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Conserved domains on  [gi|2462534232|ref|XP_054229124|]
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zinc finger protein 140 isoform X4 [Homo sapiens]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 11472214)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940
SCOP:  4003583

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
89-382 2.02e-11

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 65.10  E-value: 2.02e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462534232  89 RPYGCHECGKTFGRRFSLVLHQRTHTGEKPYAC--KECGKTFSQISNLVKHQMIHTGKKPHECKDCNKTFSYLSFLIE-- 164
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSls 111
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462534232 165 -----------------HQRTHTGEKPYECTEC--GKAFSRASNLTRHQRIHIGKKQYICR---KCGKAFSSGSELIRHQ 222
Cdd:COG5048   112 ssssnsndnnllsshslPPSSRDPQLPDLLSISnlRNNPLPGNNSSSVNTPQSNSLHPPLPansLSKDPSSNLSLLISSN 191
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462534232 223 ITHTGEKPYECIECGKaFRRFSHLTRHQSIHTTKTPYECNECRKAFRCHSFLIKHQRIHAGEKLYECDECGKVFTWHASL 302
Cdd:COG5048   192 VSTSIPSSSENSPLSS-SYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASS 270
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462534232 303 IQHTKSHTGE-------KPYACAECDKAFSRSFSLILHQRT--HTGE--KPYVCKV--CNKSFSWSSNLAKHQRTHTLDN 369
Cdd:COG5048   271 QSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSIS 350
                         330
                  ....*....|...
gi 2462534232 370 PYEYENSFNYHSF 382
Cdd:COG5048   351 PAKEKLLNSSSKF 363
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
89-382 2.02e-11

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 65.10  E-value: 2.02e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462534232  89 RPYGCHECGKTFGRRFSLVLHQRTHTGEKPYAC--KECGKTFSQISNLVKHQMIHTGKKPHECKDCNKTFSYLSFLIE-- 164
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSls 111
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462534232 165 -----------------HQRTHTGEKPYECTEC--GKAFSRASNLTRHQRIHIGKKQYICR---KCGKAFSSGSELIRHQ 222
Cdd:COG5048   112 ssssnsndnnllsshslPPSSRDPQLPDLLSISnlRNNPLPGNNSSSVNTPQSNSLHPPLPansLSKDPSSNLSLLISSN 191
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462534232 223 ITHTGEKPYECIECGKaFRRFSHLTRHQSIHTTKTPYECNECRKAFRCHSFLIKHQRIHAGEKLYECDECGKVFTWHASL 302
Cdd:COG5048   192 VSTSIPSSSENSPLSS-SYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASS 270
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462534232 303 IQHTKSHTGE-------KPYACAECDKAFSRSFSLILHQRT--HTGE--KPYVCKV--CNKSFSWSSNLAKHQRTHTLDN 369
Cdd:COG5048   271 QSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSIS 350
                         330
                  ....*....|...
gi 2462534232 370 PYEYENSFNYHSF 382
Cdd:COG5048   351 PAKEKLLNSSSKF 363
zf-H2C2_2 pfam13465
Zinc-finger double domain;
162-186 5.56e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 5.56e-04
                          10        20
                  ....*....|....*....|....*
gi 2462534232 162 LIEHQRTHTGEKPYECTECGKAFSR 186
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
149-197 9.60e-04

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 37.92  E-value: 9.60e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 2462534232 149 CKDCNKTFSYLSFLIEHQRTHTgekpYECTECGKAFSRASNLTRH-QRIH 197
Cdd:cd20908     4 CYYCDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVHcLQVH 49
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
89-382 2.02e-11

