASLEVTSRYRINLEDETQDLKKKLGQIRNQLQEAQDRHTEAVRCA--------EKMQDHKQKLEKDNAKLKVTVKK 1668
Cdd:pfam07111  513 EQGEAERQQLSEVAQQLEQELQRAQESLASVGQQLEVARQGQQESTEEAaslrqeltQQQEIYGQALQEKVAEVETRLRE 592

                          570       580       590       600       610
                   ....*....|....*....|....*....|....*....|....*....|.
gi 2462517825 1669 QMDKIEElqknllnaNLSEDEKEQLKKLMELKQsLECNLDQEMKKNVELER 1719
Cdd:pfam07111  593 QLSDTKR--------RLNEARREQAKAVVSLRQ-IQHRATQEKERNQELRR 634
Ank_2 pfam12796
Ankyrin repeats (3 copies);
150-210 8.25e-08

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 51.66  E-value: 8.25e-08
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462517825  150 LHYAVYNEDISVATKLLLYDANIEAKNKDDLTPLLLAVSGKKQQMVEFLIkKKANVNAVDK 210
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLL-EHADVNLKDN 60
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 1622-1962 2.22e-07

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 56.48  E-value: 2.22e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1622 KKLGQIRNQLQEAQDRHTEavrcaekMQDHKQKLEKDnAKLKVTVKKQMDKIEELQKNLLNANLsEDEKEQLKKLMELKQ 1701
Cdd:COG1196    179 RKLEATEENLERLEDILGE-------LERQLEPLERQ-AEKAERYRELKEELKELEAELLLLKL-RELEAELEELEAELE 249

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1702 SLECNLDQEMKKNVELEREITGFKNLLKMTRKKLNEYENGEFSfhgdLKTSQFEMDIQINKLKHKIDDLTAELETAGSKC 1781
Cdd:COG1196    250 ELEAELEELEAELAELEAELEELRLELEELELELEEAQAEEYE----LLAELARLEQDIARLEERRRELEERLEELEEEL 325

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1782 LHLDTKNQILQEELLSMKTVQKKCEKLQKNKKKLEQEVINLRSHIERNMVELGQVKQYKQEIEERARQEIAEKLKEVNLF 1861
Cdd:COG1196    326 AELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEEL 405

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1862 LQAQAASQENLEQFRENnfasmKSQMELRIKDLESELSKIKTSQEDfnktELEKYKQLYLEELKVRKSLSSKLTKTNERL 1941
Cdd:COG1196    406 EEAEEALLERLERLEEE-----LEELEEALAELEEEEEEEEEALEE----AAEEEAELEEEEEALLELLAELLEEAALLE 476

                          330       340
                   ....*....|....*....|.
gi 2462517825 1942 AEVNtKLLVEKQQSRSLFTTL 1962
Cdd:COG1196    477 AALA-ELLEELAEAAARLLLL 496
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
 1073-1781 2.98e-07

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 55.89  E-value: 2.98e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1073 IEQLGMECKDSVSLLkIQDAALSCERLLELKKNHCELLTVKIKKMEDKVNVLQrelSETKEIKSQLEHQKVEWERELCSL 1152
Cdd:pfam15921  247 LEALKSESQNKIELL-LQQHQDRIEQLISEHEVEITGLTEKASSARSQANSIQ---SQLEIIQEQARNQNSMYMRQLSDL 322

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1153 RFSLNQEEEKRRNADTLYEKIREQLRRK----EEQYRKEVEVKQQLELSLQTLEMELRTVKSNLNqvvqeRNDAQRQLSR 1228
Cdd:pfam15921  323 ESTVSQLRSELREAKRMYEDKIEELEKQlvlaNSELTEARTERDQFSQESGNLDDQLQKLLADLH-----KREKELSLEK 397

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1229 EQNARM----LQDGILTNHLSKQ--------KEIEMAQKKMNSENSHSHEEE-KDLSHKNSMLqEEIAMLRLEIDTIKnq 1295
Cdd:pfam15921  398 EQNKRLwdrdTGNSITIDHLRRElddrnmevQRLEALLKAMKSECQGQMERQmAAIQGKNESL-EKVSSLTAQLESTK-- 474

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1296 nqEKEKKCFEDLKIVKEKNEDLQKTIKQneetLTQTISQYNGRLSVLTAENAMLNSKLENEKQSKERLEAE------VES 1369
Cdd:pfam15921  475 --EMLRKVVEELTAKKMTLESSERTVSD----LTASLQEKERAIEATNAEITKLRSRVDLKLQELQHLKNEgdhlrnVQT 548

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1370 YHSRLAAAIHDRDQS-ETSKRELE----LAFQRARD------ECSRLQDKMN---FDVSNLKDNNEILSQQLFKTESKLN 1435
Cdd:pfam15921  549 ECEALKLQMAEKDKViEILRQQIEnmtqLVGQHGRTagamqvEKAQLEKEINdrrLELQEFKILKDKKDAKIRELEARVS 628

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1436 SLEIEFHHTRDALREKTLGLERVQKDLSQTQCQMK----EMEQKYQNEQVKVNKYIGKQESVEERLSQLQSENMLLRQQL 1511
Cdd:pfam15921  629 DLELEKVKLVNAGSERLRAVKDIKQERDQLLNEVKtsrnELNSLSEDYEVLKRNFRNKSEEMETTTNKLKMQLKSAQSEL 708

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1512 DDAHNKADNKE-------KTVINIQDQFHAIVQKLQAESEKQSLLLEernkeliSECNHLKERQYQYENEKaerevvvrQ 1584
Cdd:pfam15921  709 EQTRNTLKSMEgsdghamKVAMGMQKQITAKRGQIDALQSKIQFLEE-------AMTNANKEKHFLKEEKN--------K 773

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1585 LQQELADTLKKQSMSEASLEVtsryrinLEDETQDLKKKLGQIRNQLQEAQDRHTEAvrcaekmQDHKQKLEKDNAKLKv 1664
Cdd:pfam15921  774 LSQELSTVATEKNKMAGELEV-------LRSQERRLKEKVANMEVALDKASLQFAEC-------QDIIQRQEQESVRLK- 838

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1665 tVKKQMDkIEELQKNLLNAN-------LSEDEKEQLKKLMELKQSLECNLDQEMKKNVELEREIT-GFKNLLKMTRKKLN 1736
Cdd:pfam15921  839 -LQHTLD-VKELQGPGYTSNssmkprlLQPASFTRTHSNVPSSQSTASFLSHHSRKTNALKEDPTrDLKQLLQELRSVIN 916

                          730       740       750       760
                   ....*....|....*....|....*....|....*....|....*
gi 2462517825 1737 EYENGEFSfhgdlKTSQFEMDIQINKLKHKIDDLTAELETAGSKC 1781
Cdd:pfam15921  917 EEPTVQLS-----KAEDKGRAPSLGALDDRVRDCIIESSLRSDIC 956
Ank_4 pfam13637
Ankyrin repeats (many copies);
113-166 3.05e-07

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 48.81  E-value: 3.05e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 2462517825  113 NRTALMKAVQCQEEKCATILLEHGADPNLADVHGNTALHYAVYNEDISVATKLL 166
Cdd:pfam13637    1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
1175-1659 3.69e-07

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 55.54  E-value: 3.69e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1175 EQLRRKEEQYRKEVEVKQQLELSLQTLEMELRTVKSNLNQVVQERNDAQRQLSREQNARMLQDgiLTNHL-SKQKEIEMA 1253
Cdd:COG4717     74 KELEEELKEAEEKEEEYAELQEELEELEEELEELEAELEELREELEKLEKLLQLLPLYQELEA--LEAELaELPERLEEL 151

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1254 QKKMnsenshshEEEKDLSHKNSMLQEEIAMLRLEIDTIKNQNQEKEKKCFEDLkivKEKNEDLQKTIKQNEETLTQTIS 1333
Cdd:COG4717    152 EERL--------EELRELEEELEELEAELAELQEELEELLEQLSLATEEELQDL---AEELEELQQRLAELEEELEEAQE 220

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1334 QYNGRLSVLTAENAMLNSKLENEKQSKERLEAEVESyhSRLAAAIHDRDQSETSKRELELAFQRA--------RDECSRL 1405
Cdd:COG4717    221 ELEELEEELEQLENELEAAALEERLKEARLLLLIAA--ALLALLGLGGSLLSLILTIAGVLFLVLgllallflLLAREKA 298

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1406 QDKMNFDVSNLKDNNEILSQQlfKTESKLNSLEIEFHHTRDALREKTLGLERVQKDLSQTQCQMKEMEQKYQNEQVKVNK 1485
Cdd:COG4717    299 SLGKEAEELQALPALEELEEE--ELEELLAALGLPPDLSPEELLELLDRIEELQELLREAEELEEELQLEELEQEIAALL 376

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1486 YIGKQESVEErlsqlqsenmlLRQQLdDAHNKADNKEKTVINIQDQFHAIVQKLQAESEKQSLlleernkelisecNHLK 1565
Cdd:COG4717    377 AEAGVEDEEE-----------LRAAL-EQAEEYQELKEELEELEEQLEELLGELEELLEALDE-------------EELE 431

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1566 ERQYQYENEKAEREVVVRQLQQELADTlkkqsmsEASLEVTSRyrinlEDETQDLKKKLGQIRNQLQEAQDRHTEAVRCA 1645
Cdd:COG4717    432 EELEELEEELEELEEELEELREELAEL-------EAELEQLEE-----DGELAELLQELEELKAELRELAEEWAALKLAL 499

                          490
                   ....*....|....
gi 2462517825 1646 EKMQDHKQKLEKDN 1659
Cdd:COG4717    500 ELLEEAREEYREER 513
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 1113-1704 4.32e-07

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 55.41  E-value: 4.32e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1113 KIKKMEDKVNVLQRELSETKEIKSQLehqkvewERELCSLRFSLNQEEEKRRNADTLYEKIREQLRRKEEQYRKEVEVKQ 1192
Cdd:TIGR04523   97 KINKLNSDLSKINSEIKNDKEQKNKL-------EVELNKLEKQKKENKKNIDKFLTEIKKKEKELEKLNNKYNDLKKQKE 169

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1193 QLELSLQTLEMELRTVKSNLNQVVQERNdaqrqlsreqnarmlqdgILTNHLSKQKEIEMAQKKMNSENSHSHEEEKDLS 1272
Cdd:TIGR04523  170 ELENELNLLEKEKLNIQKNIDKIKNKLL------------------KLELLLSNLKKKIQKNKSLESQISELKKQNNQLK 231

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1273 HKNSMLQEEIAMLRLEIDTIKNQNQEKEKKCFEDLKIVKEKNEDLQKTIKQNEEtLTQTISQYNGRLSVLTAE-----NA 1347
Cdd:TIGR04523  232 DNIEKKQQEINEKTTEISNTQTQLNQLKDEQNKIKKQLSEKQKELEQNNKKIKE-LEKQLNQLKSEISDLNNQkeqdwNK 310

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1348 MLNSKLENEKQSKERLEAEVESYHSRLAAAIHDRDQSETSKRELELAFQRARDECSRLQDKmnfdVSNLKDNNEILSQQL 1427
Cdd:TIGR04523  311 ELKSELKNQEKKLEEIQNQISQNNKIISQLNEQISQLKKELTNSESENSEKQRELEEKQNE----IEKLKKENQSYKQEI 386

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1428 FKTESKLNSLEIEFHHTRDALREKTLGLERVQKDLSQTQCQMKEMEQKYQNEQVKVNKYIGKQESVEERLSQLQSENMLL 1507
Cdd:TIGR04523  387 KNLESQINDLESKIQNQEKLNQQKDEQIKKLQQEKELLEKEIERLKETIIKNNSEIKDLTNQDSVKELIIKNLDNTRESL 466

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1508 RQQLDDAHNKADNKEKTVINIQDQFHAIVQKLQAESEKQSlLLEERNKELISECNHLKERQYQYENEKAEREVVVRQLQQ 1587
Cdd:TIGR04523  467 ETQLKVLSRSINKIKQNLEQKQKELKSKEKELKKLNEEKK-ELEEKVKDLTKKISSLKEKIEKLESEKKEKESKISDLED 545

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1588 EL---ADTLKKQsmseaslevtsryriNLEDETQDLKKKLGQIRNQLQEAQDRHTEAVRCAEKMQDHKQKLEKDNAKLKV 1664
Cdd:TIGR04523  546 ELnkdDFELKKE---------------NLEKEIDEKNKEIEELKQTQKSLKKKQEEKQELIDQKEKEKKDLIKEIEEKEK 610

                          570       580       590       600
                   ....*....|....*....|....*....|....*....|
gi 2462517825 1665 TVKKQMDKIEELQKNllNANLSEDEKEQLKKLMELKQSLE 1704
Cdd:TIGR04523  611 KISSLEKELEKAKKE--NEKLSSIIKNIKSKKNKLKQEVK 648
PTZ00121 PTZ00121
MAEBL; Provisional
 1468-1953 5.91e-07

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 55.15  E-value: 5.91e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1468 QMKEMEQKYQNEQVKVNKYIGKQESVEERLSQLQSENMLLRQQLDDAHNKADNKEKTVINIQDQFHAIVQKLQAeSEKQS 1547
Cdd:PTZ00121  1288 EKKKADEAKKAEEKKKADEAKKKAEEAKKADEAKKKAEEAKKKADAAKKKAEEAKKAAEAAKAEAEAAADEAEA-AEEKA 1366

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1548 LLLEERNKELISECNHLKERQYqyENEKAEREVVVRQLQQELADTLKKQSMSEASLEvTSRYRINLEDETQDLKKKLGQI 1627
Cdd:PTZ00121  1367 EAAEKKKEEAKKKADAAKKKAE--EKKKADEAKKKAEEDKKKADELKKAAAAKKKAD-EAKKKAEEKKKADEAKKKAEEA 1443

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1628 RnQLQEAQDRHTEAVRCAEKMQDHKQKLEKDNAKLKVTVKKQMD----KIEELQKNLLNANLSEDEK---EQLKKLMELK 1700
Cdd:PTZ00121  1444 K-KADEAKKKAEEAKKAEEAKKKAEEAKKADEAKKKAEEAKKADeakkKAEEAKKKADEAKKAAEAKkkaDEAKKAEEAK 1522

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1701 QSLECNLDQEMKKNVELER--------EITGFKNLLKM-TRKKLNEYENGEFSFHGDLKTSQFEMDIQiNKLKHKIDDLT 1771
Cdd:PTZ00121  1523 KADEAKKAEEAKKADEAKKaeekkkadELKKAEELKKAeEKKKAEEAKKAEEDKNMALRKAEEAKKAE-EARIEEVMKLY 1601

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1772 AELETAGSKCLHLDTKNQILQEELLSMKTVQKKCEKLQKNKKKLEQEVINLRSHIERNMVELGQVKQYKQE----IEERA 1847
Cdd:PTZ00121  1602 EEEKKMKAEEAKKAEEAKIKAEELKKAEEEKKKVEQLKKKEAEEKKKAEELKKAEEENKIKAAEEAKKAEEdkkkAEEAK 1681

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1848 RQEIAEKLKEVNLFLQAQAASQenLEQFRENNFASMKSQMELRikdLESELSKIKTSQEDfNKTELEKYKQlylEELKVR 1927
Cdd:PTZ00121  1682 KAEEDEKKAAEALKKEAEEAKK--AEELKKKEAEEKKKAEELK---KAEEENKIKAEEAK-KEAEEDKKKA---EEAKKD 1752

                          490       500
                   ....*....|....*....|....*.
gi 2462517825 1928 KSLSSKLTKTNERLAEVNTKLLVEKQ 1953
Cdd:PTZ00121  1753 EEEKKKIAHLKKEEEKKAEEIRKEKE 1778
Ank_5 pfam13857
Ankyrin repeats (many copies);
132-186 8.07e-07

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 47.73  E-value: 8.07e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 2462517825  132 LLEHG-ADPNLADVHGNTALHYAVYNEDISVATKLLLYDANIEAKNKDDLTPLLLA 186
Cdd:pfam13857    1 LLEHGpIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
1622-1956 8.14e-07

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 54.30  E-value: 8.14e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1622 KKLGQIRNQLQEAQDRHTEAVRCAEKMQDHKQKLEKDNAKLKVTVKKQMDKIEELQKNLLNAnlsEDEKEQLKKLMELKQ 1701
Cdd:PRK03918   165 KNLGEVIKEIKRRIERLEKFIKRTENIEELIKEKEKELEEVLREINEISSELPELREELEKL---EKEVKELEELKEEIE 241

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1702 SLECNLDQEMKKNVELEREITGFKNLLKMTRKKLNEYENGEfsfhGDLKTSQFEMD--IQINKLKHKIDDLTAELETAGS 1779
Cdd:PRK03918   242 ELEKELESLEGSKRKLEEKIRELEERIEELKKEIEELEEKV----KELKELKEKAEeyIKLSEFYEEYLDELREIEKRLS 317

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1780 KclhLDTKNQILQEELLSMKTVQKKCEKLQKNKKKLEQEVINLRSHI---ERNMVELGQVKQYKQEIEERARQEIAEKLK 1856
Cdd:PRK03918   318 R---LEEEINGIEERIKELEEKEERLEELKKKLKELEKRLEELEERHelyEEAKAKKEELERLKKRLTGLTPEKLEKELE 394

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1857 EVNlflQAQAASQENLEQFREnnfasMKSQMELRIKDLESELSKIKTSQ-----------EDFNKTELEKYKQLYLEELK 1925
Cdd:PRK03918   395 ELE---KAKEEIEEEISKITA-----RIGELKKEIKELKKAIEELKKAKgkcpvcgreltEEHRKELLEEYTAELKRIEK 466

                          330       340       350
                   ....*....|....*....|....*....|.
gi 2462517825 1926 VRKSLSSKLTKTNERLAEVNTKLLVEKQQSR 1956
Cdd:PRK03918   467 ELKEIEEKERKLRKELRELEKVLKKESELIK 497
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 1374-1637 9.52e-07

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 53.61  E-value: 9.52e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1374 LAAAIHDRDQSETSKRELELAFQRARDECSRLQDKmnfdVSNLKDNNEILSQQLFKTESKLNSLEIEFHHTRDALREKTL 1453
Cdd:COG4942     15 AAAQADAAAEAEAELEQLQQEIAELEKELAALKKE----EKALLKQLAALERRIAALARRIRALEQELAALEAELAELEK 90

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1454 GLERVQKDLSQTQCQMKEMEQKYQNeqvkvnkyIGKQESVEERLSQLQSENMLLRQQLDDAHNKADnkektviniQDQFH 1533
Cdd:COG4942     91 EIAELRAELEAQKEELAELLRALYR--------LGRQPPLALLLSPEDFLDAVRRLQYLKYLAPAR---------REQAE 153

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1534 AIVQKLQAESEKQSLLLEERnKELISECNHLKERQYQYENEKAEREVVVRQLQQELADTLKKQSmseaslevtsryriNL 1613
Cdd:COG4942    154 ELRADLAELAALRAELEAER-AELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELA--------------EL 218

                          250       260
                   ....*....|....*....|....
gi 2462517825 1614 EDETQDLKKKLGQIRNQLQEAQDR 1637
Cdd:COG4942    219 QQEAEELEALIARLEAEAAAAAER 242
PHA03095 PHA03095
ankyrin-like protein; Provisional
 66-210 1.10e-06

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 53.49  E-value: 1.10e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825   66 LLLRK-NGLNDRDKMNRTALHLACANGHP--EVVTLLVDRKCQLNVCDNENRTAL-MKAVQCQeekCATI----LLEHGA 137
Cdd:PHA03095   172 LLIDAgADVYAVDDRFRSLLHHHLQSFKPraRIVRELIRAGCDPAATDMLGNTPLhSMATGSS---CKRSlvlpLLIAGI 248

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2462517825  138 DPNLADVHGNTALHYA-VYNEDISVAtKLLLYDANIEAKNKDDLTPLLLAVSGKKQQMVEFLIKKKANVNAVDK 210
Cdd:PHA03095   249 SINARNRYGQTPLHYAaVFNNPRACR-RLIALGADINAVSSDGNTPLSLMVRNNNGRAVRAALAKNPSAETVAA 321
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 121-292 1.28e-06

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 53.53  E-value: 1.28e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825  121 VQCQEEKCATILLEHGADPNLADVHGNTALHYAVYNEDISVATKLLLYDANIEAKNKDDLTPLLLAVSGKKQQMVEFLIK 200
Cdd:PHA02876   153 IQQDELLIAEMLLEGGADVNAKDIYCITPIHYAAERGNAKMVNLLLSYGADVNIIALDDLSVLECAVDSKNIDTIKAIID 232

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825  201 KKANVNAVDkLESSHQLISEYKEERIPKHSSQNS-NSVDESSEDSLSRLSGKPGVDDSWPTSDDEDLNFDTKNVPKPSLA 279
Cdd:PHA02876   233 NRSNINKND-LSLLKAIRNEDLETSLLLYDAGFSvNSIDDCKNTPLHHASQAPSLSRLVPKLLERGADVNAKNIKGETPL 311

                          170
                   ....*....|...
gi 2462517825  280 KLMTASQQSRKNL 292
Cdd:PHA02876   312 YLMAKNGYDTENI 324
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 1146-1377 1.33e-06

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 52.84  E-value: 1.33e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1146 ERELCSLRFSLNQEEEKRRNADTLYEKIREQLRRKEEQYrkevevkQQLELSLQTLEMELRTVKSNLNQVVQERNDAQRQ 1225
Cdd:COG4942     26 EAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRI-------AALARRIRALEQELAALEAELAELEKEIAELRAE 98

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1226 LSREQN--ARMLQDgiltnhLSKQKEIEMAQKKMNSENSHSHEEEKD-LSHKNSMLQEEIAMLRLEIDTIKNQNQEKEKK 1302
Cdd:COG4942     99 LEAQKEelAELLRA------LYRLGRQPPLALLLSPEDFLDAVRRLQyLKYLAPARREQAEELRADLAELAALRAELEAE 172

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2462517825 1303 cFEDLKIVKEKNEDLQKTIKQNEETLTQTISQYNGRLSVLTAENAMLNSKLENEKQSKERLEAEVESYHSRLAAA 1377
Cdd:COG4942    173 -RAELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAEAAAAAERTPAA 246
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
 1491-1962 1.46e-06

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 53.64  E-value: 1.46e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1491 ESVEERLSQLQSENMLLRQQLDDAHNKADNKEktviniqdqfhAIVQKLQAES----------EKQSLLLEERNKELISE 1560
Cdd:pfam01576   85 EEEEERSQQLQNEKKKMQQHIQDLEEQLDEEE-----------AARQKLQLEKvtteakikklEEDILLLEDQNSKLSKE 153

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1561 CNHLKERQYQYENEKAEREVVVRQLQQ----------ELADTLKKQSMSEASLEVTSRyriNLEDETQDLKKKLGQIRNQ 1630
Cdd:pfam01576  154 RKLLEERISEFTSNLAEEEEKAKSLSKlknkheamisDLEERLKKEEKGRQELEKAKR---KLEGESTDLQEQIAELQAQ 230

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1631 LQEAQdrhTEAVRCAEKMQDHKQKLEKDNAKLKVTVKKQ---MDKIEELQKNLLNANLSEDEKEQLKK-----LMELKQS 1702
Cdd:pfam01576  231 IAELR---AQLAKKEEELQAALARLEEETAQKNNALKKIrelEAQISELQEDLESERAARNKAEKQRRdlgeeLEALKTE 307

