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Conserved domains on  [gi|2462548307|ref|XP_054235959|]
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origin recognition complex subunit 6 isoform X1 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Orc6_mid super family cl21687
Middle domain of the origin recognition complex subunit 6; Orc6 is a subunit of the origin ...
 6-94 1.35e-16

Middle domain of the origin recognition complex subunit 6; Orc6 is a subunit of the origin recognition complex in eukaryotes, and it may be involved in binding to DNA. This model describes the central or middle domain of Orc6, whose structure resembles that of TFIIB, a DNA-binding transcription factor. Orc6 appears to form distinct complexes with DNA, and a putative DNA-binding site has been identified.


The actual alignment was detected with superfamily member pfam05460:

Pssm-ID: 389868 [Multi-domain]  Cd Length: 288  Bit Score: 75.77  E-value: 1.35e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462548307   6 IGRLAPRLGLAEPD-MLRKAEEYLRLSRVKCVGLSARTtETSSAVMCLDLAASWMKCPLDRAYLIKLSGLNKETYQSCLK 84
Cdd:pfam05460   1 LSDLLPTLGLGYPKkLLSKASELYRLSLVKKVMLKNNE-EIARCHICAELAAEKLSIKLDLPYAVKLIPLPPKAYAKLLD 79

                          90
                  ....*....|
gi 2462548307  85 SFECLLGLNS 94
Cdd:pfam05460  80 TFRNSLGNQS 89
Orc6_mid super family cl21687
Middle domain of the origin recognition complex subunit 6; Orc6 is a subunit of the origin ...
 94-150 1.12e-13

Middle domain of the origin recognition complex subunit 6; Orc6 is a subunit of the origin recognition complex in eukaryotes, and it may be involved in binding to DNA. This model describes the central or middle domain of Orc6, whose structure resembles that of TFIIB, a DNA-binding transcription factor. Orc6 appears to form distinct complexes with DNA, and a putative DNA-binding site has been identified.


The actual alignment was detected with superfamily member cd11583:

Pssm-ID: 389868  Cd Length: 94  Bit Score: 63.85  E-value: 1.12e-13
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2462548307  94 SNIGIRDLAVQFSCIEAVNMASKILKSYESSLPQT-QQVDLDLSRPLFTSAALLSACK 150
Cdd:cd11583     1 SRLSVRDLAVQFGCKEAIEEAEKLLNRYKLPFLASeQRRVADFSLPQFTAAAFYLACK 58
 
Name Accession Description Interval E-value
ORC6 pfam05460
Origin recognition complex subunit 6 (ORC6); This family consists of several eukaryotic origin ...
 6-94 1.35e-16

Origin recognition complex subunit 6 (ORC6); This family consists of several eukaryotic origin recognition complex subunit 6 (ORC6) proteins. Despite differences in their structure and sequences among eukaryotic replicators, ORC is a conserved feature of replication initiation in all eukaryotes. ORC-related genes have been identified in organizms ranging from S. pombe to plants to humans. All DNA replication initiation is driven by a single conserved eukaryotic initiator complex termed he origin recognition complex (ORC). The ORC is a six protein complex. The function of ORC is reviewed in.


Pssm-ID: 368452 [Multi-domain]  Cd Length: 288  Bit Score: 75.77  E-value: 1.35e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462548307   6 IGRLAPRLGLAEPD-MLRKAEEYLRLSRVKCVGLSARTtETSSAVMCLDLAASWMKCPLDRAYLIKLSGLNKETYQSCLK 84
Cdd:pfam05460   1 LSDLLPTLGLGYPKkLLSKASELYRLSLVKKVMLKNNE-EIARCHICAELAAEKLSIKLDLPYAVKLIPLPPKAYAKLLD 79

                          90
                  ....*....|
gi 2462548307  85 SFECLLGLNS 94
Cdd:pfam05460  80 TFRNSLGNQS 89
Orc6_mid cd11583
Middle domain of the origin recognition complex subunit 6; Orc6 is a subunit of the origin ...
 94-150 1.12e-13

Middle domain of the origin recognition complex subunit 6; Orc6 is a subunit of the origin recognition complex in eukaryotes, and it may be involved in binding to DNA. This model describes the central or middle domain of Orc6, whose structure resembles that of TFIIB, a DNA-binding transcription factor. Orc6 appears to form distinct complexes with DNA, and a putative DNA-binding site has been identified.


Pssm-ID: 211425  Cd Length: 94  Bit Score: 63.85  E-value: 1.12e-13
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2462548307  94 SNIGIRDLAVQFSCIEAVNMASKILKSYESSLPQT-QQVDLDLSRPLFTSAALLSACK 150
Cdd:cd11583     1 SRLSVRDLAVQFGCKEAIEEAEKLLNRYKLPFLASeQRRVADFSLPQFTAAAFYLACK 58
 
Name Accession Description Interval E-value
ORC6 pfam05460
Origin recognition complex subunit 6 (ORC6); This family consists of several eukaryotic origin ...
 6-94 1.35e-16

Origin recognition complex subunit 6 (ORC6); This family consists of several eukaryotic origin recognition complex subunit 6 (ORC6) proteins. Despite differences in their structure and sequences among eukaryotic replicators, ORC is a conserved feature of replication initiation in all eukaryotes. ORC-related genes have been identified in organizms ranging from S. pombe to plants to humans. All DNA replication initiation is driven by a single conserved eukaryotic initiator complex termed he origin recognition complex (ORC). The ORC is a six protein complex. The function of ORC is reviewed in.


Pssm-ID: 368452 [Multi-domain]  Cd Length: 288  Bit Score: 75.77  E-value: 1.35e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462548307   6 IGRLAPRLGLAEPD-MLRKAEEYLRLSRVKCVGLSARTtETSSAVMCLDLAASWMKCPLDRAYLIKLSGLNKETYQSCLK 84
Cdd:pfam05460   1 LSDLLPTLGLGYPKkLLSKASELYRLSLVKKVMLKNNE-EIARCHICAELAAEKLSIKLDLPYAVKLIPLPPKAYAKLLD 79

                          90
                  ....*....|
gi 2462548307  85 SFECLLGLNS 94
Cdd:pfam05460  80 TFRNSLGNQS 89
Orc6_mid cd11583
Middle domain of the origin recognition complex subunit 6; Orc6 is a subunit of the origin ...
 94-150 1.12e-13

Middle domain of the origin recognition complex subunit 6; Orc6 is a subunit of the origin recognition complex in eukaryotes, and it may be involved in binding to DNA. This model describes the central or middle domain of Orc6, whose structure resembles that of TFIIB, a DNA-binding transcription factor. Orc6 appears to form distinct complexes with DNA, and a putative DNA-binding site has been identified.


Pssm-ID: 211425  Cd Length: 94  Bit Score: 63.85  E-value: 1.12e-13
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2462548307  94 SNIGIRDLAVQFSCIEAVNMASKILKSYESSLPQT-QQVDLDLSRPLFTSAALLSACK 150
Cdd:cd11583     1 SRLSVRDLAVQFGCKEAIEEAEKLLNRYKLPFLASeQRRVADFSLPQFTAAAFYLACK 58
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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