NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|86171918|ref|XP_966305|]
View 

erythrocyte membrane protein 1, PfEMP1 [Plasmodium falciparum 3D7]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
ATS pfam15445
acidic terminal segments, variant surface antigen of PfEMP1; ATS is the intracellular and ...
 3444-3954 0e+00

acidic terminal segments, variant surface antigen of PfEMP1; ATS is the intracellular and relatively conserved acidic terminal segment of the Plasmodium falciparum erythrocyte membrane protein-1 (PfEMP1). this domain appears to be present in all variants of the highly polymorphic PfEMP1 proteins.


:

Pssm-ID: 373851 [Multi-domain]  Cd Length: 446  Bit Score: 715.43  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86171918   3444 TIPFGVALALGSIAFLFLKKKTQAPV-DLFSVINIPKGDHDIPTLKSSNRYIPYVSDRYKGKTYIYMEGDSDSGH---YY 3519
Cdd:pfam15445    1 TIPWSVGIAFAAFTYFFLKKKTKSSVgNLFQILQIPKGDYDIPTLKSKNRYIPYASDRYKGKTYIYMEGDSSGDEkyaFM 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86171918   3520 EDTTDITSSESEYEELDINDIYPYKSPKYKTLIEVVLEPSGNNTPTsdtPSDTQNDIPSGDTP-NNKLTDNEWNTLKDEF 3598
Cdd:pfam15445   81 SDTTDITSSESEYEELDINDIYVPGSPKYKTLIEVVLEPSKNNTNT---PSDTQNDIPSDDIPsTNKITDEEWNTLKHDF 157

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86171918   3599 ISQYIQSEQpNDVPNDYTSGNSSTNTNITTTSRHNVEEKPFIMSIHDRNLYTGEEYNYD--MSTNSGNNDLYNGKNNLYS 3676
Cdd:pfam15445  158 ISNMLQNTQ-NDEPNILHSGNVPNNTHPNTLSRDNMEEKPFIMSIHDRNLYTGEEYSYNinMSTNSMDDIPKYVSNNVYS 236

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86171918   3677 GqnnvysgidptsdnrgpysdkndrisdnhhpysgIDLINDTLSGNAHIDIYDELLKRKENELFGTNHVKHTSTHSVAKH 3756
Cdd:pfam15445  237 G----------------------------------IDLINDTLSGNQHIDIYDEVLKRKENELFGTNHTKHTSTNSVAKN 282

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86171918   3757 TNSDPIHNQLNLFHTWLDRHRDMCEKWNTKEELLDKLNEQWNKDNNNSGNINPSgntpptsdipsgklSDIPSDNNihsd 3836
Cdd:pfam15445  283 TNSDPILNQLNLFHKWLDRHRDMCEKWKNKEERLDKLKEEWNKENNHSGDIHPS--------------DDIPSDNK---- 344

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86171918   3837 ipyVLNTDVSIQIDMNNPKTTNEFtyvdsnpnqvddTYVDSNPDNSSMDTILEDLDKpFNEPyYYDMYDDDIYYDVHDHD 3916
Cdd:pfam15445  345 ---VLNTDVSIQIDMDNPKPKNEF------------TNMDTNPDNSTMDTILDDLEK-YNEP-YYDIYEDDIYYDVNDHD 407

                          490       500       510
                   ....*....|....*....|....*....|....*....
gi 86171918   3917 TSTVDTNAMDVPSKVQIEMDVNT-KLVKEKYPISDVWDI 3954
Cdd:pfam15445  408 ASTVDSNNMDVPSKVQIEMDVNNtKLVEEKYPISDVWNI 446
PTZ00176 super family cl31413
erythrocyte membrane protein 1 (PfEMP1); Provisional
 2817-3954 0e+00

erythrocyte membrane protein 1 (PfEMP1); Provisional


The actual alignment was detected with superfamily member PTZ00176:

Pssm-ID: 140204 [Multi-domain]  Cd Length: 1317  Bit Score: 611.27  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86171918  2817 IPPRRRHLCLRNIIIKKNYRKGDISKFKDDLFYAAASEAKFLFNNYENKNES--LQAIKYTFADIGDIIKGNDMMDDMTY 2894
Cdd:PTZ00176  123 APFRRQNMCDKNLEYLINKNTENTHDLLGNVLVTAKYEGESIVNNHPDKDKSsvCTALARSFADIGDIVRGKDMFKRNKH 202

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86171918  2895 KKIKGKLEKVL------------------DKTGNNPETPEKWWEQNKKHVWEAMLC---------GYKLAGGEIKP---- 2943
Cdd:PTZ00176  203 DNVENGLREVFkkiyeglknngarehykeVKNGNYIKLREDWWTANRDQVWKAMTCvapenayfrKTEADGIGISSlilp 282

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86171918  2944 -----NDCNIPTEESTHQFLRWLTEWGTQYCKekqqlKLNMQIPCMTHFDKYGIIENRIDVHP---NCLQGLGKYEI--- 3012
Cdd:PTZ00176  283 yskcgRDTDPPVVDYIPQRLRWMSEWSEYFCN-----VLNKEIDEMNNQCKDCEMSRRCNNDTegeKCKKCKEQCQIfke 357

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86171918  3013 ----WSNnripDWERLSSKFNEVKGTMNENVKKLTA---------------YE-------YLKQNCSKCICSFKDIEQTH 3066
Cdd:PTZ00176  358 lvskWKN----QFDKQSMKYMELYNKASTNITKQNSsapergyrrnhrrrgYDddtnvqlFLKKVIENNECKVESLGKYL 433

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86171918  3067 KKSKDEG-YHIYEDILDKAQIPSFLEDTAYRYKGL------NP--ECPEDIE---CSQYGNI-PCRGVSHDDD-NDWNSS 3132
Cdd:PTZ00176  434 DKTSHCGnYNFNYDNTPGSNRSNAFEITPEKFKKAckckipNPleKCPNEENknvCTRFDKVySCTSLSFKNDlSEWNNS 513

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86171918  3133 FVKDNKTTNLGVLVPPRRRHLCLRIDVNKFLRLRnDINNLKTFICKSAFAEAKRLKKVYKDDNSKLHQAMKYSFSDIGSV 3212
Cdd:PTZ00176  514 GVKNKENDNNGVLVPPRRRNLCINLFSKKDYKMK-DENDFKEDLLNAAFSQGKLLGKKYSNYSNEAYEAMKFSYADYSDI 592

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86171918  3213 VKGNDMMESPTSDNiAKIFRGMKYTE-----INRETWWDLNKYHVWESMLCGYR-EAGGDTKKSENCRFPDIERVPQFLR 3286
Cdd:PTZ00176  593 VKGTDMMNDLKKLN-KELNTLLKETEkgdisVDRKTWWDDNKNVVWNAMLCGYKtENENQQLNSSWCNVPDDDNIDQFLR 671

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86171918  3287 WFQEWTEIFCIKRKTLYDKMVTECQ---KAECDTSNGTVKETKCTKAC---EEYKSYVLSKKK---EYYIQKDKYDNQFK 3357
Cdd:PTZ00176  672 WLTEWAQQYCKEKLIKAHIINTKCKdivEGRKHKSMVDITDVECKRLFidyEEWFRYRYNQWKglsEKYIKIKKSKNSGV 751

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86171918  3358 KVLNNKDAEEFLNVHC-------------------LSEYFK--------DETRWKNPYESIADKALKGKCDCKKMIPTTP 3410
Cdd:PTZ00176  752 NIPSEECAASYVTKHCngcicnlrdmedihkninnQNELMKeminiikfDTDQYRTQLQNISNSMEINPKSVKTAVDTTK 831

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86171918  3411 EV-----------------------KPKKPAVPEAKKPeVEPLPSDEPFNRDILEK---TIP--FGVALALGSIAFLfLK 3462
Cdd:PTZ00176  832 DIvsyglagtmgvaaiglqagdflgKKIQDLYNEFMKP-VEKKLDTSSKNLNIYEDpniMVPagIGVALTLGLLLFK-MR 909

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86171918  3463 KKTQAPVDLFSVINIPKGDHDIPTLKSSNRYIPYVSDRYKGKTYIYMEGDSDSGHYY--EDTTDITSSESEYEELDINDI 3540
Cdd:PTZ00176  910 RKAKRQVDMIRILQMSQNEYGIPTTKSPNKYVPYGSQRYKGKTYLYVEGDTDEEKYMfmSDTTDITSSESEYEEMDINDI 989

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86171918  3541 YPYKSPKYKTLIEVVLEPSgnntptsdtPSDTQNDIPSGDTPNNKLTDNEWNTLKDEFISQYIQSEQPNdvpNDYTSGNS 3620
Cdd:PTZ00176  990 YVPGSPKYKTLIEVVLEPS---------KRDTQNDIPSDNTPSYKLTDEEWNQLKDDFISQYLPNTEPN---NNYRSGNS 1057

                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86171918  3621 STNTNITTTSRHNVEEKPFIMSIHDRNLYTGEE--YNYDMSTNSGNNDLYNgknnlysgQNNVYSGIDptsdnrgpysdk 3698
Cdd:PTZ00176 1058 PTNTNNTTTSHDNMGEKPFIMSIHDRNLYTGEEisYNINMSTNTMDDPKYV--------SNNVYSGID------------ 1117

                        1050      1060      1070      1080      1090      1100      1110      1120
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86171918  3699 ndrisdnhhpysgidLINDTLSGNAHIDIYDELLKRKENELFGTNHVKHTSTHSVAKHT-NSDPIHNQLNLFHTWLDRHR 3777
Cdd:PTZ00176 1118 ---------------LINDTLSGNQHIDIYDEVLKRKENELFGTNHVKQTSIHSVAKNTySDDAITNKINLFHKWLDRHR 1182

                        1130      1140      1150      1160      1170      1180      1190      1200
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86171918  3778 DMCEKWNTKEELLDKLNEQWNKDNNNsgninpsgntpptsdipsgklSDIPSDNnihsdipYVLNTDVSIQIDMNNPKTT 3857
Cdd:PTZ00176 1183 DMCEKWENHHERLAKLKEKWENDNDG---------------------GNVPSDN-------HVLNTDVSIEIDMDNPKPI 1234

                        1210      1220      1230      1240      1250      1260      1270      1280
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86171918  3858 NEFTYVDSNP------NQVDDTYVDSNpDNSsmdtilEDLDKPfnepyyydmydddiYYDVHDHDTSTVDtnaMDVPSKV 3931
Cdd:PTZ00176 1235 NQFSNMDINVdtptmdNMEDDIYYDVN-DND------DDNDQP--------------SVYDIPMDHNKVD---VDVPKKV 1290

                        1290      1300
                  ....*....|....*....|....*..
gi 86171918  3932 QIEMDV--NTK--LVKEKYPISDVWDI 3954
Cdd:PTZ00176 1291 HIEMKIlnNTSngSLEQQFPISDVWNI 1317
Duffy_binding pfam05424
Duffy binding domain; This domain is found in Plasmodium Duffy binding proteins. Plasmodium ...
 116-310 1.20e-85

Duffy binding domain; This domain is found in Plasmodium Duffy binding proteins. Plasmodium vivax and Plasmodium knowlesi merozoites invade human erythrocytes that express Duffy blood group surface determinants. The Duffy receptor family is localized in micronemes, an organelle found in all organizms of the phylum Apicomplexa. This family is closely associated on PfEMP1 proteins with PFEMP, pfam03011.


:

Pssm-ID: 428465 [Multi-domain]  Cd Length: 178  Bit Score: 278.39  E-value: 1.20e-85
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86171918    116 CAPYRRLHLCVQNLEQIKPDQITSTHNLLVDVLLAAKYEGQSITQDYPKYQATYDDSPSKMCTMLARSFADIGDIVRGKD 195
Cdd:pfam05424    2 CAPPRRLHLCVKNLEKINSGNTTTTHDLLKAVILAAKYEGFSLWHKYKKKNTKYGDIPSEFCRQMAYSFADIGDIIRGKD 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86171918    196 LFLGTNEEKKpLEENLKEIFKKIYENLgiqeKNHYNDTPDYYKLREDWWIANRDQVWKAITCNAG-GYSYFRKTCGGDNE 274
Cdd:pfam05424   82 LYLGNNKKKK-LEENLKKIFKKIYEKL----TSKGKDDGNYYQLREDWWEANREDIWKAMTCALTyGAKYFRKTCGDGIS 156

                          170       180       190
                   ....*....|....*....|....*....|....*.
gi 86171918    275 KNSTlasnkcrckdekgeHDTDQVPTYFDYVPQYLR 310
Cdd:pfam05424  157 PSTA--------------GCNDDVPTYFDYVPQFLR 178
PTZ00176 super family cl31413
erythrocyte membrane protein 1 (PfEMP1); Provisional
 15-419 1.18e-70

erythrocyte membrane protein 1 (PfEMP1); Provisional


The actual alignment was detected with superfamily member PTZ00176:

Pssm-ID: 140204 [Multi-domain]  Cd Length: 1317  Bit Score: 263.82  E-value: 1.18e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86171918    15 SVKDLFDRIGKEVHDQVEKEANqYKEALKGDLSSATFPTGRRH-----EKPQSESCKLNYIYDTNVTSG-GGKENPCYGR 88
Cdd:PTZ00176   14 SARNVLENIGNEIKDKRENESK-YTDKLKGSLWEARFSDGLSSsfgdvRSGYYDSCSLDHKFHTNINNGyPPARNPCDGR 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86171918    89 QGVRFSDTKGAKCYSYKIE--DNDSSIGFCAPYRRLHLCVQNLEQIKPDQITSTHNLLVDVLLAAKYEGQSITQDYPkyq 166
Cdd:PTZ00176   93 NQNRFDENGESYCNSDKIRgnENNSNAGACAPFRRQNMCDKNLEYLINKNTENTHDLLGNVLVTAKYEGESIVNNHP--- 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86171918   167 atyDDSPSKMCTMLARSFADIGDIVRGKDLFLGTNEEKkpLEENLKEIFKKIYENLGIQE-KNHYND--TPDYYKLREDW 243
Cdd:PTZ00176  170 ---DKDKSSVCTALARSFADIGDIVRGKDMFKRNKHDN--VENGLREVFKKIYEGLKNNGaREHYKEvkNGNYIKLREDW 244

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86171918   244 WIANRDQVWKAITCNAGGYSYFRKT-CGGDNEKNSTLASNKCrckdekgEHDTDqvPTYFDYVPQYLRWFEEWAEDFCRK 322
Cdd:PTZ00176  245 WTANRDQVWKAMTCVAPENAYFRKTeADGIGISSLILPYSKC-------GRDTD--PPVVDYIPQRLRWMSEWSEYFCNV 315

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86171918   323 KKIKVENVKKSCRgedkeskdrycsrngyDCEKTKRAIGKLRyGKQCISCLYGCNPYVDWIEKQKEQFDKQKKIYdkeiK 402
Cdd:PTZ00176  316 LNKEIDEMNNQCK----------------DCEMSRRCNNDTE-GEKCKKCKEQCQIFKELVSKWKNQFDKQSMKY----M 374

                         410
                  ....*....|....*..
gi 86171918   403 KYENGASSSSRKTRAAS 419
Cdd:PTZ00176  375 ELYNKASTNITKQNSSA 391
PTZ00176 super family cl31413
erythrocyte membrane protein 1 (PfEMP1); Provisional
 907-1601 4.74e-66

erythrocyte membrane protein 1 (PfEMP1); Provisional


The actual alignment was detected with superfamily member PTZ00176:

Pssm-ID: 140204 [Multi-domain]  Cd Length: 1317  Bit Score: 249.18  E-value: 4.74e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86171918   907 EPCKGKdgNNERFKIGTEWKIG-EKVETSYKD----VFLPPRRQHMCTSNLENLdvdsVTENDKASHSLLGDVQLAAKTD 981
Cdd:PTZ00176   87 NPCDGR--NQNRFDENGESYCNsDKIRGNENNsnagACAPFRRQNMCDKNLEYL----INKNTENTHDLLGNVLVTAKYE 160

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86171918   982 AAEIIKRYKDqnniqltdpiqqKDQEAMCRAIRYSFADLGDIIRGRDMWnKDSGSTEMEKHLISIFEKINEKLPE---KE 1058
Cdd:PTZ00176  161 GESIVNNHPD------------KDKSSVCTALARSFADIGDIVRGKDMF-KRNKHDNVENGLREVFKKIYEGLKNngaRE 227

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86171918  1059 QKKYSNDGKYLDLRKDWWEANRYKVWKAMKC-ATKNS---KIPCSGI------------------PIEDYIPQRLRWMTE 1116
Cdd:PTZ00176  228 HYKEVKNGNYIKLREDWWTANRDQVWKAMTCvAPENAyfrKTEADGIgisslilpyskcgrdtdpPVVDYIPQRLRWMSE 307

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86171918  1117 WAEWFCKEQSQAYETLQDQCGKCTGPNKDNCTRDNNDCNTCTKACEEYEQKIKKWADQWKVISKKYEELYLQAKTAFART 1196
Cdd:PTZ00176  308 WSEYFCNVLNKEIDEMNNQCKDCEMSRRCNNDTEGEKCKKCKEQCQIFKELVSKWKNQFDKQSMKYMELYNKASTNITKQ 387

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86171918  1197 AFPDDDPDYQQvveffkelqkeinrsaSQRSKRSIDVTNTDPtltspyssaagYIHQEIGNVGCNVQ--------TQFCE 1268
Cdd:PTZ00176  388 NSSAPERGYRR----------------NHRRRGYDDDTNVQL-----------FLKKVIENNECKVEslgkyldkTSHCG 440

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86171918  1269 KKNGVIPTTgSGTNNKNyAFKNTPKDHDEACECESRPQVPPKKKEDEEDVCEKVKgllkgkdgettEINGCKP---KGNG 1345
Cdd:PTZ00176  441 NYNFNYDNT-PGSNRSN-AFEITPEKFKKACKCKIPNPLEKCPNEENKNVCTRFD-----------KVYSCTSlsfKNDL 507

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86171918  1346 NTWNCS---NQIDDSHkGACMPPRRQSLCIhNL--KESNETGTEQQLREAFINCAAIETFWLWYKYKKDKNvdaekkleq 1420
Cdd:PTZ00176  508 SEWNNSgvkNKENDNN-GVLVPPRRRNLCI-NLfsKKDYKMKDENDFKEDLLNAAFSQGKLLGKKYSNYSN--------- 576

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86171918  1421 geipsEFLRSMIYTFGDYRDLCLNTDIsakkdpikivKNNIQKVFNRNNGPHKEGDKEK----RKKFWETNKNDIWQGML 1496
Cdd:PTZ00176  577 -----EAYEAMKFSYADYSDIVKGTDM----------MNDLKKLNKELNTLLKETEKGDisvdRKTWWDDNKNVVWNAML 641

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86171918  1497 CALeKIANNKKTLTETYnyslvkfsgnnsTTLEDFAKTPQFLRWFTEWGDDFCqqqKEQLVtlQEACPNGICEQSEEEKK 1576
Cdd:PTZ00176  642 CGY-KTENENQQLNSSW------------CNVPDDDNIDQFLRWLTEWAQQYC---KEKLI--KAHIINTKCKDIVEGRK 703

                         730       740       750
                  ....*....|....*....|....*....|....*....
gi 86171918  1577 ----------KCKSACEKYQAFIE----KWKGYYDKQSK 1601
Cdd:PTZ00176  704 hksmvditdvECKRLFIDYEEWFRyrynQWKGLSEKYIK 742
PTZ00176 super family cl31413
erythrocyte membrane protein 1 (PfEMP1); Provisional
 2536-3067 1.24e-55

erythrocyte membrane protein 1 (PfEMP1); Provisional


The actual alignment was detected with superfamily member PTZ00176:

Pssm-ID: 140204 [Multi-domain]  Cd Length: 1317  Bit Score: 215.67  E-value: 1.24e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86171918  2536 AMERSYADYGTIVKEDILWDYEDKKKIDPKIMN-FAKNHNISTTKTIVSSLDDDD----VK-RQKLWESIRIDVWKAMIC 2609
Cdd:PTZ00176  179 ALARSFADIGDIVRGKDMFKRNKHDNVENGLREvFKKIYEGLKNNGAREHYKEVKngnyIKlREDWWTANRDQVWKAMTC 258

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86171918  2610 -----GY---KDAIGGDMNSLPNDVDLC----TLPTTDDEYSFLRWFVEWGQNFCIRHEKELKQLNEEC-----ARGTCD 2672
Cdd:PTZ00176  259 vapenAYfrkTEADGIGISSLILPYSKCgrdtDPPVVDYIPQRLRWMSEWSEYFCNVLNKEIDEMNNQCkdcemSRRCNN 338

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86171918  2673 GTDEEKKKKCEKACKNYREFLNNFKKQYENQKKEY---------EIIK--SSYPK-----------YEKKDAFTFLKDKC 2730
Cdd:PTZ00176  339 DTEGEKCKKCKEQCQIFKELVSKWKNQFDKQSMKYmelynkastNITKqnSSAPErgyrrnhrrrgYDDDTNVQLFLKKV 418

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86171918  2731 NSNYSC---------------------FENKTEISVLKMFEHPPDDVKDECDCKTSKAHDDKVNDLDKCPNNINNNKNIc 2789
Cdd:PTZ00176  419 IENNECkveslgkyldktshcgnynfnYDNTPGSNRSNAFEITPEKFKKACKCKIPNPLEKCPNEENKNVCTRFDKVYS- 497

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86171918  2790 nkykkrriCGDLKYSNSLDHWFGTNT----------LIPPRRRHLCLrNIIIKKNYRKGDISKFKDDLFYAAASEAKFLF 2859
Cdd:PTZ00176  498 --------CTSLSFKNDLSEWNNSGVknkendnngvLVPPRRRNLCI-NLFSKKDYKMKDENDFKEDLLNAAFSQGKLLG 568

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86171918  2860 NNYEN-KNESLQAIKYTFADIGDIIKGNDMMDDMtyKKIKGKLEKVLDKT--GNNPETPEKWWEQNKKHVWEAMLCGYKL 2936
Cdd:PTZ00176  569 KKYSNySNEAYEAMKFSYADYSDIVKGTDMMNDL--KKLNKELNTLLKETekGDISVDRKTWWDDNKNVVWNAMLCGYKT 646

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86171918  2937 AGGEIKPND--CNIPTEESTHQFLRWLTEWGTQYCKEK--QQLKLNMQIPCMTHFDKYGIIENRIDVHpnCLQGLGKYEI 3012
Cdd:PTZ00176  647 ENENQQLNSswCNVPDDDNIDQFLRWLTEWAQQYCKEKliKAHIINTKCKDIVEGRKHKSMVDITDVE--CKRLFIDYEE 724

                         570       580       590       600       610
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 86171918  3013 WSNNRIPDWERLSSKFNEVKGTMNENV---KKLTAYEYLKQNCSKCICSFKDIEQTHK 3067
Cdd:PTZ00176  725 WFRYRYNQWKGLSEKYIKIKKSKNSGVnipSEECAASYVTKHCNGCICNLRDMEDIHK 782
Duffy_binding pfam05424
Duffy binding domain; This domain is found in Plasmodium Duffy binding proteins. Plasmodium ...
 1762-1940 2.01e-35

Duffy binding domain; This domain is found in Plasmodium Duffy binding proteins. Plasmodium vivax and Plasmodium knowlesi merozoites invade human erythrocytes that express Duffy blood group surface determinants. The Duffy receptor family is localized in micronemes, an organelle found in all organizms of the phylum Apicomplexa. This family is closely associated on PfEMP1 proteins with PFEMP, pfam03011.


:

Pssm-ID: 428465 [Multi-domain]  Cd Length: 178  Bit Score: 134.71  E-value: 2.01e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86171918   1762 CIPPRRQQMYIQPLQSLSGNE--SQVELRRIFIEMAAIETFFQWHKFKKekvreikekdeidgkislfgqddtsieenlq 1839
Cdd:pfam05424    2 CAPPRRLHLCVKNLEKINSGNttTTHDLLKAVILAAKYEGFSLWHKYKK------------------------------- 50

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86171918   1840 KQLKNGTIPDDFKRQMFYTFGDYKDILFGK--YIG-IDMGTVKTNIGRVFNNGGNK----------SDEEREKWWKNHGP 1906
Cdd:pfam05424   51 KNTKYGDIPSEFCRQMAYSFADIGDIIRGKdlYLGnNKKKKLEENLKKIFKKIYEKltskgkddgnYYQLREDWWEANRE 130

                          170       180       190
                   ....*....|....*....|....*....|....
gi 86171918   1907 SIWNGMLCGLSYDTKTKHNIQGVYTQLTDPSKNN 1940
Cdd:pfam05424  131 DIWKAMTCALTYGAKYFRKTCGDGISPSTAGCND 164
PFEMP super family cl03834
PFEMP1 DBL domain; PfEMP1 (Plasmodium falciparum erythrocyte membrane protein) has been ...
 652-811 1.05e-30

PFEMP1 DBL domain; PfEMP1 (Plasmodium falciparum erythrocyte membrane protein) has been identified as the rosetting ligand of the malaria parasite P. falciparum. Rosetting is the adhesion of infected erythrocytes with uninfected erythrocytes in the vasculature of the infected organ, and is associated with severe malaria. PfEMP1 interacts with Complement Receptor One on uninfected erythrocytes to form rosettes. The extreme variation within these proteins and the grouping of var genes implies that var gene recombination preferentially occurs within var gene groups. These groups reflect a functional diversification that has evolved to cope with the varying conditions of transmission and host immune response met by the parasite. A recombination hotspot was uncovered between Duffy-binding-like (DBL) subdomains. Solution of the crystal structure of the N-terminal and first DBL region of PfEMP1 from the VarO variant of the PfEMP1 protein is found to be directly implicated in rosetting as the heparin-binding site.


The actual alignment was detected with superfamily member pfam03011:

Pssm-ID: 281064  Cd Length: 154  Bit Score: 120.29  E-value: 1.05e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86171918    652 FFYYWVAHMLKDSIHWKKKLQRCLEKKNGNTCKKnNCKDNCGCFEKWVAQKKEqEWDPIKQQFRKQDFGKqELILGQIRY 731
Cdd:pfam03011    1 LFKRWVEYFLEDSIKWRKKLKSCINNGKGKCCKK-ECKNDCECFKKWVEKKKE-EWKKIKEHFLKQYKLK-GLTGKTLDE 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86171918    732 DYVLDELLKKDELLTSIKEGYGDANEIKHIKALLEDEENEETQEEetaGADNQKKNTIDWLIQHEEDDAELCLEIHEDEE 811
Cdd:pfam03011   78 YLDLKSFLETFLFYIDIKEAYGDVKELKKLEEILDEEGCSAGAES---AKNNKNEDAIDKLLDKEEKKANNCKEKHKEND 154
PFEMP super family cl03834
PFEMP1 DBL domain; PfEMP1 (Plasmodium falciparum erythrocyte membrane protein) has been ...
 2223-2367 1.70e-21

PFEMP1 DBL domain; PfEMP1 (Plasmodium falciparum erythrocyte membrane protein) has been identified as the rosetting ligand of the malaria parasite P. falciparum. Rosetting is the adhesion of infected erythrocytes with uninfected erythrocytes in the vasculature of the infected organ, and is associated with severe malaria. PfEMP1 interacts with Complement Receptor One on uninfected erythrocytes to form rosettes. The extreme variation within these proteins and the grouping of var genes implies that var gene recombination preferentially occurs within var gene groups. These groups reflect a functional diversification that has evolved to cope with the varying conditions of transmission and host immune response met by the parasite. A recombination hotspot was uncovered between Duffy-binding-like (DBL) subdomains. Solution of the crystal structure of the N-terminal and first DBL region of PfEMP1 from the VarO variant of the PfEMP1 protein is found to be directly implicated in rosetting as the heparin-binding site.


The actual alignment was detected with superfamily member pfam03011:

Pssm-ID: 281064  Cd Length: 154  Bit Score: 93.72  E-value: 1.70e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86171918   2223 LFHRWITDFIQYYNKSKEKIKPCTNDVN--SCKQGCKGNCDCVDKWLKNKSTEWEIIKKYYKENFGNTNEHIAYA----- 2295
Cdd:pfam03011    1 LFKRWVEYFLEDSIKWRKKLKSCINNGKgkCCKKECKNDCECFKKWVEKKKEEWKKIKEHFLKQYKLKGLTGKTLdeyld 80

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 86171918   2296 IKIFLQEGLFDSDYKRAQEVIDQ-NEWEQLWGCTGDNLKDVkdqKAENCNKGDFITNLISKLQDKITSCQNKH 2367
Cdd:pfam03011   81 LKSFLETFLFYIDIKEAYGDVKElKKLEEILDEEGCSAGAE---SAKNNKNEDAIDKLLDKEEKKANNCKEKH 150
PTZ00176 super family cl31413
erythrocyte membrane protein 1 (PfEMP1); Provisional
 1897-2072 1.03e-07

erythrocyte membrane protein 1 (PfEMP1); Provisional


The actual alignment was detected with superfamily member PTZ00176:

Pssm-ID: 140204 [Multi-domain]  Cd Length: 1317  Bit Score: 58.51  E-value: 1.03e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86171918  1897 REKWWKNHGPSIWNGMLCGL---SYDTKTKHNIQGVYTQLTDPSKNNmyekvtfpSKTGPSVNTKLeqfarrPTYFRWLE 1973
Cdd:PTZ00176  241 REDWWTANRDQVWKAMTCVApenAYFRKTEADGIGISSLILPYSKCG--------RDTDPPVVDYI------PQRLRWMS 306

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86171918  1974 EWGEEFCKKRTDKLKKLEKECRGVNYSgynKYCSgdgyhcDDEKGTynsinanlNCRDCMKECRNYKTWIVKKKNEYDKQ 2053
Cdd:PTZ00176  307 EWSEYFCNVLNKEIDEMNNQCKDCEMS---RRCN------NDTEGE--------KCKKCKEQCQIFKELVSKWKNQFDKQ 369

                         170
                  ....*....|....*....
gi 86171918  2054 KSKYVNEHENVISFLNKQS 2072
Cdd:PTZ00176  370 SMKYMELYNKASTNITKQN 388
 
Name Accession Description Interval E-value
ATS pfam15445
acidic terminal segments, variant surface antigen of PfEMP1; ATS is the intracellular and ...
 3444-3954 0e+00

acidic terminal segments, variant surface antigen of PfEMP1; ATS is the intracellular and relatively conserved acidic terminal segment of the Plasmodium falciparum erythrocyte membrane protein-1 (PfEMP1). this domain appears to be present in all variants of the highly polymorphic PfEMP1 proteins.


