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Conserved domains on  [gi|2462520894|ref|XP_054222667|]
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zinc finger protein 33A isoform X2 [Homo sapiens]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 11472214)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940
SCOP:  4003583

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
360-720 5.05e-10

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 62.41  E-value: 5.05e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462520894 360 KPYECYECGKSFRVTSHLKVHQRTHTGEKPFECL--ECGKSFSEKSNLTQHQRIHIGDKSYECNACGKTFYHKsllTRHQ 437
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSK---ASSS 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462520894 438 IIHtgwkpyecyECGKTFCLKSDLTVHQRTHTGQKPFACPECGKFFSHKSTLSQHYRTHTGEK-------PYECHECGKI 510
Cdd:COG5048   109 SLS---------SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPqsnslhpPLPANSLSKD 179

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462520894 511 FYNKSYLTKHNRTHTGEKPYECNECGKAFYQKSQLTQHQRIHIGEKPYKCNECGkAFCHKSALI---------------- 574
Cdd:COG5048   180 PSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNS-QLSPKSLLSqspsslsssdssssas 258

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462520894 575 ----------VHQRTHTQE----------KPYKCNECGKSFCVKSGLIFHERK--HTGE--KPYECNE--CGKFFRHKSS 628
Cdd:COG5048   259 esprsslptaSSQSSSPNEsdsssekgfsLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDA 338

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462520894 629 LTVHHRAHTG-----EKSCQCN--ECGKIFYRKSELAQHQRSHTGEKPYEC--NTCRKTFSQKSNLIVHQRRHIGENLMN 699
Cdd:COG5048   339 LKRHILLHTSispakEKLLNSSskFSPLLNNEPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYN 418

                         410       420
                  ....*....|....*....|.
gi 2462520894 700 EMDIRNFQPQVSLHNASEYSH 720
Cdd:COG5048   419 CKNPPCSKSFNRHYNLIPHKK 439
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
63-437 1.14e-05

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 48.54  E-value: 1.14e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462520894  63 CDSCGMSFNTVSELVISKINYLGKKSDEFNACGK------LLLNIKHDETHTQEKNEVLKNRN-----TLSHHEETLQHE 131
Cdd:COG5048    36 CPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCdksfsrPLELSRHLRTHHNNPSDLNSKSLplsnsKASSSSLSSSSS 115

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462520894 132 KIQTLEHNFEYSICQET---LLEKAVFNTQKRENAE--ENNCDYNEFGRTL---------------CDSSSLLFHQISPS 191
Cdd:COG5048   116 NSNDNNLLSSHSLPPSSrdpQLPDLLSISNLRNNPLpgNNSSSVNTPQSNSlhpplpanslskdpsSNLSLLISSNVSTS 195

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462520894 192 RDNHYEFSDCEKFLCVKSTLSKPHGVSM-KHYDCGESGNNFRRKLCLSHLQKGDKGEKHFECNECGKAFWEKSHLTRHQR 270
Cdd:COG5048   196 IPSSSENSPLSSSYSIPSSSSDQNLENSsSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQSSSP 275

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462520894 271 VHTG-------QKPFQCNECEKAFWDKSNLTKHQRS--HTGE--KPFECNE--CGKAFSHKSALTLHQRTHTGEKPYQCN 337
Cdd:COG5048   276 NESDsssekgfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEK 355

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462520894 338 ACGKTF--------CQKSDLTKHQRTHTGLKPYECYECGKSFRVTSH-LKVHQRTHTGEKP--FECLECGKSFSEKSNLT 406
Cdd:COG5048   356 LLNSSSkfspllnnEPPQSLQQYKDLKNDKKSETLSNSCIRNFKRDSnLSLHIITHLSFRPynCKNPPCSKSFNRHYNLI 435

                         410       420       430
                  ....*....|....*....|....*....|.
gi 2462520894 407 QHQRIHIGDKSYECNACGKTFYHKSLLTRHQ 437
Cdd:COG5048   436 PHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
360-720 5.05e-10

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 62.41  E-value: 5.05e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462520894 360 KPYECYECGKSFRVTSHLKVHQRTHTGEKPFECL--ECGKSFSEKSNLTQHQRIHIGDKSYECNACGKTFYHKsllTRHQ 437
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSK---ASSS 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462520894 438 IIHtgwkpyecyECGKTFCLKSDLTVHQRTHTGQKPFACPECGKFFSHKSTLSQHYRTHTGEK-------PYECHECGKI 510
Cdd:COG5048   109 SLS---------SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPqsnslhpPLPANSLSKD 179

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462520894 511 FYNKSYLTKHNRTHTGEKPYECNECGKAFYQKSQLTQHQRIHIGEKPYKCNECGkAFCHKSALI---------------- 574
Cdd:COG5048   180 PSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNS-QLSPKSLLSqspsslsssdssssas 258

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462520894 575 ----------VHQRTHTQE----------KPYKCNECGKSFCVKSGLIFHERK--HTGE--KPYECNE--CGKFFRHKSS 628
Cdd:COG5048   259 esprsslptaSSQSSSPNEsdsssekgfsLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDA 338

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462520894 629 LTVHHRAHTG-----EKSCQCN--ECGKIFYRKSELAQHQRSHTGEKPYEC--NTCRKTFSQKSNLIVHQRRHIGENLMN 699
Cdd:COG5048   339 LKRHILLHTSispakEKLLNSSskFSPLLNNEPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYN 418

                         410       420
                  ....*....|....*....|.
gi 2462520894 700 EMDIRNFQPQVSLHNASEYSH 720
Cdd:COG5048   419 CKNPPCSKSFNRHYNLIPHKK 439
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
63-437 1.14e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 48.54  E-value: 1.14e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462520894  63 CDSCGMSFNTVSELVISKINYLGKKSDEFNACGK------LLLNIKHDETHTQEKNEVLKNRN-----TLSHHEETLQHE 131
Cdd:COG5048    36 CPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCdksfsrPLELSRHLRTHHNNPSDLNSKSLplsnsKASSSSLSSSSS 115

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462520894 132 KIQTLEHNFEYSICQET---LLEKAVFNTQKRENAE--ENNCDYNEFGRTL---------------CDSSSLLFHQISPS 191
Cdd:COG5048   116 NSNDNNLLSSHSLPPSSrdpQLPDLLSISNLRNNPLpgNNSSSVNTPQSNSlhpplpanslskdpsSNLSLLISSNVSTS 195

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462520894 192 RDNHYEFSDCEKFLCVKSTLSKPHGVSM-KHYDCGESGNNFRRKLCLSHLQKGDKGEKHFECNECGKAFWEKSHLTRHQR 270
Cdd:COG5048   196 IPSSSENSPLSSSYSIPSSSSDQNLENSsSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQSSSP 275

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462520894 271 VHTG-------QKPFQCNECEKAFWDKSNLTKHQRS--HTGE--KPFECNE--CGKAFSHKSALTLHQRTHTGEKPYQCN 337
Cdd:COG5048   276 NESDsssekgfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEK 355

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462520894 338 ACGKTF--------CQKSDLTKHQRTHTGLKPYECYECGKSFRVTSH-LKVHQRTHTGEKP--FECLECGKSFSEKSNLT 406
Cdd:COG5048   356 LLNSSSkfspllnnEPPQSLQQYKDLKNDKKSETLSNSCIRNFKRDSnLSLHIITHLSFRPynCKNPPCSKSFNRHYNLI 435

                         410       420       430
                  ....*....|....*....|....*....|.
gi 2462520894 407 QHQRIHIGDKSYECNACGKTFYHKSLLTRHQ 437
Cdd:COG5048   436 PHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
zf-H2C2_2 pfam13465
Zinc-finger double domain;
292-317 5.76e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 5.76e-04
                          10        20
                  ....*....|....*....|....*.
gi 2462520894 292 NLTKHQRSHTGEKPFECNECGKAFSH 317
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
376-400 8.95e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 8.95e-04
                          10        20
                  ....*....|....*....|....*
gi 2462520894 376 HLKVHQRTHTGEKPFECLECGKSFS 400
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
360-720 5.05e-10

