NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|2756282421|ref|XP_066160374|]
View 

uncharacterized protein [Oryza sativa Japonica Group]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
MCD super family cl09364
Malonyl-CoA decarboxylase C-terminal domain; This family consists of several eukaryotic ...
 206-496 4.35e-115

Malonyl-CoA decarboxylase C-terminal domain; This family consists of several eukaryotic malonyl-CoA decarboxylase (MLYCD) proteins. Malonyl-CoA, in addition to being an intermediate in the de novo synthesis of fatty acids, is an inhibitor of carnitine palmitoyltransferase I, the enzyme that regulates the transfer of long-chain fatty acyl-CoA into mitochondria, where they are oxidized. After exercise, malonyl-CoA decarboxylase participates with acetyl-CoA carboxylase in regulating the concentration of malonyl-CoA in liver and adipose tissue, as well as in muscle. Malonyl-CoA decarboxylase is regulated by AMP-activated protein kinase (AMPK).


The actual alignment was detected with superfamily member pfam05292:

Pssm-ID: 461613  Cd Length: 245  Bit Score: 340.31  E-value: 4.35e-115
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2756282421 206 LTLHQITWDDPASLLEKIVAYEAVHPIRNLIDLKRRLGVGRRCFGYFHPAIPGEPLIFIEVALLKDTAASIQEVL-WDDP 284
Cdd:pfam05292   3 LELRRITWDSPASLLEKIIRYEAVHEIRGWDDLRRRLDSDRRCFAFFHPALPDEPLIFVEVALVDEIADSIQPLLdEDAP 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2756282421 285 PTPESEARCALFYSISSTQPGLSGINLGKFLLKRVIEMLRRDMPSvqsicfvcwhfIQIFATLSPIPGFMQWLLAKLASQ 364
Cdd:pfam05292  83 PIDPEKATTAIFYSISNTQVGLRGISFGNFLIKRVVEELQREFPN-----------LKTFATLSPIPGFRRWLDRELAKE 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2756282421 365 iklaeaesqdgsllegtsstfRESILFPEEERMIHDavehaggksgikllqdiLKSSQWVKSDKLSSALKSPLMRLCARY 444
Cdd:pfam05292 152 ---------------------SDALLSAEDREALAA-----------------LDDPEWHEDPELAEALREPLLRLAARY 193

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2756282421 445 LAREKKRGKALDAVANFHLQNGAMIERINWMADQSEKGIQQSGGIMVNYMYR 496
Cdd:pfam05292 194 LLRAKRDGRPLDPVARFHLGNGARLERLNWLGDTSAKGLKQSYGLMVNYLYD 245
MCD_N super family cl38688
Malonyl-CoA decarboxylase N-terminal domain; This family consists of several eukaryotic ...
 137-200 2.97e-07

Malonyl-CoA decarboxylase N-terminal domain; This family consists of several eukaryotic malonyl-CoA decarboxylase (MLYCD) proteins. Malonyl-CoA, in addition to being an intermediate in the de novo synthesis of fatty acids, is an inhibitor of carnitine palmitoyltransferase I, the enzyme that regulates the transfer of long-chain fatty acyl-CoA into mitochondria, where they are oxidized. After exercise, malonyl-CoA decarboxylase participates with acetyl-CoA carboxylase in regulating the concentration of malonyl-CoA in liver and adipose tissue, as well as in muscle. Malonyl-CoA decarboxylase is regulated by AMP-activated protein kinase (AMPK).


The actual alignment was detected with superfamily member pfam17408:

Pssm-ID: 465421  Cd Length: 85  Bit Score: 48.34  E-value: 2.97e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2756282421 137 RMERGLREALRPKYAGFLEAMNAQPGGLKLLAVIRADLLALLGEEnlPALRALDGYLKEKLVTW 200
Cdd:pfam17408  23 AAEAELRRALEPRRQELLRRFNLAPGGTKFLVDMRADLLALLKGN--PDLRALDRDLEHLLSSW 84
 
Name Accession Description Interval E-value
MCD pfam05292
Malonyl-CoA decarboxylase C-terminal domain; This family consists of several eukaryotic ...
 206-496 4.35e-115

Malonyl-CoA decarboxylase C-terminal domain; This family consists of several eukaryotic malonyl-CoA decarboxylase (MLYCD) proteins. Malonyl-CoA, in addition to being an intermediate in the de novo synthesis of fatty acids, is an inhibitor of carnitine palmitoyltransferase I, the enzyme that regulates the transfer of long-chain fatty acyl-CoA into mitochondria, where they are oxidized. After exercise, malonyl-CoA decarboxylase participates with acetyl-CoA carboxylase in regulating the concentration of malonyl-CoA in liver and adipose tissue, as well as in muscle. Malonyl-CoA decarboxylase is regulated by AMP-activated protein kinase (AMPK).


Pssm-ID: 461613  Cd Length: 245  Bit Score: 340.31  E-value: 4.35e-115
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2756282421 206 LTLHQITWDDPASLLEKIVAYEAVHPIRNLIDLKRRLGVGRRCFGYFHPAIPGEPLIFIEVALLKDTAASIQEVL-WDDP 284
Cdd:pfam05292   3 LELRRITWDSPASLLEKIIRYEAVHEIRGWDDLRRRLDSDRRCFAFFHPALPDEPLIFVEVALVDEIADSIQPLLdEDAP 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2756282421 285 PTPESEARCALFYSISSTQPGLSGINLGKFLLKRVIEMLRRDMPSvqsicfvcwhfIQIFATLSPIPGFMQWLLAKLASQ 364
Cdd:pfam05292  83 PIDPEKATTAIFYSISNTQVGLRGISFGNFLIKRVVEELQREFPN-----------LKTFATLSPIPGFRRWLDRELAKE 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2756282421 365 iklaeaesqdgsllegtsstfRESILFPEEERMIHDavehaggksgikllqdiLKSSQWVKSDKLSSALKSPLMRLCARY 444
Cdd:pfam05292 152 ---------------------SDALLSAEDREALAA-----------------LDDPEWHEDPELAEALREPLLRLAARY 193

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2756282421 445 LAREKKRGKALDAVANFHLQNGAMIERINWMADQSEKGIQQSGGIMVNYMYR 496
Cdd:pfam05292 194 LLRAKRDGRPLDPVARFHLGNGARLERLNWLGDTSAKGLKQSYGLMVNYLYD 245
MCD_N pfam17408
Malonyl-CoA decarboxylase N-terminal domain; This family consists of several eukaryotic ...
 137-200 2.97e-07

Malonyl-CoA decarboxylase N-terminal domain; This family consists of several eukaryotic malonyl-CoA decarboxylase (MLYCD) proteins. Malonyl-CoA, in addition to being an intermediate in the de novo synthesis of fatty acids, is an inhibitor of carnitine palmitoyltransferase I, the enzyme that regulates the transfer of long-chain fatty acyl-CoA into mitochondria, where they are oxidized. After exercise, malonyl-CoA decarboxylase participates with acetyl-CoA carboxylase in regulating the concentration of malonyl-CoA in liver and adipose tissue, as well as in muscle. Malonyl-CoA decarboxylase is regulated by AMP-activated protein kinase (AMPK).


Pssm-ID: 465421  Cd Length: 85  Bit Score: 48.34  E-value: 2.97e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2756282421 137 RMERGLREALRPKYAGFLEAMNAQPGGLKLLAVIRADLLALLGEEnlPALRALDGYLKEKLVTW 200
Cdd:pfam17408  23 AAEAELRRALEPRRQELLRRFNLAPGGTKFLVDMRADLLALLKGN--PDLRALDRDLEHLLSSW 84
 
Name Accession Description Interval E-value
MCD pfam05292
Malonyl-CoA decarboxylase C-terminal domain; This family consists of several eukaryotic ...
 206-496 4.35e-115

Malonyl-CoA decarboxylase C-terminal domain; This family consists of several eukaryotic malonyl-CoA decarboxylase (MLYCD) proteins. Malonyl-CoA, in addition to being an intermediate in the de novo synthesis of fatty acids, is an inhibitor of carnitine palmitoyltransferase I, the enzyme that regulates the transfer of long-chain fatty acyl-CoA into mitochondria, where they are oxidized. After exercise, malonyl-CoA decarboxylase participates with acetyl-CoA carboxylase in regulating the concentration of malonyl-CoA in liver and adipose tissue, as well as in muscle. Malonyl-CoA decarboxylase is regulated by AMP-activated protein kinase (AMPK).


Pssm-ID: 461613  Cd Length: 245  Bit Score: 340.31  E-value: 4.35e-115
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2756282421 206 LTLHQITWDDPASLLEKIVAYEAVHPIRNLIDLKRRLGVGRRCFGYFHPAIPGEPLIFIEVALLKDTAASIQEVL-WDDP 284
Cdd:pfam05292   3 LELRRITWDSPASLLEKIIRYEAVHEIRGWDDLRRRLDSDRRCFAFFHPALPDEPLIFVEVALVDEIADSIQPLLdEDAP 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2756282421 285 PTPESEARCALFYSISSTQPGLSGINLGKFLLKRVIEMLRRDMPSvqsicfvcwhfIQIFATLSPIPGFMQWLLAKLASQ 364
Cdd:pfam05292  83 PIDPEKATTAIFYSISNTQVGLRGISFGNFLIKRVVEELQREFPN-----------LKTFATLSPIPGFRRWLDRELAKE 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2756282421 365 iklaeaesqdgsllegtsstfRESILFPEEERMIHDavehaggksgikllqdiLKSSQWVKSDKLSSALKSPLMRLCARY 444
Cdd:pfam05292 152 ---------------------SDALLSAEDREALAA-----------------LDDPEWHEDPELAEALREPLLRLAARY 193

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2756282421 445 LAREKKRGKALDAVANFHLQNGAMIERINWMADQSEKGIQQSGGIMVNYMYR 496
Cdd:pfam05292 194 LLRAKRDGRPLDPVARFHLGNGARLERLNWLGDTSAKGLKQSYGLMVNYLYD 245
MCD_N pfam17408
Malonyl-CoA decarboxylase N-terminal domain; This family consists of several eukaryotic ...
 137-200 2.97e-07

Malonyl-CoA decarboxylase N-terminal domain; This family consists of several eukaryotic malonyl-CoA decarboxylase (MLYCD) proteins. Malonyl-CoA, in addition to being an intermediate in the de novo synthesis of fatty acids, is an inhibitor of carnitine palmitoyltransferase I, the enzyme that regulates the transfer of long-chain fatty acyl-CoA into mitochondria, where they are oxidized. After exercise, malonyl-CoA decarboxylase participates with acetyl-CoA carboxylase in regulating the concentration of malonyl-CoA in liver and adipose tissue, as well as in muscle. Malonyl-CoA decarboxylase is regulated by AMP-activated protein kinase (AMPK).


Pssm-ID: 465421  Cd Length: 85  Bit Score: 48.34  E-value: 2.97e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2756282421 137 RMERGLREALRPKYAGFLEAMNAQPGGLKLLAVIRADLLALLGEEnlPALRALDGYLKEKLVTW 200
Cdd:pfam17408  23 AAEAELRRALEPRRQELLRRFNLAPGGTKFLVDMRADLLALLKGN--PDLRALDRDLEHLLSSW 84
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH