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Conserved domains on  [gi|2462537971|ref|XP_054230942|]
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N-alpha-acetyltransferase 16, NatA auxiliary subunit isoform X7 [Homo sapiens]

Protein Classification

TPR and NARP1 domain-containing protein( domain architecture ID 11420148)

TPR and NARP1 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NatA_aux_su super family cl26342
N-terminal acetyltransferase A, auxiliary subunit; This entry represents N-terminal ...
 187-338 8.77e-66

N-terminal acetyltransferase A, auxiliary subunit; This entry represents N-terminal acetyltransferase A (NatA) auxiliary subunit (also known as NMDA receptor-regulated protein 1), which is a non-catalytic component of the NatA N-terminal acetyltransferase that catalyzes acetylation of proteins beginning with Met-Ser, Met-Gly and Met-Ala. N-terminal acetylation plays a role in normal eukaryotic translation and processing, protecting against proteolytic degradation and protein turnover. NAT1 anchors ARD1 and NAT5 to the ribosome, and may present the N terminus of nascent polypeptides for acetylation.


The actual alignment was detected with superfamily member pfam12569:

Pssm-ID: 463630 [Multi-domain]  Cd Length: 514  Bit Score: 215.60  E-value: 8.77e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462537971 187 YEYSELILYQNQVMREADLLQESLEHIEMYEKQICDKLLVEEIKGEILLKLGRLKEASEVFKNLIDRNAENWCYYEGLEK 266
Cdd:pfam12569   1 YEHSELLLYKNQIIAESGDLEEALEHLEKVEKQIVDKLAVLETKADYLLKLGRKEEAEATYRALLERNPENHAYYEGLEK 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2462537971 267 ALQIST--LEERLQIYEEISKQHPKAITPRRLPLTLVPGERFRELMDKFLRVNFSKGCPPLFTTLKSLYYNTEK 338
Cdd:pfam12569  81 ALGISKedHEALLALYDELAEKYPRSDAPRRLPLDFLEGEEFKELADKYLRRMLRKGVPSLFVNLKSLYTDSEK 154
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
21-243 7.09e-15

Tetratricopeptide (TPR) repeat [General function prediction only];


:

Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 73.12  E-value: 7.09e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462537971  21 YEQKQYKNGLKFCKMILS-NPKFAEhgeTLAMKGLTLNCLGKKEEAYEFVRKGLRNDVKSHVCWHVYGLLQRSDKKYDEA 99
Cdd:COG0457    19 RRLGRYEEAIEDYEKALElDPDDAE---ALYNLGLAYLRLGRYEEALADYEQALELDPDDAEALNNLGLALQALGRYEEA 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462537971 100 IKCYRNALKLDKDNLQILRDLSLLQIQMRDLEGYRETRYQLLQLRPTQRASWIGYAIAYHLLKDYDMALKLLEEFRQTQQ 179
Cdd:COG0457    96 LEDYDKALELDPDDAEALYNLGLALLELGRYDEAIEAYERALELDPDDADALYNLGIALEKLGRYEEALELLEKLEAAAL 175

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2462537971 180 VPPNKIDYEYSELILYQNQVMREADLLQESLEHIEMYEKQICDKLLVEEIKGEILLKLGRLKEA 243
Cdd:COG0457   176 AALLAAALGEAALALAAAEVLLALLLALEQALRKKLAILTLAALAELLLLALALLLALRLAALA 239
 
Name Accession Description Interval E-value
NatA_aux_su pfam12569
N-terminal acetyltransferase A, auxiliary subunit; This entry represents N-terminal ...
 187-338 8.77e-66

N-terminal acetyltransferase A, auxiliary subunit; This entry represents N-terminal acetyltransferase A (NatA) auxiliary subunit (also known as NMDA receptor-regulated protein 1), which is a non-catalytic component of the NatA N-terminal acetyltransferase that catalyzes acetylation of proteins beginning with Met-Ser, Met-Gly and Met-Ala. N-terminal acetylation plays a role in normal eukaryotic translation and processing, protecting against proteolytic degradation and protein turnover. NAT1 anchors ARD1 and NAT5 to the ribosome, and may present the N terminus of nascent polypeptides for acetylation.


Pssm-ID: 463630 [Multi-domain]  Cd Length: 514  Bit Score: 215.60  E-value: 8.77e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462537971 187 YEYSELILYQNQVMREADLLQESLEHIEMYEKQICDKLLVEEIKGEILLKLGRLKEASEVFKNLIDRNAENWCYYEGLEK 266
Cdd:pfam12569   1 YEHSELLLYKNQIIAESGDLEEALEHLEKVEKQIVDKLAVLETKADYLLKLGRKEEAEATYRALLERNPENHAYYEGLEK 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2462537971 267 ALQIST--LEERLQIYEEISKQHPKAITPRRLPLTLVPGERFRELMDKFLRVNFSKGCPPLFTTLKSLYYNTEK 338
Cdd:pfam12569  81 ALGISKedHEALLALYDELAEKYPRSDAPRRLPLDFLEGEEFKELADKYLRRMLRKGVPSLFVNLKSLYTDSEK 154
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
21-243 7.09e-15

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 73.12  E-value: 7.09e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462537971  21 YEQKQYKNGLKFCKMILS-NPKFAEhgeTLAMKGLTLNCLGKKEEAYEFVRKGLRNDVKSHVCWHVYGLLQRSDKKYDEA 99
Cdd:COG0457    19 RRLGRYEEAIEDYEKALElDPDDAE---ALYNLGLAYLRLGRYEEALADYEQALELDPDDAEALNNLGLALQALGRYEEA 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462537971 100 IKCYRNALKLDKDNLQILRDLSLLQIQMRDLEGYRETRYQLLQLRPTQRASWIGYAIAYHLLKDYDMALKLLEEFRQTQQ 179
Cdd:COG0457    96 LEDYDKALELDPDDAEALYNLGLALLELGRYDEAIEAYERALELDPDDADALYNLGIALEKLGRYEEALELLEKLEAAAL 175

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2462537971 180 VPPNKIDYEYSELILYQNQVMREADLLQESLEHIEMYEKQICDKLLVEEIKGEILLKLGRLKEA 243
Cdd:COG0457   176 AALLAAALGEAALALAAAEVLLALLLALEQALRKKLAILTLAALAELLLLALALLLALRLAALA 239
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 83-291 1.17e-09

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 58.20  E-value: 1.17e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462537971  83 WHVYGLLQRSDKKYDEAIKCYRNALKLDKDNLQILRDLSLLQIQMRDLEGYRETRYQLLQLRPTQRASWIGYAIAYHLLK 162
Cdd:COG2956    11 WYFKGLNYLLNGQPDKAIDLLEEALELDPETVEAHLALGNLYRRRGEYDRAIRIHQKLLERDPDRAEALLELAQDYLKAG 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462537971 163 DYDMALKLLEEFRQTqqvPPNKIDYEYSELILYQnqvmREADlLQESLEHIEMYEKQICDKLLVEEIKGEILLKLGRLKE 242
Cdd:COG2956    91 LLDRAEELLEKLLEL---DPDDAEALRLLAEIYE----QEGD-WEKAIEVLERLLKLGPENAHAYCELAELYLEQGDYDE 162

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 2462537971 243 ASEVFKNLIDRNAENWCYYEGLEK-ALQISTLEERLQIYEEISKQHPKAI 291
Cdd:COG2956   163 AIEALEKALKLDPDCARALLLLAElYLEQGDYEEAIAALERALEQDPDYL 212
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 39-257 2.88e-07

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 52.01  E-value: 2.88e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462537971  39 NPKFAEHGETLAMKGLTLNclgKKEEAYEFVRKGLRNDVKSHVCWHVYGLLQRSDKKYDEAIKCYRNALKLDKDNLQILR 118
Cdd:TIGR02917 155 DPRSLYAKLGLAQLALAEN---RFDEARALIDEVLTADPGNVDALLLKGDLLLSLGNIELALAAYRKAIALRPNNIAVLL 231

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462537971 119 DLSLLQIQMRDLEGYRETRYQLLQLRPTQ-RASWIGYAIAYHlLKDYDMALKLLEEFRqtqqvppnKIDYEYSELILYQN 197
Cdd:TIGR02917 232 ALATILIEAGEFEEAEKHADALLKKAPNSpLAHYLKALVDFQ-KKNYEDARETLQDAL--------KSAPEYLPALLLAG 302

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462537971 198 QVMREADLLQESLEHIEMYEKQICDKLLVEEIKGEILLKLGRLKEASEVFKNLIDRNAEN 257
Cdd:TIGR02917 303 ASEYQLGNLEQAYQYLNQILKYAPNSHQARRLLASIQLRLGRVDEAIATLSPALGLDPDD 362
TPR_1 pfam00515
Tetratricopeptide repeat;
87-113 1.17e-03

Tetratricopeptide repeat;


Pssm-ID: 459840 [Multi-domain]  Cd Length: 34  Bit Score: 35.86  E-value: 1.17e-03
                          10        20
                  ....*....|....*....|....*..
gi 2462537971  87 GLLQRSDKKYDEAIKCYRNALKLDKDN 113
Cdd:pfam00515   8 GNAYFKLGKYDEALEYYEKALELNPNN 34
TPR smart00028
Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum ...
 87-113 6.52e-03

Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum of 34 amino acids each and self-associate via a "knobs and holes" mechanism.


Pssm-ID: 197478 [Multi-domain]  Cd Length: 34  Bit Score: 33.96  E-value: 6.52e-03
                           10        20
                   ....*....|....*....|....*..
gi 2462537971   87 GLLQRSDKKYDEAIKCYRNALKLDKDN 113
Cdd:smart00028   8 GNAYLKLGDYDEALEYYEKALELDPNN 34
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 94-290 9.96e-03

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 37.76  E-value: 9.96e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462537971  94 KKYDEAIKCYRNALKLDKDNLQILRDLSLLQIQMRDLEGYREtRYQ-LLQLRPTQRASWIGYAIAYHLLKDYDMALKLLE 172
Cdd:TIGR02917 479 GDLAKAREAFEKALSIEPDFFPAAANLARIDIQEGNPDDAIQ-RFEkVLTIDPKNLRAILALAGLYLRTGNEEEAVAWLE 557

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462537971 173 EfrqtqqvpPNKIDYEYSELILYQNQVMREADLLQESLEHIEMYEKQICDKLLVEEIKGEILLKLGRLKEASEVFKNLID 252
Cdd:TIGR02917 558 K--------AAELNPQEIEPALALAQYYLGKGQLKKALAILNEAADAAPDSPEAWLMLGRAQLAAGDLNKAVSSFKKLLA 629

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462537971 253 RNAENWCYY-----------------EGLEKALQI------------------STLEERLQIYEEISKQHPKA 290
Cdd:TIGR02917 630 LQPDSALALllladayavmknyakaiTSLKRALELkpdnteaqiglaqlllaaKRTESAKKIAKSLQKQHPKA 702
 
Name Accession Description Interval E-value
NatA_aux_su pfam12569
N-terminal acetyltransferase A, auxiliary subunit; This entry represents N-terminal ...
 187-338 8.77e-66

N-terminal acetyltransferase A, auxiliary subunit; This entry represents N-terminal acetyltransferase A (NatA) auxiliary subunit (also known as NMDA receptor-regulated protein 1), which is a non-catalytic component of the NatA N-terminal acetyltransferase that catalyzes acetylation of proteins beginning with Met-Ser, Met-Gly and Met-Ala. N-terminal acetylation plays a role in normal eukaryotic translation and processing, protecting against proteolytic degradation and protein turnover. NAT1 anchors ARD1 and NAT5 to the ribosome, and may present the N terminus of nascent polypeptides for acetylation.


Pssm-ID: 463630 [Multi-domain]  Cd Length: 514  Bit Score: 215.60  E-value: 8.77e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462537971 187 YEYSELILYQNQVMREADLLQESLEHIEMYEKQICDKLLVEEIKGEILLKLGRLKEASEVFKNLIDRNAENWCYYEGLEK 266
Cdd:pfam12569   1 YEHSELLLYKNQIIAESGDLEEALEHLEKVEKQIVDKLAVLETKADYLLKLGRKEEAEATYRALLERNPENHAYYEGLEK 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2462537971 267 ALQIST--LEERLQIYEEISKQHPKAITPRRLPLTLVPGERFRELMDKFLRVNFSKGCPPLFTTLKSLYYNTEK 338
Cdd:pfam12569  81 ALGISKedHEALLALYDELAEKYPRSDAPRRLPLDFLEGEEFKELADKYLRRMLRKGVPSLFVNLKSLYTDSEK 154
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
21-243 7.09e-15

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 73.12  E-value: 7.09e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462537971  21 YEQKQYKNGLKFCKMILS-NPKFAEhgeTLAMKGLTLNCLGKKEEAYEFVRKGLRNDVKSHVCWHVYGLLQRSDKKYDEA 99
Cdd:COG0457    19 RRLGRYEEAIEDYEKALElDPDDAE---ALYNLGLAYLRLGRYEEALADYEQALELDPDDAEALNNLGLALQALGRYEEA 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462537971 100 IKCYRNALKLDKDNLQILRDLSLLQIQMRDLEGYRETRYQLLQLRPTQRASWIGYAIAYHLLKDYDMALKLLEEFRQTQQ 179
Cdd:COG0457    96 LEDYDKALELDPDDAEALYNLGLALLELGRYDEAIEAYERALELDPDDADALYNLGIALEKLGRYEEALELLEKLEAAAL 175

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2462537971 180 VPPNKIDYEYSELILYQNQVMREADLLQESLEHIEMYEKQICDKLLVEEIKGEILLKLGRLKEA 243
Cdd:COG0457   176 AALLAAALGEAALALAAAEVLLALLLALEQALRKKLAILTLAALAELLLLALALLLALRLAALA 239
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
44-283 3.94e-14

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 71.19  E-value: 3.94e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462537971  44 EHGETLAMKGLTLNCLGKKEEAYEFVRKGLRNDVKSHVCWHVYGLLQRSDKKYDEAIKCYRNALKLDKDNLQILRDLSLL 123
Cdd:COG0457     6 DDAEAYNNLGLAYRRLGRYEEAIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEALNNLGLA 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462537971 124 QIQMRDLEGYRETRYQLLQLRPTQRASWIGYAIAYHLLKDYDMALKLLEEFRQtqqvppnkIDYEYSELILYQNQVMREA 203
Cdd:COG0457    86 LQALGRYEEALEDYDKALELDPDDAEALYNLGLALLELGRYDEAIEAYERALE--------LDPDDADALYNLGIALEKL 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462537971 204 DLLQESLEHIEMYEKQICDKLLVEEIKGEILLKLGRLKEASEVFKNLIDRNAENWCYYEGLEKALQISTLEERLQIYEEI 283
Cdd:COG0457   158 GRYEEALELLEKLEAAALAALLAAALGEAALALAAAEVLLALLLALEQALRKKLAILTLAALAELLLLALALLLALRLAA 237
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 12-218 5.62e-13

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 69.64  E-value: 5.62e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462537971  12 NLFKRILKCYEQKQYKNGLKFCKMILS-NPKFAEHGETLamkGLTLNCLGKKEEAYEFVRKGLRNDVKSHVCWHVYGLLQ 90
Cdd:COG3914    80 LLELAALLLQALGRYEEALALYRRALAlNPDNAEALFNL---GNLLLALGRLEEALAALRRALALNPDFAEAYLNLGEAL 156

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462537971  91 RSDKKYDEAIKCYRNALKLDKDNLQILRDLSLLQIQMRDLEGYRETRYQLLQLRPTQRASWIGYAIAYHLLKDYDMALKL 170
Cdd:COG3914   157 RRLGRLEEAIAALRRALELDPDNAEALNNLGNALQDLGRLEEAIAAYRRALELDPDNADAHSNLLFALRQACDWEVYDRF 236

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 2462537971 171 LEEFRQTQQVPPNKIDYeyseLILYQNQVmREADLLQESLEHIEMYEK 218
Cdd:COG3914   237 EELLAALARGPSELSPF----ALLYLPDD-DPAELLALARAWAQLVAA 279
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 44-287 1.64e-12

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 66.68  E-value: 1.64e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462537971  44 EHGETLAMKGLTLNCLGKKEEAYEFVRKGLRNDVKSHVCWHVYGLLQRSDKKYDEAIKCYRNALKLDKDNLQILRDLSLL 123
Cdd:COG2956    40 ETVEAHLALGNLYRRRGEYDRAIRIHQKLLERDPDRAEALLELAQDYLKAGLLDRAEELLEKLLELDPDDAEALRLLAEI 119

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462537971 124 QIQMRDLEGYRETRYQLLQLRPTQRASWIGYAIAYHLLKDYDMALKLLEEFRqtqqvppnKIDYEYSELILYQNQVMREA 203
Cdd:COG2956   120 YEQEGDWEKAIEVLERLLKLGPENAHAYCELAELYLEQGDYDEAIEALEKAL--------KLDPDCARALLLLAELYLEQ 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462537971 204 DLLQESLEHIEMYEKQICDKLLVEEIKGEILLKLGRLKEASEVFKNLIDRNAENWCYYEGLEKALQISTLEERLQIYEEI 283
Cdd:COG2956   192 GDYEEAIAALERALEQDPDYLPALPRLAELYEKLGDPEEALELLRKALELDPSDDLLLALADLLERKEGLEAALALLERQ 271


                  ....
gi 2462537971 284 SKQH 287
Cdd:COG2956   272 LRRH 275
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 43-220 5.85e-11

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 63.47  E-value: 5.85e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462537971  43 AEHGETLAMKGLTLNCLGKKEEAYEFVRKGLRNDVKSHVCWHVYGLLQRSDKKYDEAIKCYRNALKLDKDNLQILRDLSL 122
Cdd:COG3914    75 LLLAALLELAALLLQALGRYEEALALYRRALALNPDNAEALFNLGNLLLALGRLEEALAALRRALALNPDFAEAYLNLGE 154

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462537971 123 LQIQMRDLEGYRETRYQLLQLRPTQRASWIGYAIAYHLLKDYDMAlklLEEFRQTQQVPPNKIDYEYSEL-ILYQNQVMR 201
Cdd:COG3914   155 ALRRLGRLEEAIAALRRALELDPDNAEALNNLGNALQDLGRLEEA---IAAYRRALELDPDNADAHSNLLfALRQACDWE 231

                         170
                  ....*....|....*....
gi 2462537971 202 EADLLQESLEHIEMYEKQI 220
Cdd:COG3914   232 VYDRFEELLAALARGPSEL 250
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 64-193 3.60e-10

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 57.32  E-value: 3.60e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462537971  64 EAYEFVRKGLRNDVKSHVCWHVYGLLQRSDKKYDEAIKCYRNALKLDKDNLQILRDLSLLQIQMRDLEGYRETRYQLLQL 143
Cdd:COG4235     1 EAIARLRQALAANPNDAEGWLLLGRAYLRLGRYDEALAAYEKALRLDPDNADALLDLAEALLAAGDTEEAEELLERALAL 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 2462537971 144 RPTQRASWIGYAIAYHLLKDYDMALKLLEEFRqtQQVPPNKIDYEYSELI 193
Cdd:COG4235    81 DPDNPEALYLLGLAAFQQGDYAEAIAAWQKLL--ALLPADAPARLLEASI 128
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
73-279 5.32e-10

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 58.86  E-value: 5.32e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462537971  73 LRNDVKSHVCWHVYGLLQRSDKKYDEAIKCYRNALKLDKDNLQILRDLSLLQIQMRDLEGYRETRYQLLQLRPTQRASWI 152
Cdd:COG0457     1 LELDPDDAEAYNNLGLAYRRLGRYEEAIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEALN 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462537971 153 GYAIAYHLLKDYDMALKLLEEFRQtqqvppnkIDYEYSELILYQNQVMREADLLQESLEHIEMYEKQICDKLLVEEIKGE 232
Cdd:COG0457    81 NLGLALQALGRYEEALEDYDKALE--------LDPDDAEALYNLGLALLELGRYDEAIEAYERALELDPDDADALYNLGI 152

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 2462537971 233 ILLKLGRLKEASEVFKNLIDRNAENWCYYEGLEKALQISTLEERLQI 279
Cdd:COG0457   153 ALEKLGRYEEALELLEKLEAAALAALLAAALGEAALALAAAEVLLAL 199
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 83-291 1.17e-09

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 58.20  E-value: 1.17e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462537971  83 WHVYGLLQRSDKKYDEAIKCYRNALKLDKDNLQILRDLSLLQIQMRDLEGYRETRYQLLQLRPTQRASWIGYAIAYHLLK 162
Cdd:COG2956    11 WYFKGLNYLLNGQPDKAIDLLEEALELDPETVEAHLALGNLYRRRGEYDRAIRIHQKLLERDPDRAEALLELAQDYLKAG 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462537971 163 DYDMALKLLEEFRQTqqvPPNKIDYEYSELILYQnqvmREADlLQESLEHIEMYEKQICDKLLVEEIKGEILLKLGRLKE 242
Cdd:COG2956    91 LLDRAEELLEKLLEL---DPDDAEALRLLAEIYE----QEGD-WEKAIEVLERLLKLGPENAHAYCELAELYLEQGDYDE 162

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 2462537971 243 ASEVFKNLIDRNAENWCYYEGLEK-ALQISTLEERLQIYEEISKQHPKAI 291
Cdd:COG2956   163 AIEALEKALKLDPDCARALLLLAElYLEQGDYEEAIAALERALEQDPDYL 212
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
21-211 1.31e-09

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 57.71  E-value: 1.31e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462537971  21 YEQKQYKNGLKFCKMILS-NPKFAEhgeTLAMKGLTLNCLGKKEEAYEFVRKGLRNDVKSHVCWHVYGLLQRSDKKYDEA 99
Cdd:COG0457    53 LRLGRYEEALADYEQALElDPDDAE---ALNNLGLALQALGRYEEALEDYDKALELDPDDAEALYNLGLALLELGRYDEA 129

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462537971 100 IKCYRNALKLDKDNLQILRDLSLLQIQMRDLEGYRETRYQLLQLRPTQRASWIGYAIAYHLLKDYDMALKLLEEFRQTQQ 179
Cdd:COG0457   130 IEAYERALELDPDDADALYNLGIALEKLGRYEEALELLEKLEAAALAALLAAALGEAALALAAAEVLLALLLALEQALRK 209

                         170       180       190
                  ....*....|....*....|....*....|..
gi 2462537971 180 VPPNKIDYEYSELILYQNQVMREADLLQESLE 211
Cdd:COG0457   210 KLAILTLAALAELLLLALALLLALRLAALALY 241
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 43-173 2.89e-09

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 54.81  E-value: 2.89e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462537971  43 AEHGETLAMKGLTLNCLGKKEEAYEFVRKGLRNDVKSHVCWHVYGLLQRSDKKYDEAIKCYRNALKLDKDNLQILRDLSL 122
Cdd:COG4783     1 AACAEALYALAQALLLAGDYDEAEALLEKALELDPDNPEAFALLGEILLQLGDLDEAIVLLHEALELDPDEPEARLNLGL 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2462537971 123 LQIQMRDLEGYRETRYQLLQLRPTQRASWIGYAIAYHLLKDYDMALKLLEE 173
Cdd:COG4783    81 ALLKAGDYDEALALLEKALKLDPEHPEAYLRLARAYRALGRPDEAIAALEK 131
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 21-147 4.39e-09

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 54.43  E-value: 4.39e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462537971  21 YEQKQYKNGLKFCKMILSnpKFAEHGETLAMKGLTLNCLGKKEEAYEFVRKGLRNDVKSHVCWHVYGLLQRSDKKYDEAI 100
Cdd:COG4783    15 LLAGDYDEAEALLEKALE--LDPDNPEAFALLGEILLQLGDLDEAIVLLHEALELDPDEPEARLNLGLALLKAGDYDEAL 92

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 2462537971 101 KCYRNALKLDKDNLQILRDLSLLQIQMRDLEGYRETRYQLLQLRPTQ 147
Cdd:COG4783    93 ALLEKALKLDPEHPEAYLRLARAYRALGRPDEAIAALEKALELDPDD 139
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 86-257 2.09e-08

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 52.50  E-value: 2.09e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462537971  86 YGLLQRSDKKYDEAIKCYRNALKLDKDNLQILRDLSLLQIQMRDLEGYRETRYQLLQLRPTQRASWIGYAIAYHLLKDYD 165
Cdd:COG4783    10 LAQALLLAGDYDEAEALLEKALELDPDNPEAFALLGEILLQLGDLDEAIVLLHEALELDPDEPEARLNLGLALLKAGDYD 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462537971 166 MALKLLEEfrqtqqvppnkidyeyselilyqnqvmreadLLQESLEHIEMYEKqicdkllveeiKGEILLKLGRLKEASE 245
Cdd:COG4783    90 EALALLEK-------------------------------ALKLDPEHPEAYLR-----------LARAYRALGRPDEAIA 127

                         170
                  ....*....|..
gi 2462537971 246 VFKNLIDRNAEN 257
Cdd:COG4783   128 ALEKALELDPDD 139
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 86-173 4.14e-08

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 51.88  E-value: 4.14e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462537971  86 YGLLQRSDKKYDEAIKCYRNALKLDKDNLQILRDLSLLQIQMRDLEGYRETRYQLLQLRPTQRASWIGYAIAYHLLKDYD 165
Cdd:COG5010    60 SDNLYNKLGDFEESLALLEQALQLDPNNPELYYNLALLYSRSGDKDEAKEYYEKALALSPDNPNAYSNLAALLLSLGQDD 139


                  ....*...
gi 2462537971 166 MALKLLEE 173
Cdd:COG5010   140 EAKAALQR 147
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 6-173 6.96e-08

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 52.81  E-value: 6.96e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462537971   6 LPPKESNLFKRILKCYEQ-KQYKNGLKFCKMILSNPKFAEHgeTLAMKGLTLNCLGKKEEAYEFVRKGLRNDVKSHVCWH 84
Cdd:COG2956   105 LDPDDAEALRLLAEIYEQeGDWEKAIEVLERLLKLGPENAH--AYCELAELYLEQGDYDEAIEALEKALKLDPDCARALL 182

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462537971  85 VYGLLQRSDKKYDEAIKCYRNALKLDKDNLQILRDLSLLQIQMRDLEGYRETRYQLLQLRPtQRASWIGYAIAYHLLKDY 164
Cdd:COG2956   183 LLAELYLEQGDYEEAIAALERALEQDPDYLPALPRLAELYEKLGDPEEALELLRKALELDP-SDDLLLALADLLERKEGL 261


                  ....*....
gi 2462537971 165 DMALKLLEE 173
Cdd:COG2956   262 EAALALLER 270
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
87-189 2.72e-07

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 50.68  E-value: 2.72e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462537971  87 GLLQRSDKKYDEAIKCYRNALKLDKDNLQILRDLSLLQIQMRDLEG----YRETryqlLQLRPTQRASWIGYAIAYHLLK 162
Cdd:COG4785    80 GVAYDSLGDYDLAIADFDQALELDPDLAEAYNNRGLAYLLLGDYDAaledFDRA----LELDPDYAYAYLNRGIALYYLG 155

                          90       100
                  ....*....|....*....|....*..
gi 2462537971 163 DYDMALKLLEEFRQTQQVPPNKIDYEY 189
Cdd:COG4785   156 RYELAIADLEKALELDPNDPERALWLY 182
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 39-257 2.88e-07

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 52.01  E-value: 2.88e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462537971  39 NPKFAEHGETLAMKGLTLNclgKKEEAYEFVRKGLRNDVKSHVCWHVYGLLQRSDKKYDEAIKCYRNALKLDKDNLQILR 118
Cdd:TIGR02917 155 DPRSLYAKLGLAQLALAEN---RFDEARALIDEVLTADPGNVDALLLKGDLLLSLGNIELALAAYRKAIALRPNNIAVLL 231

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462537971 119 DLSLLQIQMRDLEGYRETRYQLLQLRPTQ-RASWIGYAIAYHlLKDYDMALKLLEEFRqtqqvppnKIDYEYSELILYQN 197
Cdd:TIGR02917 232 ALATILIEAGEFEEAEKHADALLKKAPNSpLAHYLKALVDFQ-KKNYEDARETLQDAL--------KSAPEYLPALLLAG 302

