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Conserved domains on  [gi|2462534910|ref|XP_054229450|]
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voltage-gated hydrogen channel 1 isoform X1 [Homo sapiens]

Protein Classification

VGPC1_C domain-containing protein( domain architecture ID 11245590)

VGPC1_C domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
VGPC1_C pfam16799
C-terminal membrane-localization domain of ion-channel, VCN1; VCN1_C is the short C-terminal ...
 273-320 1.74e-24

C-terminal membrane-localization domain of ion-channel, VCN1; VCN1_C is the short C-terminal region of voltage-gated proton channel 1 proteins in higher eukaryotes. The domain is necessary for achieving the dimeric architecture, two monomers form a dimer via parallel alpha-helical coiled-coil interaction. but it is also essential for localising the protein to an intracellular membrane.


:

Pssm-ID: 465275  Cd Length: 48  Bit Score: 93.47  E-value: 1.74e-24
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 2462534910 273 RQLLRLKQMNVQLAAKIQHLEFSCSEKEQEIERLNKLLRQHGLLGEVN 320
Cdd:pfam16799   1 QQLSRLKQMNLQLAAKIQHLEFSCSEKEQEIERLNKLLKQHGLLLQQE 48
 
Name Accession Description Interval E-value
VGPC1_C pfam16799
C-terminal membrane-localization domain of ion-channel, VCN1; VCN1_C is the short C-terminal ...
 273-320 1.74e-24

C-terminal membrane-localization domain of ion-channel, VCN1; VCN1_C is the short C-terminal region of voltage-gated proton channel 1 proteins in higher eukaryotes. The domain is necessary for achieving the dimeric architecture, two monomers form a dimer via parallel alpha-helical coiled-coil interaction. but it is also essential for localising the protein to an intracellular membrane.


Pssm-ID: 465275  Cd Length: 48  Bit Score: 93.47  E-value: 1.74e-24
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 2462534910 273 RQLLRLKQMNVQLAAKIQHLEFSCSEKEQEIERLNKLLRQHGLLGEVN 320
Cdd:pfam16799   1 QQLSRLKQMNLQLAAKIQHLEFSCSEKEQEIERLNKLLKQHGLLLQQE 48
 
Name Accession Description Interval E-value
VGPC1_C pfam16799
C-terminal membrane-localization domain of ion-channel, VCN1; VCN1_C is the short C-terminal ...
 273-320 1.74e-24

C-terminal membrane-localization domain of ion-channel, VCN1; VCN1_C is the short C-terminal region of voltage-gated proton channel 1 proteins in higher eukaryotes. The domain is necessary for achieving the dimeric architecture, two monomers form a dimer via parallel alpha-helical coiled-coil interaction. but it is also essential for localising the protein to an intracellular membrane.


Pssm-ID: 465275  Cd Length: 48  Bit Score: 93.47  E-value: 1.74e-24
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 2462534910 273 RQLLRLKQMNVQLAAKIQHLEFSCSEKEQEIERLNKLLRQHGLLGEVN 320
Cdd:pfam16799   1 QQLSRLKQMNLQLAAKIQHLEFSCSEKEQEIERLNKLLKQHGLLLQQE 48
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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