|
Name |
Accession |
Description |
Interval |
E-value |
| rfc |
PRK00440 |
replication factor C small subunit; Reviewed |
3-207 |
6.69e-45 |
|
replication factor C small subunit; Reviewed
Pssm-ID: 234763 [Multi-domain] Cd Length: 319 Bit Score: 155.03 E-value: 6.69e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462537589 3 LWVDKYRPCSLGRLDYHKEQAAQLRNLVQCGDFPHLLVYGPSGAGKKTRIMCILRELYGvgvEKLRiehqtittpskkki 82
Cdd:PRK00440 6 IWVEKYRPRTLDEIVGQEEIVERLKSYVKEKNMPHLLFAGPPGTGKTTAALALARELYG---EDWR-------------- 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462537589 83 eistiasNYHLEVNPSDAGNSDrvVIQEMLKTVAQSQQLETnsqRDFKVVLLTEVDKLTKDAQHALRRTMEKYMSTCRLI 162
Cdd:PRK00440 69 -------ENFLELNASDERGID--VIRNKIKEFARTAPVGG---APFKIIFLDEADNLTSDAQQALRRTMEMYSQNTRFI 136
|
170 180 190 200
....*....|....*....|....*....|....*....|....*
gi 2462537589 163 LCCNSTSKVIPPIRSRCLAVRVPAPSIEDICHVLSTVCKKEGLNL 207
Cdd:PRK00440 137 LSCNYSSKIIDPIQSRCAVFRFSPLKKEAVAERLRYIAENEGIEI 181
|
|
| HolB |
COG0470 |
DNA polymerase III, delta prime subunit [Replication, recombination and repair]; |
19-294 |
2.22e-32 |
|
DNA polymerase III, delta prime subunit [Replication, recombination and repair];
Pssm-ID: 440238 [Multi-domain] Cd Length: 289 Bit Score: 121.24 E-value: 2.22e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462537589 19 HKEQAAQLRNLVQCGDFPH-LLVYGPSGAGKKTRIMCILRELYGvgveklrieHQTITTPSKKKIEISTIASNYH---LE 94
Cdd:COG0470 1 QEEAWEQLLAAAESGRLPHaLLLHGPPGIGKTTLALALARDLLC---------ENPEGGKACGQCHSRLMAAGNHpdlLE 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462537589 95 VNPSDAGNSDRV-VIQEMLKTVAQSqqletnSQRD-FKVVLLTEVDKLTKDAQHALRRTMEKYMSTCRLILCCNSTSKVI 172
Cdd:COG0470 72 LNPEEKSDQIGIdQIRELGEFLSLT------PLEGgRKVVIIDEADAMNEAAANALLKTLEEPPKNTPFILIANDPSRLL 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462537589 173 PPIRSRCLAVRVPAPSIEDICHVLstvcKKEGlnLPSQLAHRLAEKSCRNLRKALLMCEAcrvqqypFTADQEIPETDWE 252
Cdd:COG0470 146 PTIRSRCQVIRFRPPSEEEALAWL----REEG--VDEDALEAILRLAGGDPRAAINLLQA-------LAGRKELLEDLAA 212
|
250 260 270 280
....*....|....*....|....*....|....*....|....*.
gi 2462537589 253 VYLR----ETANAIVSQQTPQRLLEVRGRLYELLTHCIPPEIIMKL 294
Cdd:COG0470 213 LLSRdralELLDALLKAEALELLDWLLKWLLDNLPLEYAGEDLARA 258
|
|
| AAA |
cd00009 |
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily ... |
21-179 |
8.20e-10 |
|
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, RecA-like, VirD4-like, PilT-like, and SF1/2 helicases. Members of the AAA+ ATPases function as molecular chaperons, ATPase subunits of proteases, helicases, or nucleic-acid stimulated ATPases. The AAA+ proteins contain several distinct features in addition to the conserved alpha-beta-alpha core domain structure and the Walker A and B motifs of the P-loop NTPases.
Pssm-ID: 99707 [Multi-domain] Cd Length: 151 Bit Score: 56.39 E-value: 8.20e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462537589 21 EQAAQLRNLVQCGDFPHLLVYGPSGAGKKTRIMCILRELYGVGVEklriehqtittpskkkieistiasnyHLEVNPSDA 100
Cdd:cd00009 5 EAIEALREALELPPPKNLLLYGPPGTGKTTLARAIANELFRPGAP--------------------------FLYLNASDL 58
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462537589 101 GNSDRVVIQEmlKTVAQSQQLETNSQRDFKVVLLTEVDKLTKDAQHALRRTMEKYMST------CRLILCCNSTS--KVI 172
Cdd:cd00009 59 LEGLVVAELF--GHFLVRLLFELAEKAKPGVLFIDEIDSLSRGAQNALLRVLETLNDLridrenVRVIGATNRPLlgDLD 136
|
....*..
gi 2462537589 173 PPIRSRC 179
Cdd:cd00009 137 RALYDRL 143
|
|
| DNA_pol3_delta2 |
pfam13177 |
DNA polymerase III, delta subunit; DNA polymerase III, delta subunit (EC 2.7.7.7) is required ... |
18-188 |
5.85e-07 |
|
DNA polymerase III, delta subunit; DNA polymerase III, delta subunit (EC 2.7.7.7) is required for, along with delta' subunit, the assembly of the processivity factor beta(2) onto primed DNA in the DNA polymerase III holoenzyme-catalyzed reaction. The delta subunit is also known as HolA.
Pssm-ID: 433013 [Multi-domain] Cd Length: 161 Bit Score: 48.36 E-value: 5.85e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462537589 18 YHKEQAAQLRNLVQCGDFPH-LLVYGPSGAGKKTRIMCILRELYGvgvEKLRIEHQTITTPSKKKIEistiaSNYHLEVN 96
Cdd:pfam13177 1 GQPEAIQLLQNSLENGRLSHaYLFSGPEGVGKLELALAFAKALFC---EEPGDDLPCGQCRSCRRIE-----SGNHPDLV 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462537589 97 P-SDAGNSDRV-VIQEMLKTVAQSQqLETNsqrdFKVVLLTEVDKLTKDAQHALRRTMEKYMSTCRLILCCNSTSKVIPP 174
Cdd:pfam13177 73 IiEPEGQSIKIdQIRELQKEFSKSP-YEGK----KKVYIIEDAEKMTASAANSLLKFLEEPPGNTVIILLTENPSRLLPT 147
|
170
....*....|....
gi 2462537589 175 IRSRCLAVRVPAPS 188
Cdd:pfam13177 148 IRSRCQIIRFKPLS 161
|
|
| AAA |
smart00382 |
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ... |
37-190 |
3.90e-06 |
|
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.
Pssm-ID: 214640 [Multi-domain] Cd Length: 148 Bit Score: 45.83 E-value: 3.90e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462537589 37 HLLVYGPSGAGKKTRIMCILRELYGVGVEKLRIEHQTITTPSKKKIeistiasnyHLEVNPSDAGNSDRVVIQEMLKTVA 116
Cdd:smart00382 4 VILIVGPPGSGKTTLARALARELGPPGGGVIYIDGEDILEEVLDQL---------LLIIVGGKKASGSGELRLRLALALA 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462537589 117 QsqqletnsQRDFKVVLLTEVDKLTKDAQHALRR--------TMEKYMSTCRLILCCNSTSKVIPPIRSRCLAVRVPAPS 188
Cdd:smart00382 75 R--------KLKPDVLILDEITSLLDAEQEALLLlleelrllLLLKSEKNLTVILTTNDEKDLGPALLRRRFDRRIVLLL 146
|
..
gi 2462537589 189 IE 190
Cdd:smart00382 147 IL 148
|
|
| HLD_clamp_RFC |
cd18140 |
helical lid domain of replication factor C subunit; Replication factor C (RFC) is five-protein ... |
187-252 |
2.10e-04 |
|
helical lid domain of replication factor C subunit; Replication factor C (RFC) is five-protein clamp loader complex that forms a stable ATP-dependent complex with the sliding clamp, PCNA, which binds specifically to primed DNA. RFC subunits belong to the clamp loader clade of the AAA+ superfamily.
Pssm-ID: 350842 [Multi-domain] Cd Length: 63 Bit Score: 38.66 E-value: 2.10e-04
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462537589 187 PSIEDICHVLSTVCKKEGLNLPSQLAHRLAEKSCRNLRKALLMCEACRVQqypftaDQEIPETDWE 252
Cdd:cd18140 1 LSKEQIVKRLREICKKEGVKIDEEALEAIAEKSEGDMRKAINDLQAAAAG------GGVITEEDVY 60
|
|
| rad24 |
TIGR00602 |
checkpoint protein rad24; All proteins in this family for which functions are known are ... |
3-164 |
9.94e-04 |
|
checkpoint protein rad24; All proteins in this family for which functions are known are involved in DNA damage tolerance (likely cell cycle checkpoints).This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 129690 [Multi-domain] Cd Length: 637 Bit Score: 40.71 E-value: 9.94e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462537589 3 LWVDKYRPCSLGRLDYHKEQAAQLRNLVQCGDFPH-----LLVYGPSGAGKKTRIMCILRELygvgVEKLR--IEHQTIT 75
Cdd:TIGR00602 73 PWVEKYKPETQHELAVHKKKIEEVETWLKAQVLENapkriLLITGPSGCGKSTTIKILSKEL----GIQVQewSNPTLPD 148
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462537589 76 TPSKKKIEISTIASNYHLEVnpsdagnSDRVVIQEMLKTVAQS-QQLETNSQRDFKVVLLTEVDK---LTKDAQHALRRT 151
Cdd:TIGR00602 149 FQKNDHKVTLSLESCFSNFQ-------SQIEVFSEFLLRATNKlQMLGDDLMTDKKIILVEDLPNqfyRDTRALHEILRW 221
|
170
....*....|...
gi 2462537589 152 MEKYMSTCRLILC 164
Cdd:TIGR00602 222 KYVSIGRCPLVFI 234
|
|
|
|
Name |
Accession |
Description |
Interval |
E-value |
| rfc |
PRK00440 |
replication factor C small subunit; Reviewed |
3-207 |
6.69e-45 |
|
replication factor C small subunit; Reviewed
Pssm-ID: 234763 [Multi-domain] Cd Length: 319 Bit Score: 155.03 E-value: 6.69e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462537589 3 LWVDKYRPCSLGRLDYHKEQAAQLRNLVQCGDFPHLLVYGPSGAGKKTRIMCILRELYGvgvEKLRiehqtittpskkki 82
Cdd:PRK00440 6 IWVEKYRPRTLDEIVGQEEIVERLKSYVKEKNMPHLLFAGPPGTGKTTAALALARELYG---EDWR-------------- 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462537589 83 eistiasNYHLEVNPSDAGNSDrvVIQEMLKTVAQSQQLETnsqRDFKVVLLTEVDKLTKDAQHALRRTMEKYMSTCRLI 162
Cdd:PRK00440 69 -------ENFLELNASDERGID--VIRNKIKEFARTAPVGG---APFKIIFLDEADNLTSDAQQALRRTMEMYSQNTRFI 136
|
170 180 190 200
....*....|....*....|....*....|....*....|....*
gi 2462537589 163 LCCNSTSKVIPPIRSRCLAVRVPAPSIEDICHVLSTVCKKEGLNL 207
Cdd:PRK00440 137 LSCNYSSKIIDPIQSRCAVFRFSPLKKEAVAERLRYIAENEGIEI 181
|
|
| PRK12402 |
PRK12402 |
replication factor C small subunit 2; Reviewed |
3-282 |
7.77e-45 |
|
replication factor C small subunit 2; Reviewed
Pssm-ID: 237090 [Multi-domain] Cd Length: 337 Bit Score: 155.53 E-value: 7.77e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462537589 3 LWVDKYRPCSLGRLDYHKEQAAQLRNLVQCGDFPHLLVYGPSGAGKKTRIMCILRELYGVGVEKLRIEHQTITTPSKKKI 82
Cdd:PRK12402 4 LWTEKYRPALLEDILGQDEVVERLSRAVDSPNLPHLLVQGPPGSGKTAAVRALARELYGDPWENNFTEFNVADFFDQGKK 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462537589 83 EISTIASNYHLEVNPSDAGNSDRVVIQEMLKTVAQSQQLETnsqrDFKVVLLTEVDKLTKDAQHALRRTMEKYMSTCRLI 162
Cdd:PRK12402 84 YLVEDPRFAHFLGTDKRIRSSKIDNFKHVLKEYASYRPLSA----DYKTILLDNAEALREDAQQALRRIMEQYSRTCRFI 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462537589 163 LCCNSTSKVIPPIRSRCLAVRVPAPSIEDICHVLSTVCKKEGLNLPSQLAHRLAEKSCRNLRKALLMCEACRVQQYPFTa 242
Cdd:PRK12402 160 IATRQPSKLIPPIRSRCLPLFFRAPTDDELVDVLESIAEAEGVDYDDDGLELIAYYAGGDLRKAILTLQTAALAAGEIT- 238
|
250 260 270 280
....*....|....*....|....*....|....*....|
gi 2462537589 243 DQEIPETDWEVYLRETANAIVSQQTPQRLLEVRGRLYELL 282
Cdd:PRK12402 239 MEAAYEALGDVGTDEVIESLLDAAEAGDFTDARKTLDDLL 278
|
|
| PLN03025 |
PLN03025 |
replication factor C subunit; Provisional |
4-205 |
6.22e-33 |
|
replication factor C subunit; Provisional
Pssm-ID: 178596 [Multi-domain] Cd Length: 319 Bit Score: 123.69 E-value: 6.22e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462537589 4 WVDKYRPCSLGRLDYHKEQAAQLRNLVQCGDFPHLLVYGPSGAGKKTRIMCILRELYGvgveklriehqtittPSKKkie 83
Cdd:PLN03025 3 WVEKYRPTKLDDIVGNEDAVSRLQVIARDGNMPNLILSGPPGTGKTTSILALAHELLG---------------PNYK--- 64
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462537589 84 istiasNYHLEVNPSDAGNSDrvVIQEMLKTVAQSQQleTNSQRDFKVVLLTEVDKLTKDAQHALRRTMEKYMSTCRLIL 163
Cdd:PLN03025 65 ------EAVLELNASDDRGID--VVRNKIKMFAQKKV--TLPPGRHKIVILDEADSMTSGAQQALRRTMEIYSNTTRFAL 134
|
170 180 190 200
....*....|....*....|....*....|....*....|..
gi 2462537589 164 CCNSTSKVIPPIRSRCLAVRVPAPSIEDICHVLSTVCKKEGL 205
Cdd:PLN03025 135 ACNTSSKIIEPIQSRCAIVRFSRLSDQEILGRLMKVVEAEKV 176
|
|
| HolB |
COG0470 |
DNA polymerase III, delta prime subunit [Replication, recombination and repair]; |
19-294 |
2.22e-32 |
|
DNA polymerase III, delta prime subunit [Replication, recombination and repair];
Pssm-ID: 440238 [Multi-domain] Cd Length: 289 Bit Score: 121.24 E-value: 2.22e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462537589 19 HKEQAAQLRNLVQCGDFPH-LLVYGPSGAGKKTRIMCILRELYGvgveklrieHQTITTPSKKKIEISTIASNYH---LE 94
Cdd:COG0470 1 QEEAWEQLLAAAESGRLPHaLLLHGPPGIGKTTLALALARDLLC---------ENPEGGKACGQCHSRLMAAGNHpdlLE 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462537589 95 VNPSDAGNSDRV-VIQEMLKTVAQSqqletnSQRD-FKVVLLTEVDKLTKDAQHALRRTMEKYMSTCRLILCCNSTSKVI 172
Cdd:COG0470 72 LNPEEKSDQIGIdQIRELGEFLSLT------PLEGgRKVVIIDEADAMNEAAANALLKTLEEPPKNTPFILIANDPSRLL 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462537589 173 PPIRSRCLAVRVPAPSIEDICHVLstvcKKEGlnLPSQLAHRLAEKSCRNLRKALLMCEAcrvqqypFTADQEIPETDWE 252
Cdd:COG0470 146 PTIRSRCQVIRFRPPSEEEALAWL----REEG--VDEDALEAILRLAGGDPRAAINLLQA-------LAGRKELLEDLAA 212
|
250 260 270 280
....*....|....*....|....*....|....*....|....*.
gi 2462537589 253 VYLR----ETANAIVSQQTPQRLLEVRGRLYELLTHCIPPEIIMKL 294
Cdd:COG0470 213 LLSRdralELLDALLKAEALELLDWLLKWLLDNLPLEYAGEDLARA 258
|
|
| PRK04132 |
PRK04132 |
replication factor C small subunit; Provisional |
93-282 |
1.06e-25 |
|
replication factor C small subunit; Provisional
Pssm-ID: 235223 [Multi-domain] Cd Length: 846 Bit Score: 107.23 E-value: 1.06e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462537589 93 LEVNPSDAGNSDrvVIQEMLKTVAQSQQLETNSqrdFKVVLLTEVDKLTKDAQHALRRTMEKYMSTCRLILCCNSTSKVI 172
Cdd:PRK04132 600 LELNASDERGIN--VIREKVKEFARTKPIGGAS---FKIIFLDEADALTQDAQQALRRTMEMFSSNVRFILSCNYSSKII 674
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462537589 173 PPIRSRCLAVRVPAPSIEDICHVLSTVCKKEGLNLPSQLAHRLAEKSCRNLRKALlmceacRVQQYPFTADQEIpeTDWE 252
Cdd:PRK04132 675 EPIQSRCAIFRFRPLRDEDIAKRLRYIAENEGLELTEEGLQAILYIAEGDMRRAI------NILQAAAALDDKI--TDEN 746
|
170 180 190 200
....*....|....*....|....*....|....*....|..
gi 2462537589 253 VYLretanaIVSQQTPQ------------RLLEVRGRLYELL 282
Cdd:PRK04132 747 VFL------VASRARPEdiremmllalkgNFLKAREKLREIL 782
|
|
| 44 |
PHA02544 |
clamp loader, small subunit; Provisional |
3-204 |
5.33e-18 |
|
clamp loader, small subunit; Provisional
Pssm-ID: 222866 [Multi-domain] Cd Length: 316 Bit Score: 82.73 E-value: 5.33e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462537589 3 LWVDKYRPCSLGRLDYHKEQAAQLRNLVQCGDFPHLLVYGPS-GAGKKTRIMCILRElygVGVEklriehqtittpskkk 81
Cdd:PHA02544 10 MWEQKYRPSTIDECILPAADKETFKSIVKKGRIPNMLLHSPSpGTGKTTVAKALCNE---VGAE---------------- 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462537589 82 ieistiasnyHLEVNPSDaGNSDrvVIQEMLKTVAQSQQLETNsqrdFKVVLLTEVDKL-TKDAQHALRRTMEKYMSTCR 160
Cdd:PHA02544 71 ----------VLFVNGSD-CRID--FVRNRLTRFASTVSLTGG----GKVIIIDEFDRLgLADAQRHLRSFMEAYSKNCS 133
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|.
gi 2462537589 161 LILCCNSTSKVIPPIRSRCLAVRVPAPSIED-------ICHVLSTVCKKEG 204
Cdd:PHA02544 134 FIITANNKNGIIEPLRSRCRVIDFGVPTKEEqiemmkqMIVRCKGILEAEG 184
|
|
| DnaX |
COG2812 |
DNA polymerase III, gamma/tau subunits [Replication, recombination and repair]; |
19-275 |
1.11e-13 |
|
DNA polymerase III, gamma/tau subunits [Replication, recombination and repair];
Pssm-ID: 442061 [Multi-domain] Cd Length: 340 Bit Score: 70.61 E-value: 1.11e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462537589 19 HKEQAAQLRNLVQCGDFPH-LLVYGPSGAGKKT--RIM-----CilrelygvgveklriEHQTITTP-----SKKKIeis 85
Cdd:COG2812 15 QEHVVRTLKNALASGRLAHaYLFTGPRGVGKTTlaRILakalnC---------------ENGPTGEPcgeceSCRAI--- 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462537589 86 tiASNYHLEVNPSDAGNSDRVV--IQEMLKTVAQSqqletNSQRDFKVVLLTEVDKLTKDAQHALRRTME------Kyms 157
Cdd:COG2812 77 --AAGSHPDVIEIDAEASNIGVddIRELIEKVSYA-----PVEGRYKVYIIDEAHMLTTEAFNALLKTLEeppphvV--- 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462537589 158 tcrLILCCNSTSKVIPPIRSRCLAVRVPAPSIEDICHVLSTVCKKEGLNLPSQLAHRLAEKSCRNLRKALLMceacrvqq 237
Cdd:COG2812 147 ---FILATTEPQKLLPTILSRCQRFDFRRLPPEEIAEHLAKIAEREGIEIEPEALALIARAADGSMRDALSL-------- 215
|
250 260 270 280
....*....|....*....|....*....|....*....|
gi 2462537589 238 ypftADQEIP--ETDWEVYLRETANAIVSQQTPQRLLEVR 275
Cdd:COG2812 216 ----LDQAIAfgLLDRRELLLDLLEALLAGDVAALLALAE 251
|
|
| PRK14962 |
PRK14962 |
DNA polymerase III subunits gamma and tau; Provisional |
7-231 |
5.77e-10 |
|
DNA polymerase III subunits gamma and tau; Provisional
Pssm-ID: 237869 [Multi-domain] Cd Length: 472 Bit Score: 59.78 E-value: 5.77e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462537589 7 KYRPCSLGRLDYHKEQAAQLRNLVQCGDFPHLLVY-GPSGAGKKT--RIMcilrelygvgVEKLRIEHQTITTPSKKKIE 83
Cdd:PRK14962 7 KYRPKTFSEVVGQDHVKKLIINALKKNSISHAYIFaGPRGTGKTTvaRIL----------AKSLNCENRKGVEPCNECRA 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462537589 84 ISTIASNYHLEVNPSDAGnSDRVV--IQEMLKTVAQsqqleTNSQRDFKVVLLTEVDKLTKDAQHALRRTMEKYMSTCRL 161
Cdd:PRK14962 77 CRSIDEGTFMDVIELDAA-SNRGIdeIRKIRDAVGY-----RPMEGKYKVYIIDEVHMLTKEAFNALLKTLEEPPSHVVF 150
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462537589 162 ILCCNSTSKVIPPIRSRCLAVRVPAPSIEDICHVLSTVCKKEGLNLPSQLAHRLAEKSCRNLRKALLMCE 231
Cdd:PRK14962 151 VLATTNLEKVPPTIISRCQVIEFRNISDELIIKRLQEVAEAEGIEIDREALSFIAKRASGGLRDALTMLE 220
|
|
| AAA |
cd00009 |
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily ... |
21-179 |
8.20e-10 |
|
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, RecA-like, VirD4-like, PilT-like, and SF1/2 helicases. Members of the AAA+ ATPases function as molecular chaperons, ATPase subunits of proteases, helicases, or nucleic-acid stimulated ATPases. The AAA+ proteins contain several distinct features in addition to the conserved alpha-beta-alpha core domain structure and the Walker A and B motifs of the P-loop NTPases.
Pssm-ID: 99707 [Multi-domain] Cd Length: 151 Bit Score: 56.39 E-value: 8.20e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462537589 21 EQAAQLRNLVQCGDFPHLLVYGPSGAGKKTRIMCILRELYGVGVEklriehqtittpskkkieistiasnyHLEVNPSDA 100
Cdd:cd00009 5 EAIEALREALELPPPKNLLLYGPPGTGKTTLARAIANELFRPGAP--------------------------FLYLNASDL 58
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462537589 101 GNSDRVVIQEmlKTVAQSQQLETNSQRDFKVVLLTEVDKLTKDAQHALRRTMEKYMST------CRLILCCNSTS--KVI 172
Cdd:cd00009 59 LEGLVVAELF--GHFLVRLLFELAEKAKPGVLFIDEIDSLSRGAQNALLRVLETLNDLridrenVRVIGATNRPLlgDLD 136
|
....*..
gi 2462537589 173 PPIRSRC 179
Cdd:cd00009 137 RALYDRL 143
|
|
| PRK14961 |
PRK14961 |
DNA polymerase III subunits gamma and tau; Provisional |
7-231 |
1.47e-09 |
|
DNA polymerase III subunits gamma and tau; Provisional
Pssm-ID: 184925 [Multi-domain] Cd Length: 363 Bit Score: 58.28 E-value: 1.47e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462537589 7 KYRPCSLGRLDYHKEQAAQLRNLVQCGDFPHL-LVYGPSGAGKKTrimcILRELygvgVEKLRIEHQTITTPSKKKIEIS 85
Cdd:PRK14961 9 KWRPQYFRDIIGQKHIVTAISNGLSLGRIHHAwLLSGTRGVGKTT----IARLL----AKSLNCQNGITSNPCRKCIICK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462537589 86 TIASNYHLEVNPSDAgnSDRVVIQEMLKTVAQSQQLETNSQrdFKVVLLTEVDKLTKDAQHALRRTMEKYMSTCRLILCC 165
Cdd:PRK14961 81 EIEKGLCLDLIEIDA--ASRTKVEEMREILDNIYYSPSKSR--FKVYLIDEVHMLSRHSFNALLKTLEEPPQHIKFILAT 156
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462537589 166 NSTSKVIPPIRSRCLAVRVPAPSIEDICHVLSTVCKKEGLNLPSQLAHRLAEKSCRNLRKALLMCE 231
Cdd:PRK14961 157 TDVEKIPKTILSRCLQFKLKIISEEKIFNFLKYILIKESIDTDEYALKLIAYHAHGSMRDALNLLE 222
|
|
| PRK14970 |
PRK14970 |
DNA polymerase III subunits gamma and tau; Provisional |
7-272 |
1.13e-08 |
|
DNA polymerase III subunits gamma and tau; Provisional
Pssm-ID: 184934 [Multi-domain] Cd Length: 367 Bit Score: 55.65 E-value: 1.13e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462537589 7 KYRPCSLGRLDYHKEQAAQLRNLVQCGDFPHLLVY-GPSGAGKKTrimCIlrelygvgveklRIEHQTITTPSkkkieIS 85
Cdd:PRK14970 10 KYRPQTFDDVVGQSHITNTLLNAIENNHLAQALLFcGPRGVGKTT---CA------------RILARKINQPG-----YD 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462537589 86 TIASNYHLEVNPSDAGNSDRVV-IQEMLKTVAQSQQLEtnsqrDFKVVLLTEVDKLTKDAQHALRRTMEKYMSTCRLILC 164
Cdd:PRK14970 70 DPNEDFSFNIFELDAASNNSVDdIRNLIDQVRIPPQTG-----KYKIYIIDEVHMLSSAAFNAFLKTLEEPPAHAIFILA 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462537589 165 CNSTSKVIPPIRSRCLAVRVPAPSIEDICHVLSTVCKKEGLNLPSQLAHRLAEKSCRNLRKALLMCEacRVQQYPFT--- 241
Cdd:PRK14970 145 TTEKHKIIPTILSRCQIFDFKRITIKDIKEHLAGIAVKEGIKFEDDALHIIAQKADGALRDALSIFD--RVVTFCGKnit 222
|
250 260 270
....*....|....*....|....*....|....
gi 2462537589 242 ---ADQEIPETDWEVYLRETaNAIVSQQTPQRLL 272
Cdd:PRK14970 223 rqaVTENLNILDYDTYINVT-DLILENKIPELLL 255
|
|
| PRK07940 |
PRK07940 |
DNA polymerase III subunit delta'; Validated |
108-216 |
1.21e-08 |
|
DNA polymerase III subunit delta'; Validated
Pssm-ID: 236134 [Multi-domain] Cd Length: 394 Bit Score: 55.69 E-value: 1.21e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462537589 108 IQEMLKTVAQSQQLETNSQrdFKVVLLTEVDKLTKDAQHALRRTMEKYMSTCRLILCCNSTSKVIPPIRSRCLAVRVPAP 187
Cdd:PRK07940 99 VDEVRELVTIAARRPSTGR--WRIVVIEDADRLTERAANALLKAVEEPPPRTVWLLCAPSPEDVLPTIRSRCRHVALRTP 176
|
90 100
....*....|....*....|....*....
gi 2462537589 188 SIEDICHVLStvckkEGLNLPSQLAHRLA 216
Cdd:PRK07940 177 SVEAVAEVLV-----RRDGVDPETARRAA 200
|
|
| PRK14957 |
PRK14957 |
DNA polymerase III subunits gamma and tau; Provisional |
7-227 |
2.70e-07 |
|
DNA polymerase III subunits gamma and tau; Provisional
Pssm-ID: 184921 [Multi-domain] Cd Length: 546 Bit Score: 51.62 E-value: 2.70e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462537589 7 KYRPCSLGRLDYHKEQAAQLRNLVQCGDFPHLLVY-GPSGAGKKT--RIMC-ILRELYGVGVEklriehqtittPSKKKI 82
Cdd:PRK14957 9 KYRPQSFAEVAGQQHALNSLVHALETQKVHHAYLFtGTRGVGKTTlgRLLAkCLNCKTGVTAE-----------PCNKCE 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462537589 83 EISTIASNYHLEVNPSDAgnSDRVVIQEMLKTVAQSQQLEtnSQRDFKVVLLTEVDKLTKDAQHALRRTMEKYMSTCRLI 162
Cdd:PRK14957 78 NCVAINNNSFIDLIEIDA--ASRTGVEETKEILDNIQYMP--SQGRYKVYLIDEVHMLSKQSFNALLKTLEEPPEYVKFI 153
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2462537589 163 LCCNSTSKVIPPIRSRCLAVRVPAPSIEDICHVLSTVCKKEGLNLPSQLAHRLAEKSCRNLRKAL 227
Cdd:PRK14957 154 LATTDYHKIPVTILSRCIQLHLKHISQADIKDQLKIILAKENINSDEQSLEYIAYHAKGSLRDAL 218
|
|
| PRK14953 |
PRK14953 |
DNA polymerase III subunits gamma and tau; Provisional |
129-227 |
2.97e-07 |
|
DNA polymerase III subunits gamma and tau; Provisional
Pssm-ID: 237867 [Multi-domain] Cd Length: 486 Bit Score: 51.75 E-value: 2.97e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462537589 129 FKVVLLTEVDKLTKDAQHALRRTMEKYMSTCRLILCCNSTSKVIPPIRSRCLAVRVPAPSIEDICHVLSTVCKKEGLNLP 208
Cdd:PRK14953 120 YKVYIIDEAHMLTKEAFNALLKTLEEPPPRTIFILCTTEYDKIPPTILSRCQRFIFSKPTKEQIKEYLKRICNEEKIEYE 199
|
90
....*....|....*....
gi 2462537589 209 SQLAHRLAEKSCRNLRKAL 227
Cdd:PRK14953 200 EKALDLLAQASEGGMRDAA 218
|
|
| PRK14971 |
PRK14971 |
DNA polymerase III subunit gamma/tau; |
129-272 |
4.00e-07 |
|
DNA polymerase III subunit gamma/tau;
Pssm-ID: 237874 [Multi-domain] Cd Length: 614 Bit Score: 51.31 E-value: 4.00e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462537589 129 FKVVLLTEVDKLTKDAQHALRRTMEKYMSTCRLILCCNSTSKVIPPIRSRCLAVRVPAPSIEDICHVLSTVCKKEGLNLP 208
Cdd:PRK14971 122 YKIYIIDEVHMLSQAAFNAFLKTLEEPPSYAIFILATTEKHKILPTILSRCQIFDFNRIQVADIVNHLQYVASKEGITAE 201
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462537589 209 SQLAHRLAEKSCRNLRKALLMCEacrvQQYPFTAD----QEIPET----DWEVYLRETaNAIVSQQTPQRLL 272
Cdd:PRK14971 202 PEALNVIAQKADGGMRDALSIFD----QVVSFTGGnityKSVIENlnilDYDYYFRLT-DALLAGKVSDSLL 268
|
|
| DNA_pol3_delta2 |
pfam13177 |
DNA polymerase III, delta subunit; DNA polymerase III, delta subunit (EC 2.7.7.7) is required ... |
18-188 |
5.85e-07 |
|
DNA polymerase III, delta subunit; DNA polymerase III, delta subunit (EC 2.7.7.7) is required for, along with delta' subunit, the assembly of the processivity factor beta(2) onto primed DNA in the DNA polymerase III holoenzyme-catalyzed reaction. The delta subunit is also known as HolA.
Pssm-ID: 433013 [Multi-domain] Cd Length: 161 Bit Score: 48.36 E-value: 5.85e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462537589 18 YHKEQAAQLRNLVQCGDFPH-LLVYGPSGAGKKTRIMCILRELYGvgvEKLRIEHQTITTPSKKKIEistiaSNYHLEVN 96
Cdd:pfam13177 1 GQPEAIQLLQNSLENGRLSHaYLFSGPEGVGKLELALAFAKALFC---EEPGDDLPCGQCRSCRRIE-----SGNHPDLV 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462537589 97 P-SDAGNSDRV-VIQEMLKTVAQSQqLETNsqrdFKVVLLTEVDKLTKDAQHALRRTMEKYMSTCRLILCCNSTSKVIPP 174
Cdd:pfam13177 73 IiEPEGQSIKIdQIRELQKEFSKSP-YEGK----KKVYIIEDAEKMTASAANSLLKFLEEPPGNTVIILLTENPSRLLPT 147
|
170
....*....|....
gi 2462537589 175 IRSRCLAVRVPAPS 188
Cdd:pfam13177 148 IRSRCQIIRFKPLS 161
|
|
| AAA |
smart00382 |
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ... |
37-190 |
3.90e-06 |
|
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.
Pssm-ID: 214640 [Multi-domain] Cd Length: 148 Bit Score: 45.83 E-value: 3.90e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462537589 37 HLLVYGPSGAGKKTRIMCILRELYGVGVEKLRIEHQTITTPSKKKIeistiasnyHLEVNPSDAGNSDRVVIQEMLKTVA 116
Cdd:smart00382 4 VILIVGPPGSGKTTLARALARELGPPGGGVIYIDGEDILEEVLDQL---------LLIIVGGKKASGSGELRLRLALALA 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462537589 117 QsqqletnsQRDFKVVLLTEVDKLTKDAQHALRR--------TMEKYMSTCRLILCCNSTSKVIPPIRSRCLAVRVPAPS 188
Cdd:smart00382 75 R--------KLKPDVLILDEITSLLDAEQEALLLlleelrllLLLKSEKNLTVILTTNDEKDLGPALLRRRFDRRIVLLL 146
|
..
gi 2462537589 189 IE 190
Cdd:smart00382 147 IL 148
|
|
| PRK14956 |
PRK14956 |
DNA polymerase III subunits gamma and tau; Provisional |
7-231 |
4.19e-06 |
|
DNA polymerase III subunits gamma and tau; Provisional
Pssm-ID: 184920 [Multi-domain] Cd Length: 484 Bit Score: 48.02 E-value: 4.19e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462537589 7 KYRPCSLGRLDYHKEQAAQLRNLVQCGDFPHLLVY-GPSGAGKKTrimcILRELygvgVEKLRIEHQTITTPSKKK---I 82
Cdd:PRK14956 11 KYRPQFFRDVIHQDLAIGALQNALKSGKIGHAYIFfGPRGVGKTT----IARIL----AKRLNCENPIGNEPCNECtscL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462537589 83 EISTIASNYHLEVNPsdAGNSDRVVIQEMLKTVAQSQQletnsQRDFKVVLLTEVDKLTKDAQHALRRTMEKYMSTCRLI 162
Cdd:PRK14956 83 EITKGISSDVLEIDA--ASNRGIENIRELRDNVKFAPM-----GGKYKVYIIDEVHMLTDQSFNALLKTLEEPPAHIVFI 155
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462537589 163 LCCNSTSKVIPPIRSRC---LAVRVPAPSIEDichVLSTVCKKEGLNLPSQLAHRLAEKSCRNLRKALLMCE 231
Cdd:PRK14956 156 LATTEFHKIPETILSRCqdfIFKKVPLSVLQD---YSEKLCKIENVQYDQEGLFWIAKKGDGSVRDMLSFME 224
|
|
| PRK14960 |
PRK14960 |
DNA polymerase III subunit gamma/tau; |
7-227 |
5.81e-06 |
|
DNA polymerase III subunit gamma/tau;
Pssm-ID: 237868 [Multi-domain] Cd Length: 702 Bit Score: 47.73 E-value: 5.81e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462537589 7 KYRPCSLGRLDYHKEQAAQLRNLVQCGDFPHLLVY-GPSGAGKKTrimcILRELygvgVEKLRIEHQTITTPSKKKIEIS 85
Cdd:PRK14960 8 KYRPRNFNELVGQNHVSRALSSALERGRLHHAYLFtGTRGVGKTT----IARIL----AKCLNCETGVTSTPCEVCATCK 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462537589 86 TIASNYHLEVNPSDAGNSDRVV-IQEMLKTVAQSQqletnSQRDFKVVLLTEVDKLTKDAQHALRRTMEKYMSTCRLILC 164
Cdd:PRK14960 80 AVNEGRFIDLIEIDAASRTKVEdTRELLDNVPYAP-----TQGRFKVYLIDEVHMLSTHSFNALLKTLEEPPEHVKFLFA 154
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462537589 165 CNSTSKVIPPIRSRCLAVRVPAPSIEDICHVLSTVCKKEGLNLPSQLAHRLAEKSCRNLRKAL 227
Cdd:PRK14960 155 TTDPQKLPITVISRCLQFTLRPLAVDEITKHLGAILEKEQIAADQDAIWQIAESAQGSLRDAL 217
|
|
| PRK05707 |
PRK05707 |
DNA polymerase III subunit delta'; Validated |
22-191 |
1.41e-05 |
|
DNA polymerase III subunit delta'; Validated
Pssm-ID: 180215 [Multi-domain] Cd Length: 328 Bit Score: 45.85 E-value: 1.41e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462537589 22 QAAQLRNLVQCGDFPH-LLVYGPSGAGKK---TRIMCIL-----RELYGVGveklriehqtittpSKKKIEISTIAS--- 89
Cdd:PRK05707 8 QQSLWQQLAGRGRHPHaYLLHGPAGIGKRalaERLAAALlceapQGGGACG--------------SCKGCQLLRAGShpd 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462537589 90 NYHLEvnPSDAGNSDRV-VIQEMLKTVAQSQQletnsQRDFKVVLLTEVDKLTKDAQHALRRTMEKYMSTCRLILCCNST 168
Cdd:PRK05707 74 NFVLE--PEEADKTIKVdQVRELVSFVVQTAQ-----LGGRKVVLIEPAEAMNRNAANALLKSLEEPSGDTVLLLISHQP 146
|
170 180
....*....|....*....|...
gi 2462537589 169 SKVIPPIRSRCLAVRVPAPSIED 191
Cdd:PRK05707 147 SRLLPTIKSRCQQQACPLPSNEE 169
|
|
| PRK05564 |
PRK05564 |
DNA polymerase III subunit delta'; Validated |
128-192 |
1.98e-05 |
|
DNA polymerase III subunit delta'; Validated
Pssm-ID: 180132 [Multi-domain] Cd Length: 313 Bit Score: 45.41 E-value: 1.98e-05
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2462537589 128 DFKVVLLTEVDKLTKDAQHALRRTMEKYMSTCRLILCCNSTSKVIPPIRSRCLAVRVPAPSIEDI 192
Cdd:PRK05564 93 DKKVIIIYNSEKMTEQAQNAFLKTIEEPPKGVFIILLCENLEQILDTIKSRCQIYKLNRLSKEEI 157
|
|
| PRK14964 |
PRK14964 |
DNA polymerase III subunits gamma and tau; Provisional |
7-231 |
2.38e-05 |
|
DNA polymerase III subunits gamma and tau; Provisional
Pssm-ID: 237870 [Multi-domain] Cd Length: 491 Bit Score: 45.55 E-value: 2.38e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462537589 7 KYRPCSLGRLDYHKEQAAQLRNLVQCGDFPH-LLVYGPSGAGKKT--RI--MCilrelygvgvekLRIEHQTITTPSKKK 81
Cdd:PRK14964 6 KYRPSSFKDLVGQDVLVRILRNAFTLNKIPQsILLVGASGVGKTTcaRIisLC------------LNCSNGPTSDPCGTC 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462537589 82 IEISTIASNYHLEVNPSDAGNSDRV----VIQEmlktvaQSQQLETNSQrdFKVVLLTEVDKLTKDAQHALRRTMEKYMS 157
Cdd:PRK14964 74 HNCISIKNSNHPDVIEIDAASNTSVddikVILE------NSCYLPISSK--FKVYIIDEVHMLSNSAFNALLKTLEEPAP 145
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2462537589 158 TCRLILCCNSTSKVIPPIRSRCLAVRVPAPSIEDICHVLSTVCKKEGLNLPSQLAHRLAEKSCRNLRKALLMCE 231
Cdd:PRK14964 146 HVKFILATTEVKKIPVTIISRCQRFDLQKIPTDKLVEHLVDIAKKENIEHDEESLKLIAENSSGSMRNALFLLE 219
|
|
| PRK08691 |
PRK08691 |
DNA polymerase III subunits gamma and tau; Validated |
7-222 |
8.61e-05 |
|
DNA polymerase III subunits gamma and tau; Validated
Pssm-ID: 236333 [Multi-domain] Cd Length: 709 Bit Score: 43.93 E-value: 8.61e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462537589 7 KYRPCSLGRLDYHKEQAAQLRNLVQCGDFPH-LLVYGPSGAGKKTrimcILRELygvgVEKLRIEHQTITTPSKKKIEIS 85
Cdd:PRK08691 9 KWRPKTFADLVGQEHVVKALQNALDEGRLHHaYLLTGTRGVGKTT----IARIL----AKSLNCENAQHGEPCGVCQSCT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462537589 86 TIASNYHLEVNPSDAGNSDRVviqEMLKTVAQSQQLETNSQRdFKVVLLTEVDKLTKDAQHALRRTMEKYMSTCRLILCC 165
Cdd:PRK08691 81 QIDAGRYVDLLEIDAASNTGI---DNIREVLENAQYAPTAGK-YKVYIIDEVHMLSKSAFNAMLKTLEEPPEHVKFILAT 156
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462537589 166 NSTSKVIPPIRSRCLAVRVPAPSIEDICHVLSTVCKKEGLNLPS---QLAHRLAEKSCRN 222
Cdd:PRK08691 157 TDPHKVPVTVLSRCLQFVLRNMTAQQVADHLAHVLDSEKIAYEPpalQLLGRAAAGSMRD 216
|
|
| PRK14963 |
PRK14963 |
DNA polymerase III subunits gamma and tau; Provisional |
130-222 |
1.17e-04 |
|
DNA polymerase III subunits gamma and tau; Provisional
Pssm-ID: 184927 [Multi-domain] Cd Length: 504 Bit Score: 43.68 E-value: 1.17e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462537589 130 KVVLLTEVDKLTKDAQHALRRTMEKYMSTCRLILCCNSTSKVIPPIRSRCLAVRVPAPSIEDICHVLSTVCKKEGLNLPS 209
Cdd:PRK14963 118 KVYILDEAHMMSKSAFNALLKTLEEPPEHVIFILATTEPEKMPPTILSRTQHFRFRRLTEEEIAGKLRRLLEAEGREAEP 197
|
90
....*....|....*.
gi 2462537589 210 ---QLAHRLAEKSCRN 222
Cdd:PRK14963 198 ealQLVARLADGAMRD 213
|
|
| PRK04132 |
PRK04132 |
replication factor C small subunit; Provisional |
4-48 |
1.20e-04 |
|
replication factor C small subunit; Provisional
Pssm-ID: 235223 [Multi-domain] Cd Length: 846 Bit Score: 43.67 E-value: 1.20e-04
10 20 30 40
....*....|....*....|....*....|....*....|....*
gi 2462537589 4 WVDKYRPCSLGRLDYHKEQAAQLRNLVQCGDFPHLLVYGPSGAGK 48
Cdd:PRK04132 9 WVEKYRPQRLDDIVGQEHIVKRLKHYVKTGSMPHLLFAGPPGVGK 53
|
|
| PRK06305 |
PRK06305 |
DNA polymerase III subunits gamma and tau; Validated |
87-226 |
1.82e-04 |
|
DNA polymerase III subunits gamma and tau; Validated
Pssm-ID: 180523 [Multi-domain] Cd Length: 451 Bit Score: 42.84 E-value: 1.82e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462537589 87 IASNYHLEVNPSDaGNSDRVV--IQEMLKTVaqsqqLETNSQRDFKVVLLTEVDKLTKDAQHALRRTMEKYMSTCRLILC 164
Cdd:PRK06305 84 ISSGTSLDVLEID-GASHRGIedIRQINETV-----LFTPSKSRYKIYIIDEVHMLTKEAFNSLLKTLEEPPQHVKFFLA 157
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2462537589 165 CNSTSKVIPPIRSRC---LAVRVPAPSIEDichVLSTVCKKEGLNLPSQLAHRLAEKSCRNLRKA 226
Cdd:PRK06305 158 TTEIHKIPGTILSRCqkmHLKRIPEETIID---KLALIAKQEGIETSREALLPIARAAQGSLRDA 219
|
|
| HLD_clamp_RFC |
cd18140 |
helical lid domain of replication factor C subunit; Replication factor C (RFC) is five-protein ... |
187-252 |
2.10e-04 |
|
helical lid domain of replication factor C subunit; Replication factor C (RFC) is five-protein clamp loader complex that forms a stable ATP-dependent complex with the sliding clamp, PCNA, which binds specifically to primed DNA. RFC subunits belong to the clamp loader clade of the AAA+ superfamily.
Pssm-ID: 350842 [Multi-domain] Cd Length: 63 Bit Score: 38.66 E-value: 2.10e-04
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462537589 187 PSIEDICHVLSTVCKKEGLNLPSQLAHRLAEKSCRNLRKALLMCEACRVQqypftaDQEIPETDWE 252
Cdd:cd18140 1 LSKEQIVKRLREICKKEGVKIDEEALEAIAEKSEGDMRKAINDLQAAAAG------GGVITEEDVY 60
|
|
| PRK06645 |
PRK06645 |
DNA polymerase III subunits gamma and tau; Validated |
39-234 |
2.20e-04 |
|
DNA polymerase III subunits gamma and tau; Validated
Pssm-ID: 180643 [Multi-domain] Cd Length: 507 Bit Score: 42.54 E-value: 2.20e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462537589 39 LVYGPSGAGKKTRIMCILRelyGVGVEKLRIEHQTITTPSKKKIEIStIASNYHLEVNPSDAGNSDRVviqEMLKTVAQS 118
Cdd:PRK06645 47 LLTGIRGVGKTTSARIIAK---AVNCSALITENTTIKTCEQCTNCIS-FNNHNHPDIIEIDAASKTSV---DDIRRIIES 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462537589 119 QQLETnSQRDFKVVLLTEVDKLTKDAQHALRRTMEKYMSTCRLILCCNSTSKVIPPIRSRCLAVRVPAPSIEDICHVLST 198
Cdd:PRK06645 120 AEYKP-LQGKHKIFIIDEVHMLSKGAFNALLKTLEEPPPHIIFIFATTEVQKIPATIISRCQRYDLRRLSFEEIFKLLEY 198
|
170 180 190
....*....|....*....|....*....|....*.
gi 2462537589 199 VCKKEGLNLPSQLAHRLAEKSCRNLRKALLMCEACR 234
Cdd:PRK06645 199 ITKQENLKTDIEALRIIAYKSEGSARDAVSILDQAA 234
|
|
| PRK07132 |
PRK07132 |
DNA polymerase III subunit delta'; Validated |
121-192 |
2.52e-04 |
|
DNA polymerase III subunit delta'; Validated
Pssm-ID: 180855 [Multi-domain] Cd Length: 299 Bit Score: 42.02 E-value: 2.52e-04
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462537589 121 LETNSQRDFKVVLLTEVDKLTKDAQHALRRTMEKYMSTCRLILCCNSTSKVIPPIRSRCLAVRVPAPSIEDI 192
Cdd:PRK07132 83 FSSFVQSQKKILIIKNIEKTSNSLLNALLKTIEEPPKDTYFLLTTKNINKVLPTIVSRCQVFNVKEPDQQKI 154
|
|
| PRK14969 |
PRK14969 |
DNA polymerase III subunits gamma and tau; Provisional |
129-227 |
3.24e-04 |
|
DNA polymerase III subunits gamma and tau; Provisional
Pssm-ID: 237873 [Multi-domain] Cd Length: 527 Bit Score: 42.04 E-value: 3.24e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462537589 129 FKVVLLTEVDKLTKDAQHALRRTMEKYMSTCRLILCCNSTSKVIPPIRSRCLAV---RVPAPSI-EDICHVLStvckKEG 204
Cdd:PRK14969 120 FKVYIIDEVHMLSKSAFNAMLKTLEEPPEHVKFILATTDPQKIPVTVLSRCLQFnlkQMPPPLIvSHLQHILE----QEN 195
|
90 100
....*....|....*....|...
gi 2462537589 205 LNLPSQLAHRLAEKSCRNLRKAL 227
Cdd:PRK14969 196 IPFDATALQLLARAAAGSMRDAL 218
|
|
| PRK09112 |
PRK09112 |
DNA polymerase III subunit delta'; Validated |
123-229 |
6.92e-04 |
|
DNA polymerase III subunit delta'; Validated
Pssm-ID: 169667 [Multi-domain] Cd Length: 351 Bit Score: 40.79 E-value: 6.92e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462537589 123 TNSQRDFKVVLLTEVDKLTKDAQHALRRTMEKYMSTCRLILCCNSTSKVIPPIRSRCLAVRVPAPSIEDICHVLSTVckk 202
Cdd:PRK09112 136 TSGDGNWRIVIIDPADDMNRNAANAILKTLEEPPARALFILISHSSGRLLPTIRSRCQPISLKPLDDDELKKALSHL--- 212
|
90 100
....*....|....*....|....*....
gi 2462537589 203 eGLNLPSQLAHR--LAEKSCRNLRKALLM 229
Cdd:PRK09112 213 -GSSQGSDGEITeaLLQRSKGSVRKALLL 240
|
|
| rad24 |
TIGR00602 |
checkpoint protein rad24; All proteins in this family for which functions are known are ... |
3-164 |
9.94e-04 |
|
checkpoint protein rad24; All proteins in this family for which functions are known are involved in DNA damage tolerance (likely cell cycle checkpoints).This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 129690 [Multi-domain] Cd Length: 637 Bit Score: 40.71 E-value: 9.94e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462537589 3 LWVDKYRPCSLGRLDYHKEQAAQLRNLVQCGDFPH-----LLVYGPSGAGKKTRIMCILRELygvgVEKLR--IEHQTIT 75
Cdd:TIGR00602 73 PWVEKYKPETQHELAVHKKKIEEVETWLKAQVLENapkriLLITGPSGCGKSTTIKILSKEL----GIQVQewSNPTLPD 148
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462537589 76 TPSKKKIEISTIASNYHLEVnpsdagnSDRVVIQEMLKTVAQS-QQLETNSQRDFKVVLLTEVDK---LTKDAQHALRRT 151
Cdd:TIGR00602 149 FQKNDHKVTLSLESCFSNFQ-------SQIEVFSEFLLRATNKlQMLGDDLMTDKKIILVEDLPNqfyRDTRALHEILRW 221
|
170
....*....|...
gi 2462537589 152 MEKYMSTCRLILC 164
Cdd:TIGR00602 222 KYVSIGRCPLVFI 234
|
|
| Rad17 |
pfam03215 |
Rad17 P-loop domain; |
3-169 |
1.21e-03 |
|
Rad17 P-loop domain;
Pssm-ID: 367398 [Multi-domain] Cd Length: 186 Bit Score: 39.17 E-value: 1.21e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462537589 3 LWVDKYRPCSLGRLDYHKEQAAQLRNLVQCGDFPH-----LLVYGPSGAGKKTRIMCILRELygvgVEKLR--IEHQTIT 75
Cdd:pfam03215 8 QWYEKYKPNCLEQLAVHKRKIKDVQEWLDAMFLENakhriLLISGPSGCGKSTVIKELSKEL----GPKYRewSNPTSFR 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462537589 76 TPSKKKieistiaSNYHLEVNPSDAGNSDRVVIQEMLKTVAQS---QQLETNSQRDFKVVLLTEVDKLTKDAQHALRRTM 152
Cdd:pfam03215 84 SPPNQV-------TDFRGDCIVNSRFLSQMESFSEFELKGARYlvmQKRGKNAQGNKKLILIEDLPNVFHIDTRRFQQVI 156
|
170 180
....*....|....*....|...
gi 2462537589 153 EKYMSTCR---LILC---CNSTS 169
Cdd:pfam03215 157 RQWLYSSEplpLIICiteCEILE 179
|
|
| PRK14950 |
PRK14950 |
DNA polymerase III subunits gamma and tau; Provisional |
7-227 |
3.62e-03 |
|
DNA polymerase III subunits gamma and tau; Provisional
Pssm-ID: 237864 [Multi-domain] Cd Length: 585 Bit Score: 39.02 E-value: 3.62e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462537589 7 KYRPCSLGRLDYHKEQAAQLRNLVQCGDFPH-LLVYGPSGAGKKTrimcilrelygvgVEKLRIEHQTITTPSKKKIEIS 85
Cdd:PRK14950 9 KWRSQTFAELVGQEHVVQTLRNAIAEGRVAHaYLFTGPRGVGKTS-------------TARILAKAVNCTTNDPKGRPCG 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462537589 86 T------IASNYHLEVNPSDAGNSDRVV-IQEMLKTVAQSQqletnSQRDFKVVLLTEVDKLTKDAQHALRRTMEKYMST 158
Cdd:PRK14950 76 TcemcraIAEGSAVDVIEMDAASHTSVDdAREIIERVQFRP-----ALARYKVYIIDEVHMLSTAAFNALLKTLEEPPPH 150
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2462537589 159 CRLILCCNSTSKVIPPIRSRCLAVRVPAPSIEDICHVLSTVCKKEGLNLPSQLAHRLAEKSCRNLRKAL 227
Cdd:PRK14950 151 AIFILATTEVHKVPATILSRCQRFDFHRHSVADMAAHLRKIAAAEGINLEPGALEAIARAATGSMRDAE 219
|
|
| AAA_22 |
pfam13401 |
AAA domain; |
37-164 |
7.69e-03 |
|
AAA domain;
Pssm-ID: 379165 [Multi-domain] Cd Length: 129 Bit Score: 36.17 E-value: 7.69e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462537589 37 HLLVYGPSGAGKKTRIMCILRELYGVGVEKLRIehqTITTPSKKKIEISTIASNYHLEVNpsdagnsDRVVIQEMLKTVA 116
Cdd:pfam13401 7 ILVLTGESGTGKTTLLRRLLEQLPEVRDSVVFV---DLPSGTSPKDLLRALLRALGLPLS-------GRLSKEELLAALQ 76
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 2462537589 117 qsQQLetNSQRDFKVVLLTEVDKLTKDAQHALRRTMEKYMSTCRLILC 164
Cdd:pfam13401 77 --QLL--LALAVAVVLIIDEAQHLSLEALEELRDLLNLSSKLLQLILV 120
|
|
|