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Conserved domains on  [gi|2462549682|ref|XP_054236630|]
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leucine-rich repeat-containing protein 36 isoform X1 [Homo sapiens]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 1903219)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

CATH:  3.80.10.10
Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PPP1R42 super family cl42388
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 50-141 1.73e-11

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


The actual alignment was detected with superfamily member cd21340:

Pssm-ID: 455733 [Multi-domain]  Cd Length: 220  Bit Score: 64.04  E-value: 1.73e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462549682  50 KNLRSLDLSRNLITSLKGIQYLCSLQDLNLYYNNIPSLVEVSR-LQPLPFLKELDLRLNPVVrKDTDYRLFAVYTLQTLE 128
Cdd:cd21340   120 NSLRVLNISGNNIDSLEPLAPLRNLEQLDASNNQISDLEELLDlLSSWPSLRELDLTGNPVC-KKPKYRDKIILASKSLE 198

                          90
                  ....*....|...
gi 2462549682 129 KLDDRTVREGERK 141
Cdd:cd21340   199 VLDGKEITDTERQ 211
 
Name Accession Description Interval E-value
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 50-141 1.73e-11

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 64.04  E-value: 1.73e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462549682  50 KNLRSLDLSRNLITSLKGIQYLCSLQDLNLYYNNIPSLVEVSR-LQPLPFLKELDLRLNPVVrKDTDYRLFAVYTLQTLE 128
Cdd:cd21340   120 NSLRVLNISGNNIDSLEPLAPLRNLEQLDASNNQISDLEELLDlLSSWPSLRELDLTGNPVC-KKPKYRDKIILASKSLE 198

                          90
                  ....*....|...
gi 2462549682 129 KLDDRTVREGERK 141
Cdd:cd21340   199 VLDGKEITDTERQ 211
LRR_9 pfam14580
Leucine-rich repeat;
44-147 3.40e-09

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 56.70  E-value: 3.40e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462549682  44 DAFRNFKNLRSLDLSRNLITSL-KGI-QYLCSLQDLNLYYNNIPSLVEVSRLQPLPFLKELDLRLNPVVRKDtDYRLFAV 121
Cdd:pfam14580  58 DGFPLLRRLKTLLLNNNRICRIgEGLgEALPNLTELILTNNNLQELGDLDPLASLKKLTFLSLLRNPVTNKP-HYRLYVI 136

                          90       100
                  ....*....|....*....|....*.
gi 2462549682 122 YTLQTLEKLDDRTVREGERKAAKLHF 147
Cdd:pfam14580 137 YKVPQLRLLDFRKVKQKERQAAEKMF 162
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
27-109 2.18e-08

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 56.87  E-value: 2.18e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462549682  27 ESLSLQGSyagKIHSIGDAFRNFKNLRSLDLSRNLITSLKGIQYLCSLQDLNLYYNNIPSLvevSRLQPLPFLKELDLRL 106
Cdd:COG4886   208 EELDLSGN---QLTDLPEPLANLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDL---PPLANLTNLKTLDLSN 281


                  ...
gi 2462549682 107 NPV 109
Cdd:COG4886   282 NQL 284
 
Name Accession Description Interval E-value
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 50-141 1.73e-11

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 64.04  E-value: 1.73e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462549682  50 KNLRSLDLSRNLITSLKGIQYLCSLQDLNLYYNNIPSLVEVSR-LQPLPFLKELDLRLNPVVrKDTDYRLFAVYTLQTLE 128
Cdd:cd21340   120 NSLRVLNISGNNIDSLEPLAPLRNLEQLDASNNQISDLEELLDlLSSWPSLRELDLTGNPVC-KKPKYRDKIILASKSLE 198

                          90
                  ....*....|...
gi 2462549682 129 KLDDRTVREGERK 141
Cdd:cd21340   199 VLDGKEITDTERQ 211
LRR_9 pfam14580
Leucine-rich repeat;
44-147 3.40e-09

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 56.70  E-value: 3.40e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462549682  44 DAFRNFKNLRSLDLSRNLITSL-KGI-QYLCSLQDLNLYYNNIPSLVEVSRLQPLPFLKELDLRLNPVVRKDtDYRLFAV 121
Cdd:pfam14580  58 DGFPLLRRLKTLLLNNNRICRIgEGLgEALPNLTELILTNNNLQELGDLDPLASLKKLTFLSLLRNPVTNKP-HYRLYVI 136

                          90       100
                  ....*....|....*....|....*.
gi 2462549682 122 YTLQTLEKLDDRTVREGERKAAKLHF 147
Cdd:pfam14580 137 YKVPQLRLLDFRKVKQKERQAAEKMF 162
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
27-109 2.18e-08

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 56.87  E-value: 2.18e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462549682  27 ESLSLQGSyagKIHSIGDAFRNFKNLRSLDLSRNLITSLKGIQYLCSLQDLNLYYNNIPSLvevSRLQPLPFLKELDLRL 106
Cdd:COG4886   208 EELDLSGN---QLTDLPEPLANLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDL---PPLANLTNLKTLDLSN 281


                  ...
gi 2462549682 107 NPV 109
Cdd:COG4886   282 NQL 284
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
20-109 6.98e-08

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 55.32  E-value: 6.98e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462549682  20 LEQPELVESLSLQGSyagKIHSIGDAFRNFKNLRSLDLSRNLITSL-KGIQYLCSLQDLNLYYNNIPSLVEVsrLQPLPF 98
Cdd:COG4886   109 LSNLTNLESLDLSGN---QLTDLPEELANLTNLKELDLSNNQLTDLpEPLGNLTNLKSLDLSNNQLTDLPEE--LGNLTN 183

                          90
                  ....*....|.
gi 2462549682  99 LKELDLRLNPV 109
Cdd:COG4886   184 LKELDLSNNQI 194
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
27-109 1.59e-07

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 54.17  E-value: 1.59e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462549682  27 ESLSLQGSyagKIHSIGDAFRNFKNLRSLDLSRNLITSL-KGIQYLCSLQDLNLYYNNIPSLVEVSRlqpLPFLKELDLR 105
Cdd:COG4886   185 KELDLSNN---QITDLPEPLGNLTNLEELDLSGNQLTDLpEPLANLTNLETLDLSNNQLTDLPELGN---LTNLEELDLS 258


                  ....
gi 2462549682 106 LNPV 109
Cdd:COG4886   259 NNQL 262
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
27-109 2.19e-07

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 53.78  E-value: 2.19e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462549682  27 ESLSLQGSyagKIHSIGDAFRNFKNLRSLDLSRNLITSL-KGIQYLCSLQDLNLYYNNIPSLVEVsrLQPLPFLKELDLR 105
Cdd:COG4886   139 KELDLSNN---QLTDLPEPLGNLTNLKSLDLSNNQLTDLpEELGNLTNLKELDLSNNQITDLPEP--LGNLTNLEELDLS 213


                  ....
gi 2462549682 106 LNPV 109
Cdd:COG4886   214 GNQL 217
LRR_8 pfam13855
Leucine rich repeat;
26-84 1.16e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 43.28  E-value: 1.16e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462549682  26 VESLSLQGSYAGKIHsiGDAFRNFKNLRSLDLSRNLITSL--KGIQYLCSLQDLNLYYNNI 84
Cdd:pfam13855   3 LRSLDLSNNRLTSLD--DGAFKGLSNLKVLDLSNNLLTTLspGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
51-109 3.96e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 41.74  E-value: 3.96e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462549682  51 NLRSLDLSRNLITSLKG--IQYLCSLQDLNLYYNNIPSLVEVSrLQPLPFLKELDLRLNPV 109
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDgaFKGLSNLKVLDLSNNLLTTLSPGA-FSGLPSLRYLDLSGNRL 61
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 50-83 8.44e-05

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 40.31  E-value: 8.44e-05
                          10        20        30
                  ....*....|....*....|....*....|....
gi 2462549682  50 KNLRSLDLSRNLITSLKGIQYLCSLQDLNLYYNN 83
Cdd:pfam12799   1 PNLEVLDLSNNQITDIPPLAKLPNLETLDLSGNN 34
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 7-145 2.72e-04

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 44.01  E-value: 2.72e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462549682   7 LDEEGIRRLGALtLEQPELVESLSLQGSYAGKIH--SIGDAFRNFKNLRSLDLSRNLITS------LKGIQYLCSLQDLN 78
Cdd:COG5238   248 IGDEGVIALAEA-LKNNTTVETLYLSGNQIGAEGaiALAKALQGNTTLTSLDLSVNRIGDegaialAEGLQGNKTLHTLN 326

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2462549682  79 LYYNNIP-----SLVEVsrLQPLPFLKELDLRLNPVvrKDTDYRLFAVY--TLQTLEKLDDRTVREGERKAAKL 145
Cdd:COG5238   327 LAYNGIGaqgaiALAKA--LQENTTLHSLDLSDNQI--GDEGAIALAKYleGNTTLRELNLGKNNIGKQGAEAL 396
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 38-104 7.91e-04

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 41.31  E-value: 7.91e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2462549682  38 KIHSIgDAFRNFKNLRSLDLSRNLITSLKGIQYLCSLQDLNLYYNNIpslVEVSRLQPLPFLKELDL 104
Cdd:cd21340    35 KITKI-ENLEFLTNLTHLYLQNNQIEKIENLENLVNLKKLYLGGNRI---SVVEGLENLTNLEELHI 97
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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