NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|2507692995|ref|XP_056082902|]
View 

uncharacterized protein SMKI_09G2000 [Saccharomyces mikatae IFO 1815]

Protein Classification

IPT and Ank_2 domain-containing protein( domain architecture ID 12883544)

protein containing domains IPT, Ank_2, and COG5406

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
678-821 5.27e-16

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 80.00  E-value: 5.27e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507692995  678 GPSPNQHNVNMNTN----VFYSDEVLIQKVIKSlniNSNISICDSLGRTLLHLACLKNYSSLVYTLIKKGARVNDIDSFG 753
Cdd:COG0666    110 GADVNARDKDGETPlhlaAYNGNLEIVKLLLEA---GADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDG 186

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2507692995  754 LTPLHFACISGDPKIIKMLLNCKVNYLLKSHNGLTAKEI-FIANHVQAKDINKKQENRDNHNFVHNNNA 821
Cdd:COG0666    187 ETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLaAENGNLEIVKLLLEAGADLNAKDKDGLTA 255
IPT cd00102
Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as ...
 535-631 7.35e-14

Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor receptors), as well as, cyclodextrin glycosyltransferase and similar enzymes. Although they are involved in DNA binding in transcription factors, their function in other proteins is unknown. In these transcription factors, IPTs form homo- or heterodimers with the exception of the nuclear factor of activated Tcells (NFAT) transcription factors which are mainly monomers.


:

Pssm-ID: 238050 [Multi-domain]  Cd Length: 89  Bit Score: 68.26  E-value: 7.35e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507692995  535 PSINRVIPSQGPINGGIEVTLLGCNFKDG--LSVKFGANLALSTQCWSETTIVTYLPPAAYA--GQVFVSITDTNSENNA 610
Cdd:cd00102      1 PVITSISPSSGPVSGGTEVTITGSNFGSGsnLRVTFGGGVPCSVLSVSSTAIVCTTPPYANPgpGPVEVTVDRGNGGITS 80

                           90       100
                   ....*....|....*....|.
gi 2507692995  611 DDLPqeieindnkkaiFTYVD 631
Cdd:cd00102     81 SPLT------------FTYVP 89
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
678-821 5.27e-16

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 80.00  E-value: 5.27e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507692995  678 GPSPNQHNVNMNTN----VFYSDEVLIQKVIKSlniNSNISICDSLGRTLLHLACLKNYSSLVYTLIKKGARVNDIDSFG 753
Cdd:COG0666    110 GADVNARDKDGETPlhlaAYNGNLEIVKLLLEA---GADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDG 186

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2507692995  754 LTPLHFACISGDPKIIKMLLNCKVNYLLKSHNGLTAKEI-FIANHVQAKDINKKQENRDNHNFVHNNNA 821
Cdd:COG0666    187 ETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLaAENGNLEIVKLLLEAGADLNAKDKDGLTA 255
IPT cd00102
Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as ...
 535-631 7.35e-14

Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor receptors), as well as, cyclodextrin glycosyltransferase and similar enzymes. Although they are involved in DNA binding in transcription factors, their function in other proteins is unknown. In these transcription factors, IPTs form homo- or heterodimers with the exception of the nuclear factor of activated Tcells (NFAT) transcription factors which are mainly monomers.


Pssm-ID: 238050 [Multi-domain]  Cd Length: 89  Bit Score: 68.26  E-value: 7.35e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507692995  535 PSINRVIPSQGPINGGIEVTLLGCNFKDG--LSVKFGANLALSTQCWSETTIVTYLPPAAYA--GQVFVSITDTNSENNA 610
Cdd:cd00102      1 PVITSISPSSGPVSGGTEVTITGSNFGSGsnLRVTFGGGVPCSVLSVSSTAIVCTTPPYANPgpGPVEVTVDRGNGGITS 80

                           90       100
                   ....*....|....*....|.
gi 2507692995  611 DDLPqeieindnkkaiFTYVD 631
Cdd:cd00102     81 SPLT------------FTYVP 89
IPT smart00429
ig-like, plexins, transcription factors;
534-600 9.13e-12

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 62.05  E-value: 9.13e-12
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2507692995   534 LPSINRVIPSQGPINGGIEVTLLGCNFKDGLSVKFGANL---ALSTQCWSETTIVTYLPPAA-YAGQVFVS 600
Cdd:smart00429    1 DPVITRISPTSGPVSGGTEITLCGKNLKSISVVFVEVGVgeaPCTFSPSSSTAIVCKTPPYHnIPGSVPVR 71
Ank_2 pfam12796
Ankyrin repeats (3 copies);
707-782 4.41e-11

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 60.13  E-value: 4.41e-11
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2507692995  707 LNINSNISICDSLGRTLLHLACLKNYSSLVYTLIKKGARvnDIDSFGLTPLHFACISGDPKIIKMLLNCKVNYLLK 782
Cdd:pfam12796   17 LENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADV--NLKDNGRTALHYAARSGHLEIVKLLLEKGADINVK 90
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 707-778 4.48e-07

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 53.52  E-value: 4.48e-07
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2507692995  707 LNINSNISICDSLGRTLLHLACLKNYSSLVYTLIKKGARVNDIDSFGLTPLHFACISGDPKIIKMLLNCKVN 778
Cdd:PHA03100   179 LSYGVPINIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLLLNNGPS 250
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 535-602 1.09e-06

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 47.44  E-value: 1.09e-06
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2507692995  535 PSINRVIPSQGPINGGIEVTLLGCNF---KDGLSVKFGANLALSTQcWSETTIVTYLPPAAyAGQVFVSIT 602
Cdd:pfam01833    1 PVITSISPSSGPASGGTTITITGSNFgtdSSDLKVTIGGTPCTVIS-VSSTTIVCTTPPGT-SGLVNVSVT 69
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 753-778 2.26e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 36.41  E-value: 2.26e-03
                            10        20
                    ....*....|....*....|....*.
gi 2507692995   753 GLTPLHFACISGDPKIIKMLLNCKVN 778
Cdd:smart00248    2 GRTPLHLAAENGNLEVVKLLLDKGAD 27
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
678-821 5.27e-16

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 80.00  E-value: 5.27e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507692995  678 GPSPNQHNVNMNTN----VFYSDEVLIQKVIKSlniNSNISICDSLGRTLLHLACLKNYSSLVYTLIKKGARVNDIDSFG 753
Cdd:COG0666    110 GADVNARDKDGETPlhlaAYNGNLEIVKLLLEA---GADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDG 186

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2507692995  754 LTPLHFACISGDPKIIKMLLNCKVNYLLKSHNGLTAKEI-FIANHVQAKDINKKQENRDNHNFVHNNNA 821
Cdd:COG0666    187 ETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLaAENGNLEIVKLLLEAGADLNAKDKDGLTA 255
IPT cd00102
Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as ...
 535-631 7.35e-14

Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor receptors), as well as, cyclodextrin glycosyltransferase and similar enzymes. Although they are involved in DNA binding in transcription factors, their function in other proteins is unknown. In these transcription factors, IPTs form homo- or heterodimers with the exception of the nuclear factor of activated Tcells (NFAT) transcription factors which are mainly monomers.


Pssm-ID: 238050 [Multi-domain]  Cd Length: 89  Bit Score: 68.26  E-value: 7.35e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507692995  535 PSINRVIPSQGPINGGIEVTLLGCNFKDG--LSVKFGANLALSTQCWSETTIVTYLPPAAYA--GQVFVSITDTNSENNA 610
Cdd:cd00102      1 PVITSISPSSGPVSGGTEVTITGSNFGSGsnLRVTFGGGVPCSVLSVSSTAIVCTTPPYANPgpGPVEVTVDRGNGGITS 80

                           90       100
                   ....*....|....*....|.
gi 2507692995  611 DDLPqeieindnkkaiFTYVD 631
Cdd:cd00102     81 SPLT------------FTYVP 89
IPT smart00429
ig-like, plexins, transcription factors;
534-600 9.13e-12

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 62.05  E-value: 9.13e-12
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2507692995   534 LPSINRVIPSQGPINGGIEVTLLGCNFKDGLSVKFGANL---ALSTQCWSETTIVTYLPPAA-YAGQVFVS 600
Cdd:smart00429    1 DPVITRISPTSGPVSGGTEITLCGKNLKSISVVFVEVGVgeaPCTFSPSSSTAIVCKTPPYHnIPGSVPVR 71
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
699-789 2.10e-11

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 66.13  E-value: 2.10e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507692995  699 LIQKVIKSLNINSNISICDSLGRTLLHLACLKNYSSLVYTLIKKGARVNDIDSFGLTPLHFACISGDPKIIKMLLNCKVN 778
Cdd:COG0666     66 DLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGAD 145

                           90
                   ....*....|.
gi 2507692995  779 YLLKSHNGLTA 789
Cdd:COG0666    146 VNAQDNDGNTP 156
Ank_2 pfam12796
Ankyrin repeats (3 copies);
707-782 4.41e-11

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 60.13  E-value: 4.41e-11
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2507692995  707 LNINSNISICDSLGRTLLHLACLKNYSSLVYTLIKKGARvnDIDSFGLTPLHFACISGDPKIIKMLLNCKVNYLLK 782
Cdd:pfam12796   17 LENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADV--NLKDNGRTALHYAARSGHLEIVKLLLEKGADINVK 90
Ank_2 pfam12796
Ankyrin repeats (3 copies);
724-789 8.00e-11

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 59.36  E-value: 8.00e-11
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2507692995  724 LHLACLKNYSSLVYTLIKKGARVNDIDSFGLTPLHFACISGDPKIIKMLLN-CKVNyllKSHNGLTA 789
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEhADVN---LKDNGRTA 64
Ank_4 pfam13637
Ankyrin repeats (many copies);
720-773 1.39e-10

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 57.67  E-value: 1.39e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 2507692995  720 GRTLLHLACLKNYSSLVYTLIKKGARVNDIDSFGLTPLHFACISGDPKIIKMLL 773
Cdd:pfam13637    1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 707-778 4.48e-07

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 53.52  E-value: 4.48e-07
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2507692995  707 LNINSNISICDSLGRTLLHLACLKNYSSLVYTLIKKGARVNDIDSFGLTPLHFACISGDPKIIKMLLNCKVN 778
Cdd:PHA03100   179 LSYGVPINIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLLLNNGPS 250
PHA03095 PHA03095
ankyrin-like protein; Provisional
 694-832 5.09e-07

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 53.49  E-value: 5.09e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507692995  694 YSDEVLIQKVIKSLNINSNISICDSLGRTLLHLaCLKNYSSL----VYTLIKKGARVNDIDSFGLTPLH-FACISGDPKI 768
Cdd:PHA03095    21 NASNVTVEEVRRLLAAGADVNFRGEYGKTPLHL-YLHYSSEKvkdiVRLLLEAGADVNAPERCGFTPLHlYLYNATTLDV 99

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507692995  769 IKMLLNCKVNYLLKSHNGLTAKEIFIANhvqaKDINKKQ-----------ENRDNHN------FVHNNNAYVNEVLSLFE 831
Cdd:PHA03095   100 IKLLIKAGADVNAKDKVGRTPLHVYLSG----FNINPKVirlllrkgadvNALDLYGmtplavLLKSRNANVELLRLLID 175


                   .
gi 2507692995  832 V 832
Cdd:PHA03095   176 A 176
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 535-602 1.09e-06

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 47.44  E-value: 1.09e-06
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2507692995  535 PSINRVIPSQGPINGGIEVTLLGCNF---KDGLSVKFGANLALSTQcWSETTIVTYLPPAAyAGQVFVSIT 602
Cdd:pfam01833    1 PVITSISPSSGPASGGTTITITGSNFgtdSSDLKVTIGGTPCTVIS-VSSTTIVCTTPPGT-SGLVNVSVT 69
IPT_COE cd01175
IPT domain of the COE family (Col/Olf-1/EBF) of non-basic, helix-loop-helix (HLH)-containing ...
 535-602 2.21e-06

IPT domain of the COE family (Col/Olf-1/EBF) of non-basic, helix-loop-helix (HLH)-containing transcription factors. COE family proteins are all transcription factors and play an important role in variety of developmental processes. Mouse EBF is involved in the regulation of the early stages of B-cell differentiation, Drosophila collier is a regulator of the head patterning, and a related protein in Xenopus is involved in primary neurogenesis. All COE family members have a well conserved DNA binding domain that contains an atypical Zn finger motif. The function of the IPT domain is unknown.


Pssm-ID: 238580  Cd Length: 85  Bit Score: 46.87  E-value: 2.21e-06
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2507692995  535 PSINRVIPSQGPINGGIEVTLLGCNFKDGLSVKFGANLALStQCWSETTIVTYLPPAAYAGQVFVSIT 602
Cdd:cd01175      1 PCIKAISPSEGWTTGGATVIIIGDNFFDGLQVVFGTMLVWS-ELITPHAIRVQTPPRHIPGVVEVTLS 67
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 535-631 2.91e-05

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 43.60  E-value: 2.91e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507692995  535 PSINRVIPSQGPINGGIEVTLLGCNF---KDGLSVKFGanlalSTQC----WSETTIVTYLPPAAYAGQ--VFVSItdtn 605
Cdd:cd00603      1 PVITSISPSSGPLSGGTRLTITGSNLgsgSPRVRVTVG-----GVPCkvlnVSSTEIVCRTPAAATPGEgpVEVTV---- 71

                           90       100
                   ....*....|....*....|....*.
gi 2507692995  606 sennadDLPQEIEINDNKKaIFTYVD 631
Cdd:cd00603     72 ------DGANVSARVLSNT-TFTYVE 90
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 677-788 5.91e-05

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 46.88  E-value: 5.91e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507692995  677 TGPSPNQHNVNMNTNVFYSDEVLIQKVIKSL-NINSNISICDSLGRTLLHLACLKNYSSLVYTLIKKGARVNDIDSFGLT 755
Cdd:PHA02874   113 CGIDVNIKDAELKTFLHYAIKKGDLESIKMLfEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVKDNNGES 192

                           90       100       110
                   ....*....|....*....|....*....|...
gi 2507692995  756 PLHFACISGDPKIIKMLLNCKVNYLLKSHNGLT 788
Cdd:PHA02874   193 PLHNAAEYGDYACIKLLIDHGNHIMNKCKNGFT 225
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
682-789 1.26e-04

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 45.33  E-value: 1.26e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507692995  682 NQHNVNMNTNVFYSDEVLIQKVIKSLNINSNISICDSLGRTLLHLACLKNYSSLVYTLIKKGARVNDIDSFGLTPLHFAC 761
Cdd:COG0666     16 LLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAA 95

                           90       100
                   ....*....|....*....|....*...
gi 2507692995  762 ISGDPKIIKMLLNCKVNYLLKSHNGLTA 789
Cdd:COG0666     96 RNGDLEIVKLLLEAGADVNARDKDGETP 123
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 752-779 1.35e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 39.93  E-value: 1.35e-04
                           10        20
                   ....*....|....*....|....*...
gi 2507692995  752 FGLTPLHFACISGDPKIIKMLLNCKVNY 779
Cdd:pfam13606    1 DGNTPLHLAARNGRLEIVKLLLENGADI 28
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 707-797 3.49e-04

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 44.27  E-value: 3.49e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507692995  707 LNINSNISICDSLGRTLLHLA--CLKNYSSLVYTLIKKGARVNDIDS----------------FGLTPLHFACISGDPKI 768
Cdd:PHA03100   128 LDNGANVNIKNSDGENLLHLYleSNKIDLKILKLLIDKGVDINAKNRvnyllsygvpinikdvYGFTPLHYAVYNNNPEF 207

                           90       100
                   ....*....|....*....|....*....
gi 2507692995  769 IKMLLNCKVNYLLKSHNGLTAKEIFIANH 797
Cdd:PHA03100   208 VKYLLDLGANPNLVNKYGDTPLHIAILNN 236
Ank_5 pfam13857
Ankyrin repeats (many copies);
739-792 5.14e-04

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 39.25  E-value: 5.14e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 2507692995  739 LIKKG-ARVNDIDSFGLTPLHFACISGDPKIIKMLLNCKVNYLLKSHNGLTAKEI 792
Cdd:pfam13857    1 LLEHGpIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDL 55
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 627-796 7.24e-04

