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Conserved domains on  [gi|2756267615|ref|XP_066167373|]
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putative disease resistance RPP13-like protein 3 isoform X2 [Oryza sativa Japonica Group]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NB-ARC super family cl26397
NB-ARC domain;
126-283 3.28e-25

NB-ARC domain;


The actual alignment was detected with superfamily member pfam00931:

Pssm-ID: 395745 [Multi-domain]  Cd Length: 245  Bit Score: 100.92  E-value: 3.28e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2756267615 126 KVIFVVGMGGLGKTSLVKKVYH-SINIVNNFSCRAWVTVSQSFVRTELLRGLIKQLlggdsenehfkGLQSMQRNEKVE- 203
Cdd:pfam00931  19 GIVGIHGMGGVGKTTLAAQIFNdFDEVEGHFDSVAWVVVSKTFTISTLQQTILQNL-----------GLSEDDWDNKEEg 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2756267615 204 DLVEDLKQGLKEKRYFVVLDDMWsiDALNWLNESV-FPDSNNgGSRIIVTTRDASIIQNCAYPSYLYRLEPLKTDDAKQL 282
Cdd:pfam00931  88 ELARKIRRALLTKRFLLVLDDVW--DEEDWDKIGIpLPDREN-GCRVLLTTRSEEVAGRVGGPSDPHEVELLEPDEAWEL 164


                  .
gi 2756267615 283 L 283
Cdd:pfam00931 165 F 165
RX-CC_like cd14798
Coiled-coil domain of the potato virux X resistance protein and similar proteins; The potato ...
 8-67 2.22e-11

Coiled-coil domain of the potato virux X resistance protein and similar proteins; The potato virus X resistance protein (RX) confers resistance against potato virus X. It is a member of a family of resistance proteins with a domain architecture that includes an N-terminal coiled-coil domain (modeled here), a nucleotide-binding domain, and leucine-rich repeats (CC-NB-LRR). These intracellular resistance proteins recognize pathogen effector proteins and will subsequently trigger a response that may be as severe as localized cell death. The N-terminal coiled-coil domain of RX has been shown to interact with RanGAP2, which is a necessary co-factor in the resistance response.


:

Pssm-ID: 271353 [Multi-domain]  Cd Length: 124  Bit Score: 59.94  E-value: 2.22e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2756267615   8 LKAWVEQVRDLSFDIEDCLAEFMVHVGSKSLSQQLM--------KLKHRHRIAIQIRDLKSRVEEVSD 67
Cdd:cd14798    57 LKDWVKQVRDVAYDAEDIIDSFLLKLVPDKRRGGFLkrlfsllkELKELHQVAKEIQSIKSRIKDISS 124
P-loop_NTPase super family cl38936
P-loop containing Nucleoside Triphosphate Hydrolases; Members of the P-loop NTPase domain ...
 94-150 9.53e-03

P-loop containing Nucleoside Triphosphate Hydrolases; Members of the P-loop NTPase domain superfamily are characterized by a conserved nucleotide phosphate-binding motif, also referred to as the Walker A motif (GxxxxGK[S/T], where x is any residue), and the Walker B motif (hhhh[D/E], where h is a hydrophobic residue). The Walker A and B motifs bind the beta-gamma phosphate moiety of the bound nucleotide (typically ATP or GTP) and the Mg2+ cation, respectively. The P-loop NTPases are involved in diverse cellular functions, and they can be divided into two major structural classes: the KG (kinase-GTPase) class which includes Ras-like GTPases and its circularly permutated YlqF-like; and the ASCE (additional strand catalytic E) class which includes ATPase Binding Cassette (ABC), DExD/H-like helicases, 4Fe-4S iron sulfur cluster binding proteins of NifH family, RecA-like F1-ATPases, and ATPases Associated with a wide variety of Activities (AAA). Also included are a diverse set of nucleotide/nucleoside kinase families.


The actual alignment was detected with superfamily member cd19500:

Pssm-ID: 476819 [Multi-domain]  Cd Length: 182  Bit Score: 36.38  E-value: 9.53e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2756267615  94 AKNIDEAELVGFDDAKESILNLIDVHA--NHGLAKVIFVVGMGGLGKTSLVKKVYHSIN 150
Cdd:cd19500     4 ARKVLDADHYGLEDVKERILEYLAVRKlkGSMKGPILCLVGPPGVGKTSLGKSIARALG 62
 
Name Accession Description Interval E-value
NB-ARC pfam00931
NB-ARC domain;
126-283 3.28e-25

NB-ARC domain;


Pssm-ID: 395745 [Multi-domain]  Cd Length: 245  Bit Score: 100.92  E-value: 3.28e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2756267615 126 KVIFVVGMGGLGKTSLVKKVYH-SINIVNNFSCRAWVTVSQSFVRTELLRGLIKQLlggdsenehfkGLQSMQRNEKVE- 203
Cdd:pfam00931  19 GIVGIHGMGGVGKTTLAAQIFNdFDEVEGHFDSVAWVVVSKTFTISTLQQTILQNL-----------GLSEDDWDNKEEg 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2756267615 204 DLVEDLKQGLKEKRYFVVLDDMWsiDALNWLNESV-FPDSNNgGSRIIVTTRDASIIQNCAYPSYLYRLEPLKTDDAKQL 282
Cdd:pfam00931  88 ELARKIRRALLTKRFLLVLDDVW--DEEDWDKIGIpLPDREN-GCRVLLTTRSEEVAGRVGGPSDPHEVELLEPDEAWEL 164


                  .
gi 2756267615 283 L 283
Cdd:pfam00931 165 F 165
RX-CC_like cd14798
Coiled-coil domain of the potato virux X resistance protein and similar proteins; The potato ...
 8-67 2.22e-11

Coiled-coil domain of the potato virux X resistance protein and similar proteins; The potato virus X resistance protein (RX) confers resistance against potato virus X. It is a member of a family of resistance proteins with a domain architecture that includes an N-terminal coiled-coil domain (modeled here), a nucleotide-binding domain, and leucine-rich repeats (CC-NB-LRR). These intracellular resistance proteins recognize pathogen effector proteins and will subsequently trigger a response that may be as severe as localized cell death. The N-terminal coiled-coil domain of RX has been shown to interact with RanGAP2, which is a necessary co-factor in the resistance response.


Pssm-ID: 271353 [Multi-domain]  Cd Length: 124  Bit Score: 59.94  E-value: 2.22e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2756267615   8 LKAWVEQVRDLSFDIEDCLAEFMVHVGSKSLSQQLM--------KLKHRHRIAIQIRDLKSRVEEVSD 67
Cdd:cd14798    57 LKDWVKQVRDVAYDAEDIIDSFLLKLVPDKRRGGFLkrlfsllkELKELHQVAKEIQSIKSRIKDISS 124
Rx_N pfam18052
Rx N-terminal domain; This entry represents the N-terminal domain found in many plant ...
 8-47 4.98e-07

Rx N-terminal domain; This entry represents the N-terminal domain found in many plant resistance proteins. This domain has been predicted to be a coiled-coil, however the structure shows that it adopts a four helical bundle fold.


Pssm-ID: 436239  Cd Length: 93  Bit Score: 46.88  E-value: 4.98e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 2756267615   8 LKAWVEQVRDLSFDIEDCLAEFMVHVGSKSLSQQLMKLKH 47
Cdd:pfam18052  54 VKLWLKQLRDVAYDAEDVLDEFLYEALRRKSSPKKLKFRH 93
RecA-like_Lon cd19500
lon protease homolog 2 peroxisomal; Lon protease (also known as Lon peptidase) is an ...
 94-150 9.53e-03

lon protease homolog 2 peroxisomal; Lon protease (also known as Lon peptidase) is an evolutionarily conserved ATP-dependent serine protease, present in bacteria and eukaryotic mitochondria and peroxisomes, which mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Lon protease is both an ATP-dependent peptidase and a protein-activated ATPase. This RecA-like Lon domain subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410908 [Multi-domain]  Cd Length: 182  Bit Score: 36.38  E-value: 9.53e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2756267615  94 AKNIDEAELVGFDDAKESILNLIDVHA--NHGLAKVIFVVGMGGLGKTSLVKKVYHSIN 150
Cdd:cd19500     4 ARKVLDADHYGLEDVKERILEYLAVRKlkGSMKGPILCLVGPPGVGKTSLGKSIARALG 62
 
Name Accession Description Interval E-value
NB-ARC pfam00931
NB-ARC domain;
126-283 3.28e-25

NB-ARC domain;


Pssm-ID: 395745 [Multi-domain]  Cd Length: 245  Bit Score: 100.92  E-value: 3.28e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2756267615 126 KVIFVVGMGGLGKTSLVKKVYH-SINIVNNFSCRAWVTVSQSFVRTELLRGLIKQLlggdsenehfkGLQSMQRNEKVE- 203
Cdd:pfam00931  19 GIVGIHGMGGVGKTTLAAQIFNdFDEVEGHFDSVAWVVVSKTFTISTLQQTILQNL-----------GLSEDDWDNKEEg 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2756267615 204 DLVEDLKQGLKEKRYFVVLDDMWsiDALNWLNESV-FPDSNNgGSRIIVTTRDASIIQNCAYPSYLYRLEPLKTDDAKQL 282
Cdd:pfam00931  88 ELARKIRRALLTKRFLLVLDDVW--DEEDWDKIGIpLPDREN-GCRVLLTTRSEEVAGRVGGPSDPHEVELLEPDEAWEL 164


                  .
gi 2756267615 283 L 283
Cdd:pfam00931 165 F 165
RX-CC_like cd14798
Coiled-coil domain of the potato virux X resistance protein and similar proteins; The potato ...
 8-67 2.22e-11

Coiled-coil domain of the potato virux X resistance protein and similar proteins; The potato virus X resistance protein (RX) confers resistance against potato virus X. It is a member of a family of resistance proteins with a domain architecture that includes an N-terminal coiled-coil domain (modeled here), a nucleotide-binding domain, and leucine-rich repeats (CC-NB-LRR). These intracellular resistance proteins recognize pathogen effector proteins and will subsequently trigger a response that may be as severe as localized cell death. The N-terminal coiled-coil domain of RX has been shown to interact with RanGAP2, which is a necessary co-factor in the resistance response.


Pssm-ID: 271353 [Multi-domain]  Cd Length: 124  Bit Score: 59.94  E-value: 2.22e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2756267615   8 LKAWVEQVRDLSFDIEDCLAEFMVHVGSKSLSQQLM--------KLKHRHRIAIQIRDLKSRVEEVSD 67
Cdd:cd14798    57 LKDWVKQVRDVAYDAEDIIDSFLLKLVPDKRRGGFLkrlfsllkELKELHQVAKEIQSIKSRIKDISS 124
Rx_N pfam18052
Rx N-terminal domain; This entry represents the N-terminal domain found in many plant ...
 8-47 4.98e-07

Rx N-terminal domain; This entry represents the N-terminal domain found in many plant resistance proteins. This domain has been predicted to be a coiled-coil, however the structure shows that it adopts a four helical bundle fold.


Pssm-ID: 436239  Cd Length: 93  Bit Score: 46.88  E-value: 4.98e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 2756267615   8 LKAWVEQVRDLSFDIEDCLAEFMVHVGSKSLSQQLMKLKH 47
Cdd:pfam18052  54 VKLWLKQLRDVAYDAEDVLDEFLYEALRRKSSPKKLKFRH 93
AAA_16 pfam13191
AAA ATPase domain; This family of domains contain a P-loop motif that is characteriztic of the ...
 101-225 2.11e-04

AAA ATPase domain; This family of domains contain a P-loop motif that is characteriztic of the AAA superfamily.


Pssm-ID: 433025 [Multi-domain]  Cd Length: 167  Bit Score: 41.34  E-value: 2.11e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2756267615 101 ELVGFDDAKESILNLIDvHANHGLAKVIFVVGMGGLGKTSLVKKVYHSIN----IVNNFSCRAWVTVSQsFVRTELLRGL 176
Cdd:pfam13191   1 RLVGREEELEQLLDALD-RVRSGRPPSVLLTGEAGTGKTTLLRELLRALErdggYFLRGKCDENLPYSP-LLEALTREGL 78

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2756267615 177 IKQLLGGDSENEH----------------FKGLQSMQRNEKVEDLVEDLKQGlkEKRYFVVLDDM 225
Cdd:pfam13191  79 LRQLLDELESSLLeawraallealapvpeLPGDLAERLLDLLLRLLDLLARG--ERPLVLVLDDL 141
NACHT pfam05729
NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in ...
 127-285 6.78e-03

NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in MHC transcription activation. This family is closely related to pfam00931.


Pssm-ID: 428606 [Multi-domain]  Cd Length: 166  Bit Score: 36.51  E-value: 6.78e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2756267615 127 VIFVVGMGGLGKTSLVKKV---------YHSINIVNNFSCRawvtvsqSFVRTELLRGLIKQL--LGGDSENEHFKGLQS 195
Cdd:pfam05729   2 TVILQGEAGSGKTTLLQKLallwaqgklPQGFDFVFFLPCR-------ELSRSGNARSLADLLfsQWPEPAAPVSEVWAV 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2756267615 196 MQRNEKVEDLVEDlkqGLKE-KRYFVVLDDMWSIDAL--NWLNESVFPdsnngGSRIIVTTRDA--SIIQNCAYPSYLYR 270
Cdd:pfam05729  75 ILELPERLLLILD---GLDElVSDLGQLDGPCPVLTLlsSLLRKKLLP-----GASLLLTVRPDalRDLRRGLEEPRYLE 146

                         170
                  ....*....|....*
gi 2756267615 271 LEPLKTDDAKQLLLR 285
Cdd:pfam05729 147 VRGFSESDRKQYVRK 161
RecA-like_Lon cd19500
lon protease homolog 2 peroxisomal; Lon protease (also known as Lon peptidase) is an ...
 94-150 9.53e-03

lon protease homolog 2 peroxisomal; Lon protease (also known as Lon peptidase) is an evolutionarily conserved ATP-dependent serine protease, present in bacteria and eukaryotic mitochondria and peroxisomes, which mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Lon protease is both an ATP-dependent peptidase and a protein-activated ATPase. This RecA-like Lon domain subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410908 [Multi-domain]  Cd Length: 182  Bit Score: 36.38  E-value: 9.53e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2756267615  94 AKNIDEAELVGFDDAKESILNLIDVHA--NHGLAKVIFVVGMGGLGKTSLVKKVYHSIN 150
Cdd:cd19500     4 ARKVLDADHYGLEDVKERILEYLAVRKlkGSMKGPILCLVGPPGVGKTSLGKSIARALG 62
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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