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462537971 198 QVMREADLLQESLEHIEMYEKQICDKLLVEEIKGEILLKLGRLKEASEVFKNLIDRNAEN 257
Cdd:TIGR02917 303 ASEYQLGNLEQAYQYLNQILKYAPNSHQARRLLASIQLRLGRVDEAIATLSPALGLDPDD 362
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 54-145 2.96e-07

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 49.57  E-value: 2.96e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462537971  54 LTLNCLGKKEEAYEFVRKGLRNDVKSHVCWHVYGLLQRSDKKYDEAIKCYRNALKLDKDNLQILRDLSLLQIQMRDLEGY 133
Cdd:COG5010    62 NLYNKLGDFEESLALLEQALQLDPNNPELYYNLALLYSRSGDKDEAKEYYEKALALSPDNPNAYSNLAALLLSLGQDDEA 141

                          90
                  ....*....|..
gi 2462537971 134 RETRYQLLQLRP 145
Cdd:COG5010   142 KAALQRALGTSP 153
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
89-178 5.79e-07

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 47.09  E-value: 5.79e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462537971  89 LQRSDKKYDEAIKCYRNALKLDKDNLQILRDLSLLQIQMRDLEGYRETRyQLLQLRPTQRASWIGYAIAYHLLKDYDMAL 168
Cdd:COG3063     1 LYLKLGDLEEAEEYYEKALELDPDNADALNNLGLLLLEQGRYDEAIALE-KALKLDPNNAEALLNLAELLLELGDYDEAL 79

                          90
                  ....*....|
gi 2462537971 169 KLLEEFRQTQ 178
Cdd:COG3063    80 AYLERALELD 89
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
59-149 1.35e-06

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 45.93  E-value: 1.35e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462537971  59 LGKKEEAYEFVRKGLRNDVKSHVCWHVYGLLQRSDKKYDEAIKcYRNALKLDKDNLQILRDLSLLQIQMRDLEGYRETRY 138
Cdd:COG3063     5 LGDLEEAEEYYEKALELDPDNADALNNLGLLLLEQGRYDEAIA-LEKALKLDPNNAEALLNLAELLLELGDYDEALAYLE 83

                          90
                  ....*....|.
gi 2462537971 139 QLLQLRPTQRA 149
Cdd:COG3063    84 RALELDPSALR 94
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 147-289 6.55e-05

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 42.49  E-value: 6.55e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462537971 147 QRASWIGYAIAYHLLKDYDMALKLLEEFRQTQqvPPNKIDYEYSELILYQNQVMREA-DLLQESLEHIEmyekqicDKLL 225
Cdd:COG4783     3 CAEALYALAQALLLAGDYDEAEALLEKALELD--PDNPEAFALLGEILLQLGDLDEAiVLLHEALELDP-------DEPE 73

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2462537971 226 VEEIKGEILLKLGRLKEASEVFKNLIDRNAENWCYYEGLEKALQ-ISTLEERLQIYEEISKQHPK 289
Cdd:COG4783    74 ARLNLGLALLKAGDYDEALALLEKALKLDPEHPEAYLRLARAYRaLGRPDEAIAALEKALELDPD 138
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 60-210 1.69e-04

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 43.53  E-value: 1.69e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462537971  60 GKKEEAYEFVRKGLRNDVKSHVCWHVYGLLQRSDKKYDEAIKCYRNALKLDKDNLQILRDLSLLQIQMRDLE--GYRETR 137
Cdd:TIGR02917 750 GNTAEAVKTLEAWLKTHPNDAVLRTALAELYLAQKDYDKAIKHYQTVVKKAPDNAVVLNNLAWLYLELKDPRalEYAERA 829

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2462537971 138 yqlLQLRPTQRASWIGYAIAYHLLKDYDMALKLLEefRQTQQVPPN-KIDYEYSELILYQNQVMREADLLQESL 210
Cdd:TIGR02917 830 ---LKLAPNIPAILDTLGWLLVEKGEADRALPLLR--KAVNIAPEAaAIRYHLALALLATGRKAEARKELDKLL 898
TPR_1 pfam00515
Tetratricopeptide repeat;
87-113 1.17e-03

Tetratricopeptide repeat;


Pssm-ID: 459840 [Multi-domain]  Cd Length: 34  Bit Score: 35.86  E-value: 1.17e-03
                          10        20
                  ....*....|....*....|....*..
gi 2462537971  87 GLLQRSDKKYDEAIKCYRNALKLDKDN 113
Cdd:pfam00515   8 GNAYFKLGKYDEALEYYEKALELNPNN 34
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 91-253 1.71e-03

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 40.07  E-value: 1.71e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462537971  91 RSDKKYDEAIKCYRNALKLDKDNLQILRDLSLLQIQMRDLEGYRETRYQLLQLRPTQRASWIGYAIAYHLLKDYDMALKl 170
Cdd:TIGR02917 578 LGKGQLKKALAILNEAADAAPDSPEAWLMLGRAQLAAGDLNKAVSSFKKLLALQPDSALALLLLADAYAVMKNYAKAIT- 656

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462537971 171 leEFRQTQQVPPNkidyeYSELILYQNQVMREADLLQESLEHIEMYEKQICDKLLVEEIKGEILLKLGRLKEASEVFKNL 250
Cdd:TIGR02917 657 --SLKRALELKPD-----NTEAQIGLAQLLLAAKRTESAKKIAKSLQKQHPKAALGFELEGDLYLRQKDYPAAIQAYRKA 729


                  ...
gi 2462537971 251 IDR 253
Cdd:TIGR02917 730 LKR 732
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 83-289 2.43e-03

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 39.68  E-value: 2.43e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462537971  83 WHVYGLLQRSDKKYDEAIKCYRNALKLDKDNLQILRDLSLLQIQMRDLEGYRETRYQLLQLRPTQRASWIGYAIAYHLLK 162
Cdd:TIGR02917 604 WLMLGRAQLAAGDLNKAVSSFKKLLALQPDSALALLLLADAYAVMKNYAKAITSLKRALELKPDNTEAQIGLAQLLLAAK 683

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462537971 163 DYDMALKLLEEFRQTQQVPPNKIDYEYSeliLYqnqvMREADLLQESLEHIEMYEKQICDKLLVEeiKGEILLKLGRLKE 242
Cdd:TIGR02917 684 RTESAKKIAKSLQKQHPKAALGFELEGD---LY----LRQKDYPAAIQAYRKALKRAPSSQNAIK--LHRALLASGNTAE 754

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 2462537971 243 ASEVFKNLIDRNAENWC--YYEGlEKALQISTLEERLQIYEEISKQHPK 289
Cdd:TIGR02917 755 AVKTLEAWLKTHPNDAVlrTALA-ELYLAQKDYDKAIKHYQTVVKKAPD 802
TPR_11 pfam13414
TPR repeat;
95-127 4.71e-03

TPR repeat;


Pssm-ID: 315977 [Multi-domain]  Cd Length: 42  Bit Score: 34.37  E-value: 4.71e-03
                          10        20        30
                  ....*....|....*....|....*....|...
gi 2462537971  95 KYDEAIKCYRNALKLDKDNLQILRDLSLLQIQM 127
Cdd:pfam13414   9 KYEEAIEAYKKALKLDPDNPEAYYNLGLAYYKL 41
TPR smart00028
Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum ...
 87-113 6.52e-03

Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum of 34 amino acids each and self-associate via a "knobs and holes" mechanism.


Pssm-ID: 197478 [Multi-domain]  Cd Length: 34  Bit Score: 33.96  E-value: 6.52e-03
                           10        20
                   ....*....|....*....|....*..
gi 2462537971   87 GLLQRSDKKYDEAIKCYRNALKLDKDN 113
Cdd:smart00028   8 GNAYLKLGDYDEALEYYEKALELDPNN 34
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
44-115 8.19e-03

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 35.15  E-value: 8.19e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462537971  44 EHGETLAMKGLTLNCLGKKEEAYEFvRKGLRNDVKSHVCWHVYGLLQRSDKKYDEAIKCYRNALKLDKDNLQ 115
Cdd:COG3063    24 DNADALNNLGLLLLEQGRYDEAIAL-EKALKLDPNNAEALLNLAELLLELGDYDEALAYLERALELDPSALR 94
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 94-290 9.96e-03

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 37.76  E-value: 9.96e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462537971  94 KKYDEAIKCYRNALKLDKDNLQILRDLSLLQIQMRDLEGYREtRYQ-LLQLRPTQRASWIGYAIAYHLLKDYDMALKLLE 172
Cdd:TIGR02917 479 GDLAKAREAFEKALSIEPDFFPAAANLARIDIQEGNPDDAIQ-RFEkVLTIDPKNLRAILALAGLYLRTGNEEEAVAWLE 557

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462537971 173 EfrqtqqvpPNKIDYEYSELILYQNQVMREADLLQESLEHIEMYEKQICDKLLVEEIKGEILLKLGRLKEASEVFKNLID 252
Cdd:TIGR02917 558 K--------AAELNPQEIEPALALAQYYLGKGQLKKALAILNEAADAAPDSPEAWLMLGRAQLAAGDLNKAVSSFKKLLA 629

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462537971 253 RNAENWCYY-----------------EGLEKALQI------------------STLEERLQIYEEISKQHPKA 290
Cdd:TIGR02917 630 LQPDSALALllladayavmknyakaiTSLKRALELkpdnteaqiglaqlllaaKRTESAKKIAKSLQKQHPKA 702
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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