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 43.70  E-value: 7.24e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507692995  627 FTYVDDTDRQLIELALQIVGLKMNGKLEDARNIAKRIVGNDSPDSGTNGSTGPSPN---QHNVNMNTNVF----YSDEVL 699
Cdd:PLN03192   461 FTFRTKTLSQLLRLKTSTLIEAMQTRQEDNVVILKNFLQHHKELHDLNVGDLLGDNggeHDDPNMASNLLtvasTGNAAL 540

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507692995  700 IQKVIKSlniNSNISICDSLGRTLLHLACLKNYSSLVYTLIKKGARVNDIDSFGLTPL----------------HFACIS 763
Cdd:PLN03192   541 LEELLKA---KLDPDIGDSKGRTPLHIAASKGYEDCVLVLLKHACNVHIRDANGNTALwnaisakhhkifrilyHFASIS 617

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*...
gi 2507692995  764 ---------------GDPKIIKMLLNCKVNYLLKSHNGLTAKEIFIAN 796
Cdd:PLN03192   618 dphaagdllctaakrNDLTAMKELLKQGLNVDSEDHQGATALQVAMAE 665
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 717-775 8.75e-04

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 43.35  E-value: 8.75e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 2507692995  717 DSLGRTLLHLACLKNYSSLVYTLIKKGARVNDIDSFGLTPLHFACISGDPKIIKMLLNC 775
Cdd:PTZ00322   112 DYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLSRH 170
Ank_5 pfam13857
Ankyrin repeats (many copies);
717-760 9.65e-04

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 38.48  E-value: 9.65e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 2507692995  717 DSLGRTLLHLACLKNYSSLVYTLIKKGARVNDIDSFGLTPLHFA 760
Cdd:pfam13857   13 DGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
PHA03095 PHA03095
ankyrin-like protein; Provisional
 678-774 1.21e-03

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 42.70  E-value: 1.21e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507692995  678 GPSPNQHNVNMNTNVFYSDEVLIQKVIKSLNI---NSNISICDSLGRTLLHLACLKNYSSLVYTLIKKGARVNDIDSFGL 754
Cdd:PHA03095   212 GCDPAATDMLGNTPLHSMATGSSCKRSLVLPLliaGISINARNRYGQTPLHYAAVFNNPRACRRLIALGADINAVSSDGN 291

                           90       100
                   ....*....|....*....|
gi 2507692995  755 TPLHFACISGDPKIIKMLLN 774
Cdd:PHA03095   292 TPLSLMVRNNNGRAVRAALA 311
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 753-778 2.26e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 36.41  E-value: 2.26e-03
                            10        20
                    ....*....|....*....|....*.
gi 2507692995   753 GLTPLHFACISGDPKIIKMLLNCKVN 778
Cdd:smart00248    2 GRTPLHLAAENGNLEVVKLLLDKGAD 27
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 722-774 4.95e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 40.82  E-value: 4.95e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 2507692995  722 TLLHLA-CLKNYSSLVYTLIKKGARVNDIDSFGLTPLHFACISG-DPKIIKMLLN 774
Cdd:PHA02876   410 TALHFAlCGTNPYMSVKTLIDRGANVNSKNKDLSTPLHYACKKNcKLDVIEMLLD 464
IPT_plexin_repeat1 cd01180
First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 535-566 8.05e-03

First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238585  Cd Length: 94  Bit Score: 36.91  E-value: 8.05e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 2507692995  535 PSINRVIPSQGPINGGIEVTLLGCNFkdGLSV 566
Cdd:cd01180      1 PVITEFFPLSGPLEGGTRLTICGSNL--GLRK 30
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 700-778 9.76e-03

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 39.65  E-value: 9.76e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507692995  700 IQKVIKSLNINSNISICDSLGRTLLHLACLKNYSS-----LVYTLIKKGARVNDIDSFGLTPLHFACI--SGDPKIIKML 772
Cdd:PHA03100    48 IDVVKILLDNGADINSSTKNNSTPLHYLSNIKYNLtdvkeIVKLLLEYGANVNAPDNNGITPLLYAISkkSNSYSIVEYL 127


                   ....*...
gi 2507692995  773 L--NCKVN 778
Cdd:PHA03100   128 LdnGANVN 135
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH