|
Name |
Accession |
Description |
Interval |
E-value |
| TROVE |
pfam05731 |
TROVE domain; This presumed domain is found in TEP1 and Ro60 proteins, that are RNA-binding ... |
226-676 |
9.27e-152 |
|
TROVE domain; This presumed domain is found in TEP1 and Ro60 proteins, that are RNA-binding components of Telomerase, Ro and Vault RNPs. This domain has been named TROVE, (after Telomerase, Ro and Vault). This domain is probably RNA-binding.
:
Pssm-ID: 461724 Cd Length: 361 Bit Score: 475.34 E-value: 9.27e-152
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462541457 226 TSGDSESHPEPTDHVLQEKKMALLSLLCST---LVSEVNMNNTS------DPTLAAIFEICREL-----ALLEPEFILKA 291
Cdd:pfam05731 1 VSNDSGGYPEPTDDVLQEKRFLLLGLLCGTyytLASEVTMDNAQaikiieDGTGASILETLRELsaagrAPKEPEFILKL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462541457 292 SLYARQQLNVRNVANNILAIAAFLPACRphlrryfcaivqLPSDWIQVAELYQSLAEGDKNKLVPLPACLRTAMTD---- 367
Cdd:pfam05731 81 ALYARQQLNIRDVANHVLAIAAVLPVCR------------LPTDLFEVAEYCEELAEGDEKKLTGWGRCLRRAMTDwyts 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462541457 368 KFAQFDEYQLAKYNPRKHRAKRHPRRPPRspgmePPFSHR---CFPRYIGFLREEQRKFEKAGDTVSEKKNPPRFTLKKL 444
Cdd:pfam05731 149 KFAEFLAYQLTKYNTRKHWSHKDPFRLPH-----PPKFSEtslELKGLFRYATKEQRKFEKAYGAVPEKKESKRLTLKKL 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462541457 445 VQRLHIHKPAQHVQALLGYRYpsnlqlfsrsRLpgpwdssragkrmklsrpeTWERELSLRGNKASVWEELIENgKLPFM 524
Cdd:pfam05731 224 VQRLHISEPAEHVQALIGKRY----------RL-------------------TWEREPSLRGNSAEVWEELIDS-KLPMM 273
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462541457 525 AMLRNLCNLLRVGISSRHHE-LILQRLQHAKSVIHSRQFPFRFLNAHdaidaleaqlrnqalpfpsnitlmrriltrnek 603
Cdd:pfam05731 274 AMLRNLCNLLRVGVSARHHEdLVLQRLQNPKSVIHSRQHPFRFLNAH--------------------------------- 320
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462541457 604 nrprrrflchlsrqqlrmamripVLYEQLKREKLRvhkaRQWKYDGEMlnryRQALETAVNLSVKhSLPLLPG 676
Cdd:pfam05731 321 -----------------------VVYEQGKGEKGK----LQWKPDPEI----SQALEAAFYLAVK-NLPPTPG 361
|
|
| DUF5920 |
pfam19334 |
Domain of unknown function (DUF5920); This domain is found in the Telomerase protein component ... |
687-889 |
6.87e-138 |
|
Domain of unknown function (DUF5920); This domain is found in the Telomerase protein component 1 (TEP1) and it contains an homology region to the telomerase associated protein from Tetrahymena p80. TEP1 is a component of the telomerase ribonucleoprotein complex and is thought to be responsible for catalysing the addition of new telomeres to chromosomes. TEP1 is also a component of the vault particle, a cytoplasmic ribonucleoprotein complex, in which it is required for vault RNA stability and its association with the vault particle. This domain is localized between the TROVE (pfam05731) and DUF4062 (pfam13271) domains.
:
Pssm-ID: 466045 Cd Length: 203 Bit Score: 428.81 E-value: 6.87e-138
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462541457 687 NADRLCPKSNPQGPPLNYALLLIGMMITRAEQVDVVLCGGDTLKTAVLKAEEGILKTAIKLQAQVQEFDENDGWSLNTFG 766
Cdd:pfam19334 1 NADRLCPKSNPQGPPLNYVLLLIGMMIARAEQVDLLLCGRGTLKTAVLKAEEGILKTAIKLQAQVQELEENDEWPLTTFG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462541457 767 KYLLSLAGQRVPVDRVILLGQSMDDGMINVAKQLYWQRVNSKCLFVGILLRRVQYLSTDLNPNDVTLSGCTDAILKFIAE 846
Cdd:pfam19334 81 KYLLSLAVQRVPVDRVILFGQTMNERLINVAKQLFWQHVNSKCLFVGVLLRKTQYISPDLNPNDVTLSGCTDGILKFIAE 160
|
170 180 190 200
....*....|....*....|....*....|....*....|...
gi 2462541457 847 HGASHLLEHVGQMDKIFKIPPPPGKTGVQSLRPLEEDTPSPLA 889
Cdd:pfam19334 161 RGASRLLEHVGQMDKIFKIPPPPGKTGVLSLRPLEEDTPSPLA 203
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
1849-2268 |
8.20e-70 |
|
WD40 repeat [General function prediction only];
:
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 241.35 E-value: 8.20e-70
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462541457 1849 AFNVPGGVVAVGRLDSMVELWAWREGARLAAFPAHHGFVAAALFLHAGCQLLTAGEDGKVQVWSGSLGRPRGHLGSLSlS 1928
Cdd:COG2319 1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHT-A 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462541457 1929 PALSVALSPDGDRVAVGYRADGIRIYKISSGSQGAQGQALDVAVSALAWlSP--KVLVSGAEDGSLQGWALKecSLQSLW 2006
Cdd:COG2319 80 AVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAF-SPdgKTLASGSADGTVRLWDLA--TGKLLR 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462541457 2007 LLSRFQKPVLGLATSQ--ELLASASEDFTVQLWprqlltrphKAEDFPCGTELRGHEGPVSCCSFSTDGGSLATGGRDRS 2084
Cdd:COG2319 157 TLTGHSGAVTSVAFSPdgKLLASGSDDGTVRLW---------DLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGT 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462541457 2085 LLCWDVRTPKtpvLIHSFPAcHRDWVTGCAWTKDN-LLISCSSDGSVGLWDPESGQRLGQFLGHQSAVSAVA--AVEEHV 2161
Cdd:COG2319 228 VRLWDLATGK---LLRTLTG-HSGSVRSVAFSPDGrLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAfsPDGKLL 303
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462541457 2162 VSVSRDGTLKVWD-HQGVELTSIPAHSGPISHCAAAmeprAAGQpgselLVVTVGLDGATRLWHPLLVCQTHTLLGHSGP 2240
Cdd:COG2319 304 ASGSDDGTVRLWDlATGKLLRTLTGHTGAVRSVAFS----PDGK-----TLASGSDDGTVRLWDLATGELLRTLTGHTGA 374
|
410 420
....*....|....*....|....*...
gi 2462541457 2241 VRAAAVSETSGLMLTASEDGSVRLWQVP 2268
Cdd:COG2319 375 VTSVAFSPDGRTLASGSADGTVRLWDLA 402
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
1680-1958 |
1.84e-48 |
|
WD40 repeat [General function prediction only];
:
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 179.34 E-value: 1.84e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462541457 1680 TAVAFSTNGQRAAVGTANGTVYLLDLRTWQEEKSVVSGCDGISACLFLSDDTLFLTA-FDGLLELWDLQHGCRVLQTKAH 1758
Cdd:COG2319 124 RSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGsDDGTVRLWDLATGKLLRTLTGH 203
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462541457 1759 QYQITGCCLSPDCRLLATVCLGGCLKLWDTVRGQ-LAFQHTYPKSLNCVAFHPEGQVIATGSWAGSISFFQVDGLKVTKD 1837
Cdd:COG2319 204 TGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKlLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRT 283
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462541457 1838 LGAPGASIRTLAFNVPGGVVAVGRLDSMVELWAWREGARLAAFPAHHGFVAAALFLHAGCQLLTAGEDGKVQVWSGSLGR 1917
Cdd:COG2319 284 LTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGE 363
|
250 260 270 280
....*....|....*....|....*....|....*....|....*
gi 2462541457 1918 P----RGHLGslslsPALSVALSPDGDRVAVGYRADGIRIYKISS 1958
Cdd:COG2319 364 LlrtlTGHTG-----AVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
|
|
| NACHT |
pfam05729 |
NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in ... |
1162-1337 |
2.19e-32 |
|
NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in MHC transcription activation. This family is closely related to pfam00931.
:
Pssm-ID: 428606 [Multi-domain] Cd Length: 166 Bit Score: 124.72 E-value: 2.19e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462541457 1162 RLSLVTGQSGQGKTAFLASLVSALQAPDGAKVASLVFFHFSGARPDQGLAltllRRLCTYLRGQLKEPGALPSTYRSLVW 1241
Cdd:pfam05729 1 RTVILQGEAGSGKTTLLQKLALLWAQGKLPQGFDFVFFLPCRELSRSGNA----RSLADLLFSQWPEPAAPVSEVWAVIL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462541457 1242 ELQQRLLpksaeslhpgqtqvLIIDGADRLVDQNGQ---------LISDWIPKKLPRCVHLVLSVSSDAG--LGETLEQS 1310
Cdd:pfam05729 77 ELPERLL--------------LILDGLDELVSDLGQldgpcpvltLLSSLLRKKLLPGASLLLTVRPDALrdLRRGLEEP 142
|
170 180
....*....|....*....|....*..
gi 2462541457 1311 QgahVLALGPLEASARARLVREELALY 1337
Cdd:pfam05729 143 R---YLEVRGFSESDRKQYVRKYFSDE 166
|
|
| DUF4062 |
pfam13271 |
Domain of unknown function (DUF4062); This presumed domain is functionally uncharacterized. ... |
900-1008 |
1.04e-15 |
|
Domain of unknown function (DUF4062); This presumed domain is functionally uncharacterized. This domain family is found in bacteria, archaea and eukaryotes, and is approximately 80 amino acids in length. There is a conserved SST sequence motif.
:
Pssm-ID: 463823 Cd Length: 78 Bit Score: 74.16 E-value: 1.04e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462541457 900 RLFISSTFRDMHGERDLLLRSVlpalqaRAAPHrislhgidLRWGVTEEETRRNRQLEVCLGEVENAQLFVGILGSRYGY 979
Cdd:pfam13271 1 KVFISSTFYDLKEEREALIEAL------LELGH--------IPVGMEEFPASDESPLDVCLREVDECDIYILILGGRYGS 66
|
90 100
....*....|....*....|....*....
gi 2462541457 980 IPpsynlpdhphfhwaqqyPSGRSVTEME 1008
Cdd:pfam13271 67 ID-----------------PDGISYTELE 78
|
|
| TEP1_N |
pfam05386 |
TEP1 N-terminal domain; This short sequence region is found in four copies at the N-terminus ... |
1-29 |
8.83e-15 |
|
TEP1 N-terminal domain; This short sequence region is found in four copies at the N-terminus of the TEP1 telomerase component. The functional significance of the region is uncertain. However the conservation of two histidines and a cysteine suggests it is a potential zinc binding domain.
:
Pssm-ID: 428450 Cd Length: 29 Bit Score: 69.74 E-value: 8.83e-15
10 20
....*....|....*....|....*....
gi 2462541457 1 MEKLHGHVSAHPDILSLENRCLAMLPDLQ 29
Cdd:pfam05386 1 MEKPHGHVSAHPDILSLENRCLATLPDLK 29
|
|
| TEP1_N |
pfam05386 |
TEP1 N-terminal domain; This short sequence region is found in four copies at the N-terminus ... |
91-119 |
3.67e-14 |
|
TEP1 N-terminal domain; This short sequence region is found in four copies at the N-terminus of the TEP1 telomerase component. The functional significance of the region is uncertain. However the conservation of two histidines and a cysteine suggests it is a potential zinc binding domain.
:
Pssm-ID: 428450 Cd Length: 29 Bit Score: 68.20 E-value: 3.67e-14
10 20
....*....|....*....|....*....
gi 2462541457 91 MEKPHGHVSAHPDILSLENRCLATLSSLK 119
Cdd:pfam05386 1 MEKPHGHVSAHPDILSLENRCLATLPDLK 29
|
|
| TEP1_N |
pfam05386 |
TEP1 N-terminal domain; This short sequence region is found in four copies at the N-terminus ... |
61-89 |
1.51e-13 |
|
TEP1 N-terminal domain; This short sequence region is found in four copies at the N-terminus of the TEP1 telomerase component. The functional significance of the region is uncertain. However the conservation of two histidines and a cysteine suggests it is a potential zinc binding domain.
:
Pssm-ID: 428450 Cd Length: 29 Bit Score: 66.27 E-value: 1.51e-13
10 20
....*....|....*....|....*....
gi 2462541457 61 MEKPHGYVSAHPDILSLENQCLATLSDLK 89
Cdd:pfam05386 1 MEKPHGHVSAHPDILSLENRCLATLPDLK 29
|
|
| TEP1_N |
pfam05386 |
TEP1 N-terminal domain; This short sequence region is found in four copies at the N-terminus ... |
31-59 |
6.92e-12 |
|
TEP1 N-terminal domain; This short sequence region is found in four copies at the N-terminus of the TEP1 telomerase component. The functional significance of the region is uncertain. However the conservation of two histidines and a cysteine suggests it is a potential zinc binding domain.
:
Pssm-ID: 428450 Cd Length: 29 Bit Score: 61.65 E-value: 6.92e-12
10 20
....*....|....*....|....*....
gi 2462541457 31 LEKLHQHVSTHSDILSLKNQCLATLPDLK 59
Cdd:pfam05386 1 MEKPHGHVSAHPDILSLENRCLATLPDLK 29
|
|
| WD40 super family |
cl29593 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
2231-2391 |
2.55e-11 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
The actual alignment was detected with superfamily member cd00200:
Pssm-ID: 475233 [Multi-domain] Cd Length: 289 Bit Score: 66.97 E-value: 2.55e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462541457 2231 THTLLGHSGPVRAAAVSETSGLMLTASEDGSVRLWQVPKE-------------------ADDTCIPRSS----------- 2280
Cdd:cd00200 2 RRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGellrtlkghtgpvrdvaasADGTYLASGSsdktirlwdle 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462541457 2281 ------------AAVTAVAWAPDGSMAVSGNQAGELILWQEAKAVATAQAPGHIG---ALIWSSAHTfFVLSA--DEKIS 2343
Cdd:cd00200 82 tgecvrtltghtSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDwvnSVAFSPDGT-FVASSsqDGTIK 160
|
170 180 190 200
....*....|....*....|....*....|....*....|....*...
gi 2462541457 2344 EWQvkLRKGSAPGNLSLHLNRIlqedlgvlTSLDWAPDGHFLILAKAD 2391
Cdd:cd00200 161 LWD--LRTGKCVATLTGHTGEV--------NSVAFSPDGEKLLSSSSD 198
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| TROVE |
pfam05731 |
TROVE domain; This presumed domain is found in TEP1 and Ro60 proteins, that are RNA-binding ... |
226-676 |
9.27e-152 |
|
TROVE domain; This presumed domain is found in TEP1 and Ro60 proteins, that are RNA-binding components of Telomerase, Ro and Vault RNPs. This domain has been named TROVE, (after Telomerase, Ro and Vault). This domain is probably RNA-binding.
Pssm-ID: 461724 Cd Length: 361 Bit Score: 475.34 E-value: 9.27e-152
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462541457 226 TSGDSESHPEPTDHVLQEKKMALLSLLCST---LVSEVNMNNTS------DPTLAAIFEICREL-----ALLEPEFILKA 291
Cdd:pfam05731 1 VSNDSGGYPEPTDDVLQEKRFLLLGLLCGTyytLASEVTMDNAQaikiieDGTGASILETLRELsaagrAPKEPEFILKL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462541457 292 SLYARQQLNVRNVANNILAIAAFLPACRphlrryfcaivqLPSDWIQVAELYQSLAEGDKNKLVPLPACLRTAMTD---- 367
Cdd:pfam05731 81 ALYARQQLNIRDVANHVLAIAAVLPVCR------------LPTDLFEVAEYCEELAEGDEKKLTGWGRCLRRAMTDwyts 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462541457 368 KFAQFDEYQLAKYNPRKHRAKRHPRRPPRspgmePPFSHR---CFPRYIGFLREEQRKFEKAGDTVSEKKNPPRFTLKKL 444
Cdd:pfam05731 149 KFAEFLAYQLTKYNTRKHWSHKDPFRLPH-----PPKFSEtslELKGLFRYATKEQRKFEKAYGAVPEKKESKRLTLKKL 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462541457 445 VQRLHIHKPAQHVQALLGYRYpsnlqlfsrsRLpgpwdssragkrmklsrpeTWERELSLRGNKASVWEELIENgKLPFM 524
Cdd:pfam05731 224 VQRLHISEPAEHVQALIGKRY----------RL-------------------TWEREPSLRGNSAEVWEELIDS-KLPMM 273
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462541457 525 AMLRNLCNLLRVGISSRHHE-LILQRLQHAKSVIHSRQFPFRFLNAHdaidaleaqlrnqalpfpsnitlmrriltrnek 603
Cdd:pfam05731 274 AMLRNLCNLLRVGVSARHHEdLVLQRLQNPKSVIHSRQHPFRFLNAH--------------------------------- 320
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462541457 604 nrprrrflchlsrqqlrmamripVLYEQLKREKLRvhkaRQWKYDGEMlnryRQALETAVNLSVKhSLPLLPG 676
Cdd:pfam05731 321 -----------------------VVYEQGKGEKGK----LQWKPDPEI----SQALEAAFYLAVK-NLPPTPG 361
|
|
| DUF5920 |
pfam19334 |
Domain of unknown function (DUF5920); This domain is found in the Telomerase protein component ... |
687-889 |
6.87e-138 |
|
Domain of unknown function (DUF5920); This domain is found in the Telomerase protein component 1 (TEP1) and it contains an homology region to the telomerase associated protein from Tetrahymena p80. TEP1 is a component of the telomerase ribonucleoprotein complex and is thought to be responsible for catalysing the addition of new telomeres to chromosomes. TEP1 is also a component of the vault particle, a cytoplasmic ribonucleoprotein complex, in which it is required for vault RNA stability and its association with the vault particle. This domain is localized between the TROVE (pfam05731) and DUF4062 (pfam13271) domains.
Pssm-ID: 466045 Cd Length: 203 Bit Score: 428.81 E-value: 6.87e-138
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462541457 687 NADRLCPKSNPQGPPLNYALLLIGMMITRAEQVDVVLCGGDTLKTAVLKAEEGILKTAIKLQAQVQEFDENDGWSLNTFG 766
Cdd:pfam19334 1 NADRLCPKSNPQGPPLNYVLLLIGMMIARAEQVDLLLCGRGTLKTAVLKAEEGILKTAIKLQAQVQELEENDEWPLTTFG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462541457 767 KYLLSLAGQRVPVDRVILLGQSMDDGMINVAKQLYWQRVNSKCLFVGILLRRVQYLSTDLNPNDVTLSGCTDAILKFIAE 846
Cdd:pfam19334 81 KYLLSLAVQRVPVDRVILFGQTMNERLINVAKQLFWQHVNSKCLFVGVLLRKTQYISPDLNPNDVTLSGCTDGILKFIAE 160
|
170 180 190 200
....*....|....*....|....*....|....*....|...
gi 2462541457 847 HGASHLLEHVGQMDKIFKIPPPPGKTGVQSLRPLEEDTPSPLA 889
Cdd:pfam19334 161 RGASRLLEHVGQMDKIFKIPPPPGKTGVLSLRPLEEDTPSPLA 203
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
1849-2268 |
8.20e-70 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 241.35 E-value: 8.20e-70
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462541457 1849 AFNVPGGVVAVGRLDSMVELWAWREGARLAAFPAHHGFVAAALFLHAGCQLLTAGEDGKVQVWSGSLGRPRGHLGSLSlS 1928
Cdd:COG2319 1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHT-A 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462541457 1929 PALSVALSPDGDRVAVGYRADGIRIYKISSGSQGAQGQALDVAVSALAWlSP--KVLVSGAEDGSLQGWALKecSLQSLW 2006
Cdd:COG2319 80 AVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAF-SPdgKTLASGSADGTVRLWDLA--TGKLLR 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462541457 2007 LLSRFQKPVLGLATSQ--ELLASASEDFTVQLWprqlltrphKAEDFPCGTELRGHEGPVSCCSFSTDGGSLATGGRDRS 2084
Cdd:COG2319 157 TLTGHSGAVTSVAFSPdgKLLASGSDDGTVRLW---------DLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGT 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462541457 2085 LLCWDVRTPKtpvLIHSFPAcHRDWVTGCAWTKDN-LLISCSSDGSVGLWDPESGQRLGQFLGHQSAVSAVA--AVEEHV 2161
Cdd:COG2319 228 VRLWDLATGK---LLRTLTG-HSGSVRSVAFSPDGrLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAfsPDGKLL 303
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462541457 2162 VSVSRDGTLKVWD-HQGVELTSIPAHSGPISHCAAAmeprAAGQpgselLVVTVGLDGATRLWHPLLVCQTHTLLGHSGP 2240
Cdd:COG2319 304 ASGSDDGTVRLWDlATGKLLRTLTGHTGAVRSVAFS----PDGK-----TLASGSDDGTVRLWDLATGELLRTLTGHTGA 374
|
410 420
....*....|....*....|....*...
gi 2462541457 2241 VRAAAVSETSGLMLTASEDGSVRLWQVP 2268
Cdd:COG2319 375 VTSVAFSPDGRTLASGSADGTVRLWDLA 402
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
1972-2308 |
1.70e-55 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 196.02 E-value: 1.70e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462541457 1972 VSALAWL-SPKVLVSGAEDGSLQGWalkecSLQSLWLLSRFQ---KPVLGLATS--QELLASASEDFTVQLWPrqlltrp 2045
Cdd:cd00200 12 VTCVAFSpDGKLLATGSGDGTIKVW-----DLETGELLRTLKghtGPVRDVAASadGTYLASGSSDKTIRLWD------- 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462541457 2046 hkAEDFPCGTELRGHEGPVSCCSFSTDGGSLATGGRDRSLLCWDVRTPKtpvLIHSFPaCHRDWVTGCAWTKDNLLISCS 2125
Cdd:cd00200 80 --LETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGK---CLTTLR-GHTDWVNSVAFSPDGTFVASS 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462541457 2126 S-DGSVGLWDPESGQRLGQFLGHQSAVSAVAAV--EEHVVSVSRDGTLKVWDHQgveltsipahsgpishcaaamepraA 2202
Cdd:cd00200 154 SqDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSpdGEKLLSSSSDGTIKLWDLS-------------------------T 208
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462541457 2203 GQpgsellvvtvgldgatrlwhpllvcQTHTLLGHSGPVRAAAVSETSGLMLTASEDGSVRLWQVPKEADDTCIPRSSAA 2282
Cdd:cd00200 209 GK-------------------------CLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNS 263
|
330 340
....*....|....*....|....*.
gi 2462541457 2283 VTAVAWAPDGSMAVSGNQAGELILWQ 2308
Cdd:cd00200 264 VTSLAWSPDGKRLASGSADGTIRIWD 289
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
1680-1958 |
1.84e-48 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 179.34 E-value: 1.84e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462541457 1680 TAVAFSTNGQRAAVGTANGTVYLLDLRTWQEEKSVVSGCDGISACLFLSDDTLFLTA-FDGLLELWDLQHGCRVLQTKAH 1758
Cdd:COG2319 124 RSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGsDDGTVRLWDLATGKLLRTLTGH 203
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462541457 1759 QYQITGCCLSPDCRLLATVCLGGCLKLWDTVRGQ-LAFQHTYPKSLNCVAFHPEGQVIATGSWAGSISFFQVDGLKVTKD 1837
Cdd:COG2319 204 TGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKlLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRT 283
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462541457 1838 LGAPGASIRTLAFNVPGGVVAVGRLDSMVELWAWREGARLAAFPAHHGFVAAALFLHAGCQLLTAGEDGKVQVWSGSLGR 1917
Cdd:COG2319 284 LTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGE 363
|
250 260 270 280
....*....|....*....|....*....|....*....|....*
gi 2462541457 1918 P----RGHLGslslsPALSVALSPDGDRVAVGYRADGIRIYKISS 1958
Cdd:COG2319 364 LlrtlTGHTG-----AVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
1680-1955 |
1.96e-36 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 140.93 E-value: 1.96e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462541457 1680 TAVAFSTNGQRAAVGTANGTVYLLDLRTWQEEKSVVSGCDGISACLFLSDDTLFLTA-FDGLLELWDLQHGCRVLQTKAH 1758
Cdd:cd00200 13 TCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGsSDKTIRLWDLETGECVRTLTGH 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462541457 1759 QYQITGCCLSPDCRLLATVCLGGCLKLWDTVRGQLAF---QHTypKSLNCVAFHPEGQVIATGSWAGSISFFQVDGLKVT 1835
Cdd:cd00200 93 TSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTtlrGHT--DWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCV 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462541457 1836 KDLGAPGASIRTLAFNVPGGVVAVGRLDSMVELWAWREGARLAAFPAHHGFVAAALFLHAGCQLLTAGEDGKVQVWSGSL 1915
Cdd:cd00200 171 ATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRT 250
|
250 260 270 280
....*....|....*....|....*....|....*....|.
gi 2462541457 1916 GRPRGHLGSLSlSPALSVALSPDGDRVAVGYrADG-IRIYK 1955
Cdd:cd00200 251 GECVQTLSGHT-NSVTSLAWSPDGKRLASGS-ADGtIRIWD 289
|
|
| NACHT |
pfam05729 |
NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in ... |
1162-1337 |
2.19e-32 |
|
NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in MHC transcription activation. This family is closely related to pfam00931.
Pssm-ID: 428606 [Multi-domain] Cd Length: 166 Bit Score: 124.72 E-value: 2.19e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462541457 1162 RLSLVTGQSGQGKTAFLASLVSALQAPDGAKVASLVFFHFSGARPDQGLAltllRRLCTYLRGQLKEPGALPSTYRSLVW 1241
Cdd:pfam05729 1 RTVILQGEAGSGKTTLLQKLALLWAQGKLPQGFDFVFFLPCRELSRSGNA----RSLADLLFSQWPEPAAPVSEVWAVIL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462541457 1242 ELQQRLLpksaeslhpgqtqvLIIDGADRLVDQNGQ---------LISDWIPKKLPRCVHLVLSVSSDAG--LGETLEQS 1310
Cdd:pfam05729 77 ELPERLL--------------LILDGLDELVSDLGQldgpcpvltLLSSLLRKKLLPGASLLLTVRPDALrdLRRGLEEP 142
|
170 180
....*....|....*....|....*..
gi 2462541457 1311 QgahVLALGPLEASARARLVREELALY 1337
Cdd:pfam05729 143 R---YLEVRGFSESDRKQYVRKYFSDE 166
|
|
| DUF4062 |
pfam13271 |
Domain of unknown function (DUF4062); This presumed domain is functionally uncharacterized. ... |
900-1008 |
1.04e-15 |
|
Domain of unknown function (DUF4062); This presumed domain is functionally uncharacterized. This domain family is found in bacteria, archaea and eukaryotes, and is approximately 80 amino acids in length. There is a conserved SST sequence motif.
Pssm-ID: 463823 Cd Length: 78 Bit Score: 74.16 E-value: 1.04e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462541457 900 RLFISSTFRDMHGERDLLLRSVlpalqaRAAPHrislhgidLRWGVTEEETRRNRQLEVCLGEVENAQLFVGILGSRYGY 979
Cdd:pfam13271 1 KVFISSTFYDLKEEREALIEAL------LELGH--------IPVGMEEFPASDESPLDVCLREVDECDIYILILGGRYGS 66
|
90 100
....*....|....*....|....*....
gi 2462541457 980 IPpsynlpdhphfhwaqqyPSGRSVTEME 1008
Cdd:pfam13271 67 ID-----------------PDGISYTELE 78
|
|
| TEP1_N |
pfam05386 |
TEP1 N-terminal domain; This short sequence region is found in four copies at the N-terminus ... |
1-29 |
8.83e-15 |
|
TEP1 N-terminal domain; This short sequence region is found in four copies at the N-terminus of the TEP1 telomerase component. The functional significance of the region is uncertain. However the conservation of two histidines and a cysteine suggests it is a potential zinc binding domain.
Pssm-ID: 428450 Cd Length: 29 Bit Score: 69.74 E-value: 8.83e-15
10 20
....*....|....*....|....*....
gi 2462541457 1 MEKLHGHVSAHPDILSLENRCLAMLPDLQ 29
Cdd:pfam05386 1 MEKPHGHVSAHPDILSLENRCLATLPDLK 29
|
|
| TEP1_N |
pfam05386 |
TEP1 N-terminal domain; This short sequence region is found in four copies at the N-terminus ... |
91-119 |
3.67e-14 |
|
TEP1 N-terminal domain; This short sequence region is found in four copies at the N-terminus of the TEP1 telomerase component. The functional significance of the region is uncertain. However the conservation of two histidines and a cysteine suggests it is a potential zinc binding domain.
Pssm-ID: 428450 Cd Length: 29 Bit Score: 68.20 E-value: 3.67e-14
10 20
....*....|....*....|....*....
gi 2462541457 91 MEKPHGHVSAHPDILSLENRCLATLSSLK 119
Cdd:pfam05386 1 MEKPHGHVSAHPDILSLENRCLATLPDLK 29
|
|
| TEP1_N |
pfam05386 |
TEP1 N-terminal domain; This short sequence region is found in four copies at the N-terminus ... |
61-89 |
1.51e-13 |
|
TEP1 N-terminal domain; This short sequence region is found in four copies at the N-terminus of the TEP1 telomerase component. The functional significance of the region is uncertain. However the conservation of two histidines and a cysteine suggests it is a potential zinc binding domain.
Pssm-ID: 428450 Cd Length: 29 Bit Score: 66.27 E-value: 1.51e-13
10 20
....*....|....*....|....*....
gi 2462541457 61 MEKPHGYVSAHPDILSLENQCLATLSDLK 89
Cdd:pfam05386 1 MEKPHGHVSAHPDILSLENRCLATLPDLK 29
|
|
| TEP1_N |
pfam05386 |
TEP1 N-terminal domain; This short sequence region is found in four copies at the N-terminus ... |
31-59 |
6.92e-12 |
|
TEP1 N-terminal domain; This short sequence region is found in four copies at the N-terminus of the TEP1 telomerase component. The functional significance of the region is uncertain. However the conservation of two histidines and a cysteine suggests it is a potential zinc binding domain.
Pssm-ID: 428450 Cd Length: 29 Bit Score: 61.65 E-value: 6.92e-12
10 20
....*....|....*....|....*....
gi 2462541457 31 LEKLHQHVSTHSDILSLKNQCLATLPDLK 59
Cdd:pfam05386 1 MEKPHGHVSAHPDILSLENRCLATLPDLK 29
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
2231-2391 |
2.55e-11 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 66.97 E-value: 2.55e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462541457 2231 THTLLGHSGPVRAAAVSETSGLMLTASEDGSVRLWQVPKE-------------------ADDTCIPRSS----------- 2280
Cdd:cd00200 2 RRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGellrtlkghtgpvrdvaasADGTYLASGSsdktirlwdle 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462541457 2281 ------------AAVTAVAWAPDGSMAVSGNQAGELILWQEAKAVATAQAPGHIG---ALIWSSAHTfFVLSA--DEKIS 2343
Cdd:cd00200 82 tgecvrtltghtSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDwvnSVAFSPDGT-FVASSsqDGTIK 160
|
170 180 190 200
....*....|....*....|....*....|....*....|....*...
gi 2462541457 2344 EWQvkLRKGSAPGNLSLHLNRIlqedlgvlTSLDWAPDGHFLILAKAD 2391
Cdd:cd00200 161 LWD--LRTGKCVATLTGHTGEV--------NSVAFSPDGEKLLSSSSD 198
|
|
| WD40 |
smart00320 |
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ... |
2050-2089 |
1.79e-07 |
|
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.
Pssm-ID: 197651 [Multi-domain] Cd Length: 40 Bit Score: 49.23 E-value: 1.79e-07
10 20 30 40
....*....|....*....|....*....|....*....|
gi 2462541457 2050 DFPCGTELRGHEGPVSCCSFSTDGGSLATGGRDRSLLCWD 2089
Cdd:smart00320 1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
|
|
| PTZ00421 |
PTZ00421 |
coronin; Provisional |
1962-2199 |
4.25e-07 |
|
coronin; Provisional
Pssm-ID: 173611 [Multi-domain] Cd Length: 493 Bit Score: 55.28 E-value: 4.25e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462541457 1962 GAQGQALDVAVSALawlSPKVLVSGAEDGSLQGWALKECSLQSlwllsrfqkpvlglATSQELLasasedftvqlwprql 2041
Cdd:PTZ00421 73 GQEGPIIDVAFNPF---DPQKLFTASEDGTIMGWGIPEEGLTQ--------------NISDPIV---------------- 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462541457 2042 ltrphkaedfpcgtELRGHEGPVSCCSFSTDG-GSLATGGRDRSLLCWDVRTPKTPVLIhsfpACHRDWVTGCAWTKD-N 2119
Cdd:PTZ00421 120 --------------HLQGHTKKVGIVSFHPSAmNVLASAGADMVVNVWDVERGKAVEVI----KCHSDQITSLEWNLDgS 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462541457 2120 LLISCSSDGSVGLWDPESGQRLGQFLGHQSAVS--AVAAVEEHVV-----SVSRDGTLKVWDHQGVEltsIPAHSGPISH 2192
Cdd:PTZ00421 182 LLCTTSKDKKLNIIDPRDGTIVSSVEAHASAKSqrCLWAKRKDLIitlgcSKSQQRQIMLWDTRKMA---SPYSTVDLDQ 258
|
....*..
gi 2462541457 2193 CAAAMEP 2199
Cdd:PTZ00421 259 SSALFIP 265
|
|
| WD40 |
pfam00400 |
WD domain, G-beta repeat; |
2053-2089 |
6.13e-07 |
|
WD domain, G-beta repeat;
Pssm-ID: 459801 [Multi-domain] Cd Length: 39 Bit Score: 47.73 E-value: 6.13e-07
10 20 30
....*....|....*....|....*....|....*..
gi 2462541457 2053 CGTELRGHEGPVSCCSFSTDGGSLATGGRDRSLLCWD 2089
Cdd:pfam00400 3 LLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
|
|
| WD40 |
smart00320 |
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ... |
1756-1787 |
2.06e-04 |
|
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.
Pssm-ID: 197651 [Multi-domain] Cd Length: 40 Bit Score: 40.76 E-value: 2.06e-04
10 20 30
....*....|....*....|....*....|..
gi 2462541457 1756 KAHQYQITGCCLSPDCRLLATVCLGGCLKLWD 1787
Cdd:smart00320 9 KGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
|
|
| YcjX |
COG3106 |
Ras-like GTP-binding stress-induced protein YcjX, DUF463 family [Signal transduction ... |
1149-1199 |
1.01e-03 |
|
Ras-like GTP-binding stress-induced protein YcjX, DUF463 family [Signal transduction mechanisms];
Pssm-ID: 442340 Cd Length: 467 Bit Score: 44.41 E-value: 1.01e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|.
gi 2462541457 1149 LQDTVQRLMLPHGRLSlVTGQSGQGKTAFLASLVSALQApdGAKVASLVFF 1199
Cdd:COG3106 11 LADLANRLLDRHLRLA-VTGLSRSGKTAFITSLVNQLLH--GGSGARLPLF 58
|
|
| WD40 |
pfam00400 |
WD domain, G-beta repeat; |
1756-1787 |
6.22e-03 |
|
WD domain, G-beta repeat;
Pssm-ID: 459801 [Multi-domain] Cd Length: 39 Bit Score: 36.55 E-value: 6.22e-03
10 20 30
....*....|....*....|....*....|..
gi 2462541457 1756 KAHQYQITGCCLSPDCRLLATVCLGGCLKLWD 1787
Cdd:pfam00400 8 EGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| TROVE |
pfam05731 |
TROVE domain; This presumed domain is found in TEP1 and Ro60 proteins, that are RNA-binding ... |
226-676 |
9.27e-152 |
|
TROVE domain; This presumed domain is found in TEP1 and Ro60 proteins, that are RNA-binding components of Telomerase, Ro and Vault RNPs. This domain has been named TROVE, (after Telomerase, Ro and Vault). This domain is probably RNA-binding.
Pssm-ID: 461724 Cd Length: 361 Bit Score: 475.34 E-value: 9.27e-152
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462541457 226 TSGDSESHPEPTDHVLQEKKMALLSLLCST---LVSEVNMNNTS------DPTLAAIFEICREL-----ALLEPEFILKA 291
Cdd:pfam05731 1 VSNDSGGYPEPTDDVLQEKRFLLLGLLCGTyytLASEVTMDNAQaikiieDGTGASILETLRELsaagrAPKEPEFILKL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462541457 292 SLYARQQLNVRNVANNILAIAAFLPACRphlrryfcaivqLPSDWIQVAELYQSLAEGDKNKLVPLPACLRTAMTD---- 367
Cdd:pfam05731 81 ALYARQQLNIRDVANHVLAIAAVLPVCR------------LPTDLFEVAEYCEELAEGDEKKLTGWGRCLRRAMTDwyts 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462541457 368 KFAQFDEYQLAKYNPRKHRAKRHPRRPPRspgmePPFSHR---CFPRYIGFLREEQRKFEKAGDTVSEKKNPPRFTLKKL 444
Cdd:pfam05731 149 KFAEFLAYQLTKYNTRKHWSHKDPFRLPH-----PPKFSEtslELKGLFRYATKEQRKFEKAYGAVPEKKESKRLTLKKL 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462541457 445 VQRLHIHKPAQHVQALLGYRYpsnlqlfsrsRLpgpwdssragkrmklsrpeTWERELSLRGNKASVWEELIENgKLPFM 524
Cdd:pfam05731 224 VQRLHISEPAEHVQALIGKRY----------RL-------------------TWEREPSLRGNSAEVWEELIDS-KLPMM 273
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462541457 525 AMLRNLCNLLRVGISSRHHE-LILQRLQHAKSVIHSRQFPFRFLNAHdaidaleaqlrnqalpfpsnitlmrriltrnek 603
Cdd:pfam05731 274 AMLRNLCNLLRVGVSARHHEdLVLQRLQNPKSVIHSRQHPFRFLNAH--------------------------------- 320
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462541457 604 nrprrrflchlsrqqlrmamripVLYEQLKREKLRvhkaRQWKYDGEMlnryRQALETAVNLSVKhSLPLLPG 676
Cdd:pfam05731 321 -----------------------VVYEQGKGEKGK----LQWKPDPEI----SQALEAAFYLAVK-NLPPTPG 361
|
|
| DUF5920 |
pfam19334 |
Domain of unknown function (DUF5920); This domain is found in the Telomerase protein component ... |
687-889 |
6.87e-138 |
|
Domain of unknown function (DUF5920); This domain is found in the Telomerase protein component 1 (TEP1) and it contains an homology region to the telomerase associated protein from Tetrahymena p80. TEP1 is a component of the telomerase ribonucleoprotein complex and is thought to be responsible for catalysing the addition of new telomeres to chromosomes. TEP1 is also a component of the vault particle, a cytoplasmic ribonucleoprotein complex, in which it is required for vault RNA stability and its association with the vault particle. This domain is localized between the TROVE (pfam05731) and DUF4062 (pfam13271) domains.
Pssm-ID: 466045 Cd Length: 203 Bit Score: 428.81 E-value: 6.87e-138
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462541457 687 NADRLCPKSNPQGPPLNYALLLIGMMITRAEQVDVVLCGGDTLKTAVLKAEEGILKTAIKLQAQVQEFDENDGWSLNTFG 766
Cdd:pfam19334 1 NADRLCPKSNPQGPPLNYVLLLIGMMIARAEQVDLLLCGRGTLKTAVLKAEEGILKTAIKLQAQVQELEENDEWPLTTFG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462541457 767 KYLLSLAGQRVPVDRVILLGQSMDDGMINVAKQLYWQRVNSKCLFVGILLRRVQYLSTDLNPNDVTLSGCTDAILKFIAE 846
Cdd:pfam19334 81 KYLLSLAVQRVPVDRVILFGQTMNERLINVAKQLFWQHVNSKCLFVGVLLRKTQYISPDLNPNDVTLSGCTDGILKFIAE 160
|
170 180 190 200
....*....|....*....|....*....|....*....|...
gi 2462541457 847 HGASHLLEHVGQMDKIFKIPPPPGKTGVQSLRPLEEDTPSPLA 889
Cdd:pfam19334 161 RGASRLLEHVGQMDKIFKIPPPPGKTGVLSLRPLEEDTPSPLA 203
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
1849-2268 |
8.20e-70 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 241.35 E-value: 8.20e-70
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462541457 1849 AFNVPGGVVAVGRLDSMVELWAWREGARLAAFPAHHGFVAAALFLHAGCQLLTAGEDGKVQVWSGSLGRPRGHLGSLSlS 1928
Cdd:COG2319 1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHT-A 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462541457 1929 PALSVALSPDGDRVAVGYRADGIRIYKISSGSQGAQGQALDVAVSALAWlSP--KVLVSGAEDGSLQGWALKecSLQSLW 2006
Cdd:COG2319 80 AVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAF-SPdgKTLASGSADGTVRLWDLA--TGKLLR 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462541457 2007 LLSRFQKPVLGLATSQ--ELLASASEDFTVQLWprqlltrphKAEDFPCGTELRGHEGPVSCCSFSTDGGSLATGGRDRS 2084
Cdd:COG2319 157 TLTGHSGAVTSVAFSPdgKLLASGSDDGTVRLW---------DLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGT 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462541457 2085 LLCWDVRTPKtpvLIHSFPAcHRDWVTGCAWTKDN-LLISCSSDGSVGLWDPESGQRLGQFLGHQSAVSAVA--AVEEHV 2161
Cdd:COG2319 228 VRLWDLATGK---LLRTLTG-HSGSVRSVAFSPDGrLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAfsPDGKLL 303
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462541457 2162 VSVSRDGTLKVWD-HQGVELTSIPAHSGPISHCAAAmeprAAGQpgselLVVTVGLDGATRLWHPLLVCQTHTLLGHSGP 2240
Cdd:COG2319 304 ASGSDDGTVRLWDlATGKLLRTLTGHTGAVRSVAFS----PDGK-----TLASGSDDGTVRLWDLATGELLRTLTGHTGA 374
|
410 420
....*....|....*....|....*...
gi 2462541457 2241 VRAAAVSETSGLMLTASEDGSVRLWQVP 2268
Cdd:COG2319 375 VTSVAFSPDGRTLASGSADGTVRLWDLA 402
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
1683-2092 |
1.03e-60 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 215.16 E-value: 1.03e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462541457 1683 AFSTNGQRAAVGTANGTVYLLDLRTWQEEKSVVSGCDGISACLFLSDD-TLFLTAFDGLLELWDLQHGCRVLQTKAHQYQ 1761
Cdd:COG2319 1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGaRLAAGAGDLTLLLLDAAAGALLATLLGHTAA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462541457 1762 ITGCCLSPDCRLLATVCLGGCLKLWDTVRGQLAFQHT-YPKSLNCVAFHPEGQVIATGSWAGSISFFQVDGLKVTKDLGA 1840
Cdd:COG2319 81 VLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTgHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462541457 1841 PGASIRTLAFNVPGGVVAVGRLDSMVELWAWREGARLAAFPAHHGFVAAALFLHAGCQLLTAGEDGKVQVWSGSLGRPRG 1920
Cdd:COG2319 161 HSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLR 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462541457 1921 HLGSLSlSPALSVALSPDGDRVAVGYRADGIRIYKISSGSQGAQGQALDVAVSALAWlSP--KVLVSGAEDGSLQGWALK 1998
Cdd:COG2319 241 TLTGHS-GSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAF-SPdgKLLASGSDDGTVRLWDLA 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462541457 1999 ecSLQSLWLLSRFQKPVLGLATSQ--ELLASASEDFTVQLWprqlltrphKAEDFPCGTELRGHEGPVSCCSFSTDGGSL 2076
Cdd:COG2319 319 --TGKLLRTLTGHTGAVRSVAFSPdgKTLASGSDDGTVRLW---------DLATGELLRTLTGHTGAVTSVAFSPDGRTL 387
|
410
....*....|....*.
gi 2462541457 2077 ATGGRDRSLLCWDVRT 2092
Cdd:COG2319 388 ASGSADGTVRLWDLAT 403
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
1725-2137 |
2.37e-60 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 214.00 E-value: 2.37e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462541457 1725 LFLSDDTLFLTAFDGLLELWDLQHGCRVLQTKAHQYQITGCCLSPDCRLLATVCLGGCLKLWDTVRGQLAFQHTYPKS-L 1803
Cdd:COG2319 2 LSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAaV 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462541457 1804 NCVAFHPEGQVIATGSWAGSISFFQVDGLKVTKDLGAPGASIRTLAFNVPGGVVAVGRLDSMVELWAWREGARLAAFPAH 1883
Cdd:COG2319 82 LSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGH 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462541457 1884 HGFVAAALFLHAGCQLLTAGEDGKVQVWSGSLGRP----RGHLGSLSlspalSVALSPDGDRVAVGYRADGIRIYKISSG 1959
Cdd:COG2319 162 SGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLlrtlTGHTGAVR-----SVAFSPDGKLLASGSADGTVRLWDLATG 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462541457 1960 SQGAQGQALDVAVSALAWlSP--KVLVSGAEDGSLQGWALKecSLQSLWLLSRFQKPVLGLATSQ--ELLASASEDFTVQ 2035
Cdd:COG2319 237 KLLRTLTGHSGSVRSVAF-SPdgRLLASGSADGTVRLWDLA--TGELLRTLTGHSGGVNSVAFSPdgKLLASGSDDGTVR 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462541457 2036 LWprqlltrphKAEDFPCGTELRGHEGPVSCCSFSTDGGSLATGGRDRSLLCWDVRTPKtpvLIHSFPAcHRDWVTGCAW 2115
Cdd:COG2319 314 LW---------DLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGE---LLRTLTG-HTGAVTSVAF 380
|
410 420
....*....|....*....|...
gi 2462541457 2116 TKD-NLLISCSSDGSVGLWDPES 2137
Cdd:COG2319 381 SPDgRTLASGSADGTVRLWDLAT 403
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
1972-2308 |
1.70e-55 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 196.02 E-value: 1.70e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462541457 1972 VSALAWL-SPKVLVSGAEDGSLQGWalkecSLQSLWLLSRFQ---KPVLGLATS--QELLASASEDFTVQLWPrqlltrp 2045
Cdd:cd00200 12 VTCVAFSpDGKLLATGSGDGTIKVW-----DLETGELLRTLKghtGPVRDVAASadGTYLASGSSDKTIRLWD------- 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462541457 2046 hkAEDFPCGTELRGHEGPVSCCSFSTDGGSLATGGRDRSLLCWDVRTPKtpvLIHSFPaCHRDWVTGCAWTKDNLLISCS 2125
Cdd:cd00200 80 --LETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGK---CLTTLR-GHTDWVNSVAFSPDGTFVASS 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462541457 2126 S-DGSVGLWDPESGQRLGQFLGHQSAVSAVAAV--EEHVVSVSRDGTLKVWDHQgveltsipahsgpishcaaamepraA 2202
Cdd:cd00200 154 SqDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSpdGEKLLSSSSDGTIKLWDLS-------------------------T 208
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462541457 2203 GQpgsellvvtvgldgatrlwhpllvcQTHTLLGHSGPVRAAAVSETSGLMLTASEDGSVRLWQVPKEADDTCIPRSSAA 2282
Cdd:cd00200 209 GK-------------------------CLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNS 263
|
330 340
....*....|....*....|....*.
gi 2462541457 2283 VTAVAWAPDGSMAVSGNQAGELILWQ 2308
Cdd:cd00200 264 VTSLAWSPDGKRLASGSADGTIRIWD 289
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
1975-2391 |
2.94e-53 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 193.59 E-value: 2.94e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462541457 1975 LAWLSPKVLVSGAEDGSLQGWALKECSLQSLWLLSRFQKPVLGLATSQELLASASEDFTVQLWPRQLLTRPHkaedfpcg 2054
Cdd:COG2319 1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLA-------- 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462541457 2055 tELRGHEGPVSCCSFSTDGGSLATGGRDRSLLCWDVRTPKTPVLIHSfpacHRDWVTGCAWTKD-NLLISCSSDGSVGLW 2133
Cdd:COG2319 73 -TLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTG----HTGAVRSVAFSPDgKTLASGSADGTVRLW 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462541457 2134 DPESGQRLGQFLGHQSAVSAVA--AVEEHVVSVSRDGTLKVWD-HQGVELTSIPAHSGPISHCAAAmepraagqPGSELL 2210
Cdd:COG2319 148 DLATGKLLRTLTGHSGAVTSVAfsPDGKLLASGSDDGTVRLWDlATGKLLRTLTGHTGAVRSVAFS--------PDGKLL 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462541457 2211 VvTVGLDGATRLWHPLLVCQTHTLLGHSGPVRAAAVSETSGLMLTASEDGSVRLWQVPKEADDTCIPRSSAAVTAVAWAP 2290
Cdd:COG2319 220 A-SGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSP 298
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462541457 2291 DGSMAVSGNQAGELILWQEAKAVATAQAPGHIG---ALIWSSA-HTFFVLSADEKISEWQvkLRKGSAPGNLSLHLNRIl 2366
Cdd:COG2319 299 DGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGavrSVAFSPDgKTLASGSDDGTVRLWD--LATGELLRTLTGHTGAV- 375
|
410 420
....*....|....*....|....*
gi 2462541457 2367 qedlgvlTSLDWAPDGHFLILAKAD 2391
Cdd:COG2319 376 -------TSVAFSPDGRTLASGSAD 393
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
2056-2346 |
5.72e-53 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 188.70 E-value: 5.72e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462541457 2056 ELRGHEGPVSCCSFSTDGGSLATGGRDRSLLCWDVrtpKTPVLIHSFPAcHRDWVTGCAWTKD-NLLISCSSDGSVGLWD 2134
Cdd:cd00200 4 TLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDL---ETGELLRTLKG-HTGPVRDVAASADgTYLASGSSDKTIRLWD 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462541457 2135 PESGQRLGQFLGHQSAVSAVAAVEEH--VVSVSRDGTLKVWD-HQGVELTSIPAHSGPISHCAAamepraagqPGSELLV 2211
Cdd:cd00200 80 LETGECVRTLTGHTSYVSSVAFSPDGriLSSSSRDKTIKVWDvETGKCLTTLRGHTDWVNSVAF---------SPDGTFV 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462541457 2212 VTVGLDGATRLWHP-LLVCQtHTLLGHSGPVRAAAVSETSGLMLTASEDGSVRLWQVPKEADDTCIPRSSAAVTAVAWAP 2290
Cdd:cd00200 151 ASSSQDGTIKLWDLrTGKCV-ATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSP 229
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462541457 2291 DGSMAVSGNQAGELILWQEAKAVATAQAPGH---IGALIWS-SAHTFFVLSADEKISEWQ 2346
Cdd:cd00200 230 DGYLLASGSEDGTIRVWDLRTGECVQTLSGHtnsVTSLAWSpDGKRLASGSADGTIRIWD 289
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
1680-1958 |
1.84e-48 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 179.34 E-value: 1.84e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462541457 1680 TAVAFSTNGQRAAVGTANGTVYLLDLRTWQEEKSVVSGCDGISACLFLSDDTLFLTA-FDGLLELWDLQHGCRVLQTKAH 1758
Cdd:COG2319 124 RSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGsDDGTVRLWDLATGKLLRTLTGH 203
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462541457 1759 QYQITGCCLSPDCRLLATVCLGGCLKLWDTVRGQ-LAFQHTYPKSLNCVAFHPEGQVIATGSWAGSISFFQVDGLKVTKD 1837
Cdd:COG2319 204 TGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKlLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRT 283
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462541457 1838 LGAPGASIRTLAFNVPGGVVAVGRLDSMVELWAWREGARLAAFPAHHGFVAAALFLHAGCQLLTAGEDGKVQVWSGSLGR 1917
Cdd:COG2319 284 LTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGE 363
|
250 260 270 280
....*....|....*....|....*....|....*....|....*
gi 2462541457 1918 P----RGHLGslslsPALSVALSPDGDRVAVGYRADGIRIYKISS 1958
Cdd:COG2319 364 LlrtlTGHTG-----AVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
1799-2174 |
5.08e-44 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 162.89 E-value: 5.08e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462541457 1799 YPKSLNCVAFHPEGQVIATGSWagsisffqvdglkvtkdlgapgasirtlafnvpggvvavgrlDSMVELWAWREGARLA 1878
Cdd:cd00200 8 HTGGVTCVAFSPDGKLLATGSG------------------------------------------DGTIKVWDLETGELLR 45
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462541457 1879 AFPAHHGFVAAALFLHAGCQLLTAGEDGKVQVWSGSLGRP----RGHLGSLSlspalSVALSPDGdRVAVGYRADG-IRI 1953
Cdd:cd00200 46 TLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECvrtlTGHTSYVS-----SVAFSPDG-RILSSSSRDKtIKV 119
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462541457 1954 YKISSGS-----QGAQGQALDVAVSalawlspkvlvsgaedgslqgwalkecslqslwllsrfqkpvlglaTSQELLASA 2028
Cdd:cd00200 120 WDVETGKclttlRGHTDWVNSVAFS----------------------------------------------PDGTFVASS 153
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462541457 2029 SEDFTVQLWprqlltrphKAEDFPCGTELRGHEGPVSCCSFSTDGGSLATGGRDRSLLCWDVRTPKtpvLIHSFPAcHRD 2108
Cdd:cd00200 154 SQDGTIKLW---------DLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGK---CLGTLRG-HEN 220
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2462541457 2109 WVTGCAWTKDN-LLISCSSDGSVGLWDPESGQRLGQFLGHQSAVSAVAAVEE--HVVSVSRDGTLKVWD 2174
Cdd:cd00200 221 GVNSVAFSPDGyLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDgkRLASGSADGTIRIWD 289
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
1680-1955 |
1.96e-36 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 140.93 E-value: 1.96e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462541457 1680 TAVAFSTNGQRAAVGTANGTVYLLDLRTWQEEKSVVSGCDGISACLFLSDDTLFLTA-FDGLLELWDLQHGCRVLQTKAH 1758
Cdd:cd00200 13 TCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGsSDKTIRLWDLETGECVRTLTGH 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462541457 1759 QYQITGCCLSPDCRLLATVCLGGCLKLWDTVRGQLAF---QHTypKSLNCVAFHPEGQVIATGSWAGSISFFQVDGLKVT 1835
Cdd:cd00200 93 TSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTtlrGHT--DWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCV 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462541457 1836 KDLGAPGASIRTLAFNVPGGVVAVGRLDSMVELWAWREGARLAAFPAHHGFVAAALFLHAGCQLLTAGEDGKVQVWSGSL 1915
Cdd:cd00200 171 ATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRT 250
|
250 260 270 280
....*....|....*....|....*....|....*....|.
gi 2462541457 1916 GRPRGHLGSLSlSPALSVALSPDGDRVAVGYrADG-IRIYK 1955
Cdd:cd00200 251 GECVQTLSGHT-NSVTSLAWSPDGKRLASGS-ADGtIRIWD 289
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
1719-1996 |
1.98e-36 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 140.93 E-value: 1.98e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462541457 1719 DGISACLFLSDDTLFLTAF-DGLLELWDLQHGCRVLQTKAHQYQITGCCLSPDCRLLATVCLGGCLKLWDTVRGQLA--- 1794
Cdd:cd00200 10 GGVTCVAFSPDGKLLATGSgDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVrtl 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462541457 1795 FQHTypKSLNCVAFHPEGQVIATGSWAGSISFFQVDGLKVTKDLGAPGASIRTLAFNVPGGVVAVGRLDSMVELWAWREG 1874
Cdd:cd00200 90 TGHT--SYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTG 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462541457 1875 ARLAAFPAHHGFVAAALFLHAGCQLLTAGEDGKVQVWSGSLGRP----RGHLGSLslspaLSVALSPDGDRVAVGYRADG 1950
Cdd:cd00200 168 KCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKClgtlRGHENGV-----NSVAFSPDGYLLASGSEDGT 242
|
250 260 270 280
....*....|....*....|....*....|....*....|....*...
gi 2462541457 1951 IRIYKISSGSQGAQGQALDVAVSALAWlSP--KVLVSGAEDGSLQGWA 1996
Cdd:cd00200 243 IRVWDLRTGECVQTLSGHTNSVTSLAW-SPdgKRLASGSADGTIRIWD 289
|
|
| NACHT |
pfam05729 |
NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in ... |
1162-1337 |
2.19e-32 |
|
NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in MHC transcription activation. This family is closely related to pfam00931.
Pssm-ID: 428606 [Multi-domain] Cd Length: 166 Bit Score: 124.72 E-value: 2.19e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462541457 1162 RLSLVTGQSGQGKTAFLASLVSALQAPDGAKVASLVFFHFSGARPDQGLAltllRRLCTYLRGQLKEPGALPSTYRSLVW 1241
Cdd:pfam05729 1 RTVILQGEAGSGKTTLLQKLALLWAQGKLPQGFDFVFFLPCRELSRSGNA----RSLADLLFSQWPEPAAPVSEVWAVIL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462541457 1242 ELQQRLLpksaeslhpgqtqvLIIDGADRLVDQNGQ---------LISDWIPKKLPRCVHLVLSVSSDAG--LGETLEQS 1310
Cdd:pfam05729 77 ELPERLL--------------LILDGLDELVSDLGQldgpcpvltLLSSLLRKKLLPGASLLLTVRPDALrdLRRGLEEP 142
|
170 180
....*....|....*....|....*..
gi 2462541457 1311 QgahVLALGPLEASARARLVREELALY 1337
Cdd:pfam05729 143 R---YLEVRGFSESDRKQYVRKYFSDE 166
|
|
| DUF4062 |
pfam13271 |
Domain of unknown function (DUF4062); This presumed domain is functionally uncharacterized. ... |
900-1008 |
1.04e-15 |
|
Domain of unknown function (DUF4062); This presumed domain is functionally uncharacterized. This domain family is found in bacteria, archaea and eukaryotes, and is approximately 80 amino acids in length. There is a conserved SST sequence motif.
Pssm-ID: 463823 Cd Length: 78 Bit Score: 74.16 E-value: 1.04e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462541457 900 RLFISSTFRDMHGERDLLLRSVlpalqaRAAPHrislhgidLRWGVTEEETRRNRQLEVCLGEVENAQLFVGILGSRYGY 979
Cdd:pfam13271 1 KVFISSTFYDLKEEREALIEAL------LELGH--------IPVGMEEFPASDESPLDVCLREVDECDIYILILGGRYGS 66
|
90 100
....*....|....*....|....*....
gi 2462541457 980 IPpsynlpdhphfhwaqqyPSGRSVTEME 1008
Cdd:pfam13271 67 ID-----------------PDGISYTELE 78
|
|
| TEP1_N |
pfam05386 |
TEP1 N-terminal domain; This short sequence region is found in four copies at the N-terminus ... |
1-29 |
8.83e-15 |
|
TEP1 N-terminal domain; This short sequence region is found in four copies at the N-terminus of the TEP1 telomerase component. The functional significance of the region is uncertain. However the conservation of two histidines and a cysteine suggests it is a potential zinc binding domain.
Pssm-ID: 428450 Cd Length: 29 Bit Score: 69.74 E-value: 8.83e-15
10 20
....*....|....*....|....*....
gi 2462541457 1 MEKLHGHVSAHPDILSLENRCLAMLPDLQ 29
Cdd:pfam05386 1 MEKPHGHVSAHPDILSLENRCLATLPDLK 29
|
|
| TEP1_N |
pfam05386 |
TEP1 N-terminal domain; This short sequence region is found in four copies at the N-terminus ... |
91-119 |
3.67e-14 |
|
TEP1 N-terminal domain; This short sequence region is found in four copies at the N-terminus of the TEP1 telomerase component. The functional significance of the region is uncertain. However the conservation of two histidines and a cysteine suggests it is a potential zinc binding domain.
Pssm-ID: 428450 Cd Length: 29 Bit Score: 68.20 E-value: 3.67e-14
10 20
....*....|....*....|....*....
gi 2462541457 91 MEKPHGHVSAHPDILSLENRCLATLSSLK 119
Cdd:pfam05386 1 MEKPHGHVSAHPDILSLENRCLATLPDLK 29
|
|
| TEP1_N |
pfam05386 |
TEP1 N-terminal domain; This short sequence region is found in four copies at the N-terminus ... |
61-89 |
1.51e-13 |
|
TEP1 N-terminal domain; This short sequence region is found in four copies at the N-terminus of the TEP1 telomerase component. The functional significance of the region is uncertain. However the conservation of two histidines and a cysteine suggests it is a potential zinc binding domain.
Pssm-ID: 428450 Cd Length: 29 Bit Score: 66.27 E-value: 1.51e-13
10 20
....*....|....*....|....*....
gi 2462541457 61 MEKPHGYVSAHPDILSLENQCLATLSDLK 89
Cdd:pfam05386 1 MEKPHGHVSAHPDILSLENRCLATLPDLK 29
|
|
| TEP1_N |
pfam05386 |
TEP1 N-terminal domain; This short sequence region is found in four copies at the N-terminus ... |
31-59 |
6.92e-12 |
|
TEP1 N-terminal domain; This short sequence region is found in four copies at the N-terminus of the TEP1 telomerase component. The functional significance of the region is uncertain. However the conservation of two histidines and a cysteine suggests it is a potential zinc binding domain.
Pssm-ID: 428450 Cd Length: 29 Bit Score: 61.65 E-value: 6.92e-12
10 20
....*....|....*....|....*....
gi 2462541457 31 LEKLHQHVSTHSDILSLKNQCLATLPDLK 59
Cdd:pfam05386 1 MEKPHGHVSAHPDILSLENRCLATLPDLK 29
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
2231-2391 |
2.55e-11 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 66.97 E-value: 2.55e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462541457 2231 THTLLGHSGPVRAAAVSETSGLMLTASEDGSVRLWQVPKE-------------------ADDTCIPRSS----------- 2280
Cdd:cd00200 2 RRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGellrtlkghtgpvrdvaasADGTYLASGSsdktirlwdle 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462541457 2281 ------------AAVTAVAWAPDGSMAVSGNQAGELILWQEAKAVATAQAPGHIG---ALIWSSAHTfFVLSA--DEKIS 2343
Cdd:cd00200 82 tgecvrtltghtSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDwvnSVAFSPDGT-FVASSsqDGTIK 160
|
170 180 190 200
....*....|....*....|....*....|....*....|....*...
gi 2462541457 2344 EWQvkLRKGSAPGNLSLHLNRIlqedlgvlTSLDWAPDGHFLILAKAD 2391
Cdd:cd00200 161 LWD--LRTGKCVATLTGHTGEV--------NSVAFSPDGEKLLSSSSD 198
|
|
| WD40 |
smart00320 |
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ... |
2050-2089 |
1.79e-07 |
|
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.
Pssm-ID: 197651 [Multi-domain] Cd Length: 40 Bit Score: 49.23 E-value: 1.79e-07
10 20 30 40
....*....|....*....|....*....|....*....|
gi 2462541457 2050 DFPCGTELRGHEGPVSCCSFSTDGGSLATGGRDRSLLCWD 2089
Cdd:smart00320 1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
|
|
| PTZ00421 |
PTZ00421 |
coronin; Provisional |
1962-2199 |
4.25e-07 |
|
coronin; Provisional
Pssm-ID: 173611 [Multi-domain] Cd Length: 493 Bit Score: 55.28 E-value: 4.25e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462541457 1962 GAQGQALDVAVSALawlSPKVLVSGAEDGSLQGWALKECSLQSlwllsrfqkpvlglATSQELLasasedftvqlwprql 2041
Cdd:PTZ00421 73 GQEGPIIDVAFNPF---DPQKLFTASEDGTIMGWGIPEEGLTQ--------------NISDPIV---------------- 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462541457 2042 ltrphkaedfpcgtELRGHEGPVSCCSFSTDG-GSLATGGRDRSLLCWDVRTPKTPVLIhsfpACHRDWVTGCAWTKD-N 2119
Cdd:PTZ00421 120 --------------HLQGHTKKVGIVSFHPSAmNVLASAGADMVVNVWDVERGKAVEVI----KCHSDQITSLEWNLDgS 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462541457 2120 LLISCSSDGSVGLWDPESGQRLGQFLGHQSAVS--AVAAVEEHVV-----SVSRDGTLKVWDHQGVEltsIPAHSGPISH 2192
Cdd:PTZ00421 182 LLCTTSKDKKLNIIDPRDGTIVSSVEAHASAKSqrCLWAKRKDLIitlgcSKSQQRQIMLWDTRKMA---SPYSTVDLDQ 258
|
....*..
gi 2462541457 2193 CAAAMEP 2199
Cdd:PTZ00421 259 SSALFIP 265
|
|
| WD40 |
pfam00400 |
WD domain, G-beta repeat; |
2053-2089 |
6.13e-07 |
|
WD domain, G-beta repeat;
Pssm-ID: 459801 [Multi-domain] Cd Length: 39 Bit Score: 47.73 E-value: 6.13e-07
10 20 30
....*....|....*....|....*....|....*..
gi 2462541457 2053 CGTELRGHEGPVSCCSFSTDGGSLATGGRDRSLLCWD 2089
Cdd:pfam00400 3 LLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
|
|
| WD40 |
smart00320 |
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ... |
2232-2265 |
4.25e-06 |
|
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.
Pssm-ID: 197651 [Multi-domain] Cd Length: 40 Bit Score: 45.38 E-value: 4.25e-06
10 20 30
....*....|....*....|....*....|....
gi 2462541457 2232 HTLLGHSGPVRAAAVSETSGLMLTASEDGSVRLW 2265
Cdd:smart00320 6 KTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
|
|
| WD40 |
smart00320 |
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ... |
2095-2134 |
6.55e-06 |
|
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.
Pssm-ID: 197651 [Multi-domain] Cd Length: 40 Bit Score: 45.00 E-value: 6.55e-06
10 20 30 40
....*....|....*....|....*....|....*....|.
gi 2462541457 2095 TPVLIHSFPAcHRDWVTGCAWTKD-NLLISCSSDGSVGLWD 2134
Cdd:smart00320 1 SGELLKTLKG-HTGPVTSVAFSPDgKYLASGSDDGTIKLWD 40
|
|
| PLN00181 |
PLN00181 |
protein SPA1-RELATED; Provisional |
1972-2147 |
8.48e-06 |
|
protein SPA1-RELATED; Provisional
Pssm-ID: 177776 [Multi-domain] Cd Length: 793 Bit Score: 51.24 E-value: 8.48e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462541457 1972 VSALAWLS--PKVLVSGAEDGSLQGWALKECSLQSLwlLSRFQKPVLGLATSQE---LLASASEDFTVQLWPRQlltrph 2046
Cdd:PLN00181 535 LSGICWNSyiKSQVASSNFEGVVQVWDVARSQLVTE--MKEHEKRVWSIDYSSAdptLLASGSDDGSVKLWSIN------ 606
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462541457 2047 kaEDFPCGTelRGHEGPVSCCSFSTDGG-SLATGGRDRSLLCWDVRTPKTPVlihsfpaC----HRDWVTGCAWTKDNLL 2121
Cdd:PLN00181 607 --QGVSIGT--IKTKANICCVQFPSESGrSLAFGSADHKVYYYDLRNPKLPL-------CtmigHSKTVSYVRFVDSSTL 675
|
170 180 190
....*....|....*....|....*....|..
gi 2462541457 2122 ISCSSDGSVGLWD---PESG---QRLGQFLGH 2147
Cdd:PLN00181 676 VSSSTDNTLKLWDlsmSISGineTPLHSFMGH 707
|
|
| WD40 |
pfam00400 |
WD domain, G-beta repeat; |
2230-2265 |
1.17e-05 |
|
WD domain, G-beta repeat;
Pssm-ID: 459801 [Multi-domain] Cd Length: 39 Bit Score: 44.26 E-value: 1.17e-05
10 20 30
....*....|....*....|....*....|....*.
gi 2462541457 2230 QTHTLLGHSGPVRAAAVSETSGLMLTASEDGSVRLW 2265
Cdd:pfam00400 3 LLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
|
|
| WD40 |
pfam00400 |
WD domain, G-beta repeat; |
2098-2134 |
1.45e-04 |
|
WD domain, G-beta repeat;
Pssm-ID: 459801 [Multi-domain] Cd Length: 39 Bit Score: 41.18 E-value: 1.45e-04
10 20 30
....*....|....*....|....*....|....*...
gi 2462541457 2098 LIHSFPAcHRDWVTGCAWTKD-NLLISCSSDGSVGLWD 2134
Cdd:pfam00400 3 LLKTLEG-HTGSVTSLAFSPDgKLLASGSDDGTVKVWD 39
|
|
| WD40 |
smart00320 |
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ... |
1756-1787 |
2.06e-04 |
|
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.
Pssm-ID: 197651 [Multi-domain] Cd Length: 40 Bit Score: 40.76 E-value: 2.06e-04
10 20 30
....*....|....*....|....*....|..
gi 2462541457 1756 KAHQYQITGCCLSPDCRLLATVCLGGCLKLWD 1787
Cdd:smart00320 9 KGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
|
|
| WD40 |
smart00320 |
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ... |
2137-2174 |
4.47e-04 |
|
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.
Pssm-ID: 197651 [Multi-domain] Cd Length: 40 Bit Score: 39.99 E-value: 4.47e-04
10 20 30 40
....*....|....*....|....*....|....*....|
gi 2462541457 2137 SGQRLGQFLGHQSAVSAVA--AVEEHVVSVSRDGTLKVWD 2174
Cdd:smart00320 1 SGELLKTLKGHTGPVTSVAfsPDGKYLASGSDDGTIKLWD 40
|
|
| AAA_16 |
pfam13191 |
AAA ATPase domain; This family of domains contain a P-loop motif that is characteriztic of the ... |
1147-1280 |
6.90e-04 |
|
AAA ATPase domain; This family of domains contain a P-loop motif that is characteriztic of the AAA superfamily.
Pssm-ID: 433025 [Multi-domain] Cd Length: 167 Bit Score: 42.88 E-value: 6.90e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462541457 1147 RLLQDTVQRLMLPHGRLSLVTGQSGQGKTAFLASLVSALqAPDGAKVASLVFFHFSGARP--DQGLALTLLRRLCT---- 1220
Cdd:pfam13191 10 EQLLDALDRVRSGRPPSVLLTGEAGTGKTTLLRELLRAL-ERDGGYFLRGKCDENLPYSPllEALTREGLLRQLLDeles 88
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2462541457 1221 --------YLRGQLKEPGALPSTYRSLVWELQQRLLPKSAESLHPgqtQVLIIDGADRLVDQNGQLIS 1280
Cdd:pfam13191 89 slleawraALLEALAPVPELPGDLAERLLDLLLRLLDLLARGERP---LVLVLDDLQWADEASLQLLA 153
|
|
| WD40 |
pfam00400 |
WD domain, G-beta repeat; |
2138-2174 |
8.18e-04 |
|
WD domain, G-beta repeat;
Pssm-ID: 459801 [Multi-domain] Cd Length: 39 Bit Score: 39.25 E-value: 8.18e-04
10 20 30
....*....|....*....|....*....|....*....
gi 2462541457 2138 GQRLGQFLGHQSAVSAVA--AVEEHVVSVSRDGTLKVWD 2174
Cdd:pfam00400 1 GKLLKTLEGHTGSVTSLAfsPDGKLLASGSDDGTVKVWD 39
|
|
| YcjX |
COG3106 |
Ras-like GTP-binding stress-induced protein YcjX, DUF463 family [Signal transduction ... |
1149-1199 |
1.01e-03 |
|
Ras-like GTP-binding stress-induced protein YcjX, DUF463 family [Signal transduction mechanisms];
Pssm-ID: 442340 Cd Length: 467 Bit Score: 44.41 E-value: 1.01e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|.
gi 2462541457 1149 LQDTVQRLMLPHGRLSlVTGQSGQGKTAFLASLVSALQApdGAKVASLVFF 1199
Cdd:COG3106 11 LADLANRLLDRHLRLA-VTGLSRSGKTAFITSLVNQLLH--GGSGARLPLF 58
|
|
| AAA_22 |
pfam13401 |
AAA domain; |
1160-1271 |
1.81e-03 |
|
AAA domain;
Pssm-ID: 379165 [Multi-domain] Cd Length: 129 Bit Score: 40.79 E-value: 1.81e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462541457 1160 HGRLSLVTGQSGQGKTAFLASLVSALQAPDgakvASLVFFHFSGarpdqglaLTLLRRLCTYLRGQLKEPGALPSTYRSL 1239
Cdd:pfam13401 4 GAGILVLTGESGTGKTTLLRRLLEQLPEVR----DSVVFVDLPS--------GTSPKDLLRALLRALGLPLSGRLSKEEL 71
|
90 100 110
....*....|....*....|....*....|..
gi 2462541457 1240 VWELQQRLlpksaesLHPGQTQVLIIDGADRL 1271
Cdd:pfam13401 72 LAALQQLL-------LALAVAVVLIIDEAQHL 96
|
|
| WD40 |
smart00320 |
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ... |
1874-1912 |
6.08e-03 |
|
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.
Pssm-ID: 197651 [Multi-domain] Cd Length: 40 Bit Score: 36.52 E-value: 6.08e-03
10 20 30
....*....|....*....|....*....|....*....
gi 2462541457 1874 GARLAAFPAHHGFVAAALFLHAGCQLLTAGEDGKVQVWS 1912
Cdd:smart00320 2 GELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
|
|
| WD40 |
pfam00400 |
WD domain, G-beta repeat; |
1756-1787 |
6.22e-03 |
|
WD domain, G-beta repeat;
Pssm-ID: 459801 [Multi-domain] Cd Length: 39 Bit Score: 36.55 E-value: 6.22e-03
10 20 30
....*....|....*....|....*....|..
gi 2462541457 1756 KAHQYQITGCCLSPDCRLLATVCLGGCLKLWD 1787
Cdd:pfam00400 8 EGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
|
|
| ExeA |
COG3267 |
Type II secretory pathway ATPase component GspA/ExeA/MshM [Intracellular trafficking, ... |
1160-1271 |
9.35e-03 |
|
Type II secretory pathway ATPase component GspA/ExeA/MshM [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];
Pssm-ID: 442498 [Multi-domain] Cd Length: 261 Bit Score: 40.54 E-value: 9.35e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462541457 1160 HGRLSLVTGQSGQGKTAFLASLVSALqaPDGAKVASLVFFHFSgarpdqglALTLLRRLCTYLRGQLKepgalPSTYRSL 1239
Cdd:COG3267 42 GGGFVVLTGEVGTGKTTLLRRLLERL--PDDVKVAYIPNPQLS--------PAELLRAIADELGLEPK-----GASKADL 106
|
90 100 110
....*....|....*....|....*....|..
gi 2462541457 1240 VWELQQRLLPKSAESLHPgqtqVLIIDGADRL 1271
Cdd:COG3267 107 LRQLQEFLLELAAAGRRV----VLIIDEAQNL 134
|
|
| |
