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Conserved domains on  [gi|2462527634|ref|XP_054225942|]
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mitochondrial glutamate carrier 1 isoform X1 [Homo sapiens]

Protein Classification

solute carrier family 25 protein( domain architecture ID 13506698)

solute carrier 25 family (SLC25) protein which transfers molecules across the membranes of organelles, usually mitochondria

Gene Ontology:  GO:0016020|GO:1990542
TCDB:  2.A.29

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Mito_carr pfam00153
Mitochondrial carrier protein;
4-98 3.68e-23

Mitochondrial carrier protein;


:

Pssm-ID: 395101 [Multi-domain]  Cd Length: 96  Bit Score: 91.56  E-value: 3.68e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462527634   4 KQISLPAKLINGGIAGLIGVTCVFPIDLAKTRLQNQ-QNGQRVYTSMSDCLIKTVRSEGYFGMYRGAAVNLTLVTPEKAI 82
Cdd:pfam00153   1 SELSFLASLLAGGIAGAIAVTVTYPLDVVKTRLQVQgGSGKSKGRGILDCFKKIYKEEGIRGLYKGLLPNLLRVAPAAAI 80
                          90
                  ....*....|....*.
gi 2462527634  83 KLAANDFFRHQLSKDG 98
Cdd:pfam00153  81 YFGTYETLKRLLLKKL 96
PTZ00169 super family cl36523
ADP/ATP transporter on adenylate translocase; Provisional
3-289 2.39e-17

ADP/ATP transporter on adenylate translocase; Provisional


The actual alignment was detected with superfamily member PTZ00169:

Pssm-ID: 240302 [Multi-domain]  Cd Length: 300  Bit Score: 80.97  E-value: 2.39e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462527634   3 DKQISLPAKLINGGIAGLIGVTCVFPIDLAKTRLQNQQNGQRV-------YTSMSDCLIKTVRSEGYFGMYRGAAVNLTL 75
Cdd:PTZ00169    2 DKKTNFATDFLMGGISAAISKTAVAPIERVKMLIQTQDSIPEIksgkvprYSGIVNCFRRVSKEQGVLSLWRGNTANVIR 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462527634  76 VTPEKAIKLAANDFFRHQLSKDGQKLTLLK----EMLAGCGAGTCQVIVTTPMEMLKIQL-QDAGRiAAQRKIlaaQGQL 150
Cdd:PTZ00169   82 YFPTQAFNFAFKDYFKNMFPKYNQKTDFWKffgvNILSGGLAGASSLLIVYPLDFARTRLaSDIGK-GGDREF---TGLF 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462527634 151 SAQGGAQpsveapaaprptatqltrdllRSRGIAGLYKGLGATLLRDVPFSVVYFPLFANLNQLGRPASEEKSPFY---- 226
Cdd:PTZ00169  158 DCLMKIS---------------------KQTGFLSLYQGFGVSVQGIIVYRGAYFGLYDSAKALLFGNDKNTNILYkwav 216
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2462527634 227 ---VSFLAGCVAGsaaavavnPCDVVKTRLQ--SLQRGVNEDTYSGILDCARKILRHEGPSAFLKGAY 289
Cdd:PTZ00169  217 aqtVTILAGLISY--------PFDTVRRRMMmmSGRKAKSEIQYTGTLDCWKKILKNEGLGGFFKGAW 276
 
Name Accession Description Interval E-value
Mito_carr pfam00153
Mitochondrial carrier protein;
4-98 3.68e-23

Mitochondrial carrier protein;


Pssm-ID: 395101 [Multi-domain]  Cd Length: 96  Bit Score: 91.56  E-value: 3.68e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462527634   4 KQISLPAKLINGGIAGLIGVTCVFPIDLAKTRLQNQ-QNGQRVYTSMSDCLIKTVRSEGYFGMYRGAAVNLTLVTPEKAI 82
Cdd:pfam00153   1 SELSFLASLLAGGIAGAIAVTVTYPLDVVKTRLQVQgGSGKSKGRGILDCFKKIYKEEGIRGLYKGLLPNLLRVAPAAAI 80
                          90
                  ....*....|....*.
gi 2462527634  83 KLAANDFFRHQLSKDG 98
Cdd:pfam00153  81 YFGTYETLKRLLLKKL 96
PTZ00169 PTZ00169
ADP/ATP transporter on adenylate translocase; Provisional
3-289 2.39e-17

ADP/ATP transporter on adenylate translocase; Provisional


Pssm-ID: 240302 [Multi-domain]  Cd Length: 300  Bit Score: 80.97  E-value: 2.39e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462527634   3 DKQISLPAKLINGGIAGLIGVTCVFPIDLAKTRLQNQQNGQRV-------YTSMSDCLIKTVRSEGYFGMYRGAAVNLTL 75
Cdd:PTZ00169    2 DKKTNFATDFLMGGISAAISKTAVAPIERVKMLIQTQDSIPEIksgkvprYSGIVNCFRRVSKEQGVLSLWRGNTANVIR 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462527634  76 VTPEKAIKLAANDFFRHQLSKDGQKLTLLK----EMLAGCGAGTCQVIVTTPMEMLKIQL-QDAGRiAAQRKIlaaQGQL 150
Cdd:PTZ00169   82 YFPTQAFNFAFKDYFKNMFPKYNQKTDFWKffgvNILSGGLAGASSLLIVYPLDFARTRLaSDIGK-GGDREF---TGLF 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462527634 151 SAQGGAQpsveapaaprptatqltrdllRSRGIAGLYKGLGATLLRDVPFSVVYFPLFANLNQLGRPASEEKSPFY---- 226
Cdd:PTZ00169  158 DCLMKIS---------------------KQTGFLSLYQGFGVSVQGIIVYRGAYFGLYDSAKALLFGNDKNTNILYkwav 216
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2462527634 227 ---VSFLAGCVAGsaaavavnPCDVVKTRLQ--SLQRGVNEDTYSGILDCARKILRHEGPSAFLKGAY 289
Cdd:PTZ00169  217 aqtVTILAGLISY--------PFDTVRRRMMmmSGRKAKSEIQYTGTLDCWKKILKNEGLGGFFKGAW 276
Mito_carr pfam00153
Mitochondrial carrier protein;
221-306 6.23e-14

Mitochondrial carrier protein;


Pssm-ID: 395101 [Multi-domain]  Cd Length: 96  Bit Score: 66.53  E-value: 6.23e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462527634 221 EKSPFYVSFLAGCVAGSAAAVAVNPCDVVKTRLQSlQRGVNEDTYSGILDCARKILRHEGPSAFLKGAYCRALVIAPLFG 300
Cdd:pfam00153   1 SELSFLASLLAGGIAGAIAVTVTYPLDVVKTRLQV-QGGSGKSKGRGILDCFKKIYKEEGIRGLYKGLLPNLLRVAPAAA 79

                  ....*.
gi 2462527634 301 IAQVVY 306
Cdd:pfam00153  80 IYFGTY 85
 
Name Accession Description Interval E-value
Mito_carr pfam00153
Mitochondrial carrier protein;
4-98 3.68e-23

Mitochondrial carrier protein;


Pssm-ID: 395101 [Multi-domain]  Cd Length: 96  Bit Score: 91.56  E-value: 3.68e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462527634   4 KQISLPAKLINGGIAGLIGVTCVFPIDLAKTRLQNQ-QNGQRVYTSMSDCLIKTVRSEGYFGMYRGAAVNLTLVTPEKAI 82
Cdd:pfam00153   1 SELSFLASLLAGGIAGAIAVTVTYPLDVVKTRLQVQgGSGKSKGRGILDCFKKIYKEEGIRGLYKGLLPNLLRVAPAAAI 80
                          90
                  ....*....|....*.
gi 2462527634  83 KLAANDFFRHQLSKDG 98
Cdd:pfam00153  81 YFGTYETLKRLLLKKL 96
PTZ00169 PTZ00169
ADP/ATP transporter on adenylate translocase; Provisional
3-289 2.39e-17

ADP/ATP transporter on adenylate translocase; Provisional


Pssm-ID: 240302 [Multi-domain]  Cd Length: 300  Bit Score: 80.97  E-value: 2.39e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462527634   3 DKQISLPAKLINGGIAGLIGVTCVFPIDLAKTRLQNQQNGQRV-------YTSMSDCLIKTVRSEGYFGMYRGAAVNLTL 75
Cdd:PTZ00169    2 DKKTNFATDFLMGGISAAISKTAVAPIERVKMLIQTQDSIPEIksgkvprYSGIVNCFRRVSKEQGVLSLWRGNTANVIR 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462527634  76 VTPEKAIKLAANDFFRHQLSKDGQKLTLLK----EMLAGCGAGTCQVIVTTPMEMLKIQL-QDAGRiAAQRKIlaaQGQL 150
Cdd:PTZ00169   82 YFPTQAFNFAFKDYFKNMFPKYNQKTDFWKffgvNILSGGLAGASSLLIVYPLDFARTRLaSDIGK-GGDREF---TGLF 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462527634 151 SAQGGAQpsveapaaprptatqltrdllRSRGIAGLYKGLGATLLRDVPFSVVYFPLFANLNQLGRPASEEKSPFY---- 226
Cdd:PTZ00169  158 DCLMKIS---------------------KQTGFLSLYQGFGVSVQGIIVYRGAYFGLYDSAKALLFGNDKNTNILYkwav 216
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2462527634 227 ---VSFLAGCVAGsaaavavnPCDVVKTRLQ--SLQRGVNEDTYSGILDCARKILRHEGPSAFLKGAY 289
Cdd:PTZ00169  217 aqtVTILAGLISY--------PFDTVRRRMMmmSGRKAKSEIQYTGTLDCWKKILKNEGLGGFFKGAW 276
Mito_carr pfam00153
Mitochondrial carrier protein;
221-306 6.23e-14

Mitochondrial carrier protein;


Pssm-ID: 395101 [Multi-domain]  Cd Length: 96  Bit Score: 66.53  E-value: 6.23e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462527634 221 EKSPFYVSFLAGCVAGSAAAVAVNPCDVVKTRLQSlQRGVNEDTYSGILDCARKILRHEGPSAFLKGAYCRALVIAPLFG 300
Cdd:pfam00153   1 SELSFLASLLAGGIAGAIAVTVTYPLDVVKTRLQV-QGGSGKSKGRGILDCFKKIYKEEGIRGLYKGLLPNLLRVAPAAA 79

                  ....*.
gi 2462527634 301 IAQVVY 306
Cdd:pfam00153  80 IYFGTY 85
Mito_carr pfam00153
Mitochondrial carrier protein;
99-208 8.25e-14

Mitochondrial carrier protein;


Pssm-ID: 395101 [Multi-domain]  Cd Length: 96  Bit Score: 66.14  E-value: 8.25e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462527634  99 QKLTLLKEMLAGCGAGTCQVIVTTPMEMLKIQLQDAGRIAAQRKILAAQGqlsaqggaqpsveapaaprptatqlTRDLL 178
Cdd:pfam00153   1 SELSFLASLLAGGIAGAIAVTVTYPLDVVKTRLQVQGGSGKSKGRGILDC-------------------------FKKIY 55
                          90       100       110
                  ....*....|....*....|....*....|
gi 2462527634 179 RSRGIAGLYKGLGATLLRDVPFSVVYFPLF 208
Cdd:pfam00153  56 KEEGIRGLYKGLLPNLLRVAPAAAIYFGTY 85
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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