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 65.10  E-value: 2.02e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462534232  89 RPYGCHECGKTFGRRFSLVLHQRTHTGEKPYAC--KECGKTFSQISNLVKHQMIHTGKKPHECKDCNKTFSYLSFLIE-- 164
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSls 111
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462534232 165 -----------------HQRTHTGEKPYECTEC--GKAFSRASNLTRHQRIHIGKKQYICR---KCGKAFSSGSELIRHQ 222
Cdd:COG5048   112 ssssnsndnnllsshslPPSSRDPQLPDLLSISnlRNNPLPGNNSSSVNTPQSNSLHPPLPansLSKDPSSNLSLLISSN 191
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462534232 223 ITHTGEKPYECIECGKaFRRFSHLTRHQSIHTTKTPYECNECRKAFRCHSFLIKHQRIHAGEKLYECDECGKVFTWHASL 302
Cdd:COG5048   192 VSTSIPSSSENSPLSS-SYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASS 270
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462534232 303 IQHTKSHTGE-------KPYACAECDKAFSRSFSLILHQRT--HTGE--KPYVCKV--CNKSFSWSSNLAKHQRTHTLDN 369
Cdd:COG5048   271 QSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSIS 350
                         330
                  ....*....|...
gi 2462534232 370 PYEYENSFNYHSF 382
Cdd:COG5048   351 PAKEKLLNSSSKF 363
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
117-270 1.29e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 56.63  E-value: 1.29e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462534232 117 KPYACKECGKTFSQISNLVKHQ--MIHTGK--KPHEC--KDCNKTFSYLSFLIEHQRTHTGEKPYEC--TECGKAFSRAS 188
Cdd:COG5048   288 LPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLL 367
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462534232 189 NLTRHQRIHI-----GKKQYIC--RKCGKAFSSGSELIRHQITHTGEKPYEC--IECGKAFRRFSHLTRHQSIHTTKTPY 259
Cdd:COG5048   368 NNEPPQSLQQykdlkNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCknPPCSKSFNRHYNLIPHKKIHTNHAPL 447
                         170
                  ....*....|.
gi 2462534232 260 ECNECRKAFRC 270
Cdd:COG5048   448 LCSILKSFRRD 458
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
132-385 5.67e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 51.24  E-value: 5.67e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462534232 132 SNLVKHQMIHTGKKPHECKDCNKTFSYLSFLIEHQRTHTG-EKPYECTECGKAFSRASNLTRHQRIHIgkkqyicrkcgk 210
Cdd:COG5048   246 SSLSSSDSSSSASESPRSSLPTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSVN------------ 313
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462534232 211 afSSGSELIRHQITHTGekpyecieCGKAFRRFSHLTRHQSIHTTKTPYECNECRkafRCHSFLIKhqrihageklyecd 290
Cdd:COG5048   314 --HSGESLKPFSCPYSL--------CGKLFSRNDALKRHILLHTSISPAKEKLLN---SSSKFSPL-------------- 366
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462534232 291 ecgkVFTWHASLIQHTKSHTGEKPYACA--ECDKAFSRSFSLILHQRTHTGEKPYVCK--VCNKSFSWSSNLAKHQRTHT 366
Cdd:COG5048   367 ----LNNEPPQSLQQYKDLKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHT 442
                         250
                  ....*....|....*....
gi 2462534232 367 LDNPYEYENSFNYHSFLTE 385
Cdd:COG5048   443 NHAPLLCSILKSFRRDLDL 461
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
96-217 6.92e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 44.69  E-value: 6.92e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462534232  96 CGKTFGRRFSLVLHQRTHTGEKPYACK--ECGKTFSQISNLVKHQMIHTGKKPHECK-------DCNKTFSYLSFLIEHQ 166
Cdd:COG5048   329 CGKLFSRNDALKRHILLHTSISPAKEKllNSSSKFSPLLNNEPPQSLQQYKDLKNDKksetlsnSCIRNFKRDSNLSLHI 408
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2462534232 167 RTHTGEKPYEC--TECGKAFSRASNLTRHQRIHIGKKQYICRKCGKAFSSGSE 217
Cdd:COG5048   409 ITHLSFRPYNCknPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDL 461
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
311-368 2.71e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 42.78  E-value: 2.71e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2462534232 311 GEKPYACA--ECDKAFSRSFSLILH-------QRTH------------TGEKPYVCKVCNKSFSwSSNLAKHQRTHTLD 368
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYHmlhghqnQKLHenpspekmnifsAKDKPYRCEVCDKRYK-NLNGLKYHRKHSHD 423
zf-H2C2_2 pfam13465
Zinc-finger double domain;
162-186 5.56e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 5.56e-04
                          10        20
                  ....*....|....*....|....*
gi 2462534232 162 LIEHQRTHTGEKPYECTECGKAFSR 186
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
217-242 7.25e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 7.25e-04
                          10        20
                  ....*....|....*....|....*.
gi 2462534232 217 ELIRHQITHTGEKPYECIECGKAFRR 242
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
149-197 9.60e-04

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 37.92  E-value: 9.60e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 2462534232 149 CKDCNKTFSYLSFLIEHQRTHTgekpYECTECGKAFSRASNLTRH-QRIH 197
Cdd:cd20908     4 CYYCDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVHcLQVH 49
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
175-197 1.03e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 36.12  E-value: 1.03e-03
                          10        20
                  ....*....|....*....|...
gi 2462534232 175 YECTECGKAFSRASNLTRHQRIH 197
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
105-130 1.20e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 1.20e-03
                          10        20
                  ....*....|....*....|....*.
gi 2462534232 105 SLVLHQRTHTGEKPYACKECGKTFSQ 130
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
299-386 1.46e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 40.45  E-value: 1.46e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462534232 299 HASLIQHTKSHTGE----KPYACAECDKAFSRSFSLILHQRTHTGEKPYVCKV--CNKSFSWSSNLAKHQRTHTLDNPYE 372
Cdd:COG5048    14 SVLSSTPKSTLKSLsnapRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDL 93
                          90
                  ....*....|....
gi 2462534232 373 YENSFNYHSFLTEH 386
Cdd:COG5048    94 NSKSLPLSNSKASS 107
zf-H2C2_2 pfam13465
Zinc-finger double domain;
301-326 2.05e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 2.05e-03
                          10        20
                  ....*....|....*....|....*.
gi 2462534232 301 SLIQHTKSHTGEKPYACAECDKAFSR 326
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
133-158 9.79e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 33.50  E-value: 9.79e-03
                          10        20
                  ....*....|....*....|....*.
gi 2462534232 133 NLVKHQMIHTGKKPHECKDCNKTFSY 158
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
329-353 9.98e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 33.50  E-value: 9.98e-03
                          10        20
                  ....*....|....*....|....*
gi 2462534232 329 SLILHQRTHTGEKPYVCKVCNKSFS 353
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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