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1703 LECNLD-----QEMKKNVELEreitgfknlLKMTRKKLNEyengefsfhgdlKTSQFEMDIQINKLKH--KIDDLTAELE 1775
Cdd:pfam01576  308 LEDTLDttaaqQELRSKREQE---------VTELKKALEE------------ETRSHEAQLQEMRQKHtqALEELTEQLE 366

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1776 TAGSKCLHLDTKNQILQEELLS----MKTVQKKCEKLQKNKKKLEQEVINLRSHI---ERNMVELG-------------- 1834
Cdd:pfam01576  367 QAKRNKANLEKAKQALESENAElqaeLRTLQQAKQDSEHKRKKLEGQLQELQARLsesERQRAELAeklsklqselesvs 446

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1835 ------------------QVKQYKQEIEERARQEIAEKLKEVNLFLQAQAASQENLEQFRENNFAsmKSQMELRIKDLES 1896
Cdd:pfam01576  447 sllneaegkniklskdvsSLESQLQDTQELLQEETRQKLNLSTRLRQLEDERNSLQEQLEEEEEA--KRNVERQLSTLQA 524

                          490       500       510       520       530       540       550
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2462517825 1897 ELSKIKTSQEDFNKT-----ELEKYKQLYLEELKVR----KSLSSKLTKTNERLAEVNTKLLVEKQQSRSLFTTL 1962
Cdd:pfam01576  525 QLSDMKKKLEEDAGTlealeEGKKRLQRELEALTQQleekAAAYDKLEKTKNRLQQELDDLLVDLDHQRQLVSNL 599
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 1104-1330 1.95e-06

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 53.14  E-value: 1.95e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1104 KNHCELLTVKIKKMEDKVNVLQRELSETKEIKSQLEHQKVEWERELCSLRFSLNQEEEKRRNADTLYEKIREQLRRKEEQ 1183
Cdd:TIGR02168  795 KEELKALREALDELRAELTLLNEEAANLRERLESLERRIAATERRLEDLEEQIEELSEDIESLAAEIEELEELIEELESE 874

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1184 YRKEVEVKQQLELSLQTLEMELRTVKSNLNQVVQERNDAQRQLS--REQNARM-LQDGILTNHLSKQKEIEMAQKKMNSE 1260
Cdd:TIGR02168  875 LEALLNERASLEEALALLRSELEELSEELRELESKRSELRRELEelREKLAQLeLRLEGLEVRIDNLQERLSEEYSLTLE 954

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462517825 1261 NSHSHEEEKDLSHKNsmLQEEIAMLRLEIDTIKNQNQ------EKEKKCFEDLKivKEKnEDLQKTIKQNEETLTQ 1330
Cdd:TIGR02168  955 EAEALENKIEDDEEE--ARRRLKRLENKIKELGPVNLaaieeyEELKERYDFLT--AQK-EDLTEAKETLEEAIEE 1025
Ank_5 pfam13857
Ankyrin repeats (many copies);
68-117 1.97e-06

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 46.57  E-value: 1.97e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 2462517825   68 LRKNG---LNDRDKMNRTALHLACANGHPEVVTLLVDRKCQLNVCDNENRTAL 117
Cdd:pfam13857    1 LLEHGpidLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTAL 53
Ank_4 pfam13637
Ankyrin repeats (many copies);
50-100 3.18e-06

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 46.11  E-value: 3.18e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 2462517825   50 IHKAASAGNVAKVQqilLLRKNG--LNDRDKMNRTALHLACANGHPEVVTLLV 100
Cdd:pfam13637    5 LHAAAASGHLELLR---LLLEKGadINAVDGNGETALHFAASNGNVEVLKLLL 54
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 56-237 4.48e-06

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 51.50  E-value: 4.48e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825   56 AGNVAKVQQILLLRKNGLNDRDKMNRTALHLACANGHPEVVTLLVDRKCQLNVCDNENRTALMKAVQ------------- 122
Cdd:PHA02874    11 SGDIEAIEKIIKNKGNCINISVDETTTPLIDAIRSGDAKIVELFIKHGADINHINTKIPHPLLTAIKigahdiikllidn 90

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825  123 ----------CQEEKCATILLEHGADPNLADVHGNTALHYAVYNEDISVATKLLLYDANIEAKNKDDLTPLLLAVSGKKQ 192
Cdd:PHA02874    91 gvdtsilpipCIEKDMIKTILDCGIDVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFF 170

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*.
gi 2462517825  193 QMVEFLIKKKANVNAVD-KLESSHQLISEYKEERIPKHSSQNSNSV 237
Cdd:PHA02874   171 DIIKLLLEKGAYANVKDnNGESPLHNAAEYGDYACIKLLIDHGNHI 216
PTZ00121 PTZ00121
MAEBL; Provisional
 1098-1793 5.08e-06

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 52.07  E-value: 5.08e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1098 RLLELKKNHCELLTVKIKKMEDkVNVLQRELSETKEIKSQLEHQKVEWERELCSLRFSLNQEEEKRRNADTLYekiREQL 1177
Cdd:PTZ00121  1213 KAEEARKAEDAKKAEAVKKAEE-AKKDAEEAKKAEEERNNEEIRKFEEARMAHFARRQAAIKAEEARKADELK---KAEE 1288

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1178 RRKEEQYRKEVEVKQQLELSLQTleMELRTVKSNLNQVVQERNDAQRQLSREQNARMLQDGILTNHLSKQKEIEMAQKKM 1257
Cdd:PTZ00121  1289 KKKADEAKKAEEKKKADEAKKKA--EEAKKADEAKKKAEEAKKKADAAKKKAEEAKKAAEAAKAEAEAAADEAEAAEEKA 1366

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1258 NSENSHSHEEEKDLSHKNSMLQEeiamlRLEIDTIKNQNQEKEKKCfEDLKIVKEKNEDLQKTIKQNEEtltqtisqyng 1337
Cdd:PTZ00121  1367 EAAEKKKEEAKKKADAAKKKAEE-----KKKADEAKKKAEEDKKKA-DELKKAAAAKKKADEAKKKAEE----------- 1429

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1338 rlsVLTAENAmlNSKLENEKQSKE-RLEAEVESYHSRLAAAIHDRDQSETSKRELELAfqRARDECSRLQDKMNFDVSNL 1416
Cdd:PTZ00121  1430 ---KKKADEA--KKKAEEAKKADEaKKKAEEAKKAEEAKKKAEEAKKADEAKKKAEEA--KKADEAKKKAEEAKKKADEA 1502

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1417 KDnneilsqqlfKTESKLNSLEIEFHHTRDALREKTLGLERVQKDlsqtqcQMKEMEQKYQNEQVKVNKYIGKQES---V 1493
Cdd:PTZ00121  1503 KK----------AAEAKKKADEAKKAEEAKKADEAKKAEEAKKAD------EAKKAEEKKKADELKKAEELKKAEEkkkA 1566

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1494 EERLSQLQSENMLLRQQlddahNKADNKEKTVINIQDQFHAIVQKLQAESEKQSllLEERNK-ELISECNHLKERQYQYE 1572
Cdd:PTZ00121  1567 EEAKKAEEDKNMALRKA-----EEAKKAEEARIEEVMKLYEEEKKMKAEEAKKA--EEAKIKaEELKKAEEEKKKVEQLK 1639

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1573 NEKAEREVVVRQLQQELADTLKKQSMSEASLEVTSRYRINLEDETQDLKKKLGQIRNQLQEAqdRHTEAVRCAEKMQDHK 1652
Cdd:PTZ00121  1640 KKEAEEKKKAEELKKAEEENKIKAAEEAKKAEEDKKKAEEAKKAEEDEKKAAEALKKEAEEA--KKAEELKKKEAEEKKK 1717

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1653 -QKLEKDNAKLKVTVKKQMDKIEELQKNLLNANLSEDEKEQLKKLMELKQSLECNLDQEMKKNVELEREITGFKNLLKMT 1731
Cdd:PTZ00121  1718 aEELKKAEEENKIKAEEAKKEAEEDKKKAEEAKKDEEEKKKIAHLKKEEEKKAEEIRKEKEAVIEEELDEEDEKRRMEVD 1797

                          650       660       670       680       690       700
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462517825 1732 RKKLNEYENGEFSFHGDLKTSQFemdiqINKLKHKIDDLTAELetagskclhLDTKNQILQE 1793
Cdd:PTZ00121  1798 KKIKDIFDNFANIIEGGKEGNLV-----INDSKEMEDSAIKEV---------ADSKNMQLEE 1845
MAD pfam05557
Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint ...
 1383-1928 5.96e-06

Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint (Mitotic arrest deficient or MAD) proteins. The mitotic spindle checkpoint monitors proper attachment of the bipolar spindle to the kinetochores of aligned sister chromatids and causes a cell cycle arrest in prometaphase when failures occur. Multiple components of the mitotic spindle checkpoint have been identified in yeast and higher eukaryotes. In S.cerevisiae, the existence of a Mad1-dependent complex containing Mad2, Mad3, Bub3 and Cdc20 has been demonstrated.


Pssm-ID: 461677 [Multi-domain]  Cd Length: 660  Bit Score: 51.28  E-value: 5.96e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1383 QSETSKRELELAFQRARDECSRLQDKMNFDVSNLKDNNEILSQQLFKTESKLNSLEIEFHHTRDALREKTLGLERVQKDL 1462
Cdd:pfam05557   13 QLQNEKKQMELEHKRARIELEKKASALKRQLDRESDRNQELQKRIRLLEKREAEAEEALREQAELNRLKKKYLEALNKKL 92

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1463 SQTQCQMKEMEQKYQNEQVKVNKYIGKQESVEERLSQLQSENMLLRQQLDDAHNKADNKEKTVINIQDQfhaivQKLQAE 1542
Cdd:pfam05557   93 NEKESQLADAREVISCLKNELSELRRQIQRAELELQSTNSELEELQERLDLLKAKASEAEQLRQNLEKQ-----QSSLAE 167

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1543 SEKQSLLLEERNKelisecnhlkerqyQYENEKAerevVVRQLQQELADTLKKQSMSEASLEVTSRYRIN------LEDE 1616
Cdd:pfam05557  168 AEQRIKELEFEIQ--------------SQEQDSE----IVKNSKSELARIPELEKELERLREHNKHLNENienkllLKEE 229

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1617 TQDLKKKLGQIRNQLQEAQDRHTEAVRCAEKMQDHKqKLEKDNAKLKVTVKKQMDKIEELQ---------KNLLNANLSE 1687
Cdd:pfam05557  230 VEDLKRKLEREEKYREEAATLELEKEKLEQELQSWV-KLAQDTGLNLRSPEDLSRRIEQLQqreivlkeeNSSLTSSARQ 308

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1688 DEKEQLKKLMELKQSLECNLDQEM-------------KKNVELEREITGFKNLLKMTRKKLNEYENGEfsfhgDLKTSQF 1754
Cdd:pfam05557  309 LEKARRELEQELAQYLKKIEDLNKklkrhkalvrrlqRRVLLLTKERDGYRAILESYDKELTMSNYSP-----QLLERIE 383

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1755 EMDIQINKLKHKIDDLTAELETAGSKCLHLDTKNQILQEELLSMKTvqkkcEKLQKNKKKLEQEVINLRSHIERNMVELG 1834
Cdd:pfam05557  384 EAEDMTQKMQAHNEEMEAQLSVAEEELGGYKQQAQTLERELQALRQ-----QESLADPSYSKEEVDSLRRKLETLELERQ 458

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1835 QVKQYKQEIE-ERARQEIAEKLKEV---------NLFLQAQAASQENLEQFRENNfASMKSQMELRIKDLESELSKIKTS 1904
Cdd:pfam05557  459 RLREQKNELEmELERRCLQGDYDPKktkvlhlsmNPAAEAYQQRKNQLEKLQAEI-ERLKRLLKKLEDDLEQVLRLPETT 537

                          570       580
                   ....*....|....*....|....
gi 2462517825 1905 QEDFNKTELEKYKQLYLEELKVRK 1928
Cdd:pfam05557  538 STMNFKEVLDLRKELESAELKNQR 561
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 1755-1928 6.50e-06

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 49.54  E-value: 6.50e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1755 EMDIQINKLKHKIDDLTAELEtagskclHLDTKNQILQEELlsmKTVQKKCEKLQKNKKKLEQEVINLRSHIERNMVELG 1834
Cdd:COG1579     14 ELDSELDRLEHRLKELPAELA-------ELEDELAALEARL---EAAKTELEDLEKEIKRLELEIEEVEARIKKYEEQLG 83

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1835 QVKQYKQ------EIE--ERARQEIAEKLKEVNLFLQAQAASQENLEQF---RENNFASMKSQMELRIKDLESELSKIKT 1903
Cdd:COG1579     84 NVRNNKEyealqkEIEslKRRISDLEDEILELMERIEELEEELAELEAElaeLEAELEEKKAELDEELAELEAELEELEA 163

                          170       180
                   ....*....|....*....|....*
gi 2462517825 1904 SQEDFNKTELEKYKQLYlEELKVRK 1928
Cdd:COG1579    164 EREELAAKIPPELLALY-ERIRKRK 187
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 82-202 8.01e-06

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 51.17  E-value: 8.01e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825   82 TALHLACANGHPEVVTLLVDRKCQLN------VCDNENRTALMK--------AVQCQEEKCATILLEHGADPNLADVHGN 147
Cdd:cd22192     91 TALHIAVVNQNLNLVRELIARGADVVspratgTFFRPGPKNLIYygehplsfAACVGNEEIVRLLIEHGADIRAQDSLGN 170

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2462517825  148 TALHYAVYNEDISVATK----LLLYDANIEA------KNKDDLTPLLLAVSGKKQQMVEFLIKKK 202
Cdd:cd22192    171 TVLHILVLQPNKTFACQmydlILSYDKEDDLqpldlvPNNQGLTPFKLAAKEGNIVMFQHLVQKR 235
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 1672-1956 8.09e-06

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 51.21  E-value: 8.09e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1672 KIEELQKNL--LNANLSEDEK---------EQLKKLMELKQSLEcnldqemkknvELEREITGfkNLLKMTRKKLNEyen 1740
Cdd:TIGR02168  180 KLERTRENLdrLEDILNELERqlkslerqaEKAERYKELKAELR-----------ELELALLV--LRLEELREELEE--- 243

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1741 gefsfhgdLKTSQFEMDIQINKLKHKIDDLTAELETAGSKCLHLDTKNQILQEELLSMKTVQKKCEK-----------LQ 1809
Cdd:TIGR02168  244 --------LQEELKEAEEELEELTAELQELEEKLEELRLEVSELEEEIEELQKELYALANEISRLEQqkqilrerlanLE 315

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1810 KNKKKLEQEVINLRSHIERNMVELGQVKQYKQEIE---ERARQEIAEKLKEVNLFLQAQAASQENLEQFReNNFASMKSQ 1886
Cdd:TIGR02168  316 RQLEELEAQLEELESKLDELAEELAELEEKLEELKeelESLEAELEELEAELEELESRLEELEEQLETLR-SKVAQLELQ 394

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2462517825 1887 MEL---RIKDLESELSKIKTSQEDFNKTELEKYKQLYLEELK-VRKSLSSK---LTKTNERLAEVNTKLLVEKQQSR 1956
Cdd:TIGR02168  395 IASlnnEIERLEARLERLEDRRERLQQEIEELLKKLEEAELKeLQAELEELeeeLEELQEELERLEEALEELREELE 471
trp TIGR00870
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ...
 82-202 1.23e-05

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273311 [Multi-domain]  Cd Length: 743  Bit Score: 50.46  E-value: 1.23e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825   82 TALHLACANGHPEVVTLLVDRKCQLNV---CD-------------NENRTALMKAVQcqEEKCATILLEHGADPNLADVH 145
Cdd:TIGR00870  130 TALHLAAHRQNYEIVKLLLERGASVPAracGDffvksqgvdsfyhGESPLNAAACLG--SPSIVALLSEDPADILTADSL 207

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462517825  146 GNTALHYAVYNEDISVATK---------LLLYDANI-------EAKNKDDLTPLLLAVSGKKQQMVEFLIKKK 202
Cdd:TIGR00870  208 GNTLLHLLVMENEFKAEYEelscqmynfALSLLDKLrdskeleVILNHQGLTPLKLAAKEGRIVLFRLKLAIK 280
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
1037-1641 1.41e-05

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 50.30  E-value: 1.41e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1037 NQIQSMDDVDDLTqssetasedcELphssYKNFML-------LIEQLgmecKDSVSLLK-----IQDAALSCERLLELKK 1104
Cdd:COG4913    198 HKTQSFKPIGDLD----------DF----VREYMLeepdtfeAADAL----VEHFDDLEraheaLEDAREQIELLEPIRE 259

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1105 NHcelltVKIKKMEDKVNVLQRELSETKEIKSQLEHQkvEWERELCSLRFSLNQEEEKRRNADTLYEKIREQLRRKEEQY 1184
Cdd:COG4913    260 LA-----ERYAAARERLAELEYLRAALRLWFAQRRLE--LLEAELEELRAELARLEAELERLEARLDALREELDELEAQI 332

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1185 RK-EVEVKQQLELSLQTLEMELRTVKSNLNQVVQERNDAqrQLSREQNARMLQDgiltnhlsKQKEIEMAQKKMNSENSH 1263
Cdd:COG4913    333 RGnGGDRLEQLEREIERLERELEERERRRARLEALLAAL--GLPLPASAEEFAA--------LRAEAAALLEALEEELEA 402

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1264 SHEEEKDLSHKNSMLQEEIAMLRLEIDTIKN------QNQEK-----EKKC---FEDLKI------VKEKNEDLQKTI-- 1321
Cdd:COG4913    403 LEEALAEAEAALRDLRRELRELEAEIASLERrksnipARLLAlrdalAEALgldEAELPFvgelieVRPEEERWRGAIer 482

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1322 ------------KQNEETLTQTISQYNGRLSVLTaenamlnSKLENEKQSKERLEAEVESYHSRLAAAIHD-RD--QSET 1386
Cdd:COG4913    483 vlggfaltllvpPEHYAAALRWVNRLHLRGRLVY-------ERVRTGLPDPERPRLDPDSLAGKLDFKPHPfRAwlEAEL 555

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1387 SKR------ELELAFQRAR----DECsrlQDKMNFDVSNLKDNNEILSQQL--FKTESKLNSLEIEfhhtRDALREKtlg 1454
Cdd:COG4913    556 GRRfdyvcvDSPEELRRHPraitRAG---QVKGNGTRHEKDDRRRIRSRYVlgFDNRAKLAALEAE----LAELEEE--- 625

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1455 LERVQKDLSQTQCQMKEMEQK---------YQNEQVKVnkyigkqESVEERLSQLQSEnmllRQQLDDAHNKadnkektV 1525
Cdd:COG4913    626 LAEAEERLEALEAELDALQERrealqrlaeYSWDEIDV-------ASAEREIAELEAE----LERLDASSDD-------L 687

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1526 INIQDQFHAIVQKLQaESEKQSLLLEERNKELISECNHLKERQYQYENEKAEREVVVRQLQQELADTLKKQSMSEaslEV 1605
Cdd:COG4913    688 AALEEQLEELEAELE-ELEEELDELKGEIGRLEKELEQAEEELDELQDRLEAAEDLARLELRALLEERFAAALGD---AV 763

                          650       660       670
                   ....*....|....*....|....*....|....*.
gi 2462517825 1606 TSRYRINLEDETQDLKKKLGQIRNQLQEAQDRHTEA 1641
Cdd:COG4913    764 ERELRENLEERIDALRARLNRAEEELERAMRAFNRE 799
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
1403-1877 1.42e-05

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 50.15  E-value: 1.42e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1403 SRLQDKMNFDVSNLKDNNEILSQQLFKTESKLNSLEI---EFHHTRDALREKTLGLERVQKDLSQTQCQMKEMEQKYQNE 1479
Cdd:COG4717     49 ERLEKEADELFKPQGRKPELNLKELKELEEELKEAEEkeeEYAELQEELEELEEELEELEAELEELREELEKLEKLLQLL 128

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1480 QvkvnkYIGKQESVEERLSQLQSENMLLRQQLD---DAHNKADNKEKTVINIQDQFHAIVQKLQAESEKQSLLLEERNKE 1556
Cdd:COG4717    129 P-----LYQELEALEAELAELPERLEELEERLEelrELEEELEELEAELAELQEELEELLEQLSLATEEELQDLAEELEE 203

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1557 LISECNHLKERQYQYENEKAEREVVVRQLQQELADTLKKQSMSEA-----------SLEVTSRYRINLEDE--------- 1616
Cdd:COG4717    204 LQQRLAELEEELEEAQEELEELEEELEQLENELEAAALEERLKEArlllliaaallALLGLGGSLLSLILTiagvlflvl 283

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1617 ------TQDLKKKLGQIRNQLQEAQDRHTEAVRCAEKMQDHKQKLEKDNAKLKVTVKKQMDKIEELQKNLLNAnlsEDEK 1690
Cdd:COG4717    284 gllallFLLLAREKASLGKEAEELQALPALEELEEEELEELLAALGLPPDLSPEELLELLDRIEELQELLREA---EELE 360

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1691 EQLKkLMELKQSLECNLDQemkKNVELEREItgfknllkmtRKKLNEYEngefsfhgdlktsqfemdiQINKLKHKIDDL 1770
Cdd:COG4717    361 EELQ-LEELEQEIAALLAE---AGVEDEEEL----------RAALEQAE-------------------EYQELKEELEEL 407

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1771 TAELEtagskclhldtknQILQEELLSMKTVQKkcEKLQKNKKKLEQEVINLRSHIERNMVELGQVKQYKQEIEE----- 1845
Cdd:COG4717    408 EEQLE-------------ELLGELEELLEALDE--EELEEELEELEEELEELEEELEELREELAELEAELEQLEEdgela 472

                          490       500       510
                   ....*....|....*....|....*....|....*
gi 2462517825 1846 RARQEIAEKLKEVNLFLQ---AQAASQENLEQFRE 1877
Cdd:COG4717    473 ELLQELEELKAELRELAEewaALKLALELLEEARE 507
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 41-209 1.42e-05

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 49.96  E-value: 1.42e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825   41 HVRDRDLGK-IHKAASAGNVAKVQQILLLRKNgLNDRDKMNRTALHLACANGHPEVVTLLVDRKCQLNVCDNENRTALMK 119
Cdd:PHA02874   118 NIKDAELKTfLHYAIKKGDLESIKMLFEYGAD-VNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVKDNNGESPLHN 196

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825  120 AVQCQEEKCATILLEHGADPNLADVHGNTALHYAV-YNEDisvATKLLLYDANIEAKNKDDLTPLLLAVSGK-KQQMVEF 197
Cdd:PHA02874   197 AAEYGDYACIKLLIDHGNHIMNKCKNGFTPLHNAIiHNRS---AIELLINNASINDQDIDGSTPLHHAINPPcDIDIIDI 273

                          170
                   ....*....|..
gi 2462517825  198 LIKKKANVNAVD 209
Cdd:PHA02874   274 LLYHKADISIKD 285
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
1474-1737 1.65e-05

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 50.02  E-value: 1.65e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1474 QKYQNEQVKVnkyigKQESVEERLSQLQSENMLLRQQLDDAHNKadnkektviniqdqfhaiVQKLQAESekQSLLLEER 1553
Cdd:COG3206    159 EAYLEQNLEL-----RREEARKALEFLEEQLPELRKELEEAEAA------------------LEEFRQKN--GLVDLSEE 213

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1554 NKELISECNHLKERQYQYENEKAEREVVVRQLQQELADTLKKQSMSEASLEVtsryrinledetQDLKKKLGQIRNQLQE 1633
Cdd:COG3206    214 AKLLLQQLSELESQLAEARAELAEAEARLAALRAQLGSGPDALPELLQSPVI------------QQLRAQLAELEAELAE 281

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1634 AQ----DRHTEAVRCAEKMQDHKQKLEKDNAKLKVTVKKQMDKIEElQKNLLNANLsEDEKEQLKKLMELKQSLEcnldq 1709
Cdd:COG3206    282 LSarytPNHPDVIALRAQIAALRAQLQQEAQRILASLEAELEALQA-REASLQAQL-AQLEARLAELPELEAELR----- 354

                          250       260
                   ....*....|....*....|....*...
gi 2462517825 1710 emkknvELEREITGFKNLLKMTRKKLNE 1737
Cdd:COG3206    355 ------RLEREVEVARELYESLLQRLEE 376
Ank_4 pfam13637
Ankyrin repeats (many copies);
146-199 2.05e-05

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 43.80  E-value: 2.05e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 2462517825  146 GNTALHYAVYNEDISVATKLLLYDANIEAKNKDDLTPLLLAVSGKKQQMVEFLI 199
Cdd:pfam13637    1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 51-179 2.18e-05

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 49.51  E-value: 2.18e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825   51 HKAASAGNVAKvqQILLLRKNGLNDRDKMNRTALHLACANGHPEVVTLlvdrkcqlnvcdnenrtalmkavqcqeekcat 130
Cdd:PTZ00322    88 QLAASGDAVGA--RILLTGGADPNCRDYDGRTPLHIACANGHVQVVRV-------------------------------- 133

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 2462517825  131 iLLEHGADPNLADVHGNTALHYAVYNEDISVATKLLLY---DANIEAKNKDD 179
Cdd:PTZ00322   134 -LLEFGADPTLLDKDGKTPLELAEENGFREVVQLLSRHsqcHFELGANAKPD 184
SCP-1 pfam05483
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ...
 1088-1632 2.61e-05

Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.


Pssm-ID: 114219 [Multi-domain]  Cd Length: 787  Bit Score: 49.33  E-value: 2.61e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1088 KIQDAALSCERLLELKKNHCELLTVKIKKMEDKVNVLQRELSETKEIKSQLEhQKVEWERElcslrfSLNQEEEKRRNAD 1167
Cdd:pfam05483  223 KIQHLEEEYKKEINDKEKQVSLLLIQITEKENKMKDLTFLLEESRDKANQLE-EKTKLQDE------NLKELIEKKDHLT 295

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1168 TLYEKIREQLRRKEEqyrkevevkqqlelSLQTLEMELRTVKSNLNQVVQERNDAQRQLSREQNAR-MLQDGILTNHLSK 1246
Cdd:pfam05483  296 KELEDIKMSLQRSMS--------------TQKALEEDLQIATKTICQLTEEKEAQMEELNKAKAAHsFVVTEFEATTCSL 361

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1247 QKEIEMAQKKMNSENSHSHEEEKDLSHKNSMLQEEIAML---RLEIDTIKNQNQEKEKKCFEdlkivKEKNEDLQKTIKQ 1323
Cdd:pfam05483  362 EELLRTEQQRLEKNEDQLKIITMELQKKSSELEEMTKFKnnkEVELEELKKILAEDEKLLDE-----KKQFEKIAEELKG 436

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1324 NEETLTQTISQYNGRLSVLTAENAMLNSKLENEKQSKERLEAEVESYHSRLAAAIHDRDQSETSKRELelaFQRARDECS 1403
Cdd:pfam05483  437 KEQELIFLLQAREKEIHDLEIQLTAIKTSEEHYLKEVEDLKTELEKEKLKNIELTAHCDKLLLENKEL---TQEASDMTL 513

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1404 RLQDKMNfDVSNLKDNNEILSQQLFKTESKLNSLEIEFHHTRDALREK----TLGLERVQKDLSQTQCQMKEMEQKYQNE 1479
Cdd:pfam05483  514 ELKKHQE-DIINCKKQEERMLKQIENLEEKEMNLRDELESVREEFIQKgdevKCKLDKSEENARSIEYEVLKKEKQMKIL 592

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1480 QVKVNKYIGKQESVEERLSQLQSENMLLR-------QQLDDAHNKADNKEKTVINIQDQFHAIVQKLQAE------SEKQ 1546
Cdd:pfam05483  593 ENKCNNLKKQIENKNKNIEELHQENKALKkkgsaenKQLNAYEIKVNKLELELASAKQKFEEIIDNYQKEiedkkiSEEK 672

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1547 SLLLEERNKELISECNHLKERQYQYENEKAEREVVVRQLQQELADTLKKQSMSEASL-----EVTSRYRINLEDETQDLK 1621
Cdd:pfam05483  673 LLEEVEKAKAIADEAVKLQKEIDKRCQHKIAEMVALMEKHKHQYDKIIEERDSELGLyknkeQEQSSAKAALEIELSNIK 752

                          570
                   ....*....|.
gi 2462517825 1622 KKLGQIRNQLQ 1632
Cdd:pfam05483  753 AELLSLKKQLE 763
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 1583-1795 3.92e-05

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 48.22  E-value: 3.92e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1583 RQLQQELADTLKKQSMSEASLEVTSRYRINLEDETQDLKKKLGQIRNQLQEAQDRHTEAVRCAEKMQDHKQKLEKDNAKL 1662
Cdd:COG4942     23 AEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAELEAQ 102

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1663 KVTVKKQMDKIEEL-QKNLLNANLSEDEKEQLKKLMELKQSLECNLDQEMKKNVELEREITGFKNLLKMTRKKLNEYENG 1741
Cdd:COG4942    103 KEELAELLRALYRLgRQPPLALLLSPEDFLDAVRRLQYLKYLAPARREQAEELRADLAELAALRAELEAERAELEALLAE 182

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....
gi 2462517825 1742 EFSFHGDLKTSQFEMDIQINKLKHKIDDLTAELETAGSKCLHLDTKNQILQEEL 1795
Cdd:COG4942    183 LEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAEA 236
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 1088-1369 3.99e-05

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 48.90  E-value: 3.99e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1088 KIQDAALSCERLLELKKNHCELLTVKIKKMEDKVNVLQRELSETKEIKSQLEHQKVEWERELCSLRFSLNQEEEKRRNAD 1167
Cdd:TIGR02168  716 QLRKELEELSRQISALRKDLARLEAEVEQLEERIAQLSKELTELEAEIEELEERLEEAEEELAEAEAEIEELEAQIEQLK 795

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1168 TLYEKIREQLRRKEEQYRKEVEVKQQLELSLQTLEMELRTVKSNLNQVVQERNDAQRQLSR--------EQNARMLQDGI 1239
Cdd:TIGR02168  796 EELKALREALDELRAELTLLNEEAANLRERLESLERRIAATERRLEDLEEQIEELSEDIESlaaeieelEELIEELESEL 875

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1240 ltNHLSKQK------------EIEMAQKKMNSENSHSHEEEKDLSHKNSML---QEEIAMLRLEIDTIKNQNQEKEKKCF 1304
Cdd:TIGR02168  876 --EALLNERasleealallrsELEELSEELRELESKRSELRRELEELREKLaqlELRLEGLEVRIDNLQERLSEEYSLTL 953

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2462517825 1305 EDLKIVKEKNEDLQKTIKQNEETLTQTI--------------SQYNGRLSVLTAENAMLNSKLENEKQSKERLEAEVES 1369
Cdd:TIGR02168  954 EEAEALENKIEDDEEEARRRLKRLENKIkelgpvnlaaieeyEELKERYDFLTAQKEDLTEAKETLEEAIEEIDREARE 1032
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 1115-1539 4.44e-05

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 48.91  E-value: 4.44e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1115 KKMEDKVNVLQRELSETKEIKSQLEHQKVEWERELCSLRFSLNQEEEKRRNAdtlyEKIREQLRRKEEQYRKEVEvkqQL 1194
Cdd:TIGR02169  670 RSEPAELQRLRERLEGLKRELSSLQSELRRIENRLDELSQELSDASRKIGEI----EKEIEQLEQEEEKLKERLE---EL 742

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1195 ELSLQTLEmelrtvksnlnqvvQERNDAQRQLsrEQNARMLQDgiltnhlsKQKEIEMAQKKMNS-ENSHSHEEEKDLSH 1273
Cdd:TIGR02169  743 EEDLSSLE--------------QEIENVKSEL--KELEARIEE--------LEEDLHKLEEALNDlEARLSHSRIPEIQA 798

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1274 KNSMLQEEIAMLRLEIDTIknqNQEKEKKCFEdlkivKEKNEDLQKTIKQNEETLTQTISQyngrlsvLTAENAMLNSKL 1353
Cdd:TIGR02169  799 ELSKLEEEVSRIEARLREI---EQKLNRLTLE-----KEYLEKEIQELQEQRIDLKEQIKS-------IEKEIENLNGKK 863

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1354 ENEKQSKERLEAEVESYHSRLAAAIHDRDQSETSKRELelafQRARDECSRLQDKMNFDVSNLKDNNEILSQQLFKTESK 1433
Cdd:TIGR02169  864 EELEEELEELEAALRDLESRLGDLKKERDELEAQLREL----ERKIEELEAQIEKKRKRLSELKAKLEALEEELSEIEDP 939

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1434 LNSLEIEfhhtrdalREKTLGLERVQKDLSQTQCQMKEMEQkyqneqvkVN-KYIGKQESVEERLSQLQSENMLL---RQ 1509
Cdd:TIGR02169  940 KGEDEEI--------PEEELSLEDVQAELQRVEEEIRALEP--------VNmLAIQEYEEVLKRLDELKEKRAKLeeeRK 1003

                          410       420       430
                   ....*....|....*....|....*....|....*
gi 2462517825 1510 QLDDAHNKADNKEKTV-----INIQDQFHAIVQKL 1539
Cdd:TIGR02169 1004 AILERIEEYEKKKREVfmeafEAINENFNEIFAEL 1038
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
1528-1948 4.88e-05

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 48.61  E-value: 4.88e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1528 IQDQFHAIVQKLQAESEKQSLLLEERNKELISECNHLKERQYQYenekaerevvvRQLQQELADTLKKQSMSEASLEVTS 1607
Cdd:COG4717     47 LLERLEKEADELFKPQGRKPELNLKELKELEEELKEAEEKEEEY-----------AELQEELEELEEELEELEAELEELR 115

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1608 RYRINLEDETQ--DLKKKLGQIRNQLQEAQDRHTEAVrcaEKMQDHKQkLEKDNAKLKVTVKKQMDKIEELQKNLLNANL 1685
Cdd:COG4717    116 EELEKLEKLLQllPLYQELEALEAELAELPERLEELE---ERLEELRE-LEEELEELEAELAELQEELEELLEQLSLATE 191

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1686 SEDE--KEQLKKLMELKQSLECNLDQEMKKNVELEREITGFKNLLKMTRKKLNEYENGEFSFHGDLKTSQFEMDIQINKL 1763
Cdd:COG4717    192 EELQdlAEELEELQQRLAELEEELEEAQEELEELEEELEQLENELEAAALEERLKEARLLLLIAAALLALLGLGGSLLSL 271

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1764 KHKIDDLTAELETAGSKCLHLDTKNQILQEELLSMKTVQKKCEKLQKNKKK--LEQEVINLRSHIERNMVELGQVKQYKQ 1841
Cdd:COG4717    272 ILTIAGVLFLVLGLLALLFLLLAREKASLGKEAEELQALPALEELEEEELEelLAALGLPPDLSPEELLELLDRIEELQE 351

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1842 EIEERARQEIAEKLKEVNLFLQA--QAASQENLEQFRE-----NNFASMKSQMELRIKDLESELSKIKTSQEDFNKTELE 1914
Cdd:COG4717    352 LLREAEELEEELQLEELEQEIAAllAEAGVEDEEELRAaleqaEEYQELKEELEELEEQLEELLGELEELLEALDEEELE 431

                          410       420       430
                   ....*....|....*....|....*....|....
gi 2462517825 1915 KYKQLYLEELkvrKSLSSKLTKTNERLAEVNTKL 1948
Cdd:COG4717    432 EELEELEEEL---EELEEELEELREELAELEAEL 462
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
1071-1552 4.93e-05

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 48.61  E-value: 4.93e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1071 LLIEQLGmecKDSVSLLKIQDaalsceRLLELKKNHCELLTVKIKKMEDKvnvlQRELSETKEIKSQLEHQKVEWERELC 1150
Cdd:COG4717     46 MLLERLE---KEADELFKPQG------RKPELNLKELKELEEELKEAEEK----EEEYAELQEELEELEEELEELEAELE 112

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1151 SLRFSLNQEEEKRRNADTL--YEKIREQLRRKEEQYRkevEVKQQLElSLQTLEMELRTVKSNLNQVVQERNDAQRQLSR 1228
Cdd:COG4717    113 ELREELEKLEKLLQLLPLYqeLEALEAELAELPERLE---ELEERLE-ELRELEEELEELEAELAELQEELEELLEQLSL 188

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1229 EQNARMLQDGILTNHLSKQKEIEMAQKKMNSENSHSHEEEKDLSHKNSMLQEE------------IAMLRLEIDTIKNQN 1296
Cdd:COG4717    189 ATEEELQDLAEELEELQQRLAELEEELEEAQEELEELEEELEQLENELEAAALeerlkearllllIAAALLALLGLGGSL 268

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1297 QEKEKKCFEDLKIVKEKNEDLQKTIKQNEETLTQTISQYNGRLSVLTAENAMLNSKLENEKQSKERLEAEVESYHSRLAA 1376
Cdd:COG4717    269 LSLILTIAGVLFLVLGLLALLFLLLAREKASLGKEAEELQALPALEELEEEELEELLAALGLPPDLSPEELLELLDRIEE 348

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1377 AIHDRDQSETSKRELELafQRARDECSRLQDKmnFDVSNLKDNNEILSQ--QLFKTESKLNSLEIEFHHTRDALRE--KT 1452
Cdd:COG4717    349 LQELLREAEELEEELQL--EELEQEIAALLAE--AGVEDEEELRAALEQaeEYQELKEELEELEEQLEELLGELEEllEA 424

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1453 LGLERVQKDLSQTQCQMKEMEQKYQNEQvkvnkyiGKQESVEERLSQLQSENML--LRQQLDDAHNKADNKEKTVINIQD 1530
Cdd:COG4717    425 LDEEELEEELEELEEELEELEEELEELR-------EELAELEAELEQLEEDGELaeLLQELEELKAELRELAEEWAALKL 497

                          490       500
                   ....*....|....*....|...
gi 2462517825 1531 QFHAIVQKLQ-AESEKQSLLLEE 1552
Cdd:COG4717    498 ALELLEEAREeYREERLPPVLER 520
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
1361-1924 5.89e-05

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 48.50  E-value: 5.89e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1361 ERLEAEVESYHSRLAAAIHDRDQSETSKR--ELELAFQRARDECSRLQDKMNFDVSNLKDNNEILSQQLFKTEsKLNSLE 1438
Cdd:PRK02224   179 ERVLSDQRGSLDQLKAQIEEKEEKDLHERlnGLESELAELDEEIERYEEQREQARETRDEADEVLEEHEERRE-ELETLE 257

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1439 IEFhhtrDALREKTLGLERVQKDLSQT----QCQMKEMEQKYQNEQVKVNKYIGKQESVEERLSQLQSENMLLRQQLDDA 1514
Cdd:PRK02224   258 AEI----EDLRETIAETEREREELAEEvrdlRERLEELEEERDDLLAEAGLDDADAEAVEARREELEDRDEELRDRLEEC 333

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1515 HNKADNKEKtviniqdqfhaivqklQAESEKQSLL-LEERNKELISECNHLKERQYQYENEKAEREVVVRQLQQELADTL 1593
Cdd:PRK02224   334 RVAAQAHNE----------------EAESLREDADdLEERAEELREEAAELESELEEAREAVEDRREEIEELEEEIEELR 397

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1594 KKQSMSEASLEVTSRYRINLEDETQDLKKKLGQIRNQLQEAQDRHTEAVR------CAEKMQDHKQKLEKDnaklkvTVK 1667
Cdd:PRK02224   398 ERFGDAPVDLGNAEDFLEELREERDELREREAELEATLRTARERVEEAEAlleagkCPECGQPVEGSPHVE------TIE 471

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1668 KQMDKIEELqknllnanlsEDEKEQLK-KLMELKQSLEcnldqEMKKNVELEREITGFKNLLKMTRKKLNEYENGefsfh 1746
Cdd:PRK02224   472 EDRERVEEL----------EAELEDLEeEVEEVEERLE-----RAEDLVEAEDRIERLEERREDLEELIAERRET----- 531

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1747 gdlktsQFEMDIQINKLKHKIDDLTAELETAGSKCLHLDTKNQILQEELlsmktvqKKCE-KLQKNKKKLEQevinlrsh 1825
Cdd:PRK02224   532 ------IEEKRERAEELRERAAELEAEAEEKREAAAEAEEEAEEAREEV-------AELNsKLAELKERIES-------- 590

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1826 IERNMVELGQVKQYKQEIEERA--RQEIAEKLKEvnlflqaqaaSQENLEQFREnnfasmksqmelRIKDLESEL--SKI 1901
Cdd:PRK02224   591 LERIRTLLAAIADAEDEIERLRekREALAELNDE----------RRERLAEKRE------------RKRELEAEFdeARI 648

                          570       580
                   ....*....|....*....|...
gi 2462517825 1902 KTSQEDfnKTELEKYKQLYLEEL 1924
Cdd:PRK02224   649 EEARED--KERAEEYLEQVEEKL 669
PRK05771 PRK05771
V-type ATP synthase subunit I; Validated
 1664-1938 6.62e-05

V-type ATP synthase subunit I; Validated


Pssm-ID: 235600 [Multi-domain]  Cd Length: 646  Bit Score: 48.00  E-value: 6.62e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1664 VTVKKQMDK-IEELQKnlLNA----NLSEDEK-EQLKKLMELKQSLECNLDQeMKKNVELEReiTGFKNLLKMTRKKLNE 1737
Cdd:PRK05771    12 VTLKSYKDEvLEALHE--LGVvhieDLKEELSnERLRKLRSLLTKLSEALDK-LRSYLPKLN--PLREEKKKVSVKSLEE 86

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1738 YENGEFSFHGDLKTSQFEMDIQINKLKHKIDDLTAELETAgSKCLHLDtknqILQEELLSMKTVQKKCEKLQKNKKKLEQ 1817
Cdd:PRK05771    87 LIKDVEEELEKIEKEIKELEEEISELENEIKELEQEIERL-EPWGNFD----LDLSLLLGFKYVSVFVGTVPEDKLEELK 161

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1818 EVINLRSHIErnmvelgqVKQYKQE------IEERARQEIAEKLKEVNLflqaqaasqENLEQFRENNFASMKSQMELRI 1891
Cdd:PRK05771   162 LESDVENVEY--------ISTDKGYvyvvvvVLKELSDEVEEELKKLGF---------ERLELEEEGTPSELIREIKEEL 224

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1892 KDLESELSKIKTSQEDFNKtELEKYKQLYLEEL---KVRKSLSSKLTKTN 1938
Cdd:PRK05771   225 EEIEKERESLLEELKELAK-KYLEELLALYEYLeieLERAEALSKFLKTD 273
PRK11281 PRK11281
mechanosensitive channel MscK;
1310-1514 6.93e-05

mechanosensitive channel MscK;


Pssm-ID: 236892 [Multi-domain]  Cd Length: 1113  Bit Score: 48.37  E-value: 6.93e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1310 VKEKNEDLQKTIKQneetLTQTISQYNGRLSVLTAEN-------------AMLNSKLENEKQSKERLEAEVESYHSRLAA 1376
Cdd:PRK11281    78 QKEETEQLKQQLAQ----APAKLRQAQAELEALKDDNdeetretlstlslRQLESRLAQTLDQLQNAQNDLAEYNSQLVS 153

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1377 AihdRDQSETSKRELELAFQRArdecsrlqDKMNFDVSNLKDNNEILS---QQLFKTESKLNSLEIEFHHT--------- 1444
Cdd:PRK11281   154 L---QTQPERAQAALYANSQRL--------QQIRNLLKGGKVGGKALRpsqRVLLQAEQALLNAQNDLQRKslegntqlq 222

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1445 ------RDALREKTLGLERV---------QKDLSQTQCQMKEMEQKYQNEQVKVNKYIGKQESVEERLSQ---------- 1499
Cdd:PRK11281   223 dllqkqRDYLTARIQRLEHQlqllqeainSKRLTLSEKTVQEAQSQDEAARIQANPLVAQELEINLQLSQrllkatekln 302

                          250
                   ....*....|....*.
gi 2462517825 1500 -LQSENMLLRQQLDDA 1514
Cdd:PRK11281   303 tLTQQNLRVKNWLDRL 318
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
1097-1545 7.79e-05

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 48.14  E-value: 7.79e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1097 ERLLELKKNHCELltVKIKKMEDKVNVLQRELSETKEIKSQLEHQKVEWERELCSLRFSLNQEEEKRRNADTLYEKIREQ 1176
Cdd:PRK03918   273 KEIEELEEKVKEL--KELKEKAEEYIKLSEFYEEYLDELREIEKRLSRLEEEINGIEERIKELEEKEERLEELKKKLKEL 350

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1177 LRRKEEqyrkevevkqqLELSLQTLEmELRTVKSNLNQVVQERNDaqrqLSREQNARMLQDgiltnhLSKQK-EIEMAQK 1255
Cdd:PRK03918   351 EKRLEE-----------LEERHELYE-EAKAKKEELERLKKRLTG----LTPEKLEKELEE------LEKAKeEIEEEIS 408

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1256 KMNSENSHSHEEEKDLSHKNSMLQ-------------------EEIAMLRLEIDTIKNQNQEKEKKcFEDLKIVKEKNED 1316
Cdd:PRK03918   409 KITARIGELKKEIKELKKAIEELKkakgkcpvcgrelteehrkELLEEYTAELKRIEKELKEIEEK-ERKLRKELRELEK 487

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1317 L---QKTIKQNEETLTQtISQYNGRLSVLTAENamLNSKLENEKQSKERLeAEVESYHSRLAAAIHDRDQSETSKRELEL 1393
Cdd:PRK03918   488 VlkkESELIKLKELAEQ-LKELEEKLKKYNLEE--LEKKAEEYEKLKEKL-IKLKGEIKSLKKELEKLEELKKKLAELEK 563

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1394 AFQRARDECSRLQDKM-NFDVSNLKDNNEILSQ---------QLFKTESKLNSLEIEFHHTRDALREKTLGLERVQKDLS 1463
Cdd:PRK03918   564 KLDELEEELAELLKELeELGFESVEELEERLKElepfyneylELKDAEKELEREEKELKKLEEELDKAFEELAETEKRLE 643

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1464 QTQCQMKEMEQKYQNEqvkvnkyigKQESVEERLSQLQSENMLLRQQLDDAHNKADNKEKTVINIQDQFHAIvQKLQAES 1543
Cdd:PRK03918   644 ELRKELEELEKKYSEE---------EYEELREEYLELSRELAGLRAELEELEKRREEIKKTLEKLKEELEER-EKAKKEL 713


                   ..
gi 2462517825 1544 EK 1545
Cdd:PRK03918   714 EK 715
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
1490-1740 9.71e-05

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 47.70  E-value: 9.71e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1490 QESVEERLSQLQSENMLLR----QQLDDAHNKADNKEKTVINiqdqfhAIVQKLQAESEKQSLLLE----ERNKELISE- 1560
Cdd:COG3206     80 DSPLETQIEILKSRPVLERvvdkLNLDEDPLGEEASREAAIE------RLRKNLTVEPVKGSNVIEisytSPDPELAAAv 153

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1561 CNHLKE--RQYQYENEKAEREVVVRQLQQELADTLKKQSMSEASLEvtsRYR-----INLEDETQDLKKKLGQIRNQLQE 1633
Cdd:COG3206    154 ANALAEayLEQNLELRREEARKALEFLEEQLPELRKELEEAEAALE---EFRqknglVDLSEEAKLLLQQLSELESQLAE 230

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1634 AQDRHTEAVRCAEKMQDHKQKLEKDNAKLK--VTVKKQMDKIEELQKNLlnANLSE---DEKEQLKKLMELKQSLECNLD 1708
Cdd:COG3206    231 ARAELAEAEARLAALRAQLGSGPDALPELLqsPVIQQLRAQLAELEAEL--AELSArytPNHPDVIALRAQIAALRAQLQ 308

                          250       260       270
                   ....*....|....*....|....*....|...
gi 2462517825 1709 QEMKKN-VELEREITGFKNLLKMTRKKLNEYEN 1740
Cdd:COG3206    309 QEAQRIlASLEAELEALQAREASLQAQLAQLEA 341
Ank_5 pfam13857
Ankyrin repeats (many copies);
98-153 1.07e-04

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 41.95  E-value: 1.07e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 2462517825   98 LLVDRKCQLNVCDNENRTALMKAVQCQEEKCATILLEHGADPNLADVHGNTALHYA 153
Cdd:pfam13857    1 LLEHGPIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
EzrA pfam06160
Septation ring formation regulator, EzrA; During the bacterial cell cycle, the tubulin-like ...
 1621-1953 1.10e-04

Septation ring formation regulator, EzrA; During the bacterial cell cycle, the tubulin-like cell-division protein FtsZ polymerizes into a ring structure that establishes the location of the nascent division site. EzrA modulates the frequency and position of FtsZ ring formation. The structure contains 5 spectrin like alpha helical repeats.


Pssm-ID: 428797 [Multi-domain]  Cd Length: 542  Bit Score: 47.16  E-value: 1.10e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1621 KKKLGQIRNQLQEAQDRhteavrcAEKMQDHKQKLEKDNAKLKVTVKKQMDKIEELQKNLLNANLS-------------- 1686
Cdd:pfam06160   85 KKALDEIEELLDDIEED-------IKQILEELDELLESEEKNREEVEELKDKYRELRKTLLANRFSygpaidelekqlae 157

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1687 -EDEKEQLKKLMELKQSLECN--LDQEMKKNVELEREITGFKNLLKMTRK----KLNEYENGefsfHGDLKTSQF----- 1754
Cdd:pfam06160  158 iEEEFSQFEELTESGDYLEARevLEKLEEETDALEELMEDIPPLYEELKTelpdQLEELKEG----YREMEEEGYalehl 233

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1755 EMDIQINKLKHKIDDLTAELETagskcLHLDT---KNQILQEELLSM-----------KTVQKKCEKLQKNKKKLEQEVI 1820
Cdd:pfam06160  234 NVDKEIQQLEEQLEENLALLEN-----LELDEaeeALEEIEERIDQLydllekevdakKYVEKNLPEIEDYLEHAEEQNK 308

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1821 NLRSHIER-------NMVELGQVKQYKQEIE--ERARQEIAEKLKEvnlflQAQAasqenleqfrennfasmKSQMELRI 1891
Cdd:pfam06160  309 ELKEELERvqqsytlNENELERVRGLEKQLEelEKRYDEIVERLEE-----KEVA-----------------YSELQEEL 366

                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462517825 1892 KDLESELSKIKTSQEDFNktelEKYKQLYLEELKVRKslssKLTKTNERLAEVntKLLVEKQ 1953
Cdd:pfam06160  367 EEILEQLEEIEEEQEEFK----ESLQSLRKDELEARE----KLDEFKLELREI--KRLVEKS 418
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
1113-1472 1.27e-04

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 47.22  E-value: 1.27e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1113 KIKKMEDKVNVLQRELSETKEIKSQLEHQKVEWERELCSLRFSLNQEEEKRRNADTlyekiREQLRRKEEQYRkevevkq 1192
Cdd:COG4913    611 KLAALEAELAELEEELAEAEERLEALEAELDALQERREALQRLAEYSWDEIDVASA-----EREIAELEAELE------- 678

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1193 QLELS---LQTLEMELRTVKSNLNQVVQERNDAQRQLSREQNARmlqdgiltnhlsKQKEIEMAQKKMNSENSHSHEEEK 1269
Cdd:COG4913    679 RLDASsddLAALEEQLEELEAELEELEEELDELKGEIGRLEKEL------------EQAEEELDELQDRLEAAEDLARLE 746

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1270 DLSHKNSMLQEEIAmlrleidtiknqnQEKEKKCFEDLkivKEKNEDLQKTIKQNEETLTQTISQYNGRLSVLTAE---- 1345
Cdd:COG4913    747 LRALLEERFAAALG-------------DAVERELRENL---EERIDALRARLNRAEEELERAMRAFNREWPAETADldad 810

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1346 -------NAMLNsKLENekqskERLEAevesYHSRLAAAIHdrDQSETSKRELELAFQRARDECSRlqdkmnfdvsNLKD 1418
Cdd:COG4913    811 leslpeyLALLD-RLEE-----DGLPE----YEERFKELLN--ENSIEFVADLLSKLRRAIREIKE----------RIDP 868

                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462517825 1419 NNEILSQQLFKTESKLnSLEI------EFHHTRDALREKTLGLERVQKDLSQTQC-QMKEM 1472
Cdd:COG4913    869 LNDSLKRIPFGPGRYL-RLEArprpdpEVREFRQELRAVTSGASLFDEELSEARFaALKRL 928
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 1615-1887 1.32e-04

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 46.68  E-value: 1.32e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1615 DETQDLKKKLGQIRNQLQEAQDRHTEAVRCAEKMQDHKQKLEKDNAKLKVTVKKQMDKIEELQKNLlnANLSEDEKEQLK 1694
Cdd:COG4942     20 DAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAEL--AELEKEIAELRA 97

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1695 KLMELKQSLEcnldqemkknvelereitgfKNLLKMTRKKLNEYENGEFSFHGDLKTSQFEMDIQ--INKLKHKIDDLTA 1772
Cdd:COG4942     98 ELEAQKEELA--------------------ELLRALYRLGRQPPLALLLSPEDFLDAVRRLQYLKylAPARREQAEELRA 157

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1773 ELETagskclhLDTKNQILQEELLSMKTVQKKCEKLQKNKKKLEQEVINLRSHIERNMVELGQVKQYKQEIEERARQEIA 1852
Cdd:COG4942    158 DLAE-------LAALRAELEAERAELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIA 230

                          250       260       270
                   ....*....|....*....|....*....|....*
gi 2462517825 1853 EklkevnlfLQAQAASQEnlEQFRENNFASMKSQM 1887
Cdd:COG4942    231 R--------LEAEAAAAA--ERTPAAGFAALKGKL 255
rad50 TIGR00606
rad50; All proteins in this family for which functions are known are involvedin recombination, ...
 874-1771 1.70e-04

rad50; All proteins in this family for which functions are known are involvedin recombination, recombinational repair, and/or non-homologous end joining.They are components of an exonuclease complex with MRE11 homologs. This family is distantly related to the SbcC family of bacterial proteins.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).


Pssm-ID: 129694 [Multi-domain]  Cd Length: 1311  Bit Score: 46.96  E-value: 1.70e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825  874 EELQQDMQRFKNEIGMLKVEFQALEKEKVQLQK---EVEEERKKHRNNEMEVSANIHDGATDDAEDDDDDDGLIQKRKSG 950
Cdd:TIGR00606  251 KNRLKEIEHNLSKIMKLDNEIKALKSRKKQMEKdnsELELKMEKVFQGTDEQLNDLYHNHQRTVREKERELVDCQRELEK 330

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825  951 ETDHQQFPRKENKEYASGPA-LQMK-EVKSTEKEKRTSKESVNSPVFGKASLLTGGLLQVDDDSSLS---EIDEDEGRPT 1025
Cdd:TIGR00606  331 LNKERRLLNQEKTELLVEQGrLQLQaDRHQEHIRARDSLIQSLATRLELDGFERGPFSERQIKNFHTlviERQEDEAKTA 410

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1026 KK-----TSNEKNKVKNQIQSMDDVDDLTQSSETASEDCELPHSSYKNFMLLIEQLGMECKDsvsLLKIQDAALSCERLL 1100
Cdd:TIGR00606  411 AQlcadlQSKERLKQEQADEIRDEKKGLGRTIELKKEILEKKQEELKFVIKELQQLEGSSDR---ILELDQELRKAEREL 487

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1101 EL--KKNHCELLTVKIKKMEDKVNVLQRELSETKEIKSQLEHQKVEWERELCSLRFSLNQEEEKRRNADTLYEKIREQL- 1177
Cdd:TIGR00606  488 SKaeKNSLTETLKKEVKSLQNEKADLDRKLRKLDQEMEQLNHHTTTRTQMEMLTKDKMDKDEQIRKIKSRHSDELTSLLg 567

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1178 -----RRKEEQYRKEVEVKQQLELSLQTLEMELRTVKSNLNQVVQERNDAQRQLSReqnarmLQDGILTNHLSKQKEIEM 1252
Cdd:TIGR00606  568 yfpnkKQLEDWLHSKSKEINQTRDRLAKLNKELASLEQNKNHINNELESKEEQLSS------YEDKLFDVCGSQDEESDL 641

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1253 AQKKmnsenshshEEEKDLSHKNSMLQEEIAMLRLEIDTIKNQNQEKEKKCFEDLKIVKEKNEdlqktikqneetltqTI 1332
Cdd:TIGR00606  642 ERLK---------EEIEKSSKQRAMLAGATAVYSQFITQLTDENQSCCPVCQRVFQTEAELQE---------------FI 697

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1333 SQYNGRLSVLTAENAMLNSKLENEKQSKERLEAEVESyhsrlaaaihdrDQSETSKRELELAFQRARDEcsrlqdKMNFD 1412
Cdd:TIGR00606  698 SDLQSKLRLAPDKLKSTESELKKKEKRRDEMLGLAPG------------RQSIIDLKEKEIPELRNKLQ------KVNRD 759

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1413 VSNLKDNNEilsqqlfKTESKLNSLEIEFHHTRDALREKTLglervqkdLSQTQCQMKEMEQKYQNEQVKVNKYIG---- 1488
Cdd:TIGR00606  760 IQRLKNDIE-------EQETLLGTIMPEEESAKVCLTDVTI--------MERFQMELKDVERKIAQQAAKLQGSDLdrtv 824

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1489 -----KQESVEERLSQLQSENMLLRQQLDDAHNKADNKEKTVINIQDQFHAIVQKLQaesekQSLLLEERNKELISECNH 1563
Cdd:TIGR00606  825 qqvnqEKQEKQHELDTVVSKIELNRKLIQDQQEQIQHLKSKTNELKSEKLQIGTNLQ-----RRQQFEEQLVELSTEVQS 899

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1564 LKERQYQYENEKAEREVVVRQLQQELADTLKKQSMSEASlevtsryrinLEDETQDLKKKLGQ-------IRNQLQEAQD 1636
Cdd:TIGR00606  900 LIREIKDAKEQDSPLETFLEKDQQEKEELISSKETSNKK----------AQDKVNDIKEKVKNihgymkdIENKIQDGKD 969

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1637 RH--------TEAVRCAEKMQDHKQKLEKDNAKLKVTVKKQMDKIEELQKNLLNANLSEDEKEQLKKLME-LKQSLECNL 1707
Cdd:TIGR00606  970 DYlkqketelNTVNAQLEECEKHQEKINEDMRLMRQDIDTQKIQERWLQDNLTLRKRENELKEVEEELKQhLKEMGQMQV 1049

                          890       900       910       920       930       940       950
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462517825 1708 DQEMKKNVELEREITGFKNLLKMTRKKLNEYENGEFSFHGDLKTSQF--------EMDIQINKLKHKIDDLT 1771
Cdd:TIGR00606 1050 LQMKQEHQKLEENIDLIKRNHVLALGRQKGYEKEIKHFKKELREPQFrdaeekyrEMMIVMRTTELVNKDLD 1121
PRK12704 PRK12704
phosphodiesterase; Provisional
 1570-1698 1.97e-04

phosphodiesterase; Provisional


Pssm-ID: 237177 [Multi-domain]  Cd Length: 520  Bit Score: 46.31  E-value: 1.97e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1570 QYENEKAEREVVVRQLQQElADTLKKQSMSEASLEVtSRYRINLEDETQDLKKKLGQIRNQLQ---EAQDRHTEAVrcaE 1646
Cdd:PRK12704    32 KIKEAEEEAKRILEEAKKE-AEAIKKEALLEAKEEI-HKLRNEFEKELRERRNELQKLEKRLLqkeENLDRKLELL---E 106

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 2462517825 1647 KMQDHKQKLEKDNAKLKVTVKKQMDKIEELQKNLLN-----ANLSEDE-KEQLKKLME 1698
Cdd:PRK12704   107 KREEELEKKEKELEQKQQELEKKEEELEELIEEQLQeleriSGLTAEEaKEILLEKVE 164
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 81-111 2.00e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 40.35  E-value: 2.00e-04
                           10        20        30
                   ....*....|....*....|....*....|..
gi 2462517825   81 RTALHLACA-NGHPEVVTLLVDRKCQLNVCDN 111
Cdd:pfam00023    3 NTPLHLAAGrRGNLEIVKLLLSKGADVNARDK 34
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 1473-1692 2.18e-04

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 45.98  E-value: 2.18e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1473 EQKYQNEQVKVNKYIGKQESVEERLSQLQsenmllrQQLDDAHNKADNKEKTVINIQDQfhaiVQKLQAESEKQSLLLEE 1552
Cdd:COG3883     15 DPQIQAKQKELSELQAELEAAQAELDALQ-------AELEELNEEYNELQAELEALQAE----IDKLQAEIAEAEAEIEE 83

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1553 RNKELisecnhlKER-QYQYENEKA-----------------EREVVVRQLQQELADTLKKQSMSEASLEvtsRYRINLE 1614
Cdd:COG3883     84 RREEL-------GERaRALYRSGGSvsyldvllgsesfsdflDRLSALSKIADADADLLEELKADKAELE---AKKAELE 153

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2462517825 1615 DETQDLKKKLGQIRNQLQEAQDRHTEAVRCAEKMQDHKQKLEKDNAKLKVTVKKQMDKIEELQKNLLNANLSEDEKEQ 1692
Cdd:COG3883    154 AKLAELEALKAELEAAKAELEAQQAEQEALLAQLSAEEAAAEAQLAELEAELAAAEAAAAAAAAAAAAAAAAAAAAAA 231
TRPV cd21882
Transient Receptor Potential channel, Vanilloid subfamily (TRPV); The vanilloid TRP subfamily ...
 81-202 2.39e-04

Transient Receptor Potential channel, Vanilloid subfamily (TRPV); The vanilloid TRP subfamily (TRPV), named after the vanilloid receptor 1 (TRPV1), consists of six members: four thermo-sensing channels (TRPV1, TRPV2, TRPV3, and TRPV4) and two Ca2+ selective channels (TRPV5 and TRPV6). The calcium-selective channels TRPV5 and TRPV6 can be heterotetramers and are important for general Ca2+ homeostasis. All four channels within the TRPV1-4 group show temperature-invoked currents when expressed in heterologous cell systems, ranging from activation at ~25C for TRPV4 to ~52C for TRPV2. The structure of TRPV shows the typical topology features of all Transient Receptor Potential (TRP) ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains. The TRP family consists of membrane proteins that function as ion channels that communicate between the cell and its environment, by a vast array of physical or chemical stimuli, including radiation (in the form of temperature, infrared ,or light) and pressure (osmotic or mechanical). TRP channels are formed by a tetrameric complex of channel subunits. Based on sequence identity, the mammalian TRP channel family is classified into six subfamilies, with significant sequence similarity within the transmembrane domains, but very low similarity in their N- and C-terminal cytoplasmic regions. The six subfamilies are named based on their first member: TRPC (canonical), TRPV (vanilloid), TRPM (melastatin), TRPA (ankyrin), TRPML (mucolipin), and TRPP (polycystic).


Pssm-ID: 411975 [Multi-domain]  Cd Length: 600  Bit Score: 46.03  E-value: 2.39e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825   81 RTALHLACANGHPEVVTLLVDRKC--QLNVCDNENRTA-----------LMKAVQCQEEKCATILLEHGADP---NLADV 144
Cdd:cd21882     74 QTALHIAIENRNLNLVRLLVENGAdvSARATGRFFRKSpgnlfyfgelpLSLAACTNQEEIVRLLLENGAQPaalEAQDS 153

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2462517825  145 HGNTALHYAVYNED---------ISVATKLLLYDANI-------EAKNKDDLTPLLLAVSGKKQQMVEFLIKKK 202
Cdd:cd21882    154 LGNTVLHALVLQADntpensafvCQMYNLLLSYGAHLdptqqleEIPNHQGLTPLKLAAVEGKIVMFQHILQRE 227
COG1340 COG1340
Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown];
1550-1858 2.47e-04

Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown];


Pssm-ID: 440951 [Multi-domain]  Cd Length: 297  Bit Score: 45.29  E-value: 2.47e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1550 LEERNKELISECNHLKERQYQYENEKAErevvVRQLQQELADTLKKqsmseaslevtsryrinLEDETQDLKKKLGQIRN 1629
Cdd:COG1340     13 LEEKIEELREEIEELKEKRDELNEELKE----LAEKRDELNAQVKE-----------------LREEAQELREKRDELNE 71

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1630 QLQEAQDRHTEAvrcAEKMQDHKQKLEKDNAKLKVTVKKQMD------KIEELQKNLLNANLS-EDEKEQLKKLMELKQS 1702
Cdd:COG1340     72 KVKELKEERDEL---NEKLNELREELDELRKELAELNKAGGSidklrkEIERLEWRQQTEVLSpEEEKELVEKIKELEKE 148

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1703 LEcnldqEMKKNVELEREITGFKNLLKMTRKKLNEYengefsfHGDLKTSQFEMDI---QINKLKHKIDDLTAELETAgs 1779
Cdd:COG1340    149 LE-----KAKKALEKNEKLKELRAELKELRKEAEEI-------HKKIKELAEEAQElheEMIELYKEADELRKEADEL-- 214

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2462517825 1780 kclhldtknqilqeellsmktvQKKCEKLQKNKKKLEQEVINLRSHIERNMVELGQVKQYKQEIEERARQEIAEKLKEV 1858
Cdd:COG1340    215 ----------------------HKEIVEAQEKADELHEEIIELQKELRELRKELKKLRKKQRALKREKEKEELEEKAEE 271
MAD pfam05557
Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint ...
 1276-1858 2.71e-04

Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint (Mitotic arrest deficient or MAD) proteins. The mitotic spindle checkpoint monitors proper attachment of the bipolar spindle to the kinetochores of aligned sister chromatids and causes a cell cycle arrest in prometaphase when failures occur. Multiple components of the mitotic spindle checkpoint have been identified in yeast and higher eukaryotes. In S.cerevisiae, the existence of a Mad1-dependent complex containing Mad2, Mad3, Bub3 and Cdc20 has been demonstrated.


Pssm-ID: 461677 [Multi-domain]  Cd Length: 660  Bit Score: 45.89  E-value: 2.71e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1276 SMLQEEIAMLRLEIDTIKNQNQEKEKKCFEDLKIVKEKNEDLQKTIKQNE--ETLTQTISQYNGRLSVLTAENAMLNSKL 1353
Cdd:pfam05557   12 SQLQNEKKQMELEHKRARIELEKKASALKRQLDRESDRNQELQKRIRLLEkrEAEAEEALREQAELNRLKKKYLEALNKK 91

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1354 ENEKQSKerlEAEVESYHSRLAAAIHDRdQSETSKRELELAFQRARDECSR----LQDKMNFDVSNLKDNNEILSQQLFK 1429
Cdd:pfam05557   92 LNEKESQ---LADAREVISCLKNELSEL-RRQIQRAELELQSTNSELEELQerldLLKAKASEAEQLRQNLEKQQSSLAE 167

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1430 TESKLNSLEIEFH-HTRDALrektlglerVQKDLSQTQCQMKEMEqkyqneqvkvnKYIGKQESVEERLSQLQSENMLLR 1508
Cdd:pfam05557  168 AEQRIKELEFEIQsQEQDSE---------IVKNSKSELARIPELE-----------KELERLREHNKHLNENIENKLLLK 227

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1509 QQLDDAHNKADNKEKT---VINIQDQFHAIVQKLQA-ESEKQSLLLE--------ERNKELISECNHLKERQYQYENEKA 1576
Cdd:pfam05557  228 EEVEDLKRKLEREEKYreeAATLELEKEKLEQELQSwVKLAQDTGLNlrspedlsRRIEQLQQREIVLKEENSSLTSSAR 307

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1577 EREVVVRQLQQELADTLKKqsmseaslevtsryrinledeTQDLKKKLGQIRNQLQEAQDRhteavrcaekmqdhkqkle 1656
Cdd:pfam05557  308 QLEKARRELEQELAQYLKK---------------------IEDLNKKLKRHKALVRRLQRR------------------- 347

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1657 kdnaklKVTVKKQMDKIEELQKN----LLNANLSEDEKEQLKKLMELKQSLEcNLDQEMKKNVE-LEREITGFKNLLKM- 1730
Cdd:pfam05557  348 ------VLLLTKERDGYRAILESydkeLTMSNYSPQLLERIEEAEDMTQKMQ-AHNEEMEAQLSvAEEELGGYKQQAQTl 420

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1731 -----TRKKLNEYENGEFSFHG--DLKTSQFEMDIQINKLKHKIDDLTAELEtagSKCLHLDTKNQILQEELLSMKTVQK 1803
Cdd:pfam05557  421 erelqALRQQESLADPSYSKEEvdSLRRKLETLELERQRLREQKNELEMELE---RRCLQGDYDPKKTKVLHLSMNPAAE 497

                          570       580       590       600       610
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 2462517825 1804 KCEKLQKNKKKLEQEVINLRSHIERNMVELGQVKQYKQEIEERARQEIAEKLKEV 1858
Cdd:pfam05557  498 AYQQRKNQLEKLQAEIERLKRLLKKLEDDLEQVLRLPETTSTMNFKEVLDLRKEL 552
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
 877-1716 3.18e-04

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 45.94  E-value: 3.18e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825  877 QQDMQRFKNEIGMLKVEFQALEKEKVQLQK----------EVEEERKKHRNNEMEVSANIHDGATDDAEDDDDDDGLIQK 946
Cdd:pfam01576   18 KERQQKAESELKELEKKHQQLCEEKNALQEqlqaetelcaEAEEMRARLAARKQELEEILHELESRLEEEEERSQQLQNE 97

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825  947 RKSGETDHQQFPRKENKEYASGPALQMKEVKSTEKEKRTSKEsvnspvfgkaslltggLLQVDDDSSlseidedegrptk 1026
Cdd:pfam01576   98 KKKMQQHIQDLEEQLDEEEAARQKLQLEKVTTEAKIKKLEED----------------ILLLEDQNS------------- 148

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1027 KTSNEKNKVKNQIQSMDDvddltqssetasedcelphssyknfmllieQLGMECKDSVSLLKIQDAALSCERLLELKKNH 1106
Cdd:pfam01576  149 KLSKERKLLEERISEFTS------------------------------NLAEEEEKAKSLSKLKNKHEAMISDLEERLKK 198

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1107 CELLTVKIKKMEDKvnvLQRELSETKEiksqlehQKVEWERELCSLRFSLNQEEEKRRNAdtlyekireQLRRKEEQYRK 1186
Cdd:pfam01576  199 EEKGRQELEKAKRK---LEGESTDLQE-------QIAELQAQIAELRAQLAKKEEELQAA---------LARLEEETAQK 259

