NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|2462537572|ref|XP_054230744|]
View 

RING finger protein 17 isoform X11 [Homo sapiens]

Protein Classification

tudor domain-containing protein( domain architecture ID 15333351)

tudor domain-containing protein adopts a beta-barrel-like structure and may bind to proteins with dimethylated arginine or lysine residues, or to methylated histone tails to facilitate protein-protein interactions; similar to Homo sapiens RING finger protein 17 involved in regulation of transcriptional activity of MYC

CATH:  2.30.30.140
Gene Ontology:  GO:0005515
PubMed:  24035451|22669818|20728048
SCOP:  4003195

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Tudor_TDRD4_rpt5 cd20418
fifth Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; ...
 1115-1219 9.46e-66

fifth Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; TDRD4, also called RING finger protein 17 (RNF17), is a component of the mammalian germ cell nuage and is essential for spermiogenesis. It seems to be involved in the regulation of transcriptional activity of MYC. In vitro, TDRD4 inhibits the DNA-binding activity of Mad-MAX heterodimers. It can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. TDRD4 also acts as a potential cancer/testis antigen in liver cancer. TDRD4 contains a RING finger and five Tudor domains. This model corresponds to the fifth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


:

Pssm-ID: 410489  Cd Length: 105  Bit Score: 216.89  E-value: 9.46e-66
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462537572 1115 LTDFRTEMPCLAEYDDGLWYRAKIVAIKEFNPLSILVQFVDYGSTAKLTLNRLCQIPSHLMRYPARAIKVLLAGFKPPLR 1194
Cdd:cd20418      1 LTDFRPEMPCLAEYSDGKWYRAKLLSILEFNPVKILVRHVDYGSTAALPTSRLRQIPAELMQYPCQAIKVKLAGFKPPLN 80

                           90       100
                   ....*....|....*....|....*
gi 2462537572 1195 DLGETRIPYCPKWSMEALWAMIDCL 1219
Cdd:cd20418     81 DSETERIPYCPEWSMKALWAMIDLL 105
Tudor_TDRD4_rpt2 cd20415
second Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; ...
 292-436 3.37e-45

second Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; TDRD4, also called RING finger protein 17 (RNF17), is a component of the mammalian germ cell nuage and is essential for spermiogenesis. It seems to be involved in the regulation of transcriptional activity of MYC. In vitro, TDRD4 inhibits the DNA-binding activity of Mad-MAX heterodimers. It can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. TDRD4 also acts as a potential cancer/testis antigen in liver cancer. TDRD4 contains a RING finger and five Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


:

Pssm-ID: 410486  Cd Length: 96  Bit Score: 157.98  E-value: 3.37e-45
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462537572  292 ILFLLKTIEEFYKSEDGENLEILCPVQDQACVAKFEDGIWYRAKVIelnhwescwkscidrtkqqkliiqkpvnsslmlt 371
Cdd:cd20415      1 FLILTKKIQEFYKEGDDGGLEILCPVQGQACVALFEDGAWYRARII---------------------------------- 46

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2462537572  372 vclshailivkvqikGLPGHQEVEVKYVDFGNTAKITIKDVRKIKDEFLNAPEKAIKCKLAYIEP 436
Cdd:cd20415     47 ---------------GLPGHREVEVKYVDFGNTATVTIKHVRKIKDDFLSLPEKARECRLAFIEP 96
Tudor_TDRD4_rpt3 cd20416
third Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; ...
 583-664 4.03e-43

third Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; TDRD4, also called RING finger protein 17 (RNF17), is a component of the mammalian germ cell nuage and is essential for spermiogenesis. It seems to be involved in the regulation of transcriptional activity of MYC. In vitro, TDRD4 inhibits the DNA-binding activity of Mad-MAX heterodimers. It can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. TDRD4 also acts as a potential cancer/testis antigen in liver cancer. TDRD4 contains a RING finger and five Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


:

Pssm-ID: 410487  Cd Length: 82  Bit Score: 151.49  E-value: 4.03e-43
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462537572  583 LEEKMIAAYENSKWEPVKWENDMHCAVKIQDKNQWRRGQIIRMVTDTLVEVLLYDVGVELVVNVDCLRKLEENLKTMGRL 662
Cdd:cd20416      1 LQEKMIAEYENSKPEPVKWENDMHCAVQIQDKKQWRRGQIIRVVSDTLVEVFLYDFGNKEVVNIDCLRKLEENLKTIGKL 80


                   ..
gi 2462537572  663 SL 664
Cdd:cd20416     81 AL 82
Tudor_TDRD4_rpt4 cd20417
fourth Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; ...
 867-934 8.95e-42

fourth Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; TDRD4, also called RING finger protein 17 (RNF17), is a component of the mammalian germ cell nuage and is essential for spermiogenesis. It seems to be involved in the regulation of transcriptional activity of MYC. In vitro, TDRD4 inhibits the DNA-binding activity of Mad-MAX heterodimers. It can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. TDRD4 also acts as a potential cancer/testis antigen in liver cancer. TDRD4 contains a RING finger and five Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


:

Pssm-ID: 410488  Cd Length: 68  Bit Score: 147.20  E-value: 8.95e-42
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2462537572  867 WKKGEACAVRGSDTLWYRGKVMEVVGGAVRVQYLDHGFTEKIPQCHLYPILLYPDIPQFCIPCQLHNT 934
Cdd:cd20417      1 WKKGEGCVVRGSDTLWYRGKVLEVIGGMVRVQYVDQGYIEKIPQCHLYPMVLYPDIPQFCIPCQLYGT 68
Tudor_TDRD4_rpt1 cd20414
first Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; ...
 54-130 4.41e-38

first Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; TDRD4, also called RING finger protein 17 (RNF17), is a component of the mammalian germ cell nuage and is essential for spermiogenesis. It seems to be involved in the regulation of transcriptional activity of MYC. In vitro, TDRD4 inhibits the DNA-binding activity of Mad-MAX heterodimers. It can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. TDRD4 also acts as a potential cancer/testis antigen in liver cancer. TDRD4 contains a RING finger and five Tudor domains. This model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


:

Pssm-ID: 410485  Cd Length: 77  Bit Score: 136.95  E-value: 4.41e-38
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2462537572   54 ELGARIFVSSIKNGMWCRGTITELIPIEGRNTRKPCSPTRLFVHEVALIQIFMVDFGNSEVLIVTGVVDTHVRPEHS 130
Cdd:cd20414      1 ELGERIAVKSKKNGMWCRGTITELIPLENKNKGKPCGPTRYKIHDVAVMQVFLLDYGHSEVFVVTGVGVLVVRPEDV 77
 
Name Accession Description Interval E-value
Tudor_TDRD4_rpt5 cd20418
fifth Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; ...
 1115-1219 9.46e-66

fifth Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; TDRD4, also called RING finger protein 17 (RNF17), is a component of the mammalian germ cell nuage and is essential for spermiogenesis. It seems to be involved in the regulation of transcriptional activity of MYC. In vitro, TDRD4 inhibits the DNA-binding activity of Mad-MAX heterodimers. It can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. TDRD4 also acts as a potential cancer/testis antigen in liver cancer. TDRD4 contains a RING finger and five Tudor domains. This model corresponds to the fifth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410489  Cd Length: 105  Bit Score: 216.89  E-value: 9.46e-66
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462537572 1115 LTDFRTEMPCLAEYDDGLWYRAKIVAIKEFNPLSILVQFVDYGSTAKLTLNRLCQIPSHLMRYPARAIKVLLAGFKPPLR 1194
Cdd:cd20418      1 LTDFRPEMPCLAEYSDGKWYRAKLLSILEFNPVKILVRHVDYGSTAALPTSRLRQIPAELMQYPCQAIKVKLAGFKPPLN 80

                           90       100
                   ....*....|....*....|....*
gi 2462537572 1195 DLGETRIPYCPKWSMEALWAMIDCL 1219
Cdd:cd20418     81 DSETERIPYCPEWSMKALWAMIDLL 105
Tudor_TDRD4_rpt2 cd20415
second Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; ...
 292-436 3.37e-45

second Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; TDRD4, also called RING finger protein 17 (RNF17), is a component of the mammalian germ cell nuage and is essential for spermiogenesis. It seems to be involved in the regulation of transcriptional activity of MYC. In vitro, TDRD4 inhibits the DNA-binding activity of Mad-MAX heterodimers. It can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. TDRD4 also acts as a potential cancer/testis antigen in liver cancer. TDRD4 contains a RING finger and five Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410486  Cd Length: 96  Bit Score: 157.98  E-value: 3.37e-45
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462537572  292 ILFLLKTIEEFYKSEDGENLEILCPVQDQACVAKFEDGIWYRAKVIelnhwescwkscidrtkqqkliiqkpvnsslmlt 371
Cdd:cd20415      1 FLILTKKIQEFYKEGDDGGLEILCPVQGQACVALFEDGAWYRARII---------------------------------- 46

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2462537572  372 vclshailivkvqikGLPGHQEVEVKYVDFGNTAKITIKDVRKIKDEFLNAPEKAIKCKLAYIEP 436
Cdd:cd20415     47 ---------------GLPGHREVEVKYVDFGNTATVTIKHVRKIKDDFLSLPEKARECRLAFIEP 96
Tudor_TDRD4_rpt3 cd20416
third Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; ...
 583-664 4.03e-43

third Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; TDRD4, also called RING finger protein 17 (RNF17), is a component of the mammalian germ cell nuage and is essential for spermiogenesis. It seems to be involved in the regulation of transcriptional activity of MYC. In vitro, TDRD4 inhibits the DNA-binding activity of Mad-MAX heterodimers. It can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. TDRD4 also acts as a potential cancer/testis antigen in liver cancer. TDRD4 contains a RING finger and five Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410487  Cd Length: 82  Bit Score: 151.49  E-value: 4.03e-43
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462537572  583 LEEKMIAAYENSKWEPVKWENDMHCAVKIQDKNQWRRGQIIRMVTDTLVEVLLYDVGVELVVNVDCLRKLEENLKTMGRL 662
Cdd:cd20416      1 LQEKMIAEYENSKPEPVKWENDMHCAVQIQDKKQWRRGQIIRVVSDTLVEVFLYDFGNKEVVNIDCLRKLEENLKTIGKL 80


                   ..
gi 2462537572  663 SL 664
Cdd:cd20416     81 AL 82
Tudor_TDRD4_rpt4 cd20417
fourth Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; ...
 867-934 8.95e-42

fourth Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; TDRD4, also called RING finger protein 17 (RNF17), is a component of the mammalian germ cell nuage and is essential for spermiogenesis. It seems to be involved in the regulation of transcriptional activity of MYC. In vitro, TDRD4 inhibits the DNA-binding activity of Mad-MAX heterodimers. It can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. TDRD4 also acts as a potential cancer/testis antigen in liver cancer. TDRD4 contains a RING finger and five Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410488  Cd Length: 68  Bit Score: 147.20  E-value: 8.95e-42
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2462537572  867 WKKGEACAVRGSDTLWYRGKVMEVVGGAVRVQYLDHGFTEKIPQCHLYPILLYPDIPQFCIPCQLHNT 934
Cdd:cd20417      1 WKKGEGCVVRGSDTLWYRGKVLEVIGGMVRVQYVDQGYIEKIPQCHLYPMVLYPDIPQFCIPCQLYGT 68
Tudor_TDRD4_rpt1 cd20414
first Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; ...
 54-130 4.41e-38

first Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; TDRD4, also called RING finger protein 17 (RNF17), is a component of the mammalian germ cell nuage and is essential for spermiogenesis. It seems to be involved in the regulation of transcriptional activity of MYC. In vitro, TDRD4 inhibits the DNA-binding activity of Mad-MAX heterodimers. It can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. TDRD4 also acts as a potential cancer/testis antigen in liver cancer. TDRD4 contains a RING finger and five Tudor domains. This model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410485  Cd Length: 77  Bit Score: 136.95  E-value: 4.41e-38
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2462537572   54 ELGARIFVSSIKNGMWCRGTITELIPIEGRNTRKPCSPTRLFVHEVALIQIFMVDFGNSEVLIVTGVVDTHVRPEHS 130
Cdd:cd20414      1 ELGERIAVKSKKNGMWCRGTITELIPLENKNKGKPCGPTRYKIHDVAVMQVFLLDYGHSEVFVVTGVGVLVVRPEDV 77
TUDOR pfam00567
Tudor domain;
819-933 2.33e-24

Tudor domain;


Pssm-ID: 425754 [Multi-domain]  Cd Length: 117  Bit Score: 98.97  E-value: 2.33e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462537572  819 NVFEATVSCVGDDGTIFVVPKLSEFELIKMTNEIQSNLKCLGLLEPYFWKKGEACAVRGSDTLWYRGKVMEVV-GGAVRV 897
Cdd:pfam00567    1 STIDVVVSHIESPSTFYIQPKSDSKKLEKLTEELQEYYASKPPESLPPAVGDGCVAAFSEDGKWYRAKITESLdDGLVEV 80

                           90       100       110
                   ....*....|....*....|....*....|....*..
gi 2462537572  898 QYLDHGFTEKIPQCHLYPILLYPD-IPQFCIPCQLHN 933
Cdd:pfam00567   81 LFIDYGNTETVPLSDLRPLPPELEsLPPQAIKCQLAG 117
TUDOR pfam00567
Tudor domain;
268-432 1.47e-13

Tudor domain;


Pssm-ID: 425754 [Multi-domain]  Cd Length: 117  Bit Score: 68.15  E-value: 1.47e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462537572  268 DVSVTVCHINSPGDFYLQLIEGLDILF-LLKTIEEFYKSeDGENLEILCPVQDQACVAKfEDGIWYRAKVIELnhwescw 346
Cdd:pfam00567    2 TIDVVVSHIESPSTFYIQPKSDSKKLEkLTEELQEYYAS-KPPESLPPAVGDGCVAAFS-EDGKWYRAKITES------- 72

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462537572  347 kscidrtkqqkliiqkpvnsslmltvclshailivkvqikglPGHQEVEVKYVDFGNTAKITIKDVRKIKDEFLNAPEKA 426
Cdd:pfam00567   73 ------------------------------------------LDDGLVEVLFIDYGNTETVPLSDLRPLPPELESLPPQA 110


                   ....*.
gi 2462537572  427 IKCKLA 432
Cdd:pfam00567  111 IKCQLA 116
TUDOR pfam00567
Tudor domain;
1053-1188 1.50e-13

Tudor domain;


Pssm-ID: 425754 [Multi-domain]  Cd Length: 117  Bit Score: 68.15  E-value: 1.50e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462537572 1053 AVQVKHVVSPNEVYIcldsietsnQSnqhsdtddsgVSGESESESLDEALQRVNKKVEAlPPLTDFRTEMPCLAEYDDGL 1132
Cdd:pfam00567    4 DVVVSHIESPSTFYI---------QP----------KSDSKKLEKLTEELQEYYASKPP-ESLPPAVGDGCVAAFSEDGK 63

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 2462537572 1133 WYRAKIVAIKEfNPLsILVQFVDYGSTAKLTLNRLCQIPSHLMRYPARAIKVLLAG 1188
Cdd:pfam00567   64 WYRAKITESLD-DGL-VEVLFIDYGNTETVPLSDLRPLPPELESLPPQAIKCQLAG 117
TUDOR pfam00567
Tudor domain;
558-668 3.98e-11

Tudor domain;


Pssm-ID: 425754 [Multi-domain]  Cd Length: 117  Bit Score: 61.22  E-value: 3.98e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462537572  558 VHICNVISPEKIYVQWLLTENLLNSLEEKMIAAYENSKWEPVKWENDMHCAVKIQDKNQWRRGQIIRMVTDTLVEVLLYD 637
Cdd:pfam00567    5 VVVSHIESPSTFYIQPKSDSKKLEKLTEELQEYYASKPPESLPPAVGDGCVAAFSEDGKWYRAKITESLDDGLVEVLFID 84

                           90       100       110
                   ....*....|....*....|....*....|.
gi 2462537572  638 VGVELVVNVDCLRKLEENLKTMGRLSLECSL 668
Cdd:pfam00567   85 YGNTETVPLSDLRPLPPELESLPPQAIKCQL 115
TUDOR smart00333
Tudor domain; Domain of unknown function present in several RNA-binding proteins. 10 copies in ...
 1122-1174 3.68e-09

Tudor domain; Domain of unknown function present in several RNA-binding proteins. 10 copies in the Drosophila Tudor protein. Initial proposal that the survival motor neuron gene product contain a Tudor domain are corroborated by more recent database search techniques such as PSI-BLAST (unpublished).


Pssm-ID: 197660  Cd Length: 57  Bit Score: 53.82  E-value: 3.68e-09
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|...
gi 2462537572  1122 MPCLAEYDDGLWYRAKIVAIKEFNplSILVQFVDYGSTAKLTLNRLCQIPSHL 1174
Cdd:smart00333    7 DKVAARWEDGEWYRARIVKVDGEQ--LYEVFFIDYGNEEVVPPSDLRQLPEEL 57
TUDOR pfam00567
Tudor domain;
8-115 1.29e-08

Tudor domain;


Pssm-ID: 425754 [Multi-domain]  Cd Length: 117  Bit Score: 54.28  E-value: 1.29e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462537572    8 VFVSHVIDPCHFYIRKYSQIKDAKVLEKKVNEFCNRSSHLDPSDILELGARIFVSSikNGMWCRGTITELIPIEgrntrk 87
Cdd:pfam00567    5 VVVSHIESPSTFYIQPKSDSKKLEKLTEELQEYYASKPPESLPPAVGDGCVAAFSE--DGKWYRAKITESLDDG------ 76

                           90       100
                   ....*....|....*....|....*...
gi 2462537572   88 pcsptrlfvhevaLIQIFMVDFGNSEVL 115
Cdd:pfam00567   77 -------------LVEVLFIDYGNTETV 91
TUDOR smart00333
Tudor domain; Domain of unknown function present in several RNA-binding proteins. 10 copies in ...
 867-916 1.60e-08

Tudor domain; Domain of unknown function present in several RNA-binding proteins. 10 copies in the Drosophila Tudor protein. Initial proposal that the survival motor neuron gene product contain a Tudor domain are corroborated by more recent database search techniques such as PSI-BLAST (unpublished).


Pssm-ID: 197660  Cd Length: 57  Bit Score: 51.89  E-value: 1.60e-08
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|.
gi 2462537572   867 WKKGEACAVRGSDTLWYRGKVMEVVG-GAVRVQYLDHGFTEKIPQCHLYPI 916
Cdd:smart00333    3 FKVGDKVAARWEDGEWYRARIVKVDGeQLYEVFFIDYGNEEVVPPSDLRQL 53
TUDOR smart00333
Tudor domain; Domain of unknown function present in several RNA-binding proteins. 10 copies in ...
 598-654 1.44e-05

Tudor domain; Domain of unknown function present in several RNA-binding proteins. 10 copies in the Drosophila Tudor protein. Initial proposal that the survival motor neuron gene product contain a Tudor domain are corroborated by more recent database search techniques such as PSI-BLAST (unpublished).


Pssm-ID: 197660  Cd Length: 57  Bit Score: 43.80  E-value: 1.44e-05
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*..
gi 2462537572   598 PVKWENDMhCAVKIQDkNQWRRGQIIRMVTDTLVEVLLYDVGVELVVNVDCLRKLEE 654
Cdd:smart00333    1 PTFKVGDK-VAARWED-GEWYRARIVKVDGEQLYEVFFIDYGNEEVVPPSDLRQLPE 55
TUDOR smart00333
Tudor domain; Domain of unknown function present in several RNA-binding proteins. 10 copies in ...
 320-419 3.01e-03

Tudor domain; Domain of unknown function present in several RNA-binding proteins. 10 copies in the Drosophila Tudor protein. Initial proposal that the survival motor neuron gene product contain a Tudor domain are corroborated by more recent database search techniques such as PSI-BLAST (unpublished).


Pssm-ID: 197660  Cd Length: 57  Bit Score: 37.25  E-value: 3.01e-03
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462537572   320 QACVAKFEDGIWYRAKVIElnhwescwkscIDRTkqqkliiqkpvnsslmltvclshailivkvqikglpghQEVEVKYV 399
Cdd:smart00333    7 DKVAARWEDGEWYRARIVK-----------VDGE--------------------------------------QLYEVFFI 37

                            90       100
                    ....*....|....*....|
gi 2462537572   400 DFGNTAKITIKDVRKIKDEF 419
Cdd:smart00333   38 DYGNEEVVPPSDLRQLPEEL 57
 
Name Accession Description Interval E-value
Tudor_TDRD4_rpt5 cd20418
fifth Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; ...
 1115-1219 9.46e-66

fifth Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; TDRD4, also called RING finger protein 17 (RNF17), is a component of the mammalian germ cell nuage and is essential for spermiogenesis. It seems to be involved in the regulation of transcriptional activity of MYC. In vitro, TDRD4 inhibits the DNA-binding activity of Mad-MAX heterodimers. It can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. TDRD4 also acts as a potential cancer/testis antigen in liver cancer. TDRD4 contains a RING finger and five Tudor domains. This model corresponds to the fifth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410489  Cd Length: 105  Bit Score: 216.89  E-value: 9.46e-66
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462537572 1115 LTDFRTEMPCLAEYDDGLWYRAKIVAIKEFNPLSILVQFVDYGSTAKLTLNRLCQIPSHLMRYPARAIKVLLAGFKPPLR 1194
Cdd:cd20418      1 LTDFRPEMPCLAEYSDGKWYRAKLLSILEFNPVKILVRHVDYGSTAALPTSRLRQIPAELMQYPCQAIKVKLAGFKPPLN 80

                           90       100
                   ....*....|....*....|....*
gi 2462537572 1195 DLGETRIPYCPKWSMEALWAMIDCL 1219
Cdd:cd20418     81 DSETERIPYCPEWSMKALWAMIDLL 105
Tudor_TDRD4_rpt2 cd20415
second Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; ...
 292-436 3.37e-45

second Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; TDRD4, also called RING finger protein 17 (RNF17), is a component of the mammalian germ cell nuage and is essential for spermiogenesis. It seems to be involved in the regulation of transcriptional activity of MYC. In vitro, TDRD4 inhibits the DNA-binding activity of Mad-MAX heterodimers. It can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. TDRD4 also acts as a potential cancer/testis antigen in liver cancer. TDRD4 contains a RING finger and five Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410486  Cd Length: 96  Bit Score: 157.98  E-value: 3.37e-45
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462537572  292 ILFLLKTIEEFYKSEDGENLEILCPVQDQACVAKFEDGIWYRAKVIelnhwescwkscidrtkqqkliiqkpvnsslmlt 371
Cdd:cd20415      1 FLILTKKIQEFYKEGDDGGLEILCPVQGQACVALFEDGAWYRARII---------------------------------- 46

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2462537572  372 vclshailivkvqikGLPGHQEVEVKYVDFGNTAKITIKDVRKIKDEFLNAPEKAIKCKLAYIEP 436
Cdd:cd20415     47 ---------------GLPGHREVEVKYVDFGNTATVTIKHVRKIKDDFLSLPEKARECRLAFIEP 96
Tudor_TDRD4_rpt3 cd20416
third Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; ...
 583-664 4.03e-43

third Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; TDRD4, also called RING finger protein 17 (RNF17), is a component of the mammalian germ cell nuage and is essential for spermiogenesis. It seems to be involved in the regulation of transcriptional activity of MYC. In vitro, TDRD4 inhibits the DNA-binding activity of Mad-MAX heterodimers. It can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. TDRD4 also acts as a potential cancer/testis antigen in liver cancer. TDRD4 contains a RING finger and five Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410487  Cd Length: 82  Bit Score: 151.49  E-value: 4.03e-43
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462537572  583 LEEKMIAAYENSKWEPVKWENDMHCAVKIQDKNQWRRGQIIRMVTDTLVEVLLYDVGVELVVNVDCLRKLEENLKTMGRL 662
Cdd:cd20416      1 LQEKMIAEYENSKPEPVKWENDMHCAVQIQDKKQWRRGQIIRVVSDTLVEVFLYDFGNKEVVNIDCLRKLEENLKTIGKL 80


                   ..
gi 2462537572  663 SL 664
Cdd:cd20416     81 AL 82
Tudor_TDRD4_rpt4 cd20417
fourth Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; ...
 867-934 8.95e-42

fourth Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; TDRD4, also called RING finger protein 17 (RNF17), is a component of the mammalian germ cell nuage and is essential for spermiogenesis. It seems to be involved in the regulation of transcriptional activity of MYC. In vitro, TDRD4 inhibits the DNA-binding activity of Mad-MAX heterodimers. It can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. TDRD4 also acts as a potential cancer/testis antigen in liver cancer. TDRD4 contains a RING finger and five Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410488  Cd Length: 68  Bit Score: 147.20  E-value: 8.95e-42
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2462537572  867 WKKGEACAVRGSDTLWYRGKVMEVVGGAVRVQYLDHGFTEKIPQCHLYPILLYPDIPQFCIPCQLHNT 934
Cdd:cd20417      1 WKKGEGCVVRGSDTLWYRGKVLEVIGGMVRVQYVDQGYIEKIPQCHLYPMVLYPDIPQFCIPCQLYGT 68
Tudor_TDRD4_rpt1 cd20414
first Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; ...
 54-130 4.41e-38

first Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; TDRD4, also called RING finger protein 17 (RNF17), is a component of the mammalian germ cell nuage and is essential for spermiogenesis. It seems to be involved in the regulation of transcriptional activity of MYC. In vitro, TDRD4 inhibits the DNA-binding activity of Mad-MAX heterodimers. It can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. TDRD4 also acts as a potential cancer/testis antigen in liver cancer. TDRD4 contains a RING finger and five Tudor domains. This model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410485  Cd Length: 77  Bit Score: 136.95  E-value: 4.41e-38
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2462537572   54 ELGARIFVSSIKNGMWCRGTITELIPIEGRNTRKPCSPTRLFVHEVALIQIFMVDFGNSEVLIVTGVVDTHVRPEHS 130
Cdd:cd20414      1 ELGERIAVKSKKNGMWCRGTITELIPLENKNKGKPCGPTRYKIHDVAVMQVFLLDYGHSEVFVVTGVGVLVVRPEDV 77
TUDOR pfam00567
Tudor domain;
819-933 2.33e-24

Tudor domain;


Pssm-ID: 425754 [Multi-domain]  Cd Length: 117  Bit Score: 98.97  E-value: 2.33e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462537572  819 NVFEATVSCVGDDGTIFVVPKLSEFELIKMTNEIQSNLKCLGLLEPYFWKKGEACAVRGSDTLWYRGKVMEVV-GGAVRV 897
Cdd:pfam00567    1 STIDVVVSHIESPSTFYIQPKSDSKKLEKLTEELQEYYASKPPESLPPAVGDGCVAAFSEDGKWYRAKITESLdDGLVEV 80

                           90       100       110
                   ....*....|....*....|....*....|....*..
gi 2462537572  898 QYLDHGFTEKIPQCHLYPILLYPD-IPQFCIPCQLHN 933
Cdd:pfam00567   81 LFIDYGNTETVPLSDLRPLPPELEsLPPQAIKCQLAG 117
TUDOR pfam00567
Tudor domain;
268-432 1.47e-13

Tudor domain;


Pssm-ID: 425754 [Multi-domain]  Cd Length: 117  Bit Score: 68.15  E-value: 1.47e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462537572  268 DVSVTVCHINSPGDFYLQLIEGLDILF-LLKTIEEFYKSeDGENLEILCPVQDQACVAKfEDGIWYRAKVIELnhwescw 346
Cdd:pfam00567    2 TIDVVVSHIESPSTFYIQPKSDSKKLEkLTEELQEYYAS-KPPESLPPAVGDGCVAAFS-EDGKWYRAKITES------- 72

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462537572  347 kscidrtkqqkliiqkpvnsslmltvclshailivkvqikglPGHQEVEVKYVDFGNTAKITIKDVRKIKDEFLNAPEKA 426
Cdd:pfam00567   73 ------------------------------------------LDDGLVEVLFIDYGNTETVPLSDLRPLPPELESLPPQA 110


                   ....*.
gi 2462537572  427 IKCKLA 432
Cdd:pfam00567  111 IKCQLA 116
TUDOR pfam00567
Tudor domain;
1053-1188 1.50e-13

Tudor domain;


Pssm-ID: 425754 [Multi-domain]  Cd Length: 117  Bit Score: 68.15  E-value: 1.50e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462537572 1053 AVQVKHVVSPNEVYIcldsietsnQSnqhsdtddsgVSGESESESLDEALQRVNKKVEAlPPLTDFRTEMPCLAEYDDGL 1132
Cdd:pfam00567    4 DVVVSHIESPSTFYI---------QP----------KSDSKKLEKLTEELQEYYASKPP-ESLPPAVGDGCVAAFSEDGK 63

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 2462537572 1133 WYRAKIVAIKEfNPLsILVQFVDYGSTAKLTLNRLCQIPSHLMRYPARAIKVLLAG 1188
Cdd:pfam00567   64 WYRAKITESLD-DGL-VEVLFIDYGNTETVPLSDLRPLPPELESLPPQAIKCQLAG 117
Tudor_TDRD12_rpt2 cd20435
second Tudor domain found in Tudor domain-containing protein 12 (TDRD12) and similar proteins; ...
 1124-1195 1.33e-11

second Tudor domain found in Tudor domain-containing protein 12 (TDRD12) and similar proteins; TDRD12, also called ES cell-associated transcript 8 protein (ECAT8), is a putative ATP-dependent DEAD-like RNA helicase that is essential for germ cell development and maintenance. It acts as a unique piRNA biogenesis factor essential for secondary PIWI interacting RNA (piRNA) biogenesis. TDRD12 contains two Tudor domains, one at the N-terminus and the other at the C-terminal end. The model corresponds to the second/C-terminal one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410506  Cd Length: 134  Bit Score: 63.42  E-value: 1.33e-11
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462537572 1124 CLAEYDDGLWYRAKIVAIKEFN----PLSILVQFVDYGSTAKLTLNRLCQIPSHLMRYPARAIKVLLAGFKPPLRD 1195
Cdd:cd20435     56 CAVEDENNLYHRVKVLEITEKDdktkPREVLVKFIDEGRVETVVVSQLLELPEELKSLPPQAVEVFLCNVKPVDND 131
Tudor_TDRD15_rpt4 cd20439
fourth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; ...
 269-431 3.59e-11

fourth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410510  Cd Length: 125  Bit Score: 61.74  E-value: 3.59e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462537572  269 VSVTVCHINSPGDFYLQLI-EGLDILFLLKTIEEFYK--SEDGENLEIlcpvqdqACVAKF-EDGIWYRAKVielnhwes 344
Cdd:cd20439     12 VDVKCSYVNSPGDFWCQLQtKSSELKSLMKQIQSYYLihNDPYKHGQI-------ACVAKYsKDGKWYRAAV-------- 76

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462537572  345 cwkscidrtkqQKLIIQKpvnsslmltvclshailivkvqikglpghqEVEVKYVDFGNTAKITIKDVRKIKDEFLNAPE 424
Cdd:cd20439     77 -----------LKQVSAK------------------------------EVDVIFVDYGNQERVLISDLRAIKPQFLLLEG 115


                   ....*..
gi 2462537572  425 KAIKCKL 431
Cdd:cd20439    116 QAFRCSL 122
TUDOR pfam00567
Tudor domain;
558-668 3.98e-11

Tudor domain;


Pssm-ID: 425754 [Multi-domain]  Cd Length: 117  Bit Score: 61.22  E-value: 3.98e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462537572  558 VHICNVISPEKIYVQWLLTENLLNSLEEKMIAAYENSKWEPVKWENDMHCAVKIQDKNQWRRGQIIRMVTDTLVEVLLYD 637
Cdd:pfam00567    5 VVVSHIESPSTFYIQPKSDSKKLEKLTEELQEYYASKPPESLPPAVGDGCVAAFSEDGKWYRAKITESLDDGLVEVLFID 84

                           90       100       110
                   ....*....|....*....|....*....|.
gi 2462537572  638 VGVELVVNVDCLRKLEENLKTMGRLSLECSL 668
Cdd:pfam00567   85 YGNTETVPLSDLRPLPPELESLPPQAIKCQL 115
Tudor_TDRD15_rpt5 cd20440
fifth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; ...
 271-431 1.22e-10

fifth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the fifth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410511  Cd Length: 127  Bit Score: 60.16  E-value: 1.22e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462537572  271 VTVCHINSPGDFYLQLIEGLDIL-FLLKTIEEFYKSEDGEnleILCPVQDQACVAK-FEDGIWYRAKVIelnhwescwks 348
Cdd:cd20440     14 VYITHVYSPAKFYCQLDRNTEILeALMEKIAEISKLFNSQ---ILDNCKTRLCLAKyFEDGQWYRALAH----------- 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462537572  349 cidrtkqqkliiqkPVNSSlmltvclshailivkvqikglpghQEVEVKYVDFGNTAKITIKDVRKIKDEF---LNAPEK 425
Cdd:cd20440     80 --------------PVESS------------------------SHLSVYFVDYGNKQIVEKNEVLPIPDTAvdlLLTPMQ 121


                   ....*.
gi 2462537572  426 AIKCKL 431
Cdd:cd20440    122 AIKCCL 127
TUDOR smart00333
Tudor domain; Domain of unknown function present in several RNA-binding proteins. 10 copies in ...
 1122-1174 3.68e-09

Tudor domain; Domain of unknown function present in several RNA-binding proteins. 10 copies in the Drosophila Tudor protein. Initial proposal that the survival motor neuron gene product contain a Tudor domain are corroborated by more recent database search techniques such as PSI-BLAST (unpublished).


Pssm-ID: 197660  Cd Length: 57  Bit Score: 53.82  E-value: 3.68e-09
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|...
gi 2462537572  1122 MPCLAEYDDGLWYRAKIVAIKEFNplSILVQFVDYGSTAKLTLNRLCQIPSHL 1174
Cdd:smart00333    7 DKVAARWEDGEWYRARIVKVDGEQ--LYEVFFIDYGNEEVVPPSDLRQLPEEL 57
Tudor_TDRD4_rpt2 cd20415
second Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; ...
 1124-1191 4.58e-09

second Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; TDRD4, also called RING finger protein 17 (RNF17), is a component of the mammalian germ cell nuage and is essential for spermiogenesis. It seems to be involved in the regulation of transcriptional activity of MYC. In vitro, TDRD4 inhibits the DNA-binding activity of Mad-MAX heterodimers. It can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. TDRD4 also acts as a potential cancer/testis antigen in liver cancer. TDRD4 contains a RING finger and five Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410486  Cd Length: 96  Bit Score: 54.75  E-value: 4.58e-09
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2462537572 1124 CLAEYDDGLWYRAKIVAIKEFNplSILVQFVDYGSTAKLTLNRLCQIPSHLMRYPARAIKVLLAGFKP 1191
Cdd:cd20415     31 CVALFEDGAWYRARIIGLPGHR--EVEVKYVDFGNTATVTIKHVRKIKDDFLSLPEKARECRLAFIEP 96
Tudor_dTUD-like cd20379
Tudor domain found in Drosophila melanogaster maternal protein Tudor (dTUD) and similar ...
 869-916 8.62e-09

Tudor domain found in Drosophila melanogaster maternal protein Tudor (dTUD) and similar proteins; dTUD is required during oogenesis for the formation of primordial germ cells and for normal abdominal segmentation. It contains 11 Tudor domains. The family also includes mitochondrial A-kinase anchor protein 1 (AKAP1) and Tudor domain-containing proteins (TDRDs). AKAP1, also called A-kinase anchor protein 149 kDa (AKAP 149), or dual specificity A-kinase-anchoring protein 1 (D-AKAP-1), or protein kinase A-anchoring protein 1 (PRKA1), or Spermatid A-kinase anchor protein 84 (S-AKAP84), is found in mitochondria and in the endoplasmic reticulum-nuclear envelope where it anchors protein kinases, phosphatases, and a phosphodiesterase. It regulates multiple cellular processes governing mitochondrial homeostasis and cell viability. AKAP1 binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane. TDRDs have diverse biological functions and may contain one or more copies of the Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410450  Cd Length: 50  Bit Score: 52.52  E-value: 8.62e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 2462537572  869 KGEACAVRGSDT-LWYRGKVMEVV-GGAVRVQYLDHGFTEKIPQCHLYPI 916
Cdd:cd20379      1 VGDLCAAKYEEDgKWYRARVLEVLsNDKVEVFFVDYGNTETVPLSDLRPL 50
Tudor_TDRD1_rpt1 cd20408
first Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; ...
 271-436 9.78e-09

first Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410479  Cd Length: 130  Bit Score: 55.07  E-value: 9.78e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462537572  271 VTVCHINSPGDFYLQlIEGLDILFLLKTIE----EFYKSEDGENLEIlcPVQDQACVAKF-EDGIWYRAKVIELNhwesc 345
Cdd:cd20408      1 GTVTEFKNPGEFYIQ-IYTLEVLESLVKLTsqlkKTYASVNNHKEYI--PEVGEVCVAKYsEDQNWYRALVQTVD----- 72

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462537572  346 wkscIDRTKQQkliiqkpvnsslmltvclshailivkvqikglpghqeveVKYVDFGNTAKITIKDVRKIKDEFLNAPEK 425
Cdd:cd20408     73 ----VQQKKAG---------------------------------------VFYIDYGNEETVPLNRIQPLKKDIELFPPC 109