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 62.41  E-value: 5.05e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462520894 360 KPYECYECGKSFRVTSHLKVHQRTHTGEKPFECL--ECGKSFSEKSNLTQHQRIHIGDKSYECNACGKTFYHKsllTRHQ 437
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSK---ASSS 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462520894 438 IIHtgwkpyecyECGKTFCLKSDLTVHQRTHTGQKPFACPECGKFFSHKSTLSQHYRTHTGEK-------PYECHECGKI 510
Cdd:COG5048   109 SLS---------SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPqsnslhpPLPANSLSKD 179

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462520894 511 FYNKSYLTKHNRTHTGEKPYECNECGKAFYQKSQLTQHQRIHIGEKPYKCNECGkAFCHKSALI---------------- 574
Cdd:COG5048   180 PSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNS-QLSPKSLLSqspsslsssdssssas 258

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462520894 575 ----------VHQRTHTQE----------KPYKCNECGKSFCVKSGLIFHERK--HTGE--KPYECNE--CGKFFRHKSS 628
Cdd:COG5048   259 esprsslptaSSQSSSPNEsdsssekgfsLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDA 338

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462520894 629 LTVHHRAHTG-----EKSCQCN--ECGKIFYRKSELAQHQRSHTGEKPYEC--NTCRKTFSQKSNLIVHQRRHIGENLMN 699
Cdd:COG5048   339 LKRHILLHTSispakEKLLNSSskFSPLLNNEPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYN 418

                         410       420
                  ....*....|....*....|.
gi 2462520894 700 EMDIRNFQPQVSLHNASEYSH 720
Cdd:COG5048   419 CKNPPCSKSFNRHYNLIPHKK 439
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
250-595 1.71e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 60.86  E-value: 1.71e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462520894 250 FECNECGKAFWEKSHLTRHQRVHTGQKPFQCN--ECEKAFWDKSNLTKHQRSHTGEKPFECNECGKAFSHKSALTLHQRT 327
Cdd:COG5048    34 DSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLSSS 113

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462520894 328 HTGE-KPYQCNACGKTFCQKSDLTKHQRTHTGLKPYECYECGKSFRVTS----------------------HLKVHQRTH 384
Cdd:COG5048   114 SSNSnDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPqsnslhpplpanslskdpssnlSLLISSNVS 193

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462520894 385 TGEKPFECLECGKSFSEKSNLTQHQRIHIGDKSYECNACG------------------------KTFYHKSLLTRHQIIH 440
Cdd:COG5048   194 TSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSqlspksllsqspsslsssdssssaSESPRSSLPTASSQSS 273

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462520894 441 TGW-----------KPYECYECGKTFCLKSDLTVHQRT--HTGQ--KPFACPE--CGKFFSHKSTLSQHYRTHTGEKPYE 503
Cdd:COG5048   274 SPNesdsssekgfsLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAK 353

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462520894 504 CHECGKIFYNKSYLTK-------HNRTHTGEKPYEC--NECGKAFYQKSQLTQHQRIHIGEKP--YKCNECGKAFCHKSA 572
Cdd:COG5048   354 EKLLNSSSKFSPLLNNeppqslqQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYN 433

                         410       420
                  ....*....|....*....|...
gi 2462520894 573 LIVHQRTHTQEKPYKCNECGKSF 595
Cdd:COG5048   434 LIPHKKIHTNHAPLLCSILKSFR 456
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
63-437 1.14e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 48.54  E-value: 1.14e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462520894  63 CDSCGMSFNTVSELVISKINYLGKKSDEFNACGK------LLLNIKHDETHTQEKNEVLKNRN-----TLSHHEETLQHE 131
Cdd:COG5048    36 CPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCdksfsrPLELSRHLRTHHNNPSDLNSKSLplsnsKASSSSLSSSSS 115

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462520894 132 KIQTLEHNFEYSICQET---LLEKAVFNTQKRENAE--ENNCDYNEFGRTL---------------CDSSSLLFHQISPS 191
Cdd:COG5048   116 NSNDNNLLSSHSLPPSSrdpQLPDLLSISNLRNNPLpgNNSSSVNTPQSNSlhpplpanslskdpsSNLSLLISSNVSTS 195

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462520894 192 RDNHYEFSDCEKFLCVKSTLSKPHGVSM-KHYDCGESGNNFRRKLCLSHLQKGDKGEKHFECNECGKAFWEKSHLTRHQR 270
Cdd:COG5048   196 IPSSSENSPLSSSYSIPSSSSDQNLENSsSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQSSSP 275

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462520894 271 VHTG-------QKPFQCNECEKAFWDKSNLTKHQRS--HTGE--KPFECNE--CGKAFSHKSALTLHQRTHTGEKPYQCN 337
Cdd:COG5048   276 NESDsssekgfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEK 355

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462520894 338 ACGKTF--------CQKSDLTKHQRTHTGLKPYECYECGKSFRVTSH-LKVHQRTHTGEKP--FECLECGKSFSEKSNLT 406
Cdd:COG5048   356 LLNSSSkfspllnnEPPQSLQQYKDLKNDKKSETLSNSCIRNFKRDSnLSLHIITHLSFRPynCKNPPCSKSFNRHYNLI 435

                         410       420       430
                  ....*....|....*....|....*....|.
gi 2462520894 407 QHQRIHIGDKSYECNACGKTFYHKSLLTRHQ 437
Cdd:COG5048   436 PHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
zf-H2C2_2 pfam13465
Zinc-finger double domain;
292-317 5.76e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 5.76e-04
                          10        20
                  ....*....|....*....|....*.
gi 2462520894 292 NLTKHQRSHTGEKPFECNECGKAFSH 317
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
376-400 8.95e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 8.95e-04
                          10        20
                  ....*....|....*....|....*
gi 2462520894 376 HLKVHQRTHTGEKPFECLECGKSFS 400
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
264-288 1.87e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.87e-03
                          10        20
                  ....*....|....*....|....*
gi 2462520894 264 HLTRHQRVHTGQKPFQCNECEKAFW 288
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
656-681 3.12e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 3.12e-03
                          10        20
                  ....*....|....*....|....*.
gi 2462520894 656 ELAQHQRSHTGEKPYECNTCRKTFSQ 681
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
460-485 3.44e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 3.44e-03
                          10        20
                  ....*....|....*....|....*.
gi 2462520894 460 DLTVHQRTHTGQKPFACPECGKFFSH 485
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
516-541 3.68e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 3.68e-03
                          10        20
                  ....*....|....*....|....*.
gi 2462520894 516 YLTKHNRTHTGEKPYECNECGKAFYQ 541
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
545-567 4.14e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 4.14e-03
                          10        20
                  ....*....|....*....|...
gi 2462520894 545 LTQHQRIHIGEKPYKCNECGKAF 567
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
572-595 4.35e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 4.35e-03
                          10        20
                  ....*....|....*....|....
gi 2462520894 572 ALIVHQRTHTQEKPYKCNECGKSF 595
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
348-371 7.26e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 7.26e-03
                          10        20
                  ....*....|....*....|....
gi 2462520894 348 DLTKHQRTHTGLKPYECYECGKSF 371
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 334-356 7.80e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.58  E-value: 7.80e-03
                          10        20
                  ....*....|....*....|...
gi 2462520894 334 YQCNACGKTFCQKSDLTKHQRTH 356
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 558-580 8.69e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.20  E-value: 8.69e-03
                          10        20
                  ....*....|....*....|...
gi 2462520894 558 YKCNECGKAFCHKSALIVHQRTH 580
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
489-511 9.28e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 9.28e-03
                          10        20
                  ....*....|....*....|...
gi 2462520894 489 LSQHYRTHTGEKPYECHECGKIF 511
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
601-625 9.94e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 9.94e-03
                          10        20
                  ....*....|....*....|....*
gi 2462520894 601 LIFHERKHTGEKPYECNECGKFFRH 625
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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