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1187 EVEVKQQLELSLQTLEmelrtVKSNLNQVVQERNDAQRQ---LSREQNA--RMLQDGILT----NHLSKQKEIEMAQ-KK 1256
Cdd:pfam01576  260 NNALKKIRELEAQISE-----LQEDLESERAARNKAEKQrrdLGEELEAlkTELEDTLDTtaaqQELRSKREQEVTElKK 334

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1257 MNSENSHSHEEE-KDLSHKNSMLQEEIAMlRLEIDTIKNQNQEKEKKCFEdlkivkEKNEDLQKTIKqneeTLTQTISQY 1335
Cdd:pfam01576  335 ALEEETRSHEAQlQEMRQKHTQALEELTE-QLEQAKRNKANLEKAKQALE------SENAELQAELR----TLQQAKQDS 403

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1336 NGRLSVLTAENAMLNSKL-ENEKQSKERLEaevesyhsRLAAAIHDRDQSETSKRELELAFQRARDECSRLQdkmnfdvS 1414
Cdd:pfam01576  404 EHKRKKLEGQLQELQARLsESERQRAELAE--------KLSKLQSELESVSSLLNEAEGKNIKLSKDVSSLE-------S 468

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1415 NLKDNNEILS---QQLFKTESKLNSLEIEFHHTRDALREKTLGLERVQKDLSQTQCQMKEMEQKYQNEQvkvnkyiGKQE 1491
Cdd:pfam01576  469 QLQDTQELLQeetRQKLNLSTRLRQLEDERNSLQEQLEEEEEAKRNVERQLSTLQAQLSDMKKKLEEDA-------GTLE 541

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1492 SVEERLSQLQSENMLLRQQLDDAHNKADNKEKTVINIQ----------DQFHAIVQKLQAESEK-QSLLLEERNkelISE 1560
Cdd:pfam01576  542 ALEEGKKRLQRELEALTQQLEEKAAAYDKLEKTKNRLQqelddllvdlDHQRQLVSNLEKKQKKfDQMLAEEKA---ISA 618

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1561 cnhlkerQYQYENEKAEREV--------------------------VVRQLQQELADTLKKQSMSEASLEVTSRYRINLE 1614
Cdd:pfam01576  619 -------RYAEERDRAEAEAreketralslaraleealeakeelerTNKQLRAEMEDLVSSKDDVGKNVHELERSKRALE 691

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1615 DETQDLKKKLGQIRNQLQEAQDrhtEAVRCAEKMQDHKQKLEKDnakLKVTVKKQMDKIEELQKNL--LNANLsEDEKEQ 1692
Cdd:pfam01576  692 QQVEEMKTQLEELEDELQATED---AKLRLEVNMQALKAQFERD---LQARDEQGEEKRRQLVKQVreLEAEL-EDERKQ 764

                          890       900
                   ....*....|....*....|....
gi 2462517825 1693 LKKLMELKQSLECNLdQEMKKNVE 1716
Cdd:pfam01576  765 RAQAVAAKKKLELDL-KELEAQID 787
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 1461-1641 3.21e-04

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 45.21  E-value: 3.21e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1461 DLSQTQCQMKEMEQKYQNEQVKVNKYIGKQESVEERLSQLQSENMLLRQQLDDAHNKADNKEKTVINIQDQFHAIVQKLQ 1540
Cdd:COG3883     17 QIQAKQKELSELQAELEAAQAELDALQAELEELNEEYNELQAELEALQAEIDKLQAEIAEAEAEIEERREELGERARALY 96

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1541 AESEKQSLL---------------------LEERNKELISEcnhLKERQYQYENEKAEREVVVRQLQQELADTLKKQSMS 1599
Cdd:COG3883     97 RSGGSVSYLdvllgsesfsdfldrlsalskIADADADLLEE---LKADKAELEAKKAELEAKLAELEALKAELEAAKAEL 173

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|..
gi 2462517825 1600 EASLEVTSRYRINLEDETQDLKKKLGQIRNQLQEAQDRHTEA 1641
Cdd:COG3883    174 EAQQAEQEALLAQLSAEEAAAEAQLAELEAELAAAEAAAAAA 215
235kDa-fam TIGR01612
reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in ...
 1291-1916 3.46e-04

reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in plasmodium species alternately annotated as reticulocyte binding protein, 235-kDa family protein and rhoptry protein. Rhoptry protein is localized on the cell surface and is extremely large (although apparently lacking in repeat structure) and is important for the process of invasion of the RBCs by the parasite. These proteins are found in P. falciparum, P. vivax and P. yoelii.


Pssm-ID: 130673 [Multi-domain]  Cd Length: 2757  Bit Score: 46.20  E-value: 3.46e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1291 TIKNQNQEKEKKCFEDL--KIVKEKN--EDLQK---TIKQNEETLTQTISQYNGRLSVLTAENAMLNSKLENEKQSKERL 1363
Cdd:TIGR01612 1162 AISNDDPEEIEKKIENIvtKIDKKKNiyDEIKKllnEIAEIEKDKTSLEEVKGINLSYGKNLGKLFLEKIDEEKKKSEHM 1241

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1364 EAEVESYhsrlaaaIHDRDQSETSKRELELAFQRARDecsrLQDKMN-FDVSNLKDNNE-ILSQQLFKTESKLNSLEIEF 1441
Cdd:TIGR01612 1242 IKAMEAY-------IEDLDEIKEKSPEIENEMGIEMD----IKAEMEtFNISHDDDKDHhIISKKHDENISDIREKSLKI 1310

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1442 hhTRDALREKTLG--LERVQKDLSQTQCQMKEMEQkYQNEQ------VKVNKYIGKQESVEERLSQLQSENMLLRQQLDd 1513
Cdd:TIGR01612 1311 --IEDFSEESDINdiKKELQKNLLDAQKHNSDINL-YLNEIaniyniLKLNKIKKIIDEVKEYTKEIEENNKNIKDELD- 1386

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1514 ahnkadNKEKTVINIQDQFHAIVQKLQAESEKQSLLLEERNKELISECNHLKERQYQ----YENEKAEREVVVRQLQQ-E 1588
Cdd:TIGR01612 1387 ------KSEKLIKKIKDDINLEECKSKIESTLDDKDIDECIKKIKELKNHILSEESNidtyFKNADENNENVLLLFKNiE 1460

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1589 LADTLKKQSMSEASLEVTSRYRINLedetqdlkkklgqirNQLQEAQDRhteavrcaekmqDHKQKLEKDNAKlkvtvkK 1668
Cdd:TIGR01612 1461 MADNKSQHILKIKKDNATNDHDFNI---------------NELKEHIDK------------SKGCKDEADKNA------K 1507

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1669 QMDKIEELQKNLlnanlSEDEKEQLKKLMELkqSLECNLDQEMKKNVELEREITGFKNLLKM----TRKKLNEYENGEFS 1744
Cdd:TIGR01612 1508 AIEKNKELFEQY-----KKDVTELLNKYSAL--AIKNKFAKTKKDSEIIIKEIKDAHKKFILeaekSEQKIKEIKKEKFR 1580

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1745 FHGDL----KTSQFEMDIQ------------INKLKHKIDDLTAELETAGSK--CLHLDTKNQILQEELLSMKTVQKKCE 1806
Cdd:TIGR01612 1581 IEDDAakndKSNKAAIDIQlslenfenkflkISDIKKKINDCLKETESIEKKisSFSIDSQDTELKENGDNLNSLQEFLE 1660

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1807 KLQKNKKKLE---QEVINLRSHIERNMVElgqVKQYKQEIEerarQEIAEKLKEVNLflqaqaASQENLEqfrennfaSM 1883
Cdd:TIGR01612 1661 SLKDQKKNIEdkkKELDELDSEIEKIEID---VDQHKKNYE----IGIIEKIKEIAI------ANKEEIE--------SI 1719

                          650       660       670
                   ....*....|....*....|....*....|...
gi 2462517825 1884 KSQMELRIKDLESELSKIKTSQEDFNKtELEKY 1916
Cdd:TIGR01612 1720 KELIEPTIENLISSFNTNDLEGIDPNE-KLEEY 1751
Cast pfam10174
RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part ...
 1174-1838 3.50e-04

RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part of the CAZ (cytomatrix at the active zone) complex which is involved in determining the site of synaptic vesicle fusion. The C-terminus is a PDZ-binding motif that binds directly to RIM (a small G protein Rab-3A effector). The family also contains four coiled-coil domains.


Pssm-ID: 431111 [Multi-domain]  Cd Length: 766  Bit Score: 45.58  E-value: 3.50e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1174 REQLRRKEE---------QYRKEVEVKQQLELSLQTLEMELRTVKsNLNQVVQ--------------------ERNDAQR 1224
Cdd:pfam10174   43 KERALRKEEaarisvlkeQYRVTQEENQHLQLTIQALQDELRAQR-DLNQLLQqdfttspvdgedkfstpeltEENFRRL 121

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1225 QLSREQNARML----------------QDGIL-TNHLSKQKEIEMAQKKMNSENSHSHEEEKdlshknsmlQEEIAMLRL 1287
Cdd:pfam10174  122 QSEHERQAKELfllrktleemelrietQKQTLgARDESIKKLLEMLQSKGLPKKSGEEDWER---------TRRIAEAEM 192

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1288 EIDTIKNQNQEKEKKCFEDLKIVKEKNEDLQ-----KTIKQNEETLTQTISQYNGRLSVLTAENAML--NSKLENEKQSK 1360
Cdd:pfam10174  193 QLGHLEVLLDQKEKENIHLREELHRRNQLQPdpaktKALQTVIEMKDTKISSLERNIRDLEDEVQMLktNGLLHTEDREE 272

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1361 ERLEAEVESYHSRLAAAIHDRDQSETSKRELEL-AFQrardecSRLqDKMNFDVSNLKDNNEILSQQLFKTESKLNSLEI 1439
Cdd:pfam10174  273 EIKQMEVYKSHSKFMKNKIDQLKQELSKKESELlALQ------TKL-ETLTNQNSDCKQHIEVLKESLTAKEQRAAILQT 345

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1440 EFHHTRDALREKTLGLERVQKDLSQTQ----CQMKEMEQKYQNEQVKVNKYIGKQESVEERLSQLQSENMLLR------Q 1509
Cdd:pfam10174  346 EVDALRLRLEEKESFLNKKTKQLQDLTeeksTLAGEIRDLKDMLDVKERKINVLQKKIENLQEQLRDKDKQLAglkervK 425

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1510 QLDDAHNKADNKEKTVINIQDQFHAIVQKLQAESEKQSLLLEERNKELISECNHLKERQYQYENEKAEREVVVRQLQQel 1589
Cdd:pfam10174  426 SLQTDSSNTDTALTTLEEALSEKERIIERLKEQREREDRERLEELESLKKENKDLKEKVSALQPELTEKESSLIDLKE-- 503

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1590 adtlKKQSMSEASLEVTSRYRiNLEDETQDLKKKLGQIRNQLQEAQDRhTEAVRCAEKMQDHKQKLEKDNAKLKVTVKKQ 1669
Cdd:pfam10174  504 ----HASSLASSGLKKDSKLK-SLEIAVEQKKEECSKLENQLKKAHNA-EEAVRTNPEINDRIRLLEQEVARYKEESGKA 577

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1670 MDKIEELQKNLLNANLSEDEKEqlKKLMELKQSLECNLDQEMKKNVELEREITGfknllkMTRKKLNEYENGefsfhgdl 1749
Cdd:pfam10174  578 QAEVERLLGILREVENEKNDKD--KKIAELESLTLRQMKEQNKKVANIKHGQQE------MKKKGAQLLEEA-------- 641

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1750 ktSQFEMDIQINKLKHKIDDLTAELETAGSKC----LHLDTKNQILQ-----------------EELLSMK------TVQ 1802
Cdd:pfam10174  642 --RRREDNLADNSQQLQLEELMGALEKTRQELdatkARLSSTQQSLAekdghltnlraerrkqlEEILEMKqeallaAIS 719

                          730       740       750       760
                   ....*....|....*....|....*....|....*....|..
gi 2462517825 1803 KK------CEKLQKNKKKLEQEVINLRSHIERNMVELGQVKQ 1838
Cdd:pfam10174  720 EKdanialLELSSSKKKKTQEEVMALKREKDRLVHQLKQQTQ 761
PRK10929 PRK10929
putative mechanosensitive channel protein; Provisional
 1119-1345 6.07e-04

putative mechanosensitive channel protein; Provisional


Pssm-ID: 236798 [Multi-domain]  Cd Length: 1109  Bit Score: 45.04  E-value: 6.07e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1119 DKVNVLQRELSETKEIKSQLE----HQKV--EWERELCSLRFSLNQEEEKRRNadtlyekIREQLRRKE-EQyrKEVEVK 1191
Cdd:PRK10929    45 EIVEALQSALNWLEERKGSLErakqYQQVidNFPKLSAELRQQLNNERDEPRS-------VPPNMSTDAlEQ--EILQVS 115

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1192 QQL-ELS--LQTLEMELRTVKSNLNQVVQERNDAQRQLSreQNARMLQdgILTNHLSKQKEIEMAQKKMNSENSHSHEEE 1268
Cdd:PRK10929   116 SQLlEKSrqAQQEQDRAREISDSLSQLPQQQTEARRQLN--EIERRLQ--TLGTPNTPLAQAQLTALQAESAALKALVDE 191

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1269 KDLSHKNSMLQEEIAMLRLEI----------------DTIKNQNQEKEKKCFEDLKIVKEKNEDLQKTI----KQNEEtL 1328
Cdd:PRK10929   192 LELAQLSANNRQELARLRSELakkrsqqldaylqalrNQLNSQRQREAERALESTELLAEQSGDLPKSIvaqfKINRE-L 270

                          250
                   ....*....|....*..
gi 2462517825 1329 TQTISQYNGRLSVLTAE 1345
Cdd:PRK10929   271 SQALNQQAQRMDLIASQ 287
COG5022 COG5022
Myosin heavy chain [General function prediction only];
1115-1741 6.51e-04

Myosin heavy chain [General function prediction only];


Pssm-ID: 227355 [Multi-domain]  Cd Length: 1463  Bit Score: 45.07  E-value: 6.51e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1115 KKMEDKVNVLQRELsETKEIKSQLEHQKVEWERELCSLRFSLNQEEEKRRNA---DTLYEKI---REQLRRKEEQYRKEV 1188
Cdd:COG5022    813 RSYLACIIKLQKTI-KREKKLRETEEVEFSLKAEVLIQKFGRSLKAKKRFSLlkkETIYLQSaqrVELAERQLQELKIDV 891

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1189 EVKQQLELSLQTLEMELRTVKSNLNQVVQERNDAQRQLSREQnARMLQDGILTNHLSKQKEIEMAQKKMNSENSHSHEEE 1268
Cdd:COG5022    892 KSISSLKLVNLELESEIIELKKSLSSDLIENLEFKTELIARL-KKLLNNIDLEEGPSIEYVKLPELNKLHEVESKLKETS 970

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1269 KDLSHKNSMLQEEIAMLRLEIDTIKNQNQEKEKKcfedlkivKEKNEDLQKTIKQNEETltqtisqyNGRLSVLTAENAM 1348
Cdd:COG5022    971 EEYEDLLKKSTILVREGNKANSELKNFKKELAEL--------SKQYGALQESTKQLKEL--------PVEVAELQSASKI 1034

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1349 LNSKLENEKQSKErlEAEVESyhsrlaaaIHDRDQSETSKRELELAFQRARDECSRLQDKMNFDVSNLKDNNEILSQQLF 1428
Cdd:COG5022   1035 ISSESTELSILKP--LQKLKG--------LLLLENNQLQARYKALKLRRENSLLDDKQLYQLESTENLLKTINVKDLEVT 1104

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1429 KTESKLNSLEIEF-----------HHTRDALREKTLGLERVQKDLSQTQCQMKEMEQKYQNEQV---KVNKYIGKQESV- 1493
Cdd:COG5022   1105 NRNLVKPANVLQFivaqmiklnllQEISKFLSQLVNTLEPVFQKLSVLQLELDGLFWEANLEALpspPPFAALSEKRLYq 1184

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1494 ----EERLSQLQSENMLLRQQLD---DAHNKADNKEKTVINIQDQ---FHAIVQKLQAESEKQSLLLEER---NKELISE 1560
Cdd:COG5022   1185 salyDEKSKLSSSEVNDLKNELIalfSKIFSGWPRGDKLKKLISEgwvPTEYSTSLKGFNNLNKKFDTPAsmsNEKLLSL 1264

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1561 CNHLKERQYQYENEKAEREVVVRQLQQELADTLKKQ-SMSEASLEVTSRYRINlEDETQDLKKKLGQIRNQLQEAQDRHT 1639
Cdd:COG5022   1265 LNSIDNLLSSYKLEEEVLPATINSLLQYINVGLFNAlRTKASSLRWKSATEVN-YNSEELDDWCREFEISDVDEELEELI 1343

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1640 EAVRCaekmqdhKQKLEKDNAKLKVTVkkqmdKIEELQKNLLNANLSEDEKEQLKklmelkqslECNLDQEMKKNV---- 1715
Cdd:COG5022   1344 QAVKV-------LQLLKDDLNKLDELL-----DACYSLNPAEIQNLKSRYDPADK---------ENNLPKEILKKIeall 1402

                          650       660
                   ....*....|....*....|....*....
gi 2462517825 1716 ---ELEREITGFKNLLKMTRKKLNEYENG 1741
Cdd:COG5022   1403 ikqELQLSLEGKDETEVHLSEIFSEEKSL 1431
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 1279-1503 7.10e-04

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 44.37  E-value: 7.10e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1279 QEEIAMLRLEIDTIKNQNQEKEKKcfedLKIVKEKNEDLQKTIKQneetLTQTISQYNGRLSVLTAENAMLNSKLENEKQ 1358
Cdd:COG4942     19 ADAAAEAEAELEQLQQEIAELEKE----LAALKKEEKALLKQLAA----LERRIAALARRIRALEQELAALEAELAELEK 90

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1359 SKERLEAEVESYHSRLAAAIHDRDQSETSKRELELAFQRARDECSRLQDKMNFDVSNLKDNNEILSQQLFKTESKLNSLE 1438
Cdd:COG4942     91 EIAELRAELEAQKEELAELLRALYRLGRQPPLALLLSPEDFLDAVRRLQYLKYLAPARREQAEELRADLAELAALRAELE 170

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2462517825 1439 IEFHHTRDALREKTLGLERVQKDLSQTQCQMKEMEQKYQNEQVKVNKYIGKQESVEERLSQLQSE 1503
Cdd:COG4942    171 AERAELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAE 235
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 79-108 7.88e-04

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 38.72  E-value: 7.88e-04
                            10        20        30
                    ....*....|....*....|....*....|
gi 2462517825    79 MNRTALHLACANGHPEVVTLLVDRKCQLNV 108
Cdd:smart00248    1 DGRTPLHLAAENGNLEVVKLLLDKGADINA 30
ClpA COG0542
ATP-dependent Clp protease, ATP-binding subunit ClpA [Posttranslational modification, protein ...
 1400-1567 8.50e-04

ATP-dependent Clp protease, ATP-binding subunit ClpA [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440308 [Multi-domain]  Cd Length: 836  Bit Score: 44.69  E-value: 8.50e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1400 DE-CSRLqdKMNfdvsnlkdnNEILSQQLFKTESKLNSLEIEfhhtRDAL-REKTLG----LERVQKDLSQTQCQMKEME 1473
Cdd:COG0542    396 DEaAARV--RME---------IDSKPEELDELERRLEQLEIE----KEALkKEQDEAsferLAELRDELAELEEELEALK 460

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1474 QKYQNEQVKVNKYIGKQESVEERLSQLQSenmlLRQQLDDAHNKADNKEKTVINI--QDQFHAIV--------QKLQaES 1543
Cdd:COG0542    461 ARWEAEKELIEEIQELKEELEQRYGKIPE----LEKELAELEEELAELAPLLREEvtEEDIAEVVsrwtgipvGKLL-EG 535

                          170       180
                   ....*....|....*....|....*
gi 2462517825 1544 EKQSLL-LEErnkelisecnHLKER 1567
Cdd:COG0542    536 EREKLLnLEE----------ELHER 550
Rabaptin pfam03528
Rabaptin;
1491-1711 8.59e-04

Rabaptin;


Pssm-ID: 367545 [Multi-domain]  Cd Length: 486  Bit Score: 44.33  E-value: 8.59e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1491 ESVEERLSQLQSEN---MLLRQQLDDAHNKADNKektviniqdqFHAIVQKLQAESEKQSLLLEERNKELISECNHLKER 1567
Cdd:pfam03528    4 EDLQQRVAELEKENaefYRLKQQLEAEFNQKRAK----------FKELYLAKEEDLKRQNAVLQEAQVELDALQNQLALA 73

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1568 QYQYENEKAeREVVVRQLQQELADTLKKQ----------SMSEASLEVTSRYRINLEDE-------TQDLKKKLGQIRNQ 1630
Cdd:pfam03528   74 RAEMENIKA-VATVSENTKQEAIDEVKSQwqeevaslqaIMKETVREYEVQFHRRLEQEraqwnqyRESAEREIADLRRR 152

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1631 LQEAQDRhteavrcaEKMQDHKQKLEKDNAKLKVTVKKQMDKIEELQKNLLNAnlsEDEKEQLK--KLMELKQSLE---- 1704
Cdd:pfam03528  153 LSEGQEE--------ENLEDEMKKAQEDAEKLRSVVMPMEKEIAALKAKLTEA---EDKIKELEasKMKELNHYLEaeks 221


                   ....*..
gi 2462517825 1705 CNLDQEM 1711
Cdd:pfam03528  222 CRTDLEM 228
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 80-108 9.42e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 38.39  E-value: 9.42e-04
                           10        20
                   ....*....|....*....|....*....
gi 2462517825   80 NRTALHLACANGHPEVVTLLVDRKCQLNV 108
Cdd:pfam13606    2 GNTPLHLAARNGRLEIVKLLLENGADINA 30
PRK11281 PRK11281
mechanosensitive channel MscK;
1113-1471 9.63e-04

mechanosensitive channel MscK;


Pssm-ID: 236892 [Multi-domain]  Cd Length: 1113  Bit Score: 44.52  E-value: 9.63e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1113 KIKKMEDKVNVLQRELSETKEIKSQLEHQKveweRELCSLRFSLNQEEEKRRNADTLYEKIREQLrrkeeqyrkEVEVKQ 1192
Cdd:PRK11281    50 KQKLLEAEDKLVQQDLEQTLALLDKIDRQK----EETEQLKQQLAQAPAKLRQAQAELEALKDDN---------DEETRE 116

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1193 QLE-LSLQTLEmelrtvkSNLNQVVQERNDAQRQLSrEQNARMlqdgiltnhLSKQKEIEMAQKKMNSENSHSHEEEKDL 1271
Cdd:PRK11281   117 TLStLSLRQLE-------SRLAQTLDQLQNAQNDLA-EYNSQL---------VSLQTQPERAQAALYANSQRLQQIRNLL 179

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1272 SH----KNSMLQEEIAMLRLEIDTIKNQNqekekkcfedlkivkekneDLQKTIKQNEETLTQTisqYNGRLSVLTAENA 1347
Cdd:PRK11281   180 KGgkvgGKALRPSQRVLLQAEQALLNAQN-------------------DLQRKSLEGNTQLQDL---LQKQRDYLTARIQ 237

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1348 mlnsklenekqskeRLEAEVESyhsrLAAAIHDR--DQSETSKRELElafqrARDECSRLQDkmNFDVSNLKDNNEILSQ 1425
Cdd:PRK11281   238 --------------RLEHQLQL----LQEAINSKrlTLSEKTVQEAQ-----SQDEAARIQA--NPLVAQELEINLQLSQ 292

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|....*.
gi 2462517825 1426 QLFKTESKLNSLeiefhhTRDALREKTLgLERvqkdLSQTQCQMKE 1471
Cdd:PRK11281   293 RLLKATEKLNTL------TQQNLRVKNW-LDR----LTQSERNIKE 327
PRK04778 PRK04778
septation ring formation regulator EzrA; Provisional
 1621-1930 1.02e-03

septation ring formation regulator EzrA; Provisional


Pssm-ID: 179877 [Multi-domain]  Cd Length: 569  Bit Score: 44.06  E-value: 1.02e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1621 KKKLGQIRNQLQEAQDRHteavrcaEKMQDHKQKLEKDNAKLKVTVKKQMDKIEELQKNLLNANLS------------ED 1688
Cdd:PRK04778   104 KHEINEIESLLDLIEEDI-------EQILEELQELLESEEKNREEVEQLKDLYRELRKSLLANRFSfgpaldelekqlEN 176

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1689 EKEQLKKLMELKQS---------LEcNLDQEMKknvELEREITGFKNLLKMTRKK----LNEYENGefsfHGDLKTS--- 1752
Cdd:PRK04778   177 LEEEFSQFVELTESgdyveareiLD-QLEEELA---ALEQIMEEIPELLKELQTElpdqLQELKAG----YRELVEEgyh 248

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1753 --QFEMDIQINKLKHKIDDLTAELETagskcLHLD---TKNQILQEELLSM-----------KTVQKKCEKLQKNKKKLE 1816
Cdd:PRK04778   249 ldHLDIEKEIQDLKEQIDENLALLEE-----LDLDeaeEKNEEIQERIDQLydilerevkarKYVEKNSDTLPDFLEHAK 323

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1817 QEVINLRSHIER-------NMVELGQVKQYKQEIE--ERARQEIAEKLKEvnlflQAQAAS--QENLEQfrennfasmks 1885
Cdd:PRK04778   324 EQNKELKEEIDRvkqsytlNESELESVRQLEKQLEslEKQYDEITERIAE-----QEIAYSelQEELEE----------- 387

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|....*
gi 2462517825 1886 qmelrikdLESELSKIKTSQEDFNktelEKYKQLYLEELKVRKSL 1930
Cdd:PRK04778   388 --------ILKQLEEIEKEQEKLS----EMLQGLRKDELEAREKL 420
Crescentin pfam19220
Crescentin protein; This entry represents a bacterial equivalent to Intermediate Filament ...
 1263-1581 1.09e-03

Crescentin protein; This entry represents a bacterial equivalent to Intermediate Filament proteins, named crescentin, whose cytoskeletal function is required for the vibrioid and helical shapes of Caulobacter crescentus. Without crescentin, the cells adopt a straight-rod morphology. Crescentin has characteriztic features of IF proteins including the ability to assemble into filaments in vitro without energy or cofactor requirements. In vivo, crescentin forms a helical structure that colocalizes with the inner cell curvatures beneath the cytoplasmic membrane.


Pssm-ID: 437057 [Multi-domain]  Cd Length: 401  Bit Score: 43.90  E-value: 1.09e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1263 HSHEEEKDLSHKNSMLQEEIAMLRLEIDTIKNQNQEKEKKCFEDLKivkeKNEDLQKTIKQNEETltqtISQYNGRLSVL 1342
Cdd:pfam19220   45 QAKSRLLELEALLAQERAAYGKLRRELAGLTRRLSAAEGELEELVA----RLAKLEAALREAEAA----KEELRIELRDK 116

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1343 TAENAMLNSKLENEKQSKERLEAEVESYHSRLAAAIHDRDQSETSKRELELAFQRARDECSRLQ---DKMNFDVSNLKDN 1419
Cdd:pfam19220  117 TAQAEALERQLAAETEQNRALEEENKALREEAQAAEKALQRAEGELATARERLALLEQENRRLQalsEEQAAELAELTRR 196

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1420 NEILSQQLFKTESKLNSLEIEFHHTRdALREK----------TLGLER----------------VQKDLSQTQCQMKEME 1473
Cdd:pfam19220  197 LAELETQLDATRARLRALEGQLAAEQ-AERERaeaqleeaveAHRAERaslrmklealtaraaaTEQLLAEARNQLRDRD 275

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1474 QKYQNEQVKVNKYIGKQESVEERLSQLQSENMLLRQQLDDAH-------------NKA--------DNKEKTVINIQDQf 1532
Cdd:pfam19220  276 EAIRAAERRLKEASIERDTLERRLAGLEADLERRTQQFQEMQraraeleeraemlTKAlaakdaalERAEERIASLSDR- 354

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|....*....
gi 2462517825 1533 haiVQKLQAESEKQSLLLEERNKELISEcnhlkerqyqYENEKAEREVV 1581
Cdd:pfam19220  355 ---IAELTKRFEVERAALEQANRRLKEE----------LQRERAERALA 390
235kDa-fam TIGR01612
reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in ...
 1026-1780 1.12e-03

reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in plasmodium species alternately annotated as reticulocyte binding protein, 235-kDa family protein and rhoptry protein. Rhoptry protein is localized on the cell surface and is extremely large (although apparently lacking in repeat structure) and is important for the process of invasion of the RBCs by the parasite. These proteins are found in P. falciparum, P. vivax and P. yoelii.


Pssm-ID: 130673 [Multi-domain]  Cd Length: 2757  Bit Score: 44.27  E-value: 1.12e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1026 KKTSNEKNKVKNQIQSMDDVDDLTQSSETASedcelphssyknfmllieqlGMECKDSVSLLKIQdaalscerllelkkn 1105
Cdd:TIGR01612 1139 KKSENYIDEIKAQINDLEDVADKAISNDDPE--------------------EIEKKIENIVTKID--------------- 1183

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1106 hcelltvKIKKMEDKVNVLQRELSETKEIKSQLEHQK---VEWERELCSLrFSLNQEEEKRRNADTL-----YEKIREQL 1177
Cdd:TIGR01612 1184 -------KKKNIYDEIKKLLNEIAEIEKDKTSLEEVKginLSYGKNLGKL-FLEKIDEEKKKSEHMIkameaYIEDLDEI 1255

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1178 RRKEEQYRKEVEVKQQLELSLQTLEMELRTVKSnlNQVVQERNDAQRQLSREQNARMLQDgiltnhLSKQKEIEMAQKKM 1257
Cdd:TIGR01612 1256 KEKSPEIENEMGIEMDIKAEMETFNISHDDDKD--HHIISKKHDENISDIREKSLKIIED------FSEESDINDIKKEL 1327

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1258 NSENSHSHEEEKDLSHKNSMLQEEIAMLRL-EIDTIKNQNQEKEKKCFEDLKIVK---EKNEDLQKTIKQNE--ETLTQT 1331
Cdd:TIGR01612 1328 QKNLLDAQKHNSDINLYLNEIANIYNILKLnKIKKIIDEVKEYTKEIEENNKNIKdelDKSEKLIKKIKDDInlEECKSK 1407

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1332 ISQyngrlsvlTAENAMLNSKLENEKQSKERLEAEVESYHSRLAAAIHDRDQSETSKRELELAFQRA----RDECSRLQD 1407
Cdd:TIGR01612 1408 IES--------TLDDKDIDECIKKIKELKNHILSEESNIDTYFKNADENNENVLLLFKNIEMADNKSqhilKIKKDNATN 1479

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1408 KMNFDVSNLKDNNEilSQQLFKTESKLNSLEIEfhhtrdalREKTLgLERVQKDLSQTQCQMKEMEQKYQNEQVKV---- 1483
Cdd:TIGR01612 1480 DHDFNINELKEHID--KSKGCKDEADKNAKAIE--------KNKEL-FEQYKKDVTELLNKYSALAIKNKFAKTKKdsei 1548

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1484 ---------NKYIGKQESVEERLSQLQSENMllrqQLDDAHNKADNKEKTVINIQdqfhaivqkLQAESEKQSLLLEERN 1554
Cdd:TIGR01612 1549 iikeikdahKKFILEAEKSEQKIKEIKKEKF----RIEDDAAKNDKSNKAAIDIQ---------LSLENFENKFLKISDI 1615

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1555 KELISECnhLKERQyqyENEKAEREVVVRQLQQELADTLKKQSMSEASLEVTSRYRINLED---ETQDLKKKLGQIRNQL 1631
Cdd:TIGR01612 1616 KKKINDC--LKETE---SIEKKISSFSIDSQDTELKENGDNLNSLQEFLESLKDQKKNIEDkkkELDELDSEIEKIEIDV 1690

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1632 QEAQDRHTEAV--RCAEKMQDHKQKLEKDNAKLKVTVKKQMDKI--EELQKNLLNANLSEDEKEQ---LKKLMELKQSLE 1704
Cdd:TIGR01612 1691 DQHKKNYEIGIieKIKEIAIANKEEIESIKELIEPTIENLISSFntNDLEGIDPNEKLEEYNTEIgdiYEEFIELYNIIA 1770

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1705 CNLDQEMKKNVELER----EITGFKNLLKM--TRKKLNEYENgefsfhgDLKTSQFemDIQINKLKHKIDDLTAELETAG 1778
Cdd:TIGR01612 1771 GCLETVSKEPITYDEikntRINAQNEFLKIieIEKKSKSYLD-------DIEAKEF--DRIINHFKKKLDHVNDKFTKEY 1841


                   ..
gi 2462517825 1779 SK 1780
Cdd:TIGR01612 1842 SK 1843
Mitofilin pfam09731
Mitochondrial inner membrane protein; Mitofilin controls mitochondrial cristae morphology. ...
 1350-1696 1.24e-03

Mitochondrial inner membrane protein; Mitofilin controls mitochondrial cristae morphology. Mitofilin is enriched in the narrow space between the inner boundary and the outer membranes, where it forms a homotypic interaction and assembles into a large multimeric protein complex. The first 78 amino acids contain a typical amino-terminal-cleavable mitochondrial presequence rich in positive-charged and hydroxylated residues and a membrane anchor domain. In addition, it has three centrally located coiled coil domains.


Pssm-ID: 430783 [Multi-domain]  Cd Length: 618  Bit Score: 43.98  E-value: 1.24e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1350 NSKLENEKQSKERLEAEVESYHSRLAAAIHDRDQSETSKRELELAFQRARDECSRLQDKMnfdVSNLKDNNEILSQQLFK 1429
Cdd:pfam09731  121 KSEQEKEKALEEVLKEAISKAESATAVAKEAKDDAIQAVKAHTDSLKEASDTAEISREKA---TDSALQKAEALAEKLKE 197

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1430 TESKLNSLEIEfhhtrdALREKTLGLERVQKDLSQTQCQMKEMEQKYQNEQVKVNKYigkQESVEErlsqlqsENMLLRQ 1509
Cdd:pfam09731  198 VINLAKQSEEE------AAPPLLDAAPETPPKLPEHLDNVEEKVEKAQSLAKLVDQY---KELVAS-------ERIVFQQ 261

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1510 QLDDAHN------KADNKEKTviniqDQFHAIVQKLQAEsekqsllLEERNKELIsecnHLKERqyqyENEKAEREVVVR 1583
Cdd:pfam09731  262 ELVSIFPdiipvlKEDNLLSN-----DDLNSLIAHAHRE-------IDQLSKKLA----ELKKR----EEKHIERALEKQ 321

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1584 QLQQELADTLKKQSMSEASLEVTSRYRINLEDETQDLKKKL-GQIRNQLQEAQDRHTEAVRCAEK----------MQDHK 1652
Cdd:pfam09731  322 KEELDKLAEELSARLEEVRAADEAQLRLEFEREREEIRESYeEKLRTELERQAEAHEEHLKDVLVeqeielqrefLQDIK 401

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|....
gi 2462517825 1653 QKLEKDNAKLKVTVKKQMDKIEELQKNLLNANLSEDEKEQLKKL 1696
Cdd:pfam09731  402 EKVEEERAGRLLKLNELLANLKGLEKATSSHSEVEDENRKAQQL 445
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
1265-1859 1.28e-03

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 44.14  E-value: 1.28e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1265 HEEEKDLSHKNSMLQEEIAMLRLEIDTIK-NQNQEKEKKCFEDLKIVKEKNEDLQKTIKQNEETLTQTISQYNG----RL 1339
Cdd:COG4913    261 AERYAAARERLAELEYLRAALRLWFAQRRlELLEAELEELRAELARLEAELERLEARLDALREELDELEAQIRGnggdRL 340

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1340 SVLTAEnamlnskLENEKQSKERLEAEVESYHSRLAAAIHDRDQSETSKRELELAFQRARDECSRLQDKMNFDVSNLKDN 1419
Cdd:COG4913    341 EQLERE-------IERLERELEERERRRARLEALLAALGLPLPASAEEFAALRAEAAALLEALEEELEALEEALAEAEAA 413

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1420 NEILSQQLFKTESKLNSLE-------IEFHHTRDALREKtLGLERVQ----KDLsqtqCQMKEMEQKYQNeqvKVNKYIG 1488
Cdd:COG4913    414 LRDLRRELRELEAEIASLErrksnipARLLALRDALAEA-LGLDEAElpfvGEL----IEVRPEEERWRG---AIERVLG 485

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1489 KQesveeRLSqlqsenMLLRQQLDDAHNKA--DNKEKTVINIQDQFHAIVQKLQAESEKQSLL--LEERNKELISECNHL 1564
Cdd:COG4913    486 GF-----ALT------LLVPPEHYAAALRWvnRLHLRGRLVYERVRTGLPDPERPRLDPDSLAgkLDFKPHPFRAWLEAE 554

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1565 KERQYQYEneKAEREvvvrqlqQELADTlkKQSMSEASL--EVTSRYRINLEDET-------QDLKKKLGQIRNQLQEAQ 1635
Cdd:COG4913    555 LGRRFDYV--CVDSP-------EELRRH--PRAITRAGQvkGNGTRHEKDDRRRIrsryvlgFDNRAKLAALEAELAELE 623

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1636 DRHTEAVRCAEKMQDHKQKLEKDNAKLKVTVKKQMD---------KIEELQKNLLNANLSEDE----KEQLKKLMELKQS 1702
Cdd:COG4913    624 EELAEAEERLEALEAELDALQERREALQRLAEYSWDeidvasaerEIAELEAELERLDASSDDlaalEEQLEELEAELEE 703

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1703 LECNLDQEMKKNVELEREITGFKNLLKMTRKKLNEYENGEFSFH--------GDLKTSQFEMDIQiNKLKHKIDDLTAEL 1774
Cdd:COG4913    704 LEEELDELKGEIGRLEKELEQAEEELDELQDRLEAAEDLARLELralleerfAAALGDAVERELR-ENLEERIDALRARL 782

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1775 ETAGSKCL----------HLDTKNqiLQEELLSMKTVQKKCEKLQKNK-KKLEQEvinLRSHIERNMVElgQVKQYKQEI 1843
Cdd:COG4913    783 NRAEEELEramrafnrewPAETAD--LDADLESLPEYLALLDRLEEDGlPEYEER---FKELLNENSIE--FVADLLSKL 855

                          650
                   ....*....|....*.
gi 2462517825 1844 EeRARQEIAEKLKEVN 1859
Cdd:COG4913    856 R-RAIREIKERIDPLN 870
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 1423-1641 1.32e-03

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 43.28  E-value: 1.32e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1423 LSQQLFKTESKLNSLEIEFhhtrDALREKtlgLERVQKDLSQTQCQMKEMEQKYQNEQVKVNKyigKQESVEERLSQLQS 1502
Cdd:COG3883     28 LQAELEAAQAELDALQAEL----EELNEE---YNELQAELEALQAEIDKLQAEIAEAEAEIEE---RREELGERARALYR 97

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1503 E-------NMLLRQQ-LDDAHNKADNKEKtvinIQDQFHAIV---QKLQAESEKQSLLLEERNKELISECNHLKERQYQY 1571
Cdd:COG3883     98 SggsvsylDVLLGSEsFSDFLDRLSALSK----IADADADLLeelKADKAELEAKKAELEAKLAELEALKAELEAAKAEL 173

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1572 ENEKAEREVVVRQLQQELADTLKKQSMSEASLEVTSRYRINLEDETQDLKKKLGQIRNQLQEAQDRHTEA 1641
Cdd:COG3883    174 EAQQAEQEALLAQLSAEEAAAEAQLAELEAELAAAEAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA 243
PHA02736 PHA02736
Viral ankyrin protein; Provisional
 75-203 1.37e-03

Viral ankyrin protein; Provisional


Pssm-ID: 165103 [Multi-domain]  Cd Length: 154  Bit Score: 41.40  E-value: 1.37e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825   75 DRDKMNRTALHLACANGhpEVVTLLVDRkcqlNVCDNENRTALMK----AVQC-----------QEEKCaTILLEHGADP 139
Cdd:PHA02736    12 EPDIEGENILHYLCRNG--GVTDLLAFK----NAISDENRYLVLEynrhGKQCvhivsnpdkadPQEKL-KLLMEWGADI 84

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462517825  140 NLAD-VHGNTALHYAVYNEDISVATKLLLY-DANIEAKNKDDLTPLLLAVSGKKQQMVEFLIKKKA 203
Cdd:PHA02736    85 NGKErVFGNTPLHIAVYTQNYELATWLCNQpGVNMEILNYAFKTPYYVACERHDAKMMNILRAKGA 150
SPEC cd00176
Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members ...
 1543-1740 1.40e-03

Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; the repeats are independent folding units; tandem repeats are found in differing numbers and arrange in an antiparallel manner to form dimers; the repeats are defined by a characteristic tryptophan (W) residue in helix A and a leucine (L) at the carboxyl end of helix C and separated by a linker of 5 residues; two copies of the repeat are present here


Pssm-ID: 238103 [Multi-domain]  Cd Length: 213  Bit Score: 42.43  E-value: 1.40e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1543 SEKQSLLLEERNKELISECNHLKERQYQYENEKAEREVVVRQLQQeLADTLkKQSMSEASLEVTSRYRiNLEDETQDLKK 1622
Cdd:cd00176     17 SEKEELLSSTDYGDDLESVEALLKKHEALEAELAAHEERVEALNE-LGEQL-IEEGHPDAEEIQERLE-ELNQRWEELRE 93

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1623 KLGQIRNQLQEAQDRHT---EAVRCAEKMQDHKQKLEK-DNAKLKVTVKKQMDKIEELQKNLlnanlsEDEKEQLKKLME 1698
Cdd:cd00176     94 LAEERRQRLEEALDLQQffrDADDLEQWLEEKEAALASeDLGKDLESVEELLKKHKELEEEL------EAHEPRLKSLNE 167

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....
gi 2462517825 1699 LKQSL--ECNLDQEMKKNVELEREITGFKNLLKMTRKKLNEYEN 1740
Cdd:cd00176    168 LAEELleEGHPDADEEIEEKLEELNERWEELLELAEERQKKLEE 211
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 145-177 1.44e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 38.04  E-value: 1.44e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 2462517825  145 HGNTALHYAVYNE-DISVATKLLLYDANIEAKNK 177
Cdd:pfam00023    1 DGNTPLHLAAGRRgNLEIVKLLLSKGADVNARDK 34
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 79-215 1.75e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 43.06  E-value: 1.75e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825   79 MNRTALHLACANGHPEVVTLLVDRKCQLNVCDNENRTALMKAVQCQEEKCATILLEHGADPNLADVHGNTALHYAVYNED 158
Cdd:PHA02875     1 MDQVALCDAILFGELDIARRLLDIGINPNFEIYDGISPIKLAMKFRDSEAIKLLMKHGAIPDVKYPDIESELHDAVEEGD 80

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825  159 ISVATKLLLYDANI-EAKNKDDLTPLLLAVSGKKQQMVEFLIKKKA--NVNAVDKLESSH 215
Cdd:PHA02875    81 VKAVEELLDLGKFAdDVFYKDGMTPLHLATILKKLDIMKLLIARGAdpDIPNTDKFSPLH 140
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
1403-1700 1.78e-03

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 42.97  E-value: 1.78e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1403 SRLQDKMNFDVSNLKDNNEILSQQLFKTESKLNSLEIEFHHTRDALREKTLGLERVQKDLSQTQCQMKEMEQKYQNEQVK 1482
Cdd:COG4372     30 SEQLRKALFELDKLQEELEQLREELEQAREELEQLEEELEQARSELEQLEEELEELNEQLQAAQAELAQAQEELESLQEE 109

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1483 VNKYIGKQESVEERLSQLQSENMLLRQQLDDAHNKADNKEKTVINIQDQFHAIVQKLQAESEKQSLLLEERNKELISECN 1562
Cdd:COG4372    110 AEELQEELEELQKERQDLEQQRKQLEAQIAELQSEIAEREEELKELEEQLESLQEELAALEQELQALSEAEAEQALDELL 189

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1563 HLKERQYQYENEKAEREVVVRQLQQELADTLKKQSMSEASLEVTSRYRINLEDETQDLKKKLGQIRNQLQEAQDRHTEAV 1642
Cdd:COG4372    190 KEANRNAEKEEELAEAEKLIESLPRELAEELLEAKDSLEAKLGLALSALLDALELEEDKEELLEEVILKEIEELELAILV 269

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 2462517825 1643 RCAEKMQDHKQKLEKDNAKLKVTVKKQMDKIEELQKNLLNANLSEDEKEQLKKLMELK 1700
Cdd:COG4372    270 EKDTEEEELEIAALELEALEEAALELKLLALLLNLAALSLIGALEDALLAALLELAKK 327
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 178-210 1.98e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 37.65  E-value: 1.98e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 2462517825  178 DDLTPLLLAV-SGKKQQMVEFLIKKKANVNAVDK 210
Cdd:pfam00023    1 DGNTPLHLAAgRRGNLEIVKLLLSKGADVNARDK 34
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
1152-1363 2.49e-03

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 43.08  E-value: 2.49e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1152 LRFSLNQEEEKRRNADTLYEK----IREQLRRKE---EQYRKE-------------VEVKQQLELSLQTLEMELRTVKSN 1211
Cdd:COG3206    162 LEQNLELRREEARKALEFLEEqlpeLRKELEEAEaalEEFRQKnglvdlseeakllLQQLSELESQLAEARAELAEAEAR 241

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1212 LNQVvqernDAQRQLSREQNARMLQDGILTNHLSKQKEIEMAQKKMNSENSHSHeeekdlshknsmlqEEIAMLRLEIDT 1291
Cdd:COG3206    242 LAAL-----RAQLGSGPDALPELLQSPVIQQLRAQLAELEAELAELSARYTPNH--------------PDVIALRAQIAA 302

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462517825 1292 IKNQNQEKEKKCFEDLKIVKEknedlqkTIKQNEETLTQTISQYNGRLSVLTAENAMLNSkLENEKQSKERL 1363
Cdd:COG3206    303 LRAQLQQEAQRILASLEAELE-------ALQAREASLQAQLAQLEARLAELPELEAELRR-LEREVEVAREL 366
CALCOCO1 pfam07888
Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are ...
 1586-1837 2.73e-03

Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are similar to the coiled-coil transcriptional coactivator protein coexpressed by Mus musculus (CoCoA/CALCOCO1). This protein binds to a highly conserved N-terminal domain of p160 coactivators, such as GRIP1, and thus enhances transcriptional activation by a number of nuclear receptors. CALCOCO1 has a central coiled-coil region with three leucine zipper motifs, which is required for its interaction with GRIP1 and may regulate the autonomous transcriptional activation activity of the C-terminal region.


Pssm-ID: 462303 [Multi-domain]  Cd Length: 488  Bit Score: 42.57  E-value: 2.73e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1586 QQELADTLKKQSMS----EASLEVTSRYRINLEDETQDLKKKLGQIRNQLQEAQDRHTEAVRCAEKMQDHKQKLEKDNAK 1661
Cdd:pfam07888   40 LQERAELLQAQEAAnrqrEKEKERYKRDREQWERQRRELESRVAELKEELRQSREKHEELEEKYKELSASSEELSEEKDA 119

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1662 LKVTVKKQMDKIEELQKNLlnANLSEDEKEQLKKLMELKQSLECNLDQemKKNVELEREitGFKNLLKMTRKKLNEYeNG 1741
Cdd:pfam07888  120 LLAQRAAHEARIRELEEDI--KTLTQRVLERETELERMKERAKKAGAQ--RKEEEAERK--QLQAKLQQTEEELRSL-SK 192

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1742 EFSfhgDLKTSQFEMDIQINKLKHKIDDLTAELETAGSKclhlDTKNQILQEEllsMKTVQKKCEKLQKNKKKLEQEVIN 1821
Cdd:pfam07888  193 EFQ---ELRNSLAQRDTQVLQLQDTITTLTQKLTTAHRK----EAENEALLEE---LRSLQERLNASERKVEGLGEELSS 262

                          250
                   ....*....|....*.
gi 2462517825 1822 LRSHIERNMVELGQVK 1837
Cdd:pfam07888  263 MAAQRDRTQAELHQAR 278
235kDa-fam TIGR01612
reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in ...
 1160-1905 3.04e-03

reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in plasmodium species alternately annotated as reticulocyte binding protein, 235-kDa family protein and rhoptry protein. Rhoptry protein is localized on the cell surface and is extremely large (although apparently lacking in repeat structure) and is important for the process of invasion of the RBCs by the parasite. These proteins are found in P. falciparum, P. vivax and P. yoelii.


Pssm-ID: 130673 [Multi-domain]  Cd Length: 2757  Bit Score: 43.12  E-value: 3.04e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1160 EEKRRNADTLYEKIREQLRRKEEQYRKEVEVKQQlELSLQTLEMELRT---VKSNLNQVVQERNDAQRQLSREQNARMLQ 1236
Cdd:TIGR01612  699 DDLKSKIDKEYDKIQNMETATVELHLSNIENKKN-ELLDIIVEIKKHIhgeINKDLNKILEDFKNKEKELSNKINDYAKE 777

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1237 DGILTNHLSKQKEIEmaqkkmnsenshsheeekdlSHKNSmlqeeiamlRLEIDTIKNqnqekekkcfEDLKIVKEKNED 1316
Cdd:TIGR01612  778 KDELNKYKSKISEIK--------------------NHYND---------QINIDNIKD----------EDAKQNYDKSKE 818

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1317 LQKTIKQNEETLTQTISQY-NGRLSVLTAENAMLNskLENekQSKERLEAEVESYhsrlaAAIHDRDQSETSKRELELAF 1395
Cdd:TIGR01612  819 YIKTISIKEDEIFKIINEMkFMKDDFLNKVDKFIN--FEN--NCKEKIDSEHEQF-----AELTNKIKAEISDDKLNDYE 889

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1396 QRARDECSRLQDKMNF------DVSNLKDNNEIL------SQQLFKTESKLNSLEIEFHHTRDALREKTLgLERVQKDLS 1463
Cdd:TIGR01612  890 KKFNDSKSLINEINKSieeeyqNINTLKKVDEYIkicentKESIEKFHNKQNILKEILNKNIDTIKESNL-IEKSYKDKF 968

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1464 QTQCQMKEMEQKYQNEQVKVNKYIGKQESVEERLSQLQS------ENMLLRQ------QLDDAHNKADNKEKTVINIQDQ 1531
Cdd:TIGR01612  969 DNTLIDKINELDKAFKDASLNDYEAKNNELIKYFNDLKAnlgknkENMLYHQfdekekATNDIEQKIEDANKNIPNIEIA 1048

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1532 FHAIVQKLQAESEKQ-SLLLEERNKELISEC-------NHLKERQYQYENEKAEREVVVRqlqqeLADTLKKQSMSEASL 1603
Cdd:TIGR01612 1049 IHTSIYNIIDEIEKEiGKNIELLNKEILEEAeinitnfNEIKEKLKHYNFDDFGKEENIK-----YADEINKIKDDIKNL 1123

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1604 EVTSRYRINledETQDLKKKLGQIRNQLQeAQDRHTEAVRCAEKMQDHKQKLEKDNAKLKVTVKKQMDKIEELQKNLLNA 1683
Cdd:TIGR01612 1124 DQKIDHHIK---ALEEIKKKSENYIDEIK-AQINDLEDVADKAISNDDPEEIEKKIENIVTKIDKKKNIYDEIKKLLNEI 1199

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1684 NLSEDEKEQLKKLMELKQSLECNL--------DQEMKKNVELEREITGFKNLLKMTRKKLNEYENgEFSFHGDLKTSQFE 1755
Cdd:TIGR01612 1200 AEIEKDKTSLEEVKGINLSYGKNLgklflekiDEEKKKSEHMIKAMEAYIEDLDEIKEKSPEIEN-EMGIEMDIKAEMET 1278

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1756 MDIQINKLK--HKIDDLTAE-LETAGSKCLHLDTKNQILQEELLSMKTVQKKCEKLQKNKKKLEQ---EVINLRSHIERN 1829
Cdd:TIGR01612 1279 FNISHDDDKdhHIISKKHDEnISDIREKSLKIIEDFSEESDINDIKKELQKNLLDAQKHNSDINLylnEIANIYNILKLN 1358

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1830 MVE--LGQVKQYKQEIEERARQEIAEKLKevnlflqaqaaSQENLEQFREN-NFASMKSQMELRI--KDLESELSKIKTS 1904
Cdd:TIGR01612 1359 KIKkiIDEVKEYTKEIEENNKNIKDELDK-----------SEKLIKKIKDDiNLEECKSKIESTLddKDIDECIKKIKEL 1427


                   .
gi 2462517825 1905 Q 1905
Cdd:TIGR01612 1428 K 1428
CEP63 pfam17045
Centrosomal protein of 63 kDa; CEP63 is a family of eukaryotic proteins involved in centriole ...
 1127-1407 3.31e-03

Centrosomal protein of 63 kDa; CEP63 is a family of eukaryotic proteins involved in centriole activity.


Pssm-ID: 465338 [Multi-domain]  Cd Length: 264  Bit Score: 41.73  E-value: 3.31e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1127 ELSE-TKEIKSQLEHQKVEWERELCSLRFSLNQEEEKRRNAdtlyekiREQLRRKEeqyrKEVEVKQQLELSLQTLEMEL 1205
Cdd:pfam17045    7 ELQElMKQIDIMVAHKKSEWEGQTRALETRLDIREEELLSA-------RNTLERKH----KEIGLLRQQLEELEKGKQEL 75

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1206 rTVKSNlnqvvQERNDAQRQLSReqnarmlqdgiLTNHLSKqkeIEMAQKKMNSENSHSHEEEKDLSHKNSMLQEEIAML 1285
Cdd:pfam17045   76 -VAKYE-----QQLQKLQEELSK-----------LKRSYEK---LQRKQLKEAREEAKSREEDRSELSRLNGKLEEFRQK 135

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1286 RLEIDTIKNQNQEKEKKCFEDLKIVKEKNEDLQKTIKQneetltqtiSQYNGRLSVLTA---ENAMLNSKLENEKQSKER 1362
Cdd:pfam17045  136 SLEWEQQRLQYQQQVASLEAQRKALAEQSSLIQSAAYQ---------VQLEGRKQCLEAsqsEIQRLRSKLERAQDSLCA 206

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....*
gi 2462517825 1363 LEAEVESYHSRLAAAIHDRDQSETSKRELELAFQRARDECSRLQD 1407
Cdd:pfam17045  207 QELELERLRMRVSELGDSNRKLLEEQQRLLEELRMSQRQLQVLQN 251
mukB PRK04863
chromosome partition protein MukB;
1108-1821 3.66e-03

chromosome partition protein MukB;


Pssm-ID: 235316 [Multi-domain]  Cd Length: 1486  Bit Score: 42.64  E-value: 3.66e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1108 ELLTVKIKKMEDKVNVLQRELSETKEIKSQLEhqkvEWERELCSLRFSLNQEEEKrrnadtlyEKIREQLRRKEEQyRKE 1187
Cdd:PRK04863   445 EEFQAKEQEATEELLSLEQKLSVAQAAHSQFE----QAYQLVRKIAGEVSRSEAW--------DVARELLRRLREQ-RHL 511

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1188 VEVKQQLELSLQTLEMELRtvksNLNQVVQERNDAQRQLSR-EQNARMLQDgiltnhlsKQKEIEMAQKKMNSENSHSHE 1266
Cdd:PRK04863   512 AEQLQQLRMRLSELEQRLR----QQQRAERLLAEFCKRLGKnLDDEDELEQ--------LQEELEARLESLSESVSEARE 579

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1267 EEKDLSHKNSMLQEEIAMLR------LEIDTIKNQNQEKEKKCFEDLKIVKEKNEDLQ---KTIKQNEETLTQTISQYNG 1337
Cdd:PRK04863   580 RRMALRQQLEQLQARIQRLAarapawLAAQDALARLREQSGEEFEDSQDVTEYMQQLLereRELTVERDELAARKQALDE 659

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1338 RLSVLTAENAmlnSKLENEKQSKERLEAEVES------------YHSRL----AAAIHDRDQSeTSKRELElafqrARDE 1401
Cdd:PRK04863   660 EIERLSQPGG---SEDPRLNALAERFGGVLLSeiyddvsledapYFSALygpaRHAIVVPDLS-DAAEQLA-----GLED 730

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1402 CSRLQDKMNFDVSNLkDNNEILSQQLFKTES-KLNslEIEFHHTR--------DALREKTLGLERVQKDLSQTQCQMKEM 1472
Cdd:PRK04863   731 CPEDLYLIEGDPDSF-DDSVFSVEELEKAVVvKIA--DRQWRYSRfpevplfgRAAREKRIEQLRAEREELAERYATLSF 807

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1473 E-QKYQNEQVKVNKYIGKQESV------EERLSQLQSEnmllRQQLDDAHNKADNKEKTVINIQDQFHAIVQKLQAESEK 1545
Cdd:PRK04863   808 DvQKLQRLHQAFSRFIGSHLAVafeadpEAELRQLNRR----RVELERALADHESQEQQQRSQLEQAKEGLSALNRLLPR 883

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1546 QSLLLEERNKELISECN-HLKE--------RQYQYENEKAEREVVVRQLQQELADTLKKQSMSEASLEVTSRYRINLEDE 1616
Cdd:PRK04863   884 LNLLADETLADRVEEIReQLDEaeeakrfvQQHGNALAQLEPIVSVLQSDPEQFEQLKQDYQQAQQTQRDAKQQAFALTE 963

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1617 tqdlkkkLGQIRNQL--QEAQDRHTEAVRCAEKM-QDHKQKlEKDNAKLKVTVKKQMDKIEELQKNLLNANLSEDEKEQL 1693
Cdd:PRK04863   964 -------VVQRRAHFsyEDAAEMLAKNSDLNEKLrQRLEQA-EQERTRAREQLRQAQAQLAQYNQVLASLKSSYDAKRQM 1035

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1694 kkLMELKQSLEcnldqemkknvelereitgfknllkmtrkklneyengEFSFHGDlktsqFEMDIQinkLKHKIDDLTAE 1773
Cdd:PRK04863  1036 --LQELKQELQ-------------------------------------DLGVPAD-----SGAEER---ARARRDELHAR 1068

                          730       740       750       760
                   ....*....|....*....|....*....|....*....|....*...
gi 2462517825 1774 LETAGSKCLHLDTKNQILQEEllsMKTVQKKCEKLQKNKKKLEQEVIN 1821
Cdd:PRK04863  1069 LSANRSRRNQLEKQLTFCEAE---MDNLTKKLRKLERDYHEMREQVVN 1113
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 50-224 3.81e-03

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 42.17  E-value: 3.81e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825   50 IHKAASAGNVAKVQQiLLLRKNGLNDRDKMNRTALHLACANGHPEVVTLLVDRKCQLNVCDNEnrTALMKAVQCQEEKCA 129
Cdd:PHA02878    41 LHQAVEARNLDVVKS-LLTRGHNVNQPDHRDLTPLHIICKEPNKLGMKEMIRSINKCSVFYTL--VAIKDAFNNRNVEIF 117

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825  130 TILLEHGADPN--LADVHGNTALHYAVYNEDIsvaTKLLL-YDANIEAKNKDDL-TPLLLAVSGKKQQMVEFLIKKKANV 205
Cdd:PHA02878   118 KIILTNRYKNIqtIDLVYIDKKSKDDIIEAEI---TKLLLsYGADINMKDRHKGnTALHYATENKDQRLTELLLSYGANV 194

                          170       180
                   ....*....|....*....|.
gi 2462517825  206 NAVDKLESS--HQLISEYKEE 224
Cdd:PHA02878   195 NIPDKTNNSplHHAVKHYNKP 215
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 145-174 3.91e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 36.80  E-value: 3.91e-03
                            10        20        30
                    ....*....|....*....|....*....|
gi 2462517825   145 HGNTALHYAVYNEDISVATKLLLYDANIEA 174
Cdd:smart00248    1 DGRTPLHLAAENGNLEVVKLLLDKGADINA 30
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 1664-1956 4.00e-03

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 42.42  E-value: 4.00e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1664 VTVKKQMDKIEELQKNLLnanlsEDEKEQLKKLMELKQSLEcnlDQEMKKNVELEREITGF--KNLLKMTRKKLNEYENG 1741
Cdd:pfam17380  284 VSERQQQEKFEKMEQERL-----RQEKEEKAREVERRRKLE---EAEKARQAEMDRQAAIYaeQERMAMERERELERIRQ 355

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1742 EFSFHGDLKTSQFEMDIQINKLKhkiddltaELETAGskcLHLDTKNQILQEELLSMKTVQKKCEKLQKNkkkleqevin 1821
Cdd:pfam17380  356 EERKRELERIRQEEIAMEISRMR--------ELERLQ---MERQQKNERVRQELEAARKVKILEEERQRK---------- 414

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1822 lrshIERNMVELGQVKQYKQEIEERARQEIAE-KLKEVNLFLQAQAASQENLEQFRENNFASMKSQMELrikdlESELSK 1900
Cdd:pfam17380  415 ----IQQQKVEMEQIRAEQEEARQREVRRLEEeRAREMERVRLEEQERQQQVERLRQQEEERKRKKLEL-----EKEKRD 485

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 2462517825 1901 IKTSQEDFNKT---ELEKYKQLYLEELKVRKSLSSKLTKTNERLAEVNTKLLVEKQQSR 1956
Cdd:pfam17380  486 RKRAEEQRRKIlekELEERKQAMIEEERKRKLLEKEMEERQKAIYEEERRREAEEERRK 544
MukB COG3096
Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell ...
 1334-1737 4.13e-03

Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442330 [Multi-domain]  Cd Length: 1470  Bit Score: 42.25  E-value: 4.13e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1334 QYNGRLSVLTAE--------NAMLNSKLENEKQskERLEAEVESYHSRLAAAIHDRDQSETSKRELELAFQRARDECSRL 1405
Cdd:COG3096    317 ELSARESDLEQDyqaasdhlNLVQTALRQQEKI--ERYQEDLEELTERLEEQEEVVEEAAEQLAEAEARLEAAEEEVDSL 394

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1406 QdkmnfdvSNLKDNNEILSQQlfKTESklnsleIEFHHTRDALREktlglervqkdlSQTQCQMKEMEQkyqnEQVKvnk 1485
Cdd:COG3096    395 K-------SQLADYQQALDVQ--QTRA------IQYQQAVQALEK------------ARALCGLPDLTP----ENAE--- 440

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1486 yiGKQESVEERLSQLQSENMLLRQQL---DDAHNKADNKEKTVINIQDQfhaiVQKLQAESEKQSLLLEERnkelisECN 1562
Cdd:COG3096    441 --DYLAAFRAKEQQATEEVLELEQKLsvaDAARRQFEKAYELVCKIAGE----VERSQAWQTARELLRRYR------SQQ 508

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1563 HLKERQYQYENEKAEREVVVRQLQ--QELADTLKKQSmseaSLEVTSryRINLEDEtqdlkkklgqiRNQLQEAQDRHTE 1640
Cdd:COG3096    509 ALAQRLQQLRAQLAELEQRLRQQQnaERLLEEFCQRI----GQQLDA--AEELEEL-----------LAELEAQLEELEE 571

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1641 AVR-CAEKMQDHKQKLEKDNAKLKvTVKKQMDKIEELQKNLlnANLSEDEKEQLKKLMElkqslecnLDQEMKKNVELER 1719
Cdd:COG3096    572 QAAeAVEQRSELRQQLEQLRARIK-ELAARAPAWLAAQDAL--ERLREQSGEALADSQE--------VTAAMQQLLERER 640

                          410
                   ....*....|....*...
gi 2462517825 1720 EITGFKNLLKMTRKKLNE 1737
Cdd:COG3096    641 EATVERDELAARKQALES 658
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 1138-1368 4.24e-03

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 42.03  E-value: 4.24e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1138 LEHQKVEWERelcslrfslnQEEEKrrnadtlYEKI-REQLRRKEEQYRKEVEVKQQLELSLQTLEMELR---TVKSNLN 1213
Cdd:pfam17380  278 VQHQKAVSER----------QQQEK-------FEKMeQERLRQEKEEKAREVERRRKLEEAEKARQAEMDrqaAIYAEQE 340

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1214 QVVQERN---DAQRQLSREQNARMLQDGILTNHLSKQKEIEMAQKKMNSENSHShEEEKDLSHKNSMLQEE----IAMLR 1286
Cdd:pfam17380  341 RMAMERErelERIRQEERKRELERIRQEEIAMEISRMRELERLQMERQQKNERV-RQELEAARKVKILEEErqrkIQQQK 419

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1287 LEIDTIKNQNQEKEKkcfEDLKIVKEKNEDLQKTIKQNEETLTQTISqyngRLSVLTAENAmlNSKLENEKQSKERLEAE 1366
Cdd:pfam17380  420 VEMEQIRAEQEEARQ---REVRRLEEERAREMERVRLEEQERQQQVE----RLRQQEEERK--RKKLELEKEKRDRKRAE 490


                   ..
gi 2462517825 1367 VE 1368
Cdd:pfam17380  491 EQ 492
PRK10929 PRK10929
putative mechanosensitive channel protein; Provisional
 1201-1524 4.44e-03

putative mechanosensitive channel protein; Provisional


Pssm-ID: 236798 [Multi-domain]  Cd Length: 1109  Bit Score: 42.35  E-value: 4.44e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1201 LEMELRTVKSNLN----QVVQERNDAQRQLSR----EQNARMLQDGI-----LTNHLSKQKEIEMAQKKMNSENSHSHEE 1267
Cdd:PRK10929    28 ITQELEQAKAAKTpaqaEIVEALQSALNWLEErkgsLERAKQYQQVIdnfpkLSAELRQQLNNERDEPRSVPPNMSTDAL 107

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1268 EKDLSHKNSMLQEEIAMLrleidtikNQNQEKEKKCFEDLKIVKEKNEDLQKTIKQNEETLtQTISQYN-----GRLSVL 1342
Cdd:PRK10929   108 EQEILQVSSQLLEKSRQA--------QQEQDRAREISDSLSQLPQQQTEARRQLNEIERRL-QTLGTPNtplaqAQLTAL 178

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1343 TAENAMLNSKLE---------NEKQSKERLEAEV-ESYHSRLAAAIHD-RDQ-SETSKRELELAFQRARDECSRLQDKMN 1410
Cdd:PRK10929   179 QAESAALKALVDelelaqlsaNNRQELARLRSELaKKRSQQLDAYLQAlRNQlNSQRQREAERALESTELLAEQSGDLPK 258

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1411 FDVSNLKDNNEI---LSQQ------LFKTESKLNSLEIEFHHTRDALREKT--LGLERVQKDLSQTQ-CQMKEMEqKYQn 1478
Cdd:PRK10929   259 SIVAQFKINRELsqaLNQQaqrmdlIASQQRQAASQTLQVRQALNTLREQSqwLGVSNALGEALRAQvARLPEMP-KPQ- 336

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|....*.
gi 2462517825 1479 eQVKvnkyigkQESVEERLSQLQSENMLLRQQLDDAHNKADNKEKT 1524
Cdd:PRK10929   337 -QLD-------TEMAQLRVQRLRYEDLLNKQPQLRQIRQADGQPLT 374
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 1683-1911 4.72e-03

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 41.67  E-value: 4.72e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1683 ANLSEDEKEQLKKLMELKQSLECNLDQEMKKNVELEREITGFKNLLKMTRKKLNEYENgefsfhgdlktsqfemdiQINK 1762
Cdd:COG4942     19 ADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQ------------------ELAA 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1763 LKHKIDDLTAELETAGSKclhLDTKNQILQEELLSM-KTVQKKCEKL---QKNKKKLEQEVINLRSHIERNMVELGQVKQ 1838
Cdd:COG4942     81 LEAELAELEKEIAELRAE---LEAQKEELAELLRALyRLGRQPPLALllsPEDFLDAVRRLQYLKYLAPARREQAEELRA 157

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462517825 1839 YKQEIEERaRQEIAEKLKEVNLFLQAQAASQENLEQfRENNFASMKSQMELRIKDLESELSKIKTSQEDFNKT 1911
Cdd:COG4942    158 DLAELAAL-RAELEAERAELEALLAELEEERAALEA-LKAERQKLLARLEKELAELAAELAELQQEAEELEAL 228
PHA02946 PHA02946
ankyin-like protein; Provisional
 96-215 4.76e-03

ankyin-like protein; Provisional


Pssm-ID: 165256 [Multi-domain]  Cd Length: 446  Bit Score: 41.96  E-value: 4.76e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825   96 VTLLVDRKCQLNVCDNENRTALMKAVQCQEEKCATILLEHGADPNLADVHGNTALHYAVYNED--ISVATKLLLYDANIE 173
Cdd:PHA02946    55 VEELLHRGYSPNETDDDGNYPLHIASKINNNRIVAMLLTHGADPNACDKQHKTPLYYLSGTDDevIERINLLVQYGAKIN 134

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|..
gi 2462517825  174 AKNKDDLTPLLLAVSGKKQQMVEFLIKKKANVNAVDKLESSH 215
Cdd:PHA02946   135 NSVDEEGCGPLLACTDPSERVFKKIMSIGFEARIVDKFGKNH 176
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 1354-1633 5.03e-03

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 42.03  E-value: 5.03e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1354 ENEKQSKERLEAEVESYHSRLAAAIH---DRDQSETSKRELELAFQRARD-ECSRLQDKMNFDVSNLKDNNEIlsQQLFK 1429
Cdd:pfam17380  322 EKARQAEMDRQAAIYAEQERMAMERErelERIRQEERKRELERIRQEEIAmEISRMRELERLQMERQQKNERV--RQELE 399

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1430 TESKLNSLEIEFHHTRDALREKTLGLERVQKDLSQTQCQMKEMEQKYQNEQVKVnkyigkqesvEERLSQLQSEnmLLRQ 1509
Cdd:pfam17380  400 AARKVKILEEERQRKIQQQKVEMEQIRAEQEEARQREVRRLEEERAREMERVRL----------EEQERQQQVE--RLRQ 467

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1510 QLDDAHNKADNKEKTVIN---IQDQFHAIVQKlQAESEKQSLLlEERNKELISEcNHLKERQYQ-YENEKAEREVVVRQL 1585
Cdd:pfam17380  468 QEEERKRKKLELEKEKRDrkrAEEQRRKILEK-ELEERKQAMI-EEERKRKLLE-KEMEERQKAiYEEERRREAEEERRK 544

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....*....
gi 2462517825 1586 QQELADTLK-KQSMSEASLEvtsRYRINLEDETQDLKKKLGQIRNQLQE 1633
Cdd:pfam17380  545 QQEMEERRRiQEQMRKATEE---RSRLEAMEREREMMRQIVESEKARAE 590
PRK12704 PRK12704
phosphodiesterase; Provisional
 1662-1857 5.20e-03

phosphodiesterase; Provisional


Pssm-ID: 237177 [Multi-domain]  Cd Length: 520  Bit Score: 41.69  E-value: 5.20e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1662 LKVTVKKQMDKIEELQKNLLNAnlSEDEKEQLKKLMELKQSlecnlDQEMKKNVELEREItgfknllkmtRKKLNEYENG 1741
Cdd:PRK12704    25 RKKIAEAKIKEAEEEAKRILEE--AKKEAEAIKKEALLEAK-----EEIHKLRNEFEKEL----------RERRNELQKL 87

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1742 EfsfhgdlktsqfemdiqiNKLKHKIDDLTAELETAGSKCLHLDTKNQILQEELLSMKTVQKKCEKLQKNKKKLEQEVIN 1821
Cdd:PRK12704    88 E------------------KRLLQKEENLDRKLELLEKREEELEKKEKELEQKQQELEKKEEELEELIEEQLQELERISG 149

                          170       180       190
                   ....*....|....*....|....*....|....*.
gi 2462517825 1822 LRSHIERNMVelgqvkqyKQEIEERARQEIAEKLKE 1857
Cdd:PRK12704   150 LTAEEAKEIL--------LEKVEEEARHEAAVLIKE 177
PRK09039 PRK09039
peptidoglycan -binding protein;
1328-1438 5.34e-03

peptidoglycan -binding protein;


Pssm-ID: 181619 [Multi-domain]  Cd Length: 343  Bit Score: 41.49  E-value: 5.34e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1328 LTQTISQYNGRLSVLTAENAMLNSKLENEKQSKERLEAEVESYHSRLAAAIHDRDQSETSKRELElafqRARDECSRLQD 1407
Cdd:PRK09039    44 LSREISGKDSALDRLNSQIAELADLLSLERQGNQDLQDSVANLRASLSAAEAERSRLQALLAELA----GAGAAAEGRAG 119

                           90       100       110
                   ....*....|....*....|....*....|....*...
gi 2462517825 1408 KMNFDVSNLKDNN-------EILSQQLFKTESKLNSLE 1438
Cdd:PRK09039   120 ELAQELDSEKQVSaralaqvELLNQQIAALRRQLAALE 157
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
 1110-1649 5.65e-03

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 42.08  E-value: 5.65e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1110 LTVKIKKMEDKVNVLQRELSETKEIKSQLEH-------QKVEWERELCSLRFSLNQEEEKRRNADTLYEKIREQLRRKEE 1182
Cdd:pfam01576  487 LSTRLRQLEDERNSLQEQLEEEEEAKRNVERqlstlqaQLSDMKKKLEEDAGTLEALEEGKKRLQRELEALTQQLEEKAA 566

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1183 QYRKEVEVKQQLELSLQTLEMEL---RTVKSNL------------------NQVVQERNDAQRQlSREQNARMLQ-DGIL 1240
Cdd:pfam01576  567 AYDKLEKTKNRLQQELDDLLVDLdhqRQLVSNLekkqkkfdqmlaeekaisARYAEERDRAEAE-AREKETRALSlARAL 645

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1241 TNHLSKQKEIEMAQKKMNSENSHSHEEEKDLSHKNSMLQEEIAMLRLEIDTIKNQNQEKEK--KCFEDLKIVKEKN---- 1314
Cdd:pfam01576  646 EEALEAKEELERTNKQLRAEMEDLVSSKDDVGKNVHELERSKRALEQQVEEMKTQLEELEDelQATEDAKLRLEVNmqal 725

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1315 -----EDLQKTIKQNEETLTQTISQyngrLSVLTAEnamlnskLENEKQ-------SKERLEAEVESYHSRLAAAIHDRD 1382
Cdd:pfam01576  726 kaqfeRDLQARDEQGEEKRRQLVKQ----VRELEAE-------LEDERKqraqavaAKKKLELDLKELEAQIDAANKGRE 794

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1383 QSETSKRELELA---FQRARDECSRLQDkmnfdvsnlkdnnEILSQQLfKTESKLNSLEIEFHHtrdaLREKTLGLERVQ 1459
Cdd:pfam01576  795 EAVKQLKKLQAQmkdLQRELEEARASRD-------------EILAQSK-ESEKKLKNLEAELLQ----LQEDLAASERAR 856

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1460 KdlsQTQCQMKEMEQKYQNEQVKVNKYIGKQESVEERLSQLQSEnmllrqqLDDAHNKADNKEKTVINIQDQFHAIVQKL 1539
Cdd:pfam01576  857 R---QAQQERDELADEIASGASGKSALQDEKRRLEARIAQLEEE-------LEEEQSNTELLNDRLRKSTLQVEQLTTEL 926

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1540 QAE------SEKQSLLLEERNKELISECNHLKER-QYQYENEKAEREVVVRQLQQELADTLKKQSMS------------E 1600
Cdd:pfam01576  927 AAErstsqkSESARQQLERQNKELKAKLQEMEGTvKSKFKSSIAALEAKIAQLEEQLEQESRERQAAnklvrrtekklkE 1006

                          570       580       590       600       610
                   ....*....|....*....|....*....|....*....|....*....|.
gi 2462517825 1601 ASLEVTSRYRI--NLEDETQDLKKKLGQIRNQLQEAQDRHTEAVRCAEKMQ 1649
Cdd:pfam01576 1007 VLLQVEDERRHadQYKDQAEKGNSRMKQLKRQLEEAEEEASRANAARRKLQ 1057
CCCAP pfam15964
Centrosomal colon cancer autoantigen protein family; CCCAP is a family of proteins found in ...
 1110-1330 6.48e-03

Centrosomal colon cancer autoantigen protein family; CCCAP is a family of proteins found in eukaryotes. CCCAP is also known as SDCCAG8, serologically defined colon cancer antigen 8. It is associated with the centrosome.


Pssm-ID: 435040 [Multi-domain]  Cd Length: 703  Bit Score: 41.43  E-value: 6.48e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1110 LTVKIKKMEDKVNVLQRE----LSETKEIKSQLEHQKVEWERELCSLRFSLNQEEEKRRNADTLYEKIREQLRRKEEQYR 1185
Cdd:pfam15964  408 LSQNVAQLEAQVEKVTREknslVSQLEEAQKQLASQEMDVTKVCGEMRYQLNQTKMKKDEAEKEHREYRTKTGRQLEIKD 487

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1186 KEVEvKQQLELSLQTLEME-------------------LRTVKSNLNQVVQERNDAQRQLSREQNARMLQdgiltnhlSK 1246
Cdd:pfam15964  488 QEIE-KLGLELSESKQRLEqaqqdaarareeclkltelLGESEHQLHLTRLEKESIQQSFSNEAKAQALQ--------AQ 558

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1247 QKEIEMAQKKMNSENSHS---HEEEKDLSHKNSM---LQEEIAMLRLEIDTIKNQNQEKEKKCFEDLKIVKEKNEDLQKT 1320
Cdd:pfam15964  559 QREQELTQKMQQMEAQHDktvNEQYSLLTSQNTFiakLKEECCTLAKKLEEITQKSRSEVEQLSQEKEYLQDRLEKLQKR 638

                          250
                   ....*....|
gi 2462517825 1321 IKQNEETLTQ 1330
Cdd:pfam15964  639 NEELEEQCVQ 648
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 95-209 6.65e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 41.59  E-value: 6.65e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825   95 VVTLLVDRKCQLNVCDNENRTALMKAVQCQEEKCATILLEHGADPNLADVHGNTALHYAVYNEDISVATKLLLYDANIea 174
Cdd:PHA02876   160 IAEMLLEGGADVNAKDIYCITPIHYAAERGNAKMVNLLLSYGADVNIIALDDLSVLECAVDSKNIDTIKAIIDNRSNI-- 237

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 2462517825  175 kNKDDLTpLLLAVSGKKQQMVEFLIKKKANVNAVD 209
Cdd:PHA02876   238 -NKNDLS-LLKAIRNEDLETSLLLYDAGFSVNSID 270
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
1274-1657 7.05e-03

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 41.29  E-value: 7.05e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1274 KNSMLQEEIAMLRLEIDTIKNQNQEkekkcFEDLKIVKEKNEDLQKTIKQNEETLTQTISQYNGRLSVLTAENAM--LNS 1351
Cdd:COG4717     65 KPELNLKELKELEEELKEAEEKEEE-----YAELQEELEELEEELEELEAELEELREELEKLEKLLQLLPLYQELeaLEA 139

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1352 KLENEKQSKERLEAEVESYHSRLAAAIHDRDQSETSKRELELAFQRARDECSRLQDKMNFDVSNLKDNNEILSQQLFKTE 1431
Cdd:COG4717    140 ELAELPERLEELEERLEELRELEEELEELEAELAELQEELEELLEQLSLATEEELQDLAEELEELQQRLAELEEELEEAQ 219

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1432 SKLNSLEIEFHHTRDALREKTLgLERVQK-----------------------------------------DLSQTQCQMK 1470
Cdd:COG4717    220 EELEELEEELEQLENELEAAAL-EERLKEarlllliaaallallglggsllsliltiagvlflvlgllalLFLLLAREKA 298

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1471 EMEQKYQNEQVKVNKYIGKQESVEERLSQLQSENMLLRQQLDDAHNKADNKEKTVINIQDQFHAIvqKLQAESEKQSLLL 1550
Cdd:COG4717    299 SLGKEAEELQALPALEELEEEELEELLAALGLPPDLSPEELLELLDRIEELQELLREAEELEEEL--QLEELEQEIAALL 376

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1551 EERNKELISECNHLKERQYQYENEKAEREVVVRQLQQ------ELADTLKKQSMSEASLEVTSRYRiNLEDETQDLKKKL 1624
Cdd:COG4717    377 AEAGVEDEEELRAALEQAEEYQELKEELEELEEQLEEllgeleELLEALDEEELEEELEELEEELE-ELEEELEELREEL 455

                          410       420       430
                   ....*....|....*....|....*....|...
gi 2462517825 1625 GQIRNQLQEAQDRHteavRCAEKMQDHKQKLEK 1657
Cdd:COG4717    456 AELEAELEQLEEDG----ELAELLQELEELKAE 484
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 1612-1948 7.24e-03

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 41.54  E-value: 7.24e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1612 NLEDETQDLKKKLGQIRNQLQEAQDRHTEAVRCAEKMQDHKQKLEKDNAKLKVTVKKQMDKIEELQKNLLNANLSEDEKE 1691
Cdd:TIGR04523   37 QLEKKLKTIKNELKNKEKELKNLDKNLNKDEEKINNSNNKIKILEQQIKDLNDKLKKNKDKINKLNSDLSKINSEIKNDK 116

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1692 QLKKLMELKQSlecNLDQEMKKNvelEREITGFKNLLKMTRKKLNEYENGefsfHGDLKTSQFEMDIQINKLKHKIDDLT 1771
Cdd:TIGR04523  117 EQKNKLEVELN---KLEKQKKEN---KKNIDKFLTEIKKKEKELEKLNNK----YNDLKKQKEELENELNLLEKEKLNIQ 186

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1772 AELETAGSKCLHLDTKnqilqeeLLSMKTVQKKCEKLQKNKKKLEQEVINLRSHIERNMVELGQVKQYKQEIEERARQEI 1851
Cdd:TIGR04523  187 KNIDKIKNKLLKLELL-------LSNLKKKIQKNKSLESQISELKKQNNQLKDNIEKKQQEINEKTTEISNTQTQLNQLK 259

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1852 AEKLKEVNLFLQAQAASQENLEQfrennfasmksqmelrIKDLESELSKIKTSQEDFNKTELEKYKQLYLEELKVRKS-- 1929
Cdd:TIGR04523  260 DEQNKIKKQLSEKQKELEQNNKK----------------IKELEKQLNQLKSEISDLNNQKEQDWNKELKSELKNQEKkl 323

                          330       340
                   ....*....|....*....|.
gi 2462517825 1930 --LSSKLTKTNERLAEVNTKL 1948
Cdd:TIGR04523  324 eeIQNQISQNNKIISQLNEQI 344
PTZ00121 PTZ00121
MAEBL; Provisional
 1115-1433 7.37e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 41.67  E-value: 7.37e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1115 KKMEDKVNVLQRELSETKEIKSQLEHQKVEWERELCSLRFSLNQEEEKR-----RNADTLYEKIREQLRRKEEQYRKEVE 1189
Cdd:PTZ00121  1627 KAEEEKKKVEQLKKKEAEEKKKAEELKKAEEENKIKAAEEAKKAEEDKKkaeeaKKAEEDEKKAAEALKKEAEEAKKAEE 1706

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1190 VKQQLELSLQTLEMELRTVKSNLNQVVQERNDAQRQLSREQNARmlqdgiltnhlskqKEIEMAQKKMNSENSHSHEEEK 1269
Cdd:PTZ00121  1707 LKKKEAEEKKKAEELKKAEEENKIKAEEAKKEAEEDKKKAEEAK--------------KDEEEKKKIAHLKKEEEKKAEE 1772

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1270 DLSHKNSMLQEEiamLRLEIDTIKNQNQEKEKKCFEDLKIVKEKNEDLQKTIKQNEETLTQTISQyngrlsVLTAENAML 1349
Cdd:PTZ00121  1773 IRKEKEAVIEEE---LDEEDEKRRMEVDKKIKDIFDNFANIIEGGKEGNLVINDSKEMEDSAIKE------VADSKNMQL 1843

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1350 NS--KLENEKQSKERLEAEVESYHSRLAAAIHDRDQSETSKRELELAFQRARDECSRLQDKMNFDvsnlKDNNEILSQQL 1427
Cdd:PTZ00121  1844 EEadAFEKHKFNKNNENGEDGNKEADFNKEKDLKEDDEEEIEEADEIEKIDKDDIEREIPNNNMA----GKNNDIIDDKL 1919


                   ....*.
gi 2462517825 1428 FKTESK 1433
Cdd:PTZ00121  1920 DKDEYI 1925
DUF3584 pfam12128
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ...
 1155-1464 7.59e-03

Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.


Pssm-ID: 432349 [Multi-domain]  Cd Length: 1191  Bit Score: 41.36  E-value: 7.59e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1155 SLNQEEEKRRNADTLYEKI---REQLRRKEEQY---RKEVE-VKQQLELSLQTLEMELRTVKSNLNQVVQERNDAQRQLS 1227
Cdd:pfam12128  595 WAASEEELRERLDKAEEALqsaREKQAAAEEQLvqaNGELEkASREETFARTALKNARLDLRRLFDEKQSEKDKKNKALA 674

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1228 REQNARMLQ----DGILTNHLSKQKEIEMAQKKMNSENSHSHEE-----EKDLSHKNSMLQEEIAMLRLEIDTIKNQNQE 1298
Cdd:pfam12128  675 ERKDSANERlnslEAQLKQLDKKHQAWLEEQKEQKREARTEKQAywqvvEGALDAQLALLKAAIAARRSGAKAELKALET 754

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1299 KEKKCFEDLKIVKEKNEDLQKTIKqneeTLTQTISQYNGRLSVLTAENAMLNSKLENEKQSKERLEAEVESYHSRLAAAI 1378
Cdd:pfam12128  755 WYKRDLASLGVDPDVIAKLKREIR----TLERKIERIAVRRQEVLRYFDWYQETWLQRRPRLATQLSNIERAISELQQQL 830

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1379 hDRDQSETSKRELELafQRARDECSRLQDKMNFDVSNLKDNNEILSQqlFKTESKLNSLEIEFHHTRDALREKTLGLERV 1458
Cdd:pfam12128  831 -ARLIADTKLRRAKL--EMERKASEKQQVRLSENLRGLRCEMSKLAT--LKEDANSEQAQGSIGERLAQLEDLKLKRDYL 905


                   ....*.
gi 2462517825 1459 QKDLSQ 1464
Cdd:pfam12128  906 SESVKK 911
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 1422-1643 7.93e-03

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 40.90  E-value: 7.93e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1422 ILSQQLFKTESKLNSLEIEFHHTRDALREKTLGLERVQKDLSQTQCQMKEMEQKYQNEQVKVNKYIGKQESVEERLSQLQ 1501
Cdd:COG4942     10 LLALAAAAQADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELE 89

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1502 SENMLLRQQLDD-----------AHNKADNKEKTVINIQDQFHAIVQKLQAeSEKQSLLLEERNKELISECNHLKERQYQ 1570
Cdd:COG4942     90 KEIAELRAELEAqkeelaellraLYRLGRQPPLALLLSPEDFLDAVRRLQY-LKYLAPARREQAEELRADLAELAALRAE 168

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462517825 1571 YENEKAEREVVVRQLQQELADTLKKQSMSEASLEVTSRYRINLEDETQDLKKKLGQIRNQLQEAQDRHTEAVR 1643
Cdd:COG4942    169 LEAERAELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAEAAAAAE 241
ClyA_Cry6Aa-like cd22656
Bacillus thuringiensis crystal 6Aa (Cry6Aa) toxin, and similar proteins; This model includes ...
 1614-1737 8.29e-03

Bacillus thuringiensis crystal 6Aa (Cry6Aa) toxin, and similar proteins; This model includes pesticidal Cry6Aa toxin from Bacillus thuringiensis, one of the many parasporal crystal (Cry) toxins produced during the sporulation phase of growth. Many of these proteins are toxic to numerous insect species and have been effectively used as proteinaceous insecticides to directly kill insect pests; some have been used to control insect growth on transgenic agricultural plants. Cry6Aa exists as a protoxin, which is activated by cleavage using trypsin. Structure studies for Cry6Aa support a mechanism of action by pore formation, similar to cytolysin A (ClyA)-type alpha pore-forming toxins (alpha-PFTs) such as HblB, and bioassay and mutation studies show that Cry6Aa is an active pore-forming toxin. Cry6Aa shows atypical features compared to other members of alpha-PFTs, including internal repeat sequences and small loop regions within major alpha helices.


Pssm-ID: 439154 [Multi-domain]  Cd Length: 309  Bit Score: 40.43  E-value: 8.29e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1614 EDETQDLKKKL-GQIRNQLQEAQDRHTEAVRCAEKMQDHKQKLEKDNAKLKvTVKKQMD-------------KIEELQKN 1679
Cdd:cd22656    109 DEELEEAKKTIkALLDDLLKEAKKYQDKAAKVVDKLTDFENQTEKDQTALE-TLEKALKdlltdeggaiarkEIKDLQKE 187

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 2462517825 1680 LLNANlsEDEKEQLKKLMELKQSLECNLDQEMKKNVELEREITGFKNLLKMTRKKLNE 1737
Cdd:cd22656    188 LEKLN--EEYAAKLKAKIDELKALIADDEAKLAAALRLIADLTAADTDLDNLLALIGP 243
Lebercilin pfam15619
Ciliary protein causing Leber congenital amaurosis disease; Lebercilin is a family of ...
 1174-1302 8.82e-03

Ciliary protein causing Leber congenital amaurosis disease; Lebercilin is a family of eukaryotic ciliary proteins. Mutations in the gene, LCA5, are implicated in the disease Leber congenital amaurosis. In photoreceptors, lebercilin is uniquely localized at the cilium that bridges the inner and outer segments. Lebercilin functions as an integral element of selective protein transport through photoreceptor cilia. Lebercilin specifically interacts with the intraflagellar transport (IFT), and disruption of IFT can lead to Leber congenital amaurosis.


Pssm-ID: 464776 [Multi-domain]  Cd Length: 193  Bit Score: 39.50  E-value: 8.82e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1174 REQLRRKEEQYRkevevkqQLELSLQTLEMELRTVKSNLNQVVQ--------ERNDAQRQLSREQNarMLQDgiltnhls 1245
Cdd:pfam15619   73 RERLRRLQEKER-------DLERKLKEKEAELLRLRDQLKRLEKlsedknlaEREELQKKLEQLEA--KLED-------- 135

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 2462517825 1246 KQKEIEMAQKKM-NSENSHSHEEEKDLShKNSMLQEEIAMLRLEIDTIKNQNQEKEKK 1302
Cdd:pfam15619  136 KDEKIQDLERKLeLENKSFRRQLAAEKK-KHKEAQEEVKILQEEIERLQQKLKEKERE 192
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 1097-1300 9.02e-03

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 41.26  E-value: 9.02e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1097 ERLLELKKNHCELLTVKIKKMEDKVNVLQRELSETKEIKSQLEHQKVEWERELCSLRfslnQEEEKRRNADTLYEKIREQ 1176
Cdd:pfam17380  410 ERQRKIQQQKVEMEQIRAEQEEARQREVRRLEEERAREMERVRLEEQERQQQVERLR----QQEEERKRKKLELEKEKRD 485

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1177 LRRKEEQYRKEVEvkQQLELSLQTLEMELRTVKsnlnQVVQERNDAQRQLSREQNARMLQDgiltnhlSKQKEIEMAQKK 1256
Cdd:pfam17380  486 RKRAEEQRRKILE--KELEERKQAMIEEERKRK----LLEKEMEERQKAIYEEERRREAEE-------ERRKQQEMEERR 552

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....
gi 2462517825 1257 MNSENSHSHEEEKDlshKNSMLQEEIAMLRleiDTIKNQNQEKE 1300
Cdd:pfam17380  553 RIQEQMRKATEERS---RLEAMEREREMMR---QIVESEKARAE 590
PRK11281 PRK11281
mechanosensitive channel MscK;
1450-1680 9.09e-03

mechanosensitive channel MscK;


Pssm-ID: 236892 [Multi-domain]  Cd Length: 1113  Bit Score: 41.44  E-value: 9.09e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1450 EKTLGL----ERVQKDLSQTQCQMKEMEQKYQNEQVKVNKYIGK-QESVEERLSQL---QSENML--LRQQLDDAHNKAD 1519
Cdd:PRK11281    66 EQTLALldkiDRQKEETEQLKQQLAQAPAKLRQAQAELEALKDDnDEETRETLSTLslrQLESRLaqTLDQLQNAQNDLA 145

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1520 NKEKTVINIQDQFHAiVQKLQAESEKQSLLLEER-NKELISECNHLKERQYQYENEKAEREVVVRQLQQELADTLKKQSM 1598
Cdd:PRK11281   146 EYNSQLVSLQTQPER-AQAALYANSQRLQQIRNLlKGGKVGGKALRPSQRVLLQAEQALLNAQNDLQRKSLEGNTQLQDL 224

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517825 1599 SEASLEVTSRYRINLEDETQDLK-----KKLGQIRNQLQEAQdrhteAVRCAEKMQDH---KQKLEKdNAKLKVTVKKQM 1670
Cdd:PRK11281   225 LQKQRDYLTARIQRLEHQLQLLQeainsKRLTLSEKTVQEAQ-----SQDEAARIQANplvAQELEI-NLQLSQRLLKAT 298

                          250
                   ....*....|.
gi 2462517825 1671 DKIEEL-QKNL 1680
Cdd:PRK11281   299 EKLNTLtQQNL 309
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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