                          170
                   ....*....|.
gi 2462537572  426 AIKCKLAYIEP 436
Cdd:cd20408    110 AIKCCLANVKP 120
TUDOR pfam00567
Tudor domain;
8-115 1.29e-08

Tudor domain;


Pssm-ID: 425754 [Multi-domain]  Cd Length: 117  Bit Score: 54.28  E-value: 1.29e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462537572    8 VFVSHVIDPCHFYIRKYSQIKDAKVLEKKVNEFCNRSSHLDPSDILELGARIFVSSikNGMWCRGTITELIPIEgrntrk 87
Cdd:pfam00567    5 VVVSHIESPSTFYIQPKSDSKKLEKLTEELQEYYASKPPESLPPAVGDGCVAAFSE--DGKWYRAKITESLDDG------ 76

                           90       100
                   ....*....|....*....|....*...
gi 2462537572   88 pcsptrlfvhevaLIQIFMVDFGNSEVL 115
Cdd:pfam00567   77 -------------LVEVLFIDYGNTETV 91
Tudor_dTUD-like cd20379
Tudor domain found in Drosophila melanogaster maternal protein Tudor (dTUD) and similar ...
 604-652 1.60e-08

Tudor domain found in Drosophila melanogaster maternal protein Tudor (dTUD) and similar proteins; dTUD is required during oogenesis for the formation of primordial germ cells and for normal abdominal segmentation. It contains 11 Tudor domains. The family also includes mitochondrial A-kinase anchor protein 1 (AKAP1) and Tudor domain-containing proteins (TDRDs). AKAP1, also called A-kinase anchor protein 149 kDa (AKAP 149), or dual specificity A-kinase-anchoring protein 1 (D-AKAP-1), or protein kinase A-anchoring protein 1 (PRKA1), or Spermatid A-kinase anchor protein 84 (S-AKAP84), is found in mitochondria and in the endoplasmic reticulum-nuclear envelope where it anchors protein kinases, phosphatases, and a phosphodiesterase. It regulates multiple cellular processes governing mitochondrial homeostasis and cell viability. AKAP1 binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane. TDRDs have diverse biological functions and may contain one or more copies of the Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410450  Cd Length: 50  Bit Score: 51.75  E-value: 1.60e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 2462537572  604 DMHCAVKIQDKNQWRRGQIIRMVTDTLVEVLLYDVGVELVVNVDCLRKL 652
Cdd:cd20379      2 GDLCAAKYEEDGKWYRARVLEVLSNDKVEVFFVDYGNTETVPLSDLRPL 50
TUDOR smart00333
Tudor domain; Domain of unknown function present in several RNA-binding proteins. 10 copies in ...
 867-916 1.60e-08

Tudor domain; Domain of unknown function present in several RNA-binding proteins. 10 copies in the Drosophila Tudor protein. Initial proposal that the survival motor neuron gene product contain a Tudor domain are corroborated by more recent database search techniques such as PSI-BLAST (unpublished).


Pssm-ID: 197660  Cd Length: 57  Bit Score: 51.89  E-value: 1.60e-08
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|.
gi 2462537572   867 WKKGEACAVRGSDTLWYRGKVMEVVG-GAVRVQYLDHGFTEKIPQCHLYPI 916
Cdd:smart00333    3 FKVGDKVAARWEDGEWYRARIVKVDGeQLYEVFFIDYGNEEVVPPSDLRQL 53
Tudor_dTUD-like cd20379
Tudor domain found in Drosophila melanogaster maternal protein Tudor (dTUD) and similar ...
 1122-1170 1.65e-08

Tudor domain found in Drosophila melanogaster maternal protein Tudor (dTUD) and similar proteins; dTUD is required during oogenesis for the formation of primordial germ cells and for normal abdominal segmentation. It contains 11 Tudor domains. The family also includes mitochondrial A-kinase anchor protein 1 (AKAP1) and Tudor domain-containing proteins (TDRDs). AKAP1, also called A-kinase anchor protein 149 kDa (AKAP 149), or dual specificity A-kinase-anchoring protein 1 (D-AKAP-1), or protein kinase A-anchoring protein 1 (PRKA1), or Spermatid A-kinase anchor protein 84 (S-AKAP84), is found in mitochondria and in the endoplasmic reticulum-nuclear envelope where it anchors protein kinases, phosphatases, and a phosphodiesterase. It regulates multiple cellular processes governing mitochondrial homeostasis and cell viability. AKAP1 binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane. TDRDs have diverse biological functions and may contain one or more copies of the Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410450  Cd Length: 50  Bit Score: 51.75  E-value: 1.65e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 2462537572 1122 MPCLAEY-DDGLWYRAKIVAIKEFNplSILVQFVDYGSTAKLTLNRLCQI 1170
Cdd:cd20379      3 DLCAAKYeEDGKWYRARVLEVLSND--KVEVFFVDYGNTETVPLSDLRPL 50
Tudor_TDRD15_rpt5 cd20440
fifth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; ...
 1047-1186 2.90e-08

fifth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the fifth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410511  Cd Length: 127  Bit Score: 53.61  E-value: 2.90e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462537572 1047 SPGELYAVQVKHVVSPNEVYICLDSietsnqsnqhsdtddsgvsgesESESLDEALQRVNKKVEALP-PLTDFRTEMPCL 1125
Cdd:cd20440      7 KVGSEEEVYITHVYSPAKFYCQLDR----------------------NTEILEALMEKIAEISKLFNsQILDNCKTRLCL 64

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2462537572 1126 AEY-DDGLWYRAKIVAIKefNPLSILVQFVDYGSTAKLTLNRLCQIPSH---LMRYPARAIKVLL 1186
Cdd:cd20440     65 AKYfEDGQWYRALAHPVE--SSSHLSVYFVDYGNKQIVEKNEVLPIPDTavdLLLTPMQAIKCCL 127
Tudor_TDRD6_rpt4 cd20423
fourth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; ...
 1117-1192 3.46e-08

fourth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410494  Cd Length: 80  Bit Score: 51.71  E-value: 3.46e-08
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2462537572 1117 DFRTEMPCLAEY-DDGLWYRAKIVAIKEfNPLSILVQFVDYGSTAKLTLNRLCQIPSHLMRYPARAIKVLLAGFKPP 1192
Cdd:cd20423      2 HSLPNPVCLAKYsEDGKWCRALIDNVYE-PVEMVEVTYVDYGNKELVSLKNLRSISEEFLKLKAQAFRCSLYNLIQP 77
Tudor_TDRD6_rpt6 cd20425
sixth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; ...
 558-668 6.21e-08

sixth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the sixth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410496  Cd Length: 115  Bit Score: 52.07  E-value: 6.21e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462537572  558 VHICNVISPEKIYVQWLLTENLLNSLEEKMIAAYENSkwEPVKWE----NDMHCAVKIQDkNQWRRGQIIRMVTDTLVEV 633
Cdd:cd20425      4 VYVSHVNSPSDFYVQLAQDEDELSMISEKLNASKAND--EEVECEslqlGDLICAEYPED-GLWYRAVVKEKIPNNLVSV 80

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 2462537572  634 LLYDVGVELVVNVDCLRKLEENLKTMGRLSLECSL 668
Cdd:cd20425     81 QFIDYGNTSVVQPSKIHRLPKELLSIPALSIHCFL 115
Tudor_AKAP1 cd20407
Tudor domain found in mitochondrial A-kinase anchor protein 1 (AKAP1) and similar proteins; ...
 1124-1191 9.34e-08

Tudor domain found in mitochondrial A-kinase anchor protein 1 (AKAP1) and similar proteins; AKAP1, also called A-kinase anchor protein 149 kDa (AKAP 149), dual specificity A-kinase-anchoring protein 1 (D-AKAP-1), protein kinase A-anchoring protein 1 (PRKA1), or Spermatid A-kinase anchor protein 84 (S-AKAP84), is found in mitochondria and in the endoplasmic reticulum-nuclear envelope, where it anchors protein kinases, phosphatases, and a phosphodiesterase. It regulates multiple cellular processes governing mitochondrial homeostasis and cell viability. AKAP1 binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane. It contains a C-terminal Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410478  Cd Length: 76  Bit Score: 50.28  E-value: 9.34e-08
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2462537572 1124 CLAEYDDGlWYRAKIVAIKEfNPLSILVQFVDYGSTAKLTLNRLCQIPSHLMRYPARAIKVLLAGFKP 1191
Cdd:cd20407     11 CAAPVMNA-WYRAQVVGVFE-ETDEVEIKYLDYGGYERVPVDDLRQIRSDFMTLPFQATECYLANIEP 76
Tudor_TDRD15_rpt2 cd20437
second Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; ...
 558-668 1.13e-07

second Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410508  Cd Length: 120  Bit Score: 51.65  E-value: 1.13e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462537572  558 VHICNVISPEKIYVQWLLTENLLNSLEEKMIAAYE--NSKWEPVKWENDMHCAVKIQDkNQWRRGQIIRMVTDTLVEVLL 635
Cdd:cd20437      7 VKITAAVSPSKFYCQLLSWEPELSKLTTQMTLHYEsvSKELNPSCENFGLLCAAKGKD-GQWHRGFLQQLLPPSQVKVWF 85

                           90       100       110
                   ....*....|....*....|....*....|...
gi 2462537572  636 YDVGVELVVNVDCLRKLEENLKTMGRLSLECSL 668
Cdd:cd20437     86 IDYGNSEAVSSHSVLKLPPDFFSLPLMSFPCSL 118
Tudor_TDRD1_rpt1 cd20408
first Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; ...
 844-946 2.24e-07

first Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410479  Cd Length: 130  Bit Score: 51.22  E-value: 2.24e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462537572  844 ELIKMTNEIQSNLKCLGLLEPYFWKKGEACAVRGS-DTLWYRGKVMEV--VGGAVRVQYLDHGFTEKIPQCHLYPilLYP 920
Cdd:cd20408     24 SLVKLTSQLKKTYASVNNHKEYIPEVGEVCVAKYSeDQNWYRALVQTVdvQQKKAGVFYIDYGNEETVPLNRIQP--LKK 101

                           90       100
                   ....*....|....*....|....*....
gi 2462537572  921 DIPQFC---IPCQLHNTTPVGNVWQPDAI 946
Cdd:cd20408    102 DIELFPpcaIKCCLANVKPPSGSWSEECI 130
Tudor_TDRD6_rpt7 cd20426
seventh Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; ...
 1123-1189 3.15e-07

seventh Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the seventh one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410497  Cd Length: 140  Bit Score: 50.96  E-value: 3.15e-07
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2462537572 1123 PCLAEY-DDGLWYRAKIVAIKEfNPLSilVQFVDYGSTAKLTLNRLCQIPSHLMRYPARAIKVLLAGF 1189
Cdd:cd20426     52 PCIVKYsEDNHWYRALVTKIND-NLVS--VRFVDYGNEEDVVREQVRALPSELLKIPVQAFPCCLSGF 116
Tudor_TDRD11 cd20433
Tudor domain found in Tudor domain-containing protein 11 (TDRD11) and similar proteins; TDRD11, ...
 1095-1175 3.53e-07

Tudor domain found in Tudor domain-containing protein 11 (TDRD11) and similar proteins; TDRD11, also called Staphylococcal nuclease domain-containing protein 1 (SND1), 100 kDa coactivator, EBNA2 coactivator p100, or p100 co-activator, is a multifunctional protein that is reportedly associated with different types of RNA molecules, including mRNA, miRNA, pre-miRNA, and dsRNA. It has been implicated in a number of biological processes in eukaryotic cells, including the cell cycle, DNA damage repair, proliferation, and apoptosis. TDRD11 is overexpressed in multiple cancers and functions as an oncogene. It contains multiple Staphylococcal nuclease (SN) domains and a C-terminal Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410504 [Multi-domain]  Cd Length: 84  Bit Score: 49.22  E-value: 3.53e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462537572 1095 SESLDEALQRVNKKVEALPPLT--------DFrtempCLAEY-DDGLWYRAKIVAIKefNPLSILVQFVDYGSTAKLTLN 1165
Cdd:cd20433      2 GPQLEKLMEKLRFEIASNPPLPgsytprkgDL-----CAAKFvEDGEWYRAKVEKVE--GDKKVHVLYIDYGNREVLPST 74

                           90
                   ....*....|
gi 2462537572 1166 RLCQIPSHLM 1175
Cdd:cd20433     75 RLAALPPAFS 84
Tudor_TDRD6_rpt6 cd20425
sixth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; ...
 269-431 3.56e-07

sixth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the sixth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410496  Cd Length: 115  Bit Score: 50.15  E-value: 3.56e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462537572  269 VSVTVCHINSPGDFYLQLIEGLDilfLLKTIEEFYKSEDGENLEILCP---VQDQACVAKFEDGIWYRAKVIElnhwesc 345
Cdd:cd20425      2 TEVYVSHVNSPSDFYVQLAQDED---ELSMISEKLNASKANDEEVECEslqLGDLICAEYPEDGLWYRAVVKE------- 71

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462537572  346 wkscidrtkqqkliiQKPVNSslmltvclshailivkvqikglpghqeVEVKYVDFGNTAKITIKDVRKIKDEFLNAPEK 425
Cdd:cd20425     72 ---------------KIPNNL---------------------------VSVQFIDYGNTSVVQPSKIHRLPKELLSIPAL 109


                   ....*.
gi 2462537572  426 AIKCKL 431
Cdd:cd20425    110 SIHCFL 115
Tudor_AKAP1 cd20407
Tudor domain found in mitochondrial A-kinase anchor protein 1 (AKAP1) and similar proteins; ...
 393-436 4.74e-07

Tudor domain found in mitochondrial A-kinase anchor protein 1 (AKAP1) and similar proteins; AKAP1, also called A-kinase anchor protein 149 kDa (AKAP 149), dual specificity A-kinase-anchoring protein 1 (D-AKAP-1), protein kinase A-anchoring protein 1 (PRKA1), or Spermatid A-kinase anchor protein 84 (S-AKAP84), is found in mitochondria and in the endoplasmic reticulum-nuclear envelope, where it anchors protein kinases, phosphatases, and a phosphodiesterase. It regulates multiple cellular processes governing mitochondrial homeostasis and cell viability. AKAP1 binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane. It contains a C-terminal Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410478  Cd Length: 76  Bit Score: 48.36  E-value: 4.74e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 2462537572  393 EVEVKYVDFGNTAKITIKDVRKIKDEFLNAPEKAIKCKLAYIEP 436
Cdd:cd20407     33 EVEIKYLDYGGYERVPVDDLRQIRSDFMTLPFQATECYLANIEP 76
Tudor_TDRD15_rpt3 cd20438
third Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; ...
 873-951 5.14e-07

third Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410509  Cd Length: 141  Bit Score: 50.17  E-value: 5.14e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462537572  873 CAVRGSDTLWYRGKVMEVVGGAVRVQYLDHGFTEKIPQCHLYPIL-LYPDIPQFCIPCQLHNTTPVGNVWQPDAIEVLQQ 951
Cdd:cd20438     62 CARYSKDRHYYRAVITEVLDLKVSVYFLDFGNTDTVPFYDVKTLLpEFSELPALAMCCSLAHVFPVEEVWTKNANDFFKK 141
Tudor_TDRD1_rpt2 cd20409
second Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; ...
 1096-1175 6.58e-07

second Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410480  Cd Length: 82  Bit Score: 48.22  E-value: 6.58e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462537572 1096 ESLDEALQRVNKKVEALPPLTDFRTEM--PCLAEY-DDGLWYRAKIVAIKefNPLSILVQFVDYGSTAKLTLNRLCQIPS 1172
Cdd:cd20409      2 RQLAELQESLSAYCKVAPASSDFSPAVgeVCCAQFtEDNQWYRASVLAYS--SEDSVLVGYIDFGNSEEVALSRLRPIPP 79


                   ...
gi 2462537572 1173 HLM 1175
Cdd:cd20409     80 SLL 82
Tudor_TDRD6_rpt6 cd20425
sixth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; ...
 1054-1182 6.69e-07

sixth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the sixth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410496  Cd Length: 115  Bit Score: 49.38  E-value: 6.69e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462537572 1054 VQVKHVVSPNEVYICLDSietsnqsnqhsdtDDSGVSgeSESESLDEALQRVNKKVEALPPLTDfrteMPClAEY-DDGL 1132
Cdd:cd20425      4 VYVSHVNSPSDFYVQLAQ-------------DEDELS--MISEKLNASKANDEEVECESLQLGD----LIC-AEYpEDGL 63

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|
gi 2462537572 1133 WYRAkIVAIKEFNPLsILVQFVDYGSTAKLTLNRLCQIPSHLMRYPARAI 1182
Cdd:cd20425     64 WYRA-VVKEKIPNNL-VSVQFIDYGNTSVVQPSKIHRLPKELLSIPALSI 111
Tudor_TDRD9 cd20431
Tudor domain found in Tudor domain-containing protein 9 (TDRD9) and similar proteins; TDRD9 is ...
 1112-1178 7.66e-07

Tudor domain found in Tudor domain-containing protein 9 (TDRD9) and similar proteins; TDRD9 is an ATP-dependent DEAD-like RNA helicase required during spermatogenesis. It is involved in the biosynthesis of PIWI-interacting RNAs (piRNAs). A recessive deleterious mutation mutation in TDRD9 causes non-obstructive azoospermia in infertile men. TDRD9 contains an N-terminal HrpA-like RNA helicase module and a Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410502  Cd Length: 101  Bit Score: 48.54  E-value: 7.66e-07
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462537572 1112 LPPLTDFRTEMPCLAEYDDGL---WYRAKIVAIkefNPLSILVQFVDYGSTAKLTLNRLCQIPSHLMRYP 1178
Cdd:cd20431     35 VPLTTKPVPNLLCLAPFTDADmkkYYRAKILYV---SGSSAEVFFVDYGNTSQVPSSLLREIPETLLTLP 101
Tudor_TDRD1_rpt3 cd20410
third Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; ...
 1123-1175 7.87e-07

third Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410481 [Multi-domain]  Cd Length: 59  Bit Score: 47.34  E-value: 7.87e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 2462537572 1123 PCLAEY-DDGLWYRAkivAIKE-FNPLSILVQFVDYGSTAKLTLNRLCQIPSHLM 1175
Cdd:cd20410      8 PCCAFFsGDGNWYRA---MVKEiLPGGAVKVHFVDYGNVEEVTLDKLRKITSTFL 59
Tudor_TDRD6_rpt3 cd20422
third Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; ...
 271-444 9.71e-07

third Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410493  Cd Length: 135  Bit Score: 49.43  E-value: 9.71e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462537572  271 VTVCHINSPGDFYLQLIE-GLDILFLLKTIEEFYKSEDGENLEILCPVQDQACVAKFEDGIWYRAkvielnhwescwksc 349
Cdd:cd20422      4 AQVEFVKDPSEFWIRLGEhAVPFSKLMRSMTAFYSQASKLDGVVLKPQPGQLCCAKWKEDRYYRA--------------- 68

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462537572  350 idrtkqqkliiqkpvnsslmltvclshaiLIVKVQIKGlpghqeVEVKYVDFGNTAKITIKDVRKIKDEFLNAPEKAIKC 429
Cdd:cd20422     69 -----------------------------IVTAVKGKM------VEVFLVDRGNTEMVDWYDVKKLLPQFRELPALALKC 113

                          170
                   ....*....|....*
gi 2462537572  430 KLAYIEPYKRTmqWS 444
Cdd:cd20422    114 CLADICPLGER--WS 126
Tudor_TDRD6_rpt5 cd20424
fifth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; ...
 1124-1186 1.11e-06

fifth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the fifth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410495  Cd Length: 126  Bit Score: 49.04  E-value: 1.11e-06
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462537572 1124 CLAEYDDGLWYRAKIVAIKEfnplSILVQFVDYGSTAKLTLNRLCQIPS---HLMRYPARAIKVLL 1186
Cdd:cd20424     65 CLAKYSDQHWYRGIIITNKN----STEVFFVDYGNTEKVEKEDMLPIPSdayELLLLPMQAIKCSL 126
Tudor_TDRD11 cd20433
Tudor domain found in Tudor domain-containing protein 11 (TDRD11) and similar proteins; TDRD11, ...
 847-916 1.21e-06

Tudor domain found in Tudor domain-containing protein 11 (TDRD11) and similar proteins; TDRD11, also called Staphylococcal nuclease domain-containing protein 1 (SND1), 100 kDa coactivator, EBNA2 coactivator p100, or p100 co-activator, is a multifunctional protein that is reportedly associated with different types of RNA molecules, including mRNA, miRNA, pre-miRNA, and dsRNA. It has been implicated in a number of biological processes in eukaryotic cells, including the cell cycle, DNA damage repair, proliferation, and apoptosis. TDRD11 is overexpressed in multiple cancers and functions as an oncogene. It contains multiple Staphylococcal nuclease (SN) domains and a C-terminal Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410504 [Multi-domain]  Cd Length: 84  Bit Score: 47.68  E-value: 1.21e-06
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462537572  847 KMTNEIQSNLKCLGLLEPyfwKKGEACAVRGS-DTLWYRGKVMEVVGGA-VRVQYLDHGFTEKIPQCHLYPI 916
Cdd:cd20433     11 KLRFEIASNPPLPGSYTP---RKGDLCAAKFVeDGEWYRAKVEKVEGDKkVHVLYIDYGNREVLPSTRLAAL 79
Tudor_TDRD15_rpt1 cd20436
first Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; ...
 560-699 4.47e-06

first Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410507  Cd Length: 147  Bit Score: 47.80  E-value: 4.47e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462537572  560 ICNVISPEKIYVQWlltENLLNSLEEKMIAAYENSKWEPVK----WENDMHCAVKIQDKNQWRRGQIIRmVTDTLVEVLL 635
Cdd:cd20436      5 THRVCHPKEVLVKF---QGQYNSICELDYHILQNEIQNATKskssWGVGEFCLVEDTTSGEWYRGRVLE-KIDEKYEVFL 80

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2462537572  636 YDVGVELVVNVDCLRKLEENLKTMGRLSLECSLVDIRPAGGsdKWTATACDCLS----LYLTGAVATI 699
Cdd:cd20436     81 IDRGEVLNVHATNMASASGELFQLPPKAVCGIFANILPIGE--KWSSTAVNYFSsligSQVKGYIQAI 146
Tudor_TDRD1_rpt3 cd20410
third Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; ...
 868-916 5.12e-06

third Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410481 [Multi-domain]  Cd Length: 59  Bit Score: 45.02  E-value: 5.12e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 2462537572  868 KKGEAC-AVRGSDTLWYRGKVMEVV-GGAVRVQYLDHGFTEKIPQCHLYPI 916
Cdd:cd20410      4 IVGEPCcAFFSGDGNWYRAMVKEILpGGAVKVHFVDYGNVEEVTLDKLRKI 54
Tudor_TDRD15_rpt2 cd20437
second Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; ...
 267-432 6.88e-06

second Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410508  Cd Length: 120  Bit Score: 46.64  E-value: 6.88e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462537572  267 TDVSVTVCHINSPGDFYLQLIE-GLDILFLLKTIEEFYKSEDGENLEIlCPVQDQACVAKFEDGIWYRAKVIELnhwesc 345
Cdd:cd20437      3 TTEKVKITAAVSPSKFYCQLLSwEPELSKLTTQMTLHYESVSKELNPS-CENFGLLCAAKGKDGQWHRGFLQQL------ 75

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462537572  346 wkscidrtkqqkliiqkpvnsslmltvclshailivkvqikgLPGHQeVEVKYVDFGNTAKITIKDVRKIKDEFLNAPEK 425
Cdd:cd20437     76 ------------------------------------------LPPSQ-VKVWFIDYGNSEAVSSHSVLKLPPDFFSLPLM 112


                   ....*..
gi 2462537572  426 AIKCKLA 432
Cdd:cd20437    113 SFPCSLS 119
Tudor_TDRD4_rpt2 cd20415
second Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; ...
 853-936 1.15e-05

second Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; TDRD4, also called RING finger protein 17 (RNF17), is a component of the mammalian germ cell nuage and is essential for spermiogenesis. It seems to be involved in the regulation of transcriptional activity of MYC. In vitro, TDRD4 inhibits the DNA-binding activity of Mad-MAX heterodimers. It can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. TDRD4 also acts as a potential cancer/testis antigen in liver cancer. TDRD4 contains a RING finger and five Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410486  Cd Length: 96  Bit Score: 45.12  E-value: 1.15e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462537572  853 QSNLKCLGLLEPYfwkKGEACAVRGSDTLWYRGKVMEVVGG-AVRVQYLDHGFTEKIPQCHLYPIllyPD----IPQFCI 927
Cdd:cd20415     14 EGDDGGLEILCPV---QGQACVALFEDGAWYRARIIGLPGHrEVEVKYVDFGNTATVTIKHVRKI---KDdflsLPEKAR 87


                   ....*....
gi 2462537572  928 PCQLHNTTP 936
Cdd:cd20415     88 ECRLAFIEP 96
Tudor_ZGPAT cd20384
Tudor domain found in zinc finger CCCH-type with G patch domain-containing protein (ZGPAT) and ...
 1124-1162 1.21e-05

Tudor domain found in zinc finger CCCH-type with G patch domain-containing protein (ZGPAT) and similar proteins; ZGPAT, also called ZIP, G patch domain-containing protein 6 (GPATC6), GPATCH6, zinc finger CCCH domain-containing protein 9 (ZC3HDC9), ZC3H9, or zinc finger and G patch domain-containing protein, is a transcription repressor that specifically binds the 5'-GGAG[GA]A[GA]A-3' consensus sequence. It represses transcription by recruiting the chromatin multiprotein complex NuRD to target promoters. It contains one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410455  Cd Length: 55  Bit Score: 43.75  E-value: 1.21e-05
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 2462537572 1124 CLAEYDDGLWYRAKIVAIKEFNplSILVQFVDYGSTAKL 1162
Cdd:cd20384     11 CLAKYDDGLWYPATVTDIDEDG--KYTVKFDSYGEVAVV 47
TUDOR smart00333
Tudor domain; Domain of unknown function present in several RNA-binding proteins. 10 copies in ...
 598-654 1.44e-05

Tudor domain; Domain of unknown function present in several RNA-binding proteins. 10 copies in the Drosophila Tudor protein. Initial proposal that the survival motor neuron gene product contain a Tudor domain are corroborated by more recent database search techniques such as PSI-BLAST (unpublished).


Pssm-ID: 197660  Cd Length: 57  Bit Score: 43.80  E-value: 1.44e-05
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*..
gi 2462537572   598 PVKWENDMhCAVKIQDkNQWRRGQIIRMVTDTLVEVLLYDVGVELVVNVDCLRKLEE 654
Cdd:smart00333    1 PTFKVGDK-VAARWED-GEWYRARIVKVDGEQLYEVFFIDYGNEEVVPPSDLRQLPE 55
Tudor_TDRD1_rpt4 cd20411
fourth Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; ...
 864-931 1.88e-05

fourth Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410482  Cd Length: 116  Bit Score: 45.13  E-value: 1.88e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462537572  864 PYFWKKGEACAVR-GSDTLWYRGKVMEVVGGAVRVQYLDHGFTEKIPQCHLYPIL-LYPDIPQFCIPCQL 931
Cdd:cd20411     45 QFRPRIGDACCARfTGDKNWYRAVVLETSDSEVKVLYADYGNTETLPLSRILPITkSHLELPFQIIRCSL 114
Tudor_TDRD4_rpt5 cd20418
fifth Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; ...
 322-436 2.53e-05

fifth Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; TDRD4, also called RING finger protein 17 (RNF17), is a component of the mammalian germ cell nuage and is essential for spermiogenesis. It seems to be involved in the regulation of transcriptional activity of MYC. In vitro, TDRD4 inhibits the DNA-binding activity of Mad-MAX heterodimers. It can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. TDRD4 also acts as a potential cancer/testis antigen in liver cancer. TDRD4 contains a RING finger and five Tudor domains. This model corresponds to the fifth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410489  Cd Length: 105  Bit Score: 44.32  E-value: 2.53e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462537572  322 CVAKFEDGIWYRAKVIELNHWEscwkscidrtkqqkliiqkPVnsslmltvclshailivkvqikglpghqEVEVKYVDF 401
Cdd:cd20418     10 CLAEYSDGKWYRAKLLSILEFN-------------------PV----------------------------KILVRHVDY 42

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 2462537572  402 GNTAKITIKDVRKIKDEFLNAPEKAIKCKLAYIEP 436
Cdd:cd20418     43 GSTAALPTSRLRQIPAELMQYPCQAIKVKLAGFKP 77
Tudor_TDRD6_rpt5 cd20424
fifth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; ...
 271-431 2.85e-05

fifth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the fifth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410495  Cd Length: 126  Bit Score: 44.80  E-value: 2.85e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462537572  271 VTVCHINSPGDFYLQLIEGLDILFLLK-TIEEFykSEDGENLEilCPVQDQA-CVAKFEDGIWYRAKVIELNhwescwks 348
Cdd:cd20424     16 VYITYVNDPWTFYCQLARNAGVLDQLAsAISRL--SSEIRKLE--LSVNPGTlCLAKYSDQHWYRGIIITNK-------- 83

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462537572  349 cidrtkqqkliiqkpvnsslmltvclshailivkvqikglpghQEVEVKYVDFGNTAKITIKDVRKIKD---EFLNAPEK 425
Cdd:cd20424     84 -------------------------------------------NSTEVFFVDYGNTEKVEKEDMLPIPSdayELLLLPMQ 120


                   ....*.
gi 2462537572  426 AIKCKL 431
Cdd:cd20424    121 AIKCSL 126
Tudor_dTUD-like cd20379
Tudor domain found in Drosophila melanogaster maternal protein Tudor (dTUD) and similar ...
 319-415 5.38e-05

Tudor domain found in Drosophila melanogaster maternal protein Tudor (dTUD) and similar proteins; dTUD is required during oogenesis for the formation of primordial germ cells and for normal abdominal segmentation. It contains 11 Tudor domains. The family also includes mitochondrial A-kinase anchor protein 1 (AKAP1) and Tudor domain-containing proteins (TDRDs). AKAP1, also called A-kinase anchor protein 149 kDa (AKAP 149), or dual specificity A-kinase-anchoring protein 1 (D-AKAP-1), or protein kinase A-anchoring protein 1 (PRKA1), or Spermatid A-kinase anchor protein 84 (S-AKAP84), is found in mitochondria and in the endoplasmic reticulum-nuclear envelope where it anchors protein kinases, phosphatases, and a phosphodiesterase. It regulates multiple cellular processes governing mitochondrial homeostasis and cell viability. AKAP1 binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane. TDRDs have diverse biological functions and may contain one or more copies of the Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410450  Cd Length: 50  Bit Score: 41.73  E-value: 5.38e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462537572  319 DQACVAKFE-DGIWYRAKVIELNHwescwkscidrtkqqkliiqkpvnsslmltvclshailivkvqikglpgHQEVEVK 397
Cdd:cd20379      2 GDLCAAKYEeDGKWYRARVLEVLS-------------------------------------------------NDKVEVF 32

                           90
                   ....*....|....*...
gi 2462537572  398 YVDFGNTAKITIKDVRKI 415
Cdd:cd20379     33 FVDYGNTETVPLSDLRPL 50
Tudor_TDRD6_rpt3 cd20422
third Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; ...
 602-687 6.88e-05

third Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410493  Cd Length: 135  Bit Score: 44.04  E-value: 6.88e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462537572  602 ENDMHCAVKIQDKNQWRrgQIIRMVTDTLVEVLLYDVGVELVVNVDCLRKLEENLKTMGRLSLECSLVDIRPAGgsDKWT 681
Cdd:cd20422     51 QPGQLCCAKWKEDRYYR--AIVTAVKGKMVEVFLVDRGNTEMVDWYDVKKLLPQFRELPALALKCCLADICPLG--ERWS 126


                   ....*.
gi 2462537572  682 ATACDC 687
Cdd:cd20422    127 PEAISA 132
Tudor_TDRD1_rpt1 cd20408
first Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; ...
 1095-1192 6.94e-05

first Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410479  Cd Length: 130  Bit Score: 43.90  E-value: 6.94e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462537572 1095 SESLDEALQRVNKKVEALPPLTDFrtempCLAEY-DDGLWYRAKIVAIKEFNPLSiLVQFVDYGSTAKLTLNRLCQIPSH 1173
Cdd:cd20408     29 TSQLKKTYASVNNHKEYIPEVGEV-----CVAKYsEDQNWYRALVQTVDVQQKKA-GVFYIDYGNEETVPLNRIQPLKKD 102

                           90
                   ....*....|....*....
gi 2462537572 1174 LMRYPARAIKVLLAGFKPP 1192
Cdd:cd20408    103 IELFPPCAIKCCLANVKPP 121
Tudor_TDRD15_rpt6 cd20441
sixth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; ...
 278-432 8.41e-05

sixth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the sixth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410512  Cd Length: 108  Bit Score: 43.19  E-value: 8.41e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462537572  278 SPGDFYLQLIEglDILFLLKTIEEF--YKSEDGENLEILCPVQDqACVAKF-EDGIWYRAKVielnhwescwkscidrtk 354
Cdd:cd20441      1 SPSRFFIQLSE--DEKVILQLAEELneTSEKSRENAAVKLKVGD-LVAAEYdEDLALYRAVI------------------ 59

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2462537572  355 qqkliiqkpvnsslmLTVClshailivkvqikglpGHQEVEVKYVDFGNTAKITIKDVRKIKDEFLNAPEKAIKCKLA 432
Cdd:cd20441     60 ---------------TAVL----------------PGKSFKVEFIDYGNTAVVDKSNIYTLQEKFLSLPRLSIPCSLS 106
Tudor_TDRD6_rpt6 cd20425
sixth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; ...
 873-931 9.47e-05

sixth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the sixth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410496  Cd Length: 115  Bit Score: 43.21  E-value: 9.47e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462537572  873 CAVRGSDTLWYRGKVME-VVGGAVRVQYLDHGFTEKIPQCHLY---PILLypDIPQFCIPCQL 931
Cdd:cd20425     55 CAEYPEDGLWYRAVVKEkIPNNLVSVQFIDYGNTSVVQPSKIHrlpKELL--SIPALSIHCFL 115
Tudor_TDRD15_rpt6 cd20441
sixth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; ...
 1093-1188 9.92e-05

sixth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the sixth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410512  Cd Length: 108  Bit Score: 42.81  E-value: 9.92e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462537572 1093 SESES----LDEALQRVNKKVEALPpLTDFRTEMPCLAEYD-DGLWYRAKIVAIKEFNplSILVQFVDYGSTAKLTLNRL 1167
Cdd:cd20441     10 SEDEKvilqLAEELNETSEKSRENA-AVKLKVGDLVAAEYDeDLALYRAVITAVLPGK--SFKVEFIDYGNTAVVDKSNI 86

                           90       100
                   ....*....|....*....|.
gi 2462537572 1168 CQIPSHLMRYPARAIKVLLAG 1188
Cdd:cd20441     87 YTLQEKFLSLPRLSIPCSLSG 107
Tudor_TDRD6_rpt3 cd20422
third Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; ...
 861-946 1.12e-04

third Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410493  Cd Length: 135  Bit Score: 43.27  E-value: 1.12e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462537572  861 LLEPyfwKKGEACAVRGSDTLWYRGKVMEVVGGAVRVQYLDHGFTEKIPQCHLYPILL-YPDIPQFCIPCQLHNTTPVGN 939
Cdd:cd20422     47 VLKP---QPGQLCCAKWKEDRYYRAIVTAVKGKMVEVFLVDRGNTEMVDWYDVKKLLPqFRELPALALKCCLADICPLGE 123


                   ....*..
gi 2462537572  940 VWQPDAI 946
Cdd:cd20422    124 RWSPEAI 130
Tudor_TDRD15_rpt2 cd20437
second Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; ...
 841-931 1.14e-04

second Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410508  Cd Length: 120  Bit Score: 43.18  E-value: 1.14e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462537572  841 SEFELIKMTNEI----QSNLKCLGLLEPYFwkkGEACAVRGSDTLWYRGKVMEV-VGGAVRVQYLDHGFTEKIPQCHLYP 915
Cdd:cd20437     25 WEPELSKLTTQMtlhyESVSKELNPSCENF---GLLCAAKGKDGQWHRGFLQQLlPPSQVKVWFIDYGNSEAVSSHSVLK 101

                           90
                   ....*....|....*....
gi 2462537572  916 ilLYPD---IPQFCIPCQL 931
Cdd:cd20437    102 --LPPDffsLPLMSFPCSL 118
Tudor_TDRD15_rpt7 cd20442
seventh Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; ...
 558-666 1.20e-04

seventh Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the seventh one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410513  Cd Length: 160  Bit Score: 43.87  E-value: 1.20e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462537572  558 VHICNVISPEKIYVQWLLTENLLNSLEEKMIAAYENSKWEPVKW-ENDMHCAVKIQDKNQWRRGQIIRMVTDTL-VEVLL 635
Cdd:cd20442      6 GTLLSVSKNGTFYVRLLRNSEQLTDLESLIAKEAKKCKFVPVEDiKEGLECLAKSKKNLKWYRAVVEHLYPETEkMLVFF 85

                           90       100       110
                   ....*....|....*....|....*....|.
gi 2462537572  636 YDVGVELVVNVDCLRKLEENLKTMGRLSLEC 666
Cdd:cd20442     86 VDHGITEVVSMGNIKQLSNDLLQIPRQAVLC 116
Tudor_TDRD6_rpt3 cd20422
third Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; ...
 1052-1212 2.28e-04

third Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410493  Cd Length: 135  Bit Score: 42.50  E-value: 2.28e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462537572 1052 YAVQVKHVVSPNEVYIcldsiETSNQSNQHSDTDDSGVSGESESESLDEALQRvnkkvealPPLTDFrtempCLAEYDDG 1131
Cdd:cd20422      2 YDAQVEFVKDPSEFWI-----RLGEHAVPFSKLMRSMTAFYSQASKLDGVVLK--------PQPGQL-----CCAKWKED 63

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462537572 1132 LWYRAKIVAIKEfnpLSILVQFVDYGSTAKLTLNRLCQIPSHLMRYPARAIKVLLAgfkpplrDLGetriPYCPKWSMEA 1211
Cdd:cd20422     64 RYYRAIVTAVKG---KMVEVFLVDRGNTEMVDWYDVKKLLPQFRELPALALKCCLA-------DIC----PLGERWSPEA 129


                   .
gi 2462537572 1212 L 1212
Cdd:cd20422    130 I 130
Tudor_TDRD6_rpt2 cd20421
second Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; ...
 868-932 2.67e-04

second Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410492  Cd Length: 130  Bit Score: 42.03  E-value: 2.67e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2462537572  868 KKGEACAVRGSDTLWYRGKVMEVVGG--AVRVQYLDHGFTEKIPQCHLYPILL-YPDIPQFCIPCQLH 932
Cdd:cd20421     62 KLGSPCAARGSDGRWYRAVLQQVFSAnrVVEVLHVDYGRKEVVSVSNLRYLAPeYFRMPVVTYPCALF 129
Tudor_TDRD15_rpt5 cd20440
fifth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; ...
 2-127 3.22e-04

fifth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the fifth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410511  Cd Length: 127  Bit Score: 42.06  E-value: 3.22e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462537572    2 CSSAELVFVSHVIDPCHFYIRKYSQIKDAKVLEKKVNEFCN--RSSHLDPSDILELGARIFvssiKNGMWCRGTItelIP 79
Cdd:cd20440      8 VGSEEEVYITHVYSPAKFYCQLDRNTEILEALMEKIAEISKlfNSQILDNCKTRLCLAKYF----EDGQWYRALA---HP 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*...
gi 2462537572   80 IEgrntrkpcSPTRLfvhevaliQIFMVDFGNSEVlivtgVVDTHVRP 127
Cdd:cd20440     81 VE--------SSSHL--------SVYFVDYGNKQI-----VEKNEVLP 107
Tudor_TDRD1_rpt1 cd20408
first Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; ...
 565-685 3.36e-04

first Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410479  Cd Length: 130  Bit Score: 41.97  E-value: 3.36e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462537572  565 SPEKIYVQWLLTENL--LNSLEEKMIAAYENS----KWEPVKWENdmhCAVKIQDKNQWRRGQII-RMVTDTLVEVLLYD 637
Cdd:cd20408      8 NPGEFYIQIYTLEVLesLVKLTSQLKKTYASVnnhkEYIPEVGEV---CVAKYSEDQNWYRALVQtVDVQQKKAGVFYID 84

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*...
gi 2462537572  638 VGVELVVNVDCLRKLEENLKTMGRLSLECSLVDIRPAGGSdkWTATAC 685
Cdd:cd20408     85 YGNEETVPLNRIQPLKKDIELFPPCAIKCCLANVKPPSGS--WSEECI 130
Tudor_SMN_SPF30-like cd21182
Tudor domain found in survival motor neuron protein (SMN), motor neuron-related-splicing ...
 1122-1170 5.04e-04

Tudor domain found in survival motor neuron protein (SMN), motor neuron-related-splicing factor 30 (SPF30), and similar proteins; This group contains SMN, SPF30, Tudor domain-containing protein 3 (TDRD3), DNA excision repair protein ERCC-6-like 2 (ERCC6L2), and similar proteins. SMN, also called component of gems 1, or Gemin-1, is part of a multimeric SMN complex that includes spliceosomal Sm core proteins and plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. SPF30, also called 30 kDa splicing factor SMNrp, SMN-related protein, or survival motor neuron domain-containing protein 1 (SMNDC1), is an essential pre-mRNA splicing factor required for assembly of the U4/U5/U6 tri-small nuclear ribonucleoprotein into the spliceosome. TDRD3 is a scaffolding protein that specifically recognizes and binds dimethylarginine-containing proteins. ERCC6L2, also called DNA repair and recombination protein RAD26-like (RAD26L), may be involved in early DNA damage response. It regulates RNA Pol II-mediated transcription via its interaction with DNA-dependent protein kinase (DNA-PK) to resolve R loops and minimize transcription-associated genome instability. Members of this group contain a single Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410549  Cd Length: 50  Bit Score: 39.16  E-value: 5.04e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 2462537572 1122 MPCLAEY-DDGLWYRAKIVAIKEfNPLSILVQFVDYGSTAKLTLNRLCQI 1170
Cdd:cd21182      2 DKCLAPYsDDGKYYEATIEEITE-ESDTATVVFDGYGNSEEVPLSDLKPL 50
Tudor_TDRD6_rpt4 cd20423
fourth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; ...
 392-431 5.33e-04

fourth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410494  Cd Length: 80  Bit Score: 40.16  E-value: 5.33e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 2462537572  392 QEVEVKYVDFGNTAKITIKDVRKIKDEFLNAPEKAIKCKL 431
Cdd:cd20423     32 EMVEVTYVDYGNKELVSLKNLRSISEEFLKLKAQAFRCSL 71
Tudor_TDRD7_rpt1 cd20427
first Tudor domain found in Tudor domain-containing protein 7 (TDRD7) and similar proteins; ...
 394-437 5.54e-04

first Tudor domain found in Tudor domain-containing protein 7 (TDRD7) and similar proteins; TDRD7, also called PCTAIRE2-binding protein, or Tudor repeat associator with PCTAIRE-2 (Trap), is a component of specific cytoplasmic RNA granules involved in post-transcriptional regulation of specific genes: probably acts by binding to specific mRNAs and regulating their translation. It is required for lens transparency during lens development, by regulating translation of genes such as CRYBB3 and HSPB1 in the developing lens. It is also essential for dynamic ribonucleoprotein (RNP) remodeling of chromatoid bodies during spermatogenesis. TDRD7 contains three Tudor domains. The model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410498  Cd Length: 98  Bit Score: 40.49  E-value: 5.54e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 2462537572  394 VEVKYVDFGNTAKITIKDVRKIKDEFLNAPEKAIKCKLAYIEPY 437
Cdd:cd20427     51 VKVYYVDHGFSEVVERSKLFKLNKQFYSLPFQATKCKLAGLEPF 94
Tudor_TDRD7_rpt2 cd20428
second Tudor domain found in Tudor domain-containing protein 7 (TDRD7) and similar proteins; ...
 1124-1191 5.80e-04

second Tudor domain found in Tudor domain-containing protein 7 (TDRD7) and similar proteins; TDRD7, also called PCTAIRE2-binding protein, or Tudor repeat associator with PCTAIRE-2 (Trap), is a component of specific cytoplasmic RNA granules involved in post-transcriptional regulation of specific genes: probably acts by binding to specific mRNAs and regulating their translation. It is required for lens transparency during lens development, by regulating translation of genes such as CRYBB3 and HSPB1 in the developing lens. It is also essential for dynamic ribonucleoprotein (RNP) remodeling of chromatoid bodies during spermatogenesis. TDRD7 contains three Tudor domains. The model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410499  Cd Length: 140  Bit Score: 41.28  E-value: 5.80e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462537572 1124 CLAEYDdGLWYRAKIVAIKEFNPLSilVQFVDYGSTAKLTLNRLCQIPSHLMR----YPARAIKVLLAGFKP 1191
Cdd:cd20428     58 CLARYK-GKWARVEITNVHSSRALD--VHFLDTGTVASVKVSELREIPPPFLRelisIPPQALKCCLADLPL 126
Tudor_TDRD1_rpt4 cd20411
fourth Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; ...
 393-432 6.01e-04

fourth Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410482  Cd Length: 116  Bit Score: 40.89  E-value: 6.01e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 2462537572  393 EVEVKYVDFGNTAKITIKDVRKIKDEFLNAPEKAIKCKLA 432
Cdd:cd20411     76 EVKVLYADYGNTETLPLSRILPITKSHLELPFQIIRCSLA 115
Tudor_TDRD15_rpt1 cd20436
first Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; ...
 842-956 6.35e-04

first Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410507  Cd Length: 147  Bit Score: 41.64  E-value: 6.35e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462537572  842 EFELIKMTNEIQSNLKclgllEPYFWKKGEACAVRGSDT-LWYRGKVMEVVGGAVRVQYLDHGFTEKIPQCHLYPI---L 917
Cdd:cd20436     27 ELDYHILQNEIQNATK-----SKSSWGVGEFCLVEDTTSgEWYRGRVLEKIDEKYEVFLIDRGEVLNVHATNMASAsgeL 101

                           90       100       110
                   ....*....|....*....|....*....|....*....
gi 2462537572  918 LypDIPQFCIPCQLHNTTPVGNVWQPDAIEVLQQLLSKR 956
Cdd:cd20436    102 F--QLPPKAVCGIFANILPIGEKWSSTAVNYFSSLIGSQ 138
Tudor_TDRD12_rpt2 cd20435
second Tudor domain found in Tudor domain-containing protein 12 (TDRD12) and similar proteins; ...
 868-914 7.71e-04

second Tudor domain found in Tudor domain-containing protein 12 (TDRD12) and similar proteins; TDRD12, also called ES cell-associated transcript 8 protein (ECAT8), is a putative ATP-dependent DEAD-like RNA helicase that is essential for germ cell development and maintenance. It acts as a unique piRNA biogenesis factor essential for secondary PIWI interacting RNA (piRNA) biogenesis. TDRD12 contains two Tudor domains, one at the N-terminus and the other at the C-terminal end. The model corresponds to the second/C-terminal one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410506  Cd Length: 134  Bit Score: 41.08  E-value: 7.71e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 2462537572  868 KKGEACAVRGSDTLWYRGKVMEVV-----GGA--VRVQYLDHGFTEKIPQCHLY 914
Cdd:cd20435     51 KVGDLCAVEDENNLYHRVKVLEITekddkTKPreVLVKFIDEGRVETVVVSQLL 104
Tudor_TDRD6_rpt7 cd20426
seventh Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; ...
 276-432 8.27e-04

seventh Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the seventh one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410497  Cd Length: 140  Bit Score: 40.95  E-value: 8.27e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462537572  276 INSPGDFYLQL-IEGLDilFLLKTIEEFYKSEDGENLEILCPVQDQACVAKF-EDGIWYRAKVielnhwescwkscidrt 353
Cdd:cd20426      8 VDSPEYFWCQFaTEKIQ--CLAVKVQEAGEQVADRGNFIPSIYVGDPCIVKYsEDNHWYRALV----------------- 68

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2462537572  354 kqqkliiqKPVNSSLmltvclshailivkvqikglpghqeVEVKYVDFGNTAKITIKDVRKIKDEFLNAPEKAIKCKLA 432
Cdd:cd20426     69 --------TKINDNL-------------------------VSVRFVDYGNEEDVVREQVRALPSELLKIPVQAFPCCLS 114
Tudor_TDRD6_rpt2 cd20421
second Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; ...
 269-431 8.63e-04

second Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410492  Cd Length: 130  Bit Score: 40.87  E-value: 8.63e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462537572  269 VSVTVCHINSPGDFYLQL-IEGLDILFLLKTIEEFYKSEDGENLEILCPVQDQACVAKFEDGIWYRAKVIELnhwescwk 347
Cdd:cd20421     13 ETVVVTEVTDPHRIFCQLrSLSQELKRLSESMHQYYEGRVGSGYETRPEKLGSPCAARGSDGRWYRAVLQQV-------- 84

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462537572  348 scidrtkqqkliiqkpvnsslmltvclshailivkvqikgLPGHQEVEVKYVDFGNTAKITIKDVRKIKDEFLNAPEKAI 427
Cdd:cd20421     85 ----------------------------------------FSANRVVEVLHVDYGRKEVVSVSNLRYLAPEYFRMPVVTY 124


                   ....
gi 2462537572  428 KCKL 431
Cdd:cd20421    125 PCAL 128
Tudor_TDRD7_rpt1 cd20427
first Tudor domain found in Tudor domain-containing protein 7 (TDRD7) and similar proteins; ...
 1096-1191 1.02e-03

first Tudor domain found in Tudor domain-containing protein 7 (TDRD7) and similar proteins; TDRD7, also called PCTAIRE2-binding protein, or Tudor repeat associator with PCTAIRE-2 (Trap), is a component of specific cytoplasmic RNA granules involved in post-transcriptional regulation of specific genes: probably acts by binding to specific mRNAs and regulating their translation. It is required for lens transparency during lens development, by regulating translation of genes such as CRYBB3 and HSPB1 in the developing lens. It is also essential for dynamic ribonucleoprotein (RNP) remodeling of chromatoid bodies during spermatogenesis. TDRD7 contains three Tudor domains. The model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410498  Cd Length: 98  Bit Score: 39.72  E-value: 1.02e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462537572 1096 ESLDEALQRVNKKVEALPPLTDFRTEMPCLAEYDDGLWYRAKIVAIKEfnpLSILVQFVDYGSTAKLTLNRLCQIPSHLM 1175
Cdd:cd20427      1 EQMEDEMKEFYSKSSTAMCLRSPSVGQLVAVKAEEDAWLRAQVIEVEE---DKVKVYYVDHGFSEVVERSKLFKLNKQFY 77

                           90
                   ....*....|....*.
gi 2462537572 1176 RYPARAIKVLLAGFKP 1191
Cdd:cd20427     78 SLPFQATKCKLAGLEP 93
Tudor_AtTudor1-like cd20443
Tudor domain found in Arabidopsis thaliana ribonuclease Tudor 1 (AtTudor1), ribonuclease Tudor ...
 280-436 1.09e-03

Tudor domain found in Arabidopsis thaliana ribonuclease Tudor 1 (AtTudor1), ribonuclease Tudor 2 (AtTudor2), and similar proteins; The family includes AtTudor1 (also called Tudor-SN protein 1) and AtTudor2 (also called Tudor-SN protein 2 or 100 kDa coactivator-like protein). They are cytoprotective ribonucleases (RNases) required for resistance to abiotic stresses, acting as positive regulators of mRNA decapping during stress. Members of this family contain one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410514 [Multi-domain]  Cd Length: 117  Bit Score: 40.14  E-value: 1.09e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462537572  280 GDFYLQLIEGLDILFLLKTIEEfYKSEDGENLE-ILCPVQDQACVAKFE-DGIWYRAKVIElnhwescwkscidRTKQqk 357
Cdd:cd20443      2 GRFYVQVVSDQRLSSIQQQLEG-LSLKDKANPPgGFNPKKGELVLAQFSaDNSWNRAMVVN-------------APRQ-- 65

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2462537572  358 liiqkPVNSslmltvclshailivkvqikglpGHQEVEVKYVDFGNTAKITIKDVRKIKDEFLNAPEKAIKCKLAYIEP 436
Cdd:cd20443     66 -----GTQS-----------------------PKDEYEVFYIDYGNQETVPLSALRPLDPSVSSAPGLAQLCSLAHIKV 116
Tudor_TDRD7_rpt3 cd20429
third Tudor domain found in Tudor domain-containing protein 7 (TDRD7) and similar proteins; ...
 580-654 1.44e-03

third Tudor domain found in Tudor domain-containing protein 7 (TDRD7) and similar proteins; TDRD7, also called PCTAIRE2-binding protein, or Tudor repeat associator with PCTAIRE-2 (Trap), is a component of specific cytoplasmic RNA granules involved in post-transcriptional regulation of specific genes: probably acts by binding to specific mRNAs and regulating their translation. It is required for lens transparency during lens development, by regulating translation of genes such as CRYBB3 and HSPB1 in the developing lens. It is also essential for dynamic ribonucleoprotein (RNP) remodeling of chromatoid bodies during spermatogenesis. TDRD7 contains three Tudor domains. The model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410500  Cd Length: 91  Bit Score: 39.01  E-value: 1.44e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2462537572  580 LNSLEEKMIAAYENSKWEPVKWENDMHCAVKIQdkNQWRRGQIIRMVTDTLVEVLLYDVGVELVVNVDCLRKLEE 654
Cdd:cd20429      9 LEVLMEEMILYYNKTEERPVAIEKNKVYAAKIE--NNWYRVLVKGILTNGLVSVYELDYGKHELVSIRKVQPLIE 81
Tudor_TDRD7_rpt1 cd20427
first Tudor domain found in Tudor domain-containing protein 7 (TDRD7) and similar proteins; ...
 847-926 2.46e-03

first Tudor domain found in Tudor domain-containing protein 7 (TDRD7) and similar proteins; TDRD7, also called PCTAIRE2-binding protein, or Tudor repeat associator with PCTAIRE-2 (Trap), is a component of specific cytoplasmic RNA granules involved in post-transcriptional regulation of specific genes: probably acts by binding to specific mRNAs and regulating their translation. It is required for lens transparency during lens development, by regulating translation of genes such as CRYBB3 and HSPB1 in the developing lens. It is also essential for dynamic ribonucleoprotein (RNP) remodeling of chromatoid bodies during spermatogenesis. TDRD7 contains three Tudor domains. The model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410498  Cd Length: 98  Bit Score: 38.56  E-value: 2.46e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462537572  847 KMTNEIQSNLKCLGLLEPyfwKKGEACAVRGSDTLWYRGKVMEVVGGAVRVQYLDHGFTEKIPQCHLYPILlypdiPQFC 926
Cdd:cd20427      6 EMKEFYSKSSTAMCLRSP---SVGQLVAVKAEEDAWLRAQVIEVEEDKVKVYYVDHGFSEVVERSKLFKLN-----KQFY 77
Tudor_vreteno-like_rpt1 cd20444
first Tudor domain found in Drosophila melanogaster protein vreteno and similar proteins; ...
 1122-1174 2.72e-03

first Tudor domain found in Drosophila melanogaster protein vreteno and similar proteins; Vreteno is a gonad-specific protein essential for germline development to repress transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process in both germline and somatic gonadal tissues by mediating the repression of transposable elements during meiosis. Vreteno contains two Tudor domains. The model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410515  Cd Length: 55  Bit Score: 37.28  E-value: 2.72e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 2462537572 1122 MPCLAEYDdGLWYRAKIVAIKEFNPlSILVQFVDYGSTAKLTLNRLCQIPSHL 1174
Cdd:cd20444      5 QMVIAKFD-GNHYRAIVLRVLNPDL-KILVRFVDFGNVEVMKLENLYECPEYL 55
Tudor_TDRD15_rpt3 cd20438
third Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; ...
 393-436 2.85e-03

third Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410509  Cd Length: 141  Bit Score: 39.38  E-value: 2.85e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 2462537572  393 EVEVKYVDFGNTAKITIKDVRKIKDEFLNAPEKAIKCKLAYIEP 436
Cdd:cd20438     83 KVSVYFLDFGNTDTVPFYDVKTLLPEFSELPALAMCCSLAHVFP 126
Tudor_TDRD15_rpt4 cd20439
fourth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; ...
 1124-1189 2.99e-03

fourth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410510  Cd Length: 125  Bit Score: 39.01  E-value: 2.99e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2462537572 1124 CLAEY-DDGLWYRAKIVaiKEFNPLSILVQFVDYGSTAKLTLNRLCQIPSHLMRYPARAIKVLLAGF 1189
Cdd:cd20439     61 CVAKYsKDGKWYRAAVL--KQVSAKEVDVIFVDYGNQERVLISDLRAIKPQFLLLEGQAFRCSLNNF 125
TUDOR smart00333
Tudor domain; Domain of unknown function present in several RNA-binding proteins. 10 copies in ...
 320-419 3.01e-03

Tudor domain; Domain of unknown function present in several RNA-binding proteins. 10 copies in the Drosophila Tudor protein. Initial proposal that the survival motor neuron gene product contain a Tudor domain are corroborated by more recent database search techniques such as PSI-BLAST (unpublished).


Pssm-ID: 197660  Cd Length: 57  Bit Score: 37.25  E-value: 3.01e-03
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462537572   320 QACVAKFEDGIWYRAKVIElnhwescwkscIDRTkqqkliiqkpvnsslmltvclshailivkvqikglpghQEVEVKYV 399
Cdd:smart00333    7 DKVAARWEDGEWYRARIVK-----------VDGE--------------------------------------QLYEVFFI 37

                            90       100
                    ....*....|....*....|
gi 2462537572   400 DFGNTAKITIKDVRKIKDEF 419
Cdd:smart00333   38 DYGNEEVVPPSDLRQLPEEL 57
Tudor_TDRD2 cd20412
Tudor domain found in Tudor domain-containing protein 2 (TDRD2) and similar proteins; TDRD2, ...
 1129-1182 4.75e-03

Tudor domain found in Tudor domain-containing protein 2 (TDRD2) and similar proteins; TDRD2, also called Tudor and KH domain-containing protein (TDRKH), participates in the primary piwi-interacting RNA (piRNA) biogenesis pathway and is required during spermatogenesis to repress transposable elements and prevent their mobilization, which is essential for germline integrity. The family also includes the TDRD2 homolog found in Drosophila melanogaster (dTDRKH), which is also called partner of PIWIs protein, or PAPI, and is involved in Zucchini-mediated piRNA 3'-end maturation. TDRD2 contains two KH domains and one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410483  Cd Length: 95  Bit Score: 37.66  E-value: 4.75e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 2462537572 1129 DDGLWYRAKIVAIKEfnPLSILVQFVDYGSTAKLTLNRLCQIPSHLMRYPARAI 1182
Cdd:cd20412     41 HDGSWYRARVLGFLE--NGNLDLYFVDYGDSGYVPLEDLRALRSDFLSLPFQAI 92
Tudor_TDRD1_rpt4 cd20411
fourth Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; ...
 1124-1188 4.80e-03

fourth Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410482  Cd Length: 116  Bit Score: 38.20  E-value: 4.80e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462537572 1124 CLAEYD-DGLWYRAKIVAIKEfnpLSILVQFVDYGSTAKLTLNRLCQIPSHLMRYPARAIKVLLAG 1188
Cdd:cd20411     54 CCARFTgDKNWYRAVVLETSD---SEVKVLYADYGNTETLPLSRILPITKSHLELPFQIIRCSLAG 116
Tudor_TDRD5 cd20419
Tudor domain found in Tudor domain-containing protein 5 (TDRD5) and similar proteins; TDRD5 is ...
 382-431 4.85e-03

Tudor domain found in Tudor domain-containing protein 5 (TDRD5) and similar proteins; TDRD5 is an RNA-binding protein directly associated with piRNA precursors. It is required for retrotransposon silencing, chromatoid body assembly, and spermiogenesis. TDRD5 participates in the repression of transposable elements and prevents their mobilization, which is essential for germline integrity. TDRD5 contains three LOTUS domains and one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410490  Cd Length: 118  Bit Score: 38.20  E-value: 4.85e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 2462537572  382 KVQIKGLPGHQEVEVKYVDFGNTAKITIKDVRKIKDEFLNAPEKAIKCKL 431
Cdd:cd20419     69 RVIIHQVLNKQEVEVFYPDFGDIGTVQKSRLRFLKCCYSKLPAQAIPASL 118
Tudor_TDRD5 cd20419
Tudor domain found in Tudor domain-containing protein 5 (TDRD5) and similar proteins; TDRD5 is ...
 559-668 8.90e-03

Tudor domain found in Tudor domain-containing protein 5 (TDRD5) and similar proteins; TDRD5 is an RNA-binding protein directly associated with piRNA precursors. It is required for retrotransposon silencing, chromatoid body assembly, and spermiogenesis. TDRD5 participates in the repression of transposable elements and prevents their mobilization, which is essential for germline integrity. TDRD5 contains three LOTUS domains and one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410490  Cd Length: 118  Bit Score: 37.43  E-value: 8.90e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462537572  559 HICNVISPEKIYVQwLLTENLLNSLEEKMIA-----AYENSKWEPVKWENDMH----CAVKIQDKNQWRRGQIIRMVTDT 629
Cdd:cd20419      1 FVEYIESPSQFYVR-FYSKDTSEMLEDMMIEmrrcySNEHVSERYVMPEAFIQpgqvCCVRIPEDVWWYRVIIHQVLNKQ 79

                           90       100       110
                   ....*....|....*....|....*....|....*....
gi 2462537572  630 LVEVLLYDVGVELVVNVDCLRKLEENLKTMGRLSLECSL 668
Cdd:cd20419     80 EVEVFYPDFGDIGTVQKSRLRFLKCCYSKLPAQAIPASL 118
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH