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Conserved domains on  [gi|2462519535|ref|XP_054222010|]
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WW domain-containing adapter protein with coiled-coil isoform X4 [Homo sapiens]

Protein Classification

WW domain-containing protein( domain architecture ID 10449603)

WW domain-containing protein; the WW domain mediates protein-protein interaction via proline-rich motifs, such as PPxY

CATH:  2.20.70.10
Gene Ontology:  GO:0005515
PubMed:  22201747|9029943
SCOP:  3001621

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
WW pfam00397
WW domain; The WW domain is a protein module with two highly conserved tryptophans that binds ...
 133-160 3.94e-09

WW domain; The WW domain is a protein module with two highly conserved tryptophans that binds proline-rich peptide motifs in vitro.


:

Pssm-ID: 459800 [Multi-domain]  Cd Length: 30  Bit Score: 52.12  E-value: 3.94e-09
                          10        20
                  ....*....|....*....|....*...
gi 2462519535 133 DDWSEHISSSGKKYYYNCRTEVSQWEKP 160
Cdd:pfam00397   3 PGWEERWDPDGRVYYYNHETGETQWEKP 30
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 235-527 5.44e-07

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 53.40  E-value: 5.44e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462519535  235 PRAETHSSSTPVQHPIKPvvhPTATPSTVPSSPFTLQSDHQPKKSFDANGASTLSKLPTPTSSVPAQKTERKESTSGDKP 314
Cdd:PHA03247  2609 RGPAPPSPLPPDTHAPDP---PPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRR 2685

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462519535  315 VSHSCTTPSTSSASglNPTSAPPTSASAvPVSPVPQSPIPPLLQDPNLLRQLLPALQATLQLNNSNVDISKINEVLTAAV 394
Cdd:PHA03247  2686 RAARPTVGSLTSLA--DPPPPPPTPEPA-PHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPT 2762

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462519535  395 TQASLQSIIHKFLTAGPSAfNITSLISQAAQLSTQAQPSNQSPMSLTSDASSPRSYVSPRIS-----TPQTNTVPIKPLI 469
Cdd:PHA03247  2763 TAGPPAPAPPAAPAAGPPR-RLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASpagplPPPTSAQPTAPPP 2841

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 2462519535  470 STPPVSSQPKVSTPVVKQGPVSQSA-TQQPVTADKQQGHEPVSpRSLQRSSQRSPSPGP 527
Cdd:PHA03247  2842 PPGPPPPSLPLGGSVAPGGDVRRRPpSRSPAAKPAAPARPPVR-RLARPAVSRSTESFA 2899
PRP40 super family cl34905
Splicing factor [RNA processing and modification];
131-198 3.65e-03

Splicing factor [RNA processing and modification];


The actual alignment was detected with superfamily member COG5104:

Pssm-ID: 227435 [Multi-domain]  Cd Length: 590  Bit Score: 40.45  E-value: 3.65e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462519535 131 SADDWSEHISSSGKKYYYNCRTEVSQWEKPKEW--LEREQRQKEA---------NKMAVNSFPKD---RDYRREVMQATA 196
Cdd:COG5104    54 DVDPWKECRTADGKVYYYNSITRESRWKIPPERkkVEPIAEQKHDersmiggngNDMAITDHETSepkYLLGRLMSQYGI 133


                  ..
gi 2462519535 197 TS 198
Cdd:COG5104   134 TS 135
 
Name Accession Description Interval E-value
WW pfam00397
WW domain; The WW domain is a protein module with two highly conserved tryptophans that binds ...
 133-160 3.94e-09

WW domain; The WW domain is a protein module with two highly conserved tryptophans that binds proline-rich peptide motifs in vitro.


Pssm-ID: 459800 [Multi-domain]  Cd Length: 30  Bit Score: 52.12  E-value: 3.94e-09
                          10        20
                  ....*....|....*....|....*...
gi 2462519535 133 DDWSEHISSSGKKYYYNCRTEVSQWEKP 160
Cdd:pfam00397   3 PGWEERWDPDGRVYYYNHETGETQWEKP 30
WW cd00201
Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; ...
 133-162 1.45e-08

Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other peptide recognition proteins such as antibodies and receptors; WW domains have a single groove formed by a conserved Trp and Tyr which recognizes a pair of residues of the sequence X-Pro; variable loops and neighboring domains confer specificity in this domain; there are five distinct groups based on binding: 1) PPXY motifs 2) the PPLP motif; 3) PGM motifs; 4) PSP or PTP motifs; 5) PR motifs.


Pssm-ID: 238122 [Multi-domain]  Cd Length: 31  Bit Score: 50.60  E-value: 1.45e-08
                          10        20        30
                  ....*....|....*....|....*....|
gi 2462519535 133 DDWSEHISSSGKKYYYNCRTEVSQWEKPKE 162
Cdd:cd00201     2 PGWEERWDPDGRVYYYNHNTKETQWEDPRE 31
PHA03247 PHA03247
large tegument protein UL36; Provisional
 235-527 5.44e-07

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 53.40  E-value: 5.44e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462519535  235 PRAETHSSSTPVQHPIKPvvhPTATPSTVPSSPFTLQSDHQPKKSFDANGASTLSKLPTPTSSVPAQKTERKESTSGDKP 314
Cdd:PHA03247  2609 RGPAPPSPLPPDTHAPDP---PPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRR 2685

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462519535  315 VSHSCTTPSTSSASglNPTSAPPTSASAvPVSPVPQSPIPPLLQDPNLLRQLLPALQATLQLNNSNVDISKINEVLTAAV 394
Cdd:PHA03247  2686 RAARPTVGSLTSLA--DPPPPPPTPEPA-PHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPT 2762

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462519535  395 TQASLQSIIHKFLTAGPSAfNITSLISQAAQLSTQAQPSNQSPMSLTSDASSPRSYVSPRIS-----TPQTNTVPIKPLI 469
Cdd:PHA03247  2763 TAGPPAPAPPAAPAAGPPR-RLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASpagplPPPTSAQPTAPPP 2841

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 2462519535  470 STPPVSSQPKVSTPVVKQGPVSQSA-TQQPVTADKQQGHEPVSpRSLQRSSQRSPSPGP 527
Cdd:PHA03247  2842 PPGPPPPSLPLGGSVAPGGDVRRRPpSRSPAAKPAAPARPPVR-RLARPAVSRSTESFA 2899
WW smart00456
Domain with 2 conserved Trp (W) residues; Also known as the WWP or rsp5 domain. Binds ...
 135-162 1.25e-06

Domain with 2 conserved Trp (W) residues; Also known as the WWP or rsp5 domain. Binds proline-rich polypeptides.


Pssm-ID: 197736 [Multi-domain]  Cd Length: 33  Bit Score: 45.28  E-value: 1.25e-06
                           10        20
                   ....*....|....*....|....*...
gi 2462519535  135 WSEHISSSGKKYYYNCRTEVSQWEKPKE 162
Cdd:smart00456   6 WEERKDPDGRPYYYNHETKETQWEKPRE 33
DUF5585 pfam17823
Family of unknown function (DUF5585); This is a family of unknown function found in chordata.
 252-523 3.00e-04

Family of unknown function (DUF5585); This is a family of unknown function found in chordata.


Pssm-ID: 465521 [Multi-domain]  Cd Length: 506  Bit Score: 43.80  E-value: 3.00e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462519535 252 PVVHPTATPSTVPSSpFTLQSDHQPKKSFDANGASTLSklpTPTSSVPAQKTERKESTSGDKPVSHSCTTPSTSSASGLN 331
Cdd:pfam17823 115 LAAAASSSPSSAAQS-LPAAIAALPSEAFSAPRAAACR---ANASAAPRAAIAAASAPHAASPAPRTAASSTTAASSTTA 190

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462519535 332 PTSAPPTSASAVPVSPVPQSPIppllqDPNLLRQLLPALQATLQLNNSNVDISKINEVLTAAVTQASLQSIIHKFLTAGP 411
Cdd:pfam17823 191 ASSAPTTAASSAPATLTPARGI-----STAATATGHPAAGTALAAVGNSSPAAGTVTAAVGTVTPAALATLAAAAGTVAS 265

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462519535 412 SAfnitSLISQAAQLSTQAQPSNQSPMSltSDASSPRSYVSPRISTPQTNTVPIKPLISTPPVSSQPKVSTPVVKQGPVS 491
Cdd:pfam17823 266 AA----GTINMGDPHARRLSPAKHMPSD--TMARNPAAPMGAQAQGPIIQVSTDQPVHNTAGEPTPSPSNTTLEPNTPKS 339

                         250       260       270
                  ....*....|....*....|....*....|...
gi 2462519535 492 QSATQQP-VTADKQQGHEPVSPRSLQRSSQRSP 523
Cdd:pfam17823 340 VASTNLAvVTTTKAQAKEPSASPVPVLHTSMIP 372
PRP40 COG5104
Splicing factor [RNA processing and modification];
132-168 8.11e-04

Splicing factor [RNA processing and modification];


Pssm-ID: 227435 [Multi-domain]  Cd Length: 590  Bit Score: 42.37  E-value: 8.11e-04
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 2462519535 132 ADDWSEHISSSGKKYYYNCRTEVSQWEKPKEWLEREQ 168
Cdd:COG5104    14 RSEWEELKAPDGRIYYYNKRTGKSSWEKPKELLKGSE 50
PRP40 COG5104
Splicing factor [RNA processing and modification];
131-198 3.65e-03

Splicing factor [RNA processing and modification];


Pssm-ID: 227435 [Multi-domain]  Cd Length: 590  Bit Score: 40.45  E-value: 3.65e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462519535 131 SADDWSEHISSSGKKYYYNCRTEVSQWEKPKEW--LEREQRQKEA---------NKMAVNSFPKD---RDYRREVMQATA 196
Cdd:COG5104    54 DVDPWKECRTADGKVYYYNSITRESRWKIPPERkkVEPIAEQKHDersmiggngNDMAITDHETSepkYLLGRLMSQYGI 133


                  ..
gi 2462519535 197 TS 198
Cdd:COG5104   134 TS 135
 
Name Accession Description Interval E-value
WW pfam00397
WW domain; The WW domain is a protein module with two highly conserved tryptophans that binds ...
 133-160 3.94e-09

WW domain; The WW domain is a protein module with two highly conserved tryptophans that binds proline-rich peptide motifs in vitro.


Pssm-ID: 459800 [Multi-domain]  Cd Length: 30  Bit Score: 52.12  E-value: 3.94e-09
                          10        20
                  ....*....|....*....|....*...
gi 2462519535 133 DDWSEHISSSGKKYYYNCRTEVSQWEKP 160
Cdd:pfam00397   3 PGWEERWDPDGRVYYYNHETGETQWEKP 30
WW cd00201
Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; ...
 133-162 1.45e-08

Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other peptide recognition proteins such as antibodies and receptors; WW domains have a single groove formed by a conserved Trp and Tyr which recognizes a pair of residues of the sequence X-Pro; variable loops and neighboring domains confer specificity in this domain; there are five distinct groups based on binding: 1) PPXY motifs 2) the PPLP motif; 3) PGM motifs; 4) PSP or PTP motifs; 5) PR motifs.


Pssm-ID: 238122 [Multi-domain]  Cd Length: 31  Bit Score: 50.60  E-value: 1.45e-08
                          10        20        30
                  ....*....|....*....|....*....|
gi 2462519535 133 DDWSEHISSSGKKYYYNCRTEVSQWEKPKE 162
Cdd:cd00201     2 PGWEERWDPDGRVYYYNHNTKETQWEDPRE 31
PHA03247 PHA03247
large tegument protein UL36; Provisional
 235-527 5.44e-07

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 53.40  E-value: 5.44e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462519535  235 PRAETHSSSTPVQHPIKPvvhPTATPSTVPSSPFTLQSDHQPKKSFDANGASTLSKLPTPTSSVPAQKTERKESTSGDKP 314
Cdd:PHA03247  2609 RGPAPPSPLPPDTHAPDP---PPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRR 2685

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462519535  315 VSHSCTTPSTSSASglNPTSAPPTSASAvPVSPVPQSPIPPLLQDPNLLRQLLPALQATLQLNNSNVDISKINEVLTAAV 394
Cdd:PHA03247  2686 RAARPTVGSLTSLA--DPPPPPPTPEPA-PHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPT 2762

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462519535  395 TQASLQSIIHKFLTAGPSAfNITSLISQAAQLSTQAQPSNQSPMSLTSDASSPRSYVSPRIS-----TPQTNTVPIKPLI 469
Cdd:PHA03247  2763 TAGPPAPAPPAAPAAGPPR-RLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASpagplPPPTSAQPTAPPP 2841

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 2462519535  470 STPPVSSQPKVSTPVVKQGPVSQSA-TQQPVTADKQQGHEPVSpRSLQRSSQRSPSPGP 527
Cdd:PHA03247  2842 PPGPPPPSLPLGGSVAPGGDVRRRPpSRSPAAKPAAPARPPVR-RLARPAVSRSTESFA 2899
WW smart00456
Domain with 2 conserved Trp (W) residues; Also known as the WWP or rsp5 domain. Binds ...
 135-162 1.25e-06

Domain with 2 conserved Trp (W) residues; Also known as the WWP or rsp5 domain. Binds proline-rich polypeptides.


Pssm-ID: 197736 [Multi-domain]  Cd Length: 33  Bit Score: 45.28  E-value: 1.25e-06
                           10        20
                   ....*....|....*....|....*...
gi 2462519535  135 WSEHISSSGKKYYYNCRTEVSQWEKPKE 162
Cdd:smart00456   6 WEERKDPDGRPYYYNHETKETQWEKPRE 33
PHA03247 PHA03247
large tegument protein UL36; Provisional
 234-561 1.41e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 51.86  E-value: 1.41e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462519535  234 LPRAETHSSSTPVQHPIKPVVHPTATPSTVPSSPFTLQSDHQPKKSFDANGASTLSKLPTPTSSVPAQKTERKESTSGDK 313
Cdd:PHA03247  2721 LPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPS 2800

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462519535  314 PVSHSCTTPSTSSASGLNPTSAPPTSASAVPVSPVPQSPIPPLlqdpnllrqllPALQATLQLNNSNV---DISKINEVL 390
Cdd:PHA03247  2801 PWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPP-----------GPPPPSLPLGGSVApggDVRRRPPSR 2869

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462519535  391 TAAVTQASlqsiihkfltagPSAFNITSLISQAAQLSTQ--AQPSNQSPMSLTSDASSPrsyvspristPQTNTVPIKPL 468
Cdd:PHA03247  2870 SPAAKPAA------------PARPPVRRLARPAVSRSTEsfALPPDQPERPPQPQAPPP----------PQPQPQPPPPP 2927

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462519535  469 ISTPPVSSQPKVSTPVVKQGPVSQSATQQPVTADKQQGHepVSPRSLQRSSQRSPSPGPNHTSNSSnasnATVVPQNSSA 548
Cdd:PHA03247  2928 QPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGA--LVPGRVAVPRFRVPQPAPSREAPAS----STPPLTGHSL 3001

                          330
                   ....*....|...
gi 2462519535  549 RSTCSLTPALAAH 561
Cdd:PHA03247  3002 SRVSSWASSLALH 3014
DUF5585 pfam17823
Family of unknown function (DUF5585); This is a family of unknown function found in chordata.
 252-523 3.00e-04

Family of unknown function (DUF5585); This is a family of unknown function found in chordata.


Pssm-ID: 465521 [Multi-domain]  Cd Length: 506  Bit Score: 43.80  E-value: 3.00e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462519535 252 PVVHPTATPSTVPSSpFTLQSDHQPKKSFDANGASTLSklpTPTSSVPAQKTERKESTSGDKPVSHSCTTPSTSSASGLN 331
Cdd:pfam17823 115 LAAAASSSPSSAAQS-LPAAIAALPSEAFSAPRAAACR---ANASAAPRAAIAAASAPHAASPAPRTAASSTTAASSTTA 190

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462519535 332 PTSAPPTSASAVPVSPVPQSPIppllqDPNLLRQLLPALQATLQLNNSNVDISKINEVLTAAVTQASLQSIIHKFLTAGP 411
Cdd:pfam17823 191 ASSAPTTAASSAPATLTPARGI-----STAATATGHPAAGTALAAVGNSSPAAGTVTAAVGTVTPAALATLAAAAGTVAS 265

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462519535 412 SAfnitSLISQAAQLSTQAQPSNQSPMSltSDASSPRSYVSPRISTPQTNTVPIKPLISTPPVSSQPKVSTPVVKQGPVS 491
Cdd:pfam17823 266 AA----GTINMGDPHARRLSPAKHMPSD--TMARNPAAPMGAQAQGPIIQVSTDQPVHNTAGEPTPSPSNTTLEPNTPKS 339

                         250       260       270
                  ....*....|....*....|....*....|...
gi 2462519535 492 QSATQQP-VTADKQQGHEPVSPRSLQRSSQRSP 523
Cdd:pfam17823 340 VASTNLAvVTTTKAQAKEPSASPVPVLHTSMIP 372
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 427-589 5.13e-04

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 43.54  E-value: 5.13e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462519535  427 STQAQPSNQSPMSLTSDASSPRSYVSPRISTPQTNTVPIKPLISTPPV-SSQPKVSTPVVKQGPVSQSATQQPVTADKQQ 505
Cdd:PRK10263   299 ATQPEYDEYDPLLNGAPITEPVAVAAAATTATQSWAAPVEPVTQTPPVaSVDVPPAQPTVAWQPVPGPQTGEPVIAPAPE 378

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462519535  506 GHEPVSPRSLQRSSQRSPSPGPNHTSNSSNASNATVVPQNSSARSTCSlTPALAAHFSENLIKHVQGWPAdHAEKQASRL 585
Cdd:PRK10263   379 GYPQQSQYAQPAVQYNEPLQQPVQPQQPYYAPAAEQPAQQPYYAPAPE-QPAQQPYYAPAPEQPVAGNAW-QAEEQQSTF 456


                   ....
gi 2462519535  586 REEA 589
Cdd:PRK10263   457 APQS 460
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 259-556 5.83e-04

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 42.98  E-value: 5.83e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462519535 259 TPSTVPSSPFTLQSDHQPKKSFDANGASTLSKLPTPTSSVPAQKTE---RKESTSGDKPVSH--------SCTTPSTSSA 327
Cdd:pfam05109 392 TVSGLGTAPKTLIITRTATNATTTTHKVIFSKAPESTTTSPTLNTTgfaAPNTTTGLPSSTHvptnltapASTGPTVSTA 471

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462519535 328 SGLNPTSAPPTSAsAVPVSPVPqSPippllQDPNLLRQLLPALQATLQLNNSNVDISKINEVLTAAVTQASLQSI----- 402
Cdd:pfam05109 472 DVTSPTPAGTTSG-ASPVTPSP-SP-----RDNGTESKAPDMTSPTSAVTTPTPNATSPTPAVTTPTPNATSPTLgktsp 544

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462519535 403 IHKFLTAGPSAFNITSLISQAAQLSTQAQPSNQSPMSLTSDASSPRSYVSPRISTPQTNTV--PIKPLISTPPVSSQPKV 480
Cdd:pfam05109 545 TSAVTTPTPNATSPTPAVTTPTPNATIPTLGKTSPTSAVTTPTPNATSPTVGETSPQANTTnhTLGGTSSTPVVTSPPKN 624

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462519535 481 STPVVKQG---------------PVSQSATQQPVTADKQQGHEP---------------VSP--RSLQRSSQRSPSPGPN 528
Cdd:pfam05109 625 ATSAVTTGqhnitssstssmslrPSSISETLSPSTSDNSTSHMPlltsahptggenitqVTPasTSTHHVSTSSPAPRPG 704

                         330       340
                  ....*....|....*....|....*...
gi 2462519535 529 HTSNSSNASNATVVPQNSSARSTCSLTP 556
Cdd:pfam05109 705 TTSQASGPGNSSTSTKPGEVNVTKGTPP 732
PRP40 COG5104
Splicing factor [RNA processing and modification];
132-168 8.11e-04

Splicing factor [RNA processing and modification];


Pssm-ID: 227435 [Multi-domain]  Cd Length: 590  Bit Score: 42.37  E-value: 8.11e-04
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 2462519535 132 ADDWSEHISSSGKKYYYNCRTEVSQWEKPKEWLEREQ 168
Cdd:COG5104    14 RSEWEELKAPDGRIYYYNKRTGKSSWEKPKELLKGSE 50
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 234-539 1.35e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 42.06  E-value: 1.35e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462519535 234 LPRAETHSSSTPVQHPIKpvVHPTATPSTVPSSPFTLQSDhqpkksfdaNGASTLSKLPTPTSSVPAQkterkeSTSGDK 313
Cdd:pfam03154 266 LPQPSLHGQMPPMPHSLQ--TGPSHMQHPVPPQPFPLTPQ---------SSQSQVPPGPSPAAPGQSQ------QRIHTP 328

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462519535 314 PVSHSCTTPSTSSASGLNPTSAPPTSASAVPVSPVPQSPIPPLLQDPNLLRQLLP-ALQATLQLNNSNVDISKINEVLTA 392
Cdd:pfam03154 329 PSQSQLQSQQPPREQPLPPAPLSMPHIKPPPTTPIPQLPNPQSHKHPPHLSGPSPfQMNSNLPPPPALKPLSSLSTHHPP 408

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462519535 393 AVTQASLQSIIHKFLTAGPSAFNITSLISQAAQLSTQAQPSNQSPMSLTSDASSPRSYVSPRISTPQTNTVPIKPLISTP 472
Cdd:pfam03154 409 SAHPPPLQLMPQSQQLPPPPAQPPVLTQSQSLPPPAASHPPTSGLHQVPSQSPFPQHPFVPGGPPPITPPSGPPTSTSSA 488

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2462519535 473 PVSSQPKVSTPVVKQGPV--SQSATQQPVTADKQQGHEPVSPRSlQRSSQRSPSPGPNHTSNSSNASNA 539
Cdd:pfam03154 489 MPGIQPPSSASVSSSGPVpaAVSCPLPPVQIKEEALDEAEEPES-PPPPPRSPSPEPTVVNTPSHASQS 556
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 234-549 1.52e-03

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 41.83  E-value: 1.52e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462519535 234 LPRAETHSSSTPVQHPIKPVVHPTATPSTVPSSPFTlqsdhqPKKSFDANGasTLSKLPTPTSSVPAQKTERKESTSGDK 313
Cdd:pfam05109 454 VPTNLTAPASTGPTVSTADVTSPTPAGTTSGASPVT------PSPSPRDNG--TESKAPDMTSPTSAVTTPTPNATSPTP 525

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462519535 314 PVSHSCTTPSTSSASGLNPTSA----PPTSASAVP--VSPVPQSPIPPLLQDPNLLRQLLPALQATL--------QLNNS 379
Cdd:pfam05109 526 AVTTPTPNATSPTLGKTSPTSAvttpTPNATSPTPavTTPTPNATIPTLGKTSPTSAVTTPTPNATSptvgetspQANTT 605

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462519535 380 NVDISKINEV---------LTAAVT--QASLQSIIHKFLTAGPSAFN-----------------ITSLISQAAQLSTQAQ 431
Cdd:pfam05109 606 NHTLGGTSSTpvvtsppknATSAVTtgQHNITSSSTSSMSLRPSSISetlspstsdnstshmplLTSAHPTGGENITQVT 685

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462519535 432 PSNQSPMSLTSDASSPRSYVSPRISTPQTNTVPIKPLISTPPVSSQPKVSTPvvKQGPVSQSATQQPVT-----ADKQQG 506
Cdd:pfam05109 686 PASTSTHHVSTSSPAPRPGTTSQASGPGNSSTSTKPGEVNVTKGTPPKNATS--PQAPSGQKTAVPTVTstggkANSTTG 763

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|...
gi 2462519535 507 HEPVSPRSLQRSSQRSPSPGPNHTSNSSNASNATVVPQNSSAR 549
Cdd:pfam05109 764 GKHTTGHGARTSTEPTTDYGGDSTTPRTRYNATTYLPPSTSSK 806
PRP40 COG5104
Splicing factor [RNA processing and modification];
131-198 3.65e-03

Splicing factor [RNA processing and modification];


Pssm-ID: 227435 [Multi-domain]  Cd Length: 590  Bit Score: 40.45  E-value: 3.65e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462519535 131 SADDWSEHISSSGKKYYYNCRTEVSQWEKPKEW--LEREQRQKEA---------NKMAVNSFPKD---RDYRREVMQATA 196
Cdd:COG5104    54 DVDPWKECRTADGKVYYYNSITRESRWKIPPERkkVEPIAEQKHDersmiggngNDMAITDHETSepkYLLGRLMSQYGI 133


                  ..
gi 2462519535 197 TS 198
Cdd:COG5104   134 TS 135
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 233-561 6.96e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 39.77  E-value: 6.96e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462519535  233 RLPRAETHSSSTPVQHPIKPVVHPTATPSTVPSSPFTLQSDHQPKKSFDA---NGASTLSKLPTPTSSVPAQKTERKEST 309
Cdd:PHA03307    66 EPPTGPPPGPGTEAPANESRSTPTWSLSTLAPASPAREGSPTPPGPSSPDpppPTPPPASPPPSPAPDLSEMLRPVGSPG 145

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462519535  310 SGDKPVSHSCTTPSTSSASGLnPTSAPPTSASAVPVS----PVPQSPIPPLLQDPNLLRQLLPALQATLQLNNSNVDISK 385
Cdd:PHA03307   146 PPPAASPPAAGASPAAVASDA-ASSRQAALPLSSPEEtaraPSSPPAEPPPSTPPAAASPRPPRRSSPISASASSPAPAP 224

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462519535  386 I-NEVLTAAVTQASLQSIIHKFLTAGPSAFNITSLISQAAQLSTQAQPSNQSPMSLTSDASSPRSyvSPRISTPqtntvp 464
Cdd:PHA03307   225 GrSAADDAGASSSDSSSSESSGCGWGPENECPLPRPAPITLPTRIWEASGWNGPSSRPGPASSSS--SPRERSP------ 296

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462519535  465 iKPLISTPPVSSQPKVSTPVVKQGPVSQSATQQPVTADKQQGHEPVSP-RSLQRSSQRSPSPGPNHTSNSSNASNATVVP 543
Cdd:PHA03307   297 -SPSPSSPGSGPAPSSPRASSSSSSSRESSSSSTSSSSESSRGAAVSPgPSPSRSPSPSRPPPPADPSSPRKRPRPSRAP 375

                          330       340
                   ....*....|....*....|.
gi 2462519535  544 QN---SSARSTCSLTPALAAH 561
Cdd:PHA03307   376 SSpaaSAGRPTRRRARAAVAG 396
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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