Pssm-ID: 373851 [Multi-domain]  Cd Length: 446  Bit Score: 715.43  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86171918   3444 TIPFGVALALGSIAFLFLKKKTQAPV-DLFSVINIPKGDHDIPTLKSSNRYIPYVSDRYKGKTYIYMEGDSDSGH---YY 3519
Cdd:pfam15445    1 TIPWSVGIAFAAFTYFFLKKKTKSSVgNLFQILQIPKGDYDIPTLKSKNRYIPYASDRYKGKTYIYMEGDSSGDEkyaFM 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86171918   3520 EDTTDITSSESEYEELDINDIYPYKSPKYKTLIEVVLEPSGNNTPTsdtPSDTQNDIPSGDTP-NNKLTDNEWNTLKDEF 3598
Cdd:pfam15445   81 SDTTDITSSESEYEELDINDIYVPGSPKYKTLIEVVLEPSKNNTNT---PSDTQNDIPSDDIPsTNKITDEEWNTLKHDF 157

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86171918   3599 ISQYIQSEQpNDVPNDYTSGNSSTNTNITTTSRHNVEEKPFIMSIHDRNLYTGEEYNYD--MSTNSGNNDLYNGKNNLYS 3676
Cdd:pfam15445  158 ISNMLQNTQ-NDEPNILHSGNVPNNTHPNTLSRDNMEEKPFIMSIHDRNLYTGEEYSYNinMSTNSMDDIPKYVSNNVYS 236

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86171918   3677 GqnnvysgidptsdnrgpysdkndrisdnhhpysgIDLINDTLSGNAHIDIYDELLKRKENELFGTNHVKHTSTHSVAKH 3756
Cdd:pfam15445  237 G----------------------------------IDLINDTLSGNQHIDIYDEVLKRKENELFGTNHTKHTSTNSVAKN 282

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86171918   3757 TNSDPIHNQLNLFHTWLDRHRDMCEKWNTKEELLDKLNEQWNKDNNNSGNINPSgntpptsdipsgklSDIPSDNNihsd 3836
Cdd:pfam15445  283 TNSDPILNQLNLFHKWLDRHRDMCEKWKNKEERLDKLKEEWNKENNHSGDIHPS--------------DDIPSDNK---- 344

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86171918   3837 ipyVLNTDVSIQIDMNNPKTTNEFtyvdsnpnqvddTYVDSNPDNSSMDTILEDLDKpFNEPyYYDMYDDDIYYDVHDHD 3916
Cdd:pfam15445  345 ---VLNTDVSIQIDMDNPKPKNEF------------TNMDTNPDNSTMDTILDDLEK-YNEP-YYDIYEDDIYYDVNDHD 407

                          490       500       510
                   ....*....|....*....|....*....|....*....
gi 86171918   3917 TSTVDTNAMDVPSKVQIEMDVNT-KLVKEKYPISDVWDI 3954
Cdd:pfam15445  408 ASTVDSNNMDVPSKVQIEMDVNNtKLVEEKYPISDVWNI 446
PTZ00176 PTZ00176
erythrocyte membrane protein 1 (PfEMP1); Provisional
 2817-3954 0e+00

erythrocyte membrane protein 1 (PfEMP1); Provisional


Pssm-ID: 140204 [Multi-domain]  Cd Length: 1317  Bit Score: 611.27  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86171918  2817 IPPRRRHLCLRNIIIKKNYRKGDISKFKDDLFYAAASEAKFLFNNYENKNES--LQAIKYTFADIGDIIKGNDMMDDMTY 2894
Cdd:PTZ00176  123 APFRRQNMCDKNLEYLINKNTENTHDLLGNVLVTAKYEGESIVNNHPDKDKSsvCTALARSFADIGDIVRGKDMFKRNKH 202

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86171918  2895 KKIKGKLEKVL------------------DKTGNNPETPEKWWEQNKKHVWEAMLC---------GYKLAGGEIKP---- 2943
Cdd:PTZ00176  203 DNVENGLREVFkkiyeglknngarehykeVKNGNYIKLREDWWTANRDQVWKAMTCvapenayfrKTEADGIGISSlilp 282

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86171918  2944 -----NDCNIPTEESTHQFLRWLTEWGTQYCKekqqlKLNMQIPCMTHFDKYGIIENRIDVHP---NCLQGLGKYEI--- 3012
Cdd:PTZ00176  283 yskcgRDTDPPVVDYIPQRLRWMSEWSEYFCN-----VLNKEIDEMNNQCKDCEMSRRCNNDTegeKCKKCKEQCQIfke 357

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86171918  3013 ----WSNnripDWERLSSKFNEVKGTMNENVKKLTA---------------YE-------YLKQNCSKCICSFKDIEQTH 3066
Cdd:PTZ00176  358 lvskWKN----QFDKQSMKYMELYNKASTNITKQNSsapergyrrnhrrrgYDddtnvqlFLKKVIENNECKVESLGKYL 433

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86171918  3067 KKSKDEG-YHIYEDILDKAQIPSFLEDTAYRYKGL------NP--ECPEDIE---CSQYGNI-PCRGVSHDDD-NDWNSS 3132
Cdd:PTZ00176  434 DKTSHCGnYNFNYDNTPGSNRSNAFEITPEKFKKAckckipNPleKCPNEENknvCTRFDKVySCTSLSFKNDlSEWNNS 513

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86171918  3133 FVKDNKTTNLGVLVPPRRRHLCLRIDVNKFLRLRnDINNLKTFICKSAFAEAKRLKKVYKDDNSKLHQAMKYSFSDIGSV 3212
Cdd:PTZ00176  514 GVKNKENDNNGVLVPPRRRNLCINLFSKKDYKMK-DENDFKEDLLNAAFSQGKLLGKKYSNYSNEAYEAMKFSYADYSDI 592

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86171918  3213 VKGNDMMESPTSDNiAKIFRGMKYTE-----INRETWWDLNKYHVWESMLCGYR-EAGGDTKKSENCRFPDIERVPQFLR 3286
Cdd:PTZ00176  593 VKGTDMMNDLKKLN-KELNTLLKETEkgdisVDRKTWWDDNKNVVWNAMLCGYKtENENQQLNSSWCNVPDDDNIDQFLR 671

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86171918  3287 WFQEWTEIFCIKRKTLYDKMVTECQ---KAECDTSNGTVKETKCTKAC---EEYKSYVLSKKK---EYYIQKDKYDNQFK 3357
Cdd:PTZ00176  672 WLTEWAQQYCKEKLIKAHIINTKCKdivEGRKHKSMVDITDVECKRLFidyEEWFRYRYNQWKglsEKYIKIKKSKNSGV 751

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86171918  3358 KVLNNKDAEEFLNVHC-------------------LSEYFK--------DETRWKNPYESIADKALKGKCDCKKMIPTTP 3410
Cdd:PTZ00176  752 NIPSEECAASYVTKHCngcicnlrdmedihkninnQNELMKeminiikfDTDQYRTQLQNISNSMEINPKSVKTAVDTTK 831

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86171918  3411 EV-----------------------KPKKPAVPEAKKPeVEPLPSDEPFNRDILEK---TIP--FGVALALGSIAFLfLK 3462
Cdd:PTZ00176  832 DIvsyglagtmgvaaiglqagdflgKKIQDLYNEFMKP-VEKKLDTSSKNLNIYEDpniMVPagIGVALTLGLLLFK-MR 909

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86171918  3463 KKTQAPVDLFSVINIPKGDHDIPTLKSSNRYIPYVSDRYKGKTYIYMEGDSDSGHYY--EDTTDITSSESEYEELDINDI 3540
Cdd:PTZ00176  910 RKAKRQVDMIRILQMSQNEYGIPTTKSPNKYVPYGSQRYKGKTYLYVEGDTDEEKYMfmSDTTDITSSESEYEEMDINDI 989

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86171918  3541 YPYKSPKYKTLIEVVLEPSgnntptsdtPSDTQNDIPSGDTPNNKLTDNEWNTLKDEFISQYIQSEQPNdvpNDYTSGNS 3620
Cdd:PTZ00176  990 YVPGSPKYKTLIEVVLEPS---------KRDTQNDIPSDNTPSYKLTDEEWNQLKDDFISQYLPNTEPN---NNYRSGNS 1057

                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86171918  3621 STNTNITTTSRHNVEEKPFIMSIHDRNLYTGEE--YNYDMSTNSGNNDLYNgknnlysgQNNVYSGIDptsdnrgpysdk 3698
Cdd:PTZ00176 1058 PTNTNNTTTSHDNMGEKPFIMSIHDRNLYTGEEisYNINMSTNTMDDPKYV--------SNNVYSGID------------ 1117

                        1050      1060      1070      1080      1090      1100      1110      1120
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86171918  3699 ndrisdnhhpysgidLINDTLSGNAHIDIYDELLKRKENELFGTNHVKHTSTHSVAKHT-NSDPIHNQLNLFHTWLDRHR 3777
Cdd:PTZ00176 1118 ---------------LINDTLSGNQHIDIYDEVLKRKENELFGTNHVKQTSIHSVAKNTySDDAITNKINLFHKWLDRHR 1182

                        1130      1140      1150      1160      1170      1180      1190      1200
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86171918  3778 DMCEKWNTKEELLDKLNEQWNKDNNNsgninpsgntpptsdipsgklSDIPSDNnihsdipYVLNTDVSIQIDMNNPKTT 3857
Cdd:PTZ00176 1183 DMCEKWENHHERLAKLKEKWENDNDG---------------------GNVPSDN-------HVLNTDVSIEIDMDNPKPI 1234

                        1210      1220      1230      1240      1250      1260      1270      1280
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86171918  3858 NEFTYVDSNP------NQVDDTYVDSNpDNSsmdtilEDLDKPfnepyyydmydddiYYDVHDHDTSTVDtnaMDVPSKV 3931
Cdd:PTZ00176 1235 NQFSNMDINVdtptmdNMEDDIYYDVN-DND------DDNDQP--------------SVYDIPMDHNKVD---VDVPKKV 1290

                        1290      1300
                  ....*....|....*....|....*..
gi 86171918  3932 QIEMDV--NTK--LVKEKYPISDVWDI 3954
Cdd:PTZ00176 1291 HIEMKIlnNTSngSLEQQFPISDVWNI 1317
Duffy_binding pfam05424
Duffy binding domain; This domain is found in Plasmodium Duffy binding proteins. Plasmodium ...
 116-310 1.20e-85

Duffy binding domain; This domain is found in Plasmodium Duffy binding proteins. Plasmodium vivax and Plasmodium knowlesi merozoites invade human erythrocytes that express Duffy blood group surface determinants. The Duffy receptor family is localized in micronemes, an organelle found in all organizms of the phylum Apicomplexa. This family is closely associated on PfEMP1 proteins with PFEMP, pfam03011.


Pssm-ID: 428465 [Multi-domain]  Cd Length: 178  Bit Score: 278.39  E-value: 1.20e-85
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86171918    116 CAPYRRLHLCVQNLEQIKPDQITSTHNLLVDVLLAAKYEGQSITQDYPKYQATYDDSPSKMCTMLARSFADIGDIVRGKD 195
Cdd:pfam05424    2 CAPPRRLHLCVKNLEKINSGNTTTTHDLLKAVILAAKYEGFSLWHKYKKKNTKYGDIPSEFCRQMAYSFADIGDIIRGKD 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86171918    196 LFLGTNEEKKpLEENLKEIFKKIYENLgiqeKNHYNDTPDYYKLREDWWIANRDQVWKAITCNAG-GYSYFRKTCGGDNE 274
Cdd:pfam05424   82 LYLGNNKKKK-LEENLKKIFKKIYEKL----TSKGKDDGNYYQLREDWWEANREDIWKAMTCALTyGAKYFRKTCGDGIS 156

                          170       180       190
                   ....*....|....*....|....*....|....*.
gi 86171918    275 KNSTlasnkcrckdekgeHDTDQVPTYFDYVPQYLR 310
Cdd:pfam05424  157 PSTA--------------GCNDDVPTYFDYVPQFLR 178
PTZ00176 PTZ00176
erythrocyte membrane protein 1 (PfEMP1); Provisional
 15-419 1.18e-70

erythrocyte membrane protein 1 (PfEMP1); Provisional


Pssm-ID: 140204 [Multi-domain]  Cd Length: 1317  Bit Score: 263.82  E-value: 1.18e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86171918    15 SVKDLFDRIGKEVHDQVEKEANqYKEALKGDLSSATFPTGRRH-----EKPQSESCKLNYIYDTNVTSG-GGKENPCYGR 88
Cdd:PTZ00176   14 SARNVLENIGNEIKDKRENESK-YTDKLKGSLWEARFSDGLSSsfgdvRSGYYDSCSLDHKFHTNINNGyPPARNPCDGR 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86171918    89 QGVRFSDTKGAKCYSYKIE--DNDSSIGFCAPYRRLHLCVQNLEQIKPDQITSTHNLLVDVLLAAKYEGQSITQDYPkyq 166
Cdd:PTZ00176   93 NQNRFDENGESYCNSDKIRgnENNSNAGACAPFRRQNMCDKNLEYLINKNTENTHDLLGNVLVTAKYEGESIVNNHP--- 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86171918   167 atyDDSPSKMCTMLARSFADIGDIVRGKDLFLGTNEEKkpLEENLKEIFKKIYENLGIQE-KNHYND--TPDYYKLREDW 243
Cdd:PTZ00176  170 ---DKDKSSVCTALARSFADIGDIVRGKDMFKRNKHDN--VENGLREVFKKIYEGLKNNGaREHYKEvkNGNYIKLREDW 244

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86171918   244 WIANRDQVWKAITCNAGGYSYFRKT-CGGDNEKNSTLASNKCrckdekgEHDTDqvPTYFDYVPQYLRWFEEWAEDFCRK 322
Cdd:PTZ00176  245 WTANRDQVWKAMTCVAPENAYFRKTeADGIGISSLILPYSKC-------GRDTD--PPVVDYIPQRLRWMSEWSEYFCNV 315

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86171918   323 KKIKVENVKKSCRgedkeskdrycsrngyDCEKTKRAIGKLRyGKQCISCLYGCNPYVDWIEKQKEQFDKQKKIYdkeiK 402
Cdd:PTZ00176  316 LNKEIDEMNNQCK----------------DCEMSRRCNNDTE-GEKCKKCKEQCQIFKELVSKWKNQFDKQSMKY----M 374

                         410
                  ....*....|....*..
gi 86171918   403 KYENGASSSSRKTRAAS 419
Cdd:PTZ00176  375 ELYNKASTNITKQNSSA 391
PTZ00176 PTZ00176
erythrocyte membrane protein 1 (PfEMP1); Provisional
 907-1601 4.74e-66

erythrocyte membrane protein 1 (PfEMP1); Provisional


Pssm-ID: 140204 [Multi-domain]  Cd Length: 1317  Bit Score: 249.18  E-value: 4.74e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86171918   907 EPCKGKdgNNERFKIGTEWKIG-EKVETSYKD----VFLPPRRQHMCTSNLENLdvdsVTENDKASHSLLGDVQLAAKTD 981
Cdd:PTZ00176   87 NPCDGR--NQNRFDENGESYCNsDKIRGNENNsnagACAPFRRQNMCDKNLEYL----INKNTENTHDLLGNVLVTAKYE 160

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86171918   982 AAEIIKRYKDqnniqltdpiqqKDQEAMCRAIRYSFADLGDIIRGRDMWnKDSGSTEMEKHLISIFEKINEKLPE---KE 1058
Cdd:PTZ00176  161 GESIVNNHPD------------KDKSSVCTALARSFADIGDIVRGKDMF-KRNKHDNVENGLREVFKKIYEGLKNngaRE 227

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86171918  1059 QKKYSNDGKYLDLRKDWWEANRYKVWKAMKC-ATKNS---KIPCSGI------------------PIEDYIPQRLRWMTE 1116
Cdd:PTZ00176  228 HYKEVKNGNYIKLREDWWTANRDQVWKAMTCvAPENAyfrKTEADGIgisslilpyskcgrdtdpPVVDYIPQRLRWMSE 307

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86171918  1117 WAEWFCKEQSQAYETLQDQCGKCTGPNKDNCTRDNNDCNTCTKACEEYEQKIKKWADQWKVISKKYEELYLQAKTAFART 1196
Cdd:PTZ00176  308 WSEYFCNVLNKEIDEMNNQCKDCEMSRRCNNDTEGEKCKKCKEQCQIFKELVSKWKNQFDKQSMKYMELYNKASTNITKQ 387

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86171918  1197 AFPDDDPDYQQvveffkelqkeinrsaSQRSKRSIDVTNTDPtltspyssaagYIHQEIGNVGCNVQ--------TQFCE 1268
Cdd:PTZ00176  388 NSSAPERGYRR----------------NHRRRGYDDDTNVQL-----------FLKKVIENNECKVEslgkyldkTSHCG 440

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86171918  1269 KKNGVIPTTgSGTNNKNyAFKNTPKDHDEACECESRPQVPPKKKEDEEDVCEKVKgllkgkdgettEINGCKP---KGNG 1345
Cdd:PTZ00176  441 NYNFNYDNT-PGSNRSN-AFEITPEKFKKACKCKIPNPLEKCPNEENKNVCTRFD-----------KVYSCTSlsfKNDL 507

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86171918  1346 NTWNCS---NQIDDSHkGACMPPRRQSLCIhNL--KESNETGTEQQLREAFINCAAIETFWLWYKYKKDKNvdaekkleq 1420
Cdd:PTZ00176  508 SEWNNSgvkNKENDNN-GVLVPPRRRNLCI-NLfsKKDYKMKDENDFKEDLLNAAFSQGKLLGKKYSNYSN--------- 576

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86171918  1421 geipsEFLRSMIYTFGDYRDLCLNTDIsakkdpikivKNNIQKVFNRNNGPHKEGDKEK----RKKFWETNKNDIWQGML 1496
Cdd:PTZ00176  577 -----EAYEAMKFSYADYSDIVKGTDM----------MNDLKKLNKELNTLLKETEKGDisvdRKTWWDDNKNVVWNAML 641

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86171918  1497 CALeKIANNKKTLTETYnyslvkfsgnnsTTLEDFAKTPQFLRWFTEWGDDFCqqqKEQLVtlQEACPNGICEQSEEEKK 1576
Cdd:PTZ00176  642 CGY-KTENENQQLNSSW------------CNVPDDDNIDQFLRWLTEWAQQYC---KEKLI--KAHIINTKCKDIVEGRK 703

                         730       740       750
                  ....*....|....*....|....*....|....*....
gi 86171918  1577 ----------KCKSACEKYQAFIE----KWKGYYDKQSK 1601
Cdd:PTZ00176  704 hksmvditdvECKRLFIDYEEWFRyrynQWKGLSEKYIK 742
PTZ00176 PTZ00176
erythrocyte membrane protein 1 (PfEMP1); Provisional
 2536-3067 1.24e-55

erythrocyte membrane protein 1 (PfEMP1); Provisional


Pssm-ID: 140204 [Multi-domain]  Cd Length: 1317  Bit Score: 215.67  E-value: 1.24e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86171918  2536 AMERSYADYGTIVKEDILWDYEDKKKIDPKIMN-FAKNHNISTTKTIVSSLDDDD----VK-RQKLWESIRIDVWKAMIC 2609
Cdd:PTZ00176  179 ALARSFADIGDIVRGKDMFKRNKHDNVENGLREvFKKIYEGLKNNGAREHYKEVKngnyIKlREDWWTANRDQVWKAMTC 258

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86171918  2610 -----GY---KDAIGGDMNSLPNDVDLC----TLPTTDDEYSFLRWFVEWGQNFCIRHEKELKQLNEEC-----ARGTCD 2672
Cdd:PTZ00176  259 vapenAYfrkTEADGIGISSLILPYSKCgrdtDPPVVDYIPQRLRWMSEWSEYFCNVLNKEIDEMNNQCkdcemSRRCNN 338

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86171918  2673 GTDEEKKKKCEKACKNYREFLNNFKKQYENQKKEY---------EIIK--SSYPK-----------YEKKDAFTFLKDKC 2730
Cdd:PTZ00176  339 DTEGEKCKKCKEQCQIFKELVSKWKNQFDKQSMKYmelynkastNITKqnSSAPErgyrrnhrrrgYDDDTNVQLFLKKV 418

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86171918  2731 NSNYSC---------------------FENKTEISVLKMFEHPPDDVKDECDCKTSKAHDDKVNDLDKCPNNINNNKNIc 2789
Cdd:PTZ00176  419 IENNECkveslgkyldktshcgnynfnYDNTPGSNRSNAFEITPEKFKKACKCKIPNPLEKCPNEENKNVCTRFDKVYS- 497

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86171918  2790 nkykkrriCGDLKYSNSLDHWFGTNT----------LIPPRRRHLCLrNIIIKKNYRKGDISKFKDDLFYAAASEAKFLF 2859
Cdd:PTZ00176  498 --------CTSLSFKNDLSEWNNSGVknkendnngvLVPPRRRNLCI-NLFSKKDYKMKDENDFKEDLLNAAFSQGKLLG 568

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86171918  2860 NNYEN-KNESLQAIKYTFADIGDIIKGNDMMDDMtyKKIKGKLEKVLDKT--GNNPETPEKWWEQNKKHVWEAMLCGYKL 2936
Cdd:PTZ00176  569 KKYSNySNEAYEAMKFSYADYSDIVKGTDMMNDL--KKLNKELNTLLKETekGDISVDRKTWWDDNKNVVWNAMLCGYKT 646

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86171918  2937 AGGEIKPND--CNIPTEESTHQFLRWLTEWGTQYCKEK--QQLKLNMQIPCMTHFDKYGIIENRIDVHpnCLQGLGKYEI 3012
Cdd:PTZ00176  647 ENENQQLNSswCNVPDDDNIDQFLRWLTEWAQQYCKEKliKAHIINTKCKDIVEGRKHKSMVDITDVE--CKRLFIDYEE 724

                         570       580       590       600       610
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 86171918  3013 WSNNRIPDWERLSSKFNEVKGTMNENV---KKLTAYEYLKQNCSKCICSFKDIEQTHK 3067
Cdd:PTZ00176  725 WFRYRYNQWKGLSEKYIKIKKSKNSGVnipSEECAASYVTKHCNGCICNLRDMEDIHK 782
Duffy_binding pfam05424
Duffy binding domain; This domain is found in Plasmodium Duffy binding proteins. Plasmodium ...
 1361-1539 5.03e-47

Duffy binding domain; This domain is found in Plasmodium Duffy binding proteins. Plasmodium vivax and Plasmodium knowlesi merozoites invade human erythrocytes that express Duffy blood group surface determinants. The Duffy receptor family is localized in micronemes, an organelle found in all organizms of the phylum Apicomplexa. This family is closely associated on PfEMP1 proteins with PFEMP, pfam03011.


Pssm-ID: 428465 [Multi-domain]  Cd Length: 178  Bit Score: 167.84  E-value: 5.03e-47
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86171918   1361 ACMPPRRQSLCIHNLK--ESNETGTEQQLREAFINCAAIETFWLWYKYKKDKNVDaekkleqGEIPSEFLRSMIYTFGDY 1438
Cdd:pfam05424    1 ACAPPRRLHLCVKNLEkiNSGNTTTTHDLLKAVILAAKYEGFSLWHKYKKKNTKY-------GDIPSEFCRQMAYSFADI 73

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86171918   1439 RDLCLNTDISAKKDPIKIVKNNIQKVFNRNNGPHKEGDK------EKRKKFWETNKNDIWQGMLCALEKiaNNKKTLTET 1512
Cdd:pfam05424   74 GDIIRGKDLYLGNNKKKKLEENLKKIFKKIYEKLTSKGKddgnyyQLREDWWEANREDIWKAMTCALTY--GAKYFRKTC 151

                          170       180
                   ....*....|....*....|....*..
gi 86171918   1513 YNYSLVKFSGNNSTTLEDFAKTPQFLR 1539
Cdd:pfam05424  152 GDGISPSTAGCNDDVPTYFDYVPQFLR 178
Duffy_binding pfam05424
Duffy binding domain; This domain is found in Plasmodium Duffy binding proteins. Plasmodium ...
 1762-1940 2.01e-35

Duffy binding domain; This domain is found in Plasmodium Duffy binding proteins. Plasmodium vivax and Plasmodium knowlesi merozoites invade human erythrocytes that express Duffy blood group surface determinants. The Duffy receptor family is localized in micronemes, an organelle found in all organizms of the phylum Apicomplexa. This family is closely associated on PfEMP1 proteins with PFEMP, pfam03011.


Pssm-ID: 428465 [Multi-domain]  Cd Length: 178  Bit Score: 134.71  E-value: 2.01e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86171918   1762 CIPPRRQQMYIQPLQSLSGNE--SQVELRRIFIEMAAIETFFQWHKFKKekvreikekdeidgkislfgqddtsieenlq 1839
Cdd:pfam05424    2 CAPPRRLHLCVKNLEKINSGNttTTHDLLKAVILAAKYEGFSLWHKYKK------------------------------- 50

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86171918   1840 KQLKNGTIPDDFKRQMFYTFGDYKDILFGK--YIG-IDMGTVKTNIGRVFNNGGNK----------SDEEREKWWKNHGP 1906
Cdd:pfam05424   51 KNTKYGDIPSEFCRQMAYSFADIGDIIRGKdlYLGnNKKKKLEENLKKIFKKIYEKltskgkddgnYYQLREDWWEANRE 130

                          170       180       190
                   ....*....|....*....|....*....|....
gi 86171918   1907 SIWNGMLCGLSYDTKTKHNIQGVYTQLTDPSKNN 1940
Cdd:pfam05424  131 DIWKAMTCALTYGAKYFRKTCGDGISPSTAGCND 164
PFEMP pfam03011
PFEMP1 DBL domain; PfEMP1 (Plasmodium falciparum erythrocyte membrane protein) has been ...
 652-811 1.05e-30

PFEMP1 DBL domain; PfEMP1 (Plasmodium falciparum erythrocyte membrane protein) has been identified as the rosetting ligand of the malaria parasite P. falciparum. Rosetting is the adhesion of infected erythrocytes with uninfected erythrocytes in the vasculature of the infected organ, and is associated with severe malaria. PfEMP1 interacts with Complement Receptor One on uninfected erythrocytes to form rosettes. The extreme variation within these proteins and the grouping of var genes implies that var gene recombination preferentially occurs within var gene groups. These groups reflect a functional diversification that has evolved to cope with the varying conditions of transmission and host immune response met by the parasite. A recombination hotspot was uncovered between Duffy-binding-like (DBL) subdomains. Solution of the crystal structure of the N-terminal and first DBL region of PfEMP1 from the VarO variant of the PfEMP1 protein is found to be directly implicated in rosetting as the heparin-binding site.


Pssm-ID: 281064  Cd Length: 154  Bit Score: 120.29  E-value: 1.05e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86171918    652 FFYYWVAHMLKDSIHWKKKLQRCLEKKNGNTCKKnNCKDNCGCFEKWVAQKKEqEWDPIKQQFRKQDFGKqELILGQIRY 731
Cdd:pfam03011    1 LFKRWVEYFLEDSIKWRKKLKSCINNGKGKCCKK-ECKNDCECFKKWVEKKKE-EWKKIKEHFLKQYKLK-GLTGKTLDE 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86171918    732 DYVLDELLKKDELLTSIKEGYGDANEIKHIKALLEDEENEETQEEetaGADNQKKNTIDWLIQHEEDDAELCLEIHEDEE 811
Cdd:pfam03011   78 YLDLKSFLETFLFYIDIKEAYGDVKELKKLEEILDEEGCSAGAES---AKNNKNEDAIDKLLDKEEKKANNCKEKHKEND 154
PTZ00176 PTZ00176
erythrocyte membrane protein 1 (PfEMP1); Provisional
 1337-1997 1.33e-28

erythrocyte membrane protein 1 (PfEMP1); Provisional


Pssm-ID: 140204 [Multi-domain]  Cd Length: 1317  Bit Score: 127.07  E-value: 1.33e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86171918  1337 NGCKPKGNGNTWNCsnqiddshkGACMPPRRQSLCIHNLK---ESNETGTEQQLREAFINCaaietfwlwyKYKKDKNVD 1413
Cdd:PTZ00176  106 NSDKIRGNENNSNA---------GACAPFRRQNMCDKNLEyliNKNTENTHDLLGNVLVTA----------KYEGESIVN 166

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86171918  1414 AEKKLEQGEIPSEFLRSmiytFGDYRDLCLNTDIsAKKDPIKIVKNNIQKVFNR-NNGPHKEGDKEK------------R 1480
Cdd:PTZ00176  167 NHPDKDKSSVCTALARS----FADIGDIVRGKDM-FKRNKHDNVENGLREVFKKiYEGLKNNGAREHykevkngnyiklR 241

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86171918  1481 KKFWETNKNDIWQGMLCALEKIANNKKTLTETYNYSLV-----KFSGNNSTTLEDFakTPQFLRWFTEWGDDFCQQQKEQ 1555
Cdd:PTZ00176  242 EDWWTANRDQVWKAMTCVAPENAYFRKTEADGIGISSLilpysKCGRDTDPPVVDY--IPQRLRWMSEWSEYFCNVLNKE 319

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86171918  1556 LVTLQEACPNgiCEQSE--------EEKKKCKSACEKYQAFIEKWKGYYDKQSKKY---FYDISTGMYKDNSSA------ 1618
Cdd:PTZ00176  320 IDEMNNQCKD--CEMSRrcnndtegEKCKKCKEQCQIFKELVSKWKNQFDKQSMKYmelYNKASTNITKQNSSApergyr 397

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86171918  1619 --------KDDVTVSSYayeylnksLKKLCPDGSCSC------MEQRSQQHNEDsSDALETHNSIMPQSLDKEPKEVKGR 1684
Cdd:PTZ00176  398 rnhrrrgyDDDTNVQLF--------LKKVIENNECKVeslgkyLDKTSHCGNYN-FNYDNTPGSNRSNAFEITPEKFKKA 468

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86171918  1685 CKC--PDPPKPCDIVkdlfENKDD-NKFTEACSTKYKNGKEKYTQWkciNDSSNTTRssppapvasstlstspEAGASAT 1761
Cdd:PTZ00176  469 CKCkiPNPLEKCPNE----ENKNVcTRFDKVYSCTSLSFKNDLSEW---NNSGVKNK----------------ENDNNGV 525

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86171918  1762 CIPPRRQQMYIqplqslsgnesqvelrrifiemaaietffqwHKFKKekvREIKEKDEIDGKISLFGQdDTSIEENLQKQ 1841
Cdd:PTZ00176  526 LVPPRRRNLCI-------------------------------NLFSK---KDYKMKDENDFKEDLLNA-AFSQGKLLGKK 570

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86171918  1842 LKNGTipDDFKRQMFYTFGDYKDILFGKYIGIDMGTVKTNIGRVFNNgGNKSD--EEREKWWKNHGPSIWNGMLCGlsYD 1919
Cdd:PTZ00176  571 YSNYS--NEAYEAMKFSYADYSDIVKGTDMMNDLKKLNKELNTLLKE-TEKGDisVDRKTWWDDNKNVVWNAMLCG--YK 645

                         650       660       670       680       690       700       710
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 86171918  1920 TKTKhNIQGVYTQLTDPSKNNmyekvtfpsktgpsvntkLEQFarrptyFRWLEEWGEEFCKKRTDKLKKLEKECRGV 1997
Cdd:PTZ00176  646 TENE-NQQLNSSWCNVPDDDN------------------IDQF------LRWLTEWAQQYCKEKLIKAHIINTKCKDI 698
Duffy_binding pfam05424
Duffy binding domain; This domain is found in Plasmodium Duffy binding proteins. Plasmodium ...
 2817-2933 6.15e-26

Duffy binding domain; This domain is found in Plasmodium Duffy binding proteins. Plasmodium vivax and Plasmodium knowlesi merozoites invade human erythrocytes that express Duffy blood group surface determinants. The Duffy receptor family is localized in micronemes, an organelle found in all organizms of the phylum Apicomplexa. This family is closely associated on PfEMP1 proteins with PFEMP, pfam03011.


Pssm-ID: 428465 [Multi-domain]  Cd Length: 178  Bit Score: 107.36  E-value: 6.15e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86171918   2817 IPPRRRHLCLRNIIIKKNYRKGDISKFKDDLFYAAASEAKFLFNNYENKNES--------LQAIKYTFADIGDIIKGNDM 2888
Cdd:pfam05424    3 APPRRLHLCVKNLEKINSGNTTTTHDLLKAVILAAKYEGFSLWHKYKKKNTKygdipsefCRQMAYSFADIGDIIRGKDL 82

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 86171918   2889 -MDDMTYKKIKGKLEKVLDKTGNNP-----------ETPEKWWEQNKKHVWEAMLCG 2933
Cdd:pfam05424   83 yLGNNKKKKLEENLKKIFKKIYEKLtskgkddgnyyQLREDWWEANREDIWKAMTCA 139
PFEMP pfam03011
PFEMP1 DBL domain; PfEMP1 (Plasmodium falciparum erythrocyte membrane protein) has been ...
 2223-2367 1.70e-21

PFEMP1 DBL domain; PfEMP1 (Plasmodium falciparum erythrocyte membrane protein) has been identified as the rosetting ligand of the malaria parasite P. falciparum. Rosetting is the adhesion of infected erythrocytes with uninfected erythrocytes in the vasculature of the infected organ, and is associated with severe malaria. PfEMP1 interacts with Complement Receptor One on uninfected erythrocytes to form rosettes. The extreme variation within these proteins and the grouping of var genes implies that var gene recombination preferentially occurs within var gene groups. These groups reflect a functional diversification that has evolved to cope with the varying conditions of transmission and host immune response met by the parasite. A recombination hotspot was uncovered between Duffy-binding-like (DBL) subdomains. Solution of the crystal structure of the N-terminal and first DBL region of PfEMP1 from the VarO variant of the PfEMP1 protein is found to be directly implicated in rosetting as the heparin-binding site.


Pssm-ID: 281064  Cd Length: 154  Bit Score: 93.72  E-value: 1.70e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86171918   2223 LFHRWITDFIQYYNKSKEKIKPCTNDVN--SCKQGCKGNCDCVDKWLKNKSTEWEIIKKYYKENFGNTNEHIAYA----- 2295
Cdd:pfam03011    1 LFKRWVEYFLEDSIKWRKKLKSCINNGKgkCCKKECKNDCECFKKWVEKKKEEWKKIKEHFLKQYKLKGLTGKTLdeyld 80

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 86171918   2296 IKIFLQEGLFDSDYKRAQEVIDQ-NEWEQLWGCTGDNLKDVkdqKAENCNKGDFITNLISKLQDKITSCQNKH 2367
Cdd:pfam03011   81 LKSFLETFLFYIDIKEAYGDVKElKKLEEILDEEGCSAGAE---SAKNNKNEDAIDKLLDKEEKKANNCKEKH 150
Duffy_binding pfam05424
Duffy binding domain; This domain is found in Plasmodium Duffy binding proteins. Plasmodium ...
 2464-2636 2.29e-17

Duffy binding domain; This domain is found in Plasmodium Duffy binding proteins. Plasmodium vivax and Plasmodium knowlesi merozoites invade human erythrocytes that express Duffy blood group surface determinants. The Duffy receptor family is localized in micronemes, an organelle found in all organizms of the phylum Apicomplexa. This family is closely associated on PfEMP1 proteins with PFEMP, pfam03011.


Pssm-ID: 428465 [Multi-domain]  Cd Length: 178  Bit Score: 82.71  E-value: 2.29e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86171918   2464 VYISPRAHQLYLEPLKDLKENNT-DKNELIKAFTKCAYNEGKCLYEYYSKNKATLGKngsalSNDEVKTytleAMERSYA 2542
Cdd:pfam05424    1 ACAPPRRLHLCVKNLEKINSGNTtTTHDLLKAVILAAKYEGFSLWHKYKKKNTKYGD-----IPSEFCR----QMAYSFA 71

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86171918   2543 DYGTIVK-EDILWDYEDKKKIDPKIMN-FAKNHNisTTKTIVSSLDDDDVKRQKLWESIRIDVWKAMICG------YKDA 2614
Cdd:pfam05424   72 DIGDIIRgKDLYLGNNKKKKLEENLKKiFKKIYE--KLTSKGKDDGNYYQLREDWWEANREDIWKAMTCAltygakYFRK 149

                          170       180
                   ....*....|....*....|..
gi 86171918   2615 IGGDMNSLPNDVDLCTLPTTDD 2636
Cdd:pfam05424  150 TCGDGISPSTAGCNDDVPTYFD 171
PTZ00176 PTZ00176
erythrocyte membrane protein 1 (PfEMP1); Provisional
 105-335 3.90e-13

erythrocyte membrane protein 1 (PfEMP1); Provisional


Pssm-ID: 140204 [Multi-domain]  Cd Length: 1317  Bit Score: 76.23  E-value: 3.90e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86171918   105 KIEDNDSSiGFCAPYRRLHLCVqNLEQIKPDQITSTHNLLVDVLLAAKYEGQSITQDYPKYQatyddspSKMCTMLARSF 184
Cdd:PTZ00176  516 KNKENDNN-GVLVPPRRRNLCI-NLFSKKDYKMKDENDFKEDLLNAAFSQGKLLGKKYSNYS-------NEAYEAMKFSY 586

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86171918   185 ADIGDIVRGKDLFLGTNEEKKPLEENLKEIFKKiyenlgiqeknhyndtpDYYKLREDWWIANRDQVWKAITCnagGYsy 264
Cdd:PTZ00176  587 ADYSDIVKGTDMMNDLKKLNKELNTLLKETEKG-----------------DISVDRKTWWDDNKNVVWNAMLC---GY-- 644

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 86171918   265 frKTcggDNEkNSTLASNKCRCKDEkgehdtdqvptyfDYVPQYLRWFEEWAEDFCRKKKIKVENVKKSCR 335
Cdd:PTZ00176  645 --KT---ENE-NQQLNSSWCNVPDD-------------DNIDQFLRWLTEWAQQYCKEKLIKAHIINTKCK 696
NTS pfam15447
N-terminal segments of PfEMP1; This family, the N-terminal segment, is the most variable part ...
 15-50 1.36e-12

N-terminal segments of PfEMP1; This family, the N-terminal segment, is the most variable part of the variant surface antigen family of Plasmodium falciparum, the erythrocyte membrane protein-1 (PfEMP1) proteins. PfEMP1 is an important target for protective immunity and is implicated in the pathology of malaria through its ability to adhere to host endothelial receptors. A structural and functional study of the N-terminal domain of PfEMP1 from the VarO variant comprising the N-terminal segment (NTS) and the first DBL domain (DBL1alpha1), shows this region is directly implicated in rosetting. NTS, previously thought to be a structurally independent component of PfEMP1, forms an integral part of the DBL1alpha domain that is found to be the important heparin-binding site. This family is closely associated with PFEMP, pfam03011, and Duffy_binding, pfam05424.


Pssm-ID: 406013 [Multi-domain]  Cd Length: 36  Bit Score: 64.34  E-value: 1.36e-12
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 86171918     15 SVKDLFDRIGKEVHDQVEKEANQYKEALKGDLSSAT 50
Cdd:pfam15447    1 SAKHLLDRIGKDVHDKVKKEAKRYKSELKGDLSKAK 36
PTZ00176 PTZ00176
erythrocyte membrane protein 1 (PfEMP1); Provisional
 1897-2072 1.03e-07

erythrocyte membrane protein 1 (PfEMP1); Provisional


Pssm-ID: 140204 [Multi-domain]  Cd Length: 1317  Bit Score: 58.51  E-value: 1.03e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86171918  1897 REKWWKNHGPSIWNGMLCGL---SYDTKTKHNIQGVYTQLTDPSKNNmyekvtfpSKTGPSVNTKLeqfarrPTYFRWLE 1973
Cdd:PTZ00176  241 REDWWTANRDQVWKAMTCVApenAYFRKTEADGIGISSLILPYSKCG--------RDTDPPVVDYI------PQRLRWMS 306

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86171918  1974 EWGEEFCKKRTDKLKKLEKECRGVNYSgynKYCSgdgyhcDDEKGTynsinanlNCRDCMKECRNYKTWIVKKKNEYDKQ 2053
Cdd:PTZ00176  307 EWSEYFCNVLNKEIDEMNNQCKDCEMS---RRCN------NDTEGE--------KCKKCKEQCQIFKELVSKWKNQFDKQ 369

                         170
                  ....*....|....*....
gi 86171918  2054 KSKYVNEHENVISFLNKQS 2072
Cdd:PTZ00176  370 SMKYMELYNKASTNITKQN 388
LbR_Ice_bind cd12796
Ice-binding protein, left-handed beta-roll; The ice-binding protein of the grass Lolium ...
 3634-3753 2.57e-04

Ice-binding protein, left-handed beta-roll; The ice-binding protein of the grass Lolium perenne (LpIBP) discourages the recrystallization of ice. Ice-binding proteins produced by organisms to prevent the growing of ice are termed to anti-freeze proteins. LpIBP consists of an unusual left-handed beta roll. Ice-binding is mediated by a flat beta-sheet on one side of the helix.


Pssm-ID: 240609 [Multi-domain]  Cd Length: 114  Bit Score: 43.16  E-value: 2.57e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86171918 3634 VEEKPFIMSIHDRNLYTGEEYNYDMSTN---SGNNDLYNGKNNLYSGQNNVYSGidptsdNRGPYSDKNDRISDNHHPYS 3710
Cdd:cd12796   13 SGSENNVIAGGQNLVVSGSNNLVSGGNHnvlSGNNNTVSGNNHVVTGSNNVVTG------NGNTVSGSNNVVSGSNNTVS 86

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 86171918 3711 GidlINDTLSGNAHIdiydellkrkeneLFGTNHVKHTSTHSV 3753
Cdd:cd12796   87 G---GNNTVSGSNNT-------------VSGSNHIVSGNNKVV 113
 
Name Accession Description Interval E-value
ATS pfam15445
acidic terminal segments, variant surface antigen of PfEMP1; ATS is the intracellular and ...
 3444-3954 0e+00

acidic terminal segments, variant surface antigen of PfEMP1; ATS is the intracellular and relatively conserved acidic terminal segment of the Plasmodium falciparum erythrocyte membrane protein-1 (PfEMP1). this domain appears to be present in all variants of the highly polymorphic PfEMP1 proteins.


Pssm-ID: 373851 [Multi-domain]  Cd Length: 446  Bit Score: 715.43  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86171918   3444 TIPFGVALALGSIAFLFLKKKTQAPV-DLFSVINIPKGDHDIPTLKSSNRYIPYVSDRYKGKTYIYMEGDSDSGH---YY 3519
Cdd:pfam15445    1 TIPWSVGIAFAAFTYFFLKKKTKSSVgNLFQILQIPKGDYDIPTLKSKNRYIPYASDRYKGKTYIYMEGDSSGDEkyaFM 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86171918   3520 EDTTDITSSESEYEELDINDIYPYKSPKYKTLIEVVLEPSGNNTPTsdtPSDTQNDIPSGDTP-NNKLTDNEWNTLKDEF 3598
Cdd:pfam15445   81 SDTTDITSSESEYEELDINDIYVPGSPKYKTLIEVVLEPSKNNTNT---PSDTQNDIPSDDIPsTNKITDEEWNTLKHDF 157

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86171918   3599 ISQYIQSEQpNDVPNDYTSGNSSTNTNITTTSRHNVEEKPFIMSIHDRNLYTGEEYNYD--MSTNSGNNDLYNGKNNLYS 3676
Cdd:pfam15445  158 ISNMLQNTQ-NDEPNILHSGNVPNNTHPNTLSRDNMEEKPFIMSIHDRNLYTGEEYSYNinMSTNSMDDIPKYVSNNVYS 236

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86171918   3677 GqnnvysgidptsdnrgpysdkndrisdnhhpysgIDLINDTLSGNAHIDIYDELLKRKENELFGTNHVKHTSTHSVAKH 3756
Cdd:pfam15445  237 G----------------------------------IDLINDTLSGNQHIDIYDEVLKRKENELFGTNHTKHTSTNSVAKN 282

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86171918   3757 TNSDPIHNQLNLFHTWLDRHRDMCEKWNTKEELLDKLNEQWNKDNNNSGNINPSgntpptsdipsgklSDIPSDNNihsd 3836
Cdd:pfam15445  283 TNSDPILNQLNLFHKWLDRHRDMCEKWKNKEERLDKLKEEWNKENNHSGDIHPS--------------DDIPSDNK---- 344

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86171918   3837 ipyVLNTDVSIQIDMNNPKTTNEFtyvdsnpnqvddTYVDSNPDNSSMDTILEDLDKpFNEPyYYDMYDDDIYYDVHDHD 3916
Cdd:pfam15445  345 ---VLNTDVSIQIDMDNPKPKNEF------------TNMDTNPDNSTMDTILDDLEK-YNEP-YYDIYEDDIYYDVNDHD 407

                          490       500       510
                   ....*....|....*....|....*....|....*....
gi 86171918   3917 TSTVDTNAMDVPSKVQIEMDVNT-KLVKEKYPISDVWDI 3954
Cdd:pfam15445  408 ASTVDSNNMDVPSKVQIEMDVNNtKLVEEKYPISDVWNI 446
PTZ00176 PTZ00176
erythrocyte membrane protein 1 (PfEMP1); Provisional
 2817-3954 0e+00

erythrocyte membrane protein 1 (PfEMP1); Provisional


Pssm-ID: 140204 [Multi-domain]  Cd Length: 1317  Bit Score: 611.27  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86171918  2817 IPPRRRHLCLRNIIIKKNYRKGDISKFKDDLFYAAASEAKFLFNNYENKNES--LQAIKYTFADIGDIIKGNDMMDDMTY 2894
Cdd:PTZ00176  123 APFRRQNMCDKNLEYLINKNTENTHDLLGNVLVTAKYEGESIVNNHPDKDKSsvCTALARSFADIGDIVRGKDMFKRNKH 202

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86171918  2895 KKIKGKLEKVL------------------DKTGNNPETPEKWWEQNKKHVWEAMLC---------GYKLAGGEIKP---- 2943
Cdd:PTZ00176  203 DNVENGLREVFkkiyeglknngarehykeVKNGNYIKLREDWWTANRDQVWKAMTCvapenayfrKTEADGIGISSlilp 282

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86171918  2944 -----NDCNIPTEESTHQFLRWLTEWGTQYCKekqqlKLNMQIPCMTHFDKYGIIENRIDVHP---NCLQGLGKYEI--- 3012
Cdd:PTZ00176  283 yskcgRDTDPPVVDYIPQRLRWMSEWSEYFCN-----VLNKEIDEMNNQCKDCEMSRRCNNDTegeKCKKCKEQCQIfke 357

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86171918  3013 ----WSNnripDWERLSSKFNEVKGTMNENVKKLTA---------------YE-------YLKQNCSKCICSFKDIEQTH 3066
Cdd:PTZ00176  358 lvskWKN----QFDKQSMKYMELYNKASTNITKQNSsapergyrrnhrrrgYDddtnvqlFLKKVIENNECKVESLGKYL 433

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86171918  3067 KKSKDEG-YHIYEDILDKAQIPSFLEDTAYRYKGL------NP--ECPEDIE---CSQYGNI-PCRGVSHDDD-NDWNSS 3132
Cdd:PTZ00176  434 DKTSHCGnYNFNYDNTPGSNRSNAFEITPEKFKKAckckipNPleKCPNEENknvCTRFDKVySCTSLSFKNDlSEWNNS 513

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86171918  3133 FVKDNKTTNLGVLVPPRRRHLCLRIDVNKFLRLRnDINNLKTFICKSAFAEAKRLKKVYKDDNSKLHQAMKYSFSDIGSV 3212
Cdd:PTZ00176  514 GVKNKENDNNGVLVPPRRRNLCINLFSKKDYKMK-DENDFKEDLLNAAFSQGKLLGKKYSNYSNEAYEAMKFSYADYSDI 592

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86171918  3213 VKGNDMMESPTSDNiAKIFRGMKYTE-----INRETWWDLNKYHVWESMLCGYR-EAGGDTKKSENCRFPDIERVPQFLR 3286
Cdd:PTZ00176  593 VKGTDMMNDLKKLN-KELNTLLKETEkgdisVDRKTWWDDNKNVVWNAMLCGYKtENENQQLNSSWCNVPDDDNIDQFLR 671

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86171918  3287 WFQEWTEIFCIKRKTLYDKMVTECQ---KAECDTSNGTVKETKCTKAC---EEYKSYVLSKKK---EYYIQKDKYDNQFK 3357
Cdd:PTZ00176  672 WLTEWAQQYCKEKLIKAHIINTKCKdivEGRKHKSMVDITDVECKRLFidyEEWFRYRYNQWKglsEKYIKIKKSKNSGV 751

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86171918  3358 KVLNNKDAEEFLNVHC-------------------LSEYFK--------DETRWKNPYESIADKALKGKCDCKKMIPTTP 3410
Cdd:PTZ00176  752 NIPSEECAASYVTKHCngcicnlrdmedihkninnQNELMKeminiikfDTDQYRTQLQNISNSMEINPKSVKTAVDTTK 831

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86171918  3411 EV-----------------------KPKKPAVPEAKKPeVEPLPSDEPFNRDILEK---TIP--FGVALALGSIAFLfLK 3462
Cdd:PTZ00176  832 DIvsyglagtmgvaaiglqagdflgKKIQDLYNEFMKP-VEKKLDTSSKNLNIYEDpniMVPagIGVALTLGLLLFK-MR 909

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86171918  3463 KKTQAPVDLFSVINIPKGDHDIPTLKSSNRYIPYVSDRYKGKTYIYMEGDSDSGHYY--EDTTDITSSESEYEELDINDI 3540
Cdd:PTZ00176  910 RKAKRQVDMIRILQMSQNEYGIPTTKSPNKYVPYGSQRYKGKTYLYVEGDTDEEKYMfmSDTTDITSSESEYEEMDINDI 989

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86171918  3541 YPYKSPKYKTLIEVVLEPSgnntptsdtPSDTQNDIPSGDTPNNKLTDNEWNTLKDEFISQYIQSEQPNdvpNDYTSGNS 3620
Cdd:PTZ00176  990 YVPGSPKYKTLIEVVLEPS---------KRDTQNDIPSDNTPSYKLTDEEWNQLKDDFISQYLPNTEPN---NNYRSGNS 1057

                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86171918  3621 STNTNITTTSRHNVEEKPFIMSIHDRNLYTGEE--YNYDMSTNSGNNDLYNgknnlysgQNNVYSGIDptsdnrgpysdk 3698
Cdd:PTZ00176 1058 PTNTNNTTTSHDNMGEKPFIMSIHDRNLYTGEEisYNINMSTNTMDDPKYV--------SNNVYSGID------------ 1117

                        1050      1060      1070      1080      1090      1100      1110      1120
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86171918  3699 ndrisdnhhpysgidLINDTLSGNAHIDIYDELLKRKENELFGTNHVKHTSTHSVAKHT-NSDPIHNQLNLFHTWLDRHR 3777
Cdd:PTZ00176 1118 ---------------LINDTLSGNQHIDIYDEVLKRKENELFGTNHVKQTSIHSVAKNTySDDAITNKINLFHKWLDRHR 1182

                        1130      1140      1150      1160      1170      1180      1190      1200
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86171918  3778 DMCEKWNTKEELLDKLNEQWNKDNNNsgninpsgntpptsdipsgklSDIPSDNnihsdipYVLNTDVSIQIDMNNPKTT 3857
Cdd:PTZ00176 1183 DMCEKWENHHERLAKLKEKWENDNDG---------------------GNVPSDN-------HVLNTDVSIEIDMDNPKPI 1234

                        1210      1220      1230      1240      1250      1260      1270      1280
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86171918  3858 NEFTYVDSNP------NQVDDTYVDSNpDNSsmdtilEDLDKPfnepyyydmydddiYYDVHDHDTSTVDtnaMDVPSKV 3931
Cdd:PTZ00176 1235 NQFSNMDINVdtptmdNMEDDIYYDVN-DND------DDNDQP--------------SVYDIPMDHNKVD---VDVPKKV 1290

                        1290      1300
                  ....*....|....*....|....*..
gi 86171918  3932 QIEMDV--NTK--LVKEKYPISDVWDI 3954
Cdd:PTZ00176 1291 HIEMKIlnNTSngSLEQQFPISDVWNI 1317
Duffy_binding pfam05424
Duffy binding domain; This domain is found in Plasmodium Duffy binding proteins. Plasmodium ...
 116-310 1.20e-85

Duffy binding domain; This domain is found in Plasmodium Duffy binding proteins. Plasmodium vivax and Plasmodium knowlesi merozoites invade human erythrocytes that express Duffy blood group surface determinants. The Duffy receptor family is localized in micronemes, an organelle found in all organizms of the phylum Apicomplexa. This family is closely associated on PfEMP1 proteins with PFEMP, pfam03011.


Pssm-ID: 428465 [Multi-domain]  Cd Length: 178  Bit Score: 278.39  E-value: 1.20e-85
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86171918    116 CAPYRRLHLCVQNLEQIKPDQITSTHNLLVDVLLAAKYEGQSITQDYPKYQATYDDSPSKMCTMLARSFADIGDIVRGKD 195
Cdd:pfam05424    2 CAPPRRLHLCVKNLEKINSGNTTTTHDLLKAVILAAKYEGFSLWHKYKKKNTKYGDIPSEFCRQMAYSFADIGDIIRGKD 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86171918    196 LFLGTNEEKKpLEENLKEIFKKIYENLgiqeKNHYNDTPDYYKLREDWWIANRDQVWKAITCNAG-GYSYFRKTCGGDNE 274
Cdd:pfam05424   82 LYLGNNKKKK-LEENLKKIFKKIYEKL----TSKGKDDGNYYQLREDWWEANREDIWKAMTCALTyGAKYFRKTCGDGIS 156

                          170       180       190
                   ....*....|....*....|....*....|....*.
gi 86171918    275 KNSTlasnkcrckdekgeHDTDQVPTYFDYVPQYLR 310
Cdd:pfam05424  157 PSTA--------------GCNDDVPTYFDYVPQFLR 178
PTZ00176 PTZ00176
erythrocyte membrane protein 1 (PfEMP1); Provisional
 15-419 1.18e-70

erythrocyte membrane protein 1 (PfEMP1); Provisional


Pssm-ID: 140204 [Multi-domain]  Cd Length: 1317  Bit Score: 263.82  E-value: 1.18e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86171918    15 SVKDLFDRIGKEVHDQVEKEANqYKEALKGDLSSATFPTGRRH-----EKPQSESCKLNYIYDTNVTSG-GGKENPCYGR 88
Cdd:PTZ00176   14 SARNVLENIGNEIKDKRENESK-YTDKLKGSLWEARFSDGLSSsfgdvRSGYYDSCSLDHKFHTNINNGyPPARNPCDGR 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86171918    89 QGVRFSDTKGAKCYSYKIE--DNDSSIGFCAPYRRLHLCVQNLEQIKPDQITSTHNLLVDVLLAAKYEGQSITQDYPkyq 166
Cdd:PTZ00176   93 NQNRFDENGESYCNSDKIRgnENNSNAGACAPFRRQNMCDKNLEYLINKNTENTHDLLGNVLVTAKYEGESIVNNHP--- 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86171918   167 atyDDSPSKMCTMLARSFADIGDIVRGKDLFLGTNEEKkpLEENLKEIFKKIYENLGIQE-KNHYND--TPDYYKLREDW 243
Cdd:PTZ00176  170 ---DKDKSSVCTALARSFADIGDIVRGKDMFKRNKHDN--VENGLREVFKKIYEGLKNNGaREHYKEvkNGNYIKLREDW 244

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86171918   244 WIANRDQVWKAITCNAGGYSYFRKT-CGGDNEKNSTLASNKCrckdekgEHDTDqvPTYFDYVPQYLRWFEEWAEDFCRK 322
Cdd:PTZ00176  245 WTANRDQVWKAMTCVAPENAYFRKTeADGIGISSLILPYSKC-------GRDTD--PPVVDYIPQRLRWMSEWSEYFCNV 315

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86171918   323 KKIKVENVKKSCRgedkeskdrycsrngyDCEKTKRAIGKLRyGKQCISCLYGCNPYVDWIEKQKEQFDKQKKIYdkeiK 402
Cdd:PTZ00176  316 LNKEIDEMNNQCK----------------DCEMSRRCNNDTE-GEKCKKCKEQCQIFKELVSKWKNQFDKQSMKY----M 374

                         410
                  ....*....|....*..
gi 86171918   403 KYENGASSSSRKTRAAS 419
Cdd:PTZ00176  375 ELYNKASTNITKQNSSA 391
PTZ00176 PTZ00176
erythrocyte membrane protein 1 (PfEMP1); Provisional
 907-1601 4.74e-66

erythrocyte membrane protein 1 (PfEMP1); Provisional


Pssm-ID: 140204 [Multi-domain]  Cd Length: 1317  Bit Score: 249.18  E-value: 4.74e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86171918   907 EPCKGKdgNNERFKIGTEWKIG-EKVETSYKD----VFLPPRRQHMCTSNLENLdvdsVTENDKASHSLLGDVQLAAKTD 981
Cdd:PTZ00176   87 NPCDGR--NQNRFDENGESYCNsDKIRGNENNsnagACAPFRRQNMCDKNLEYL----INKNTENTHDLLGNVLVTAKYE 160

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86171918   982 AAEIIKRYKDqnniqltdpiqqKDQEAMCRAIRYSFADLGDIIRGRDMWnKDSGSTEMEKHLISIFEKINEKLPE---KE 1058
Cdd:PTZ00176  161 GESIVNNHPD------------KDKSSVCTALARSFADIGDIVRGKDMF-KRNKHDNVENGLREVFKKIYEGLKNngaRE 227

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86171918  1059 QKKYSNDGKYLDLRKDWWEANRYKVWKAMKC-ATKNS---KIPCSGI------------------PIEDYIPQRLRWMTE 1116
Cdd:PTZ00176  228 HYKEVKNGNYIKLREDWWTANRDQVWKAMTCvAPENAyfrKTEADGIgisslilpyskcgrdtdpPVVDYIPQRLRWMSE 307

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86171918  1117 WAEWFCKEQSQAYETLQDQCGKCTGPNKDNCTRDNNDCNTCTKACEEYEQKIKKWADQWKVISKKYEELYLQAKTAFART 1196
Cdd:PTZ00176  308 WSEYFCNVLNKEIDEMNNQCKDCEMSRRCNNDTEGEKCKKCKEQCQIFKELVSKWKNQFDKQSMKYMELYNKASTNITKQ 387

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86171918  1197 AFPDDDPDYQQvveffkelqkeinrsaSQRSKRSIDVTNTDPtltspyssaagYIHQEIGNVGCNVQ--------TQFCE 1268
Cdd:PTZ00176  388 NSSAPERGYRR----------------NHRRRGYDDDTNVQL-----------FLKKVIENNECKVEslgkyldkTSHCG 440

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86171918  1269 KKNGVIPTTgSGTNNKNyAFKNTPKDHDEACECESRPQVPPKKKEDEEDVCEKVKgllkgkdgettEINGCKP---KGNG 1345
Cdd:PTZ00176  441 NYNFNYDNT-PGSNRSN-AFEITPEKFKKACKCKIPNPLEKCPNEENKNVCTRFD-----------KVYSCTSlsfKNDL 507

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86171918  1346 NTWNCS---NQIDDSHkGACMPPRRQSLCIhNL--KESNETGTEQQLREAFINCAAIETFWLWYKYKKDKNvdaekkleq 1420
Cdd:PTZ00176  508 SEWNNSgvkNKENDNN-GVLVPPRRRNLCI-NLfsKKDYKMKDENDFKEDLLNAAFSQGKLLGKKYSNYSN--------- 576

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86171918  1421 geipsEFLRSMIYTFGDYRDLCLNTDIsakkdpikivKNNIQKVFNRNNGPHKEGDKEK----RKKFWETNKNDIWQGML 1496
Cdd:PTZ00176  577 -----EAYEAMKFSYADYSDIVKGTDM----------MNDLKKLNKELNTLLKETEKGDisvdRKTWWDDNKNVVWNAML 641

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86171918  1497 CALeKIANNKKTLTETYnyslvkfsgnnsTTLEDFAKTPQFLRWFTEWGDDFCqqqKEQLVtlQEACPNGICEQSEEEKK 1576
Cdd:PTZ00176  642 CGY-KTENENQQLNSSW------------CNVPDDDNIDQFLRWLTEWAQQYC---KEKLI--KAHIINTKCKDIVEGRK 703

                         730       740       750
                  ....*....|....*....|....*....|....*....
gi 86171918  1577 ----------KCKSACEKYQAFIE----KWKGYYDKQSK 1601
Cdd:PTZ00176  704 hksmvditdvECKRLFIDYEEWFRyrynQWKGLSEKYIK 742
PTZ00176 PTZ00176
erythrocyte membrane protein 1 (PfEMP1); Provisional
 2536-3067 1.24e-55

erythrocyte membrane protein 1 (PfEMP1); Provisional


Pssm-ID: 140204 [Multi-domain]  Cd Length: 1317  Bit Score: 215.67  E-value: 1.24e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86171918  2536 AMERSYADYGTIVKEDILWDYEDKKKIDPKIMN-FAKNHNISTTKTIVSSLDDDD----VK-RQKLWESIRIDVWKAMIC 2609
Cdd:PTZ00176  179 ALARSFADIGDIVRGKDMFKRNKHDNVENGLREvFKKIYEGLKNNGAREHYKEVKngnyIKlREDWWTANRDQVWKAMTC 258

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86171918  2610 -----GY---KDAIGGDMNSLPNDVDLC----TLPTTDDEYSFLRWFVEWGQNFCIRHEKELKQLNEEC-----ARGTCD 2672
Cdd:PTZ00176  259 vapenAYfrkTEADGIGISSLILPYSKCgrdtDPPVVDYIPQRLRWMSEWSEYFCNVLNKEIDEMNNQCkdcemSRRCNN 338

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86171918  2673 GTDEEKKKKCEKACKNYREFLNNFKKQYENQKKEY---------EIIK--SSYPK-----------YEKKDAFTFLKDKC 2730
Cdd:PTZ00176  339 DTEGEKCKKCKEQCQIFKELVSKWKNQFDKQSMKYmelynkastNITKqnSSAPErgyrrnhrrrgYDDDTNVQLFLKKV 418

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86171918  2731 NSNYSC---------------------FENKTEISVLKMFEHPPDDVKDECDCKTSKAHDDKVNDLDKCPNNINNNKNIc 2789
Cdd:PTZ00176  419 IENNECkveslgkyldktshcgnynfnYDNTPGSNRSNAFEITPEKFKKACKCKIPNPLEKCPNEENKNVCTRFDKVYS- 497

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86171918  2790 nkykkrriCGDLKYSNSLDHWFGTNT----------LIPPRRRHLCLrNIIIKKNYRKGDISKFKDDLFYAAASEAKFLF 2859
Cdd:PTZ00176  498 --------CTSLSFKNDLSEWNNSGVknkendnngvLVPPRRRNLCI-NLFSKKDYKMKDENDFKEDLLNAAFSQGKLLG 568

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86171918  2860 NNYEN-KNESLQAIKYTFADIGDIIKGNDMMDDMtyKKIKGKLEKVLDKT--GNNPETPEKWWEQNKKHVWEAMLCGYKL 2936
Cdd:PTZ00176  569 KKYSNySNEAYEAMKFSYADYSDIVKGTDMMNDL--KKLNKELNTLLKETekGDISVDRKTWWDDNKNVVWNAMLCGYKT 646

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86171918  2937 AGGEIKPND--CNIPTEESTHQFLRWLTEWGTQYCKEK--QQLKLNMQIPCMTHFDKYGIIENRIDVHpnCLQGLGKYEI 3012
Cdd:PTZ00176  647 ENENQQLNSswCNVPDDDNIDQFLRWLTEWAQQYCKEKliKAHIINTKCKDIVEGRKHKSMVDITDVE--CKRLFIDYEE 724

                         570       580       590       600       610
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 86171918  3013 WSNNRIPDWERLSSKFNEVKGTMNENV---KKLTAYEYLKQNCSKCICSFKDIEQTHK 3067
Cdd:PTZ00176  725 WFRYRYNQWKGLSEKYIKIKKSKNSGVnipSEECAASYVTKHCNGCICNLRDMEDIHK 782
Duffy_binding pfam05424
Duffy binding domain; This domain is found in Plasmodium Duffy binding proteins. Plasmodium ...
 1361-1539 5.03e-47

Duffy binding domain; This domain is found in Plasmodium Duffy binding proteins. Plasmodium vivax and Plasmodium knowlesi merozoites invade human erythrocytes that express Duffy blood group surface determinants. The Duffy receptor family is localized in micronemes, an organelle found in all organizms of the phylum Apicomplexa. This family is closely associated on PfEMP1 proteins with PFEMP, pfam03011.


Pssm-ID: 428465 [Multi-domain]  Cd Length: 178  Bit Score: 167.84  E-value: 5.03e-47
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86171918   1361 ACMPPRRQSLCIHNLK--ESNETGTEQQLREAFINCAAIETFWLWYKYKKDKNVDaekkleqGEIPSEFLRSMIYTFGDY 1438
Cdd:pfam05424    1 ACAPPRRLHLCVKNLEkiNSGNTTTTHDLLKAVILAAKYEGFSLWHKYKKKNTKY-------GDIPSEFCRQMAYSFADI 73

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86171918   1439 RDLCLNTDISAKKDPIKIVKNNIQKVFNRNNGPHKEGDK------EKRKKFWETNKNDIWQGMLCALEKiaNNKKTLTET 1512
Cdd:pfam05424   74 GDIIRGKDLYLGNNKKKKLEENLKKIFKKIYEKLTSKGKddgnyyQLREDWWEANREDIWKAMTCALTY--GAKYFRKTC 151

                          170       180
                   ....*....|....*....|....*..
gi 86171918   1513 YNYSLVKFSGNNSTTLEDFAKTPQFLR 1539
Cdd:pfam05424  152 GDGISPSTAGCNDDVPTYFDYVPQFLR 178
Duffy_binding pfam05424
Duffy binding domain; This domain is found in Plasmodium Duffy binding proteins. Plasmodium ...
 941-1112 2.68e-46

Duffy binding domain; This domain is found in Plasmodium Duffy binding proteins. Plasmodium vivax and Plasmodium knowlesi merozoites invade human erythrocytes that express Duffy blood group surface determinants. The Duffy receptor family is localized in micronemes, an organelle found in all organizms of the phylum Apicomplexa. This family is closely associated on PfEMP1 proteins with PFEMP, pfam03011.


Pssm-ID: 428465 [Multi-domain]  Cd Length: 178  Bit Score: 165.91  E-value: 2.68e-46
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86171918    941 PPRRQHMCTSNLENLDvdsvTENDKASHSLLGDVQLAAKTDAAEIIKRYKDQNNIQLTDPIQqkdqeaMCRAIRYSFADL 1020
Cdd:pfam05424    4 PPRRLHLCVKNLEKIN----SGNTTTTHDLLKAVILAAKYEGFSLWHKYKKKNTKYGDIPSE------FCRQMAYSFADI 73

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86171918   1021 GDIIRGRDMWNKDSGSTEMEKHLISIFEKINEKLPEKEQKkysnDGKYLDLRKDWWEANRYKVWKAMKCA-----TKNSK 1095
Cdd:pfam05424   74 GDIIRGKDLYLGNNKKKKLEENLKKIFKKIYEKLTSKGKD----DGNYYQLREDWWEANREDIWKAMTCAltygaKYFRK 149

                          170       180
                   ....*....|....*....|....*....
gi 86171918   1096 IPCSGIPIE------------DYIPQRLR 1112
Cdd:pfam05424  150 TCGDGISPStagcnddvptyfDYVPQFLR 178
Duffy_binding pfam05424
Duffy binding domain; This domain is found in Plasmodium Duffy binding proteins. Plasmodium ...
 1762-1940 2.01e-35

Duffy binding domain; This domain is found in Plasmodium Duffy binding proteins. Plasmodium vivax and Plasmodium knowlesi merozoites invade human erythrocytes that express Duffy blood group surface determinants. The Duffy receptor family is localized in micronemes, an organelle found in all organizms of the phylum Apicomplexa. This family is closely associated on PfEMP1 proteins with PFEMP, pfam03011.


Pssm-ID: 428465 [Multi-domain]  Cd Length: 178  Bit Score: 134.71  E-value: 2.01e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86171918   1762 CIPPRRQQMYIQPLQSLSGNE--SQVELRRIFIEMAAIETFFQWHKFKKekvreikekdeidgkislfgqddtsieenlq 1839
Cdd:pfam05424    2 CAPPRRLHLCVKNLEKINSGNttTTHDLLKAVILAAKYEGFSLWHKYKK------------------------------- 50

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86171918   1840 KQLKNGTIPDDFKRQMFYTFGDYKDILFGK--YIG-IDMGTVKTNIGRVFNNGGNK----------SDEEREKWWKNHGP 1906
Cdd:pfam05424   51 KNTKYGDIPSEFCRQMAYSFADIGDIIRGKdlYLGnNKKKKLEENLKKIFKKIYEKltskgkddgnYYQLREDWWEANRE 130

                          170       180       190
                   ....*....|....*....|....*....|....
gi 86171918   1907 SIWNGMLCGLSYDTKTKHNIQGVYTQLTDPSKNN 1940
Cdd:pfam05424  131 DIWKAMTCALTYGAKYFRKTCGDGISPSTAGCND 164
PFEMP pfam03011
PFEMP1 DBL domain; PfEMP1 (Plasmodium falciparum erythrocyte membrane protein) has been ...
 652-811 1.05e-30

PFEMP1 DBL domain; PfEMP1 (Plasmodium falciparum erythrocyte membrane protein) has been identified as the rosetting ligand of the malaria parasite P. falciparum. Rosetting is the adhesion of infected erythrocytes with uninfected erythrocytes in the vasculature of the infected organ, and is associated with severe malaria. PfEMP1 interacts with Complement Receptor One on uninfected erythrocytes to form rosettes. The extreme variation within these proteins and the grouping of var genes implies that var gene recombination preferentially occurs within var gene groups. These groups reflect a functional diversification that has evolved to cope with the varying conditions of transmission and host immune response met by the parasite. A recombination hotspot was uncovered between Duffy-binding-like (DBL) subdomains. Solution of the crystal structure of the N-terminal and first DBL region of PfEMP1 from the VarO variant of the PfEMP1 protein is found to be directly implicated in rosetting as the heparin-binding site.


Pssm-ID: 281064  Cd Length: 154  Bit Score: 120.29  E-value: 1.05e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86171918    652 FFYYWVAHMLKDSIHWKKKLQRCLEKKNGNTCKKnNCKDNCGCFEKWVAQKKEqEWDPIKQQFRKQDFGKqELILGQIRY 731
Cdd:pfam03011    1 LFKRWVEYFLEDSIKWRKKLKSCINNGKGKCCKK-ECKNDCECFKKWVEKKKE-EWKKIKEHFLKQYKLK-GLTGKTLDE 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86171918    732 DYVLDELLKKDELLTSIKEGYGDANEIKHIKALLEDEENEETQEEetaGADNQKKNTIDWLIQHEEDDAELCLEIHEDEE 811
Cdd:pfam03011   78 YLDLKSFLETFLFYIDIKEAYGDVKELKKLEEILDEEGCSAGAES---AKNNKNEDAIDKLLDKEEKKANNCKEKHKEND 154
PTZ00176 PTZ00176
erythrocyte membrane protein 1 (PfEMP1); Provisional
 1337-1997 1.33e-28

erythrocyte membrane protein 1 (PfEMP1); Provisional


Pssm-ID: 140204 [Multi-domain]  Cd Length: 1317  Bit Score: 127.07  E-value: 1.33e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86171918  1337 NGCKPKGNGNTWNCsnqiddshkGACMPPRRQSLCIHNLK---ESNETGTEQQLREAFINCaaietfwlwyKYKKDKNVD 1413
Cdd:PTZ00176  106 NSDKIRGNENNSNA---------GACAPFRRQNMCDKNLEyliNKNTENTHDLLGNVLVTA----------KYEGESIVN 166

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86171918  1414 AEKKLEQGEIPSEFLRSmiytFGDYRDLCLNTDIsAKKDPIKIVKNNIQKVFNR-NNGPHKEGDKEK------------R 1480
Cdd:PTZ00176  167 NHPDKDKSSVCTALARS----FADIGDIVRGKDM-FKRNKHDNVENGLREVFKKiYEGLKNNGAREHykevkngnyiklR 241

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86171918  1481 KKFWETNKNDIWQGMLCALEKIANNKKTLTETYNYSLV-----KFSGNNSTTLEDFakTPQFLRWFTEWGDDFCQQQKEQ 1555
Cdd:PTZ00176  242 EDWWTANRDQVWKAMTCVAPENAYFRKTEADGIGISSLilpysKCGRDTDPPVVDY--IPQRLRWMSEWSEYFCNVLNKE 319

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86171918  1556 LVTLQEACPNgiCEQSE--------EEKKKCKSACEKYQAFIEKWKGYYDKQSKKY---FYDISTGMYKDNSSA------ 1618
Cdd:PTZ00176  320 IDEMNNQCKD--CEMSRrcnndtegEKCKKCKEQCQIFKELVSKWKNQFDKQSMKYmelYNKASTNITKQNSSApergyr 397

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86171918  1619 --------KDDVTVSSYayeylnksLKKLCPDGSCSC------MEQRSQQHNEDsSDALETHNSIMPQSLDKEPKEVKGR 1684
Cdd:PTZ00176  398 rnhrrrgyDDDTNVQLF--------LKKVIENNECKVeslgkyLDKTSHCGNYN-FNYDNTPGSNRSNAFEITPEKFKKA 468

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86171918  1685 CKC--PDPPKPCDIVkdlfENKDD-NKFTEACSTKYKNGKEKYTQWkciNDSSNTTRssppapvasstlstspEAGASAT 1761
Cdd:PTZ00176  469 CKCkiPNPLEKCPNE----ENKNVcTRFDKVYSCTSLSFKNDLSEW---NNSGVKNK----------------ENDNNGV 525

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86171918  1762 CIPPRRQQMYIqplqslsgnesqvelrrifiemaaietffqwHKFKKekvREIKEKDEIDGKISLFGQdDTSIEENLQKQ 1841
Cdd:PTZ00176  526 LVPPRRRNLCI-------------------------------NLFSK---KDYKMKDENDFKEDLLNA-AFSQGKLLGKK 570

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86171918  1842 LKNGTipDDFKRQMFYTFGDYKDILFGKYIGIDMGTVKTNIGRVFNNgGNKSD--EEREKWWKNHGPSIWNGMLCGlsYD 1919
Cdd:PTZ00176  571 YSNYS--NEAYEAMKFSYADYSDIVKGTDMMNDLKKLNKELNTLLKE-TEKGDisVDRKTWWDDNKNVVWNAMLCG--YK 645

                         650       660       670       680       690       700       710
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 86171918  1920 TKTKhNIQGVYTQLTDPSKNNmyekvtfpsktgpsvntkLEQFarrptyFRWLEEWGEEFCKKRTDKLKKLEKECRGV 1997
Cdd:PTZ00176  646 TENE-NQQLNSSWCNVPDDDN------------------IDQF------LRWLTEWAQQYCKEKLIKAHIINTKCKDI 698
Duffy_binding pfam05424
Duffy binding domain; This domain is found in Plasmodium Duffy binding proteins. Plasmodium ...
 2817-2933 6.15e-26

Duffy binding domain; This domain is found in Plasmodium Duffy binding proteins. Plasmodium vivax and Plasmodium knowlesi merozoites invade human erythrocytes that express Duffy blood group surface determinants. The Duffy receptor family is localized in micronemes, an organelle found in all organizms of the phylum Apicomplexa. This family is closely associated on PfEMP1 proteins with PFEMP, pfam03011.


Pssm-ID: 428465 [Multi-domain]  Cd Length: 178  Bit Score: 107.36  E-value: 6.15e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86171918   2817 IPPRRRHLCLRNIIIKKNYRKGDISKFKDDLFYAAASEAKFLFNNYENKNES--------LQAIKYTFADIGDIIKGNDM 2888
Cdd:pfam05424    3 APPRRLHLCVKNLEKINSGNTTTTHDLLKAVILAAKYEGFSLWHKYKKKNTKygdipsefCRQMAYSFADIGDIIRGKDL 82

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 86171918   2889 -MDDMTYKKIKGKLEKVLDKTGNNP-----------ETPEKWWEQNKKHVWEAMLCG 2933
Cdd:pfam05424   83 yLGNNKKKKLEENLKKIFKKIYEKLtskgkddgnyyQLREDWWEANREDIWKAMTCA 139
PFEMP pfam03011
PFEMP1 DBL domain; PfEMP1 (Plasmodium falciparum erythrocyte membrane protein) has been ...
 2223-2367 1.70e-21

PFEMP1 DBL domain; PfEMP1 (Plasmodium falciparum erythrocyte membrane protein) has been identified as the rosetting ligand of the malaria parasite P. falciparum. Rosetting is the adhesion of infected erythrocytes with uninfected erythrocytes in the vasculature of the infected organ, and is associated with severe malaria. PfEMP1 interacts with Complement Receptor One on uninfected erythrocytes to form rosettes. The extreme variation within these proteins and the grouping of var genes implies that var gene recombination preferentially occurs within var gene groups. These groups reflect a functional diversification that has evolved to cope with the varying conditions of transmission and host immune response met by the parasite. A recombination hotspot was uncovered between Duffy-binding-like (DBL) subdomains. Solution of the crystal structure of the N-terminal and first DBL region of PfEMP1 from the VarO variant of the PfEMP1 protein is found to be directly implicated in rosetting as the heparin-binding site.


Pssm-ID: 281064  Cd Length: 154  Bit Score: 93.72  E-value: 1.70e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86171918   2223 LFHRWITDFIQYYNKSKEKIKPCTNDVN--SCKQGCKGNCDCVDKWLKNKSTEWEIIKKYYKENFGNTNEHIAYA----- 2295
Cdd:pfam03011    1 LFKRWVEYFLEDSIKWRKKLKSCINNGKgkCCKKECKNDCECFKKWVEKKKEEWKKIKEHFLKQYKLKGLTGKTLdeyld 80

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 86171918   2296 IKIFLQEGLFDSDYKRAQEVIDQ-NEWEQLWGCTGDNLKDVkdqKAENCNKGDFITNLISKLQDKITSCQNKH 2367
Cdd:pfam03011   81 LKSFLETFLFYIDIKEAYGDVKElKKLEEILDEEGCSAGAE---SAKNNKNEDAIDKLLDKEEKKANNCKEKH 150
Duffy_binding pfam05424
Duffy binding domain; This domain is found in Plasmodium Duffy binding proteins. Plasmodium ...
 3146-3286 3.33e-20

Duffy binding domain; This domain is found in Plasmodium Duffy binding proteins. Plasmodium vivax and Plasmodium knowlesi merozoites invade human erythrocytes that express Duffy blood group surface determinants. The Duffy receptor family is localized in micronemes, an organelle found in all organizms of the phylum Apicomplexa. This family is closely associated on PfEMP1 proteins with PFEMP, pfam03011.


Pssm-ID: 428465 [Multi-domain]  Cd Length: 178  Bit Score: 90.80  E-value: 3.33e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86171918   3146 VPPRRRHLCLR----IDVNKflrlRNDINNLKTFICKSAFAEAKRLKKVYKDDNSKLHQ-------AMKYSFSDIGSVVK 3214
Cdd:pfam05424    3 APPRRLHLCVKnlekINSGN----TTTTHDLLKAVILAAKYEGFSLWHKYKKKNTKYGDipsefcrQMAYSFADIGDIIR 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86171918   3215 GNDMM-----ESPTSDNIAKIFR--GMKYTEIN---------RETWWDLNKYHVWESMLCG---------YREAGGDTKK 3269
Cdd:pfam05424   79 GKDLYlgnnkKKKLEENLKKIFKkiYEKLTSKGkddgnyyqlREDWWEANREDIWKAMTCAltygakyfrKTCGDGISPS 158

                          170       180
                   ....*....|....*....|
gi 86171918   3270 SENCRF---PDIERVPQFLR 3286
Cdd:pfam05424  159 TAGCNDdvpTYFDYVPQFLR 178
PTZ00176 PTZ00176
erythrocyte membrane protein 1 (PfEMP1); Provisional
 3117-3362 4.21e-19

erythrocyte membrane protein 1 (PfEMP1); Provisional


Pssm-ID: 140204 [Multi-domain]  Cd Length: 1317  Bit Score: 95.87  E-value: 4.21e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86171918  3117 PCRG-----VSHDDDNDWNSSFVKDN-KTTNLGVLVPPRRRHLClriDVN-KFLRLRN--DINNLKTFICKSAFAEAKRL 3187
Cdd:PTZ00176   88 PCDGrnqnrFDENGESYCNSDKIRGNeNNSNAGACAPFRRQNMC---DKNlEYLINKNteNTHDLLGNVLVTAKYEGESI 164

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86171918  3188 KKVYKD-DNSKLHQAMKYSFSDIGSVVKGNDMMESPTSDNI--------AKIFRGMK-------YTEIN-------RETW 3244
Cdd:PTZ00176  165 VNNHPDkDKSSVCTALARSFADIGDIVRGKDMFKRNKHDNVenglrevfKKIYEGLKnngarehYKEVKngnyiklREDW 244

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86171918  3245 WDLNKYHVWESMLC-----GY---REAGG---------DTKKSENCRFPDIERVPQFLRWFQEWTEIFCIKRKTLYDKMV 3307
Cdd:PTZ00176  245 WTANRDQVWKAMTCvapenAYfrkTEADGigisslilpYSKCGRDTDPPVVDYIPQRLRWMSEWSEYFCNVLNKEIDEMN 324

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 86171918  3308 TECQKAE----CDTSNGTVKETKCTKACEEYKSYVLSKKKEYYIQKDKYDNQFKKVLNN 3362
Cdd:PTZ00176  325 NQCKDCEmsrrCNNDTEGEKCKKCKEQCQIFKELVSKWKNQFDKQSMKYMELYNKASTN 383
Duffy_binding pfam05424
Duffy binding domain; This domain is found in Plasmodium Duffy binding proteins. Plasmodium ...
 2464-2636 2.29e-17

Duffy binding domain; This domain is found in Plasmodium Duffy binding proteins. Plasmodium vivax and Plasmodium knowlesi merozoites invade human erythrocytes that express Duffy blood group surface determinants. The Duffy receptor family is localized in micronemes, an organelle found in all organizms of the phylum Apicomplexa. This family is closely associated on PfEMP1 proteins with PFEMP, pfam03011.


Pssm-ID: 428465 [Multi-domain]  Cd Length: 178  Bit Score: 82.71  E-value: 2.29e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86171918   2464 VYISPRAHQLYLEPLKDLKENNT-DKNELIKAFTKCAYNEGKCLYEYYSKNKATLGKngsalSNDEVKTytleAMERSYA 2542
Cdd:pfam05424    1 ACAPPRRLHLCVKNLEKINSGNTtTTHDLLKAVILAAKYEGFSLWHKYKKKNTKYGD-----IPSEFCR----QMAYSFA 71

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86171918   2543 DYGTIVK-EDILWDYEDKKKIDPKIMN-FAKNHNisTTKTIVSSLDDDDVKRQKLWESIRIDVWKAMICG------YKDA 2614
Cdd:pfam05424   72 DIGDIIRgKDLYLGNNKKKKLEENLKKiFKKIYE--KLTSKGKDDGNYYQLREDWWEANREDIWKAMTCAltygakYFRK 149

                          170       180
                   ....*....|....*....|..
gi 86171918   2615 IGGDMNSLPNDVDLCTLPTTDD 2636
Cdd:pfam05424  150 TCGDGISPSTAGCNDDVPTYFD 171
PTZ00176 PTZ00176
erythrocyte membrane protein 1 (PfEMP1); Provisional
 105-335 3.90e-13

erythrocyte membrane protein 1 (PfEMP1); Provisional


Pssm-ID: 140204 [Multi-domain]  Cd Length: 1317  Bit Score: 76.23  E-value: 3.90e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86171918   105 KIEDNDSSiGFCAPYRRLHLCVqNLEQIKPDQITSTHNLLVDVLLAAKYEGQSITQDYPKYQatyddspSKMCTMLARSF 184
Cdd:PTZ00176  516 KNKENDNN-GVLVPPRRRNLCI-NLFSKKDYKMKDENDFKEDLLNAAFSQGKLLGKKYSNYS-------NEAYEAMKFSY 586

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86171918   185 ADIGDIVRGKDLFLGTNEEKKPLEENLKEIFKKiyenlgiqeknhyndtpDYYKLREDWWIANRDQVWKAITCnagGYsy 264
Cdd:PTZ00176  587 ADYSDIVKGTDMMNDLKKLNKELNTLLKETEKG-----------------DISVDRKTWWDDNKNVVWNAMLC---GY-- 644

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 86171918   265 frKTcggDNEkNSTLASNKCRCKDEkgehdtdqvptyfDYVPQYLRWFEEWAEDFCRKKKIKVENVKKSCR 335
Cdd:PTZ00176  645 --KT---ENE-NQQLNSSWCNVPDD-------------DNIDQFLRWLTEWAQQYCKEKLIKAHIINTKCK 696
NTS pfam15447
N-terminal segments of PfEMP1; This family, the N-terminal segment, is the most variable part ...
 15-50 1.36e-12

N-terminal segments of PfEMP1; This family, the N-terminal segment, is the most variable part of the variant surface antigen family of Plasmodium falciparum, the erythrocyte membrane protein-1 (PfEMP1) proteins. PfEMP1 is an important target for protective immunity and is implicated in the pathology of malaria through its ability to adhere to host endothelial receptors. A structural and functional study of the N-terminal domain of PfEMP1 from the VarO variant comprising the N-terminal segment (NTS) and the first DBL domain (DBL1alpha1), shows this region is directly implicated in rosetting. NTS, previously thought to be a structurally independent component of PfEMP1, forms an integral part of the DBL1alpha domain that is found to be the important heparin-binding site. This family is closely associated with PFEMP, pfam03011, and Duffy_binding, pfam05424.


Pssm-ID: 406013 [Multi-domain]  Cd Length: 36  Bit Score: 64.34  E-value: 1.36e-12
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 86171918     15 SVKDLFDRIGKEVHDQVEKEANQYKEALKGDLSSAT 50
Cdd:pfam15447    1 SAKHLLDRIGKDVHDKVKKEAKRYKSELKGDLSKAK 36
PTZ00176 PTZ00176
erythrocyte membrane protein 1 (PfEMP1); Provisional
 2464-2666 2.76e-11

erythrocyte membrane protein 1 (PfEMP1); Provisional


Pssm-ID: 140204 [Multi-domain]  Cd Length: 1317  Bit Score: 70.45  E-value: 2.76e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86171918  2464 VYISPRAHQLYLEPLKDLKENNTDKNELIKAFTKCAYNEGKclyeyysknkaTLGKNGSALSNDevktyTLEAMERSYAD 2543
Cdd:PTZ00176  525 VLVPPRRRNLCINLFSKKDYKMKDENDFKEDLLNAAFSQGK-----------LLGKKYSNYSNE-----AYEAMKFSYAD 588

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86171918  2544 YGTIVK-EDILwdyEDKKKIDPKIMNFAKnhniSTTKTIVSslddddVKRQKLWESIRIDVWKAMICGYK-DAIGGDMNS 2621
Cdd:PTZ00176  589 YSDIVKgTDMM---NDLKKLNKELNTLLK----ETEKGDIS------VDRKTWWDDNKNVVWNAMLCGYKtENENQQLNS 655

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 86171918  2622 lpndvDLCTLPTTDDEYSFLRWFVEWGQNFCirHEKELKQ--LNEEC 2666
Cdd:PTZ00176  656 -----SWCNVPDDDNIDQFLRWLTEWAQQYC--KEKLIKAhiINTKC 695
PTZ00176 PTZ00176
erythrocyte membrane protein 1 (PfEMP1); Provisional
 1897-2072 1.03e-07

erythrocyte membrane protein 1 (PfEMP1); Provisional


Pssm-ID: 140204 [Multi-domain]  Cd Length: 1317  Bit Score: 58.51  E-value: 1.03e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86171918  1897 REKWWKNHGPSIWNGMLCGL---SYDTKTKHNIQGVYTQLTDPSKNNmyekvtfpSKTGPSVNTKLeqfarrPTYFRWLE 1973
Cdd:PTZ00176  241 REDWWTANRDQVWKAMTCVApenAYFRKTEADGIGISSLILPYSKCG--------RDTDPPVVDYI------PQRLRWMS 306

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86171918  1974 EWGEEFCKKRTDKLKKLEKECRGVNYSgynKYCSgdgyhcDDEKGTynsinanlNCRDCMKECRNYKTWIVKKKNEYDKQ 2053
Cdd:PTZ00176  307 EWSEYFCNVLNKEIDEMNNQCKDCEMS---RRCN------NDTEGE--------KCKKCKEQCQIFKELVSKWKNQFDKQ 369

                         170
                  ....*....|....*....
gi 86171918  2054 KSKYVNEHENVISFLNKQS 2072
Cdd:PTZ00176  370 SMKYMELYNKASTNITKQN 388
LbR_Ice_bind cd12796
Ice-binding protein, left-handed beta-roll; The ice-binding protein of the grass Lolium ...
 3634-3753 2.57e-04

Ice-binding protein, left-handed beta-roll; The ice-binding protein of the grass Lolium perenne (LpIBP) discourages the recrystallization of ice. Ice-binding proteins produced by organisms to prevent the growing of ice are termed to anti-freeze proteins. LpIBP consists of an unusual left-handed beta roll. Ice-binding is mediated by a flat beta-sheet on one side of the helix.


Pssm-ID: 240609 [Multi-domain]  Cd Length: 114  Bit Score: 43.16  E-value: 2.57e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86171918 3634 VEEKPFIMSIHDRNLYTGEEYNYDMSTN---SGNNDLYNGKNNLYSGQNNVYSGidptsdNRGPYSDKNDRISDNHHPYS 3710
Cdd:cd12796   13 SGSENNVIAGGQNLVVSGSNNLVSGGNHnvlSGNNNTVSGNNHVVTGSNNVVTG------NGNTVSGSNNVVSGSNNTVS 86

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 86171918 3711 GidlINDTLSGNAHIdiydellkrkeneLFGTNHVKHTSTHSV 3753
Cdd:cd12796   87 G---GNNTVSGSNNT-------------VSGSNHIVSGNNKVV 113
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH